The Royal Australian and New Zealand College of Radiologists® RADIATION ONCOLOGY TRAINING PROGRAM CURRICULUM Page 2 © 2012 RANZCR. Radiation Oncology Training Program Curriculum With the discovery of X-rays in the late 19th century and the study of radioactivity by Marie Curie and colleagues in the early 1900s, came a new era in medicine. The realisation that some types of radiation (X-rays, electrons and gamma rays from radioactive materials) destroy malignant cells, infinitely expanded our capacity to treat cancer. Over the last 100 years, the full potential of radiation in curing many cancer patients, and relieving distressing symptoms (palliation) for others, has unfolded. This stream of medicine has grown into the modern specialty of Radiation Oncology. incorporates direct clinical management of patients of all ages, with a uniquely effective treatment modality. It is a specialty that will allow you to have meaningful interactions with patients and their families, and to be a key player in their overall care. Again, welcome. A/Prof. Sandra Turner Chief Censor Radiation Oncology Clinicians who specialise in Radiation Oncology play an integral role in the complex multidisciplinary team management of cancer patients. Their practice is strongly underpinned by a detailed knowledge of the biological effects and physics of radiation, of pathology and anatomy as they relate to cancer and its control, and of the application of sophisticated imaging and treatment technologies. Paramount is an extensive understanding of all clinical aspects of cancer management. Radiation Oncologists are trained to be competent beyond their role as clinical and technical experts. Our Fellows are required to be excellent communicators, above all with our patients, to work in a close and collaborative fashion with radiation therapists, medical physicists, surgeons, medical oncologists, palliative care physicians and radiologists amongst others; to practice evidence-based medicine, and to take part in research and other academic pursuits, including teaching. These skills and expertise enhance the value of the specialty for the community. They are required to advocate effectively for their patients and for their profession. Welcome to this, Version 2, of our modern curriculum for training in Radiation Oncology. This document refines and updates the previous ‘new’ curriculum without changing the overall statements of the knowledge and skills required for our speciality. If you are commencing training in Radiation Oncology, you are entering an intellectually challenging and exciting career. This is a rapidly evolving specialty incorporating many varied specialised procedures and options for academic pursuits. It is highly rewarding in that it © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 3 CURRICULUM INTRODUCTION Foreward by the Chief Censor Page 4 © 2012 RANZCR. Radiation Oncology Training Program Curriculum TABLE OF CONTENTS GOALS OF TRAINING PROGRAM CURRICULUM BACKGROUND TO CURRICULUM DEVELOPMENT 9 TRAINING PROGRAM STRUCTURE 11 • LEARNING PORTFOLIOS 11 • THE TRAINEE AND NETWORK TRAINING CENTRE(S) PARTNERSHIP 12 INTRODUCTION TO THE CanMEDS ROLES 13 • ROLE STATEMENTS 14 HOW TO USE THIS CURRICULUM DOCUMENT 15 ROLE 1: MEDICAL EXPERT17 • RADIATION ONCOLOGY PHYSICS 21 • RADIATION AND CANCER BIOLOGY 27 • ANATOMY 32 • PATHOLOGY 35 RADIATION ONCOLOGY CENTRAL KNOWLEDGE & SKILLS SUMMARY (ROCKSS) 39 MEDICAL EXPERT SUPPLEMENT TOPICS 42 • Breast 43 • Lung and Mediastinum 47 • Head and Neck 53 • Skin 57 • Male Reproductive System 61 • Female Reproductive System 67 • Urinary Tract 73 • Gastrointestinal Tract 77 • Central Nervous System 87 • Haematology 97 • Musculoskeletal and Connective Tissue 103 • Paediatrics 109 • Endocrine 113 • Metastatic Disease 117 • Non-Malignant 121 • Clinical Oncology 123 LEARNING OPPORTUNITIES 127 ROLE 2: COMMUNICATOR131 ROLE 3: COLLABORATOR135 ROLE 4: MANAGER139 ROLE 5: HEALTH ADVOCATE143 ROLE 6: SCHOLAR147 ROLE 7: PROFESSIONAL151 DESCRIPTION OF ASSESSMENTS 155 GLOSSARY 161 ALPHABETICAL INDEX OF MEDICAL EXPERT SUPPLEMENTS 165 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 5 Page 6 © 2012 RANZCR. Radiation Oncology Training Program Curriculum CURRICULUM INTRODUCTION CURRICULUM INTRODUCTION © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 7 Page 8 © 2012 RANZCR. Radiation Oncology Training Program Curriculum CURRICULUM INTRODUCTION Goals of the Radiation Oncology Curriculum This document aims to: • Articulate the knowledge, skills and attributes of a Radiation Oncologist • Provide direction to help trainees acquire the necessary competencies • Provide stimulus for potential learning opportunities and give guidance as to how to maximise benefit from these • Demonstrate the integration and links between various areas of knowledge and their application in clinical practice • Present a framework for trainee progression through the program • Describe the assessments used across the training program • Promote regular and productive interaction between trainees and supervisors, through the use of formative in-training assessments • Indicate where learning materials and resources may be found Background to Curriculum Development The process culminating in the publication of the first edition of this document occurred between 2004 and 2008. It involved widespread consultation between the Fellows of the Faculty of Radiation Oncology (“The Faculty”) of The Royal Australian and New Zealand College of Radiologists (RANZCR) as well as many other parties. In 2004, the Faculty Board advised that a comprehensive review of the Radiation Oncology training program be undertaken. The impetus for change emanated from three areas. The main trigger was evolution of modern educational and evidence-based adult-learning concepts, including the increased use of formative in-training assessments. At the same time, recognition by Fellows and trainees of the vagaries of the previous syllabus and assessment led to a desire to increase the objectivity and clarity of all aspects of training. Furthermore, important governmental bodies in the realm of accreditation of Medical Colleges (in particular the Australian Medical Council) were arriving at similar conclusions that were reflected in requirements to all Medical Colleges. As the initial step, the Curriculum Advisory Committee (CAC) was convened, including many members of the Faculty significantly involved in education, as well as others with an interest to become more involved. It also included trainee representatives, representatives of the public (consumer representatives) and RANZCR secretariat members, in particular the newly appointed RANZCR Head of Education and Research. A consultant expert in postgraduate medical education from the University of New © 2012 RANZCR. Radiation Oncology Training Program Curriculum South Wales advised throughout the development process and remains involved. The process of defining the scope of the modern Radiation Oncologist’s role was followed by establishing a framework for the shape of the new program, in parallel with filling out the content of the curriculum document. The common core competencies evolved and continued to be refined by the CAC group during the course of the project. Most members of the Faculty were involved in writing and reviewing one or more sections dealing with specific tumour sites. Most topics were reviewed several times and the final document draft was circulated widely for comment. Since the release of the first edition in 2008, several ongoing reviews of curriculum components have been completed and feedback has been sought through the implementation phase of the ‘new’ (now considered current) curriculum. This has resulted in some, mostly minor, changes to subject content and scope. This has been reflected by related in-training and summative assessments, and training tools. This 2012 version (second edition) contains all of these changes and updates. At the time of printing, a formal independent (external) review of all aspects of the curriculum, including training Network operation and curriculum delivery, is in development. The entire development and review of this curriculum to date has occurred with the direct involvement of the Education Boards - past and present - with members listed below. The Faculty Board has retained oversight of the curriculum development and subsequent updates, with their input and approval sought in every matter. As a subgroup of CAC and/or Education