DEPARTMENT OF PHARMACY SERVICES
THQ HOSPITAL CHAK JHUMRA
FAISALABAD, PAKISTAN
email: mms.thq.ckj@gmail.com
Reconstitution And Administration protocol of ACYCLOVIR
Reconstitution and Stability
Do not use if seal is broken or if there is incomplete reconstitution of contents upon addition of sterile
diluent within three minutes.
Reconstitute vial content with the required quantity of sterile diluent.
The calculated dose should then be removed and added to any appropriate intravenous solution (5%
Dextrose, 0.9% Sodium Chloride, 5% Dextrose/0.9% Sodium Chloride, 5% Dextrose/0.2% Sodium
Chloride, Ringers and Lactated Ringers Injection) at a volume selected for administration during each 1hour infusion.
Infusion concentrations of approximately 7 mg/mL or lower are recommended. Higher concentrations
(e.g., 10 mg/mL) may produce phlebitis or inflammation at the injection site upon inadvertent
extravasation.
Storage: The reconstituted solution should be used within 12 hours. Once diluted for administration,
each dose should be used within 24 hours.
Refrigeration of reconstituted solutions may result in formation of a precipitate which will re dissolve at
room temperature.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to
administration, whenever solution and container permit.
Caution : RAPID OR BOLUS INTRAVENOUS INJECTION MUST BE AVOIDED
INTRAMUSCULAR OR SUBCUTANEOUS INJECTION MUST BE AVOIDED
THE CONTENTS OF THE VIAL SHOULD BE DISSOLVED IN STERILE WATER FOR INJECTION OR 0.9%
SODIUM CHLORIDE AS FOLLOWS.
SHAKE THE VIAL WELL TO ASSURE COMPLETE DISSOLUTION BEFORE MEASURING AND TRANSFERRING
EACH INDIVIDUAL DOSE.
DO NOT USE BACTERIOSTATIC WATER FOR INJECTION CONTAINING BENZYL ALCOHOL OR PARABENS.
ACYCLOVIR SODIUM STERILE POWDER FOR SOLUTION FOR INJECTION MUST BE DILUTED PRIOR TO
ADMINISTRATION.
WHEN ADMINISTERING ACYCLOVIR SODIUM FOR SOLUTION FOR INJECTION, (OR ANY POTENT
MEDICATION) BY CONTINUOUS INTRAVENOUS INFUSION, IT IS ADVISABLE TO USE A PRECISION VOLUME
CONTROL IV SET.
PREPARED BY:
RECOMMENDED BY:
CLINICAL PHARMACIST & PHARMACOVIGILANT OFFICER
INCHARGE INDOOR MEDICINE STORE