Clinical
conditions
Herpes
Antihepatits
Drugs used in
the treatment
Idoxuridine,
acyclovir
Foscarnet
Interferons
Entecavir
SofosbuvirHepatitis C
Ribavirin
MOA
Forscarnet- inhibits the
pyrophosphate binding on viral
DNA polymerase
Interferon inducers turn on the
synthesis of intrinsic factor for
early innate immunity
IFN- activate immune cells such
as NK and macrophages.
Use
Ribavirin- RSV and HCV
Entecavir- HEP-B
Sofosbuvir- hep C
Sofosbuvir- inhibits RNA
polymerase used by hep C
Entecavir-blocks reverse
transcriptase
Antinfluenza
Amantidine,
rimanditine
Zanamivir
Osteltamivir
Ribavirin- M-RNA synthesis
inhibitor
Amatadine and ramatadineinhibit replication of influenza A
by blocking m2 proteininhibits
viral coating and penetration
Z&O- inhibits neuraminidase
NRTI
Zidovudine
NtRTs(nucleotide)
NNRTIsnevirapine
ProteaseRitonavr
Fusion
Z&O- for influenza A and
B
A&R- influenza A
Given systematically of topically- When used systematically may be administered
Orally or IV
CONTRA- hypersensitivity , congestive HF, seizures and Renal disease and lactation
Side effects- Gi disturbances, burning & stinging- when topically applied.
Ribavirin- anemia
Foscarnet- renal insufficiency, electrolyte imabalance
Drug interaction- Etravirine- other protease inhibitors
Many inducers or inhibitors of liver enzymes-influenced by Cp450 Inhibitorserythromycin and clarithromycin