Global Reference List of Natural Complex
Substances/Natural Flavouring Complexes
22/01/2021
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1/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Abelmoschus moschatus Medik.
Ambrette
English Name
Abies alba Mill.
Abies balsamea (L.) Mill.
Abies sibirica Ledeb.
Abies spp.
Acacia catechu (L.f.) Willd.
Acacia dealbata Link
Silver fir
balsam fir
Siberian pitch fir
Pine
Catechu fir
Silver wattle
Acacia decurrens (W.) Willd.
Acacia farnesiana (L.) Willd.
Acacia senegal (L.) Willd.
Mimosa
Cassie
Arabic gum tree
Acer negundo L.
Acer saccharum L.
Acer spicatum Lam.
Achillea erba-rotta subsp. moschata (Wulfen)
I.Richardson
Achillea millefolium L.
Maple tree
Black sugar maple
Mountain maple
Musk milfoil
Achillea moschata Jacq.
Musk Yarrow
Acmella oleracea (L.) R.K.Jansen
Actinida chinensis Planch.
Adiantum capillus-veneris L.
Jambu
Kiwi
Venus hair
3783 (oleoresin)
Aframomum melegueta (Rosc.) K. Schumann
Agaricus bisporus
Agathis australis (D.Don) Lindl.
Agathosma betulina (P.J.Bergius) Pillans
Agathosma betulina x crenulata
Agathosma crenulata (L.) Pillans
Agave americana L.
Agropyron repens ( L.) Beauv.
Ajuga chamaepitys (L.) Schreb.
Allium ascalonicum L.
Allium cepa L.
Allium porrum L.
Allium sativum L.
Allium schoenoprasum L
Aloe ferox Mill.
Aloe vera L.
Grains of paradise
Mushroom
Kauri
Round leaf buchu
Round leaf buchu
Oval leaf buchu
American aloe
Dog grass
Yellow bugle
Shallot
Onion
Leek
Garlic
Chive
Cape aloe
Aloe
2529 (grains of paradise)
4487 (oil, distilled)
Milfoil
FEMA
2050 (seed absolute); 2051 (seed oil); 2052
(tincture)
2905 (needle oil)
2114 (oil); 2115 (oleoresin)
2905 (needle oil)
2905 (needle oil)
2264 (extract); 2265 (powder)
US FDA
CFR.21 §182.10; CFR.21 §182.20
2755 (absolute)
2260 (absolute)
2001 (acacia gum)
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §184.1330; CFR.21
§184.1333
2757 (extract solid)
3117 (herb extract)
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §172.510
COE2; COE4
COE3
COE5
COE6
COE522; COE572;
COE2001; COE6000;
COE7
COE8
COE9
COE10
COE11
CFR.21 §172.510
COE2002
COE562; COE1200;
COE2003;
CFR.21 §172.510 (In beverages only; COE12
Finished beverage thujone free)
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §182.10
2169 (leaves oil); 4923 (leaves extract)
2169 (leaves oil)
2169 (leaves oil); 4923 (leaves extract)
CFR.21 §172.510
2403 (extract)
CFR.21 §182.20
2817 (oil)
CFR.21 §182.20
2503 (oil)
CFR.21 §184.1317
CFR.21 §182.10
CFR.21 §172.510
CFR.21 §172.510
2047 (concentrated juice from leaves)
2047 (extract)
COE
COE1
CFR.21 §172.510
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COE12A
COE2004
COE14
COE15
COE543; COE2005
COE2006
COE 85; COE 85a
COE85c
COE 85b
COE17
COE19
COE20
COE23
COE24
COE25
COE26
COE27
COE28A
COE28
2/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Alpinia galanga (L.) Willd.
English Name
Greater galanga
FEMA
2498 (root); 2499 (root extracts); 2500 (root oil)
Alpinia officinarum Hance
Lesser galanga
2498 (root); 2499 (root extracts); 2500 (root oil)
US FDA
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §182.10; CFR.21 §182.20
Alpinia spp.
Galangal root
2498 (root); 2499 (root extract); 2500 (root oil)
CFR.21 §172.510
Althaea officinalis L.
Althaea rosea (L.) Cav.
Amygdalus communis L.
Amyris balsamifera L.
Anacardium occidentale L.
Anacyclus officinarum Hayne
Anacyclus pyrethrum Lag.
Ananas comosus (L.) Merril
Andrographis paniculata Nees
Anethum graveolens L.
Marsh mallow
Rose mallow
Bitter almond
West Indian sandalwood
Cashew
Pellitory of Germany
Pellitory
Pineapple
Indian chiretta
Dill
2048 (althea root)
CFR.21 §172.510
Anethum sowa Roxb. ex Fleming
Angelica archangelica L.
Indian Dill
Angelica
2384 (seed)
2087 (root extract); 2088 (root oil); 2089 (seed
extract); 2090 (seed oil); 2091 (stem oil)
CFR.21 §182.10; CFR.21 §182.20
Angelica sylvestris L.
Aniba rosaeodora var. amazonica Ducke
Annona cherimola Mill.
Wild angelica
Bois de rose
Custard apple
2156 (oil)
CFR.21 §182.20
Annona muricata L.
Annona reticulata L.
Annona squamosa L.
Anogeissus latifolia (Roxb. ex DC.) Wall. ex
Guillem. & Perr.
Anthemis nobilis L.
Corrosol
Bull's heart
Sugar apple
Ghatti gum
Anthoxanthum odoratum L.
Anthriscus cerefolium (L.) Hoffm.
Anthyllis vulneraria L.
Apis Mellifera L
Pig grass
Chervil
Woundwort
Beeswax
Apium graveolens L.
Celery
Arachis hypogaea L.
Arbutus unedo L.
Arctium lappa L.
Peanut
Strawberry tree
Great burdock
Camomile
2046 (oil)
2382 (dill); 2383 (oil)
COE
COE29
COE30
COE31
COE32
CFR.21 §182.20
COE366
CFR.21 §172.510
COE33
COE34
COE35
COE2007
COE36
COE37
CFR.21 §172.510; CFR.21 §184.1282 COE42
COE56
COE43
COE44
COE46A; COE570;
COE2008; COE4600;
COE45
COE47
COE46
2519 (ghatti gum)
2272 (english flower, oil); 2274 (roman flower
extract); 2275 (roman flower oil)
CFR.21 §182.10; CFR.21 §182.20
2279 (chervil)
CFR.21 §182.10; CFR.21 §182.20
2126 (beeswax absolute)
2268 (seed); 2269 (seed extract); 2270 (seed
extract solid); 2271 (seed oil);
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §182.40
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COE48
COE49
COE50
COE51
COE553; COE1001; COEI
(honey)
COE52; COE2009
COE54
COE55
COE57
3/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Aristolochia serpentaria L.
English Name
Serpentary
Armoracia lapathifolia Gilib.
Arnica montana L.
Horseradish
Arnica
Artemisia abrotanum L.
Artemisia absinthium L.
Southerwood
Wormwood herb
Artemisia dracunculus L.
Artemisia glacialis L.
Artemisia herba-alba Asso.
Artemisia mutellina Vill.
Artemisia pallens Wall.
Artemisia pontica L.
Artemisia spicata Wulf.
Artemisia vallesiana Lam.
Artemisia vulgaris L.
Artocarpus incisa J. H. & G. Forster
Asarum canadense L.
Asarum europaeum L.
Ascophyllum nodosum
Asparagus officinalis L.
Tarragon
Glacier wormwood
White wormwood
Alpine wormwood,
Davana
Pontique wormwood
Geneppi
Mountain wormwood
Common mugwort
Bread fruit tree
Canadian snakeroot
Hazelwort
Knotted wrack
Garden asparagus
Asperula odorata L.
Woodruff
Aspidosperma quebracho-blanco Schltdl.
Astragalus gummifer Labill.
Averrhoa bilimbi L.
Averrhoa carambola L.
Baccharis genistelloides (Lam.) Pers.
Ballota nigra L.
Balsamita suaveolens Desf.
Quebracho
Tragacantha shrub
Bilimbi
Starfruit
Carqueja (Spanish name)
Black hempnettle
Costmary
Berberis vulgaris L.
Beta vulgaris L.
Barberry
Beet
Betonica officinalis L.
Betula lenta L.
Betula pendula Roth
Bixa orellana L.
