Test Bank For Rang & Dale’s Pharmacology by Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod J

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Test Bank For Rang & Dale’s Pharmacology by Humphrey
P. Rang, Maureen M. Dale, James M. Ritter, Rod J
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Description
Rang & Dale’s Pharmacology by Humphrey P. Rang, Maureen M. Dale, James M.
Ritter, Rod J
Rang: Rang & Dale’s Pharmacology, 7th Edition
Test Bank
Chapter 5: Cell proliferation, apoptosis, repair and regeneration
MULTIPLE CHOICE
1. In the death receptor pathway, activation of tumor necrosis factor receptors causes the
receptors to trimerize and complex an adapter protein, thereby leading to activation of
1.
2.
3.
4.
5.
mitochondrial pathways
caspase-8
pro-apoptotic factor Bcl-2
a p53 protein
DNA transcription factors
Answer b: caspase-8
1. The activation of primitive stem cells so as to replace a damaged tissue is called
1.
2.
3.
4.
5.
healing
repair
restoration
regeneration
rejuvenation
Answer d: regeneration
1. Defective apoptosis may contribute to the development of
1.
2.
3.
4.
5.
cancer
Alzheimer’s disease
myocardial infarction
aplastic anemia
stroke
Answer a: cancer
1. The activation of caspase-3 leads to
1.
2.
3.
4.
5.
activation of transcription factors
inhibition of transcription factors
activation of the anti-apoptotic pathway
fragmentation of genomic DNA
stabilization of cell membranes
Answer d: fragmentation of genomic DNA
1. Bortemozib causes accumulation of an apoptotic-promoter protein by inhibiting
1.
2.
3.
4.
5.
mitochondrial DNA
suvivin
matrix metalolproteinases
pro-apoptotic Bcl-2
the proteasome
Answer e: the proteasome
1. Matrix metalloproteinases are responsible for
1.
2.
3.
4.
5.
inhibition of neoplastic cell growth
adjusting the cell cytoskeleton
degradation of extracellular matrix
initiating angiogenesis
activation of the cell cycle
Answer c: degradation of extracellular matrix
1. Antisense compounds active against antiapoptotic factors are potentially useful for treating
1.
2.
3.
4.
5.
myocardial infarction
leukemia
Parkinson’s disease
multiple sclerosis
impaired wound healing
Answer b: leukemia
1. Bevacizumab is a monoclonal antibody that targets
1.
2.
3.
4.
5.
caspase-3
metalollproteinase
cyclin
vascular endothelial growth factor
promoters of apoptosis
Answer d: vascular endothelial growth factor
1. Mitochondria participate in apoptosis by releasing
1.
2.
3.
4.
5.
apoptotic protease activating factor
caspase-9
cytochrome c
p53 protein
inhibitors of apoptosis
Answer c: cytochrome c
1.
Progress through the cell cycle is stimulated by
1.
2.
3.
4.
5.
cyclin-dependent kinases
phosphorylated Rb protein
check point factors
p53 protein
inhibitors of kinases
Answer a: cyclin-dependent kinases