RARB Antibody
CATALOG NUMBER: 30-076
Antibody used in WB on Human brain at
Antibody used in IHC on Human brain.
0.2-1 ug/ml.
Specifications
SPECIES REACTIVITY:
Human, Mouse
TESTED APPLICATIONS:
ELISA, WB
APPLICATIONS:
RARB antibody can be used for detection of RARB by ELISA at 1:62500. RARB antibody can be used for
detection of RARB by western blot at 0.5 ug/mL, and HRP conjugated secondary antibody should be diluted
1:50,000 - 100,000.
USER NOTE:
Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:
1) Cat. No. XBL-10123 - Fetal Brain Tissue Lysate
PREDICTED MOLECULAR
50 kDa
WEIGHT:
IMMUNOGEN:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RARB.
HOST SPECIES:
Rabbit
Properties
PURIFICATION:
Antibody is purified by peptide affinity chromatography method.
PHYSICAL STATE:
Lyophilized
BUFFER:
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 uL of distilled water. Final antibody concentration is
1 mg/mL.
CONCENTRATION:
1 mg/ml
STORAGE CONDITIONS:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store RARB antibody at -20˚C. As
with any antibody avoid repeat freeze-thaw cycles.
CLONALITY:
Polyclonal
CONJUGATE:
Unconjugated
Additional Info
ALTERNATE NAMES:
RARB, HAP, NR1B2, RRB2, MCOPS12
ACCESSION NO.:
NP_000956
PROTEIN GI NO.:
14916494
OFFICIAL SYMBOL:
RARB
GENE ID:
5915
Background
BACKGROUND:
RARB is a retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear
transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds
retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic
morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by
regulating gene expression. This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid
hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and
to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates
cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits
growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular
carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants;
one additional transcript has been described, but its full length nature has not been determined.
REFERENCES:
1) Uhl, G.R., (2008) Arch. Gen. Psychiatry 65 (6), 683-693.
FOR RESEARCH USE ONLY
October 2, 2016