Pharynx and pterygopalatine fossa J. B RADLEY BARGER, PH D JB BARGER@ UAB .EDU DENT 1250, 2019 LEARNING OBJECTIVES 1.Describe the boundaries of the pterygopalatine fossa and the openings by which this fossa communicates with other areas of the head. 2.Describe the contents of the pterygopalatine fossa, especially the branches of the maxillary nerve and the structures they supply. 3. Describe the bones and cartilages forming the external nose and the walls of the nasal cavity. 4. Describe the nerve and blood supply of the nasal cavity. 5. Describe the functional significance of the paranasal sinuses and describe where they drain into the nasal cavity. 6.Describe the clinical significance of the relationships of the paranasal sinuses and be familiar with their nerve and blood supply. LEARNING OBJECTIVES 1.Describe the boundaries of the pterygopalatine fossa and the openings by which this fossa communicates with other areas of the head. 2.Describe the contents of the pterygopalatine fossa, especially the branches of the maxillary nerve and the structures they supply. 3. Describe the bones and cartilages forming the external nose and the walls of the nasal cavity. 4. Describe the nerve and blood supply of the nasal cavity. 5. Describe the functional significance of the paranasal sinuses and describe where they drain into the nasal cavity. 6.Describe the clinical significance of the relationships of the paranasal sinuses and be familiar with their nerve and blood supply. BOUNDARIES OF PTERYGOPALATINE FOSSA 1. The PTERYGOPALATINE FOSSA is a wedge-shaped space deep on the side of the skull. It derives its name from the fact that its post. wall is formed by the lat. pterygoid plate of the sphenoid and its med. wall by the perpendicular plate of the palatine. The ant. wall is the post. surface of the maxilla. The ant. and post. walls converge inferiorly. Sphenoid bone (lateral pterygoid plate) Palatine bone (perpendicular plate) Maxillary bone COMMUNICATIONS OF PTERYGOPALATINE FOSSA THE PTERYGOPALATINE FOSSA COMMUNICATES WITH OTHER SPACES IN THE HEAD VIA A NUMBER OF OPENINGS: 1) via the PTERYGOMAXILLARY FISSURE with the infratemporal fossa (laterally) 2) via the INF. ORBITAL FISSURE with the orbit (anterosuperiorly) 3) via the SPHENOPALATINE F. with the nasal cavity (medially) COMMUNICATIONS OF PTERYGOPALATINE FOSSA 4) via the (GR. & LSR.) PALATINE CANALS & FORAMINA with the palate (inferiorly) 5) via the F. ROTUNDUM with the mid. cranial fossa (posteriorly) 6) via the PTERYGOID CANAL with the f. lacerum (middle cranial fossa) (posteriorly). 7) via the PALATOVAGINAL CANAL (PHARYNGEAL CANAL) with the nasopharynx (posteriorly) These openings allow imp. structures to enter and leave the pterygopalatine fossa and should be identified on a skull in the lab. MAXILLARY NERVE (V2) Zygomatic n. V1 V ganglion Sensory root of V V3 V2 Pterygopalatine ganglion and nerves TWO OF THE MOST IMP. CONTENTS OF THE PTERYGOPALATINE Zygomaticotemporal n. FOSSA ARE THE MAXILLARY N. (V2) & Zygomaticofacial n. THE PTERYGOPALATINE GANGLION. V2 enters the fossa posteriorly (via f. rotundum) and leaves Infraorbital n. the fossa Anterior superior alveolar n. anterosuperiorly (via inf. orbital fissure) to become the infraorbital Mucosa of maxillary sinus n. Dental and gingival branches Middle superior alveolar n. Posterior superior alveolar n. V2 HAS NUMEROUS BRANCHES, INCLUDING THE FOLLOWING: 1. ZYGOMATIC N. --- This nerve enters the orbit and splits into Zygomatic n. the ZYGOMATICOTEMPORAL & ZYGOMATICOFACIAL NN. V1 Zygomaticotemporal n. which are cutaneous to the temple and face. V ganglion Zygomaticofacial n. 2. INFRAORBITAL N. --- This is the terminal part of the maxillary Sensory root of V n. Before reaching the infraorbital f. to supply skin of the face, the infraorbital n. gives off the MID. SUP.ALVEOLAR N. Infraorbital n. to the maxillary premolars and the ANT. SUP. ALVEOLAR N. Anterior superior alveolar n. to the maxillary incisors and canine. These nerves run within V3 the bone of the wall of the maxillary sinus and also supply V2 Mucosa of maxillary sinus the mucous membrane of the sinus. Dental and gingival branches 3. POST. SUP. ALVEOLAR N. --- This nerve arises directly from Pterygopalatine ganglion V2. It enters the post. sup. alveolar foramina and canals to and nerves Middle superior alveolar n. supply the maxillary molars and the mucosa of the maxillary Posterior superior alveolar n. sinus. 4. PTERYGOPALATINE NN. --- These short nerves connect V2 with the pterygopalatine ganglion. They contain primarily sensory fibers (GSA) of V2 which pass through the ganglion WITHOUT SYNAPSE to be distributed to the pharynx, palate and nasal cavity. The branches of distribution to these areas are illustrated in the following plate (next slide). In this MEDIAL VIEW of the MAXILLARY pterygopalatine ganglion some of the OTHER (INDIRECT) BRANCHES OF V2 can be seen: 1) PHARYNGEAL BR. --Sensory to the roof of the pharynx (above the auditory tube). Posterior superior 2) GR. & LSR. PALATINE NN. lateral nasal brs. (V2) -- Sensory to the hard and soft palates (resp.). Posterior inferior lateral nasal br. (V2) 3) POST. SUP. & POST. INF. LAT. NASAL BRS. --- Sensory to the lateral wall of the nasal cavity. 