Boronia megastigma Nees ex Bartl.
Boswellia spp.
Brassica napus L.
Wood betony
Wintergreen
european white birch
Anatto shrub
Boronia
Olibanum tree
Colewort
FEMA
3114 (wormwood); 3115 (extract); 3116 (oil)
US FDA
CFR.21 §172.510 (In alcoholic
beverages only)
CFR.21 §182.10
CFR.21 §172.510 (In alcoholic
beverages only)
2412 (estragon oil); 3043 (Tarragon)
CFR.21 §172.510 (finished food
thujone free)
CFR.21 §182.10; CFR.21 §182.20
2359 (oil)
CFR.21 §172.510
3023 (oil)
CFR.21 §172.510
2972 (bark extract)
3079 (gum)
CFR.21 §172.510 (In alcoholic
beverages only)
CFR.21 §172.510
CFR.21 §184.1351
CFR.21 §172.510 (in alcoholic
beverages only)
4229 (juice extract)
2154 (oil)
2103 (extract); 2104 (seed)
2167 (flowers absolute)
2816 (essential oil)
CFR.21 §172.510
CFR.21 §172.510
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COE
COE58; COE75
COE145
COE59
COE60
COE61
COE64
COE71A
COE2011
COE68
COE69
COE70
COE66
COE71
COE72
COE73
COE74
COE76
COE2013
COE530; COE2010;
COE2014
COE77; COE1003
COE78
COE79
COE82
COE83
COE495; COE2015;
COE84
COE445
COE86
COE496; COE541;
COE2016;
COE87
COE89
COE88
COE90
COE91
COE93
COE94
4/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Brassica nigra (L.) Koch
Brassica oleracea L.
Brassica oleracea var botrytis L.
Bryonia alba L.
English Name
Black mustard
Wild cabbage
Cauliflower
Bryonia, white or common
Buddleia spp.
Bulnesia sarmientoi Lorentz ex Griseb.
Bursera spp. and Protium spp.
Caesalpinia echinata Lam.
Calamintha officinalis Moench
Calendula officinalis L.
Calluna vulgaris (L.) Hull
Camellia sinensis (L.) Kuntze
Buddleia
Guaiac
Linaloe tree
Brazil wood;
Wild basil
Marigold
Common heather
Tea bush
Cananga odorata (Lam) Hook. & Thomson
Canarium spp.
Canella alba Murray
Capparis spinosa L.
Capsicum annuum L.
Ylang-Ylang
Elemi
White canella
Caper bush
Paprika
Capsicum frutescens L.
Cayenne pepper
Carica papaya L.
Carthamus tinctorius L.
Carum carvi L.
Carya illinoinensis (Wangenh.) K.Koch
Papaw tree
Safflower
Caraway
Pecan nuts
Cassia acutifolia Delile
Senna
Cassia burmanii Weight
Cassia fistula L.
Castanea dentata (Marsh.) Borkh.
Castor fiber L.
Indonesian cinnamon
Purging cassia
Chestnut
castoreum
Cedrus atlantica (Endl.) G.Manetti ex Carrière
Cedrus deodara (Roxb. ex D.Don) G.Don
Cedrus libani A.Rich.
Centaurea centaurium L.
Centaurea cyanus L.
Morrocan cedarwood
Himalaya cedarwood
Cedar of Lebanon
Large centaury
Cornflower
FEMA
2760 (Brassica Spp.)
US FDA
CFR.21 §182.10; CFR.21 §182.20
COE
COE95
COE2018
COE2019
CFR.21 §172.510 (In alcoholic
beverages only)
COE2020
2533 (wood extract); 2534 (wood, oil)
2634 (wood oil)
CFR.21 §172.510
CFR.21 §172.510
2658 (flower oil)
CFR.21 §182.10
4812 (palmitoylated green tea extract catechins) CFR.21 §182.20
2232 (cananga oil); 3119 (ylang ylang oil)
2407 (gum); 2408 (oil)
CFR.21 §182.20
CFR.21 §172.510
CFR.21 §182.10
2233 (extract); 2234 (oleoresin); 2266 (cayenne); CFR.21 §182.10; CFR.21 §182.20
2833 (paprika extract); 2834 (paprika oleoresin);
2849 (red pepper)
2233 (extract); 2234 (oleoresin); 2849 (pepper, CFR.21 §182.10; CFR.21 §182.20
red);
2236 (caraway); 2238 (oil)
4385 (shell flour)
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §172.510
2261 (extract, oil); 2262 (liquid)
CFR.21 §172.510
CFR.21 §182.50
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COE236
COE98
COE99
COE101
COE102
COE451
COE103; COE103B
COE104
COE105
COE106
COE107
COE108
COE109
COE110
COE112
COE523; COE560;
COE1130; COE2021;
COE114; COE114A;
COE524; COE561; COE605;
COE1140; COE2022
COE497; COE2023;
COE115
COE2024
COE554; COE1002;
COE3002; COEII (Castor)
COE2025
COE2026
COE117
COE118
COE119
5/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Centaurium umbellatum Gilib
Centaury
English Name
FEMA
Ceratonia siliqua L.
Carob tree
Cetraria islandica (L.) Ach.
Iceland moss
Chaenomeles speciosa (Sweet) Nakai
Chelidonium majus L.
Chimaphila umbellata (L.) Nutt.
Chondrus crispus (L.) Stackh.
Chrysanthemum morifolium Ramat.
Chrysanthemum parthenium (L) Bernh.
Cichorium intybus L.
Cinchona spp.
Greater celandine
Ground ivy
Irish moss
Chrysanthemum
Common pellitory
Chicory
Yellow cinchona
Cinchona succirubra Pav. ex Klotzsch
Red cinchona
2281 (bark, red); 2282 (bark, red, extract); 2285
(extract)
Cinnamomum burmannii Blume
Cinnamomum camphora (L.) Nees & Eberm.
Batavia cinnamon
Camphor tree
2289 (cinnamon)
2231 (camphor oil);
Cinnamomum cassia (L.) Blume
Cassia
2257 (bark extract); 2258 (bark oil); 2256 (cassia); CFR.21 §182.10; CFR.21 §182.20
2259 (buds); 2289 (cinnamon); 2290 (bark
extract); 2291 (bark oil);2292 (leaf oil)
Cinnamomum glaucescens (Nees) Hand.-Mazz.
Cinnamomum loureiroi Nees
Cinnamon
Cinnamon of Saigon
Cinnamomum spp.
Cinnamon
Cinnamomum zeylanicum Blume
Cinnamon
Cistus spp.
Citrullus lanatus (Thun.) Mansf.
Citrus × latifolia (Yu.Tanaka) Yu.Tanaka
Labdanum
Great water melon
Tahiti lime
2289 (cinnamon)
2289 (cinnamon); 2290 (bark extract); 2291 (bark
oil);2292 (leaf oil)
2289 (cinnamon); 2290 (bark extract); 2291 (bark
oil); 2292 (leaf oil)
2289 (cinnamon); 2290 (bark extract); 2291 (bark
oil);2292 (leaf oil)
2608 (absolute); 2609 (oil); 2610 (oleoresin);
Citrus × tangelo J.W.Ingram & H.E.Moore
Citrus auranthium ssp. amara var. pumilia
Tangelo
Myrtle-leaved orange tree
2243 (carob bean extract); 2648 (locust gum)
US FDA
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §182.20; CFR.21 §184.1343
CFR.21 §172.510 (in alcoholic
beverages only)
COE
COE120
COE121
4932 (leaf extract)
2914 (pipsissewa leaves extract)
2596 (extract)
4689 (extract)
4837 (extract)
2280 (extract)
2283 (bark); 2284 (bark extract); 2285 (extract);
2318 (peel extract); 4744 (Persian lime oil,
expressed); 4849 (terpenes)
4854 (oil)
2318 (peel extract)
CFR.21 §182.20
CFR.21 §182.20
CFR.21 §172.510 (In beverages only;
not more than 83 ppm total
cinchona alkaloids in finished
beverages)
CFR.21 §172.510 (In beverages only;
not more than 83 ppm total
cinchona alkaloids in finished
beverages)
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §172.510 (safrole free)
CFR.21 §182.10; CFR.21 §182.20
COE122
COE124
COE125
COE382
COE127
COE2027
COE128
COE129
COE130; COE130a;
COE130b
COE131
COE132
CFR.21 §182.20
CFR.21 §182.10; CFR.21 §182.20
COE133
CFR.21 §172.510
COE134
COE135
CFR.21 §182.20
COE138
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6/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Citrus aurantiifolia (Christm.) Swingle
Lime
English Name
FEMA
US FDA
2631 (essential oil, expressed); 2632 (oil,
CFR.21 §182.20
terpeneless); 2318 (peel extract); 4743 (Mexican
lime oil, expressed); 4849 (terpenes)
Citrus aurantium L.