Boards, Page 9 the Radiation Oncology Curriculum Editorial Teams 1 & 2 (ROCET 1 & 2), have had the task of editing, organising and formatting these documents. ROCET’s roles also included the coordination of the review process, addressing comments, advising on artwork and communicating Curriculum development issues back to the Education Board and Faculty Board. This Curriculum represents a large body of work achieved as a cooperative effort by a large number of people both within and outside The Faculty. This document will continue to be reviewed and updated in order for it to retain relevance and to meet the goals for which it was designed. Education Board Members 2006-2009 A/Prof Martin Berry (Chief Censor) A/Prof Roger Allison (Dean) Dr Sandra Turner Dr Matthew Seel Dr Chakiath Jose Dr Rahul Mukherjee Dr Tanya Holt A/Prof Graham Stevens (Chief Accreditation Officer) Dr Amy Shorthouse (Trainee Representative) Dr Bronwyn King (Trainee Representative) Dr Mark Sidhom (Trainee Representative) Education Board Members 2010-2012 Radiation Oncology Curriculum Editorial Team 1 Members 2007-2008 Dr Sandra Turner (Chair) Dr Matthew Seel Dr Mary Dwyer Dr Kirsty Stuart Ms Ally Keane Radiation Oncology Curriculum Editorial Team 2 Members 2011-2012 Dr Tanya Holt (Chair) Dr Margot Lehman (co-Chair) A/Prof Sandra Turner Ms Bianca Heggelund A/Prof Sandra Turner (Chief Censor) A/Prof Chris Milross (Dean) Dr Denise Lonergan Dr Tanya Holt Dr Margot Lehman Dr Melissa James Dr Mark Lee Dr Michael Penniment A/Prof Phillip Yuile (Chief Accreditation Officer) Dr David Kok (Trainee Representative) Dr Andrew Lee (Trainee Representative) Dr Evan Ng (Trainee Representative) Dr Angela Allen (Trainee Representative) Page 10 © 2012 RANZCR. Radiation Oncology Training Program Curriculum This curriculum document outlines the structure of our training program, the knowledge and skills we expect our trainees to develop and the nature of the various assessments that occur throughout the training program. The training program is structured in two major phases. The two-phase structure is designed to aid the organisation of learning through the course. Phase 1 extends from the trainee’s commencement in training through to approximately 18 to 24 months into the program. Phase 2 extends over the remainder of the program, from the satisfactory completion of Phase 1 through to a minimum of 5 years from program entry. The exact length of each phase is determined by trainee progress and achievement of certain milestones, not a pre-determined time period. Within Phase 1, there is a loosely-defined ‘Foundation’ period (approximately the first 6 months after entry) during which essential background knowledge is acquired, as well as familiarity with the new training centre. Learning outcomes are closely linked to the various assessments throughout the training program. See below for further information on assessments and the concept of Learning Portfolios. There is a Phase 1 examination and a Phase 2 examination. Trainees who are progressing well through Phase 1 are able to undertake some of the activities (e.g. Case Reports) that are predominantly linked to Phase 2 of the program. For more specific information regarding individual assessments, please refer to the Assessments section and the Assessment Toolkit. Progression through the program occurs by the achievement of regular satisfactory assessments made or signed-off by Clinical Supervisors (all Radiation Oncologists who work directly with trainees) and Directors of Training. LEARNING PORTFOLIOS Each trainee will have a Learning Portfolio that is used across the whole program to compile the “evidence” of their learning and activities, helping to demonstrate that the specified skills and knowledge of a Radiation Oncologist have been acquired. These Portfolios provide trainees with the opportunity to show how completely they have met the requirements of the curriculum. There are, therefore, minimum and mandatory requirements for © 2012 RANZCR. Radiation Oncology Training Program Curriculum the contents of the Portfolio that become the core nonexamination based assessment for each trainee in the program. The Learning Portfolio also provides trainees with an opportunity to individualise their learning within areas of particular interest. This is achieved by the inclusion of other materials and documentation that supports their activities and study over the course of their training and professional development. There are many examples of potential learning activities contained within this curriculum. In this way, the portfolio may represent a type of “Curriculum Vitae” of an individual’s training experience and achievements. Modern assessment methodologies included in this curriculum and contributing to the Portfolio are miniclinical evaluation exercises (mini-CEX) which provide feedback to trainees on patient interactions and multisource feedback (MSF) surveys assessing trainee’s communication skills and ability to work as a team member. Other assessments include Clinical Supervisor Assessments (CSA) of each term, Trainee Assessment of Training Terms (TATTs) and a six-monthly review by the Director of Training (DoT). The Phase 1 Foundation Modules and Clinical Assignments, aim to guide and ensure learning of the Oncology Sciences subject material. These are incorporated into the Learning Portfolio in Phase 1. There are also requirements in relation to Practical Oncology Experiences (POEs) which involve protected time spent gaining exposure to facets of radiation treatment planning, treatment delivery and oncology anatomy. In Phase 2, trainees are required to meet the Statistical Methods, Evidence Appraisal and (Trainee) Research (SMART) requirements and these form part of the Phase 2 portfolio sign-off. Portfolios will also contain a number of Case Reports (as a type of learning-focused ‘log book’) dealing with management and technical issues across the spectrum of tumour sites and special radiation therapy techniques and cancer procedures, as well as some general clinical oncology scenarios. These special techniques and procedures have a practical component and ensure some exposure, across the training Networks, to brachytherapy, paediatrics, total body irradiation, stereotactic radiation therapy and surgical oncology procedures. Page 11 CURRICULUM INTRODUCTION TRAINING PROGRAM STRUCTURE THE TRAINEE AND NETWORK TRAINING CENTRE(S) PARTNERSHIP Trainees will require a satisfactory Portfolio assessment in order to progress from Phase 1 to Phase 2 and to be eligible to sit the Phase 2 examination. Maintenance of the Learning Portfolio is the responsibility of the trainee. As described above, this curriculum describes the compulsory content requirements but trainees are encouraged to include additional relevant material. All activities undertaken should be referenced to the learning outcomes in the Curriculum and/or those outlined in the Portfolio itself. Review of the Learning Portfolio will be undertaken sixmonthly by the Director of Training and the trainee, with the expectation that barriers to successful completion of assessments can be identified early and rectified. The Faculty Trainee in Difficulty Policy details the processes and flags for identifying and assisting trainees that are not progressing or who are having other problems in training. In addition it outlines tips and strategies for remediation. From January 2012, all trainees entering the Faculty of Radiation Oncology training program will operate under the accredited training Network rules and guidelines (see the Training Network Guidelines Policy and Training Network Accreditation Standards documents on the College website for details at http://www.ranzcr.edu.au/ radiation-oncology/training-in-radiation-oncology). The training Network and constituent centres are responsible for ensuring each trainee has access to the experiences and support required for completion of the training program. Maximising these opportunities was the main rationale for mandating networked training in Radiation Oncology. Mentoring of the trainee is part of the support expected. Diagram of Training Program Structure Phase 1 Phase 2 SMART Points accural completed Advanced Trainee (5th) Year Research Project submission KEY FoundationClinical Practical ModulesAssignmentsOncology Experiences Case Other Portfolio Reports Activities eg. mini-CEX, TATTS, DoT Assessments Page 12 Phase 1 & 2 Examinations © 2012 RANZCR. Radiation Oncology