The Language Of Medicine Chapters 8 and 9 Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 1 Introduction Sexual Reproduction This is the union of the nuclei of ovum and sperm cell. Ovum and sperm cells are called gametes. Each gamete contains half the number of chromosomes of a normal body cell. Fertilization - Chromosomes Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 2 Introduction Gametes (ovum and sperm cell) Gametes are produced in the gonads. Female gonads are the ovaries; male gonads are the testes. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 3 Introduction Fertilization An ovum leaves the ovaries and travels through the fallopian tube. Fertilization takes place if sperm cells. are present and unite with the ovum. Conception Fertilized egg implants then divides to form a ball of cells, called a zygote (and later an embryo and then a fetus). Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 4 Organs of the Female Reproductive System Organs of the female reproductive system, lateral view. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 5 QUICK QUIZ: 1. Fertilized egg implants, then divides to form a ball of cells, called a… A. embryo B. fetus C. follicle D. zygote Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 6 Pg. 41 Organs of the female reproductive system anterior view Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 7 Organs of the Female Reproductive System ● The Breast sagittal view Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 8 Menstruation and Pregnancy MENSTRUAL CYCLE - Ovulation Day 1-5 (Menstrual period) Blood cells, endometrial cells, and glandular secretions discharge from the body. Day 6-12 Estrogen aids repair of endometrium. The ovum grows in the follicle. Day 13-14 (Ovulatory period) Egg leaves the ovary and passes through the fallopian tube. Day 15-28 Corpus luteum secretes progesterone; uterus lining builds up. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 9 Menstruation and Pregnancy MENSTRUAL CYCLE - Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 10 Menstruation and Pregnancy PREGNANCY - If fertilization occurs, the egg implants in the uterine endometrium. - Placenta forms within the uterine wall. - Amnion holds the fetus in an amniotic cavity. - Nutrients, oxygen and wastes exchange between fetus and mother. - Placenta produces human chorionic gonadotropin (hCG). What is IVF? Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 11 Menstruation and Pregnancy A, Implantation in the uterus B, Embryo’s relationship to the placenta Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 12 QUICK QUIZ: 2. Corpus luteum secretes this monthly to build up the lining of the uterus. A. B. C. D. adrenaline estrogen progesterone hCG Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 13 QUICK QUIZ: 3. During Pregnancy what does the placenta secrete? A. adrenaline B. hCG C. progesterone D. estrogen Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 14 Homework: Pg. 42, 37-38 (will be stamped on Monday) Quiz tomorrow: Female Combining Forms, Suffixes, and Prefixes Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 15 Menstruation and Pregnancy PREGNANCY - Progesterone maintains placenta development. - Uterus expands as fetus grows. - Normal delivery fetal position is cephalic presentation (head first). Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 16 Menstruation and Pregnancy PREGNANCY Three Phases of Labor 1. Dilation of the cervix 2. Birth of the infant 3. Delivery of the placenta Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 17 Menstruation and Pregnancy A, Cephalic presentation and delivery of placenta vaginal birth, amniotic sac, C-Section Birth, water birth elephant birth, giraffe birth Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 18 Hormonal Interactions Pituitary secretes: Follicle-stimulating hormone (FSH) Luteinizing hormone (LH) Pituitary stops producing FSH and LH During pregnancy With oral contraceptives Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 19 Hormonal Interactions Menopause Gradual ending of the menstrual cycle Normally begins between 45 and 55 Falling estrogen levels Option for estrogen replacement therapy (careful consideration of risks required) Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 20 Introduction - Pg. 26 ⬤ ⬤ ⬤ The male sex cell is called a spermatozoon, or sperm cell. The sperm cell carries its nuclear hereditary material, or chromosomes, in its head region. The tail consists of a flagellum, which makes the sperm cell mobile. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 21 Introduction ⬤ Only one spermatozoon out of 300 million sperm cells released during ejaculation can fertilize a single female ovum. ⬤ If more than one egg is present in the fallopian tubes during ejaculation, multiple fertilizations are possible. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 22 Introduction Fraternal twins. Notice the 6-weekold embryos in two separate amniotic sacs. ⬤ Twins resulting from the fertilization of separate ova by separate sperm cells are called fraternal twins. ⬤ Twins resulting from the fertilization of a single egg by a single sperm are called identical twins. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 23 Introduction ⬤ The organs of the male reproductive system are designed to produce and release billions of sperm cells throughout the man’s lifetime. ⬤ The hormone called testosterone is responsible for the bodily characteristics of the male (such as beard, pubic hair, and deeper voice). Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 24 Male Reproductive Parts - 48 Scrotum: External Sac that holds the testes Testes: Male Gonad; produces testosterone and sperm Seminiferous Tubules: produce sperm Epididymis: Carries and houses the sperm from the seminiferous tubules to the vas deferens. Vas Deferens: Carrie the sperm towards the urethra during ejaculation. Penis: Male external organ of reproduction Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 25 Seminal Vesicles: Secrete fluid into the vas deferens; this is the bulk of the semen. Ejaculatory Duct: Tube where semen enters the urethra Prostate Gland: secretes more fluid for semen. Cowper’s Gland: Provides lubrication during sexual intercourse Urethra: transport system for urine and semen Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 26 Anatomy (cont’d) Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 27 ⬤ Internal structure of the testis and the epididymis Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 28 