Normal External Anatomy of the Left Eye Understanding Glaucoma Carunculum Glaucoma is a group of eye diseases that usually steals sight without warning and often without symptoms. It is a condition in which normal fluid pressure inside the eyes (intraocular pressure, or IOP) slowly raises when the aqueous humor which normally flows in and out of the eye cannot drain properly. Instead, the fluid collects and causes pressure damage to the optic nerve (a bundle of more than 1 million nerve fibers that connect the retina with the brain) with subsequent loss of vision. There are two major subtypes of glaucoma based on the eye’s anatomy: Open Angle and Narrow Angle. Lacrimal puncta Pupil Iris Sclera Open Angle Glaucoma Canal of Schlemm (drainage canal) Aqueous flow Narrow Angle Glaucoma Aqueous flow Canal of Schlemm (drainage canal) Iris Trabecular meshwork Iris Trabecular meshwork Lens Lens Ciliary process Ciliary process Open angle glaucoma is the most common form of glaucoma. The most likely site of disease is a malfunction of the trabecular meshwork which works more poorly over time. The site of obstruction is the trabecular meshwork that covers the entrance to the aqueous humor channels (Canal of Schlemm) which drain the fluid from the eye. Narrow angle glaucoma, is less common and different from open angle glaucoma. Eye pressure usually goes up very fast. This happens when the drainage canal gets blocked or covered. The angle between the iris and the cornea is not as wide and open as it should be. Outer edges of the iris bunch up over the drainage canal when the pupil enlarges too much or too quickly. Optic Disk Sagittal View of the Eye Canal of Schlemm (drainage canal) Normal Optic Nerve Advanced Glaucoma Optic Nerve Retina Cornea Vitreous humor Iris Pupil Lens Optic disk Anterior chamber (aqueous fluid) Ciliary process Vitreous body Inferior rectus muscle Optic nerve w w w. o p e n i n g s p r o g r a m . c o m ©2011 ©2011 Published in USA | pharma.wkhealth.com Images and text copyright ©2011 Wolters Kluwer Health | Lippincott Williams & Wilkins ©2011 Novartis AG 6/11 TRV11510MS-F