2016
BUSINESS REPORT
POWERPOINT TEMPLATE
Your life can be enhanced, and your happiness enriched, when
you choose to change your perspective.
01
02
03
04
METABOLISM
REHABILITATION
MECHANICS
CONCLUSION
Nothing we can do will change it.
The future is before us and dynamic.
Everything we do will affect it.
Nothing we can do will change it.
The future is before us and dynamic.
Everything we do will affect it.
Nothing we can do will change it.
The future is before us and dynamic.
Everything we do will affect it.
Nothing we can do will change it.
The future is before us and dynamic.
Everything we do will affect it.
Your life can be enhanced, and your happiness enriched, when
you choose to change your perspective.
01
Your life can be enhanced, and your happiness enriched, when
you choose to change your perspective.
Just for todayI will try to live through this day
only and not tackle my whole life problem at
once. I can do something for twelve hours
that would appall me if I had to keep it up for
a lifetime.
01
test
subject
Study 1 Subjects 12 Men
and women
Study 2 included three
male subjects
experimental
method
Bone and calcium
biochemistry
detection
method
Serum Total Calcium:
Isotope Labeling
Whole blood calcium ion:
sensitive electrode
technology
Urine detection: Atomic
absorption
spectrophotometer
01
• Calcium intake and absorption decreased
• Urinary calcium excretion increased
01
Bone loss
Osteoporosis
Bone resorption ＞ bone formation
bone calcium overflow
01
Metabolism — Serotonin
 Neurotransmitter regulation of bone metabolism (the subject of increasing
interest)
• Serotonin (5-hydroxytryptamine or 5-HT) : amine neurotransmitter
• circulating serotonin may affect bone metabolishm
• plays a role as a regulator of craniofacial morphogenesis
 Design the experiment
• female rats (2 months) with serotonin subcutaneously (s.c.) daily for 3 months
vs controls were given saline
• DXA scans, micro-computed tomography (mCT), histomorphometry, and mechanical testing.
• studying bone architecture, bone histomorphometry, mechanical testing in vivo
01
Metabolism — Serotonin
• Total body BMD was significantly higher in the serotonin group
• Total body bone area was significantly lower in the serotonin group
• stiffness higher compared to controls
• serotonin seems to have important in vivo effects on bone
• speculate that humans receiving serotonin is likely similar to those seen
in rats
Gustafsson B I et al. Long-term serotonin administration leads to higher bone mineral density, affects bone architecture, and leads to higher femoral bone
stiffness in rats[J]. Journal of Cellular Biochemistry, 2006, 97(6):1283-91.
03
Rehabilitation
For Bone Loss
Physical Exercise：Zheng Xuan
Medicine: Dou Dan dan
03
Main Countermeasures
PART ONE
01
physical exercise
PART TWO
PART THREE
02
03
medicine
mechanical
stimulation
03
 Transcutaneous pins--L4 &great trochanter of femur
Physical Exercise
01
running on the treadmill
They wear a harness and
bungee system that provides
forces maintain attachment
to the treadmill to simulate
the running effect in 1 G.
aerobic exercise
Main methods
3 typical ways
•
•
•
normal resistive training
flywheel resistance training
isometric resistive training
03
02
resistive exercise
vibration
vibration platform
High loading frequencies
can provide an osteogenic
stimulus via mechanical
vibration devices
03
Resistive Exercise
Writer
Countermeasure
Duration
Results
17 weeks
Prevention of BMD loss in total hip,
calcaneus, pelvis and total body,
significantly increased bone metabolism
markers and net calcium balance
Flywheel resistance training
During bed rest
90 d
BMC(bone mineral content) losses of the
tibia were mitigated
Static isometric training
During bed rest
resistance training
in space
2 mouths
Enhance bone formation
6 weeks
Help maintaining bone mass when
combined with adequate energy intake
Shackelford HEM
(normal resistance training)
During bed rest
Rittweger
Swezey
Smith
• Three methods during bed rest can all effectively reduce bone loss
and promote bone metabolism
• Smith did a study in real space
• showed that 6 weeks of resistance training can helped maintaining
bone mass
 Transcutaneous pins--L4 &great trochanter of femur
03 Combinatorial Countermeasure
01
running on the treadmill
They wear a harness and
bungee system that provides
forces maintain attachment
to the treadmill to simulate
the running effect in 1 G.
aerobic exercise
Combination
3 typical methods

•
•
•
During bed rest
normal resistive training
flywheel resistance training
isometric resistive training
03
02
resistive exercise
vibration
vibration platform
High loading frequencies
can provide an osteogenic
stimulus via mechanical
vibration devices
03
Combinatorial Countermeasure-1
Vibration combined with resistive exercise-Belavy
• 21 male subjects were divided into three groups:
The result
that to
this
kind ofresistive
combination
RVE:
additionshows
of vibration
high-load
exercisemay
 RE: resistive exercise alone
be more
efficient than resistive exercise alone in
 CTR:
no exercise
preventing bone loss at some sites .
