The Role of Systematic review and Meta-Analysis in Scientific research- Pubrica.com

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META ANALYSIS &
SYSTEMATIC REVIEW
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META ANALYSIS
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Writing Meta Analysis
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Pubrica has extensive experience in conducting meta-analysis
a quantitative, formal, epidemiological study design used to
systematically assess the results of previous research to derive
conclusions about that body of research.
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As a general principle, generating, summarizing, and understanding
the best available evidence are essential for establishing the
benefits and safety of interventions.
A well designed and implemented meta-analysis study can be a
great benefit to society.
While meta-analysis has the potential to be a powerful tool in
evaluating health care treatments and interventions, there are
many potential pitfalls and problems that are yet to be resolved.
Introduction
A poorly performed meta-analysis can perpetuate biases from illconceived studies or lead to false conclusions.
Contd..
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This, in turn, can cause consumers and caregivers, who frequently access
results of meta-analysis through websites and popular press, to form
incorrect conclusions and can result in inappropriate medical decisions.
While the idea behind combining studies to improve precision and power
is straightforward, the actual implementation of the process is difficult.
Those who act or react based on meta-analysis should understand the
various biases that could be incorporated into a review.
Examples of some potential pitfalls in meta-analysis include publication
bias, pipeline bias, and English language bias.
In addition, combining studies that are not similar in study design,
population, methods of analysis or outcome definitions can lead to biases
as well,which may result in spurious conclusions being drawn.
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Guidelines for Reporting:
Moreover, a useful guide to improve reporting of systematic reviews and metaanalysis is the PRISMA (Preferred Reporting Items for Systematic reviews and Metaanalysis) statement that replaced the QUOROM (Quality of Reporting of Metaanalysis) statemen.
Detailed Literature Search:
We include all relevant studies, because loss of studies can lead to bias in the study.
Typically, published papers and abstracts are identified by a computerized literature
search of electronic databases that can include PubMed
(www.ncbi.nlm.nih.gov./entrez/query.fcgi), ScienceDirect (www.sciencedirect.com),
Scirus (www.scirus.com/srsapp ), ISI Web of Knowledge
(https://www.isiwebofknowledge.com), Google Scholar (https://scholar.google.com)
and CENTRAL (Cochrane Central Register of Controlled Trials,
https://www.mrw.interscience.wiley.com/cochrane/ochrane_clcentral_articles_fs.htm).
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Heterogeneity
Statistical
Analysis
Heterogeneity is inherent in metaanalysis, not a problem to be solved.
It includes clinical components (eg,
diversity in patient populations or
interventions) and statistical
components (eg, random differences).
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SYSTEMATIC REVIEW
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Performing a rigorous systematic review is multi-step process, which includes
Identifying a well-defined focused clinically relevant question,
Systematic
Review
Developing a detailed review protocol with strict inclusion and exclusion criteria,
Systematic literature search of multiple databases and unpublished data, in
consultation with a medical librarian,
Meticulous study identification and
Systematic data abstraction, by at least two sets of investigators independently,
Risk of bias assessment, and
Thoughtful quantitative synthesis through meta-analysis where relevant.
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General
Structure
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Formulate the research question
Search for studies
Selection of studies
Data collection
Methodology quality assessment
Results are analysed and presented
Findings are interpreted.
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