Bitter orange
2344 (curacao peel extract); 2345 (curacao peel CFR.21 §182.20
oil); 2771 (neroli bigarde oil); 2819 (orange
flowers); 2820 (orange leaf absolute); 2823
(orange peel oil, bitter); 2818 (orange flowers
absolute); 2855 (petitgrain paraguay oil); 2318
(citrus peel oil); 4853 (petitgrain oil, terpeneless)
Citrus aurantium L. subspecies cyathifera Y
Citrus bergamia (Risso & Poiteau)
Daidai
Bergamot
3823 (peel oil); 2318 (peel extract)
2153 (essential oil of rind); 2318 (peel extract)
Citrus clementina Hort. ex Tanaka
Citrus depressa Hayata
Citrus hassaku hort. ex Tanaka
Citrus iyo Tanaka
Citrus japonica Thun
Citrus junos Sieb ex Tanaka
Citrus limon (L.) Burm. f.
Algerian clementine
Sikuwasya
Hassaku
Iyokan
Kumquat
Yuzu
Lemon tree
4855 (oil)
4859 (oil)
4858 (oil)
4857 (oil)
2318 (peel extract); 4862 (oil)
2318 (peel extract); 2623 (extract); 2625 (oil);
2626 (oil terpeneless); 2853 (lemon petitgrain
oil); 4848 (terpenes); 4852 (essence oil)
CFR.21 §182.20
CFR.21 §182.20
Citrus maxima (J. Burman) Merr.
Citrus medica L.
Citrus medicus L. var. sarcodactylus Swingle
Citrus microcarpa Bunge
Citrus natsudaidai (Yu.Tanaka) Hayata
Citrus paradisi Macfad.
Pummelo
citron tree
Sarcodactylis
Calamondin
Natsumikan
Grapefruit
CFR.21 §182.20
COE140; COE2037
COE2035
CFR.21 §182.20
COE498
Citrus reticulata Blanco
Mandarin
Citrus reticulata Blanco 'Ponkan'
Citrus reticulata Blanco var. unshiu (Marco.)
H.H.Hu
Ponkan
Satsuma mandarine
2318 (peel extract)
4849 (terpenes)
2318 (peel extract); 3899 (oil)
2318 (peel extract)
4860 (oil)
2318 (peel extract); 2530 (oil); 2769 (naringin
extract); 4846 (essence oil); 4847 (oil,
terpeneless); 4851 (terpenes)
2318 (peel extract); 2657 (mandarin oil,
expressed); 2854 (Petitgrain mandarin oil); 3041
(oil)
4865 (oil)
2318 (peel extract)
CFR.21 §182.20
CFR.21 §182.20
COE
COE141
COE136; COE136A;
COE136B; COE136C
COE137
COE2031a
COE2032
COE139; COE139A;
COE139B; COE525;
COE1410; COE2034;
CFR.21 §182.20
CFR.21 §182.20
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COE142; COE2039
COE604; COE2031;
7/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Citrus sinensis (L.) Osbeck
English Name
Sweet orange
FEMA
2821 (orange distilled oil); 2822 (orange oil
terpeneless); 2824 (orange peel extract); 2825
(orange cold pressed oil); 2826 (orange peel oil,
terpeneless); 2318 (peel extract); 4850
(terpenes); 4856 (Blood orange oil); 4866
(essence water phase)
Citrus sphaerocarpa
Citrus spp.
Citrus sudachi hort. ex Shirai
Citrus unshiu Marcovitch
Citrus x meyeri
Clinopodium vulgare L.
Kabosu
Citrus
Sudachi
Mikan
Meyer lemon oil, cold pressed
Wild basil
4864 (oil)
2318 (peel extract)
4863 (oil)
4861 (oil)
4770 (oil, cold pressed)
Cnicus benedictus L.
Holy thistle
Coccus cacti L.
Cocos nucifera L.
Coffea canephora Pierre ex Froehner
Coffea spp.
Cola acuminata (P.Beauv.) Schott & Endl.
Cola nitida (Vent.) Schott & Endl.
Commiphora spp.
Convolvulus scoparius L.f.
Copaifera officinalis L.
Coptis teeta Wall.
Cordyceps sinensis
Coriandrum sativum L.
Corylus avellana L.
Corynebacterium ammoniagenes
Corynebacterium glutamicum
Carmine
Coconut
Coffee
Coffee
Kola
Kola
Myrrh
Rose wood
Copaiba
Gold thread
Coriander
Hazelnut tree
US FDA
CFR.21 §182.20
COE
COE143
CFR.21 §182.20
CFR.21 §172.510 (In alcoholic
beverages only)
COE526; COE2040;
COE3700;
COE144
2242 (Carmine)
2607 (nut extract)
2765 (gum); 2766 (oil);
CFR.21 §182.20
CFR.21 §182.20
CFR.21 §182.20
CFR.21 §172.510
CFR.21 §172.510
4878 (fermentation product)
2333 (coriander); 2334 (oil)
CFR.21 §182.10; CFR.21 §182.20
COE147
COE148A
COE148
COE 149
COE 2041
COE150
COE152
COE499; COE2043;
COE153
COE154
COE155
4949 (fermentation product)
4907 (corn syrup fermentation product); 4964
(cell free/dried fermentation broth)
4908 (corn syrup fermentation product)
Corynebacterium stationis
Crataegus oxyacantha L.
Crocus sativus L.
Croton spp.
Cryptocarya massoy (Oken) Kosterm.
Hawthorn
Saffron
Cascarilla tree
Massoia
Cucumis melo L.
Cucumis sativus L.
Cuminum cyminum L.
Cupressus sempervirens L.
Sweet melon
Cucumber
Cumin
Cypress
2998 (saffron); 2999 (extract)
2254 (bark extract); 2255 (bark oil)
3747 (bark oil)
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §182.20
2340 (seed); 2343 (seed oil)
CFR.21 §182.10; CFR.21 §182.20
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COE156
COE157
COE158
COE500; COE2029;
COE2044;
COE159
COE160
COE161
COE162
8/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Curcuma longa L.
Latin Name
Turmeric
English Name
FEMA
US FDA
3085 (powder); 3086 (extract); 3087 (oleoresin); CFR.21 §182.10; CFR.21 §182.20
Curcuma zedoaria (Christm.) Roscoe
Cyamopsis tetragonoloba (L.) Taub.
Cydonia spp.
Cymbopogon citratus Stapf. A.P. Decandolle
Cymbopogon flexuosus (Nees ex Steud.)
W.Watson
Cymbopogon martinii (Roxb) W. Wats. Var motia
Cymbopogon nardus (L.) Rendle
Cymbopogon winterianus Jowitt ex Bor
Cynara cardunculus L.
Cynara scolymus L.
Zedoary
Guar
Quince
West Indian Lemongrass
Lemongrass, east indian
3122 (zedoary); 3123 (bark extract)
2537 (gum)
2974 (extract of seeds)
2624 (oil)
2624 (oil)
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §184.1339
CFR.21 §182.40
CFR.21 §182.20
CFR.21 §182.20
COE164
Palmarosa
Citronella
2831 (oil)
2308 (oil)
2308 (oil)
CFR.21 §182.20
CFR.21 §182.20
COE40; COE2046
COE39; COE2046A
Cyphomandra betaceae (Chv.) Sendt
Cytisus scoparius Link.
Daemonorops draco Blume
Tomato tree
Common broom
Dragon
Dammara Australis
Daucus carota L.
Decalepis hamiltonii
Dianthus caryophyllus L.
Dictamnus albus L.
Cowrie
Carrot
Swallowroot
Carnation
White dittany
Dicypellium caryophyllatum Nees
Diospyros kaki Thunb.
Dipterix odorata (Aublet) Will.
Dipterocarpus spp.
