Standard Operating Procedure Corrected

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Akson College of Pharmacy joint Venture With Mirpur University of Science &
Technology
Ref. No: SOP/Ind/001/0
Effective Date: 26 – 11 – 18
Revision Date: 26 – 11 – 19
Standard Operating Procedure
STANDARD OPERATING PROCEDURE FOR TRAY DRYER
Department Pharmaceutics [ Industrial ]
Written by:
Reviewed by:
Approved by:
Name
Husnain Mir
Bilal Latif
Rana Irfan Hamid
Designation
Student
Student
Lecturer
Signature
1.
PURPOSE:
To establish a procedure for the maintenance and proper working of tray dryer.
2.
SCOPE:
SOP applies to the operators and workers and section in charge making use of electric tray dryer.
3.
RESPONSIBILITY:


Operators / workers to follow the procedure.
Section in charge/ Production Manager responsible to ensure the compliance with this
procedure.
4. SPECIFICATIONS:

Capacity.

Temperature control.

Blower motor.
HP

No. of trays.
08
60Kg
Thermostatic control
5. OPERATION:
The following procedure should be strictly followed before starting operation.




Before starting clean the dryer and trays properly.
Load the granulating materials in the tray and put the loaded trays in the dryer.
Adjust the inlet and outlet air by adjusting the “in” window fitted at the top of the dryer.
Adjust the temperature by adjusting the digits thermostat on the left top corner of the panel of
the dryer to the required temperature.

Adjust the time from the timer on the panel of the dryer.

Switch ON the main supply.
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Akson College of Pharmacy joint Venture With Mirpur University of Science &
Technology

ON the machine by pressing the Green Push Button. The air blower will start.

Then ON the heaters from the ON/OFF button fitted on the main panel of the dryer pressing
the Red Push Button.

Switch OFF the main supply.
6. CLEANING:
At the end of each operations ash the trays with hot water and clean all others parts with damp
cloth and then properly dry it.
7. PRECAUTIONS.
 “ON” the blower and heater and leave it open for few minutes and then close the dryer.
 Check the temperature after every 15 minutes and record the on BMR.
 When granulation is done with organic solvent, the temperature should not exceed 40C.
 When aqueous solvent is used then dry up to 45C.
 The door of the dryer will be remain slightly open for the first 5 minutes if organic solvent is
used in granulation.
8.
RECORD:
 Log book for electric tray dryer.

The outlet air temperature reaches a pre-selected value corresponding to the moisture required
in the final product cycle will be terminated.

Set the inlet air controlled to the maximum safe working temperature for the material, which
is to be dried at 10-50C.

Set the timer to the required time.
9. PROCEDURE:
 Charge the material into the product container and spread to form a layer of even thickness.
 Wheel the product container into the cabinet pushing the container as far back as possible and
the wind trolley handle in clockwise direction, until the container rim becomes pressed firmly
against the rubber gasket.
 Close the cabinet door.
 Close the air control damper.
 Depress the process timer present button.
 Alternate the air damper several times between the open and closed position, this cause air
slug to through the bed and break down the agglomerated material. Set the damper lever to the
position, which gives the desired turbulence to the bed.
 The drying cycle will be terminated when either the set drying period has elapsed or the outer
temperature reaches the preset value.
 Operate the filter bag shaker, open the cabinet door lower the container and withdraw it from
the cabinet.
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Akson College of Pharmacy joint Venture With Mirpur University of Science &
Technology
10. CHECK POINTS:
 At the start of the day, run preheat the dryer by warming up for about 5 minutes.
 The inlet air filters should be examined periodically and remove for washing when necessary.
 The base of the container should be kept cleaned, particular attention should be paid to the
diffusion holes. Any blockage should be blown or washed away.
 Before removing the container at the end of drying cycle, shake the filter bag and allow any
dust to settle.
11. RELATED RECORDS:
Copy No.
Copy To
Recipients Sign &
Q.C Sign & Date on
Date
Retrieval
1
Q.A Manager’s Copy
2
Q.C Manager’s Copy
3
Director’s Copy
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Akson College of Pharmacy joint Venture With Mirpur University of Science &
Technology
AMENDMENT HISTORY
Sr. No Date
Initiated
By
Page
No.
Nature of Amendment
Page 4 of 4
Done
By
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