Annual Report 2012- 2013
Board of Radiation and Isotope Technology
Executive Summary
Radiation Technologies & Applications
Board of Radiation & Isotope Technology (BRIT) supplies a vast array of high quality
radioisotope products for medical and industrial use. Setting up of radiation processing
plants in private sector is one of the important activities along with isotope application
services.
Iodine-131 capsule production Hot Cell
Healthcare
More than 60000 cold kits for formulation of 99mTc radiopharmaceuticals (code-TCK: 11
Products) were supplied to various Nuclear Medicine Centers.
200 Ci of 99Mo (TCM-2) for solvent extraction and around 200 Ci of Mo-99 as alumina
column generator (New product-COLTECH) and Gel Generators were supplied to
hospitals.
20000 Consignments of ready to use radiopharmaceuticals of 131I , 32P, 51Cr and 153Sm
were supplied. 131I radiopharmaceuticals amounted to about 530 Ci in over 17000
consignments. The frequency of production and supply of injectable products 153SmEDTMP and 131I MIBG has increased.
Two new products 99Mo-99mTc alumina column generator (Brand name “COLTECH”)
and ready to use radiopharmaceutical Colloidal Samarium Phosphate 32P (SMPC) Code
PHM-4 have been launched.
The commissioning of the column generator production facility at BRIT and availability of
generator “COLTECH” has made a great impact on the market. The prices of the similar
capacity imported products have dropped considerably. With approval to full capacity
BRIT will be able to cater to large number of nuclear medicine centres.
1
The introduction of colloidal Samarium [32P] Phosphate as a therapeutic
radiopharmaceutical for radiation synovectomy has filled a major requirement in the
treatment plan of hospitals across the country. The radiopharmaceutical brings relief to
patients suffering from haemophilic arthropathy, rheumatoid arthritis,and osteoarthritis.
BRIT has thus provided an indigenous alternative at economical prices to hospitals
requiring this radiopharmaceutical.
A new facility for production of high activity I-131 capsules has been set up at BRIT
Complex. AERB has given approval for limited production runs. The new facility will
enable BRIT to enhance the volume of I-131 capsules production and also manufacture
capsules containing higher ( > 25 mCi) I-131 radioactivity for the treatment of thyroid
cancer
A total number of about 7000 radioimmunoassay (RIA) and immunoradiometric assay
(IRMA) kits were produced and supplied. RIA Laboratory has achieved UKAS (United
Kingdom Accreditation Services) accreditation and International Quality Standards ISO
9001:2008 and ISO 13485:2003 certification.
IRMA procedure and prototype kit for human C-peptide was designed and is currently
being evaluated for its performance.
Regional Center Delhi supplied ~ 52,000 mCi of various ready-to-use 99mTc
Radiopharmaceuticals in Delhi. Retail outlet for radiopharmaceuticals (ROR) Delhi
supplied 1300 cold kits valued at Rs. 30 lakh.
Regional centre, Bangalore supplied 72000 mCi of ready-to-use 99mTc formulations.
Around 600 TCK cold kits were sold through retail outlet for radiopharmaceuticals. 1700
Blood bags were irradiated using BI 2000.
Regional Centre of BRIT at Kolkata was engaged in 99mTc production through 100Mo
(p,2n) reaction in the cyclotron. The purified 99mTc was suitable for preparation of 99mTcradiopharmaceuticals. This work was carried under the IAEA CRP.
99m
Tc-HYNIC-HIS3-TATE was prepared using Fmoc solid-phase peptide synthesis for
developing 99mTc-radiopharmaceuticals for imaging somatostatin receptor-positive
tumors. This work was done in collaboration with IICB, Jadavpur, Kolkata.
Retail outlet for cold kits for radiopharmaceuticals at RC, Kolkata was inaugurated in
October 2012.
The Regional Centre Dibrugarh located at Assam Medical College & Hospital rendered
the RIA and IRMA diagnostic services for the benefit of patients of the entire northeastern region
At Labelled Compounds laboratory tritium filled light sources of various types for defence
applications were produced and met the desired requirements in military gadgets and
instruments 40 nos of indigenously prepared 14C-urea breath cards were provided to
RMC, Parel for quality evaluation.
2
Regional Centre Hyderabad developed a gel based PCR diagnostic kit for detection of M
tuberculosis in collaboration with RMC, BARC, Mumbai.
A total of 1508 consignments of 32P nucleotides, 32P orthophosphoric acid, 35S amino
acids. radiopharmaceuticals cold kits (TCK products) were supplied and earned Rs. 208
Lakh.
Radioanalytical laboratory carried out ~4000 tests on export commodities and 670 tests
on domestic water samples (gross alpha, gross beta 226Ra & 228Ra). Around 5800 water
samples were received from Punjab for the assay of uranium content.
Setting up of new Radioanalytical Laboratory at Regional Centre, Bangalore and BRIT
Project House, Deonar is in progress.
Quality Control Monographs for 17 products for incorporation in Indian Pharmacopeia
were prepared and submitted to RPC for approval.
Batch records of TCK products were documented. Digitization of all the batch records is
in progress. QA implementation in ready to use radiopharmaceuticals has been initiated
with IOM-1.
Five numbers of cobalt-60 teletherapy sources were supplied to different hospital with
total activity 58 and 200 RMM. 172 kCi of high specific activity Cobalt-60 for the
fabrication of Cobalt Teletherapy sources is imported from M/s Reviss, UK.
100 cm of ( Ir-192 + Pt Wire) with total activity of 644.67 mCi were supplied for various
brachytherapy applications.
Industrial Applications
Irradiator sources of total of 1300 kCi activity were supplied to NIPRO, Satara, JPCL,
Bhiwadi, UML Vadodara, and AVPP Ltd., Ambernath. ISOMED, Trombay was loaded
with additional 78 kCi and RPP, Vashi received 200 kCi of cobalt-60 activity. Install and
Operate Irradiator is to be loaded with 50 kCi of Cobalt-60 activity
900 Ir-192 Radiography Sources with a total activity of 40 kCi, 7 Co-60 Radiography
Sources with a total activity of 400 Ci and 1 Tm-170 radiography source with 10 Ci
activity were fabricated and supplied to various NDT users in the country.
Radiation Sources of Co-60, Cs-137 and Tm-170 for Nucleonic Gauges and other
various applications were made.
15 Numbers of GC-4000 pencils unloaded from GC-4000 unit supplied to Urugway have
been brought to India , The sources were brought from USA in two numbers of Type A
lead pots. Both the packages were sent back to USA after removal of sources.