Eleagnus angustifolia L.
Eleagnus commutata Bernh. Ex Rubd.
Eleagnus multiflora Thunb
Eleagnus multiflora Thunb var multiflora
Eleagnus umbellata Thunb.
Elettaria cardamomum (L.) Maton
Erica cinerea L.
Clove bark
Kaki
Tonquin bean
Gurjun
Oleaster
Silverberry
Goumi
Goumi
Autumn olive
Cardamom
Bell heather
Erigeron canadensis L.
Eriobotrya japonica
Eriodictyon californicum (Hook. & Arn.) Torr.
Erythraea centaurium Pers.
Erythroxylum coca Lam.
Eucalyptus citriodora Hook.
Eucalyptus diversicolor F.v.Muell.
Erigeron
Biwa
Santa herb
Small centaury
Coca
Eucalyptus citriodora
Karri
Cardoon
Artichoke
CFR.21 §172.510 (in alcoholic
beverages only)
2404 (extract)
CFR.21 §172.510
2244 (seed oil)
4283 (extract)
CFR.21 §182.20
CFR.21 §172.510 (in alcoholic
beverages only)
2240 (cardamom); 2241 (seed oil)
CFR.21 §182.10; CFR.21 §182.20
2409 (oil)
4933 (leaves extract)
3118 (fluid extract)
CFR.21 §172.510
2329 (leaf extract, decocainized)
CFR.21 §182.20
CFR.21 §172.510
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COE
COE163
COE167
COE38
COE2045
COE168
COE168A; COE565;
COE1680; COE2047;
COE169
COE170
COE100; COE531;
COE2048;
COE16
COE173; COE173a
COE174
COE175
COE176
COE177
COE178
COE2049
COE501; COE2050
COE502; COE2051;
COE503
COE504; COE2052;
COE505; COE2053;
COE180
COE102A; COE559;
COE1020; COE2054;
COE181
COE182
COE183
COE184
COE186
COE2055
9/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Eucalyptus globulus Labill.
Eucalyptus occidentalis Endl.
Eugenia jambolana Lam.
Eugenia malaccensis L.
Eugenia spp.
English Name
Eucalyptus
Flat topped yate
Jambul
Malay apple
Clove bud
Eugenia uniflora L.
Eupatoria triplinerve Vahl.
Euphrasia officinalis L.
Euryganium sumbul
Euterpe oleracea Mart.
Evernia prunastri (L.) Ach.
Brazillian cherry
White snakeroot
Eyebright
Sumbul
Acai berry
Oak moss
4547 (berry extract)
2795 (absolute)
Fallopia dumetorum (L.) Holub
Ferula assa-foetida L.
Desert-knot grass
Asafoetida
2106 (fluid extract); 2107 (gum); 2108 (oil);
CFR.21 §182.20
Ferula ceratophylla Regel et Schmal.
Ferula galbaniflua Boiss. et Buhse
Ferula rubricalis Boiss.
Ficus carica L.
Foeniculum vulgare Mill, ssp. piperitum (Ucria)
Countinho
Foeniculum vulgare Mill.
Foeniculum vulgare Mill. var. dulce (DC.) Alef.
Fomes officinalis (Vill. Fr.) Ames
Galbanum
Galbanum
Gum called asafoetida
Fig tree
Bitter fennel
2501 (oil); 2502 (resin)
CFR.21 §172.510
2481 (extract)
2482 (sweet fennel); 2483 (oil)
CFR.21 §182.10
CFR.21 §182.10; CFR.21 §182.20
Fragaria vesca L.
Fragaria virginiana
Fraxinus excelsior L.
Fucus vesiculosus L.
Fumaria officinalis L.
Galeopsis ochroleuca Lam.
Galipea officinalis J. Hancock
Gallus gallus var. domesticus
Garcinia mangostana L.
Gardenia gummifera L.f.
Gardenia jasminoides J.Ellis
Gaultheria procumbens L.
Gelidium ssp Euchama Euchama J. A.G.
Wild strawberry
Strawberry
Common ash
Bladder wrack
Fumitory
Hollow tooth herb
Angostura
Egg
Mangosteen tree
Gardenia gummifera
Gardenia
Wintergreen
Agar-agar
2092 (extract)
CFR.21 §182.10; CFR.21 §182.20
Gentiana acaulis L.
Dwarf gentian
Common Fennel
Sweet fennel
Larch agaric
FEMA
2466 (oil)
2322 (bud extract); 2323 (bud oil); 2324 (bud
oleoresin); 2325 (leaf oil); 2327 (cloves); 2328
(stem oil);
US FDA
CFR.21 §172.510
COE
COE185
COE2056
COE442
COE189
CFR.21 §182.20; CFR.21 §184.1257;
CFR.21 §182.10; CFR.21 §184.1257
COE190
COE191
COE192
COE193
CFR.21 §172.510 (finished food
thujone free)
4757 (distillate)
4265 (distillate)
3112 (extract); 3113 (oil)
2012 (agar)
COE194; COE2057
COE357
COE196
COE2060
COE197
COE2061
COE198
COE201; COE201A
COE200
COE527; COE2061A;
COE2069;
COE203
COE202
COE204
COE206
COE207
COE208
COE165
COEIII (egg)
COE209
COE210
COE211
CFR.21 §184.1115 (in certain foods
with limits)
CFR.21 §172.510 (in alcoholic
beverages only)
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COE213
10/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Gentiana lutea L.
Glechoma hederacea L.
Glycine max (L.) Merr.
Glycyrrhiza glabra L.
English Name
Gentian
Ivy
Soybean; Soya bean; Soya
Licorice
Gnaphallium dioicum L.
Guaiacum officinale L.
Cat's foot
Guaiac wood
Guaiacum sanctum L.
Holywood Lignum Vitae
Haematoxylon campechianum L.
Hamamelis virginiana L.
Hedeoma pulegioides (L.) Pers.
Hedychium flavum
Helianthus anuus L.
Helichrysum angustifolium DC.
Helichrysum arenarium Moench.
Heliopsis longipes S.F. Blake
Herniaria glabra L.
Hibiscus esculentus L.
Hibiscus sabdariffa L.
Peach wood
Winter bloom
Pennyroyal
Longose
Sunflower
Immortelle
Everlasting flower
Chilcaun; Gold root
Rupturewort
Ladies' Fingers plant
Roselle
Hierochloe odorata (L.) Beauv.
Hippophae rhamnoides L.
Hordeum vulgare L.
Humulus lupulus L.
Holy grass
Sea buckthorn
Barley
Hops
Hyacinthus orientalis L.
Hydrangea macrophylla (Thunb.) Ser.
Hypericum perforatum L.
Hyacinth flowers
Amacha
St. John's wort
Hyssopus officinalis L.
Ilex paraguariensis A.St.-Hil.
Illicium verum Hook.f.
Indigofera tinctoria L.
Inula dysenterica
Inula helenium L.
Hyssop
Mate
Star anise
True indigo
Common fleabane
Elecampane
FEMA
2506 (root extract)
4919 (Refined soybean oil extract)
2628 (liquorice extract) 2528 (glycyrrhizin
ammoniated); 2629 (extract); 2630 (root)
US FDA
CFR.21 §172.510
CFR.21 §184.1408
2531 (gum extract); 2533 (wood extract); 2534
CFR.21 §172.510
(wood, oil); 4942 (modified guaiac wood extract)
2531 (gum extract); 2533 (wood extract); 2534
CFR.21 §172.510
(wood, oil); 4942 (modified guaiac wood extract)
2839 (oil)
CFR.21 §172.510
2592 (extract)
CFR.21 §182.20
COE
COE214
COE216
COE 217
COE218
COE219
COE 97
COE 220
COE221
COE222
COE223
COE224
COE2063
COE225
4220 (extract)
4912 (Hibiscus blossom extract)
2578 (extract); 2579 (extract solid); 2580 (oil)
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §182.20
COE227
COE228
COE229
COE230
COE231
COE232
COE233
CFR.21 §172.510
4737 (leaves extract)
2589 (Hyssop); 2590 (extract); 2591 (oil);
4969 (extract)
2095 (star anise); 2096 (oil)
CFR.21 §172.510 (Hypericin-free
alcohol distillate form only; In
alcoholic beverages only)
COE234
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §182.20
CFR.21 §182.10
COE235
COE237
COE238
COE532; COE2064;
COE239
COE240
CFR.21 §172.510 (in alcoholic
beverages only)
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11/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
English Name
FEMA
2829 (concrete liquid oil); 2830 (root extract)
US FDA
CFR.21 §172.510
COE241
COE
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §182.20
COE242
COE243
COE244
COE245
Iris florentina L.
