Uploaded by Stephanie Steele-Wren

Psychotropic Medications Tables

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ANTIDEPRESSANTS
SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIs)
DRUG
Sertraline (Zoloft)
Fluoxetine (Prozac)
Paroxetine (Paxil)
Citalopram (Celexa)
Escitalopram (Lexapro)
Fluvoxamine (Luvox)
NTMs
DRUG
Venlafaxine (Effexor)
NTMs
USED TO TREAT…
SIDE EFFECTS
Dry mouth, nausea, vomiting,
Depression, Anxiety,
diarrhea, constipation, loss of
Panic, Obsessive
Serotonin
appetite, decreased libido,
thoughts
Agonists
headache, tremor, sweating;
Serotonin Syndrome (jerking,
twitching, fever, delirium)
OCD
Serotonin Agonist
Heavier sedation, risk of Serotonin
~Trazodone (Desyrel)
Sleep, Depression
& Antagonist
syndrome
SSRIs are the front-line for depression: Fewer, less severe SEs than TCAs or MAOIs. Safer in overdose. Long half-life.
Related Antidepressants
Mirtazapine (Remeron)
Duloxetine (Cymbalta)
Buproprion (Wellbutrin,
Zyban)
USED TO TREAT…
Depression, Anxiety
SNRIs:
Serotonin and
Norepinephrine
Agonists
DNRI: Dopamine
and Serotonin
Agonists
Depression, Anxiety,
Insomnia
Depression, Chronic
pain
Depression (especially
refractory),
Smoking cessation
SIDE EFFECTS
Dry mouth, insomnia, headache,
HBP, sexual dysfunction
Sedation, dry mouth, constipation,
increased appetite (less nausea)
Nausea, dry mouth, constipation,
fatigue, decreased appetite,
sedation
Dry mouth, tremor, upset stomach,
anxiety, insomnia, decreased
appetite
TRICYCLICS (TCAs)
DRUG
Amitriptyline (Elavil)
Doxepin (Sinequan)
Nortriptyline (Pamelor)
Clomipramine (Anafranil)
Imipramine (Tofranil)
NTMs
USED TO TREAT…
Serotonin and NE
Agonists; ACH
Antagonist
Tx resistant depression;
chronic pain, anxiety
“gold standard” for OCD
Depression, Enuresis
SIDE EFFECTS
Sedation, anticholinergic effects
(dry mouth, constipation, urinary
retention, blurred vision),
headache, sexual dysfunction, GI Sx,
weight gain, confusion,
very easy and toxic in overdose!!
MONOAMINE OXIDASE INHIBITORS (MAOIs)
DRUG
Phenelzine (Nardil)
Tranycypromine
(Parnate)
Selegiline (EmSam)
NTMs
Dopamine,
Serotonin, NE
Agonists
Dopamine Agonist
USED TO TREAT…
Atypical Depressions,
Panic, Anxiety
Depression, Parkinson’s
SIDE EFFECTS
Blurred vision, sexual dysfunction,
increased appetite, sweating,
constipation, Hypertensive Crisis
with certain foods!!
MOOD STABILIZERS
DRUG
Lithium (Eskalith)
Carbamazepine (Tegretol)
Valproic Acid (Depakote)
Oxcarbazepine (Trileptal)
Topiramate (Topamax)
Lamotrigine (Lamictal)
NTMs
USED TO TREAT…
Unknown
mechanism
Front-line for Bipolar;
preventing suicide
Gaba
Agonists &
Sodium
Anticonvulsants used to treat
Bipolar, Seizures
Sodium
Depressive episodes of Bipolar
SIDE EFFECTS
Tremor, sedation, increased thirst
and urination, hypothyroidism,
Lithium toxicity (deadly)
Hepatic necrosis (liver failure),
agranulocytosis, anemia,
less risk of agranulocytosis
Reduced appetite, weight loss,
memory/concentration problems
Itchy rashes
Compiled by K. Laxton 2019
ANTI-ANXIETY AGENTS
ANXIOLYTICS (BenzodiAZEpines and Barbiturates)
DRUG
Triazolam (Halcyon)
Oxazepam (Serax)
Midazolam (Versed)
Clonazepam (Klonopin)
Alprazolam (Xanax)
Lorazepam (Ativan)
Temazepam (Restoril)
Diazepam (Valium)
Chlordiazepoxide
(Librium)
Buspirone (Buspar)
NTMs
USED TO TREAT…
SIDE EFFECTS
Panic Attacks
GABA Agonists;
increases GABA
to counteract
Glutamate
Anxiety, Panic Disorder,
Insomnia (esp. Restoril)
High sedation levels; very high risk
of abuse, addiction, and
dependence; rebound anxiety and
insomnia; withdrawal effects
Chronic Panic Disorder,
Alcohol Withdrawal
Serotonin and
Dopamine
General anxiety,
comorbid depression
Barbituates
Anxiety and panic
Much less addiction potential and
sedation, no withdrawal effects
Fallen out of favor due to high
overdose risk and withdrawal
ANTI-PSYCHOTICS
TYPICAL ANTIPSYCHOTICS (First Generation)
DRUG
Haloperidol (Haldol)
Chlorpromazine
(Thorazine)
Thioridazine (Mellaril)
Fluphenazine (Prolixin)
NTMs
Primarily
Dopamine
antagonists;
ACH and NE
antagonists
USED TO TREAT…
Psychosis (better for
positive sx than
negative sx),
Aggression,
Acute Mania
SIDE EFFECTS
High EPS Sx, Parkinsonian sx, dystonia,
akathisia, akinesia (“Thorazine
shuffle”), Anticholinergic effects (dry
mouth, constipation, blurred vision),
Tardive Dyskinesia, NMS!
ATYPICAL ANTIPSYCHOTICS (Newer)
DRUG
Risperidone (Risperdal)
Olanzapine (Zyprexa)
Quetiapine (Seroquel)
Aripiprazole (Abilify)
Ziprasidone (Geodon)
Clozapine (Clozaril)
NTMs
USED TO TREAT…
SIDE EFFECTS
Primarily
Dopamine
antagonists;
Serotonin and NE
Psychosis,
Aggression, Acute
Mania
Less EPS SE (but still present) and
much more metabolic SE: weight gain,
hyperglycemia, diabetes risk; sedation
and Anticholinergic effects
Dopamine
antagonist;
Serotonin
Single most effective
Rx for Psychosis
Above plus Agranulocytosis
(depleted white blood cells, fatal)
PSYCHOSTIMULANTS
DRUG
Methylphenidate
(Ritalin, Concerta)
Amphetamine-Dextroamphetamine
(Adderall, Dexadrine)
Lisdexamfetamine (Vyvanse)
Atomoxetine (Strattera)
NTMs
Dopamine,
Serotonin, and
NE agonists
NE agonist
TREAT…
SIDE EFFECTS
ADHD
Growth and appetite suppression,
insomnia, risk for recreational
use/abuse, increased sweating,
dizziness, heart palpitations
Same, but less growth suppression?
Compiled by K. Laxton 2019
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