Five Blood Irradiators (BI 2000) were loaded with approx. 808 Ci of
Another 27 sources are ready for loading in three BI 200 units.
60
Co-Cobalt activity.
3
First Radiometry of Install and irradiate operator was carried out and hot spots were
detected. Next radiometry is planned after the repaired unit is received at HIRUP.
3 Ci Ir-192 HDR source was fabricated for the indigenous HDR unit for the first time The
newly installed 3 port laser system is being used for the radiometry of the HDR transport
flasks.
A total Cobalt-60 activity of 861 kCi in 17 sub assemblies was processed at regional
center, RAPPCOF, KOTA. 1170 kCi of activity was transported in 12 consignments. 15
numbers of W-91 sources were fabricated at RAPPCOF. Two teams of RAPPCOF has
carried out source loadings at OGFL and JCPL, Bhiwadi successfully.
82488 no of boxes were processed at ISOMED earning a revenue of ~ Rs. 290 lakhs.
The average plant utilization factor was around 96% and there was 100% load
availability of healthcare products at ISOMED. The source strength has been augmented
to 400 kCis
RPP Vashi processed about 2733 MT of spices and other products were processed till
December 2012. Revenue generation till December 2012 is about 195.67 lakhs. Source
replenishment was carried out to enhance source strength from 400 kCi to 600 kCi. to
cope up with the increased demand for radiation processing.
Facility of e-payment has been provided to customers for payment of processing
charges.
MoU signed with M/s Divyakiran for Radiation Processing Plant at Anand, Gujarat
Two Radiation Processing Plants namely, M/s Hindustan Agro Co-Operative Ltd.,
Rahuri, Maharashtra with source loading of 65 kCi and M/s Nipro India Corporation Pvt.
Ltd, Pune with source loading of 275 kCi were commissioned.
BRIT has been, for nearly a decade, working closely with customers to launch radiation
processing plants all over the country. The tenth plant in private sector was
4
commissioned this year at Pune- Satara Road by NIPRO Corporation Pvt. Ltd. for
sterilization of dialysis units manufactured by them. Using the 5 Mega curie Co-60
radiation processing facility NIPRO would be exporting the sterilized dialysis units
worldwide.
Mou was signed with M/s Isorad Tech Pvt Ltd, Chennai, M/s Divyakiran Agro Processing
Pvt. Ltd, Anand, Gujarat and M/s Radura Irradiators, Nashik, Maharashtra for setting up
of Radiation Processing plant.
A crosslinked polymer blend material (LDPE and EVA) for moldable electrical insulation
components meeting IEC standards were developed using 2 MeV electron beam ILU-6
EB accelerator.
Gamma Chamber GC 1200 supplied and installed at National Botanical Research
Institute, Lucknow. A Low dose Irradiator has been supplied and installed at INMAS,
New Delhi.
A GC 5000 unit is kept ready for export to Bangladesh Institute of Nuclear Agriculture is
expected to be dispatched early in this year.
A new source extraction tool has been developed for removing and transferring the
decayed source from Gamma Chambers to type B(U) packages. .
Three Blood Irradiator 2000 units (BI 2000) were supplied and installed at Rajeev
Gandhi Cancer Institute, Delhi, Surat Raktadan Kendra, Surat and Apollo Hospital,
Hyderabad.
A new radiography camera model ROLI-2 was introduced in November 2012. BRIT
supplied 58 radiography exposure devices, 371 ROLI cameras were serviced and 789
decayed sources were removed. 581 imported cameras were inspected
Install and irradiate operator has been installed and functional test has been carried out
successfully. It is now being planned for source loading and radiometry.
ROLI 1 cameras were tested at the REPF workshop and the Radiological lab of BARC.
Density measurements were carried out on cobalt-59 pellets and slugs and also
chemical analysis and XRF analysis were carried out for the acceptance of the material
for irradiation.
Radiotracer technique was used for leak detection in series of heat exchangers at
Chennai Petroleum Corporation Limited (CPCL), Chennai and Bharat Petroleum
Corporation Limited (BPCL), Mumbai. On-line radioisotope techniques using 82Br as
radiotracer, the leaky heat exchangers could be exactly identified saving them huge
downtime losses.
Gamma scanning of process columns were carried out in various refineries and
chemical industries for troubleshooting. The gamma scanning of process columns was
carried out by using sealed source 60Co.
5
The transportation of about 48524 consignments of radioisotope and allied products,
majority of them by air was carried out in a safe manner.
Eight fabrication work orders were executed for BC188 type source transportation cages
(each carries nearly 100-125 KCi Cobalt) to supply the source to domestic and
international Irradiators.
BRIT website provided an updated information irway bill numbers for the despatched
products and on receipt, inspection and ready for despatch status of radiography
cameras on weekly basis.
The work on ambitious Fission Molybdenum Project for setting up of a State-of-the Art
GMP compliant facility capable of producing 300 Ci per week 99Mo is in progress. The
construction of new building has commenced at the approved site near the ISOMED
Complex at south site of BARC.
The completion of this project will let BRIT take off to larger scales of production of 99Mo
-99mTc column generator Kits in the Indian market. Kits with larger quantity available at
the radiopharmacy level and uninterrupted distribution will enable BRIT to deepen the
existing demand for kits as well as enlarge the customer base to include new Nuclear
Medicine centers opening in the non-metro towns of India. With global shortage of 99mTc
kits looming in the world market, BRIT will act as a major provider of the kit in times to
come.
Radioisotopes and allied products supplied by BRIT
Sr.No
Item
1
2
3
Consignments
Activity
Sale Value
Actual between
April-December, 2012
50000
1000 kilo curies
Rs. 5000 lakhs
Expected to be achieved
April, 2012 – March, 2013
~ 60000
~ 1500 kilo curies
~ Rs. 7000 lakhs
6
Annual Report 2012- 2013
Board of Radiation and Isotope Technology
Descriptive Part
CH 4 Radiation Technologies & Applications
Board of Radiation & Isotope Technology (BRIT) is a commercial unit of the Department
of Atomic Energy which significantly contributes to the much varied needs of
radioisotopes and radiation sources in the country. The applications of radiation and
radioisotopes in science, medicine, agriculture, research and technology play a
prominent part in the progress of mankind. BRIT has a mandate to fulfill this role by
regular production and supply of a vast array of high quality radioisotope products and
radiation sources.
