6/17/2020 Effects of HIV: What happens to the body? What are the effects of HIV on the body? Medically reviewed by Timothy J. Legg, Ph.D., CRNP — Written by Silvana Montoya on March 15, 2017 Early effects Effects on the immune system Effects of medication When a person first contracts HIV, the virus will affect their body in several stages. If left untreated, HIV is likely to lead to AIDS. Due to medical advances over the last 30 years, the development of HIV can be significantly reduced or stalled. With lifelong medication, a person with HIV is usually able to lead a healthy life, and, in many cases, will never develop AIDS itself. ADVERTISEMENT Early effects ADVERTISEMENT https://www.medicalnewstoday.com/articles/316373#immune-system-effects 1/8 6/17/2020 Effects of HIV: What happens to the body? Flu-like symptoms may appear within the first 2-6 weeks of an HIV infection as the immune system fights the infection. The first signs of HIV usually appear after 2-6 weeks in the form of flu-like symptoms. This condition is known as seroconversion illness. Seroconversion is the stage when a person’s body is producing antibodies to HIV, which means that their immune system is fighting the infection. Flu-like symptoms that accompany seroconversion include: fever skin rash sore throat swollen glands joint or muscle pain These symptoms usually last for 1-2 weeks. Once the seroconversion period is over, a person may not experience any HIV symptoms for several years. Although people tend to feel well at this stage, it is important to remember that HIV is still active. As it continues to reproduce and infect ADVERTISEMENT new cells, HIV also damages a person’s immune system, which means it is unable to protect the body from illness. https://www.medicalnewstoday.com/articles/316373#immune-system-effects 2/8 6/17/2020 Effects of HIV: What happens to the body? Effects on the immune system HIV infects a cell by first Please accept our privacy terms attaching itself to, and merging with, the host T cells. T cells, also known to asimprove CD4 cells, areexperience a type of and white blood that MedicalNewsToday.com uses cookies your site to show youcell personalized advertising. To alearn more,part please readimmune our Privacy Policy. form crucial of the system. ACCEPT Once inside More information the host cells, HIV multiplies. The virus damages or destroys the cells before moving on to infect more cells. A CD4 count is an indication of the health of a person’s immune system. A healthy CD4 count is between 500 and 1,500. T cells or CD4 cells are a crucial part of the body’s immune system that HIV will infect and destroy. The CD4 count of a person with HIV who does not receive HIV treatment will reduce over time. Once the CD4 levels fall below 200, a person’s immune system will probably be damaged and the person will likely experience definitive signs and symptoms of illness. People who have HIV and are not receiving treatment put themselves at greater risk of developing symptoms, a condition known as symptomatic HIV. They are also more likely to pass on the virus to another person. Without treatment, a person is likely to develop AIDS because their immune system is no longer able to protect the body. At this stage, even ADVERTISEMENT the most minor infection becomes life-threatening. https://www.medicalnewstoday.com/articles/316373#immune-system-effects 3/8 6/17/2020 Effects of HIV: What happens to the body? Opportunistic infections and AIDS-defining illnesses A person with HIV may also become ill from opportunistic infections. They are called opportunistic because they take advantage of the weakened immune system. Opportunistic infections are usually caused by ordinary, harmless viruses, bacteria, and fungi, which only provoke disease when the immune system is compromised. Many of these infections are not life-threatening to a healthy person. To someone with HIV, however, they can be very serious and potentially fatal. An opportunistic infection is considered to be AIDS-defining when it spreads beyond the region or organ where it is typically found. Some of the more common opportunistic infections are: pneumonia tuberculosis certain cancers, such as Kaposi’s sarcoma thrush cytomegalovirus toxoplasmosis cryptococcal meningitis Coinfections Many people with HIV develop coinfections, diseases that can both have an effect on HIV and be affected by HIV. Tuberculosis and hepatitis are the most common HIV coinfections. ADVERTISEMENT ADVERTISEMENT https://www.medicalnewstoday.com/articles/316373#immune-system-effects 4/8 6/17/2020 Effects of HIV: What happens to the body? MEDICAL NEWS TODAY NEWSLETTER Stay in the know. Get our free daily newsletter Expect in-depth, science-backed toplines of our best stories every day. Tap in and keep your curiosity satisfied. Enter your email SIGN UP NOW Your privacy is important to us Effects of medication Side effects from ART drugs may include nausea, rashes, and headaches. ADVERTISEMENT https://www.medicalnewstoday.com/articles/316373#immune-system-effects 5/8 6/17/2020 Effects of HIV: What happens to the body? Although there is no cure for HIV, medical treatment is available that significantly reduces the amount of the virus in the body to the point where it may become undetectable in the blood. The amount of virus in a person’s body is known as the viral load. An undetectable viral load means that the person with HIV is not infectious and that the virus is not able to damage their immune system. HIV treatment is known as antiretroviral therapy (ART). It is recommended that everyone who is diagnosed with HIV begins treatment straight away, no matter what their CD4 count may be. Treatment for HIV is also referred to as combination therapy as people will usually take a combination of three different drugs at the same time. Combination therapy is used because HIV can adapt quickly and become resistant to a single type of ART. A “fixed dose combination” is when ART drugs have been combined into a single pill, which means that a person can take just 1 or 2 pills a day. It is very important that people take the drugs in the right way at the right time each day. People with HIV may experience side effects from their ART drugs. The most common side effects are: headache tiredness diarrhea nausea or vomiting rash high blood sugar levels high cholesterol When undergoing ART, a person needs to be aware that their medication may interact with other prescription medications as well as herbal remedies and recreational drugs. Other possible adverse effects include: ADVERTISEMENT anemia https://www.medicalnewstoday.com/articles/316373#immune-system-effects 6/8 6/17/2020 Effects of HIV: What happens to the body? hepatitis poor kidney function inflamed pancreas glucose intolerance A person taking ART drugs may find they experience metabolic effects, such as fat redistribution, hyperlipidemia, and insulin resistance. They may also develop conditions, such as osteopenia and osteoporosis, that will affect their bones. Despite these problems, there is evidence now of the long-term safety of ART, which has significantly improved the life expectancy of many people with HIV. Last medically reviewed on March 15, 2017 HIV and AIDS Immune System / Vaccines Infectious Diseases / Bacteria / Viruses 15 sources v Get our newsletter Health tips, wellness advice and more. Enter your email SUBSCRIBE Your privacy is important to us ADVERTISEMENT https://www.medicalnewstoday.com/articles/316373#immune-system-effects 7/8 6/17/2020 Effects of HIV: What happens to the body? v Popular News Editorial Articles All News Topics Knowledge Center Ad Policy Newsletters Share Our Content About Us Our Editorial Team Careers Contact Us Advertise With MNT Privacy Terms Privacy Settings © 2004-2020 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. All rights reserved. MNT is the registered trade mark of Healthline Media. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. ADVERTISEMENT https://www.medicalnewstoday.com/articles/316373#immune-system-effects 8/8
