Course no. MF9130E
Introductory Course in Statistics
6. – 9. and 20. – 23. September 2010
Literature:
It is recommended to buy one of the following two books:
• B. R. Kirkwood and J. A. C. Sterne: Essential medical statistics, 2nd ed. Blackwell, 2003.
• In Norwegian: O. O. Aalen et al: Statistiske metoder i medisin og helsefag. Gyldendal, 2006.
Teaching facilities:
Rooms are either in Domus Medica (DM) or Domus Odontologica (DO), Sognsvannveien 9.
Two PC-labs are used, one in the basement (underetasje), and one next to the bookstore
Akademika.
Teachers:
Professor Odd O. Aalen, Department of Biostatistics, IMB (Course leader)
Associate professor Birgitte Freiesleben de Blasio, Department of Biostatistics, IMB
Associate professor Bettina Kulle Andreassen, Epi-gen, Ahus, UiO
Research fellow Jon Michael Gran, Department of Biostatistics, IMB
Research fellow Nina Gunnes, Norwegian Institute of Public Health
Postdoc Kjetil Røysland, Department of Biostatistics, IMB
Monday 6. September:
08.30-09.00: Registration. (Outside Lille Auditorium in Domus Medica)
09.00-11.45: Data and descriptive statistics. (Auditorium A1.1001 DO). (Aalen).
Literature: Aalen chap. 1 og 2, Kirkwood and Sterne chap. 3 and 4
11.45-12.30: Lunch break
12.30-13.45: Exercises: Introduction to SPSS. (PC-lab basement DM).
Exercises: 1 and 2 in the exercise booklet (Røysland, Aalen)
14.00-15.45: Basic concepts of probability. (Auditorium A1.1001 DO). (Røysland).
Literature: Aalen chap. 3.1-3.7. Kirkwood and Sterne chap. 14
Tuesday 7. September:
08.30-09.15: Bayes law. Sensitivity, specificity. (Auditorium A1.1001 DO). (Aalen).
Literature: Aalen chap. 3.9 and 3.10, Kirkwood and Sterne chap. 36.2
09.30-11.00: Binomial distribution. (Auditorium A1.1001 DO). (Aalen).
Literature: Aalen chap. 4, Kirkwood and Sterne section 15.1 and 15.2
11.15-12.15: Exercises: 9 and 12 in the exercise booklet. (A1.1001 DO). (Aalen)
12.15-13.15: Lunch break
13.15-14.00: The normal distribution. (Auditorium A1.1001 DO). (Røysland).
Literature: Aalen chap. 5, Kirkwood and Sterne chap. 5
14.15-15.00: Exercises. Exercise 14 in the exercise booklet.
(Auditorium A1.1001 DO). (Røysland)
15.15-15.45: Joint discussion of exercises. (Auditorium A1.1001 DO). (Røysland)
Wednesday 8. September:
08.30-10.45: Introduction to hypothesis testing and confidence intervals. One-sample
Student’s test and conf. interval. (Lille auditorium DM). (Andreassen).
Literature: Aalen chap. 8.1-8.5, Kirkwood and Sterne chap. 4, 6 and 7
11.00-12.00: Exercises. Exercise 13 in the exercise booklet. (PC-lab 2nd floor DM). (Andreassen)
12.00-12.45: Lunch break
12.45-14.15: Two-sample Student’s test and confidence interval. (Auditorium A1.1001 DO).
(Andreassen). Literature: Aalen chap. 8.6 og 8.7, Kirkwood and Sterne chap. 7
14.15-15.45: Exercises. Exercise 15 in the exercise booklet. (PC-lab basement DM).
(Andreassen).
Thursday 9. September:
08.30-11.15: Transformations. Non-parametric methods. (Auditorium A1.1001 DO). (Aalen).
Literature: Aalen chap. 8.8, Kirkwood and Sterne chap. 13 and 30.2
11.15-12.15: Exercises. Altman 9.2 and 9.4 and exercise 4 (all in the booklet). (PC-lab 2nd floor
DM). (Gran, Aalen)
12.15-13.00: Lunch break
13.00-14.30: Regression analysis, correlation. (Auditorium A1.1001 DO). (Aalen).
Literature: Aalen chap. 11.1-11.3, Kirkwood and Sterne chap. 10
14.45-15.45: Exercises. (PC-lab 2nd floor DM). (Gran, Aalen). 3 and 7 in the exercise booklet
_________________
Exercises for the intervening period:
You should read through the material from the first period and do the following exercises:
8, 10 and 11 in the exercise booklet
We shall go through the exercises at the beginning of the next period.
_________________
Monday 20. September:
08.30-09.30: Discussion of the exercises from the intervening period. (Seminarrom 1128 DM).
(Aalen)
09.45-11.15: Regression analysis cont., multiple regression. (Seminarrom 1128 DM). (Aalen).
Literature: Aalen chap. 11.4-11.6, Kirkwood and Sterne chap. 11 and 12
11.30-12.30: Exercises. (PC-lab 2nd floor DM). (Gran, Aalen).
Exercises: Altman 11.2 + 18 in exercise booklet.
12.30-13.15: Lunch break
13.15-15.00: Some more about regression. Confounding. Interaction. (Lille auditorium DM).
(Aalen). Literature: Kirkwood and Sterne chap. 38
Tuesday 21. September:
08.30-10.15: Statistical analysis of proportions. Odds ratio, relative risk etc.
(Seminarrom 1128 DM). (Gunnes).
Literature: Aalen chap. 6.1-6.4, Kirkwood and Sterne chap. 15 and 16
10.30-11.30: Exercises. (Lille auditorium DM). (Gunnes).
Exercises 16 and 17 in the booklet
11.30-12.00: Discussion of exercises
12.00-12.45: Lunch break
12.45-14.15: Analyzing tables (chi squared, exact and Monte Carlo tests). (Lille auditorium
DM). (Gunnes). Literature: Aalen chap. 6.5, Kirkwood and Sterne chap. 17
14.30-15.30: Exercises. (PC-lab 2nd floor DM). (Gunnes)
Exercises: Altman 10.1a, 10.3, 10.7 (see Exercise booklet).
Wednesday 22. September:
08.30-09.30: Epidemiologic design and basic concepts. (Lille auditorium DM). (Aalen)
09.45-11.30: Principles for organizing clinical trials. (Lille auditorium DM). (Aalen).
Literature: Aalen chap. 9 og 10, Kirkwood and Sterne chap. 32 and 34
11.30-12.15: Lunch break
12.15-14.00: Sample size and power. (Lille auditorium DM). (de Blasio).
Literature: Aalen chap. 9.6, Kirkwood and Sterne kap. 35
14.15-15.45: Exercises. (Lille auditorium DM). (de Blasio, Aalen)
Exercise 19, 20 and/or 21 from booklet
Group rooms: 2227b, 2228c, 2239, 2141 DM
Thursday 23. September:
08.30-10.45: Event history analysis. (Seminarrom 1128 DM). (Aalen).
Literature: Aalen chap. 13, Kirkwood and Sterne chap. 26
11.00-12.15: Exercises. (PC-lab 2nd floor DM). (Gran, Aalen)
Exercises 5 and 6 from booklet
12.15-13.00: Lunch break
13.00-14.00: Limitations of statistics. Causality. (Lille auditorium DM). (Aalen).
Literature: Aalen chap. 14.
14.00-14.45: Summary. (Lille auditorium DM). (Aalen)
Course exam:
A take home exam will be handed out at the end of the course. This should be solved at home and
then returned within a specified deadline.