Homœopathy and Hepatitis C - The basis for a successful practice Camilla Gold, Australia ABSTRACT: Figures released by the WHO in 2010, revealed that the Hepatitis C virus affects an estimated 170 – 180 million people worldwide. If these figures are compared to the estimated 34 million people living with HIV/AIDS (ibid, 2011), the question needs to be asked, how is it that HIV/AIDs has been given the dubious moniker of epidemic, whilst HCV has appeared to fall by the wayside becoming ‘the silent epidemic’? This article aims to place both diseases in their historical and cultural contexts, and in so doing, pose the question, what can we as homœopaths do to raise the profile of this devastating epidemic, and once again assert the viability of homœopathy as a legitimate and affordable treatment option in the 21st century? KEYWORDS: liver, Hepatitis C, HIV/AIDS, epidemic, Genus Epidemicus, Camilla Gold BHSc (Hom) recently graduated with a Bachelor of Health Science (Homœopathy) from Endeavour College of Natural Health. Having just set up practice in Cooroy, Queensland, she is now following her passion and is heading off to volunteer at the Maun Clinic in Botswana, where she will work with HIV/AIDs patients later this year. M: 0413 057 468 E: camilla@homworx.com.au “The physician who knows how to harmonize the liver knows how to treat the hundred diseases.” A whirlwind trip through the last 100 years will set the scene for this specific disease picture, back to a time before there were such things as HCV and its partner in crime, HIV/AIDs. Nothing happens in isolation; there can be no performance without stage and scenery, and of course the actors. From the Boer and the Boxer wars to the Russian Revolution and the lost generation of men in WWI, to the Great Depression, the wiping out of whole peoples in WWII, the bombings of Dresden, Hiroshima and Nagasaki, the first half of the last century reflects an image of a world with only one thing on its mind – self-destruction (syphilitic miasm perhaps?). The US Navy accepted its first submarines in time for WWI, Germans used chemical warfare for the first time, the Boer War introduced the first concentration camps; Hitler, Stalin, Mussolini and Franco led a war of attrition against humanity. This was the era of the Wall Street Crash and the Great Depression. The rules as the world knew them were changing as one by one existing boundaries were crossed. From a glass half-full perspective, the breaking down of these barriers facilitated the extraordinary proliferation of human invention: from a glass half-empty perspective, the pushing of boundaries left us like quicksilver, uncontained and uncontainable. The road that led from the early 1900s was one of great innovation, a time that was encapsulated by events such as the birth of psychoanalysis, the publishing of the theory of relativity, the discovery of the structure of the atom, penicillin, the aeroplane, the submarine, the opening of the Paris Metro, telegrams, the home electric refrigerator, breaking of the sound barrier, the first man on the moon, robot on mars, computers, women’s achieving the vote, and so on, and on and on. All extraordinary “breakthroughs”…however, there is a flip side to this story. The last century also was a time of complete devastation and destruction. By the 1950s however, there was a collective response to suppress the memories of the past and compensate by heralding in an era of excess, success defined through accumulation (Mind; avarice; full of desires) – a world driven by the concept that if you just keep busy (Mind; industrious; activity, amel.) and keep accumulating you can pretend that the past just didn’t happen (Mind; memory; weakness; happened, for what has). This is the golden era of television, the heyday of the pharmaceutical industry that unleashed tricyclic antidepressants along with the oral contraceptive pill on an unsuspecting world Zhou Xuehai ca.1895 This paper is an exploration of the whole being more than the sum of its parts; an attempt to contextualise disease homœopathically, historically, philosophically, culturally and, believe it or not, economically. Hepatitis C (HCV) has been selected as the central player in this story, as this is a relatively new disease that the author sees as representative of the human condition as it emerges out of the ashes of the twentieth century. A LITTLE BACKWARD GLANCE 16 Similia - The Australian Journal of Homœopathic Medicine June 2013—Volume 25 Number 1 (Mind; ailments; suppression). It was also the time that saw the ‘creation’ of Israel, the rise of Mao Tse Tung, the subsequent invasion of Tibet, McCarthyism, ‘reds under the beds’ and persecution of the other (Mind; fear; persecution, of; Mind; suspicion; Mind; sadness; persecutions