Bryophytes -Dermatologic Conditions 1 Bryophytes- The Medicinal Uses of Mosses in Dermatologic Conditions Jennifer Archie ACHS Bryophytes -Dermatologic Conditions 2 Abstract The use of bryophyte as medicine has been common for hundreds, perhaps thousands of years. Bryophytes, or mosses, are the second largest group of plants with the characteristics of being nonvascular, and without true leaves and stems. This plant life holds as many as 28,000 species with three main types: mosses, hornworts, and liverworts. Historically, it has been used to pack wounds during World War I and create many folk remedies within indigenous peoples around the world. Research has shown that this seemingly mysterious and magical plant can be used to aid in a wide variety of skin disorders and ailments. The purpose of this study is to determine if the use of bryophytes as an alternative medicinal therapy improves the healing process in dermatologic issues. Bryophytes contain many compounds that are found distinctively useful in the treatment of skin infection, irritation and inflammation. These compounds include amino acids, fatty acids, polysaccharides, and phenylquinones. Studies indicate that bryophytes can be easily reproduced under scientific means to extract compounds to make medicine for dermatologic issues, making it a potential, and affordable treatment option for people who suffer from dermatologic disease, wounds or burns. Keywords: alternative, bryophytes, dermatologic, healing, medicinal, plants. Bryophytes -Dermatologic Conditions 3 Introduction Bryophytes are the family of plant life that includes the mosses, liverworts, and hornworts. It is the second largest group of plants that are non-vascular and have no true stems or leaves. Many people overlook this mysterious and seemingly magical organism as they walk along where it grows. Only flowering plants outnumber the bryophyte (Chandra, et al., 2015). It grows in abundance in forests, bogs, moors and many backyards. The medicinal use of mosses has been prevalent through history including the use of it as wound dressing during World War I. Sphangum moss was found to be absorbent and antiseptic for dressing soldiers wounds, when cotton and wool bandages ran short. Also, many cultures have historically used it as folk medicine. Cell structure of the bryophyte is unique in that it has a very dense quality and has the ability to have great uptake and retention of fluid (Varney &Barnett, 1987). This is why it has application in wound care. Results Mishra, Pandey, and Chandra (2014) took a closer look at bryophytes as therapeutics with some very interesting findings. The study stated that bryophytes are the second largest group of plants with the distinguishing characteristic of being without true leaves, stem, or vascularity. However, they do show alternation of generation like all other land plants that do possess those characteristics. Potential biotechnological and biopharmaceutical applications are possible due to Bryophytes -Dermatologic Conditions 4 secondary metabolites found in bryophytes. The authors found that in China, different species of bryophytes are available in pharmacies and are commonly used to treat tonsillitis, bronchitis, and many skin issues. Chandra et al. (2016) researched the use of environmentally safe pesticide, non-toxic to humans and animals, made from a member of the moss family. Their research also includes a section on Polytrichum pallidisetum that was found to impede the growth of melanoma. Tosun, Kupeli, Suntar, Ozenoglu, and Asakawa (2013) evaluated the bryophyte family used as anti-inflammatory and antinociceptive. It suggested that the sesquiterpenes found in the plant are partially responsible for the anti-inflammatory effect. The research of Singh et al. (2011) concentrated on the properties that bryophytes have regarding the healing of burns and the infections associated with burns. Impressively, the plant was found to be effective against Gram-positive bacteria, which often becomes immune to pharmaceutical antibiotics. Alam, Shrama, Rawat, and Verma (2015) focused on the many kinds of biological activity in compounds from bryophytes. Plagiochasma japonica and Marchantia tosama exhibit antitumor activity and muscle relaxation ability. Discussion The naturally present compounds in bryophytes used medicinally seem to have a wealth of healing properties. As a valuable source of bioactive compounds, bryophytes also appear to have lower topical side effects than using pharmaceutical-based medicines for dermatologic issues. Interestingly, the study conducted by Tosun, Akkol, Suntar, Ozengolu, & Asakawa (2013) indicates that the liverwort species has high sesquiterpenoids and reduce inflammation. This Bryophytes -Dermatologic Conditions 5 finding can lead to many advances in medicinal treatment of ailments such as the topical inflammation involved in psoriatic arthritis, for example. Another unique finding about the use of medicinal bryophytes addresses the problem of drug resistance. One major issue in medicine is fighting bacterial or fungal infection that becomes immune to commonly used medicines. Since the bryophyte is not saturating the pharmaceutical market, it may be an answer to this rising issue. The study by Mishra, Pandey, & Chandra (2014) brings about the point that mosses are very easily manipulated during laboratory production of biopharmaceuticals. This could potentially mean that with only water, necessary minerals, light and oxygen, many valuable medicines can be produced, quite easily and in abundance. The effect this would have on the cost to patients could be remarkable. Perhaps one of the most promising statements of the research (Chandra, et al., 2016) is that mosses can impede the growth of melanoma cancer cells. This area of medicinal moss research needs more study because of the severity, mortality and predominance of skin cancer. Conclusion Although the use of bryophytes to combat inflammation, wounds, irritation of skin, burns and many other dermatologic issues is historic in nature, dating back hundreds of years, perhaps thousands, the research needs to be on-going and progressive. It seemingly has a myriad of untapped uses and potential as medicine. The findings that it is easily reproduced in laboratory circumstances opens the theory of mass production, therefore decreasing costs to people suffering from dermatologic ailments. Bryophytes -Dermatologic Conditions 6 The fact that bryophytes have shown promise combating drug resistant bacteria and fungi is also a major point to further study. The growing reported incidence of drug resistance is a battle the pharmaceutical industry fights annually, but is growing in despite this effort. The need for more study is recommended. Bryophytes -Dermatologic Conditions 7 References Mishra, R., Pandey, V., & Chandra, R. (2014). Potential of Bryophytes as Therapeutics. International Journal of Pharmaceutical Science and Research. 5(9). 3584-3593. Chandra, S., Chandra, D., Barh, A., Pankaj, Pandey, R., Sharma, I. (2016). Bryophytes: Hoard of Remedies, An Ethno-medicinal Review. Journal of Traditional and Complementary Medicine. 7(1), 94-98. doi:10.1016/j.jtcme.2016.01.007 Tosun, A., Kupeli, E., Suntar, I., Ozenoglu, H., & Asakawa, Y. (2013). Phytochemical investigations and bioactivity evaluation of liverworts as a function of anti-inflammatory and antinociceptive properties in animal models. Pharmaceutical Biology, 51(8), 1008-1013. https://doi.org/10.3109.2013.774028 Singh, M., Singh, S., Nath, V., Sahu, V., & Singh-Rawat, A.K. (2011) Antibacterial activity of some bryophytes used for the treatment of burn infections. Pharmaceutical Biology, 49(5), 526530. https://doi.org/10.3109/13880209.2010.523007 Alam, A., Shrama, V., Rawat, K.K., & Verma, P.K. (2015). Bryophytes- The Ignored Medicinal Plants. Sikkim Manipal University Medical Journal, 2(1), 299-315. Varney, S. & Barnett, S. (1987). Sphangum moss and wound healing. Sage Journals. Doi: 10.1177/02692