4) NASOPALATINE N. --Nasopalatine n. (V2) (cut) Sensory to the septum (med. (passing to nasal septum) wall) of the nasal cavity. Pterygopalatine ganglion NERVE (V2) (CONTINUED) Greater palatine n. (V2) Maxillary n. (V2) Greater petrosal n. (VII) (presynaptic parasympathetic) Nerve of pterygoid canal Pharyngeal br. (V2) Lesser palatine n. (V2) Also note the PTERYGOID CANAL (containing a nerve of the same name) which passes from the f. lacerum through the sphenoid to open into the post. wall of the pterygopalatine fossa. MAXILLARY NERVE (V2) (CONTINUED) Maxillary n. (V2) Posterior superior lateral nasal brs. (V2) Posterior inferior lateral nasal br. (V2) Greater petrosal n. (VII) (presynaptic parasympathetic) Nerve of pterygoid canal Nasopalatine n. (V2) (cut) (passing to nasal septum) Pharyngeal br. (V2) Pterygopalatine ganglion Greater palatine n. (V2) Lesser palatine n. (V2) Pterygopalatine Nerve (Vidian) of pterygoid canal ganglion Lacrimal gland Deep petrosal n. Greater petrosal n. VII Nerves to palate, nose & pharynx Int. carotid n. Sup. cervical ganglion T1 & T2 spinal nerves Lateral horn of T1 & T2 Presynaptic symp. Postsynaptic symp. Presynaptic parasymp. Postsynaptic parasymp. PTERYGOPALATINE GANGLION (SCHEMA) 1. The PTERYGOPALATINE GANGLION is a parasympathetic ganglion. Only presynaptic parasympathetic fibers from the gr. petrosal br. of VII synapse in this ganglion (GSA fibers from V2 and postsynaptic sympathetic fibers from the deep petrosal n. pass through the ganglion without synapse). Postsynaptic parasympathetic fibers supply the glands of the orbit (lacrimal gl.), roof of the nasopharynx, palate and nasal cavity (secretomotor). (Note: the postsynaptic sympathetic fibers in the deep petrosal n. are destined mainly for blood vessels). The 3RD PART OF THE MAXILLARY A. also lies in the pterygopalatine fossa. It has numerous brs., the most imp. of which are: 1) INFRAORBITAL A. --- In the floor of the orbit this artery gives off the MID. SUP. ALVEOLAR A. to the premolars and the ANT. SUP. ALVEOLAR A. to the incisors and canine. 2) POST. SUP. ALVEOLAR A. --Supplies the molar teeth. 3) DESCENDING PALATINE A. --Not shown. 4) SPHENOPALATINE A. --- Not shown. MAXILLARY ARTERY (3RD PART) Infraorbital a. Post. superior alveolar a. Mid. superior alveolar a. Ant. superiro alveolar a. Maxillary a. (1st part) Inferior alveolar a. & n. Ext. carotid a. MAXILLARY ARTERY (3RD PART)(CONTINUED) Sphenopalatine a. Infraorbital a. Post. superior alveolar a. Descending palatine a. Left and right greater palatine aa. Left and right lesser palatine aa. Maxillary a. (3 part) Maxillary artery (3rd rd part) 1. The other BRS. OF THE 3RD PART OF THE MAXILLARY A. are shown here. The DESCENDING PALATINE A. splits into two brs. --- the gr. and lsr. palatine aa. which supply the hard and soft palates (resp.). The SPHENOPALATINE A. passes through the foramen of the same name to supply the nasal cavity. 2. Note that the 2nd part of the maxillary a. (in the infratemporal fossa) passes through the pterygomaxillary fissure to enter the pterygopalatine fossa. LEARNING OBJECTIVES 1.Describe the boundaries of the pterygopalatine fossa and the openings by which this fossa communicates with other areas of the head. 2.Describe the contents of the pterygopalatine fossa, especially the branches of the maxillary nerve and the structures they supply. 3. Describe the bones and cartilages forming the external nose and the walls of the nasal cavity. 4. Describe the nerve and blood supply of the nasal cavity. 5. Describe the functional significance of the paranasal sinuses and describe where they drain into the nasal cavity. 6.Describe the clinical significance of the relationships of the paranasal sinuses and be familiar with their nerve and blood supply. EXTERNAL NOSE (SKELETAL FRAMEWORK) Frontal bone Nasal bones Maxilla (frontal pr.) Lateral processes of septal cartilage Septal cartilage Lat. crus (grtr. alar cart.) Med. crus (grtr. alar cart.) Alar fibrofatty tissue 1. The EXTERNAL NOSE has both a BONY & CARTILAGINOUS FRAMEWORK. The bones are the nasal, frontal and maxilla (frontal pr.). The cartilages are the septal , lat. nasal and greater alar. EXTERNAL NOSE (MUSCLES, NERVES & VESSELS) Procerus m. Dorsal nasal a. Infratrochlear n. Ext. nasal a. & n. Nasalis m. (transverse pt.) Infraorbitl a. & n. Lateral nasal a. Depressor septi nasi m. 1. Various mm. of ext. nose (mm. of facial expression, innervated by VII). 2. Cutaneous innervation by brs. of V1 and V2. 3. Vessels by brs. of ophthalmic and facial aa. REGIONS OF NASAL CAVITY 1. The nose consists of two parts: the external nose (visible on face) and the nasal cavity (part which extends further back into the skull). 2. The nasal cavity consists of three regions: A. Nasal vestibule is a small dilated space just internal to the naris that is lined with skin and contains hairs (filter air) B. Respiratory region is the largest part of the nasal cavity. It has a rich neurovascular supply, and is lined by respiratory epithelium composed mainly of ciliated and mucous cells (thus air is warmed and moistened as is passes over this epithelium). The nasal cavity is literally an “air conditioner”. C. Olfactory region is small. It is lined by olfactory epithelium which contains olfactory neurons, the axons of which constitute the olfactory n. (I) (The sense of smell in man is poor compared to animals such as dogs). NASAL CONCHAE AND MEATUSES 1. The nasal cavity has a roof, floor (palate), a medial wall (septum) and a lateral wall (A). 2. Projecting from the lateral wall are three curved shelves of bone termed the sup., mid., and inf. conchae (B) 3. Inferior to each concha is a space (passage) termed the sup., mid. and inf. meatus (C) (Coronal section). The space superior to the sup. concha is the sphenoethmoidal recess. 4. The air stream passes through the nares, meatuses and choanae to the nasopharynx (D) 5. The conchae serve to increase the surface area of the respiratory mucosa which covers them. MEDIAL WALL OF NASAL CAVITY (NASAL SEPTUM) Frontal bone (nasal spine) Nasal bone Vomer Groove for nasopalatine n. Septal cartilage Incisive canal Palatine process of maxilla 1. The NASAL SEPTUM (MED. WALL) is formed by three elements: 1) the septal cartilage 2) the Cribriform plate of ethmoid perpendicular plate of the ethmoid and 3) Perpendicular plate of ethmoid the vomer. The nasal septum in adults is Body of sphenoid frequently deviated to one side; if severe, surgical correction may be necessary to restore free breathing. 