of others, by; Mind; fear; people, of, anthropophobia; suspiciousness, with) and the first known case of HIV/AIDs. On to the 60s, where the children borne to the good folk of the 50s, just knew that something wasn’t right – think any David Lynch movie – what really goes on behind those picket fences? (Mind; suspiciousness, mistrustfulness) These children grew up to question the structures that bound them (Mind; confusion, identity) – they questioned authority including religion, government and family (Mind; nihilistic attitude); they protested against inequality, wars and violence (Mind; ailments from; anger, suppressed; Mind; indignation). These were ‘the children of the revolution’ of whom Marc Bolan was singing, an anthem that sums up a generation of middle-class kids that felt that the only way to prevent ‘Mind, dwells on past disagreeable occurrences’ was to acknowledge such events and try to enact change to ensure that they didn’t happen again. However, these children of the revolution were not entirely successful in their mission, for whilst they did voice their disagreement, making great inroads into issues like gender, racial equality and conscription, many of the boundaries that were broken down were done so with no forethought as to what should replace them. Like the hallucinogenic drugs that became commonly available during this era, the world had moved from a period of frantic and desperate destruction into one of existentialist dilemma – I am all, I am nothing – as the lullaby says ‘when the bough breaks, the baby will fall’ (but at least that baby had a cradle!) (Mind; confusion; identity; Mind; fear; mind; delusion; existence; without form in vast space). Moving forward through the 1970s, 80s and 90s, the picture becomes clear. By 1981, the first patient was admitted with identifiable HIV/AIDS; by 1989, the Hepatitis C virus had also been classified and the dawn of disease without boundaries had well and truly broken. THE LIVER: In physical terms, the liver is the largest organ in the body (excluding the skin) and aids digestion by producing enzymes Similia - The Australian Journal of Homœopathic Medicine June 2013—Volume 25 Number 1 that convert nutrients from food to be absorbed by the body: it stores fats, sugars, iron and vitamins, manufactures bloodclotting proteins, assists in regulating sugar metabolism, and eliminates and chemically alters substances that are toxic to the body (Tortora & Derrickson, 2009). Put simply, the liver plays an essential part in almost all of our body’s functions. To put the role of the liver, both as a functional process and as an organ, into a homœopathic context, the multi-faceted liver can thus be viewed as one of the body’s principal organs that works in tandem with the Vital Force. In other words, when Samuel Hahnemann describes the action of the Vital Force “in the healthy human state, (as) the spirit-like life force (autocracy) that enlivens the living organism as dynamis, governs without restriction and keeps all parts of the organism in admirable, harmonious, vital operation, as regards both feelings and functions, so that our in dwelling, rational spirit can freely avail itself of this living, healthy instrument for the higher purposes of our existence.” (§9, 1996, p.65), the liver and its functions play a primary role in facilitating the important work of the Vital Force. Just as we are conduits for healing in the consulting room, the liver, along with the heart and the brain, form the conduit through which the Vital Force must pass, in order to animate the living form. WHAT IS HEPATITIS C (HCV)? The term ‘hepatitis’ simply means inflammation of the liver, but is more commonly used in reference to one of seven different viruses whose primary target is the liver. In the case of HCV however, it can also progress to other organs (di Lorenzo et al, 2011; Farquar & McKeating, 2008). References to hepatitis, in the form of jaundice, have been recorded as far back as Hippocrates, resurfacing in the eighth century and again in the seventeenth, eighteenth and nineteenth centuries, generally appearing hand in hand with bloody wars (hepatitis central, 2012). First classified in 1989, Hepatitis C is an opportunistic, contagious disease caused by a virus that infects the liver. Although it wasn’t identified until 1989, retrospectively reported and diagnosed cases go back at least to 1971 in Australia (refer Appendix A – HCV timeline). To date there are six genotypes and 50+ sub-types – genotype 1 has been the most resistant to available treatment (Chen & Morgan, 2006). Currently an estimated 170-180 million people are affected worldwide (WHO, 2010). Contrast the above with approximately 34 million people living with