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acrabstracts org abstract high type i interferon activity is associated with active class E2 85 A2 E2 85 A3 lupus nephritis in european american lupus patients independent of dsdna antibodies

High Type I Interferon Activity Is Associated with Active
Class Ⅲ/Ⅳ Lupus Nephritis in European-American Lupus
Patients Independent of dsDNA Antibodies
Taro Iwamoto1, Jessica M. Dorschner2, Mark A. Jensen1, Danielle Vsetecka2, Shreyasee Amin3,
Ashima Makol4, Floranne C. Ernste5, Thomas Osborn3, Kevin Moder3, Vaidehi Chowdhary6 and
Timothy B. Niewold1, 1Colton Center for Autoimmunity, New York University, New York, NY, 2Division
of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 3Rheumatology,
Mayo Clinic, Rochester, MN, 4Rheumatology, Mayo Clinic College of Medicine and Science, Rochester,
MN, 5Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, 6Internal Medicine, Division of
Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN
Meeting: 2017 ACR/ARHP Annual Meeting
Date of rst publication: September 18, 2017
Keywords: interferons and lupus nephritis, Lupus
Date: Monday, November 6, 2017
Session Type: ACR Poster Session B
Session Title: Systemic Lupus
Erythematosus – Human Etiology and
Pathogenesis Poster I
Session Time: 9:00AM-11:00AM
Background/Purpose: Lupus nephritis (LN) is one of the most severe types of organ involvement in
systemic lupus erythematosus (SLE), despite the recent advances in immunosuppressive therapies.
High type Ⅰ interferon (IFN) is a heritable risk for SLE, and some previous studies have suggested a
link between high IFN and lupus nephritis. However, little is known about the relationships between
high levels of IFN and the subtypes of LN, and whether IFN is more associated with anti-dsDNA
antibodies or with clinical nephritis.
Methods: We studied 197 EA SLE patients and measured type Ⅰ IFN in sera by performing WISH IFN
bioassay as described previously. Subtypes of LN were con rmed by renal biopsy review.
Complements, anti-dsDNA and other auto-antibodies were measured in the clinical laboratory, and
standard clinical cut-o s were used to de ne a positive result. Non-parametric analyses were used to
compare IFN data with the antibody data.
Results: IFN level and SLEDAI score was positively correlated (r=0.30, p<0.0001, Spearman) in our
cross-sectional evaluation. EA subjects with a high levels of IFN (IFN score ≥2) were more likely to
have renal manifestations compared to the subjects with a low levels of IFN(IFN score <2) (p<0.001,
OR=3.4, Fisher’s exact test). In addition, the incidence rate of class Ⅲ/Ⅳ LN was signi cantly higher
among patients with a high levels of IFN compared to the patients with low levels of IFN (p=0.0197,
OR=5.1, Fisher’s exact test). Notably, IFN level was signi cantly higher in active class Ⅲ/Ⅳ LN
compared to inactive class Ⅲ/Ⅳ LN (p<0.001 Mann-Whitney U) and this was not observed in non-class
Ⅲ/Ⅳ LN populations.. Positivity of ds-DNA antibody did not show signi cant di erence between
inactive class Ⅲ/Ⅳ LN and active class Ⅲ/Ⅳ LN, and the correlation between SLEDAI and IFN was
driven by the dsDNA and complement variables.
Conclusion: Our data support an association between type I IFN and class III/IV nephritis that is
independent of overall SLEDAI and anti-dsDNA antibodies, suggesting that IFN is involved in renal
pathogenesis. These data also suggest that IFN could predict renal disease activity or the future risk
of developing LN, especially class Ⅲ/Ⅳ LN in EA SLE patients.
Disclosure: T. Iwamoto, None; J. M. Dorschner, None; M. A. Jensen, None; D. Vsetecka, None; S.
Amin, None; A. Makol, None; F. C. Ernste, None; T. Osborn, None; K. Moder, None; V. Chowdhary,
None; T. B. Niewold, None.
To cite this abstract in AMA style:
Iwamoto T, Dorschner JM, Jensen MA, Vsetecka D, Amin S, Makol A, Ernste FC, Osborn T, Moder
K, Chowdhary V, Niewold TB. High Type I Interferon Activity Is Associated with Active Class Ⅲ/Ⅳ
Lupus Nephritis in European-American Lupus Patients Independent of dsDNA Antibodies
[abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/high-type-iinterferon-activity-is-associated-with-active-class-%e2%85%a2%e2%85%a3-lupus-nephritis-ineuropean-american-lupus-patients-independent-of-dsdna-antibodies/. Accessed May 28, 2019.
ACR Meeting Abstracts - https://acrabstracts.org/abstract/high-type-i-interferon-activity-isassociated-with-active-class-%e2%85%a2%e2%85%a3-lupus-nephritis-in-european-american-lupuspatients-independent-of-dsdna-antibodies/
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