Orris
Iris foetidissima L.
Iris germanica L.
Iris pallida Lam.
Jasminum grandiflorum L.
Stinking irris gladdon
German flag
Pale flag
Jasmine
Jasminum officinale L.
Jateorhiza palmata (Lam.) Miers
White jasmin
Colombo
Juglans spp.
Juglans virginiana
Juniperus communis L.
Juniperus mexicana Spreng
Juniperus oxycedrus L.
Juniperus procera Hochst. Hochstter ex Endl.
Juniperus sabina L.
Juniperus virginiana L.
Krameria triandra Ruiz. &Pav. & Krameria
argentea Mart. ex Spreng.
Laminaria and Nereocystis spp.
Walnut tree
American walnut
Juniper
Texas cedarwood
Cade
Cedarwood east african
Savin
Red cedar
Rhatany
3111 (hull, leaf or shell extract)
CFR.21 §182.20
CFR.21 §172.510 (In alcoholic
beverages only)
CFR.21 §172.510
2602 (berries); 2603 (extract); 2604 (oil);
CFR.21 §182.20
2979 (extract)
CFR.21 §172.510
Sea tangle
2606 (kelp); 2014 (algin)
CFR.21 §184.1120
Larix decidua Mill.
Larrea mexicana Moric.
Laurus nobilis L.
Common larch
Creosote bush
Bay laurel
CFR.21 §182.10; CFR.21 §182.20
Lavandula hybrida
Lavandula latifolia Medik.
Lavandula officinalis Chaix
Lavandin
Spike lavender
Lavender
2124 (sweet bay leaves); 2125 (sweet bay leaves
oil); 2612 (laurel berries); 2613 (sweet bay leaves
extract);
2618 (oil)
3033 (oil)
2619 (lavender); 2620 (absolute); 2621
(concrete); 2622 (oil);
COE533; COE2068
(Laminiaria digitata);
COE534; COE2070;
COE254
COE255
CFR.21 §182.20
CFR.21 §182.20
CFR.21 §182.10; CFR.21 §182.20
COE2071
COE256
COE257
Lavandula stoechas L.
Lawsonia alba Lam.
Leptospermum citratum Forst
Levisticum officinale Koch.
Liatris odoratissima Willd.
Ligusticum mutellina (L.) Crantz
Linum usitatissimum L.
Lippia citriodora Kunth.
Roman Lavender
Henna
Tea-tree
Lovage
Deertongue
Mountain lovage
Linseed
Lemon verbena
CFR.21 §182.10
COE258
COE259
COE260
COE261
COE262
COE2074C
COE263
COE264
Liquidambar styraciflua L.
Litchi chinensis Radl.
Litsea cubeba (Lour.) Pers.
Storax
Litchi
Litsea cubeba
2598 (absolute); 2599 (concrete); 2600 (oil);
2601(spiritus)
2649 (lovage); 2650 (extract); 2651 (oil);
CFR.21 §172.510
3036 (Storax); 3037 (extract)
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §172.510
3846 (oil)
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COE246
COE247
COE248
COE507; COE2065
COE249
COE2066
COE250
COE251
COE2067
COE252
COE253
COE265
COE304
COE491
12/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Lobaria pulmonaria (L.) Hoffm.
Lonicera caprifolium L.
Lonicera japonica Thunb.
Lycopersicum esculentum Mill.
Macrocystis pyrifera
Mallotus philipensis (Lam.) Muell. Arg.
Malus Sylvestris Mill. Var. Domestica (Borkhausen)
Mansfeld
Malva silvestris L.
Mammea americana L.
Mangifera indica L.
Manilkara zapota (L.) Royen
Marrubium vulgare L.
Marsdenia condurango Rehb.
Matricaria chamomilla L.
Medicago sativa L.
Melaleuca alternifolia Cheel.
Melaleuca leucadendron (L.) L.
Melaleuca linariifolia Smith
Melilotus coerulea (L.) Desr.
Melilotus officinalis (L.) Lam.
Melissa officinalis L.
English Name
Lungwort lichen
Honeysuckle
Honeysuckle
Tomato
Giant kelp
Kamala tree
Apple tree
Melittis melissophyllum L.
Mentha aquatica L.
Mentha arvensis L.
Bastard balm
Watermint
Cornmint
Mentha cardiaca J. Gerard ex Baker
Scotch spearmint
Mentha piperita L.
Peppermint
4221 (spearmint oil, scotch); 4811 (ginger mint
oil)
2847 (leaves); 2848 (oil); 4924 (oil terpeneless)
Mentha pulegium L.
Mentha silvestris L.
Pennyroyal
Horsemint
2839 (oil)
4756 (oil)
Mentha spicata L.
Crisped mint; Erospicata
3030 (spearmint); 3031 (extract); 3032 (oil); 4777 CFR.21 §182.10; CFR.21 §182.20
(erospicata oil); 4925 (oil terpeneless)
Mentha spicata var. crispa
Mentha viridis L.
Curly mint
Spearmint
4778 (curly mint oil)
3030 (spearmint); 3031 (extract); 3032 (oil)
Mallow
Mammee tree
Mango tree
Sapodilla plum
White hoarhound
Kondurango
Camomile
Alfalfa
Tea tree
Cajuput
Tea-tree
Sweet trefoil
Melilot
Melissa balm
FEMA
US FDA
CFR.21 §172.510
COE
COE438
COE266
4690 (extract)
COE267
COE2072
COE535; COE2073;
COE386
2581 (extract)
CFR.21 §182.10; CFR.21 §182.20
2273 (flower oil)
2013 (extract)
3902 (oil)
2225 (oil)
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §182.10; CFR.21 §182.20
4727 (herb distillate)
2111 (balm); 2112 (balm leaves extract); 2113
(balm oil)
CFR.21 §172.510
CFR.21 §182.10; CFR.21 §182.20
COE268
COE269
COE270
COE423
COE271
COE272
COE273
COE274
COE275
COE276
COE277
COE278
COE279
COE280
COE281
4873 (extract)
4219 (oil)
COE492; COE508;
COE2074;
COE285b
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §172.510
CFR.21 §182.20
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COE282; COE509;
COE2074a
COE283
COE284 (Mentha
silvestris); COE284b
(Mentha longifolia var.
crispa; COE284a (Mentha
longifolia var. longifolia);
COE285
COE286
13/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Menyanthes trifoliata L.
Buckbean
English Name
Mespilus germanica L.
Meum athamanticum Jacq.
Michelia alba DC.
Michelia champaca L.
Monarda punctata L.
Monarda spp.
Monodora myristica Dun.
Morus alba L.
Morus indica L.
Moschus moschiferus L.
Murraya koenigii (L.) Spreng.
Musa species
Myosotis palustris Lam.
Myrica gale L.
Myrica pensylvanica Loisel.
Myristica fragrans Houtt.
Medlar tree
Bladmoney
Ginkoboku
Champac
American horsemint
Horsemint
Jamaica nutmeg
Mulberry tree, white and black
Eastern mulberry
Musk
Indian curry leaf tree
Banana
Forget-me-not
sweet gale
Bayberry
Mace
Myroxylon balsamum (L.) Harms
Tolu balsam
Myroxylon balsamum var. pereirae (Royle) Harms Peru balsam
Myrrhis odorata (L.) Scop.
Myrtus communis L.
Sweet chervil
Myrtle
Narcissus jonquilla L.
Narcissus poeticus L.
Narcissus tazetta L.
Nardostachys jatamansi (D. Don) DC
Nasturtium officinale L.
Nepeta cataria L.
Nephelium lappaceum L.
Nephelium longanum Cambess
Nicotiana tabacum L.
Nigella damascena L.
Nigella sativa L.
Ocetea pretiosa (Nees.) Mez.
Ocimum basilicum L.
Olea europaea L.
Oleanthus gamwelliae
Ononis arvensis L.
Opopanax chironium Koch.
