REFERENCES 1. Cogen AL, Nizet V, Gallo RL (2008) Skin microbiota: a source of disease or defence? Br J Dermatol 158: 442-455. 2. Grice EA, Segre JA (2011) The skin microbiome. 3. Shendure J, Ji H. Next-generation DNA sequencing. Nat. Biotechnol. 2008;26:1135–1145. [PubMed] [Google Scholar] 4. Whitman WB, Coleman DC, Wiebe WJ. Prokaryotes: the unseen majority. Proc. Natl. Acad. Sci. USA. 1998;95:6578–6583. [PMC free article] [PubMed] [Google Scholar] 5. Grice EA, Segre JA. The skin microbiome. Nat. Rev. Microbiol. 2011;9(4):244–253. [PMC free article] [PubMed] [Google Scholar] 6. Belkaid Y, Tamoutounour S. The influence of skin microorganisms on cutaneous immunity. Nat. Rev. Immunol. 2016;16(6):353– 366. [PubMed] [Google Scholar] 7. Zhang, H., J. K. DiBaise, A. Zuccolo, D. Kudrna, M. Braidotti, Y. Yeisoo, P. Parameswaran, M. D. Crowell, R. Wing, B. E. Rittmann, and R. Krajmalnik-Brown. 2009. Human gut microbiota in obesity and after gastric bypass. Proc. Natl. Acad. Sci. U. S. A. 106:2365-2370. Abstract/FREE Full TextGoogle Scholar 8. Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214 (2012). 9. Grice EA, Segre JA. 2011. The skin microbiome. Nat. Rev. Microbiol. 9:244– 253. doi:10.1038/nrmicro2537. CrossRefPubMedGoogle Scholar 10. K. Becker, C. Heilmann, G. PetersCoagulase-negative staphylococci Clin. Microbiol. Rev., 27 (2014), pp. 870-926 11. Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Murray PR, Green ED, Turner ML, Segre JA. 2009. Topographical and temporal diversity of the human skin microbiome. Science 324:1190– 1192. http://dx.doi.org/10.1126/science.1171700. 12. Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. 2009. Bacterial community variation in human body habitats across space and time. Science 326:1694–1697. http://dx.doi.org/10.1126/science.1177486. 13. Wos-Oxley ML, Plumeier I, von Eiff C, Taudien S, Platzer M, VilchezVargas R, Becker K, Pieper DH. 2010. A poke into the diversity and associations within human anterior nare microbial communities. ISME J. 4:839–851. http://dx.doi.org/10.1038/ismej.2010.15. 14. Graham JE, Moore JE, Jiru X, Moore JE, Goodall EA, Dooley JS, Hayes VE, Dartt DA, Downes CS, Moore TC. 2007. Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes. Invest. Ophthalmol. Vis. Sci. 48:5616–5623. http://dx.doi.org /10.1167/iovs.07-0588. 15. Willcox MD. 2013. Characterization of the normal microbiota of the ocular surface. Exp. Eye Res. 117:99 –105. http://dx.doi.org/10.1016/j .exer.2013.06.003. 16. Kong HH, Segre JA. 2012. Skin microbiome: looking back to move forward. J. Invest. Dermatol. 132:933–939. http://dx.doi.org/10.1038/jid .2011.417. 17. Iwase T, Uehara Y, Shinji H, Tajima A, Seo H, Takada K, Agata T, Mizunoe Y. 2010. Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization. Nature 465:346–349. http://dx.doi.org/10.1038/nature09074. 18. Nodake Y, et al. Pilot study on novel skin care method by augmentation with Staphylococcus epidermidis, an autologous skin microbe – a blinded randomized clinical trial. J Dermatol Sci. 2015. https://doi.org/10.1016/j.jdermsci.2015.05.001. 19. Sonnenburg, J. L. Microbiome engineering. Nature 518, S10–S10 (2015). 20. E. Rubinchik, D. Dugourd, T. Algara, C. Pasetka, H. D. Friedland, Antimicrobial and antifungal activities of a novel cationic antimicrobial peptide, omiganan, in experimental skin colonisation models. Int. J. Antimicrob. Agents 34, 457–461 (2009). 21. Lomholt HB, Kilian M. Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne. PLoS One. 2010;5:e12277. doi: 10.1371/journal.pone.0012277. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 22. A. Tanca, A. Palomba, M. Deligios, T. Cubeddu, C. Fraumene, G. Biosa, D. Pagnozzi, M. F. Addis, S. Uzzau, Evaluating the impact of different sequence databases on metaproteome analysis: Insights from a lab-assembled microbial mixture. PLOS ONE 8,e82981 (2013). 23. Segre, J. A. (2006). Epidermal barrier formation and recovery in skin disorders. J. Clin. Invest. 116, 1150–1158. doi: 10.1172/JCI28521 24. Grice, E. A., and Segre, J. A. (2011). The skin microbiome. Nat. Rev. Microbiol. 9, 244–253. doi: 10.1038/nrmicro2537 25. Sanford, J. A., and Gallo, R. L. (2013). Functions of the skin microbiota in health and disease. 10.1016/j.smim.2013.09.005 Semin. Immunol. 25, 370–377. doi: 26. Scheimann, L. G., Knox, G., Sher, D., and Rothman, S. (1960). The role of bacteria in the formation of free fatty acids on the human skin surface. J. Invest. Dermatol. 34, 171–174. doi: 10.1038/jid.1960.23 27. Schommer, N. N., and Gallo, R. L. (2013). Structure and function of the human skin microbiome. Trends Microbiol. 21, 660–668. doi: 10.1016/j.tim.2013.10.001 28. Nodake, Y., Matsumoto, S., Miura, R., Honda, H., Ishibashi, G., Matsumoto, S., et al. (2015). Pilot study on novel skin care method by augmentation with Staphylococcus epidermidis, an autologous skin microbe-a blinded randomized clinical trial. J. Dermatol. Sci. 79, 119–126. doi: 10.1016/j.jdermsci.2015.05.001 29. Belkaid, Y., and Segre, J. A. (2014). Dialogue between skin microbiota and immunity. Science 346, 954–959. doi: 10.1126/science.1260144 30. Schleifer KH, Kloos WE. 1975. Isolation and characterization of staphylococci from human skin. I. Amended descriptions of Staphylococcus epidermidis and Staphylococcus saprophyticus and descriptions of three new species: Staphylococcus cohnii, Staphylococcus haemolyticus, and Staphylococcus xylosus. Int. J. Syst. Bacteriol. 25:50–61. 31. Kloos WE, Musselwhite MS. 1975. Distribution and persistence of Staphylococcus and Micrococcus species and other aerobic bacteria on human skin. Appl. Microbiol. 30:381–385. 32. Kloos WE, Schleifer KH. 1975. Isolation and characterization of staphylococci from human skin. II. Description of four new species: Staphylococcus warneri, Staphylococcus capitis, Staphylococcus hominis, and Staphylococcus simulans. Int. J. Syst. Bacteriol. 25:62–79. 33. Kloos WE, Schleifer KH. 1983. Staphylococcus auricularis sp. nov.: an inhabitant of the human external ear. Int. J. Syst. Bacteriol. 33:9–14. http://dx.doi.org/10.1099/00207713-33-1-9. 34. Bieber L, Kahlmeter G. 2010. Staphylococcus lugdunensis in several niches of the normal skin flora. Clin. Microbiol. Infect. 16:385–388. http://dx.doi.org/10.1111/j.1469-0691.2009.02813.x. 35. van der Mee-Marquet N, Achard A, Mereghetti L, Danton A, Minier M, Quentin R. 2003. Staphylococcus lugdunensis infections: high frequency of inguinal area carriage. J. Clin. Microbiol. 41:1404–1409. http://dx.doi.org/10.1128/JCM.41.4.1404-1409.2003. 36. Bieber L, Kahlmeter G. 2010. Staphylococcus lugdunensis in several niches of the normal skin flora. Clin. Microbiol. Infect. 16:385–388. http://dx.doi.org/10.1111/j.1469-0691.2009.02813.x. 37. Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214 (2012). 38. Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011;9:244–53. 39. Kong HH, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012;22:850–9. 40. Lomholt HB, Kilian M. Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne. PLoS One. 2010;5:e12277. 41. Kobayashi T, et al. Dysbiosis and Staphyloccus aureus colonization drives inflammation in atopic dermatitis. Immunity. 2015;42:756–66. 42. Chng KR, et al. Whole metagenome profiling reveals skin microbiomedependent susceptibility to atopic dermatitis flare. Nat Microbiol. 2016;1:16106. 