HIV/AIDS (WHO, 2011). Put into local terms, in Australia, the number of people infected with HIVAIDs in 2010 was 1,043, while the number of people testing positive for HCV was 7,286 (ABS, 2012). MODE OF TRANSMISSION: HCV is transferred via blood-to-blood contact. Most common forms of transmission: blood transfusions prior to 1992, sharing needles, needle prick incidents, tattooing and high risk sexual activity e.g. sex industry (Peters, 2004). Other forms of transmission include: social use of cocaine, solid organ transplant with an infected organ, haemodialysis patients, people with HIV, being born to an infected mother, household infection by living with someone infected with HCV (Chen & Morgan, 2006). PATHOPHYSIOLOGY It is an RNA virus that uses the liver cell’s own genetic mechanisms to make innumerable copies of itself, so that it can go on to infect a maximum number of cells. Dependent on prolific self-replication and inhibited T-cell immune response. Known as the ‘silent killer’, incubation period ranges from two weeks to six months (Merck, 2003). Two main types: Acute and Chronic. Failure of the symptoms to clear after six months sees diagnosis move from Acute to Chronic Hepatitis C. Factors influencing the course of chronic HCV – age (35+ typically more rapid progression); gender (women have greater propensity to spontaneously clear the virus, particularly if younger than 50); co-infection with HBV or HIV/AIDs; fatty liver– viral load and genotype do not alter the course of the disease, although genotype 1 is more resistant to conventional treatment (Baker et al, 2002). 17 Prognosis: +85% of patients with chronic hepatitis C will go on to develop cirrhosis of the liver, liver cancer or complete liver failure. SYMPTOMS: ACUTE • non-specific ‘flu-like symptoms • weakness • aching joints • overwhelming tiredness • headaches • nausea • loss of appetite • itching of the skin • jaundice (very rarely) • dark urine • abdominal pain and • grey coloured stool (hepatitis central 2012) Sufferers of acute HCV often have such non-specific or mild symptoms they may go undiagnosed. Consequently they are unwitting carriers of the disease, increasing the reach of its already ravenous desire to replicate and infect. SYMPTOMS: CHRONIC • portal hypertension resulting from compromised liver circulation and therefore function • ascites • oesophageal varices and other bleeding diatheses • bone pain • diabetes mellitus steatorrhœa (fatty stools) • aortic aneurysm • cardiovascular disease • liver cancer and complete liver failure (Merck Manual, 2006) Clinical tip: A patient that fits this criteria but is not showing any symptoms is likely to both have had the infection for a considerable length of time and be an active carrier (hepatitis-central, 2012). DIAGNOSIS • Blood screening test using enzyme immune-assays (EIAs) to test for positive reaction for HCV antibody. 18 • Confirmation using recombinant immunoblot assay (RIBA), to remove possibility of false positive. • Hepatitis C RNA assays to measure the viral load - i.e. at a molecular level – also used to assess treatment response – as it is testing for the presence of the virus and not the antibodies, can obtain results from recent (two to three weeks’) exposure. • A single negative test is not accurate, as the virus can both appear intermittently in the blood or at very low levels. • Genetic testing to assess genotype. • Albumin level assessment. • Liver function tests. • Prothrombin time (i.e. blood clotting factor). • Liver biopsy – though this is more relevant in terms of on-going monitoring (Medline, 2012). Although these preceding facts about HCV are important, in that they describe the physical parameters of the disease, they tell us very little about the experience of the disease. In other words, this is not the symptom totality of the disease; it serves more as a summary of its mode of action and likely progression. HOMEOPATHY AND HCV Current Status There are three principle areas for your consideration regarding the current role of homœopathy in the treatment of HCV. Firstly, although HCV was identified in 1989 and there are, currently identified, approximately 350 homœopathic medicines with known curable actions on diseases of the liver (Gardener, 2011), the world’s first large-scale homœopathic trial was only announced in July 2012 (Shah, 2012). Prior to this announcement, research into the efficacy of homœopathic CONVENTIONAL TREATMENT: treatment of this ‘silent epidemic’ has • Interferon, Pegylated Interferon, been sadly thin on the ground. However, Ribavirin, Amantadine – virus of the research that has been conducted suppressors. in this area, findings have indicated that the positive effect of both Carcinosin 200C • Protease Inhibitors – never used on and Chelidonium 200C in hepatotoxic rats their own but in conjunction with (not terribly homœopathic), may serve other drugs. as a basis for validating the inclusion • Success rate: approximately 50% of homœopathic medicines as a part (medicinenet, 2012). of an overall treatment plan (Banerjee et al, 2010). Interestingly, the results of Adverse reactions: extreme nausea, this study also revealed that these two anxiety, depression, neutropenia, medicines given in combination had anaemia, insomnia, muscle pain and a greater prophylactic and curative weakness, restless legs syndrome, effect than when administered as diabetes mellitus, psychosis, suicide, single doses (ibid). Similar results were pancreatitis, along with cardiac and found in a study of the plant extract pulmonary symptoms (Gardner, 2012). when administered in tincture form to New treatments are designed to target the hepatocarcinogenic mice (Biswas et al, host cells, instead of the virus, eradicating 2008). the need to incorporate interferon in Epidemics the treatment protocol (O’Brien, 2012). Lauded as radical breakthroughs with Secondly, HCV needs to be placed indications of higher success rates, the within the context of the homœopathic literature on these refers to the new definition of an epidemic, whereby treatment being used in conjunction one disease is seen to affect an entire with other HCV medications “as part of group of people. Since Hahnemann’s an oral, anti-Hep C cocktail” (ibid). This successful treatment of a scarlet fever literature reads more like a marketing epidemic in Cologne in 1799 the efficacy proposal, referring to their findings of homœopathic treatment of epidemic as being sure “to attract the attention disease has been well documented (van of several players in the field” (ibid). der Zee, 2011). Indeed, comparative A similar release, refers to “…several figures in relation to the success rate of companies racing to develop hepatitis C homœopathic treatment versus allopathic pills…with the market for new therapies treatment of patients during the great forecast to reach $20 billion by 2020” epidemics of the nineteenth and twentieth (Flinn & Armstrong, 2012). centuries, not only support the efficacy of Similia - The Australian Journal of Homœopathic Medicine June 2013—Volume 25 Number 1 homœopathic over allopathic treatment during epidemics, but also reveal that the mortality rates of those treated allopathically was significantly greater (Malik, 2013). Based on these figures, the evidence is clear - homœopathic treatment of epidemic disease forms the basis of a viable (and affordable), treatment protocol. disease in the spotlight, whilst leaving the other to languidly proliferate, slow and secretive? 6. HCV is a highly individualised illness, therefore fits perfectly into the homeopathic paradigm; 7. The medical profession whilst racing to find a “cure” and despite claims that the drug cocktails are the answer, also acknowledges that their existing treatment options have only a 50% success rate and too often, the adverse effects of these treatments cause further irreparable damage; 8. As a result, HCV is one of the rare conditions, in which patients are actively encouraged to pursue alternative therapies, so long as they speak to their primary health carer (Hepatitis Central, 2013); 9. Therefore as a profession, we as homœopaths are perfectly placed to raise the profile of HCV, the silent epidemic, and once again take our place as the treatment of choice on the world stage of primary healthcare. CONCLUSION Returning to the beginning of the paper, you were taken on a guided tour through the world that spawned HIV/AIDs, and hopefully the point is clear, that this is also the stage upon which HCV plies its Genus Epidemicus trade. By nature this disease is insidious Within the homœopathic paradigm, and deceptive. It progresses slowly, epidemic disease is viewed as a collective taking up to twenty years to manifest response to perceived stress, be that in all its true hideous glory. It hides stress a reaction to war, natural disaster, in the dark, in the shadows; it evades or collective shock or grief etc. (ibid). detection in clinical tests. Until Lifeforce In other words, the effects of epidemic (Shah, 2012) announced their intention to disease transcend the level of the conduct an in-depth study of the efficacy personal, minimising the importance of of homœopathic treatment of HCV individual traits and history. In this way, in 2012, it seems that our community the epidemic becomes the person with has been complicit in the proliferation the disease, and “…the character of the of its deception. If, according to the epidemic disease is discovered according homeopathic paradigm, two dis-similar