Training Program Curriculum The Royal College of Physicians and Surgeons of Canada described the seven roles of a doctor as: Medical Expert, Communicator, Collaborator, Manager, Health Advocate, Scholar and Professional. These were named the Canadian Medical Education Directives for Specialists (CanMEDS). The role of Medical Expert is seen as central to the work of a Radiation Oncologist. The other six roles are also important, and together the seven roles are intended to encompass all aspects of our profession. There is much overlap across the roles, but this model does allow for some individual focus on the various aspects of professional life as a Radiation Oncologist. Adapted from the CanMEDS Physician Competency Diagram, with permission of the Royal College of Physicians and Surgeons of Canada. Copyright©2009 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 13 CURRICULUM INTRODUCTION INTRODUCTION TO THE CanMEDS ROLES ROLE STATEMENTS This RANZCR Radiation Oncology Curriculum is built around the general CanMEDS concepts and is organised around the seven key roles as they relate to a Radiation Oncologist. Role 1: Medical Expert Central to the role of the Radiation Oncologist is the interaction with the person with cancer. The Radiation Oncologist: •Synthesises oncological knowledge with clinical information to formulate and convey a plan of management •Applies technical expertise in carrying out planning and delivery of management programs, in particular those involving radiation therapy •Devises and conducts an effective program of patient assessment throughout and beyond initial treatment •Coordinates psychosocial and physical care during the follow up period, including delivery of further courses of radiation therapy and management of other cancer and treatment-related problems The Medical Expert role draws on the competencies included in the roles of communicator, collaborator, manager, health advocate, scholar and professional. Role 2: Communicator The Radiation Oncologist: •Establishes a professional relationship with the patient and their family, and is sensitive to their illness, social situation and cultural background •Is expert in eliciting and synthesising relevant history and patient preferences by directed questioning and effective listening •Discusses information with patients, their families and their health care team, using appropriate language •Maintains ethical and effective verbal and written communication with other practitioners, in all roles Role 3: Collaborator The Radiation Oncologist: •Establishes and maintains interpersonal co-operative relationships with patients •Establishes and maintains interpersonal co-operative Page 14 relationships with other healthcare providers •Facilitates optimal patient care both in the outpatient and inpatient setting • Participates in research and educational activities Role 4: Manager The Radiation Oncologist: •Optimises decisions regarding individual patient care in the context of finite health care resources • Provides leadership in healthcare organisations •Ensures effective work practices through staffing and the development of policies and procedures based on appropriate use of information systems Role 5: Health Advocate The Radiation Oncologist: •Applies expertise and influence, whether individually or as part of a group, to improve cancer services on behalf of individual patients, groups of people with cancer and the community at large Role 6: Scholar The Radiation Oncologist: •Engages in life-long learning with the goal of continuously improving his or her mastery of the discipline •Contributes to the collection, analysis and interpretation of data that relate to health care quality and outcomes • Critically evaluates scientific literature and research • Integrates emerging evidence into clinical practice •Participates in the education of peers, trainees, other health care providers, and community bodies •Actively participates in advancing knowledge in the clinical and laboratory settings Role 7: Professional The Radiation Oncologist: •Delivers the highest level of patient care with integrity, honesty and compassion •Exhibits exemplary personal and interpersonal behaviour, and practices ethically •Practices with diligence and active concern for the progress of the profession, while continuing to improve mastery of the discipline © 2012 RANZCR. Radiation Oncology Training Program Curriculum In this document, each of the seven roles of a Radiation Oncologist is defined and expanded by the use of a role statement and these statements are illustrated further with learning outcomes. Learning outcomes describe the expected abilities or competencies required of a Radiation Oncologist. When listed as a group of learning outcomes, these are usually prefaced by the common stem “The trainee is able to:”, indicating that these are defined expectations of competence at a level necessary at the completion of Radiation Oncology training. It is important to recognise that the learning outcomes within this curriculum are those that apply to a Radiation Oncologist about to commence independent clinical practice i.e. just at the completion of training. In particular, a high level of sub-specialist knowledge is not expected. Not all learning outcomes need to be achieved to the same level. The levels of achievement for the learning outcome statements in this curriculum are denoted as follows: [D] =A Detailed level of knowledge, and ability to apply this knowledge in clinical settings, is required [G] =A more General level of knowledge, and minimal application of this knowledge, is required [I] =Ability to perform the specified activity essentially Independently [S] =Ability to perform the specified activity under Supervision trainees in achieving the learning outcomes. Not all activities are required to be undertaken and some will clearly be much more complex and challenging than others. These opportunities are suggestions for activities that the trainee may seek out during their training. They will help the trainee develop and establish related capabilities, and a better understanding of that particular role. When listed as a group of learning opportunities, statements are prefaced by the common stem “The trainee may:”, in order to capture the concept that these are suggestions and not absolute requirements for training. The list of learning opportunities provided is not considered exhaustive. Trainees are encouraged to add and substitute other activities and learning experiences that will assist them in achieving the learning outcomes stated under each role section. Refer to the notes on learning portfolios for further information on possible learning opportunities. While participating in the suggested learning opportunities the trainee should focus on the development of learning outcomes listed in the relevant section. Supervisors may use the learning outcomes to help direct the trainee to appropriate learning opportunities and also to assess whether trainees are reaching the expected standards of achievement. More specific information about how different sections of the curriculum relate to one another is found under the Medical Expert role. The level of required knowledge or skill is specified for each learning outcome or group of outcomes in the Medical Expert role. Where learning outcomes in a group are all at the same level, the notation is shown next to the subheading; where they differ, it is given next to individual learning outcomes. For the remaining (nonMedical Expert) CanMEDS roles, the level of achievement is represented by the ability to perform the specified activities independently i.e. [I] Within each Radiation Oncologist role, the learning outcomes are followed by a set of suggested learning opportunities or activities, which will assist individual © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 15 CURRICULUM INTRODUCTION HOW TO USE THIS CURRICULUM DOCUMENT Page 16 © 2012 RANZCR. Radiation Oncology Training Program Curriculum MEDICAL EXPERT MEDICAL EXPERT © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 17 Page 18 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Role 1: Medical Expert Central to the role of the Radiation Oncologist is the interaction with the person with cancer. The Radiation Oncologist: •Synthesises oncological knowledge with clinical information to formulate and convey a plan of management •Applies technical expertise in carrying out planning and delivery of management