43. Myles IA, et al. Transplantation of human skin microbiota in models of atopic dermatitis. JCI Insight. 2016;1. 44. Alekseyenko AV, et al. Community differentiation of the cutaneous microbiota in psoriasis. Microbiome. 2013;1:31. 45. Wang L, et al. Characterization of the major bacterial-fungal populations colonizing dandruff scalps in Shanghai, China, shows microbial disequilibrium. Exp Dermatol. 2015;24:398–400. 46. Clavaud C, et al. Dandruff is associated with disequilibrium in the proportion of the major bacterial and fungal populations colonizing the scalp. PLoS One. 2013;8:e58203. 47. Fitz-Gibbon S, et al. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol. 2013;133:2152–60. 48. Lomholt, H. B., Scholz, C. F. P., Brüggemann, H., Tettelin, H. & Kilian, M. A comparative study of Cutibacterium (Propionibacterium) acnes clones from acne patients and healthy controls. Anaerobe 47, 57–63 (2017). 49. Barnard E, Shi B, Kang D, Craft N, Li H. The balance of metagenomic elements shapes the skin microbiome in acne and health. Sci Rep. 2016;6:39491. 50. Allhorn M, Arve S, Brüggemann H, Lood R. A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes. Nat Publ Gr. 2016. https://doi.org/10.1038/srep36412. 51. van Nood E, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med. 2013;368:407–15. 52. Grice EA, Kong HH, Conlan S (2009). "Topographical and Temporal Diversity of the Human Skin Microbiome". Science. 324 (5931): 1190– 1192. Bibcode:2009Sci...324.1190G. doi:10.1126/science.1171700. PMC 280 5064. PMID 19478181. 53. Pappas S. (2009). Your Body Is a Wonderland ... of Bacteria. ScienceNOW Daily News 54. Cogen AL, Nizet V, Gallo RL (2008). "Skin microbiota: a source of disease or defence?". Br J Dermatol. 158 (3): 442–55. doi:10.1111/j.1365 2133.2008.08437.x. PMC 2746716. PMID 18275522. 55. Grice EA, Kong HH, Renaud G, Young AC, Bouffard GG, Blakesley RW, Wolfsberg TG, Turner ML, Segre JA (2008). "A diversity profile of the human skin microbiota". Genome Res. 18 (7): 1043– 50. doi:10.1101/gr.075549.107. PMC 2493393. PMID 18502944. 56. Costello EK, et al. Bacterial community variation in human body habitats across space and time. Science. 2009; 326:1694–1697. [PubMed: 19892944] A comprehensive analysis of skin, gut and oral microbiota in the same individuals. 57. Grice EA, et al. Topographical and temporal diversity of the human skin microbiome. Science. 2009; 324:1190–1192. [PubMed: 19478181] A comprehensive analysis of skin microbiota across 20 sites. 58. Gao Z, Tseng CH, Pei Z, Blaser MJ. Molecular analysis of human forearm superficial skin bacterial biota. Proc. Natl Acad. Sci. USA. 2007; 104:2927– 2932. [PubMed: 17293459] 59. Chiller K, Selkin BA, Murakawa GJ. Skin microflora and bacterial infections of the skin. J. Investig. Dermatol. Symp. Proc. 2001; 6:170–174. 60. Roth RR, James WD. Microbial ecology of the skin. Annu. Rev. Microbiol. 1988; 42:441–464. [PubMed: 3144238] 61. Emter R, Natsch A. The sequential action of a dipeptidase and a β-lyase is required for the release of the human body odorant 3-methyl-3 sulfanylhexan1-ol from a secreted Cys-Gly-( S ) conjugate by Corynebacteria. J. Biol. Chem. 2008; 283:20645–20652. [PubMed: 18515361] 62. Decreau RA, Marson CM, Smith KE, Behan JM. Production of malodorous steroids from androsta-5,16-dienes and androsta-4,16-dienes by Corynebacteria and other human axillary bacteria. J. Steroid Biochem. Mol. Biol. 2003; 87:327– 336. [PubMed: 14698214] 63. Natsch A, Gfeller H, Gygax P, Schmid J, Acuna G. A specific bacterial aminoacylase cleaves odorant precursors secreted in the human axilla. J. Biol. Chem. 2003; 278:5718–5727. [PubMed:12468539] 64. Leyden JJ, McGinley KJ, Holzle E, Labows JN, Kligman AM. The microbiology of the human axilla and its relationship to axillary odor. J. Invest. Dermatol. 