Daffodil
Narcissus
Cream narcissus
Spikenard
Watercress
Catmint
Ramboutan
Longane
Common tobacco
Love-in-a-mist
Black caraway
Brasilian sassafras
Basil
Olive tree
Nindi
Common restharrow
Opopanax
FEMA
US FDA
CFR.21 §172.510 (In alcoholic
beverages only)
COE
COE287
COE288
COE510; COE2075
3950 (oil)
2582 (leaves extract)
2582 (leaves extract)
CFR.21 §182.20
COE289
COE290
COE291
COE292; COE292a
COE293
2759 (musk tonquin)
CFR.21 §182.50
2652 (mace); 2653 (mace oil); 2654 (mace
oleoresin); 2792 (nutmeg); 2793 (nutmeg oil)
CFR.21 §182.10; CFR.21 §182.20
COE520; COE2076
COE294
COE295
COE549; COE2077;
COE2078
COE296
3069 (extract); 3070 (gum)
2116 (balsam); 2117 (oil)
CFR.21 §172.510
CFR.21 §182.20
COE297
COE298
CFR.21 §172.510 (in alcoholic
beverages only)
2342 (black cumin); 2237 (carraway)
CFR.21 §182.10
2118 (basil); 2119 (oil); 2120 (oleoresin)
4801 (olive fruit extract)
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §172.510
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COE299
COE300
COE2079
COE2080
COE2081
COE2082
COE301
COE302
COE303
COE305
COE512; COE2083;
COE306
COE307
COE2084
COE308
COE309
COE310
COE311
COE313; COE2042
14/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Origanum creticum L.
Origanum dictamnus L.
Origanum majorana L.
English Name
Spanish marjoram
Dittany of Crete
Marjoram
Origanum vulgare L.
Ormensis multicaulis
Osmanthus fragrans Lour.
Wild marjoram
Chamomille, wild Morrocco
Osmanthus
Panax quinquefolius L.
Pandanus latifolius Hassk.
Papaver rhoeas L.
Papaver somniferum L.
Passiflora edulis Sims.
Pastinaca sativa L.
Paullinia cupana Kunth
Pedilanthus spp.
Pelargonium graveolens L'Hér.
Perilla frutescens (L.) Britt
Persea americana Mill.
Persicaria bistorta (L.) Samp.
Persicaria odorata
Petroselinum spp.
Peucedanum ostruthium Koch.
Peumus boldus Molina
American ginseng
Pandanus
Red poppy
White poppy
Passion flower
Parsnip
Guarana shrub
Candelilla
Rose geranium
Perilla
Avocado
Bistort
Vietnamese cilantro
Parsley
Imperatoria
Boldo tree
Phaseolus mungo L.
Phaseolus vulgaris L.
Phoenix dactylifera L.
Physalis alkekengi L.
Mung bean
Common bean
Date palm
Strawberry tomato
Physalis peruviana L.
Physeter macrocephalus L.
Cape gooseberry
Ambergris
Picea excelsa Link.
Picea mariana (Mill.) Britton, Sterns & Poggenb.
Picramnia antidesma Sw.
Pimenta officinalis Lindl.
Blue pine
Black spruce
West Indian cascara
Allspice
Pimenta racemosa (Mill.) J.W. Moore
Pimpinella anisum L.
Pimpinella saxifraga L.
Pinus laricio Poir.
Pinus mugo Turra
Bay
Anise
Burnet-saxifrage
Black pine
Mountain pine
FEMA
2399 (dittany of crete)
2659 (oleoresin); 2661 (seed); 2662 (sweet
marjoram); 2663 (oil) ;
2660 (marjoram pot)
US FDA
CFR.21 §172.510
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §182.10
3750 (absolute)
2919 (seed)
CFR.21 §182.10
CFR.21 §172.510
2536 (gum)
3479 (wax from stem and branches)
2508 (oil)
4013 (leaf oil)
CFR.21 §172.510
CFR.21 §184.1976
CFR.21 §182.20
4736 (oil)
2835 (parsley); 2836 (oil); 2837 (oleoresin)
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §172.510
CFR.21 §172.510 (In alcoholic
beverages only)
2049 (tincture)
CFR.21 §182.50
3034 (oil)
CFR.21 §172.510
2017 (allspice); 2018 (oil); 2019 (oleoresin); 2901 CFR.21 §182.10; CFR.21 §182.20
(pimenta leaf oil)
2121 (extract); 2122 (oil); 2123 (oleoresin);
CFR.21 §182.20
2093 (anise); 2094 (oil)
CFR.21 §182.10; CFR.21 §182.20
2904 (needle oil)
CFR.21 §172.510
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COE
COE314
COE315
COE316
COE317
COE2085
COE513; COE521;
COE2086;
COE2087a
COE2088
COE319
COE320
COE321; COE2809
COE322
COE323
COE490
COE324
COE514; COE2090
COE325
COE356
COE326
COE327
COE328
COE537; COE2058;
COE538; COE2059;
COE329
COE528; COE567;
COE2091; COE3290;
COE330
COE557; COE1005; COEV
(ambergris)
COE331
COE333
COE335
COE334
COE336
COE337
COE338
COE339
15/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Pinus palustris Mill.
Latin Name
English Name
Longleaf pine
FEMA
2907 (oil); 3089 (steam distilled)
US FDA
CFR.21 §172.510 (Rosin, Colophony: COE340
in alcoholic beverages only. No
limitations for oils); CFR.21 §172.515
Pinus spp.
Turpentine
2907 (oil); 3088 (gum); 3089 (steam distilled)
CFR.21 §172.510 (Rosin, Colophony:
in alcoholic beverages only. No
limitations for oils); CFR.21 §172.515
Pinus strobus L.
White pine
Pinus succinifera Conev.
Pinus sylvestris L.
Piper angustifolium Ruiz. & Pav.
Piper cubeba L.f.
Piper longum L.
Piper nigrum L.
Baltic amber
Pine
Matico
Cubeb
Long peper
Black pepper
Pistacia lentiscus L.
Pistacia terebinthus L.
Pistacia vera L.
Plantago lanceolata L.
Pogostemon cablin (Blanco) Benth.
Polianthes tuberosa L.
Polygala senega L.
Polygonum aviculare L.
Polyporus officinalis Fries
Populus alba L.
Populus nigra L.
Mastic tree
Turpentine
Pistachio
Small plantain
Patchouly
Tuberose
Senega root
Common knotgrass
White agaric
White poplar
Black poplar
Potentilla tormentilla Stokes
Prangos asperula Boiss.
Primula elatior L.
Prosopis cineraria (L.) Druce
Prunella vulgaris L.
Prunus amygdalus Batsch. V. dulcis
Prunus armeniaca L.
Prunus avium (L.) L.
Tormentil
Hay
Cowslip
Mesquite
Self-heal
Sweet almond tree
Apricot
Cherry
CFR.21 §172.510 (In alcoholic
beverages only)
2906 (oil)
CFR.21 §172.510
2338 (cubeb); 2339 (oil)
CFR.21 §172.510
4266 (distillate)
2844 (black pepper ); 2845 (black pepper oil);
CFR.21 §182.10; CFR.21 §182.20
2846 (black pepper oleoresin); 2850 (white
pepper oil); 2851 (white pepper oil); 2852 (white
pepper oleoresin);
2838 (oil)
3084 (oil)
CFR.21 §172.510
CFR.21 §182.20
CFR.21 §172.510 (in alcoholic
beverages only)
COE
COE342
COE343
COE341
COE344
COE345
COE346
COE347
COE349
COE350
COE351
COE352
COE353
COE354
COE355
COE 515; COE 2093
COE359
COE360
COE361
COE493
COE363
COE364; COE2095
3942 (wood extract)
2046 (oil)
2105 (apricot kernel, persic oil)
2278 (pits)
CFR.21 §182.20; CFR.21 §182.40
CFR.21 §172.510 (not to exceed 25
ppm Prussic acid)
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COE 365
COE367
COE368
COE369
16/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Prunus cerasus L.
Latin Name
English Name
Sour cherry
Prunus domestica L.
Prunus insititia L.
Prunus laurocerasus L.
Plum
Damson
Cherry laurel
Prunus persica (L.) Batsch
Peach
Prunus serotina Ehrh.
Prunus spinosa L.
Wild cherry
Sloe
Psalliota hortensis
Psidium guajava L.