programs, in particular those involving radiation therapy •Devises and conducts an effective program of patient assessment throughout and beyond initial treatment •Coordinates psychosocial and physical care during the follow up period, including delivery of further courses of radiation therapy and management of other cancer and treatment-related problems The learning objectives for the Medical Expert role are encompassed in two major sections of this curriculum, namely: 1.The Oncology Sciences 2.The Radiation Oncology Central Knowledge and Skills Summary (ROCKSS) and the Medical Expert Supplements (MES) ROCKSS and MES Oncology Sciences Within ROCKSS, these principles are not linked to individual tumour sites or specific clinical situations. Rather, the learning objectives contained within ROCKSS deal in a comprehensive manner with the processes of: 1.Assessment of patients a Radiation Oncologist will see throughout the course of their practice, leading to the establishment of a suitable management plan 2.Delivery and evaluation of this individualised management plan, both from the perspective of holistic patient care through and beyond treatment, and in relation to technical aspects of treatment delivery The Oncology Sciences section comprises the subjects considered fundamental to the clinical practice of Radiation Oncology, namely: • Radiation Oncology Physics • Radiation and Cancer Biology •Anatomy •Pathology Knowledge in these subjects at a foundation level is considered necessary in order to attain the skills and knowledge required for their clinical application. The latter, more complex, applied competencies will be developed in an ongoing, progressive manner throughout the full length and breadth of the training program. Consequently, where possible, learning outcomes for these subjects are organised into: • Phase 1 • Phase 2 This has been done to guide the trainee in prioritising study in these subjects. It is important to recognize however that all of the knowledge acquired in Phase 1 of the Oncology Sciences is relevant to Phase 2 training and the clinical application of this knowledge is examinable in the Phase 2 examination. © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKSS provides an overview of the clinical competencies required by the Radiation Oncologist at the time of completion of their training. This provides a detailed framework for the scope of Radiation Oncology training and practice. Medical Expert Supplements direct the trainee’s learning in relation to specific tumour sites and clinical situations. It is essential that these be used in conjunction with the ROCKSS, Pathology and Anatomy documents. The MES aim to focus the trainee on issues and areas of study that are in some way particular or unique to the topics. The ROCKSS competencies, however, form the core requirements for all topics covered by the MES and listed in the Table of Medical Expert Supplement Topics. The Table of Medical Expert Supplement Topics organises cancer topics into those in which Radiation Oncologists commonly play a central role in patient care and Page 19 MEDICAL EXPERT Role Statement management (major focus) and those in which Radiation Oncologists play a more supportive role (lesser focus). Topics are displayed and grouped for ease of reference and not in order of priority for study. It is recognised that the list of topics is not exhaustive and that the Radiation Oncologist may be rarely called upon to treat other diseases, and in these situations would base their management plan on relevant learning outcomes in ROCKSS. Page 20 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Radiation Oncology Physics inextricably underpins the practice of Radiation Oncology. Continuous learning in this subject from the start of training throughout the program and beyond is critical to effective and safe practice in this discipline. Much of the material below overlaps with the learning objectives contained within the ROCKSS and MES sections of the curriculum, as a detailed understanding of the physics of radiation and its application in the clinical setting is central to the Medical Expert role. Competencies (knowledge and skills) required within this subject in Phase 1 will be assessed through the Foundation Modules, Clinical Assignments and Phase 1 examination. Due to the importance of Radiation Oncology Physics all components learnt in Phase 1 will be assessable during Phase 2. In addition, during Phase 2 of training learning in Radiation Oncology physics will be extended. Radiation Oncology Physics and its clinical applications will be assessed through completion of Case Reports and within all components of the Phase 2 examination, in particular the planning examination and other viva components. PHASE 1 1Radiation and interactions with matter [D] The trainee is able to: 1.1 D escribe the fundamentals of an atom in terms of: 1.1.1 S tructure - nucleus, orbital shells, energy levels, binding energy 1.1.2 P articles - proton, neutron, electron, positron 1.1.3 D escription - atomic number, atomic weight, isotope, isomer 1.1.4 E nergy - conservation of mass and energy, mass-energy conversion 1.2 Describe the processes involved in photon absorption, scattering processes and electron interactions in terms of: 1.2.1 P hoton interactions i.e. coherent (elastic) scattering, photoelectric effect, Compton © 2012 RANZCR. Radiation Oncology Training Program Curriculum scattering, pair production, annihilation radiation, characteristic radiation, photonuclear reactions 1.2.2 Processes of attenuation: exponential attenuation, energy transfer, energy absorption 1.2.3 Interaction coefficients: coefficients of attenuation, energy transfer and absorption (in relation to relative importance of interactions in photon beam therapy) 1.2.4 Electron interactions: ionisation, excitation, heat production, radioactive interaction (bremsstrahlung), relative rate of energy loss and directional changes through collisional and radioactive processes, stopping power, range, scattering power, linear energy transfer 1.3 Describe the basic principles of X-ray production in terms of: 1.3.1 Bremsstrahlung and characteristic radiation production by electron bombardment 1.3.2 Efficiency of x-ray production and its dependence on electron energy and target atomic number 2Fundamental radiation quantities and units [G] The trainee is able to define and give units for: 2.1 Absorbed dose, kerma, equivalent dose, effective dose, attenuation coefficient 3Principles of image production and use in radiation therapy [D] The trainee is able to: 3.1 Describe the principles of imaging modalities used for treatment planning: 3.1.1 CT scanning 3.1.2 Plain film, fluoroscopy, MRI, ultrasonography, nuclear medicine imaging including PET [G] 3.2 Describe imaging techniques used to verify treatment accuracy e.g. port films, electronic portal imaging, cone beam CT Page 21 ONCOLOGY SCIENCES RADIATION ONCOLOGY PHYSICS 4External photon beam radiation therapy [D] The trainee is able to: 4.1 D escribe the construction of a linear accelerator, orthovoltage unit and superficial therapy unit and explain how a photon beam can be generated from each of these units 4.1.1 D iscuss how the beam aperture can be altered using Cerrobend blocking, multileaf collimators and independent jaws 4.1.2 D iscuss design and function of multileaf collimators including awareness of issues created by rounded leaf edges 4.1.3 D escribe the different types of wedge filters e.g. physical wedges and dynamic wedging 4.2 D escribe the construction of a Cobalt–60 unit and explain how a useful therapeutic radiation beam is generated from it [G] 4.3 D escribe the characteristics of kV and MV photon beams in terms of: 4.3.1 Intensity and angular distribution 4.3.2 B eam quality e.g. energy spectra, effective energy, half value layer 4.3.3 B eam variation e.g. change in characteristics with maximum electron energy, voltage, current and filtration as applicable 4.3.4 B eam edges and penumbra and their relation to beam energy 4.6 Define the following terms and discuss how each is used to calculate dose: tissue-air ratio, scatterair ratio, tissue phantom ratio, tissue-maximum ratio, output factor, back scatter factor, peak scatter factor, off-axis ratio, percentage depth dose [G] 4.7 Describe the effects on dose distribution of irregular or offset fields and the associated clinical implications of changes in beam aperture: compare and contrast the use of Cerrobend