2. The FLOOR of the nasal cavity is formed by the hard palate, ie, the palatine pr. of the maxilla and the horizontal plate of the palatine. 3. The ROOF of the nasal cavity has sloping ant. and post. parts and a horizontal middle part. The ant. part of the roof is composed of the nasal cartilages, nasal bone and frontal bone while the post. part is formed by the body of the sphenoid. The middle part is the cribriform ("sieve-like") plate of the ethmoid which is perforated for the bundles of the Horizontal plate of palatine olfactory n. (I). LATERAL WALL OF NASAL CAVITY Lacrimal Ethmoid bone Middle nasal concha Superior nasal concha Supreme nasal concha Sphenopalatine f. Sphenoid (med. pterygoid plate) Maxilla (frontal process) Inf. nasal concha Palatine (perpendicular plate) 1. The LAT. WALL of the nasal cavity is uneven and is formed by numerous bones: maxilla, lacrimal, ethmoid, inf. nasal concha, perpendicular plate of palatine and med. pterygoid plate of sphenoid. The sup. and mid. conchae (and sometimes the supreme concha) are parts of the ethmoid; the inf. concha is a separate bone. Note that the palatine bone is L-shaped; the perpendicular plate and horizontal plate contribute to the lat. wall and floor (resp.) of the nasal cavity. Note also the sphenopalatine f. in the posterosuperior part of the lat. wall. LATERAL WALL OF NASAL CAVITY (CONCHAE PARTLY REMOVED) Ethmoidal bulla Middle nasal concha (cut away) Semilunar hiatus Uncinate process In this dissection the MID. NASAL CONCHA HAS BEEN CUT AWAY to expose some deeper structures. 1. The ETHMOIDAL BULLA is a bulge produced by the mid. ethmoidal air cells. Inferior to the bullla is a curved ridge of bone called the UNCINATE PR. Between the bulla and uncinate pr. is a curved groove, the SEMILUNAR HIATUS, which receives the openings of some of the paranasal sinuses. 1. The ethmoid bone is the KEY bone of the nasal cavity. It contributes to the roof (cribriform plate), septum (perpendicular plate) and lateral wall (ethmoidal labyrinth) of the nasal cavity. 2. The two ethmoidal labyrinths (one on each side) are box-like parts that contain the ethmoidal air cells. The middle ethmoidal air cells cause a swelling called the ethmoidal bulla. Projecting from the ethmoidal labyrinths are the superior and middle conchae. (Note that the inferior concha is a separate bone). PARTS & RELATIONSHIPS OF ETHMOID BONE Hiatus semilunaris 3. The uncinate process of the ethmoid lies below the bulla and is separated from the bulla by the hiatus semilunaris . 4. Also note crista galli of ethmid projecting into ant. cranial fossa. PARTS & RELATIONSHIPS OF ETHMOID BONE Hiatus semilunaris NERVE SUPPLY OF NASAL CAVITY 1. The NERVES OF GENERAL SENSATION (GSA) ARE BRS. OF V1 & V2. The ANT. ETHMOIDAL N. (V1) supplies the anterosuperior part of both the septum and lat. wall. The remainder of the septum is supplied by the NASOPALATINE N. (V2), while the remainder of the lat. wall is by the POST. SUP. & POST. INF. LAT. NASAL BRS. OF V2. NERVE SUPPLY OF NASAL CAVITY 2. The OLFACTORY REGION OF THE NASAL CAVITY is confined to the roof and adjacent parts of the septum and lat. wall. Bipolar olfactory neurons send their axons (SVA) through the cribriform plate of the ethmoid to end in the olfactory bulb. Loss of smell (ANOSMIA) may occur following fractures of the cribriform plate. (NB There is also a gradual loss of olfactory neurons with age (~1% per year). Since each one-half of the nasal cavity contains ~ 25 million olfactory neurons in a young adult I don't think this is something to worry about.) ARTERIAL SUPPLY OF NASAL CAVITY Region of epistaxis 1. The ARTERIAL SUPPLY to the nasal cavity is from the SPHENOPALATINE A. and the ANT. & POST. ETHMOIDAL AA. The sphenopalatine a. enters the nasal cavity through the sphenopalatine f. and divides into brs. for both the septum and lat. wall. (The ant. and post. ethmoidal aa. do the same.) 2. In the REGION OF THE ANTEROINFERIOR PART OF THE SEPTUM the sphenopalatine a. anastomoses with the septal br. of the sup. labial a. and with the gr. palatine a. This is the region where EPISTAXIS (NOSEBLEED) USUALLY OCCURS. (Epistaxis may be the result of trauma, infections or hypertension . If it is so severe that it cannot be controlled by the usual means ligation of the ext. carotid a. may be required.) LEARNING OBJECTIVES 1.Describe the boundaries of the pterygopalatine fossa and the openings by which this fossa communicates with other areas of the head. 2.Describe the contents of the pterygopalatine fossa, especially the branches of the maxillary nerve and the structures they supply. 3. Describe the bones and cartilages forming the external nose and the walls of the nasal cavity. 4. Describe the nerve and blood supply of the nasal cavity. 5. Describe the functional significance of the paranasal sinuses and describe where they drain into the nasal cavity. 6.Describe the clinical significance of the relationships of the paranasal sinuses and be familiar with their nerve and blood supply. PARANASAL SINUSES 1. The PARANASAL SINUSES are AIR-FILLED SPACES WITHIN THE FRONTAL, SPHENOID, ETHMOID AND MAXILLARY BONES. All of the sinuses are paired (even the sphenoid) and all open into the nasal cavity because they develop as outgrowths of that cavity. The paranasal sinuses are lined with mucous membranes that contain cilia. They vary considerably in size between individuals and may be asymetrical in the same person. The ethmoid sinus consists of a series of small cells (3-18) rather than a single space. 