• Perform exercises on this special device
 Vibration platform
Galileo Space exercise device
 head-down tilt on movable platform
03
Combinatorial Countermeasure-2
Aerobic combined with resistive exercise-Smith
• 16 women participated in a 60-day, 6°head-down-tilt BR and

It can
be seen
that theto
combination
were
assigned
randomly
two groups:of resistive and
 EX:aerobic
alternating
between
supine treadmill
d wk−1)
exercise
can mitigate
the bone(4loss
and flywheel resistive exercise (3 d wk−1).
effectively.
 CON:
performed no countermeasure
Flywheel resistive exercise
03
Medicine therapy
Inhibition of osteoclast
formation
Both of them
Promote the formation
of osteoblast
04
Medicine therapy
Ⅰ
Ⅱ
Ⅲ
Alendronate
The Chinese
herbal
medicine
Curcumin
Based
on the hypothesis
of the
oxidative
stress mechanism,
curcumin,
a natural
antioxidant
W and free
The
researchers
foundalendronate
that
Chinese
medicine
can of
effectively
promote
the
proliferation
of radical
osteoblasts,
At
the
cellular level,
has herbal
an affinity
for sites
bone resorption,
particularly
osteoclasts.
scavenger
were
selected
as
experimental
drugs
for
anti-microgravity
bone
loss.
In
recent
years,
it
has
been found
thus combating
bone
loss caused
weightlessness.
Becausethat
of the
overall
regulation
traditional
Chinese
LeBlanc
A tested
baboons
and by
rats,
the results showed
oral
alendronate
willofinhibit
the formation
of
that
curcumin
reverses
ovariectomy-induced
osteoporosis
in
rats,
and
also
reduces
bone
loss
caused
by
medicine, drug
side effects,
etc., inactivity
they have on
been
tested
in the aerospace field.
osteoclasts,
reduce
long-term
thewidely
impact
of bone.
periodontitis, Improve bone fiber structure and improve bone mineral density.
01
bone mechanical properties
DXE
Tail suspension model to
simulate microgravity developed
based on NASA-designed tail
suspension system
In CON, BMD had increased by 24.2%
after14 days. However, BMD% growth in
TS decreased by 0.08%
Three-point bending testing
In the three-point bending testing, the breaking load, stiffness and
energy absorption all decreased significantly in the TS group.
01
nanoindentation
Method
·
After polishing, the specimens were glued
onto a polycarbonate holder with a fluid drainage
system. The indent locations were precisely
determined using a microscope at a calibrated
distance away from the indenter tip. After a 30-s
hold periodunder a constant peak load, the
indenter was unloaded
· The Oliver–Pharr method was used to
determine the elastic modulus and hardness
from the nanoindentation data
H ： hardness
Fmax ：the maximum force
Ac ：contact area
S ：contact stiffness
Er ： reduced modulus
v ： Poisson’s ratio
Er（elastic modulus） 1140 Gpa
Vi（Poisson’s ratio)： 0.07
04
Research Direction
I thought to do
I’m dong
I think I will do
04
Ultrasonic Resonance Spectrum (RUS)
ADVANTGES
1
2
3
4
STEPS
1 Density & Size
2 Theoretical Resonant Frequencies
3 Measured Frequency Peaks
4 Elastic Tensor and Engineering Modulus
Full Elastic Tensor
Nondestructive Experiment
Small Size Sample
More Repeatable & Accurate
03
Work Division
Zheng Xuan
Li Yanan
Cell Signaling
Pathway
PART ONE
PART TWO
Metabolism
Rehabilitation
Dou Dandan
Chen Haoxiang
Materials Science
Water Treatment
Microgravity
Bone
Zhang Xiaoxue
Ultrasonic Signal
Processing
Liu Xiaoli
Medical Big Data
Mechanism
Bone Biochemistry
Zhang Qiang
Rehabilitation
Engineering
Biochemistry
PART THREE
Connection
PART FOUR
Li Yang
Puhysiological
Signal Acquiring
Team Photo
Team Photo
2017
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