The major beneficiaries of the growth of BRIT as a national organization include
healthcare, industry, research and agriculture. Sterilization of medical products,
radioisotope labelled pharmaceuticals, 99mTc column generators, equipment and
radiography sources for non-destructive radiographic devices are some of the major
areas of BRIT’s operations. The application of isotopes for leak detection in various
industrial processes is another significant contribution from BRIT. The medical cyclotron
facility produces 18F labeled radiopharmaceuticals for many PET (Positron Emission
Tomography) examinations. PET is considered as a major breakthrough in nuclear
medicine after 99mTc radiopharmaceuticals. BRIT is engaged in setting up of a fission
molybdenum production facility that would be operational in another two to three years
time and provide a huge boost to its 99mTc Column Generator technology.
BRIT is promoting setting up of radiation processing plants in the private sector for food
and sterilization of Medical products. As a major element of the perspective plans of the
department and as a program which has tremendous spin-off benefits to the society at
large, the adoption of radiation processing as a sustainable business by private industry
augurs well for the future. BRIT has been, for nearly a decade, working closely with
customers to launch radiation processing plants all over the country. The tenth plant in
private sector was commissioned this year at Pune- Satara Road by NIPRO Corporation
Pvt. Ltd. for sterilization of dialysis units manufactured by them. Using the 5 Mega curie
Co-60 facility NIPRO would be exporting the dialysis units worldwide . Development of
many other new irradiators is also in progress.
Radiation technology equipments such as blood irradiators, gamma chambers and low
dose irradiators provide a valuable research tool for studying the effects of radiation in
materials which find applications in medicine, agriculture and polymer industry.
Applications of radioimmunoassays and immunoradiometric assays find diagnostic value
in many disease conditions especially the thyroid related disorders. The availability of
14
C and tritium labeled compounds as tracers and the 32P and 35S labeled biomolecules
have played a definitive role in molecular biology and agricultural research. Tritiated
fluorescent sources find use in various defense applications. Several technetium ‘cold’
kits’ used in the preparation of 99mTc radiopharmaceuticals are also supplied by BRIT.
1
As a service provider, BRIT also operates plants for radiation sterilization of medical
products (ISOMED) at Trombay; Radiation Processing Plant at BRIT Vashi Complex for
radiation processing of spices and allied products, and runs Co-60 handling facility
(RAPPCOF) at RAPS, Kota, JONAKI Laboratory at Hyderabad and has other Regional
Centres located at Bangalore, Delhi, Kolkata and Dibrugarh. BRIT runs a Radioanalytical Laboratory at Vashi for detection of radioactivity in products for the benefit of
various exporters and importers.
Iodine-131 capsule production Hot Cell
The various activities carried out by BRIT related to the production and supply of
radioisotopes and allied products and radiation technology equipment for use in
Healthcare, Industry, Agriculture and Research during the period of this report are as
follows:
4.5
Healthcare
4.5.1. Radiopharmaceuticals
More than 60,000 cold kits for formulation of 99mTc radiopharmaceuticals (11 products
under the code of TCK) were supplied to various nuclear medicine centers. 200 Ci of
99
Mo (TCM-2) for solvent extraction and around 200 Ci of Mo-99 as alumina column
generator (New product-COLTECH) and Gel Generators were supplied to hospitals for
separation of 99mTc. In addition to this various accessories of 99mTc Generator systems
and other products were supplied. Nearly 20,000 Consignments of ready to use
radiopharmaceuticals of 131I , 32P, 51Cr and 153Sm were supplied to various Nuclear
2
Medicine Centers. Majority of these contained 131I radiopharmaceuticals, which
amounted to about 530 Ci in over 17000 consignments. There has been a considerable
reduction in the import of radioisotopes because of the local availability of the raw
material radioisotopes from the reactor whose performance has been good. The
production and supply of 32P as sodium orthophosphate was mainly due to nonavailability of quality 32P radioisotope. The frequency of production and supply of
injectable products 153Sm-EDTMP and 131I MIBG has increased during the year 2012-13.
Two new products 99Mo-99mTc alumina column generator (Brand name “COLTECH”)
and ready to use radiopharmaceutical Colloidal Samarium [32P] Phosphate (SMPC)
Code PHM-4 have been launched this year successfully.
At present low specific activity Mo-99 is available from reactors at BARC. This Mo-99 is
being supplied to nuclear medicine centers over the country and is being used with
solvent extraction generators for elution of Tc-99m for labeling with cold kits for medical
imaging. Solvent extraction is a lengthy and operator dependent procedure which is not
preferred by the users.
The commissioning of the column generator production facility at BRIT and availability of
generator “COLTECH” has made a great impact on the market. The prices of the same
capacity imported products have dropped considerably. At present the capacity of
BRIT’s COLTECH generator production facility is limited due to initial approval of upto
20 Ci of 99Mo-99 from AERB. With approval to full capacity BRIT will be able to cater to
large number of nuclear medicine centres.
The introduction of colloidal Samarium [32P] Phosphate as a therapeutic
radiopharmaceutical for radiation synovectomy has filled a major requirement in the
treatment plan of hospitals across the country. The radiopharmaceutical brings relief to
patients suffering from haemophilic arthropathy, rheumatoid arthritis,and osteoarthritis.
Sterile pyrogen free, white colloidal solution is now being supplied as an injection for
administration by intraarticular instillation. It has no systemic leakage from the joints and
has no adverse effects. BRIT has thus provided an indigenous alternative at economical
prices to hospitals requiring this radiopharmaceutical.
3
99m
Tc - Coltech Generator
A new facility for production of I-131 capsules consisting of shielded mini hot cell and
fume hoods has been set up at BRIT Complex. It has better shielding features through
remote operations in customized cell gadgets. The leak tight hotcells also ensure better
performance compared to the existing facility. AERB has given approval for limited
production runs. The new facility will enable BRIT to enhance the volume of I-131
capsules production and also manufacture capsules containing higher ( > 25 mCi) I-131
radioactivity for the treatment of thyroid cancer. Presently BRIT has been mainly
supplying these radiopharmaceuticals in liquid doses.
4
Radiopharmaceutical Production Facility
4.5.2 Nuclear Medicine : Diagnostic & Treatment Service
A total number of about 7000 radioimmunoassay (RIA) and immunoradiometric assay
(IRMA) kits were produced and supplied to various hospitals, research centres and
immunoassay laboratories in India.
RIA Laboratory at BRIT Vashi Complex has achieved UKAS (United Kingdom
Accreditation Services) accreditation and International Quality Standards ISO 9001:2008
and ISO 13485:2003 certification. Quality systems implemented by RIA laboratory were
rigorously assessed by one of the leading ISO certification agency URS Certification
Limited on recommendation of UKAS in December 2012.