2. The FUNCTIONS which have been ascribed to the paranasal sinuses are numerous. Among these are: 1) act as resonating chambers for the voice 2) lighten the skull 3) bring about an equal distribution of weight in the head (this could explain their asymetry in some individuals) 4) add moisture (in the form of mucus) to the nasal cavity and 5) produce nitric oxide! (In a recent study it was shown that exhaled nitric oxide in humans originates mainly from the sinuses, and it was speculated that this contributes to the control of bacteria and to the functioning of the epithelial cilia). The morphology of the frontal sinus is also useful in forensic medicine because it can be used to identify skeletal remains. 3. DRAINAGE of the sinuses is by ciliary action and perhaps by suction during blowing of the nose. Sometimes the sinuses become infected (sinusitis) and do not drain properly. DEVELOPMENT OF PARANASAL SINUSES Orbit Frontal sinus Birth 1 year 4 years 7 years 12 years Adult Nasal septum Old age Maxillary sinus Molar tooth Palate 1. The paranasal sinuses are either absent (eg., frontal) or very small (eg., maxillary) at birth. 2. Growth of the sinuses during childhood is imp. in altering the size and shape of the face, and in adding resonance to the voice during adolescence. DRAINAGE OF PARANASAL SINUSES Frontal sinus Opening into sphenoethmoidal recess Probe passing via frontonasal duct into middle meatus Sphenoid sinus Superior nasal meatus w/openings of posterior ethmoidal cells Ethmoidal bulla Openings of mid. ethmoid cells Semilunar hiatus w/openings of anterior ethmoidal cells Opening of nasolacrimal duct Opening of maxillary sinus 1. The OPENINGS OF THE PARANASAL SINUSES INTO THE NASAL CAVITY are shown (note that the mid. and inf. conchae have been removed). The SPHENOID SINUS opens through its ant. wall into the sphenoethmoidal recess. The FRONTAL SINUS opens into the ant. part of the mid. meatus. The MAXILLARY SINUS opens into the post. part of the semilunar hiatus. The ETHMOIDAL CELLS are divided into ant., mid. and post. groups. The ANT. GROUP opens into the ant. part of the semilunar hiatus, the MID. GROUP onto the ethmoidal bulla and the POST. GROUP into the sup. meatus. The NASOLACRIMAL DUCT (from the lacrimal sac) empties into the ant. part of the inf. meatus. RELATIONSHIPS OF THE FRONTAL SINUS Brain (in ant. cranial fossa) Frontal sinus Nasal cavities Orbit 1. The frontal sinus is related to the orbit and nasal cavity inferiorly, and to the anterior cranial fossa superiorly. 2. The nerve and blood supply are by the supraorbital n. and a. Nasal cavities RELATIONSHIPS OF ETHMOID SINUS Ethmoidal cells 1. The ethmoid sinus is related to the nasal cavity medially and to the orbit laterally. Careless exploration of posterior ethmoid air cells has resulted in blindness by damaging the optic n. 2. Nerve and blood supply to ethmoid sinus is by the anterior and posterior ethmoidal nn. and aa. Medial wall of orbit (lamina papyracea) Optic n. RELATIONSHIPS OF SPHENOID SINUS 1. Sphenoid sinus is related to pituitary gland superiorly, nasopharynx inferiorly, nasal cavity anteriorly (note opening in its anterior wall leading to sphenoethmoidal recess), and the pons posteriorly. Pituitary gland can be approached surgically through nasal cavity and sphenoid sinus. 2. Nerve and blood supply to sinus is via pharyngeal n. (V2) and posterior ethmoidal n. (V1), and corresponding aa. Pituitary gland Opening of sphenoid sinus into nasal cavity Pons Nasopharynx Sphenoid sinus RELATIONSHIPS OF SPHENOID SINUS 1. Sphenoid sinuses (note bony partition) are related laterally to the cavernous sinuses (which contain ICAs). Int. carotid a. in cavernous sinus Sphenoid sinus Nasopharynx Pituitary gland RELATIONSHIPS OF MAXILLARY SINUS Opening of sinus into middle meatus of nasal cavity Maxillary sinus Orbital surface Facial surface Roots of teeth Infratemporal surface 1. The MAXILLARY SINUS is the largest of the paranasal sinuses. Note its RELATIONSHIPS: 1) FACE (anteriorly) 2) INFRATEMPORAL & PTERYGOPALATINE FOSSAE (posteriorly) 3) ORBIT (superiorly) *4) ALVEOLAR PR. OF MAXILLA (WITH ROOTS OF MOLAR TEETH --- AND SOMETIMES PREMOLARS AND CANINE AS WELL) (inferiorly). The relationships of the maxillary sinus to the roots of the teeth is imp. because tooth infections can spread into the sinus. Extractions may also result in breaking off the root tips which may become lodged in the sinus. 2. The opening of the maxillary sinus into the mid. meatus is HIGH on the med. wall of the sinus --- a poor location in terms of drainage. Because of this fact the maxillary sinus is the sinus most frequently infected. (Sometimes MAXILLARY SINUSITIS IS ACCOMPANIED BY TOOTHACHE. This is because the mucosa lining of the sinus is innervated by the three superior alveolar nerves --- the same nerves that innervate the maxillary teeth. This is an example of referred pain. In some cases of sinusitis it may be necessay to surgically widen the opening into the nasal cavity. The approach used is through the thin bone of the canine fossa). 3. The three superior alveolar aa. supply blood to the sinus. LEARNING OBJECTIVES 1. Describe the functions of the pharynx. 2. Describe the different parts of the pharynx and their boundaries and relationships to each other. 3. Describe the main anatomical features seen in each part of the pharynx and their functional and clinical significance. 4. Name the layers that compose the pharyngeal wall. 5. Describe the arrangement of the muscles of the pharynx, as well as their attachments, functions and innervations. 6. Describe the mechanism of swallowing. 7. Describe the sensory innervation of the pharynx. 8. Describe the composition of the pharyngeal nerve plexus. 9. Describe the blood supply and lymphatic drainage of the pharynx. 10. Name the bony structures that form the atlanto-occipital (AO) and atlanto-axial (AA) joints and the ligaments associated with these joints. Also, describe the types of movement permitted at these joints. 