BIRTH DEFECTS PAGE 64-67 CRITICAL PERIOD TERATOGENS THALIDOMIDE • 1957-1961--Europe • Morning sickness treatment • Leprosy treatment today (possible cancer treatment) COCAINE TOBACCO ALCOHOL • Neurodevelopmental signs associated with FAS. • • Hyperactivity • • Distractibility • • Short attention span • • Poor judgment • • Impulsivity • • Poor social skills • • Poor visual and auditory memory • • Sensory problems (vision, audition, vestibular) NUTRITION OCCUPATIONAL HAZARDS VIRAL INFECTION--ZIKA VIRUS VIRUS INFECTION CONGENITAL RUBELLA SYNDROME • 1991 unvaccinated Amish • 1999 unvaccinated immigrants in Arkansas