A contract research service pertaining to Chromium Release Assay was undertaken and
successfully executed for Jai Research Foundation (JRF), Valvada, Gujarat. About 600
samples were analyzed for immunotoxicity studies using chromium release assay using
in-house 51Cr. The work was jointly carried out at BRIT Vashi Complex and JRF,
Valvada facilities.
Development of IRMA procedure for human C-peptide was initiated last year is being
continued. A prototype kit was designed and is currently being evaluated for its
performance.
Regional Center, Delhi was involved in the production and supply of around 52,000 mCi
of various ready-to-use 99mTc Radiopharmaceuticals injections in compliance with GMP
and RPC for diagnostic nuclear medicine studies in 21 hospitals in Delhi and NCR. The
value of supplied 99mTc Radiopharmaceuticals is estimated to be Rs. 23.50 lakh.
Retail outlet for radiopharmaceuticals (ROR) Delhi supplied 1300 cold kits for
preparation of various 99mTc Radiopharmaceuticals valued at Rs. 32.5 lakh.
Developmental work on 99mTc alendronate as an alternative bone imaging agent and
reinduction of 99mTc- Ciprofloxacin is in progress. A renovated class 10000 laboratory for
production of radiopharmaceuticals and labeled compounds is nearly complete.
Regional centre, Bangalore supplied 72000 mCi of ready-to-use 99mTc formulations.
Around 600 TCK cold kits were sold through retail outlet for radiopharmaceuticals. 1700
Blood bags were irradiated using BI 2000. 600 consignments were collected by the
Bangalore centre on behalf of several nuclear medicine customers in the Bangalore
region.
Regional Centre of BRIT at Kolkata works in close collaboration with
Radiopharmaceutical section, BARC, VECC, Kolkata and Indian Institute of Chemical
Biology (IICB), Jadavpur.
Natural Mo foil stacks (25-100 micron thick) were irradiated at 15-18 MeV proton for 5
min, 1 h, 3 h and 6 h to study 99mTc production through 100Mo (p,2n) reaction in the
cyclotron. If enriched 100Mo target is irradiated at 15.6 MeV with 200 µA proton beam
extracted 99mTc activity at the end of 6h bombardment would be ~7.5 Ci. Overall yield of
5
99m
Tc was about 80%. After quality assessment the purified 99mTc was found to be
suitable for preparation of 99mTc-radiopharmaceuticals. This work was carried under the
IAEA CRP.
68
Ge-68Ga generator - 68Ge was produced by internal irradiation of natural zinc target
using an α beam of variable energy cyclotron. 68Ge production yield was 0.86 μCi/ μAh.
The suitability of 68Ga was assessed by labeling EDTMP with it. The radiochemical purity
of the labeled 68Ga-EDTMP was about 95%.
99m
Tc-HYNIC-HIS3-TATE – octreotide analogs of peptides find increased interest in
nuclear oncology for targeted tumor diagnosis and therapy. New cyclic octapeptides
conjugated with HYNIC were prepared using Fmoc solid-phase peptide synthesis. The
purified analogs were labeled with 99mTc using Tricine and EDDA. Bio-distribution and
image studies showed very high uptake in kidney. These can be useful for developing
99m
Tc-radiopharmaceuticals for imaging somatostatin receptor-positive tumors. This
work was done in collaboration with IICB, Jadavpur, Kolkata.
Retail outlet for cold kits for radiopharmaceuticals at RC, Kolkata was inaugurated in
October 2012. Nuclear medicine centers in and around the city are likely to benefit of
directly obtaining the cold kits from ROR.
The Regional Centre Dibrugarh located at Assam Medical College & Hospital rendered
the RIA and IRMA diagnostic services for the benefit of patients of the entire northeastern region. More than 10,000 patients availed the services offered by this centre for
analysis of hormones like T3, T4, TSH, LH, FSH, PRL, beta- HCG, Ferritin and insulin.
4.3.2 Nuclear & Biotechnological Tools
4.3.2.1 Labelled Compounds
Labelled Compounds Programme of BRIT is involved in the synthesis and supply of a
variety of 14C, 3H and 35S-labelled products, which are powerful and versatile tools and
are used as radiotracers in diverse investigations in the fields of biology, agriculture,
medicine and chemistry.
The production and supply of tritium filled light sources of various types for defence
applications met the desired requirements in military gadgets and instruments. Customsynthesis of a few compounds were carried out for some R&D organizations. Carbon-14
labelling of Tulsi and Brahmi plants were carried out using 14C- urea for a DST project
sanctioned to Haffkine Institute of Research, Training & Testing, Mumbai
6
Labelling tulsi with 14C- urea for Haffkine Research Institute
Details of the products dispatched during the year 2012 -13 is given below.
Sl.No.
1.
2.
3.
4.
5.
6.
7.
Product Category
14
C-products
H-products
35
S-products
Custom synthesis/TLS
TFS &TTS (Tritium Sources)
14
C-urea capsules
Taq DNA Polymerase
3
Total No. of Consignments*
11
19
60
nil
16 (4647 nos)
05 (480 nos)
01 (2 lakh units)
* figure up to December 2012
Highlights
7
1. Custom synthesis of 14C-radiolabelled Ammonium thiocyanate (500 mCi).
2. Production and supply of large number of Tritium-filled self-luminous sources to
various defence establishments.
3. 40 nos of indigenously prepared 14C-urea breath cards were provided to RMC,
Parel for quality evaluation.
4.3.2.2 JONAKI Laboratory at CCMB Campus, Hyderabad
Jonaki, Radioisotope Labelled Biomolecules Laboratory of BRIT at CCMB Campus is
primarily involved in the production and supply of 32P labeled nucleotides and also a few
molecular Biology kits and enzymes required for Molecular Biology, Biotechnology and
Biomedical and drug discovery research of the country. It also markets a few products
produced at BRIT Mumbai facility like 35S labeled amino acids products, and through its
retail outlet supplies BRIT 99mTc cold kits (TCK) to the nuclear medicine centres of
Andhra Pradesh.
The laboratory has a well defined molecular diagnostic programme. A gel based PCR
diagnostic kit for detection of M tuberculosis was developed in collaboration with RMC,
BARC, Mumbai. The kit is now being supplied regularly. Real time PCR based M
tuberculosis detection kit developed at Jonaki will shortly go for evaluation on clinical
samples. This kit is based on a patented chemistry developed at Jonaki and is likely to
be a good substitution for imported kits. Additional Real time PCR kits for determination
of load of viruses like Hepatitis B and C, and a few cancer markers like EGFR, BCR-ABL
are in the process of development. Further, a thorough validation of the Real time PCR
chemistry developed here is also approaching completion.