11. Describe the attachments, functions and innervation of the prevertebral muscles. 12. Describe the structure of the cervical part of the sympathetic trunk and the anatomical basis for the condition known as “Horner’s syndrome.” LEARNING OBJECTIVES 1. Describe the functions of the pharynx. 2. Describe the different parts of the pharynx and their boundaries and relationships to each other. 3. Describe the main anatomical features seen in each part of the pharynx and their functional and clinical significance. 4. Name the layers that compose the pharyngeal wall. 5. Describe the arrangement of the muscles of the pharynx, as well as their attachments, functions and innervations. 6. Describe the mechanism of swallowing. 7. Describe the sensory innervation of the pharynx. 8. Describe the composition of the pharyngeal nerve plexus. 9. Describe the blood supply and lymphatic drainage of the pharynx. 10. Name the bony structures that form the atlanto-occipital (AO) and atlanto-axial (AA) joints and the ligaments associated with these joints. Also, describe the types of movement permitted at these joints. 11. Describe the attachments, functions and innervation of the prevertebral muscles. 12. Describe the structure of the cervical part of the sympathetic trunk and the anatomical basis for the condition known as “Horner’s syndrome.” SUBDIVISIONS OF THE PHARYNX NASAL CAVITY NASOPHARYNX ORAL CAVITY OROPHARYNX LARYNX C6 Trachea AIR FOOD LARYNGOPHARYNX Esophagus PHARYNX IN POSTERIOR VIEW Base of skull (5 cm) CV6 (1.5 cm) Esophagus NASOPHARYNX (MUCOSA INTACT) Pharyngeal tonsil Choana Orifice of auditory tube Pharyngeal recess Torus tubarius Torus levatorius Salpingopharyngeal fold Uvula Pharyngeal isthmus NASOPHARYNX (MUCOSA REMOVED) Cartilage of auditory tube Tensor (veli) palatini Levator (veli) palatini Salpingopharyngeus PHARYNGOTYMPANIC (AUDITORY) TUBE Nasopharynx Tympanic cavity Pharyngotympanic (auditory) tube OROPHARYNX IN ANTERIOR VIEW (BOUNDARIES OF OROPHARYNGEAL ISTHMUS) Soft palate Palatoglossal arch Dorsum of tongue Epiglottis Median glossoepiglottic fold Lateral glossoepiglottic fold Vallecula Root Body Palatopharyngeal arch Palatine tonsil Lingual tonsil Palatoglossal arch TONSILLAR BED Tonsillar br. of facial a. External palatine (paratonsillar) v. Glossopharyngeal n. (IX) Superior constrictor Choanae NASOPHARYNX Soft palate OROPHARYNX Root of tongue Epiglottis LARYNGOPHARYNX Aryepiglottic fold Piriform recess with fold over internal laryngeal n. NERVES DEEP TO MUCOSA OF PIRIFORM RECESS Internal laryngeal n. Recurrent laryngeal n. WALDEYER’S RING LEARNING OBJECTIVES 1. Describe the functions of the pharynx. 2. Describe the different parts of the pharynx and their boundaries and relationships to each other. 3. Describe the main anatomical features seen in each part of the pharynx and their functional and clinical significance. 4. Name the layers that compose the pharyngeal wall. 5. Describe the arrangement of the muscles of the pharynx, as well as their attachments, functions and innervations. 6. Describe the mechanism of swallowing. 7. Describe the sensory innervation of the pharynx. 8. Describe the composition of the pharyngeal nerve plexus. 9. Describe the blood supply and lymphatic drainage of the pharynx. 10. Name the bony structures that form the atlanto-occipital (AO) and atlanto-axial (AA) joints and the ligaments associated with these joints. Also, describe the types of movement permitted at these joints. 11. Describe the attachments, functions and innervation of the prevertebral muscles. 12. Describe the structure of the cervical part of the sympathetic trunk and the anatomical basis for the condition known as “Horner’s syndrome.” WALL OF PHARYNX 1. Mucous membrane 2. Pharyngobasilar fascia 3. Muscle layer 4. Buccopharyngeal fascia 1. The WALL OF THE PHARYNX consists of FOUR LAYERS: 1) MUCOSA (innermost) 2) PHARYNGOBASILAR FASCIA (esp. thick near the base of the skull) 3) MUSCULAR (with inner longitudinal and outer circular parts) and 4) BUCCOPHARYNGEAL FASCIA (outermost). 2. I will concentrate on the muscular layer. THREE PHARYNGEAL CONSTRICTOR MUSCLES Superior constrictor Pterygomandibular raphe Middle constrictor Inferior constrictor Esophagus 1. The OUTER LAYER OF PHARYNGEAL MUSCLES is composed of the THREE CONSTRICTORS. The fibers of the constrictors are circularly arranged with the inf. constrictor overlapping the mid. constrictor, and the mid. constrictor overlapping the sup. constrictor (like three stacked flower pots). The constrictors take their origin from bones and cartilages anteriorly and sweep back to a common insertion into a median raphe posteriorly. Thus, they contribute to the lat. and post. walls of the pharynx but not to the ant. wall. 1. The SUP. CONSTRICTOR M. originates from the pterygomandibular raphe and the bone at either end of the raphe (ie, the pterygoid hamulus and the post. end of the mylohyoid line of the mandible). The raphe also serves for part of the origin of the buccinator m. 2. The MID. CONSTRICTOR M. originates from the hyoid bone and the lower end of the stylohyoid lig. 3. The INF. CONSTRICTOR M. has two parts: 1) THYROPHARYNGEUS (originates from thyroid cartilage) and 2) CRICOPHARYNGEUS (originates from cricoid cartilage). The cricopharyngeus acts as a sphincter to prevent air from entering the esophagus (causing "gas"). Clinically the cricopharyngeus is imp. because it may undergo spasm leading to obstruction of the food channel. As a result an outpocketing of the pharyngeal wall (HYPOPHARYNGEAL DIVERTICULUM) may develop. Such a diverticulum may become so large that it may interfere with the nutrition of the individual and have to be treated surgically! 