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Esomeprazole

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Discussion On
Product
Introduction
Objectives
Upon completion of this lecture the attendance
will know:
 About the Disease
 Product Profile
 Marketing Tactic
Gastroesophageal Reflux Disease
(GERD)
 NSAID-associated gastric ulcer
 H. pylori infection
Gastroesophageal Reflux Disease (GERD)
Condition in which the acidic stomach contents
(food or liquid) move backward from the stomach
into the esophagus
Gastroesophageal Reflux Disease (GERD)
 Signs and symptoms includeHeartburn
Chest pain
dysphagia
Dry cough
Hoarseness or sore throat
acid reflux
Sensation of a lump in throat
Gastroesophageal Reflux Disease (GERD)
 Causes
Frequent acid reflux
A hiatal hernia may contribute
Other factors that may contribute– Alcohol use
– Overweight
– Pregnancy
– Smoking
Gastroesophageal Reflux Disease (GERD)
 Complications
 Esophageal stricture
 Esophageal ulcer
 Barrett's esophagus
Gastroesophageal Reflux Disease (GERD)
 Treatment
 Lifestyle Changes
 Medications
 Surgery
 Endoscopic options
Gastroesophageal Reflux Disease (GERD)
 Lifestyle Changes
 Stop smoking
 Stop alcohol consumption
 Lose weight if needed
 Eat small meals
 Wear loose-fitting clothes
 Avoid lying down for 3 hours after a meal
 Raise the head of your bed 6 to 8
NSAID-associated gastric ulcer
Peptic ulcer
 Open sores
 Classification
Duodenum (called duodenal ulcer)
Esophagus (called esophageal ulcer)
Stomach (called gastric ulcer)
NSAID-associated gastric ulcer
Causes:
 Infection with the bacterium, Helicobacter pylori
(H. pylori)
 Long-term use of nonsteroidal anti-inflammatory
drugs (NSAIDs), such as aspirin and ibuprofen
 Hyperacidity, which may be related to genetics,
lifestyle (stress, smoking), and certain foods
NSAID-associated gastric ulcer
Mechanism of Action of NSAIDs:
Cell Membrane Phospholipid of injured tissue
Opioids inhibits
Arachidonic Acid
NSAID inhibits
Cyclooxygen (COX)
COX 1
Prostaglandin
Renal
Function
Platelet
Function
Gastric
Mucosal
Protection
COX 2
Prostaglandin
Smooth
Muscle
Contraction
Pyrexia
Pain
Inflam
mation
H. pylori infection
H. Pylori




Spiral-shaped bacteria
Grow in the digestive tract
Have a tendency to attack the stomach lining
Impairs the protective mechanism of G.I Tract
H. pylori eradication
Combination drug therapy regimens:
 A proton pump inhibitor (PPI) plus clarithromycin
plus amoxicillin or metronidazole
 A proton pump inhibitor plus a bismuth
compound plus metronidazole plus tetracycline
At a glance Product Profile
INDICATION
 Treatment of Gastroesophageal Reflux Disease (GERD)
 Healing of erosive esophagitis
 Maintenance of healing of erosive esophagitis
 Symptomatic Gastroesophageal Reflux Disease
(GERD)
 Risk Reduction of NSAID-associated gastric ulcer
 H. pylori eradication (Triple therapy)
At a glance Product Profile
DOSAGE & ADMINISTRATION
Recommended adult dosage schedule of Esomeprazole:
At a glance Product Profile
USE IN PREGNANCY AND LACTATION
US FDA Pregnancy Category – ‘C’
SIDE EFFECT
Side effects reported with Esomeprazole include headache,
diarrhea and abdominal pain
At a glance Product Profile-MAO of Epizol
At a glance Product Profile
PPI Vs H2 Receptor Blockers
 PPIs shut down the proton pumps in the
stomach
 H2 Blockers work by blocking the histamine
receptors in acid-producing cells in the
stomach
At a glance Product Profile
At a glance Product Profile
Feature, Advantage, Benefit (FAB)
No.
Feature
Advantage
Benefit
1
S-isomer of
Omeprazole
High bioavailability (90%)
Better acid control
2
Pka2 value is higher
than other PPIs
High activation rate
Patients gets faster
relief
Suitable for all types of
metabolizers
Patient can take it very
confidently
3
4
5
Effective even for
rapid metabolizers
Equally effective in
both Helicobacter
pylori (+ve) or (-ve)
patients
Low profile of drugdrug interactions
Epizol prevents the chance
of treatment failure
A preferred choice for
patients having more than
one medicine
Patients can avoid
endoscopy procedure
Epizol can be taken
confidently along with
other medicines
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