blocking, multileaf collimators and independent jaws 4.4 D escribe measurements of an external photon beam, including choice of suitable radiation detector, specifically: [D] 4.4.1 B eam measurement: radiation quality, output and inverse square law 4.4.2 M easurement protocols i.e. IAEA megavoltage absolute dosimetry protocol for megavoltage photon beams [G] 4.4.3 D ose distribution - kV and MV beam profiles, depth dose curves, construction of isodose charts 4.5 D escribe, with the aid of diagrams, the dose distribution in tissue produced by external beam photon radiation in terms of: [D] 4.5.1 R adiation components i.e. primary and scattered radiation Page 22 4.5.2 Descriptors of dose distribution i.e. percentage depth dose, beam profile, isodose charts, flatness and symmetry, penumbra, surface dose (entrance and exit) and skin sparing 4.5.3 Factors affecting dose distribution and beam output i.e. effects of field size and shape, source-skin distance, beam quality or energy; and beam modifying devices on dose distribution and beam output 4.5.4 Effects of tissue heterogeneity and patient irregularity i.e. effects on dose distribution of patient contour, bone, lung, air cavities and prostheses; and also dose within bone cavities, interface effects, effects of electronic disequilibrium 4.8 Discuss dose modification techniques in terms of: 4.8.1 Methods of compensation for patient contour variation and/or tissue inhomogeneity including wedging and compensating filters 4.8.2 Shielding of dose-limiting tissues 4.8.3 The use of bolus and build-up material 4.9 Describe and contrast the physical aspects of the following treatment techniques, namely: 4.9.1 Fixed SSD and isocentric techniques 4.9.2 Simple techniques: parallel opposed fields, multiple fields 4.9.3 Complex techniques: rotation therapy (full or partial), conformal therapy, IMRT 4.10 Describe the fundamental principles of Intensity Modulated Radiation Therapy and be able to distinguish features of step-and-shoot and dynamic deliveries including dynamic arcs © 2012 RANZCR. Radiation Oncology Training Program Curriculum 6.2 Display a working knowledge of current ICRU recommendations including definitions of the terms used in these documents and choice of prescription points or areas [D] 6.3 Describe and compare the processes of 2-D and 3-D planning [D] 6.4 Describe the principles of intensity modulated radiation therapy and inverse treatment planning [G] 6.5 Describe methods of determining body contour, location of internal structures including critical tissues and target volume including comparison of CT, MRI and PET [D] 6.6 Discuss the choice of beam energy, field size, beam arrangement and the use of bolus [D] The trainee is able to: 5.1 E xplain how an electron beam can be generated from a linear accelerator 5.2 D escribe the characteristics of an electron beam – energy spectra, energy specification, variation of mean energy with depth, photon contamination 5.3 D emonstrate a basic understanding of the difference between electron and heavy charged particle (in particular proton) interaction with matter 5.4 D escribe the assessment of electron beam radiation, including choice of suitable radiation detector, specifically: 5.4.1 Beam measurement: radiation quality, output 5.4.2 Measurement protocols i.e. the IAEA megavoltage dosimetry protocol for mega electron volt (MeV) electron beams [G] 5.5 D escribe, with the aid of diagrams, the dose distribution in tissue from an electron beam in terms of: 5.5.1 Dose distribution i.e. percentage depth dose, beam profiles, isodose charts, flatness and symmetry, penumbra, surface dose 5.5.2 Effects of field size and shape, source-skin distance, energy, beam collimation on dose distribution and beam output 5.5.3 Effects of heterogeneity and patient irregularity i.e. effect on dose distribution of surface obliquity, air gaps, lung, bone, air filled cavities, external and internal shielding 6.7 Discuss the use of, and problems associated with, field junctions in terms of: [D] 6.7.1 Photon-photon junctions 6.7.2 Photon-electron junctions 6.7.3 Electron-electron junctions 5.6 D iscuss methods of field shaping for different beam energies and the effect on surface dose 6Treatment planning and delivery for photon and electron beams The trainee is able to: 6.1 D iscuss different equipment and methods for patient simulation [D] © 2012 RANZCR. Radiation Oncology Training Program Curriculum 6.8 Discuss the process involved in calculation of monitor units and/or treatment time [G] 6.9Discuss dose calculation algorithms including Clarkson (including equivalent tissue-air ratio corrections), superposition/convolution, Monte Carlo and pencil beam methods, their comparative advantages and limitations [G] 6.10 Describe the accuracy of treatment planning and delivery in terms of: 6.10.1 Methods of patient monitoring and ensuring reproducibility of patient positioning throughout treatment and planning including immobilisation methods, treatment set-up, lasers, portal imaging [D] 6.10.2 Image-guided radiation therapy, including the use of cone beam CT and fiducial markers [G] 6.10.3 Tolerance levels for field shift 6.10.4 Consistency of patient contour and position of normal and tumour tissues during the course of treatment [D] Page 23 ONCOLOGY SCIENCES 5 Electron beam radiation therapy [D] 6.10.5 Accuracy of calibration, stability of beam parameters, accuracy of isodose calculation [G] 6.10.6 Determination of mechanical and radiation accuracy of treatment machines and simulators including the light field, cross-wire images, optical distance indicators [G] 6.10.7 Systematic and random errors [D] 6.10.8 Avoidance and detection of dose delivery errors including record and verify systems, select and confirm procedures, and interlocks [D] 6.10.9Potential errors arising from computer control of set up and treatment machine operation [G] 6.10.10In-vivo dosimetry techniques [D] 7 Radiation Measuring Devices The trainee is able to: 7.1 R ecognise and describe the principles of operation of radiation measuring devices 7.1.1 Ionisation chambers, semi-conductor detectors eg diodes and MOSFETs, thermoluminescent and optically stimulated luminescence dosimeters (TLDs and OSLs) [D] 7.1.2 P hotographic film, radiochromic film, Geiger-Muller counters, scintillation counters, chemical dosimeters [G] 7.2 D iscuss the use of radiation phantoms and dedicated dosimetry tools for fixed SSD and isocentric patient treatments [D] 8Radioactivity The trainee is able to: 8.1 Describe radioactivity in terms of: [D] 8.1.1 R adionuclide decay processes e.g. alpha, beta, positron, gamma, electron capture, internal conversion 8.1.2 R adionuclide production e.g. natural and artificial radioactivity, [G] 8.1.3 E xponential radioactive decay e.g. decay constant, half life (physical, biological, effective), mean life, daughter products, radioactive equilibrium Page 24 8.2 Define the term and give units for: [G] Activity, apparent activity, specific activity, air-kerma rate constant and reference air-kerma rate 9Fundamentals of sealed source radionuclides and brachytherapy The trainee is able to: 9.1 Discuss the radioactive sources used in sealed source brachytherapy in terms of: 9.1.1 Construction: source construction, including filtration [G] 9.1.2 Properties: spectra of radiation emitted, half-life, usual specific activity [D] 9.1.3 Measurement of source activity and dose rates, choice of suitable detectors and calibration [G] 9.1.4 Clinical decision-making: compare the advantages of radionuclides in various clinical circumstances [D] 9.1.5 Commonly used: caesium-137, iridium-192, iodine-125, palladium-106, strontium-90 [D] 9.1.6 Historical and less commonly used: radium-226, cobalt-60, yttrium-90 [G] 9.1.7 Management: handling, cleaning, inspection, storage and transport [G] 9.2 Describe sealed source brachytherapy in terms of: [D] 9.2.1 Types of procedures: surface applications, eye plaques, interstitial implants, intracavitary techniques 9.2.2 Source Dose Rate: low, medium, high and pulsed dose rate 9.2.3 Dose distributions: compare isodoses surrounding ideal sources and clinical sources 9.2.4 Delivery techniques: remote afterloading machines, manual afterloading 9.2.5 ICRU dose specification system: current ICRU recommendations for interstitial and gynaecological treatment specifications 9.2.6 Current dosage systems: Paris system, production of conformal dose distributions using a single, stepping source 9.2.7 Procedures for beta emitters: