The Description, advantages and
disadvantages
Billy Matt Xavier Valladolid
Mharjon Caliniagan
Angelyn Gemino
Arvin Merelos
Lemsi Segovia
Lester Espina
What is Gene Therapy?
 Gene Therapy is a method of experimental gene
transplantation that replaces or adds new gene to a
target cell that are defective which either cures a
disease or improve a characteristic.
•The procedure occurs when a genetically modified
carrier (usually viruses) called vectors are inserted
into a specific tissue to infect it with the new gene.
In this case, Adenovirus
infects a cell that deliver the
new gene to the nucleus in
order to improve the
defected cell’s function.
 There are two types of gene therapy depending on
what cells are treated:
Somatic gene therapy
Germline gene therapy
These are methods on how the gene therapy is approach to
follow the objective
Gene augmentation therapy
 Adding a gene to a defective cell that will make the
cell’s function to operate normally.
 The DNA consist of a working and compatible gene
needed for a cell that lacks of it.
 The new functioning gene then process protein on
what the cell is missing.
Gene inhibition therapy
 The objective of this is to inhibit defective cells that are
active on producing inappropriate cell works such as
cancer cells.
 The process works by inhibiting a faulty gene that will
interferes its process thus halt the cell’s unwanted
activity.
Killing defective cells
 The objective is to kill the target cells by applying specific
genes.
 This method is easily targeted to all cells so mistake can
happen if a healthy cell is unintentionally targeted.
 Two ways can this happened:
 Genes that creates a toxic substance, killing the cell.
 Genes that produces a protein marker expressing the immune
system to attack the target cell.
Advantages
 The ability to replace defective cells
 Comes with the untapped potential of biotechnology
 Eradication of diseases
Disadvantages
 Possible damage to the gene pool
 Immoral objectives from modifications of human
capabilities
 Manifestation of several disorders from new genes or
if the procedure fails.