4. All three constrictor muscles insert into a midline raphe in the posterior wall of the pharynx. Pterygomandibular raphe Superior pharyngeal constrictor m. Middle pharyngeal constrictor m. Hyoid bone Thyroid cartilage Cricoid cartilage Inferior pharyngeal constrictor m. Zone of sparse muscle fibers Cricopharyngeus m. (part of inferior constrictor m.) Posterior Pharyngeal Wall: Opened Styloid process Cartilaginous part of pharyngotympanic tube Stylopharyngeus m. Salpingopharyngeus m. Palatopharyngeus m. Pharyngobasilar fascia Pharyngeal raphe Stylopharyngeus m. Superior constrictor m. Middle constrictor m. Longitudinal pharyngeal mm. Inferior constrictor m. Cricopharyngeus m. Posterior border of thyroid cartilage lamina 1. The INNER LONGITUDINAL LAYER OF PHARYNGEAL MUSCLES is composed of the stylopharyngeus, palatopharyngeus and salpingopharyngeus. The STYLOPHARYNGEUS descends from the styloid pr. and passes between the sup. and mid. constrictor mm. (useful relationship for identifying the constrictor mm. in lab). 2. The PALATOPHARYNGEUS descends from the palate. The stylo- and palatopharyngeus blend inferiorly and have a common insertion into the thyroid cartilage and wall of the pharynx. 3. The SALPINGOPHARYNGEUS is a tiny muscle which descends from the cartilage of the auditory tube ("salpinx" means tube) and blends with the palatopharyngeus. (Mechanism of Swallowing) Tensor palati m. Levator palati m. Salpingopharyngeus m. Passavant’s ridge Superior constrictor m. Palatopharyngeus m. Mylohyoid m. Stylopharyngeus m. Middle constrictor m. Inferior constrictor m. Cricopharyngeus m. Circular esophageal m. SWALLOWING (DEGLUTITION) can be described in three stages. In the FIRST STAGE, which is voluntary and occurs in the mouth, the bolus of food is pushed back into the oropharynx by the tongue and mylohyoid mm. The SECOND STAGE is involuntary and occurs in the pharynx. This is a rapid and complex stage. The respiratory passage is closed off both below (at the laryngeal inlet) and above (at the pharyngeal isthmus). The pharyngeal isthmus is closed by pulling the soft palate against the post. pharyngeal wall. The tensor and levator palati mm. move the soft palate while the uppermost fibers of the palatopharyngeus m. (Passavant's ridge) pull the pharyngeal wall forward. The pharynx is then elevated by the three longitudinal muscles (stylo-, palato- and salpingopharyngeus) to receive the bolus. This is followed by the serial contraction of the three constrictors which push the bolus toward the esophagus. The THIRD STAGE occurs in the esophagus. It is also involuntary and occurs rapidly. Peristaltic action of the esophageal musculature forces the bolus inferiorly toward the stomach. FOUR GAPS IN THE PHARYNGEAL MUSCULATURE Various structures pass through gaps in the pharyngeal musculature: 1. Levator palati m. passes through the gap between the base of the skull and the sup. constrictor m. 2. Stylopharyngeus m. and IX pass through the gap between the sup. and mid. constrictor mm. 3. Int. laryngeal n. and sup. laryngeal a. pass through the gap between the mid. and inf. constrictor mm. 4. Rec. laryngeal n. and inf. laryngeal a. pass deep to the inferior border of the inf. constrictor m. Levator palati Superior constrictor Stylopharyngeus & IX Internal laryngeal n. & superior laryngeal a. Middle constrictor Inferior constrictor Recurrent laryngeal n. & inferior laryngeal a. LEARNING OBJECTIVES 1. Describe the functions of the pharynx. 2. Describe the different parts of the pharynx and their boundaries and relationships to each other. 3. Describe the main anatomical features seen in each part of the pharynx and their functional and clinical significance. 4. Name the layers that compose the pharyngeal wall. 5. Describe the arrangement of the muscles of the pharynx, as well as their attachments, functions and innervations. 6. Describe the mechanism of swallowing. 7. Describe the sensory innervation of the pharynx. 8. Describe the composition of the pharyngeal nerve plexus. 9. Describe the blood supply and lymphatic drainage of the pharynx. 10. Name the bony structures that form the atlanto-occipital (AO) and atlanto-axial (AA) joints and the ligaments associated with these joints. Also, describe the types of movement permitted at these joints. 11. Describe the attachments, functions and innervation of the prevertebral muscles. 12. Describe the structure of the cervical part of the sympathetic trunk and the anatomical basis for the condition known as “Horner’s syndrome.” MOTOR INNERVATION OF PHARYNX Glossopharyngeal n. (to stylopharyngeus) 1. The MOTOR INNERVATION TO THE PHARYNGEAL MUSCLES is via IX and X. The STYLOPHARYNGEUS (shown but not labelled) is innervated by a small twig from the glossopharyngeal n. (IX). Note how IX "winds around" the stylopharyngeus on its way to the tongue. ALL OF THE OTHER PHARYNGEAL MM. receive their innervation from the pharyngeal br. of X. (In both cases the functional component is SVE). Pharyngeal branch of X (to other pharyngeal mm.) X (Medial view) Trigeminal (V2) via pharyngeal branch of pterygopalatine ganglion Glossopharyngeal (IX) via pharyngeal plexus via tonsillar branches taste plus general sensation via lingual branches Vagus (X) via internal laryngeal n. Trigeminal n. (V) Glossopharyngeal n. (IX) Vagus n. (X) Facial n. (VII) 1. The SENSORY INNERVATION OF THE PHARYNX is via three cranial nerves. ABOVE THE ORIFICE OF THE AUDITORY TUBE the nerve supply is V2 (GSA). BETWEEN THE AUDITORY TUBE AND LARYNGEAL INLET the innervation is by IX (GVA). BELOW THE LARYNGEAL INLET the innervation is by X (also GVA). There may be some overlap in the regions supplied. 