surface and ophthalmic applications, intravascular techniques, techniques of delivery – unique applicators and methods of use [G] © 2012 RANZCR. Radiation Oncology Training Program Curriculum 10 Unsealed source radionuclide therapy 10.2 D efine physical, biological and effective half life [D] 10.3 D iscuss methods of dose estimation: the Medical Internal Radiation Dose (MIRD) and other methods of estimating dose to target tissues and critical organs [G] 10.4 D iscuss the radioactive sources used in unsealed source therapy in terms of: 10.4.1 P roperties: spectra of radiation emitted, half-life, physical form and technique of delivery to patient and use in clinical practice [D] 10.4.2 M easurement of activity and dose rates [D] 10.4.3 C ommonly used: Iodine-131, strontium-90, samarium-153 [D] 10.4.4 L ess commonly used: phosphorus-32, yttrium-90 [G] 10.4.5 M anagement: safe handling, storage, transport, clean up of spills [D] 11 Radiation protection [D] The trainee is able to describe and demonstrate understanding of: 11.1 The ALARA Principle, Radiation Incident and Radiation Accident 11.6 Evaluate the practice of radiation protection in terms of: 11.6.1 Working procedures for use with radiation sources including simulators, CT, external beam therapy, brachytherapy and unsealed sources 11.6.2 Minimisation of dose to patients, staff and general public including safety procedures for staff, control of areas and radiation sources, radiation protection surveys, personal monitoring, area monitoring, construction of rooms to house sources and radiation generators 11.7 Recommended dose limits for foetal exposure and the human data from which these have been derived 11.8 Documentation and reporting requirements relating to radiation incidents and accidents PHASE 2 1Applied external photon beam radiation therapy [D] The trainee is able to: 1.1 Discuss the clinical advantages and disadvantages of intensity modulated radiation therapy 1.2 Appreciate the differences between stationary field and rotational (arc) IMRT, the latter usually referred to as VMAT. 1.3 Discuss and compare image-guided radiation therapy techniques 1.4 Interpret 3-D rendering and dose-volume histograms 1.5 Discuss the physical aspects of total body irradiation 11.5 Medical exposure in contrast to exposure of the 1.6 Describe the physical aspects including limitations of stereotactic radiosurgery and fractionated stereotactic radiation therapy © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 25 11.2 ICRP recommended dose limits; the basis for international recommended limits; specific ICRP and national radiation protection standards, regulatory frameworks in Australia and New Zealand (as applicable) 11.3 P ractical dose minimisation practices and procedures (time, dose, distance, shielding) 11.4 Typical environmental dose levels and doses from diagnostic medical exposures ONCOLOGY SCIENCES The trainee is able to: 10.1 D iscuss the concepts of uptake, distribution and elimination [D] public and occupational exposure (justification, optimisation and dose limits) in terms of: 1.6.1 The hardware and software components of stereotactic equipment 1.6.2 S tereotactic planning principles i.e. the steps involved in quality assurance for stereotactic treatments, achievable target dose homogeneity and peripheral dose fall-off 2Applied electron beam radiation therapy [D] The trainee is able to: 2.1 S elect, compare and describe the physical aspects of treatment techniques in terms of: 2.1.1 S imple techniques: single fields, multiple adjacent fields, multiple energy 2.1.2 S pecialised techniques: electron arc therapy, total skin electron irradiation [G] 5Selection of an appropriate modality and technique to solve clinical problems [D] The trainee is able to: 5.1 Select and justify the choice of treatment modality and technique for specific clinical circumstances including choice of photons versus electrons; external beam versus brachytherapy; selection of beam arrangements and energies and choice of other technical parameters 3Applied sealed source radionuclides and brachytherapy [D] The trainee is able to: 3.1 Discuss sealed source brachytherapy in terms of: 3.1.1 C linical uses of surface applications, eye plaques, interstitial implants, intracavitary techniques 3.1.2 Selection of source dose rate: low, medium, high and pulsed dose rate 3.1.3 P lanning: methods of reconstruction and dosage calculation using radiography, CT, MRI and US 3.1.4 ICRU dose specification system: current ICRU recommendations for interstitial and gynaecological treatment specifications 3.1.5 C urrent dosage systems: Paris system, production of conformal dose distributions using a single, stepping source 5.2 Discuss the modifications to technique and dosimetry, and quality assurance issues that may apply to pregnant patients receiving radiation to non-abdominal sites 6Commissioning and quality assurance of external photon and electron beam radiation therapy equipment [G] The trainee is able to: 6.1 Discuss the process of acceptance testing, including the mechanical, optical, radiation and safety considerations 6.2 Discuss the process of commissioning including data acquisition and establishment of baseline values for quality management of equipment installation 6.3 Discuss quality assurance relating to radiation therapy equipment including mechanical, optical and radiation parameters for quality management including frequency of testing 6.4 Exhibit an understanding of the concept of tolerances and action levels in relation to quality assurance measures 4 Proton beam radiation therapy [G] The trainee is able to: 4.1 D escribe the production of proton beams for clinical use including the key principles and advantages of the cyclotron and synchrotron 4.2.1 Beam profile and percentage depth dose 4.2.2 Clinical modification of Bragg peak and beam collimation 4.2.3 Beams produced by passive scattering foils and active scanning 4.2 D escribe, including graphical presentation, the dose distribution in tissue produced by proton beam radiation in terms of: Page 26 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Knowledge of radiation and cancer biology is an essential component of the decision-making process used by practicing Radiation Oncologists. This knowledge has been developed through careful clinical observation, laboratory investigation and rigorous clinical trials. Thus, an awareness of its historical evolution is an important foundation to understanding modern radiation and cancer biology. Continuous learning in this subject throughout the training program is critical to effective and safe practice. Knowledge required within this subject in Phase 1 will be assessed through the Foundation Modules, Clinical Assignments and Phase 1 examination. Due to the importance of radiation and cancer biology, all components learnt in phase 1 will also be relevant to Phase 2 learning. Radiation and cancer biology and its clinical applications will be assessed in Phase 2 through completion of Case Reports and within components of the Phase 2 examination. The Radiation and Cancer Biology curriculum overlaps with the Pathology curriculum. The two should be considered in conjunction rather than as independent entities. PHASE 1 1 Historical background (G) The trainee is able to: 1.1 D escribe the early empirical observations of the effects of ionizing radiation, including: 1.1.1 The anti-proliferative effect 1.1.2 The relationship between radiosensitivity and cellular reproductive activity: “Law of Bergonie and Tribondeau” 1.2 D escribe the developments leading to the understanding of the therapeutic ratio, including: 1.2.1 The recognition and quantification of normal tissue injury 1.2.2 The distinction between acute and late reactions 1.2.3 The notion of treating to ‘tolerance’ © 2012 RANZCR. Radiation Oncology Training Program Curriculum 1.3 Describe the evolution of fractionated treatment, including: 1.3.1 The ram’s testis experiment 1.3.2 The demonstration of clinical cures with fractionated external radiation treatment 1.3.3 The adverse effect of treatment protraction 1.3.4 The evolution of “standard” fractionation schedules 2Normal cell structure and functions relevant to neoplasia (G) The trainee is able to discuss: 2.1 Normal cell structure 2.2 The structure of eukaryotic genes e.g. open reading frame, untranslated regions, introns, exons, regulatory elements 2.3 Chromosome packaging 2.4 DNA replication and the importance of maintaining genomic integrity 