A total of 1508 consignments were supplied. These comprised mainly 32P nucleotides,
32
P orthophosphoric acid, 35S amino acids, LCK Kits, Taq Polymerase and PCR Product,
radiopharmaceuticals cold kits (TCK products). The revenue earned was Rs. 208 Lacs.
4.3.2.3 Radio-Analytical Laboratory, Vashi Complex, Navi Mumbai
Radioanalytical Laboratory at Vashi is engaged in the measurement and certification of
residual radioactivity in commodities such as food samples, animal feed supplements,
steel, water and soil samples and other miscellaneous items. Generally, food items are
monitored for the presence of 137Cs & 134Cs. Water samples are routinely analysed for
gross alpha/gross beta, uranium, 226Ra and 228Ra content, depending upon the
requirement. BRIT also carried out 12 survey for certification of surface radiation dose of
steel consignments.
RAL has carried out more than 4000 tests on export commodities and 670 tests on
domestic water samples (gross alpha, gross beta 226Ra & 228Ra) . During the year,
5772 water samples were received from Punjab State for the assay of uranium content.
These figures are for the period upto December 2012.
In addition to above, 198 samples imported from Japan, were also received for
radioactivity assay and certification.
Setting up of Radioanalytical laboratory at BRIT Regional Centre, Bangalore is
completed and AERB accreditation procedure is in progress.
8
BRIT has also initiated work related to setting up of Radioanalytical laboratories at BRIT
Project House, Deonar and also at BRIT Regional Centre, Hyderabad.
Quality Control Program
QCP is responsible for the analysis of various ready-to-use radiopharmaceuticals,
Technetium cold kits, certifying the product for release of QC reports. Quality Control
Monographs for 17 products for incorporation in Indian Pharmacopeia were prepared
and submitted to RPC for approval. HPLC analysis of some of the radiopharmaceuticals
were standardized. Bio-distribution studies for 153Sm-EDTMP injection has been
discontinued as well as the use of column chromatography procedure as an alternate
method for RCP has been implemented after getting the approval from RPC.
Quality Assurance
Batch records of TCK products were documented. Digitization of all the batch records is
in progress. QA implementation in ready to use radiopharmaceuticals has been initiated
with IOM-1. Calibration work was performed on radiation counters with C& I group.
4.5.3. Nuclear Medicine: Cancer Diagnostic & Treatment Services
Co-60 Teletherapy Sources : Five numbers of teletherapy sources were supplied to
different hospital with total activity 58 and 200 RMM. Another Nine sources are ready for
supply. 11 numbers of decayed sources were unloaded from the teletherapy units and
stored for fabrication of irradiator source.
172 kCi of high specific activity Cobalt-60 for the fabrication of Cobalt Teletherapy
sources is imported from M/s Reviss.
Coblat-60 flask for Cobalt teletherapy Source
9
Brachythearpy Applications : 100 cm of ( Ir-192 + Pt Wire) with total activity of 644.67
mCi were supplied for various brachytherapy applications.
Industrial Applications
4.7.1. Radioisotope Sources.
Industrial Irradiator Sources: 93 numbers of Irradiator sources were supplied to
following Irradiator with total activity of 1100 kCi . Out of 93 sealed sources, 34 nos. of
sealed sources was supplied first time to NIPRO, Satara in BC-188 type pencils.
Source Loading at Radiation Processing Plant NIPRO Satara
NIPRO, Satara
Jhunsion Chemical Pvt. Ltd. Bhiwadi
AV Processors Pvt. Ltd., Ambernath
RVNRL, Kottayam
ISOMED, Trombay
RPP, Vashi
- 274 kCi
- 300 kCi
- 150 kCi
- 50 kCi
- 178 kCi
- 200 kCi
10
Cobalt-60 Rack Design of NIPRO Irradiator
More irradiator sources are expected to be supplied in the last quarter of 2012-2013 :
Universal Medicap Vadodara
Agrosurg Irradiators (India) Pvt. Ltd. Vasai
Install and Operate Irradiator
NIPRO, Satara
- 200 kCi in Jan 2013.
- 200 kCi in Jan 2013
- 50 kCi in Jan 2013
- 900 kCI in April 2013
Radiography Sources : 900 Ir-192 Radiography Sources with a total activity of 38 kCi,
7 Co-60 Radiography Sources with a total activity of 400 Ci and 1 Tm-170 radiography
source with 10 Ci activity were fabricated and supplied to various NDT users in the
country. Another 500 Ir-192 radiography sources and 3 Cobalt-60 sources are likely to
be supplied later in the year. One source of 30 Ci was loaded for export to Italy in TK
100 camera.
Custom Made Sources: Following Custom Made Radiation Sources for Nucleonic
Gauges and uses were made :
Co-60
Cs-137
Tm-170
: 32 sources with activity of 2287 mCi
: 3 sources with 214 mCi
: 1 source of 10 Ci
Gamma Chambers : One Gamma Chamber (GC 5000) unit was loaded with 10473 Ci
of 60Co- Cobalt activity. Another Gamma Chamber (GC 1200) unit was loaded with 4950
Ci in the form of 22 pencils. Two more Gamma Chambers (GC 1200) are likely to be
supplied in the financial year. The decayed sources were removed from 2 number of GC
900 and one Gammacell 200 units. 15 Numbers of GC-4000 pencils unloaded from GC-
11
4000 unit supplied to Uruguay have been brought to India , The sources were brought
from USA in two numbers of Type A lead pots. Both the packages were sent back to
USA after removal of sources.
Blood Irradiators: Five Blood Irradiators (BI 2000) were loaded with approx. 808 Ci of
60
Co-Cobalt activity in each. A total number of 47 pencils were loaded in these units.
Another 27 sources are ready for loading in three BI 200 units.
A 3 Ci Ir-192 HDR source was fabricated for the indigenous HDR unit for the first time
after the installation of the 3 port laser system in RLG Hotcells. This is being used for the
radiometry of the HDR transport flasks. Two sources with 6-7 Ci will be fabricated for
testing in HDR Unit developed by BRIT.
Radiometry of HDR Flask
At regional center, RAPPCOF, KOTA a total activity of 861 kCi in 17 sub assemblies
was processed and 1170 kCi of activity was transported in 12 consignments. Another 6
consignments with 600 kCi are expected to be transported before 31st March 2013.
