Lorenzo’s Oil Movie Guide
Name
1.
Lorenzo begins to experience problems at school and at home. What symptoms of the disease first appear?
2.
When Lorenzo is diagnosed with (ALD) Adrenoleukodystrophy the doctor explains the prognosis for this disorder? What does
the doctor tell Mr. and Mrs. Odone?
3.
Lorenzo inherited this disease from which parent and explain why?
4.
The biochemical basis of this disease is related to the metabolism of what molecules?
5.
How does ALD affect the myelin sheath of Lorenzo's neurons?
6.
What are two ways that long chain fatty acids get into the body?
7.
How do proteins, nucleic acids and lipids contribute to ALD?
8.
What type of oil do the Odones give to Lorenzo after learning about the “Polish Rat” study?
9.
What is an “orphan drug”?
10. Why can’t Lorenzo swallow his saliva?
Vocabulary
Metabolism
Orphan drug
Enzyme
Biosynthesis
ALD
symposium
11. What does the paper clip model demonstrate to Augusto? What is his dream?
12. When Augusto explains the dream to the doctor, the paper clip model is shown to have this property of an enzyme reaction?
13. What is the name of the second oil? What plant is this oil extracted from?
14. What is the medical basis of using this oil?
15. Who is Lorenzo’s rat? Why is it this person?
16. Why are the doctors and family concerned about toxicity?
17. After the administration of the oil, how does Lorenzo’s condition begin to change?
18. When the Odone’s present their findings how do the parents in the foundation respond?
19. Augusto gets a new idea for a “cure” for Adrenoleukodystrophy from shaking puppies. Explain.
20. .How would a cure for the ALD boys offer hope to other neurological conditions?