2.5 RNA transcription and translation 2.6 Epigenetic effects on gene expression 2.7 The cell cycle 2.7.1 Cell cycle phases and functions 2.7.2 Checkpoints and their molecular controls 2.7.3 Major cell cycle regulators e.g. pRB, p53, cyclins, cyclin-dependent kinases 2.7.4 Cell cycle kinetic parameters 2.8 Physiological controls of the cell cycle 2.8.1 Extra cellular agents affecting cell growth / survival e.g. growth factors, hormones 2.8.2 Growth factor receptors 2.8.3 Signal transduction e.g. MAPK/ERK, RAS, RAF pathways 2.9 Changes in the physiological controls that occur in, or promote oncogenic transformation 2.9.1 Over-expression of EGF 2.9.2 EGFR mutation and up-regulation 2.9.3 Autonomous functioning of signal transduction pathways 2.9.4 HPV mediated loss of p53 and pRB function Page 27 ONCOLOGY SCIENCES RADIATION AND CANCER BIOLOGY 3Mechanisms of malignant cell transformation and progression (G) The trainee is able to discuss: 3.1 Activation of oncogenes/loss of tumour suppressor genes 3.1.1 M echanisms including point mutations. insertions, deletions, translocations, and amplifications 3.1.2 M ethods of quantification including comparative genomic hybridization, in-situ hybridization and spectral karyotyping 3.1.3 Stable and unstable aberrations 5Radiation-induced cellular damage (D) The trainee is able to discuss: 5.1 The evidence for DNA being the clinically relevant target for cell killing (G) 5.2 Other targets of radiation damage 5.3 Types of DNA lesions caused by ionising radiation including double strand breaks (DSB), single strand breaks (SSB), cross links and base damage 5.4 DNA damage repair mechanisms including sublethal damage and potentially lethal damage 3.3 Epigenetic and telomeric changes 3.3.1 G lobal demethylation, promoter hypermethylation 3.3.2 Aberrant histone acetylation 5.5 Assays for DNA damage including: g-H2AX, Comet assay, pulsed field electrophoresis, plasmid based assay, micronucleus assay and chromosomal aberrations (G) 3.4 Models of tumour initiation and progression 5.6 Radiation sensitivity in different phases of the cell cycle 3.5 In vitro characteristics of transformed and malignant cells 5.7 Modes of cell death including timing of cell death and relative importance following ionising radiation including: mitotic catastrophe, apoptosis, radiation-induced senescence, necrotic death, autophagy 5.8 Concepts of reproductive death and clonogenicity 5.9 The bystander effect 5.10The titration of radiation dose according to tumour cell ‘burden’ including macroscopic versus microscopic disease (G) 3.2 Knudson’s 2-hit hypothesis 3.6 Tumour angiogenesis and vasculogenesis 3.7 Steps in the metastatic cascade 4 Tumour growth (D) The trainee is able to discuss: 4.1 G ompertzian growth of untreated cancers including the concepts of: 4.1.1 Tumour doubling time (TD) 4.1.2 Potential doubling time (Tpot) 4.2 Determinants of tumour growth rate including 4.2.1 Cell cycle time (Tc) 4.2.2 Growth fraction (GF) 4.2.3 Cell loss factor 4.3 The effect of tumour microenvironment on growth rate 4.4 The concept and mechanism of accelerated repopulation following radiation Page 28 6 DNA double strand break repair (D) The trainee is able to discuss: 6.1 Processes involved in the DNA double strand break (DSB) repair response including: 6.1.1 Sensing DNA DSB 6.1.2 Cell cycle arrest 6.1.3 Histone modifications 6.1.4 Recruitment of DNA DSB repair proteins 6.1.5 DNA DSB repair pathways 6.1.6 Homologous recombination and Non-homologous end-joining © 2012 RANZCR. Radiation Oncology Training Program Curriculum 6.2 The genetic diseases that affect DNA repair/ clinically apparent radio-sensitivity (eg. ataxia telangectasia) 7Quantifying cell survival following irradiation (D) The trainee is able to discuss: 7.1 The concept of cell survival curves 9The linear quadratic dose response and the α/β ratio in clinical practice (D) The trainee is able to discuss: 9.1 Relationship between dose/fraction and tissue α/β ratio 9.2 Effect of incomplete repair between fractions 7.2 In-vitro and in-vivo techniques to generate survival curves 7.3 Dose rate effects on cell survival 7.4 The linear quadratic formula in terms of: 7.4.1 The biophysical basis of α and β in the linear quadratic formula 7.4.2 Clinically derived α/β ratios for: 7.4.2.1 Different types of cancer 7.4.2.2 Acute and late responding normal tissues 7.4.3 Limitations of the linear quadratic formula e.g. do not apply to high radio-ablative doses per fraction 8 Fractionation and the ‘5 Rs’ (D) The trainee is able to discuss: 8.1 The ‘5 Rs’ of fractionation and their significance in clinical practice 8.1.1 Intrinsic Radiosensitivity 8.1.2 Repair 8.1.3 Reoxygenation 8.1.4 Redistribution 8.1.5 Repopulation 8.2 The definition and rationale for non-standard fractionation schedules including: 8.2.1 Hyperfractionation 8.2.2 Accelerated fractionation 8.2.3 Hypofractionation 9.3 Biological Effective Dose (BED) and use the appropriate formula to 9.3.1 Calculate iso-effective doses for different fractionation schedules 9.3.2 Calculate partial/residual tolerance of normal tissues 9.3.3 Correct BED for tumour cell proliferation 9.4 The meaning and impact of the ‘double trouble’ phenomenon 9.5 Dose rate effects in brachytherapy 10 Hypoxia and the oxygen effect (D) The trainee is able to discuss: 10.1 Modification of radiation-induced DNA damage by oxygen 10.2 The Oxygen Enhancement Ratio (OER) 10.3 Evidence supporting the clinical significance of tumour hypoxia 10.4 Methods used to overcome the effect of tumour hypoxia including their rationale: e.g. fractionation, hypoxic cell sensitisers, hypoxic cell cytotoxins, hyperbaric oxygen, high LET radiation, and hyperthermia 10.5 Tumour responses to hypoxia occurring at the molecular level including: the role of transcription factor HIF1-α and its effect on tumour metabolism, pH vasculature, and angiogenesis (G) 10.6 Consequences of molecular responses to hypoxia including: angiogenesis, increased propensity for metastasis and genetic instability (G) 8.3 The reasons behind the differences in ‘typical’ fraction schedules employed for curative versus non-curative (palliative treatments) including differences in treatment aim, differing concern re late toxicity, dose required to achieve an effect © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 29 ONCOLOGY SCIENCES 11 Radiation Quality (D) The trainee is able to discuss: 11.1 Types of ionising radiation 11.2 L inear energy transfer (LET) and its relationship to direct and indirect DNA damage, free radicals and free radical scavengers 13.3 Functional sub units and the volume effect on: 13.3.1 Parallel arrangement of functional sub units 13.3.2 Series arrangement of functional sub units 13.4 Flexible and hierarchical kinetic models (G) 13.5 The abscopal effect (G) 13.6 Post radiation regeneration of normal tissues 13.7 The concept of normal tissue/organ tolerance 13.8 How the relationship between tolerance dose and irradiated volume was determined 11.3 Relative biological effectiveness (RBE) 11.4 The relationship between LET and OER 12 Dose response for tumour control (D) The trainee is able to discuss: 12.1 Shape of the dose-response curve 12.2 The determinants of the steepness of the dose-response curve 12.3 The concept and significance of the Therapeutic Ratio 12.4 Concepts of radiocurability and radiation responsiveness 12.5 Major factors influencing tumour control 12.5.1 P hysical Factors including dose, dose rate, radiation quality, temperature 12.5.2 C hemical Factors including oxygen, radiosensitizers and radio-protectors 12.5.3 B iological Factors including cell type and radiosensitivity, clonogen number, host factors 12.5.4 Technical Factors including geographic miss 12.6 Tumour control probability curves 13Effects of radiation on normal tissues (D) 13.9 The mechanism of effect and consequences of radiation on: 13.9.1 Parenchymal tissues 13.9.2 Connective tissue 13.9.3 Vascular systems 13.9.4 The immune system 13.10 Acute syndromes following high doses of total body radiation 13.10.1 Acute radiation syndrome 13.10.1.1 Prodromal period 13.10.1.2 Latent period 13.10.1.3 Manifest Illness (Critical Phase) 13.10.1.4 Recovery or death 13.10.2 Cerebrovascular syndrome 13.10.3 Haematological syndrome 13.10.4 Gastrointestinal syndrome 13.11 Methods of biological dosimetry for unplanned / uncontrolled radiation exposure including: blood counts, chromosome aberrations in peripheral blood lymphocytes (dicentric assay, translocation