Presented by: Sabir M. Uddin, MSN, BSN, RN * Bone marrow * Stem cells * White, Red, Platelet * Connective tissue * Transportation * Regulation * Protection * Plasma (55%) * Water, proteins, electrolytes, gases, nutrients * Blood Cells (45%) * Erythrocytes, leukocytes, thrombocytes * Vascular Response * Vasoconstriction * Platelet Plug Formation * Activated by intersitial collagen * Form clumps (aggregate) * Fibrin Clot * Coagulation factors * Fibrin * Lysis of Clot * Anticoagulation (antithrombins) * Plasminogen * Atrophy * Bone loss * More vulnerable * Decreased hemoglobin and iron * Membranes more fragile * WBC not affected * Past medical history * Anemia, bleeding disorders, blood diseases * Vitamins, herbal products, anticoagulants * Gastrectomy (vitamin B12), etc. * Family history, non-modifiable risk factors * Diet, weight * Blood in urine or stool * Fatigue, ADLs * Paresthesias, numbness, tingling, vision, hearing, taste, mental status * Menstrual cycle, HIV * Support for ADLs, fear * Medications * Surgery or other treatments * Health patterns * Nutrition/Metabolic * Elimination * Activity/Sleep * Cognitive-Perceptual * Sexuality/Reproductive * Coping-stress * Complete blood count (CBC) * Hemoglobin (Hgb): 11.7-16 (F) and 13.2-17.3 (M) * Hematocrit (Hct): 35%-47% (F) and 39%-50% (M) * White blood cells (WBC): less than 11,000 * Platelet Count: 150,000–400,000 * Deficiency of erythrocytes, quantity/quality of hemoglobin/hematocrit * Blood loss, impaired erythropoiesis, hemolysis * Decreased erythrocytes = potential hypoxia * S/S: palpitations, dyspnea, fatigue, pallor, pruritus (bile), jaundice (bilirubin), angina, cold, tacycardia, anorexia. * Complications: heart failure, MI, CVA * Treatment: blood, erythropoietin, volume replacement, oxygen, vitamins (i.e. B12, iron, niacin) * One of most common – 2%-5% of adults * Risks: young, women, poor diet * Causes: poor intake of iron, malabsorption, blood loss, hemolysis, bleeding. * S/S: pallor, glossitis, cheilitis, headache, paresthesia * Treatment: iron supplement http://umm.edu/health/medical/ency/vi deos/iron-deficiency-anemia * Vitamin B12 (cobalamin) deficiency * Caused by absence of intrinsic factor (IF) * Begins usually after age 40 * S/S: classic signs of hypoxia, sore, red, beefy, and shiny tongue (glossitis), anorexia, nausea, vomiting, weakness. * Treatment: Diet if lacking B12. If lacking IF, it does not matter how much B12 is ingested. Parenteral B12 or intranasal cyanocabolamin would be treatment of choice. * Complications: Without cobalamin administration, death may occur in 1 to 3 years.