1981; 77:413–416. [PubMed:7288207] 65. Cheung, Y.F., Fung, C., and Walsh, C. "Stereochemistry of propionylcoenzyme A and pyruvate carboxylations catalyzed by transcarboxylase." 1975. Biochemistry 14(13), pg 2981. 66. Bojar, R., and Holland, K. "Acne and propionibacterium acnes." 2004. Clinics in Dermatology 22(5), pg. 375-379. 67. Rust, Susanne (4 February 2012). "UC Berkeley Bacteria Study: Research Shows Humans A Major Source Of Germs". Huffington Post. San Francisco. Retrieved 2012-04-06. 68. Kiatpapan P., Murooka Y. Genetic manipulation system in propionibacteria. Journal of Bioscience and Bioengineering. 93 (1) (pp 1-8), 2002 69. Woese, C. R. (1987). "Bacterial evolution". Microbiological Reviews. 51 (2): 22171. doi:10.1128/MMBR.51.2.221271.1987. PMC 373105. PMID 2439888. 70. Collins, M. D. (2004). "Corynebacterium caspium sp. nov., from a Caspian seal (Phoca caspica)". International Journal of Systematic and Evolutionary Microbiology. 54 (3): 925–8. doi:10.1099/ijs.0.02950-0. PMID 15143043. 71. Poetsch, A. (2011). "Proteomics of corynebacteria: From biotechnology workhorses to pathogens". Proteomics. 11 (15): 3244– 3255. doi:10.1002/pmic.201000786. PMID 21674800. 72. Burkovski A (editor). (2008). Corynebacteria: Genomics and Molecular Biology. Caister Academic Press. ISBN 978-1-904455-30-1.[page needed] 73. Harris LG, Foster SJ, Richards RG (December 2002). "An introduction to Staphylococcus aureus, and techniques for identifying and quantifying S. aureus adhesins in relation to adhesion to biomaterials: review". European Cells & Materials. 4: 39–60. doi:10.22203/ecm.v004a04. PMID 14562246. 74. Jacquemyn H, Lenaerts M, Brys R, Willems K, Honnay O, Lievens B (2013). "Among-population variation in microbial community structure in the floral nectar of the bee-pollinated forest herb Pulmonaria officinalis L." PLOS One. 8 (3): e56917. doi:10.1371/journal.pone.0056917. PMC 3594240. PMID 23536759. 75. Madigan M, Martinko J, eds. (2005). Brock Biomlogy of Microorganisms (11th ed.). Prentice Hall. ISBN 978-0-13-144329-7.[page needed] 76. Takahashi T, Satoh I, Kikuchi N (April 1999). "Phylogenetic relationships of 38 taxa of the genus Staphylococcus based on 16S rRNA gene sequence analysis". International Journal of Systematic Bacteriology. 49 (2): 725– 8. doi:10.1099/00207713-49-2-725. PMID 10319495. 77. Kloos, W.; Schleifer, KH. Bergey's Manual of Systematic Bacteriology. PHA, S.; S, M.; ME, S.; JG, H., editors. Baltimore: Williams & Wilkins; 1986. 78. Kloos WE, Musselwhite MS. Distribution and persistence of Staphylococcus and Micrococcus species and other aerobic bacteria on human skin. Appl Microbiol 1975;30:381–385. [PubMed: 810086] 79. Rogers KL, Fey PD, Rupp ME. Coagulase-negative staphylococcal infections. Infect Dis Clin North Am 2009;23:73–98. [PubMed: 19135917] 80. Chu VH, et al. Coagulase-negative staphylococcal prosthetic valve endocarditis--a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study. Heart. 2009;95:570– 576. [PubMed] [Google Scholar] 81. Miragaia M, Thomas JC, Couto I, Enright MC, de Lencastre H. Inferring a population structure for Staphylococcus epidermidis from multilocus sequence typing data. J Bacteriol 2007;189:2540–2552. [PubMed: 17220222] 82. Uckay I, et al. Foreign body infections due to Staphylococcus epidermidis. Ann Med. 2009;41:109–119. [PubMed] [Google Scholar] 83. Li M, Wang X, Gao Q, Lu Y. Molecular characterization of Staphylococcus epidermidis strains isolated from a teaching hospital in Shanghai, China. J Med Microbiol 2009;58:456–461. [PubMed: 19273641] 84. Zhang YQ, et al. Genome-based analysis of virulence genes in a non-biofilmforming Staphylococcus epidermidis strain (ATCC 12228). Mol Microbiol 2003;49:1577–1593. [PubMed: 12950922] 85. Faurschou M, Borregaard N. Neutrophil granules and secretory vesicles in inflammation. Microbes Infect. 