to the symptom complex common to all diseases cannot co-exist in the human the patients (i.e. the genus epidemicus), body, is it possible that this rate of cothat will point to the homœopathically infection is an indication that HIV/AIDs fitting (specific) medicine for the totality and HCV together form one diseased of the cases…” (O’Reilly, 1996, §241 response to the events of the last century pg.214). i.e. they represent both the acute and the Within the genus epidemicus framework, chronic disease state of the 20th century? both disease-specific symptoms, in However, returning to the subtitle of conjunction with changed symptoms this paper – HCV, the basis for a successful within the patient form the basis of practice – your attention is drawn to the treatment protocol. By gathering all following: symptoms of the disease in this manner, 1. The liver is one of the primary organs the medicine or medicines that are the that forms the conduit through best match for this symptom totality, which the vital force is able to can be safely administered to all people transit through the body; as such, suffering with the disease. Along with homeostasis is contingent on a fully the use of nosodes, this is the theory functioning liver; that forms the basis of the homœopathic treatment response to epidemics such 2. Subsequently, understanding the as HIV/Aids, Tuberculosis, Swine Flu, functions of the liver, forms the basis Dengue Fever, to name a few (Golden, to understanding much of disease; 2012; van der Zee, 2011; Hahnemann, 3. Homœopathy has a proven track 1996). record in the successful treatment of The final area for your consideration, infectious diseases, well documented and forming part of the impetus for during the great epidemics of the this article is the perception that if the nineteenth and twentieth centuries; number of people currently infected 4. Although the world is currently with HCV almost triples that of those experiencing an HCV epidemic, there suffering with HIV/AIDs, then why is currently no successful unified has the latter so quickly been given the treatment protocol, homœopathic or mantle of not just epidemic, but in the otherwise; homœopathic world, of miasm as well? This is indeed a serious question and 5. The current rate of co-infection with not raised to make comparisons between HIV is increasing (four million), degrees of suffering. What is it about with HCV being attributed to the these two diseases, both manifestations final cause of death in most cases of the twentieth century, that puts one Similia - The Australian Journal of Homœopathic Medicine June 2013—Volume 25 Number 1 (Operskalski & Kovacs, 2011; Peters, 2004); 10. Homœopathy and Hepatitis C – the basis for a successful practice. Finally, this quote is taken from the website of the Hepatitis and Aids Research Trust: “The only thing necessary for these diseases to triumph is for good people and governments to do nothing.” References Australian Bureau of Statistics (ABS) 2012 ‘Year Book Australia, 2012’ viewed 2 October 2012 http://www.abs.gov.au/ausstats/abs@. nsf/Lookup/by%20Subject/1301.0~Main%20 Features~Communicable%20diseases~232# Baker T, Cohen M, Dietrich R, Everson GT, Flesner S, Gish RG, et al, QC 2002 Hepatitis C: Choices 2nd edn. 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O’Reilly, W, Birdcage Books, Palo Alto 20 Farquhar, MJ & McKeating, JA 2008 ‘Primary hepatocytes as targets for Hepatitis C virus replication’ Journal of Viral Hepatitis vol.15 no.12 viewed217.10.12 http://www.ncbi.nim. nih.gov/pmc/articles/PMC3083516/ Golden, I 2012 The Complete Practitioner’s Manual of Homœoprophylaxis: A Practical Handbook of Homeopathic Immunisation, Isaac Golden Publications, Gisborne, Australia Golden-Mason, L & Rosen, HR 2006 ‘Natural killer cells: primary target for hepatitis C virus immune evasion strategies?’ Liver Transplant vol.12 no.3 pp.363-72 viewed217.10.12 http:// www.ncvi.nim.nih.gov/pubmed/16498647 Hepatitis-central.com 2013 ‘Hepatitis C: Are there alternative therapies for the treatment of Hepatitis C?’ viewed217.10.12 http://www. hepatitis-central.com/hepatitis-c/hepatitis-calternative-therapies.html King, J 2000 ‘We’ve got Hep C and we’re mad as hell. 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John Wiley & Sons, Inc, Hoboken Veazey, RS, Marx, PA, Lackner, AA 2001 ‘The mucosal immune system: primary target for HIV infection and AIDs’ Trends Immunological vol.22 no.11 pp.626-33 viewed 16.10.12 http:// www.ncbi.nim.nih.gov/pubmed/11698224 Van der Zee, H, 2011 ‘Healing humanity with homeopathy: homeopathy for epidemics, collective trauma and endemic disease’ California Homeopath vol.14 no.1 Similia - The Australian Journal of Homœopathic Medicine June 2013—Volume 25 Number 1