Special permission for the transportation of the absorber rods were taken from AERB
and 8 Numbers of Co-60 absorber rods were transported from KAIGA to RAPPCOF. 4
Numbers of absorber rods from RAPS-2, 8 Nos of absorber rods from RAPS-3 were
unloaded during this financial year for the fabrication of the irradiator sources. 15
numbers of W-91 sources were fabricated at RAPPCOF. Two teams of RAPPCOF has
carried out source loadings at OGFL and JCPL, Bhiwadi successfully.
4.7.2. Gamma Radiation Processing Services (GRPS)
12
4.7.2.1. Radiation Sterilization Plant for Medical Products (ISOMED)
About 82000 boxes admeasuring approx 7000 Cubic Metre were processed in the
facility fetching a revenue of 290 lakhs approx in the year 2012-13.
The average plant utilization was 96% in the fiscal 2012-13 with 100% load availability in
respect of terminal sterilization of healthcare products. The 24×7 facility operation
ensured in full compliance to the requisite statutory requirements from the regulators /
certification agencies. An average customer feed back rating of over 85% was
maintained throughout the year during the course of gamma radiation processing
services thus meeting the quality management system objectives framed for the year.
The facility has received ISO 13485:2003 certification along with ISO 11137:2006 part 1
which is expected to fulfill one of the essential requirements in the changing business
environment as far as radiation sterilization of medical products is concerned. Actions
have also been initiated for the accreditation process in respect of OHSAS – 18000.
To facilitate swift radiation processing of the customer’s consignments, Source Strength
in the facility has been augmented by around 66% in November 2012. The current
Source Strength in the facility is now around 400 kCis.
4.7.2.2 Radiation Processing Plant, Vashi (RPP, Vashi)
Radiation Processing Plant, Vashi is providing gamma radiation processing services for
Spices, Ayurvedic raw material, healthcare products and pet feed etc. to more than 200
customers from all over the country. Twenty new customers for Spice, Ayurvedic raw
material and pet feed were registered with the facility during this period.
During the current financial year, about 2800 MT of spices and other products were
processed till December 2012 which is more than the quantity processed during the
corresponding period last year (2700 MT) despite the decay in the source activity.
Revenue generation till December 2012 is about 200 lakhs which is about 20% more
than the revenue generated in corresponding period last year (160 lakhs). This year the
plant is expected to process around 3500 MT spices and allied products yielding
revenue of about 250 lakhs. Since its inception, this facility has processed about 23000
tonnes of products realizing revenue of about Rs. 1400 lakhs.
Source replenishment was carried out to enhance source strength from 400 kCi to 600
kCi. to cope up with the increased demand for radiation processing. Re-certification
Audit for ISO-9001:2008 (Quality Management Systems) was completed successfully
and facility was certified for three more years. Surveillance Audit for ISO-22000:2005
(Food Safety Management Systems) was carried out by certifying agency and found in
full compliance with standard’s requirements.
Facility of e-payment has been provided to customers for payment of processing
charges.
13
MoU signed with M/s Divyakiran for Radiation Processing Plant at Anand, Gujarat
4.7.2.3 New Radiation Processing Plants in Private Sector
Two Radiation Processing Plants namely, M/s Hindustan Agro Co-Operative Ltd.,
Rahuri, Maharashtra with source loading of 65 kCi and M/s Nipro India Corporation Pvt.
Ltd, Pune with source loading of 275 kCi were commissioned.
14
Radiation Processing Plant at Nipro India Corpn. Ltd., Pune is commissioned
Mou was signed with M/s Isorad Tech Pvt Ltd, Chennai, M/s Divyakiran Agro Processing
Pvt. Ltd, Anand, Gujarat and M/s Radura Irradiators, Nashik, Maharashtra for setting up
of Radiation Processing plant.
15
MoU signed with M/s Isorad, Chennai
4.7.2.5 EB Processing
A crosslinked polymer blend material for mouldable electrical insulation components
meeting IEC standards were developed using 2 MeV electron beam ILU-6 EB
accelerator. Optimum compositions of LDPE and EVA were blended without the use of
conventional curing agents. The material finds various applications as HV electrical
insulation components. The crosslinked material can be shaped into desired geometry
using vacuum moulding technique at around 150o C.
Electron Beam commercial processing services were continued at ILU-6 facility at Vashi.
4.7.3. Radiation Technology Equipment
4.7.3.1. Gamma Chambers
During the current financial year various gamma chambers have been supplied and
some others are to be supplied to the following Institutes/organizations.
•
•
Gamma Chamber GC 1200 supplied and installed at National Botanical
Research Institute, Lucknow.
A Low dose Irradiator has been supplied and installed at INMAS, New Delhi.
16
•
•
•
A Gamma Chamber 5000 unit is ready for export to Bangladesh Institute of
Nuclear Agricultural, Mymensingh, Bangladesh. It will be delivered by road
through M/s. Danver Hydromatics, Kolkata for US$ 159,000 FOB.
Gamma Chamber (GC 5000) for RSD, BARC, Gamma Chamber GC 1200 for
Dr. Ambedkar University, Lucknow are to be supplied later.
Source replenishment for one Gamma Chamber 900 unit is in progress for
supplu later.
During the period 10 units of GC 900, GC 4000A and a Gamma Cell 1200 units were
decommissioned and another 2 units from IIT, Chennai & IMRL Jammu will be
decommissioned in 2012-13.
A new source extraction tool has been developed for removing and transferring the
decayed source from Gamma Chambers to type B(U) packages. The new tool has
been used at Kandy, Sri Lanka for transferring the source from GC 900 to BLC 100.
4.7.3.2. Blood Irradiator 2000
Blood Irradiator 2000 units were supplied and installed at
•
•
•
Rajeev Gandhi Cancer Institute, Delhi,
Surat Raktadan Kendra, Surat
Apollo Hospital, Hyderabad
Another 2 units are being supplied by the end of February to
•
•
L&T Chennai- unit will be installed at JIPMER, Pondicherry &
IMS & SUM Hospital, Bhubaneswar.
4.7.3.3. Radiography Camera ROLI-1 & III
BRIT supplied 58 radiography exposure devices up December 2012. It is expected to
sell another 30 cameras by March 2013.
500 ROLI cameras were serviced, nearly 1000 decayed sources were removed, 800
imported cameras were inspected for approval of source replenishment. A new
radiography camera model ROLI-2 was introduced in November 2012.
4.7.3.4. Install & Operate Irradiator
Install and irradiate operator has been installed and functional test has been carried out
successfully.