2003;5:1317–1327. [PubMed] [Google Scholar] 86. Yao Y, Sturdevant DE, Otto M. Genomewide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into the pathophysiology of S. epidermidis biofilms and the role of phenol-soluble modulins in formation of biofilms. J Infect Dis. 2005;191:289–298. [PubMed] [Google Scholar] 87. Khardori N, Yassien M, Wilson K. Tolerance of Staphylococcus epidermidis grown from indwelling vascular catheters to antimicrobial agents. J Ind Microbiol. 1995;15:148–151. [PubMed] [Google Scholar] 88. Duguid IG, Evans E, Brown MR, Gilbert P. Effect of biofilm culture upon the susceptibility of Staphylococcus epidermidis to tobramycin. J Antimicrob Chemother. 1992;30:803–810. [PubMed] [Google Scholar] 89. Ryan KJ, Ray CG, eds. (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 293–4. ISBN 978-0-8385-8529-0. 90. Facklam R (October 2002). "What happened to the streptococci: overview of taxonomic and nomenclature changes". Clin. Microbiol. Rev. 15 (4): 613– 30. doi:10.1128/CMR.15.4.613-630.2002. PMC 126867. PMID 12364372. 91. Wang, Kun; Lu, Wenxin; Tu, Qichao; Ge, Yichen; He, Jinzhi; Zhou, Yu; Gou, Yaping; Nostrand, Joy D Van; Qin, Yujia; Li, Jiyao; Zhou, Jizhong; Li, Yan; Xiao, Liying; Zhou, Xuedong (10 March 2016). "Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus". Scientific Reports. 6 (1):22943. Bibcode:2016NatSR...622943W. doi:10.1038/srep22943 .PMC 4785528. PMID 26961389. 92. Handelsman J. Metagenomics: application of genomics to uncultured microorganisms. Microbiol Mol Biol Rev. 2004;68:669–85. 93. Maccaferri S, Biagi E, Brigidi P. Metagenomics: key to human gut microbiota. Dig Dis. 2001;29:525–30. 94. Monira S, Nakamura S, Gotoh K, et al. Gut microbiota of healthy and malnourished children in bangladesh. Front Microbiol. 2011;2:228. 95. Carpi G, Cagnacci F, Wittekindt NE, et al. Metagenomic profile of the bacterial communities associated with Ixodes ricinus ticks. PLoS One. 2011;6:e25604. 96. Riesenfeld CS, Schloss PD, Handelsman J. Metagenomics: genomic analysis of microbial communities. Annu Rev Genet. 2005;38:525–52. 97. Shendure J, Ji H. Next-generation DNA sequencing. Nat Biotechnol. 2008;26:1135–45 98. Cox-Foster DL, Conlan S, Holmes EC, et al. A metagenomic survey of microbes in honey bee colony collapse disorder. Science. 2007;318:283–7. 99. Harismendy O, Ng PC, Strausberg RL, et al. Evaluation of next generation sequencing platforms for population targeted sequencing studies. Genome Biol. 2009;10:R32. 100. Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444:1027–31. 101. Palenik B, Ren Q, Tai V, Paulsen IT. Coastal Synechococcus metagenome reveals major roles for horizontal gene transfer and plasmids in population diversity. Environ Microbiol. 2009;11:349–59. 102. Biddle JF, Fitz-Gibbon S, Schuster SC, Brenchley JE, House CH. Metagenomic signatures of the Peru Margin subseafloor biosphere show a genetically distinct environment. Proc Natl Acad Sci U S A. 2008;105:10583– 8. 103. Edwards RA, Rodriguez-Brito B, Wegley L, Haynes M, Breitbart M, et al. Using pyrosequencing to shed light on deep mine microbial ecology. BMC Genomics. 2006;7:57. 104. Chen K, Pachter L. Bioinformatics for whole-genome shotgun sequencing of microbial communities. PLoS Comput Biol. 2005;1:106–12. 105. Lazarevic V, Whiteson K, Gaia N, et al. Analysis of the salivary microbiome using culture-independent techniques. J Clin Bioinforma. 