2. The GAG REFLEX is elicited when the posterior wall of the oropharynx is touched (eg, with a toothbrush). This causes elevation of the soft palate and movement of the tongue. The afferent limb of the reflex is IX (and perhaps X); the efferent limb involves X and XII. PHARYNGEAL PLEXUS OF NERVES Pharyngeal br. of IX (GVA) Pharyngeal br. of X (SVE) The PHARYNGEAL PLEXUS OF NERVES is a network of fibers located primarily on the mid. constrictor m. It receives contributions from three sources: 1) pharyngeal br. of IX (GVA, sensory to mucosa of pharynx) 2) pharyngeal br. of X (SVE, motor to most of the pharyngeal muscles) and 3) pharyngeal br. of sup. cervical sympathetic ganglion (not shown)(GVE, vasomotor). ARTERIAL SUPPLY TO PHARYNX 1. The ARTERIAL SUPPLY TO THE PHARYNX is from the ascending pharyngeal a. and the sup. and inf. thyroid aa. Ascending pharyngeal a. Superior constrictor m. Ascending pharyngeal a. Superior thyroid a. Inferior thyroid a. VENOUS DRAINAGE OF PHARYNX 1. The PHARYNGEAL PLEXUS OF VV. lies on the post. wall of the pharynx. This plexus drains into the IJV. Retropharyngeal nodes Jugulodigastric node Superior deep cervical nodes 1. LYMPHATIC DRAINAGE OF THE PHARYNX is to the retropharyngeal and sup. deep cervical nodes. The jugulodigastric node (the uppermost deep cervical node) receives most of the lymph from the palatine tonsil and is therefore sometimes referred to as the tonsillar node. NEUROVASCULAR RELATIONSHIPS 1. The last four cranial nerves and the sympathetic trunk are related to the pharynx. 2. IX winds around stylopharyangeus m. X descends in carotid sheath (look also for sup. laryngeal br. of X) XI passes into deep surface of SCM. XII curves inferiorly and anteriorly toward tongue, crossing lateral to both carotid aa. (Note that XII is closely bound to X at skull base and at first appears to be a branch of X). 3. Sympathetic trunk has been pulled medially in this slide. It lies just posterior to carotid sheath. XI IX XII Sympathetic trunk Com. & int. carotid aa., IJV, X LEARNING OBJECTIVES 1. Describe the functions of the pharynx. 2. Describe the different parts of the pharynx and their boundaries and relationships to each other. 3. Describe the main anatomical features seen in each part of the pharynx and their functional and clinical significance. 4. Name the layers that compose the pharyngeal wall. 5. Describe the arrangement of the muscles of the pharynx, as well as their attachments, functions and innervations. 6. Describe the mechanism of swallowing. 7. Describe the sensory innervation of the pharynx. 8. Describe the composition of the pharyngeal nerve plexus. 9. Describe the blood supply and lymphatic drainage of the pharynx. 10. Name the bony structures that form the atlanto-occipital (AO) and atlanto-axial (AA) joints and the ligaments associated with these joints. Also, describe the types of movement permitted at these joints. 11. Describe the attachments, functions and innervation of the prevertebral muscles. 12. Describe the structure of the cervical part of the sympathetic trunk and the anatomical basis for the condition known as “Horner’s syndrome.” Ant. tubercle REVIEW: C1-C2 Facet for dens Ant. arch Lateral mass Transverse pr. Tubercle for transverse lig. Transverse foramen Sup. facet for occipital condyle Post. arch Post. tubercle Groove for vertebral a. ATLAS (C1): SUPERIOR VIEW Dens Sup. facet for atlas Interarticular part Inf. articular pr. Post. facet for transverse lig. Body Transverse pr. Spinous pr. AXIS (C2): POSTEROSUPERIOR VIEW 1. Atlas: a. Atlas is essentially a ring of bone, consisting of two lateral masses connected by ant. and post. arches. b. Transverse processes project further laterally than other cervical vertebrae (giving mechanical advantage to muscles that attach to it (eg., inf. oblique). Transverse foramen for passage of vertebral a. c. Ant. tubercle is for attachment of ant. longitudinal lig. and upper end of longus colli m. d. Atlas has no spine, just a post. tubercle on post. arch. e. Post. arch has groove for vertebral a. f. Lateral masses have concave, kidney-shaped facets superiorly for reception of the occipital condyles. g. Each lateral mass also has a tubercle for attachment of the transverse ligament of the atlas which runs from one lateral mass to the other. h. Anterior arch has a facet on its posterior aspect for articulation w/ the dens. 2. Axis a. Strongest of cervical vetebrae. b. Has two large, flat bearing surfaces, superior articular facets, for articulation w/the atlas above. c. Dens (odontoid process) represents body of atlas and projects superiorly to articulate with the ant. arch of the atlas. Dens also has a facet on its posterior aspect for the transverse lig. of the atlas. d. Spinous process of axis is large and bifid. 1. The joints between the sup. articular facets of the atlas and the occipital condyles are the ATLANTOOCCIPITAL (AO) JOINTS. Together the two joints act as an ELLIPSOID JOINT. They permit flexion and extension of the head, as well as lateral flexion (bending to the side). 2. There are three ATLANTOAXIAL (AA) JOINTS. The TWO LAT. AA JOINTS are between the inf. articular facets of the atlas and the sup. articular facets of the axis. These are GLIDING JOINTS. The MEDIAN AA JOINT is a PIVOT JOINT. It is formed by the articulation between the dens and the ant. arch of the atlas, and between the dens and the transverse lig. of the atlas . When one rotates the head from side to side (eg, shaking the head "no"), the skull + atlas rotate together around a central stationary pivot --- the dens. Atlas and Axis (superior view) Dens Facet for occipital condyle Facet for transverse ligament C1 C2 C3 C4 Atlanto-occipital Joints (Ellipsoid) Allow flexion/extension of head (nodding “yes”) Allow lateral flexion of head Lateral atlanto-axial joints (gliding) Median atlanto-axial joint (pivot) ROTATION OF THE HEAD OCCURS AT THE ATLANTO-AXIAL JOINTS Spinous processes and parts of vertebral arches removed: posterior view Basilar part of occipital bone Tectorial membrane