1 What are requirements for pharmacists when they join in simple compounding? 4 Which of the following statements regarding ointment is true? 1 điểm 1 điểm A. Pharmacist must follow the direction of the manufacturer. A. For external use B. Pharmacist must calculate the proportion of components in the formulation. C. Pharmacist must have proper training. D. Choose A and C E. Choose B and C B. Is the semi solid dosage form C. Contains high proportion of water in formulation D. Choose A and B E. Choose A, B and C 2 Why must staffs follow recommendations for hand hygiene and garb attire? 5 Which excipient is used to keep ingredients from sticking to each other and the equipment? 1 điểm 1 điểm A. To prevent drugs from contamination. Flowing agent B. To protect staffs from cross contamination. Levigating agent C. To make staffs feel comfortable when compounding. Humectant D. Choose A and B E. Choose A, B and C 3 Which of the following statement regarding weighing equipment is true? A torsion balance has higher sensitivity than an electronic balance Both torsion balance and electronic balance can weigh small amounts accurately. A torsion balance is simpler to use than an electronic balance. A torsion balance can weigh small amounts accurately. An electronic balance can weigh small amounts accurately. Lubricant Glidant 6 Which equipment can be used to reduce the particle size of powder? 1 điểm Mold Spatula Tablet press Mortar and pestle Ointment slab 7 What should staff wear to protect their eyes during compounding? 1 điểm Eye cover Face mask Hair cover Eye shields Beard cover 8 Which of the following statements is true? 1 điểm Not all training must be documented. Equipment must be used with one specific drug to prevent cross contamination. Non-sterile compounding area has not to be separate from sterile compounding area. Washing facilities for cleaning hands in nonsterile area must minimally include a sink with hot and cold water, soap, and an airdryer. Equipment just needs to be calibrated for the first time when buying it. 9. If the amount of powder per dose is very small, it will be necessary to add a ____ (like lactose) to gain a minimum weighable quantity. 1 điểm Compounded drugs are manufactured in large quantity. Compounded drugs must not follow current Good Manufacturing Practices. Compounded drugs are be made for all patients in the hospital. Compounded drugs must be approved by FDA. Compounded drugs should be made in case active ingredients were not commercially available due to safety reasons. 11 This following passage describes which dosage form is made and which the method is used? "Plates sort the bodies to stand upright and hold them in place. The powder is put above the bodies on to a plastic sheet where a plastic spreader and comb is used to brush the powder into the bodies. The comb and spreader are used repeatedly until the powder is packed into the bodies. Then, the caps are put over the bodies. 2 điểm Powder are packed by automatic filling machine Sweetener Capsule are made by manual capsule-filling machine Flavoring agent Powder are packed by hand filling Diluent Coating Capsule are made by automatic capsulefilling machine Disintegrant Capsule are made by hand filling 10. Which of the following statements regarding compounded drugs is true? 12 . Which excipient should be added to a tablet for attractive appearance? 1 điểm 1 điểm Coloring agent Enteric coating Emollient Flavoring agent Humectant Wetting agent Wetting agent Disintegrant Hydrophylic solvent 13 . In which cases that compounded drug should be made? Adsorbent 2 điểm A drug is not commercially available for safety reasons. A patient is allergic to an active ingredient. A patient is allergic to a non-essential ingredient. A male with severe hand arthritis requires a combination of topical analgesics that are available in the market. A drug which has poor taste needs a flavor to make it more palatable. A child cannot swallow the tablet but there is no a liquid form of a drug in the market. 14 , What is the role of the emulsifier in emulsion formulation? 1 điểm A. Reduces the surface tension between oil and water B. Reduces the surface tension between insoluble solid particle and water C. Helps preparations more stable D. Choose A and C E. Choose B and C 16. Compete the following sentence: Ingredients are mixed into ointments on a (an) ___________, which is a flat board made of porcelain or glass. 1 điểm A. pill tile B. mortar C. ointment slab D. ointment mill E. Choose A and C F. Choose A, B and D 17 . Read the passage below and answer the question. “High-quality ingredients ensure the purity and safety of the formulations. The recommended compounding ingredients are listed in the USP National Formulary, or the list of Food Chemicals Codex substances. Preferably, the approved substances should be manufactured at an FDAregistered facility. If any substance comes from non-FDA registered facility, a Certificate of Analysis should be obtained that confirms the specification and quality requirements.” Which kind of ingredients meet the requirements for compounding? 