4.7.3.5. QA of Sealed Sources, Radiometry Scanning and Irradiation Services
ROLI 1 cameras were tested at the REPF workshop and the Radiological lab of BARC.
Density measurements were carried out on cobalt-59 pellets and slugs and also
17
chemical analysis and XRF analysis were carried out for the acceptance of the material
for irradiation.
All the sealed sources were subjected to the various quality control checks before
release.
4.7.3.6. Isotope Application Services
Various radioisotopes, in sealed form and open sources were used for several
troubleshooting applications in industries.
Radiotracer technique was successfully used for leak detection in series of heat
exchangers at Chennai Petroleum Corporation Limited (CPCL), Chennai and Bharat
Petroleum Corporation Limited (BPCL), Mumbai. The refineries experienced problem of
high sulphur content in rundown diesel which indicated a leak from feed (shell side) to
reactor effluent side (tube side) in one or more than one heat exchangers (in series).
Placement of detectors in heat exchangers for leak detection at CPCL, Chennai
However locating a leaky heat exchanger using conventional technique was a difficult
task since there are seven breech lock heat exchangers in series at CPCL and ten heat
exchangers in series at BPCL. Conventionally leak could be identified only by
hydrotesting of individual heat exchanger which would have extended downtime of the
18
refinery. However, on-line radioisotope techniques using
heat exchangers could be exactly identified.
82
Br as radiotracer, the leaky
Gamma scanning of process columns were carried out in various refineries and
chemical industries for troubleshooting. The technique provided on-line and fast
identification of problematic zones in the process columns. The gamma scanning was
carried out by using sealed source 60Co.
Interface detection for HF settler Tank settler at Reliance Industries Ltd.
Interface detection of hydrofluoric acid (density 0.98 g/cc) and hydrocarbons (density
0.84 g/cc) was successfully carried out in a closed hydrofluoric settler tank for Reliance
Industries Limited, Patlaganga.
19
Tangential pipe profiling in progress at HPCL, Mahul, Mumbai
4.14. Supporting Services
4.14.1. Customer Support
Customer Support Programme provides various kind of support for the regular and
uninterrupted supply of radioisotopes & allied products and radiation technology
equipment to about 2000 user institutions in the healthcare, industrial, research and
agricultural sector.
BRIT continued to serve its customers through various modes of interactions with them
to support co-ordination with the officials of BRIT and regulatory authorities in the
matters related to procurement and use of radioisotope products, services and
equipment. The retail outlet for supply of cold kits to nuclear medicine user institutions in
and around Mumbai.
The transportation of about 50000 consignments of radioisotope and allied products,
majority of them by air was carried out in a safe manner. Major transportation activities
carried out during the year includes movement of kilocurie amounts of radioactive
sources from RAPPCOF, Kota to Mumbai, and transportation iof industrial irradiator
sources from Mumbai to Satara, Bhiwadi, Ambernath, Kottayam and teletherapy sources
from Mumbai to various cancer hospitals in the country and Gamma Chamber and Blood
Irradiator units to various research centres and hospitals.
20
BRIT website provided information on the products, services and various other activities
of BRIT. The airway bill numbers for the despatched products are displayed on website
on a continuous basis. Frequent updates on receipt, inspection and ready for despatch
status of radiography cameras helps NDT customers considerably. Organizational
structure, telephone and email directory, annual report and milestones of BRIT are some
other web pages that are modified periodically. Changes were implemented to adopt to
new VPN services of NIC for BRIT. Hundred new email accounts in the domain
britatom.gov.in have been obtained to strengthen a committed support to our customers.
Radioisotopes and allied products supplied by BRIT
Sr.No
Item
1
2
3
Consignments
Activity
Sale Value
Actual between
April-December, 2012
50000
1000 kilo curies
Rs. 5000 lakhs
Expected to be achieved
April, 2012 – March, 2013
≈ 60000
≈ 1500 kilo curies
Rs. 7000 lakhs
4.14.2. Engineering Services
Engineering services provided the vital infrastructure and utility services to BRIT and
BARC facilities at Vashi Complex, Project House at Deonar and ISOMED at Trombay.
A centralized Radiation Equipment Production Facility (REPF) workshop of Engineering
Services equipped with vital infrastructure (including 2 nos. of 10 Ton capacity EOT
cranes, 7 ton Capacity Forklift ) provided the technical support and services to various
sections of BRIT such as Radiography Cameras, Laboratory Irradiators, TCGPF, LCO,
and Radiation Processing Plants at Vashi and ISOMED at Trombay to meet their
required flow processes of production and supply schedules as planned.
Preliminary set up work of Calibration laboratory for Radiation measuring instruments
including modification, design and development of exposure device has been brought to
next level of work along with by workshop.
During this year constant technical support has been provided by the workshop to
Isotope Application Services (IAS) in gamma scanning work executed at HPCLMumbai, RIL- Gujarat and PRIVI Organics at Mahad.
Regular technical support and services has been provided to execute the commissioning
work of Mobile Hot Cell under progress.
In the current year the workshop has planned to execute the eight fabrication work order
from Sealed Source group. BC188 type source transportation cages (each carries nearly
100-125 KCi Cobalt) to supply the source to domestic and international Irradiators.
Status of the Plan Projects
X Plan Projects
21
BRIT has taken up several projects for execution under the plan project scheme. All
these projects have been aimed to enhance its capacity for the development of new
products, improvement in quality and also development of infrastructural facilities.
Under the X Plan, in the three major projects, progress has been made as given below:
Project: Integrated Facility for Radiation Technology (IFRT)
Objective of the project is to set up a Hot Cell at BRIT Vashi Complex for handling,
storage and fabrication of sealed sources up 300 kCi of Co-60. The financial outlay of
the project is Rs. 1805 lakh.
This project is in advanced stage of execution as civil construction for administrative
building, water pool, Radiometry room and Hot Cell has been completed. Installation of
crane and ventilation system is in progress. Project is expected to be completed by end
of 2013
Project: DAE Medical Cyclotron Project: Pharmaceuticals Facility
A medical cyclotron facility is being installed at VECC, DAE, and Kolkata for the
production of PET and SPECT radioisotopes to be used for diagnostic and therapeutic
purposes.
Progress:
Major equipment including hot cells has been procured. Isotope for establishing
procedure for production is being procured.
Casting of 10m deep basement which is the most complicated civil work of this project
is about 90% complete. Works in the cyclotron vault area, 2nd floor of the remaining
portion of the building and other service buildings are going on. Civil work is expected to
be completed by June 2013.