Anatomy ⬤ The passage of sperm from the seminiferous tubules to the outside of the body Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 29 QUICK QUIZ: 1. Which term refers to the skin covering the tip of the penis? A. B. C. D. stroma vas deferens prepuce seminal vesicle Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 30 Terminology Combining Form Meaning andr/o balan/o cry/o crypt/o epididym/o gon/o hydr/o orch/o, orchi/o, orchid/o male penis cold hidden epididymis seed water, fluid testis, testicle Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 31 Terminology (cont’d) Combining Form Meaning pen/o prostat/o semin/i sperm/o terat/o test/o varic/o vas/o zo/o penis prostate gland semen, seed spermatozoa, semen monster testis, testicle varicose veins vessel duct animal life Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 32 Terminology (cont’d) SUFFIXES Suffix Meaning ⬤ -genesis formation ⬤ -one hormone ⬤ -pexy fixation, put in place ⬤ -stomy new opening Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 33 Pathology: Uterus Carcinoma of the cervix Malignant cells within the cervix Cervicitis Inflammation of the cervix Carcinoma of the endometrium Malignant tumor of the uterus Endometriosis Endometrial tissue located outside the uterus Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 34 Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 35 Pathology: Uterus Fibroids Benign tumors of the uterus Figure shows location of uterine fibroids. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 36 Pathology: Gynecological and Breast Ovaries Ovarian carcinoma Malignant tumor of the ovary Ovarian cysts Collections of fluid within a sac in the ovary Fallopian Tubes Pelvic inflammatory disease Examples: salpingitis, oophoritis, endometritis Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 37 Pathology: Breast Carcinoma of the breast Image A shows (arrows) mammogram of invasive carcinoma of the breast. Image B is a cut section of invasive ductal carcinoma of the breast. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 38 Pathology: Pregnancy Abruptio placentae Premature separation of the implanted placenta Choriocarcinoma Malignant tumor of the placenta Ectopic pregnancy Misplaced implantation of egg Placenta previa Preeclampsia Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 39 Pregnancy Issues Multiple Births: Fraternal Twins – two eggs, two sperm – different DNA Identical Twins – one egg, one sperm: Fertilized egg splits into two separate zygotes, same DNA Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 40 Pathology: Neonatal Down syndrome – extra chromosome on #21 Erythroblastosis fetalis – Rh factor – blood incompatibility Hyaline membrane disease Hydrocephalus – fluid on the brain Meconium aspiration syndrome – baby swallows first bowel movement Pyloric stenosis – narrowing of pyloric valve -vomiting Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 41 Pathology: Neonatal APGAR SCORING CHART Assessment of newborn Scoring 1 to 5 mins after birth Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 42 Pathologic Conditions Testicular Torsion Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 43 Pathologic Conditions (cont’d) Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 44 Pathologic Conditions Hypospadias ⬤ Surgical repair involves excising a portion of the prepuce, wrapping it around a catheter, suturing it to the distal part of the urethra, bringing it to the end of the penis. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 45 Sexually Transmitted Diseases STDs ➢ Gonorrhea - Inflammation of the genital tract Mucosa – berry shaped bacteria ➢ Burning while urinating, pus discharge ➢ Treated with Antibiotics Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 46 human papilloma virus (HPV) Infection of skin – warts, cause cancer Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 47 syphilis • Spiral shaped bacterium • Chancre but goes away • Damage to brain, spinal cord and heart if left untreated. • Penicillin Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 48 Herpes Genitalis Infection of the skin and mucous membranes – HSV Type 2 No cure, very dangerous to babies during delivery. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 49 Chlamydial Infection • Bacteria • Symptoms appear within 3 weeks – burning sensation in urethra, yellow discharge • Women are asymptomatic • Antibiotics cure the infection but can cause PID in women Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 50 Laboratory Tests and Clinical Procedures ⬤ Laboratory Tests ➢ PSA test ➢ semen analysis Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 51 QUICK QUIZ: 2. What does the PSA test for? A. B. C. D. levels of infection sperm mobility sperm motility levels of an antigen Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 52 Laboratory Tests and Clinical Procedures Clinical Procedures ➢ transurethral resection of the prostate--TURP Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 53 Laboratory Tests and Clinical Procedures (cont’d) Clinical Procedures ➢ Vasectomy ➢ Vasectomy procedure Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 54 Laboratory Tests and Clinical Procedures (cont’d) Clinical Procedures ➢ Circumcision – removal of the foreskin of the penis ➢ Procedure Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 55 QUICK QUIZ: 4. Which term means “no sperm or semen are produced”? A. B. C. D. aspermia oligospermia anorchism spermolytic Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 56 Clinical Tests and Procedures Clinical tests Pap test (Pap smear) explanation Pregnancy test Mammogram Procedures X-rays Ultrasound ultrasound Gynecological procedures Procedures during pregnancy Tubal Ligation Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 57 Clinical Procedures Gynecological procedures Conization ➢Removal of a coneshaped section of the cervix. ➢Figure shows LEEP for cone biopsy ➢Cervical cancer Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 58 Clinical Procedures (cont’d) GYNECOLOGICAL PROCEDURES Laparoscopic oophorectomy ➢A, Ovary placed in plastic bag. ➢B, Extracted through the laparoscope ⬤ In vitro fertilization (IVF) ➢ A, Ovary placed in plastic bag. ➢ B, Extracted through the laparoscope Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 59 Clinical Tests and Procedures Procedures Procedures during pregnancy Amniocentesis - procedure Needle placement guided by ultrasound images. Copyright © 2011, 2008, 2005 by Saunders, an imprint of Elsevier Inc. All rights reserved. 60