15 . Which excipient is used to keep preparations moist? 2 điểm 1 điểm A. The ingredients are the list of Food Chemicals Codex substances. B. The ingredients are produced at an FDA and non-FDA registered facility. The wider the mouth of a conical graduate, the higher the measuring accuracy. C. The ingredients have a Certificate of Analysis. A graduated cylinder has the same diameter from the top to the bottom of the container. D. Choose A and B 20 . What are requirements for pharmacists when they join in moderate compounding? E. Choose A and C 18. Which of the following statements regarding measuring equipment is/are true? 2 điểm For measuring small volume, pharmacists should use graduated cylinder to have the most accurate measurement. A volumetric pipette can be used to measure different volumes. 1 điểm A. Pharmacist must follow the direction of the manufacturer. B. Pharmacist must calculate the proportion of components in the formulation. C. Pharmacist must have proper training. D. Choose A and C E. Choose B and C Pipettes can be used to deliver medication to the patients. A Mohr pipette is designed to deliver one fixed volume A volumetric pipette is designed to deliver one fixed volume. A volumetric pipette has one calibration mark. A Morh pipette can be used to measure different volumes. 19. Which of the following statement regarding a graduate is NOT true? 1 điểm A conical graduate has a wide mouth. A graduate is used to measure a volume. A conical graduate provides less accurate measurements than a graduated cylinder. Part 2: Reading test - Excipients in vaccines 22. Reading the passage in the paper, then answering the questions below. You should spend at least 30 minutes for this section. You can use your dictionary if needed. In the 2nd paragraph, why did the author mention about the use of aluminum in food industry? 2 điểm A. Aluminum is already in our body via food, so it is not necessary to add aluminum adjuvants in vaccines. B. He wants to bring up the conflict whether aluminum is beneficial or harmful among scientists. C. He wants to conclude that aluminum is absolutely safe because we have been using it for a long time. C. The amount of mercury in a standard dose of a thimerosal-containing vaccine is three times higher than an ounce can of tuna. D. A and C are correct. 26. What does the word “provisionally” in the last sentence refer to? 23. Which of the following statement is NOT correct when talking about gelatin? 1 điểm A. It helps the active ingredient more stable. B. It is a sweetener. C. It is made of pigs. D. Choose A and C 24. Which of the following pairs are NOT correct for classification of excipients? 1 điểm D. Polysorbate 80 – emulsifier C. Gelatin – stabilizer A. Thimerosal – emulsifier B. Thimerosal – preservative 25. According to the 3rd paragraph, which of the following statement is NOT correct when talking about thimerosal? 1 điểm D. Thimerosal is usually used as a preservative in vaccines that come in multidose vials. B. Thimerosal is a heavy metal therefore it is very harmful for healthy even though the amount in a vaccine is small. A. Thimerosal prevents a vaccine from being contaminated by microbiology. 1 điểm D. purposely B. absolutely A. contemporarily C. deliberately 27. What is the role of polysorbate 80 in vaccines? 1 điểm C. It is a solubilizing agent. B. It release a pain in the injected side. A. It triggers the immune system. D. It is an emulsifier. 28. What is the main issue that the author pointed out in the first paragraph? 1 điểm A. In general, we tend to ignore other components in the vaccines. B. The virus-related components in vaccines are the most important. D. Aluminum is a toxic agent and should not be included in vaccines. C. The immune system is overreacting to components in the vaccines, even with small amount. 29. According to the 2nd paragraph, which of the following statements is NOT true regarding the adjuvants in vaccines? 2 điểm C. Adjuvants themselves can trigger a strong immune response. A. Adjuvants can boost the vaccines’ effects. B. Active ingredients cannot work without the presence of adjuvants D. Aluminum can serve as an adjuvant in the body in the form of aluminum salts. 30. Which of the following statement best describes the safety profile of polysorbate 80? 1 điểm D. There is no information about the safety. A. It is harmful. C. The evidence is still conflicting. B. It is not harmful. 31. According to the 3rd paragraph, what is the concern of using thimerosal as an excipient in vaccine? 1 điểm B. Thimerosal can cause toxicity for patients. A. Thimerosal can cause autism in recent studies. C. Thimerosal can cause contamination for products. D. Thimerosal can cause fungal infection for products.