Capsule of AO joint Atlas (C1) Capsule of lateral AA joint Axis (C2) Deeper (accessory part) of tectorial membrane Posterior longitudinal ligament Alar ligaments Capsule of zygopophysial joint (C2-C3) Atlas (C1) Superior longitudinal band CRUCIATE LIGAMENT Transverse ligament of atlas Inferior longitudinal band Deeper (accessory part) of tectorial membrane Axis(C2) Principal part of tectorial membrane removed: posterior view Left side of plate 1. The POST. LONGITUDINAL LIG. runs along the post. surfaces of the vertebral bodies within the vertebral canal. Its upward continuation (above the axis) is the TECTORIAL MEMBRANE. Right side of plate 2. Deep to the tectorial membrane are some imp. ligaments related to the median AA joint. The thick TRANSVERSE LIG. OF THE ATLAS holds the dens against the ant. arch of the atlas. The SUP. & INF. LONGITUDINAL FIBERS pass to the ant. margin of the f. magnum and the body of the axis (resp.). The transverse lig. + the sup. and inf. longitudinal fibers form the CRUCIFORM LIG. The strong ALAR LIGS. pass superolaterally from the dens to the med. aspects of the occipital condyles. Atlas (C1) Apical ligament of dens Alar ligament Facet of dens (for transverse lig.) Alar ligament Anterior tubercle of atlas Synovial cavities Axis (C2) Dens Cruciate ligament removed: posterior view Transverse ligament of atlas Median atlantoaxial joint: superior view ON THE LEFT SIDE OF THE PLATE note the ALAR LIGS. These ligs. are also known as "check ligs." because they function to check (restrict) the amount of rotation at the median AA joint. Rupture of an alar ligament results in an increase of ~ 30% in the range of movement to the contralateral note the TRANSVERSE LIG. OF THE ATLAS. Along with the ant. arch of the atlas, the transverse lig. forms a fibrous/bony ring surrounding the dens of the axis. This ring rotates around the dens forming a pivot joint. By keeping the dens against the ant. arch of the atlas, the transverse lig. prevents the dens from post. displacement which could damage the spinal cord. FRACTURE & DISLOCATION OF THE ATLAS (JEFFERSON OR BURST FRACTURE) Note the fractures of both the anterior and posterior arches of the atlas, and the lateral displacement of the lateral masses. A Jefferson fracture in itself does not necessarily result in spinal cord injury, b/c the dimensions of the bony ring actually increase. Spinal cord injury is more likely, however, if the transverse ligament is also ruptured. (On left) Note that the lateral masses are wedge-shaped, with the thick sides of the wedges directed laterally. Thus, vertical compressive forces (as would result from striking the bottom of a pool in a diving accident) tend to drive the lateral masses laterally (arrows), fracturing one or both of the bony arches of the atlas. If the force is great enough, the transverse ligament of the atlas will also rupture. This type of fracture is called a Jefferson (or burst) fracture. Coronal section (on right) showing direction of vertical compressive forces and lateral movement of the lateral masses of the atlas resulting in a Jefferson fracture. FRACTURE & DISLOCATION OF THE ATLAS (JEFFERSON OR BURST FRACTURE) Basilar part of occipital bone Jugular process of occipital bone Longus capitis m. (cut) Occipital condyle Rectus capitis anterior m. Rectus capitis lateralis m. Transverse process of atlas Longus capitis m. Longus colli m. 1. O ,I, F of prevertebral mm. a. Longus colli m. O – upper thoracic and lower cervical vertebrae I - cervical vertebrae (more superiorly) (reaches as high as the ant. tubercle of the atlas) F – flexes neck b. Longus capitis m. O – ant. tubercles of transverse prs. of C3 – C6 I - basilar part of occipital bone F – flexes head Basilar part of occipital bone Jugular process of occipital bone Longus capitis m. (cut) Occipital condyle Rectus capitis anterior m. Rectus capitis lateralis m. Transverse process of atlas Longus capitis m. Longus colli m. c. Rectus capitis anterior O – lateral mass of atlas I - basilar part of occipital bone F – flexes head d. Rectus capitis lateralis O - transverse process of atlas I - jugular process of occipital bone F – flexes head 2. All of the prevertebral muscles are innervated by the ventral rami of cervical nerves. LEARNING OBJECTIVES 1. Describe the functions of the pharynx. 2. Describe the different parts of the pharynx and their boundaries and relationships to each other. 3. Describe the main anatomical features seen in each part of the pharynx and their functional and clinical significance. 4. Name the layers that compose the pharyngeal wall. 5. Describe the arrangement of the muscles of the pharynx, as well as their attachments, functions and innervations. 6. Describe the mechanism of swallowing. 7. Describe the sensory innervation of the pharynx. 8. Describe the composition of the pharyngeal nerve plexus. 9. Describe the blood supply and lymphatic drainage of the pharynx. 10. Name the bony structures that form the atlanto-occipital (AO) and atlanto-axial (AA) joints and the ligaments associated with these joints. Also, describe the types of movement permitted at these joints. 11. Describe the attachments, functions and innervation of the prevertebral muscles. 12. Describe the structure of the cervical part of the sympathetic trunk and the anatomical basis for the condition known as “Horner’s syndrome.” Internal carotid n. Superior cervical ganglion External carotid a. & plexus Gray rami communicantes Middle cervical ganglion Vertebral ganglion Vertebral a. & plexus Cervicothoracic (stellate) ganglion Ansa subclavia PATIENTS WITH HORNER’S SYNDROME SYMPTOMS: 1. MIOSIS (PARALYSIS OF DILATOR PUPILLAE M.) 2. PTOSIS (PARALYSIS OF SUPERIOR TARSAL M. 3. REDNESS & INCREASED TEMPERATURE OF SKIN (VASODILATION) 4. ANHIDROSIS (SWEAT GLANDS CAN’T SECRETE)