Pterocarpus santalinus L.f.
mushroom
Guava
Red sandalwood tree
Pulmonaria officinalis L.
Punica granatum L.
Pyrus communis L.
Pyrus Domestica Gaernt.
Quassia amara L.
Quercus alba L.
Quercus ilex L.
Quercus robur L.
Lungwort
Pomegranate tree
Pear tree
Whitty pear
Quassia
White oak
Holm oak
Common red oak
Quercus spp.
Tannic acid
Quercus suber L.
Oak cork
Quillaja saponaria Molina
Raphanus sativus L.
Rhamnus cathartica L.
Rhamnus frangula L.
Rhamnus purshiana DC
Rheum hybridum Murr.
Rheum officinale Baill.
Soap bark tree
Winter radish
Buckthorn
Alder buckthorn
Cascara sagrada
Rhubarb
Medicinal rhubarb
Rheum palmatum L.
Rheum rhaponticum L.
Chinese rhubarb
Garden rhubarb
Rhodymenia palmata (L.) Grev.
Dulse
FEMA
2278 (pits extract)
2277 (oil)
2276 (bark extract)
3020 (sloe berries) 3021 (berries extract) 3022
(berries solid extract)
US FDA
CFR.21 §172.510 (not to exceed 25
ppm Prussic acid)
CFR.21 §172.510 (not to exceed 25
ppm Prussic acid)
CFR.21 §172.510 (In alcoholic
beverages only; not to exceed 25
ppm Prussic acid in the flavour);
CFR.21 §182.20; CFR.21 §182.40
(persic oil)
CFR.21 §182.20
CFR.21 §182.20
CFR.21 §182.20
CFR.21 §172.510 (in alcoholic
beverages only)
2918 (bark extract)
CFR.21 §182.20
2971 (extract)
2794 (chips extract)
CFR.21 §172.510
CFR.21 §172.510
3042 (tannic acids)
2973 (extract)
2253 (bitterless extract)
2405 (dulse)
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §184.1097 (in certain foods
with limits)
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §182.30
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COE
COE370
COE371
COE373
COE372
COE374
COE375
COE376
COE2097
COE377
COE379
COE380
COE381
COE384
COE385
COE332; COE2092
COE388
COE389
COE390
COE391
COE392
COE393
COE394
COE395
COE396A; COE569;
COE2098; COE3960;
COE396
COE397
17/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Ribes nigrum L.
Ribes rubrum L.
Ribes uva-crispa L. var. sativum D.C.
Ricinus communis L.
Roccella fuciformis Arch. R. tinctoria
English Name
Blackcurrant
Currant berry
Gooseberry
Castor oil
Angola weed
FEMA
Rosa canina L.
Rosa centifolia L.
Rosa damascena Mill.
Rosa spp.
Rosmarinus officinalis L.
Wild dog rose
Cabbage rose
Red rose
Rose
Rosemary
2990 (extract)
2988 (absolute); 2993 (stronger rose water)
2989 (flower oil)
2988 (absolute); 2990 (rosehip extract)
2991 (rosemary); 2992 (oil); 4705 (oleoresin)
CFR.21 §182.20
CFR.21 §182.20
CFR.21 §182.20
CFR.21 §182.10; CFR.21 §182.20
Rubus fruticosus L.
Rubus idaeus L.
Rubus suavissimus S. Lee
Blackberry
Raspberry
Sweet blackberry
2155 (bark extract)
CFR.21 §172.510
Rumex acutus L.
Rumex aquaticus L.
Ruta graveolens L.
Sharp-pointed-dock
Water dock
Common rue
2994 (rue); 2995 (oil)
CFR.21 §184.1699; CFR.21
§184.1698
Saccharomyces cerevisiae
Saccharum officinarum L.
Salvia lavandulifolia Vahl
Salvia officinalis L.
Salvia sclarea L.
Sambucus canadensis L.
Sambucus nigra L.
Beer yeast
Sugar cane
Spanish sage
Common Sage
Clary-sage
Elder
Black elder
4816 (distillate)
3003 (oil)
3000 (sage); 3001 (oil); 3002 (oleoresin)
2320 (clary sage); 2321 (oil)
2406 (flowers)
2406 (flowers)
CFR.21 §182.20 (Molasses, extract)
CFR.21 §182.20
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §172.510 (In alcoholic
beverages only; not to exceed 25
ppm Prussic acid in the flavour);
CFR.21 §182.20
Sanguinaria canadensis L.
Sanguisorba minor Scop.
Santalum album L.
Santalum austrocaledonicum
Santalum spicatum DC.
Santolina chamaecyparissus L.
Saponaria officinalis L.
Sassafras albidum Nutt. Nees
Canadian blood root
Salad burnet
Sandalwood
3005 (wood oil)
Sandalwood austracaledonicum 4815 (oil)
Australian sandalwood
Garden cypress
Soapwort
Sassafras
3010 (bark extract, safrole-free); 3011 (leaf
extract, safrole-free)
2346 (buds absolute)
2263 (castor oil)
US FDA
CFR.21 §172.510
COE
COE399
COE400
COE398
CFR.21 §172.510
CFR.21 §172.510 (in alcoholic
beverages only)
COE403
COE404
COE405; COE2099
COE406
COE408
COE409
4717 (leaves extract); 4800 (glucolsylated extract,
20-30% glucosylated rubusoside glycosides);
4814 (glucolsylated extract, 60% glucosylated
rubusoside glycosides)
CFR.21 §172.510
CFR.21 §172.510 (Safrole free);
CFR.21 §172.580
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COE410
COE411
COE412
COE 2099a
COE2100
COE413
COE414
COE415
COE416
COE417
COE418
COE547; COE2101;
COE420
COE187
COE421
COE422
COE424
18/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Satureja hortensis L.
English Name
Summer savory
Satureja montana L.
Winter savory
Saussurea lappa (Decne.) C.B.Clarke
Schinus molle L.
Scorzonera hispanica L.
Secale cereale L.
Sesamum indicum L.
Shorea javanica Koord. & Valeton
Silybum Marianum (L.) Gaertn.
Simarouba amara Aubl.
Costus
American pepper
Black salsify
Rye
Sesame
Damar
holy thistle
Simarouba
Sinapis alba L.
Sinapis arvensis L.
Siraitia grosvenorii (Swingle) C. Jeffrey ex A. M. Lu
& Zhi Y. Zhang
Sium sisarum L.
Smilax aristolochiifolia Mill
Smilax officinalis Kunth in HBK
Smilax spp.
Solanum melongena L.
Solanum oleracea L.
White mustard
Wild mustard
Lo han kuo
Solanum tuberosum L.
South American spp. of Copaifera L.
Spartium junceum L.
Spiraea ulmaria L.
Sterculia spp.
Potato
Copaiba
Genet
Meadosweet
Karaya gum
Chervi
Mexican sarsaparilla
Ecuador sarsaparilla
Sarsaparilla
Eggplant
American black nightshade
FEMA
3012 (savory, summer); 3013 (oil); 3014
(oleoresin);
3015 (Winter savory); 3016 (oil); 3017
(oleoresin);
2336 (root oil)
3018 (oil)
US FDA
CFR.21 §182.10; CFR.21 §182.20
COE425
CFR.21 §182.10; CFR.21 §182.20
COE426
CFR.21 §172.510
CFR.21 §182.20
COE53
COE427
COE428
COE2102
COE429
CFR.21 §182.10
COE
4820 (gum)
COE551; COE2103;
2761 (yellow mustard)
CFR.21 §172.510 (In alcoholic
beverages only)
CFR.21 §182.10; CFR.21 §182.20
COE431
COE432
4711 (concentrate)
3009 (extract)
3009 (extract)
3009 (extract)
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §172.510
2504 (absolute); 2505 (extract)
CFR.21 §172.510
CFR.21 §172.510
2605 (gum)
CFR.21 §184.1349
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COE433
COE2104A
COE2104
COE434
COE539; COE2105;
COE517; COE540;
COE2107;
COE2106
COE436
COE199A
COE437
19/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Stevia rebaudiana (Bertoni) Bertoni
English Name
Stevia rebaudiana
FEMA
4728 (Glucosyl steviol glycosides); 4771 (steviol
glycoside extract, Rebaudioside A 60%); 4772
(Steviol glycoside extract, rebaudioside A 80%);
4796 (steviol glycoside extract, rebaudioside C
30%); 4805 (steviol glycoside extract,
rebaudioside A 22%); 4806 (steviol glycoside
extract, rebaudioside C 22%); 4845 (Glucosylated
stevia extract); 4876 (Enzyme modified stevia,
stevioside 20%); 4895 (Rebaudioside M); 4909
(Glucosylated steviol glycosides, 70-80%); 4910
(Glucosylated steviol glycosides, 40%); 4911
(Stevia extract stevioside, 70%); 4931
(Glucosylated steviol glycosides, 90%)
Styrax benzoin Dryand.