XI Plan Projects
The XI plan projects are aimed towards development of new products, improvement in
quality of existing products and improvement in manufacturing processes. An important
project for setting up production facility for the medical grade fission molybdenum was
approved last year. Brief description of the XI plan projects is given below:
1. Project : Integrator Irradiator Development Project
Estimated Cost: Rs.300 lakhs
Objectives
To upgrade safety and security features in the RPP, Vashi and ISOMED facilities and to
set up an Irradiator Training Facility for training of personnel for operation of irradiator.
Progress: The project has been completed and following work has been carried out:
•
Access control system installed at Vashi.
22
•
•
•
•
•
•
System for vehicle tracking system has been installed
Early fire warning system for ISOMED is procured
Aerosol generator has been designed and fabricated
Pamcrash software for safety evaluation of cask has been procured.
Single bag blood irradiator has been fabricated and supplied
Scale down model of Medical sterilizer has been fabricated and supplied
2. Project: Production Facility for 99Mo/ 99mTc Column Generators of High Specific
Activity Mo-99.
Estimated Cost: Rs. 750 lakhs
Objectives
Setting up of a new automated facility for production of
using high specific activity Mo-99.
99
Mo –
99m
Tc Column Generators
The installation of the facility is complete. Cold runs have been completed This project
has been completed as per schedule. AERB approval has been obtained. New product
Coltech has been successfully launched in the market as planned.
3. Project: Construction of State-of–the-Art Immunoassay Facility
Estimated Cost: Rs. 205 lakhs.
Objectives
•
Development of building up of infrastructure for coated tube technology and state
of the art Laboratory with GMP/GLP compliance with a special focus on contract
manufacturing.
•
Development and building up of infrastructure for immunoassay based on nonisotopic labels.
•
Development of diagnostic kits for infectious diseases.
Progress:
Procurement of following equipments needed for development of isotopic/non-isotopic
assays has been completed.
Spectrophotometer
Dehumidifier
Multi-well RIA counter
Laboratory has been refurbished partly
BT reader
RO water system
T3 antibody
23
Last set of equipment is awaited for supply and it is expected that project will be
completed by March 2013.
4. Project: Construction of State-of-the-Art GLP and GMP
Estimated Cost: Rs. 340 lakhs.
Objectives.
Upgradation of the laboratory for GLP and GMP compliance by following:
a. Removal of the existing corroded 20 years old fume hoods, cut and disposal
through WMD.
b. Installation of new fume hoods
c. Wear resistant laboratory flooring of Laboratory.
d. Furnish the lab and facelift office for aesthetic look.
e. Introduce the state of the art synthesis facility, enhance the analytical
evaluation, quality control of the labeled compounds. Introduction of
microwave synthesis and introduction of instrumental analysis.
f. Augmentation of oligo-nucleotides synthesis facility.
g. Setting up of state of the art lab for C-14 urea capsule production and
h. Setting up of low background counting lab food analysis.
Progress: Following work has been carried out
•
•
•
•
•
Decontamination of working tables and fume hoods in two laboratories is
completed
Procurement of stainless steel fumehoods (12 Nos), new working tables,
flooring, paneling etc.
HPLC instrument is procured
UV spectrophotometer and Portable liquid scintillation is procured.
12 nos of Fume hoods fabricated and supplied
Installation of Fume hoods is in progress and project is expected to be completed by end
of 2013.
5. Project: Indigenous HDR Brachytherapy Equipment (IHDR)
Estimated cost:
Rs. 800 lakhs
Objectives:
a) Establishing the complete process and facilities for fabrication of Ir-192 HDR
b) sources for regular production.
c) Development of indigenous, remote operated high dose rate (HDR)
brachytherapy equipment including necessary treatment.
Progress:
Second prototype of KARKNIDON, HDR treatment unit has been made. Unit has under
gone more than 50,000 cycle of operations. Reliabilities and robustness of stepper drive,
24
Safety interlocks, linear accuracy, repeatability, hardware & software were tested and
recorded. Weaker components and software corrections are incorporated to ensure
conformance of code. The second machine has been upgraded systematically and is
much superior in technology to the earlier version. Third party evaluation will be
undertaken by involving RPAD/BARC, prior to clinical trials.
Development of Treatment planning software for the KARKNIDON, also been initiated.
One type of Steel applicator suitable for the treatment of cervical cancer, already been
developed.
Prototype of Karknidon – HDR Treatment unit for cancer
6. Project: Setting up of facility for
Molybdenum
production of
medical grade Fission
A new project “Setting up of Medical use Mo-99 production (LEU fission based) facility”
under XI plan has been sanctioned for BRIT by Atomic Energy Commission. Project is
scheduled to be completed by 2014.
Estimated Cost Rs. 128 crore
The project consists of setting up of a State-of-the Art GMP compliant facility capable of
producing 300 Ci (6 day pre-calibrated) per week 99Mo utilizing LEU targets. The scope
includes commissioning of modern hot cells equipped with manipulators, in cell
equipments, radiation surveillance instrumentation and data logging system, special AC
& ventilation system, waste management equipments, civil construction of building and
25
setting up of world class quality control labs, modern security system, construction of
new building at approved site in ISOMED Complex, BRIT near South Gate BARC.
The completion of this project will let BRIT take off to larger scales of production of 99Mo
-99mTc column generator Kits in the Indian market. Kits with larger quantity available at
the radiopharmacy level and uninterrupted distribution will enable BRIT to deepen the
existing demand for kits as well as enlarge the customer base to include new Nuclear
Medicine centers opening in the non-metro towns of India. With global shortage of 99mTc
kits looming in the world market, BRIT will act as a major provider of the kit in times to
come.
Objectives
• Mo-99 production (LEU fission based) facility
• Supply Fully indigenous column generators to various diagnostic centres and
hospitals in the country.
Progress :
After the site clearance from AERB and the designs for the building are submitted to
AERB, The work on construction of building has been taken up by DCSEM in parallel.
As recommended by BARC and safety authorities, the work of construction of new RCC
boundary wall for the ISOMED complex, new Watch tower and installation of new safely
features was included in the scope of civil work. The work on the construction of new
RCC boundary wall is nearly complete. Now work on construction of watchtower is being
taken up and new electric security fencing and provisions are being made for installation
of other security equipment. Work on the construction of main laboratory building has
also started and the foundation piling work of 169 piles of total of 184 piles is complete.
Main Laboratory Building under construction
26
Work on procurement of the production plant, on turnkey basis, is in advanced tender
processing stage through DPS.
Boundary wall under construction
27