2012;2:4. 106. Shah N, Tang H, Doak T, et al. Comparing bacterial communities inferred from 16S rRNA gene sequencing and shotgun metagenomics. Pac Symp Biocomput. 2011:165–76. 107. Jeraldo P, Chia N, Goldenfeld N. On the suitability of short reads of 16S rRNA for phylogeny-based analyses in environmental surveys. Environ Microbiol. 2011;13:3000–9. 108. Kim M, Morrison M, Yu Z. Evaluation of different partial 16S rRNA gene sequence regions for phylogenetic analysis of microbiomes. J Microbiol Methods. 2011;84:81–7. 109. Chevreux B, Wetter T, Suhai S. Genome sequence assembly using trace signals and additional sequence information computer science and biology. Proc German Conf Bioinform. 1999;99:45–56. 110. Grice EA, Kong HH, Conlan S, et al. Topographical and temporal diversity of the human skin microbiome. Science. 2009;324:1190–2. 111. Grice EA, Kong HH, Renaud G, et al. A diversity profile of the human skin microbiota. Genome Res. 2008;18:1043–50. 112. Kong HH, Oh J, Deming C, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012;22:850–9. 113. Courtois S, Cappellano CM, Ball M, et al. Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products. Appl Environ Microbiol. 2003;69:49–55. 114. Borkowski AW, Gallo RL. The coordinated response of the physical and antimicrobial peptide barriers of the skin. J. Invest. Dermatol. 2011; 131:285– 287. [PubMed: 21228809] 115. Braff MH, Bardan A, Nizet V, Gallo RL. Cutaneous defence mechanisms by antimicrobial peptides. J. Invest. Dermatol. 2005; 125:9–13. [PubMed: 15982297] 116. Cogen AL, et al. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis a normal resident of the skin. J. Invest. Dermatol. 2010;130:192–200. [PubMed: 19710683] 117. Strober W. Epithelial cells pay a Toll for protection. Nature Med. 2004; 10:898–900. [PubMed:15340409] 118. Fukao T, Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 2003; 24:358–363. [PubMed: 12860525] 119. Cogen AL, et al. Staphylococcus epidermidis antimicrobial δ -toxin (phenolsoluble modulin-γ) cooperates with host antimicrobial peptides to kill Group A Streptococcus. PLoS ONE. 2010; 5:e8557. [PubMed: 20052280] 120. Lai Y, et al. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nature Med. 2009; 15:1377–1382. [PubMed: 19966777] This analysis demonstrated that products of a skin commensal can modulate the innate immune response. 121. Lai Y, et al. Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defence against bacterial skin infections. J. Invest. Dermatol. 2010; 130:2211–2221. [PubMed: 20463690] 122. Nomura I, et al. Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J. Allergy Clin. Immunol. 2003; 112:1195–1202. [PubMed:14657882] 123. Nomura I, et al. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J. Immunol. 2003; 171:3262–3269. [PubMed:12960356] 124. Gudjonsson JE, et al. Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin. J. Invest. Dermatol. 2009; 129:2795–2804. [PubMed: 19571819] 125. Ong PY, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 2002; 347:1151–1160. [PubMed: 12374875] 126. de Jongh GJ, et al. High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis. J. Invest. Dermatol. 2005; 125:1163–1173. [PubMed: 16354186] 127. Owen CM, Chalmers RJ, O’Sullivan T, Griffiths CE. A systematic review of antistreptococcal interventions for guttate and chronic plaque psoriasis. Br. J. Dermatol. 2001; 145:886–890. [PubMed: 11899140] 128. Luana de Fátima Alves, Cauã Antunes Westmann, Gabriel Lencioni Lovate, Guilherme Marcelino Viana de Siqueira, Tiago Cabral Borelli, María-Eugenia Guazzaroni. Review of Metagenomic Approaches for Understanding New Concepts in Microbial Science. 2018; 2312987.