Swertia chirata Buch.-Ham. ex Wall.
benzoin resin
Indian Chiretta
2133 (resin)
CFR.21 §172.510; CFR.21 §182.20
CFR.21 §172.510 (in alcoholic
beverages only)
Symphytum officinale L.
Syzygium aromaticum (L.) Merr. & L.M.Perry
Sage
Clove tree
CFR.21 §184.1257
Tagetes erecta L.
Tagetes glandulifera Schrank.
Tagetes spp.
Tamarindus indica L.
Tanacetum vulgare L.
Marigold
African marigold
Tagetes
Tamarind
Tansy
2322 (bud extract); 2323 (bud oil); 2324 (bud
oleoresin); 2325 (leaf oil); 2328 (stem oil);
3040 (oil)
3040 (oil)
3040 (oil);
Taraxacum officinale (L.) Weber ex F.H.Wigg.
Tasmannia lanceolata
Terminalia chebula Retz.
Tetraclinis articulata (Vahl) Mast.
Dandelion
Tasmania lanceolata
Myrobalan
Sandarac
Teucrium chamaedrys L.
Wall germander
Teucrium polium L.
Hulwort
Thaumatococcus daniellii (Benn.) Benth.
Theobroma cacao L.
Thuja occidentalis L.
Katemfe
Cocoa tree
Yellow cedar
2357 (fluid extract); 2358 (root extract solid)
4755 (extract)
US FDA
CFR.21 §172.510 (As oil only)
CFR.21 §172.510 (As oil only)
CFR.21 §172.510 (as oil only)
CFR.21 §182.20
CFR.21 §172.510 (In alcoholic
beverages only; finished alcoholic
beverage thujone free)
CFR.21 §182.20
COE
COE552; COE2108;
COE439; COE2109
COE440
COE441
COE188
COE494
COE443; COE2110
COE444
COE446
COE447
COE448
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §172.510 (in alcoholic
beverages only)
4831 (fruit extract)
2267 (leaf oil)
CFR.21 §182.20
CFR.21 §172.510 (finished food
thujone free)
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COE449
COE2110a
COE452
COE453
20/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Thymbra capitata (L.) Cav.
English Name
Origanum
Thymus serpyllum L.
Thymus vulgaris L.
Thyme
Thyme
Thymus zygis L.
Tilia spp.
Spanish Thyme
Linden
Tilia tomentosa Moench
Trachyspermum ammi (L.) Sprague
Trifolium pratense L.
Trigonella foenum-graecum L.
Silver linden
Ajowan
Clover tops
Fenugreek
Triticum aestivum L. emend. Fiori et Paol.
Tsuga and Picea spp.
Tsuga canadensis (L.) Carrière
Tuber magnatum Pico
Tuber melanosporum Vitt.
Turnera diffusa Willd.
Tussilago farfara L.
Ulmus fulva Michx.
Uncaria gambier Roxb.
Urtica dioica L.
Usnea barbata (L.) Wiggers
Vaccinium corymbosum L.
Vaccinium macrocarpum Aiton
Vaccinium myrtillus L.
Vaccinium oxycoccos L.
Wheat
Spruce
Canadian pine
piedmontese truffle
Truffle, French
Damiana
Coltsfoot
Slippery elm
Gambir
Common nettle
Treemoss
Highblush blueberry
Cranberry, large
Bilberry
Small cranberry
Vaccinium uliginosum L.
Vaccinium vitis-idaea L.
Valeriana officinalis L.
Vanilla spp.
Blueberry
Cowberry
Valerian
Vanilla
Verbascum thaspsus L.
Mullein
Verbena odorata
Verbena officinalis L.
Lemon verbena
Vervain
Veronica allionii Vill.
Alpine speedwell
FEMA
2827 (oregano, lippia ssp); 2828 (origanum oil)
US FDA
CFR.21 §172.510; CFR.21 §182.20;
CFR.21 §182.10
CFR.21 §182.10; CFR.21 §182.20
3063 (thyme); 3064 (red thyme oil); 3065 (white CFR.21 §182.10; CFR.21 §182.20
thyme redistilled oil);
CFR.21 §182.20
2647 (flowers)
CFR.21 §172.510 (in alcoholic
beverages only); CFR.21 §182.10;
CFR.21 §182.20
2326 (extract solid)
2484 (fenugreek); 2485 (extract); 2486
(oleoresin);
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §182.10; CFR.21 §182.20
3034 (spruce oil)
CFR.21 §172.510
CFR.21 §172.510
COE
COE454
COE455
COE456
COE457
COE458
COE2111
COE111
COE459
COE460
COE518; COE2112;
CFR.21 §172.510
CFR.21 §172.510
3099 (root extract); 3100 (root oil)
3104 (vanilla); 3105 (extract); 3106 (oleoresin)
CFR.21 §172.510
CFR.21 §182.10; CFR.21 §182.20
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §172.510 (in alcoholic
beverages only)
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COE461
COE544; COE2113;
COE545; COE2114;
COE462
COE463
COE464
COE465
COE468
COE2115
COE2116; COE4700;
COE470
COE469
COE529; COE571;
COE2117; COE4700;
COE471
COE472
COE473
COE474; COE2118
COE475
COE519; COE2119;
COE476
COE477
21/22
Global Reference List of Natural Complex Susbstances
22/01/2021
Latin Name
Veronica officinalis L.
Veronica
English Name
FEMA
Vetiveria zizanioides (L.) Nash
Vetiver
Viburnum prunifolium L.
Viola calcarata L.
Viola canina L.
Viola odorata L.
Viola tricolor L.
Black haw
Violet, Swiss
Dog's violet
Blue violet
Pansy
Vitis vinifera L.
Grape-vine
Viverra civetta Schreber
Civet
CFR.21 §182.20
CFR.21 §172.510 (In alcoholic
beverages only)
2331 (cognac oil, green); 2332 (cognac oil, white); CFR.21 §182.50
4045 (seed extract)
2319 (absolute)
CFR.21 §182.50
Yucca schidigera Roezl ex Ortgies
Yucca spp.
Zanthoxylum americanum Mill.
Zanthoxylum armatum DC.
Zanthoxylum bungeanum Maxim.
Zanthoxylum clava-herculis L.
Zea mays L.
Zingiber officinale Roscoe
Mohave Yucca
Yucca
Prickly ash
3121 (extract)
3120 (extract)
2110 (extract)
Japanese pepper
Pepperwood
Maize
Ginger
Butter
4754 (extract)
2110 (extract)
2335 (corn silk)
2520 (ginger); 2521 (extract); 2522 (oil); 2523
(oleoresin);
2171 (butter acids); 2172 (butter esters)
Butter starters distillate
Caramel color
Fusel oil
Pyroligneous acid
Arachidonic acid enriched oil
Valencene 80 extract
Nootkatone Complex
2173 (distillate)
2235 (caramel color)
2497 (oil, refined)
2968 (extract), 2967 (pyroligneous acid)
4679 (oil)
4838 (extract)
4941
2538 (bark extract)
US FDA
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §172.510 (in alcoholic
beverages only)
CFR.21 §172.510
CFR.21 §172.510
3110 (leaves absolute)
CFR.21 §172.510
CFR.21 §172.510
CFR.21 §182.20
COE
COE478
COE479
COE480
COE481
COE482
COE483
COE485
COE558; COE1006;
COE3006; COEVI (Civet)
COE487A
COE487
COE486
CFR.21 §182.20
CFR.21 §184.1262
CFR.21 §182.10; CFR.21 §182.20
COE2120
COE488
COE489
CFR.21 §172.515 (butter acids and
esters)
CFR.21 §184.1848
CFR.21 §182.1235
CFR.21 §172.515
CFR.21 §172.515
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22/22