assay), g-H2AX, mitotic index, micronucleus and comet assays [G] The trainee is able to discuss: 13.1 Acute, sub-acute and late toxicity from radiation 14Effects of radiation on the human embryo and foetus (D) The trainee is able to discuss: 14.1 The major phases of foetal development, including CNS growth and corresponding gestational age 13.2 The meaning of latency with regard to normal tissue effects Page 30 © 2012 RANZCR. Radiation Oncology Training Program Curriculum 14.2 The nature of and reasons for effects caused in utero 14.3 F actors influencing effect type and risk including dose and stage of gestation 17.3 Mechanisms of cytotoxic enhancement by chemotherapy eg, independent action, additive and synergistic interactions 17.4 Biological cooperation e.g. hypoxic cell sensitisers and cytotoxins 17.5 Temporal modulation e.g. EGFR blockade, endocrine agents 17.6 Spatial cooperation including the concept of ‘sanctuary sites’ 17.7 Normal tissue protection 17.8 The impact on acute and late side effects arising from combining radiation with other treatments 14.4 The definition of doubling dose 15Quantification of radiation effects on normal tissues (G) The trainee is able to discuss: 15.1 P rinciples of toxicity scoring systems used in current clinical practice including selection of appropriate endpoints and quantification 15.2 E xamples of toxicity scoring systems used in current clinical practice e.g. RTOG, Common Toxicity Criteria, LENT/SOMA 15.3 Tolerance doses of normal tissues/organs including the QUANTEC data and its limitations 16 Radiation carcinogenesis (D) The trainee is able describe: 16.1 The shape of the dose-response curve for this effect including the peak for leukaemias but not for solid tumours 18Retreatment with radiation therapy (D) The trainee is able to discuss: 18.1 The radiobiological principles for consideration of re-treatment including; initial radiotherapy dose (EQD2), volume, volume of overlap, technique used 18.2 The effect of radiation modifiers used in treatment of the first tumour e.g. concurrent chemotherapy 18.3 Time interval between therapy courses and concept of forgotten dose 18.4 The re-irradiation tolerance of normal tissues derived from experimental and clinical studies for both early and late effects. 16.2 Threshold versus non-threshold uncertainty 16.3 Assumptions and recommendations for dose limits in radiation protection 16.4 R elevance of integral dose in radiotherapy to second cancer induction risk 17Combination of radiation with other therapies (D) The trainee is able to discuss: 17.1 The radiobiological basis and rationale for combining surgery and radiation in the preoperative, postoperative and intra-operative settings 17.2 C ombining systemic therapies with radiation, including: 17.2.1 The rationale and sequencing of therapies PHASE 2 19Specialised radiation therapy techniques (D) The trainee is able to describe: 19.1 The radiobiological principles as they relate to brachytherapy including low dose rate, high dose rate and pulsed treatments © 2012 RANZCR. Radiation Oncology Training Program Curriculum 19.2 The radiobiological principles and implications of specialised methods for external beam Page 31 ONCOLOGY SCIENCES radiation delivery including ablative stereotactic radiosurgery and radiation therapy, tomotherapy, intensity-modulated radiation therapy (IMRT) and charged particle therapy 21.7 RNA interference (RNAi) 21.8 Tissue microarrays (TMAs) 21.9 In-situ hybridisation e.g. fluorescent in-situ hybridisation (FISH), chromogenic in-situ hybridisation (CISH) 21.10 Systems biology and bioinformatics including definitions, and application to DNA microarrays and proteomics 20Further application of cancer biology to systemic therapy (G) The trainee is able to discuss: 20.1 A classification of systemic agents including: cytotoxic chemotherapy, endocrine therapy, cell membrane receptor blockers, cell signalling pathway inhibitors and radio-sensitisers and protectors 20.2 The mechanism of action of commonly used systemic therapies including phase specific and cell cycle specific agents 20.3 C ommon molecular targets for therapy e.g. angiogenesis, signal transduction, DNA repair, apoptosis and examples of therapies directly at these targets 20.4 Individualisation of systemic treatments based on molecular features 21 Molecular analysis in oncology (G) The trainee is able to discuss in general terms the methods for and examples of usage of: 21.1 N ucleic acid hybridisation including Northern and Southern analysis, DNA microarrays, competitive genomic hybridisation (CGH) 21.2 P rotein analysis: Western analysis, immunoprecipitation, immunohistochemistry, proteomics (2-dimensional gels, mass spectrometry) 21.3 P CR(polymerization chain reaction), quantitative RT-PCR 21.4 D NA sequencing 21.5 D etection of single nucleotide polymorphisms (SNPs), mutations in tumours 21.6 K nockout, knockin and transgenic mice Page 32 ANATOMY These learning outcomes should be used as a guide to studying anatomy from an oncological perspective. A comprehensive knowledge of anatomy in relation to cancer medicine allows an oncologist to interpret a given clinical situation or individual presentation in order to formulate a diagnosis and to devise a management plan. In addition, a good knowledge of anatomy is crucial to the accurate delivery of a course of radiation therapy and to the process of defining organs and regions as part of the treatment planning process. Knowledge of anatomy of all sites will be required by the completion of Phase 1 of Radiation Oncology training. Competencies (knowledge and skills) required within this subject in Phase 1 will be assessed through the Foundation Modules, Clinical Assignments and Phase 1 examination. Due to the importance of anatomy all components learnt in phase 1 will be assessable during Phase 2. Anatomy and its clinical applications will be assessed through completion of Case Reports and within components of the Phase 2 examinations. PHASE 1 The aim of anatomy study and assessment in Phase 1 will be to ascertain that the trainee is developing an oncological approach to this subject and has competence when applying anatomical principles to the management of cancer patients. To guide learning, the organs and structures relevant to the management of commonly encountered tumour sites are listed in the following table. © 2012 RANZCR. Radiation Oncology Training Program Curriculum 1 L ocation of the structure or organ, including definition of boundaries and normal variations between individuals 7 “Critical” and clinically-relevant tissues and anatomical regions related to the structure, organ or tumour under study e.g. supraclavicular fossa for breast cancer, rectum for prostate cancer 8 Landmarks (surface body, radiological, other imaging techniques) 9 Neurological pathways and major arterial supply and venous drainage to organs and structures, especially those which impact on radiation planning and treatment decisions 10 Lymphatic drainage of organs and structures including major nodal stations 11 Important deviations from “normal” anatomy, either developmental or arising from iatrogenic causes 2N atural variations occurring in a person in relation to normal body functions e.g. respiration 3 In vivo (macroscopic) appearance of structure or organ 4N ormal histology (microscopic appearance) of the organ 5 Appearance of structure or organ on relevant imaging modalities 6 Routes of potential cancer spread, including: 6.1 Local planes/direct spread 6.2 Lymphatic spread 6.3 Haematogenous 6.4 Transcoelomic 6.5 Neurological 6.6 Iatrogenic Phase 1 Anatomy Topics Neuro-anatomy Functional and anatomical compartments of the cerebrum and cerebellum. Brainstem Ventricular system Cranial nerves including their origin and distribution (intra and extra cranial) Spinal cord and cauda equina Meninges Brachial plexus Sacral plexus Innervation of the upper and lower limbs Autonomic nervous system Head and neck anatomy Nasopharynx Oropharynx Oral cavity Tongue Paranasal sinuses Major salivary glands Larynx Hypopharynx Thyroid gland Parathyroid glands Pituitary gland Orbits Paranasal/facial sinuses Course and relations of the internal and external carotid arteries and their major branches bilaterally © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 33 ONCOLOGY SCIENCES For each anatomical site or organ listed, the trainee is able to discuss and demonstrate the: Head and neck anatomy cont. ourse and relations of internal and external jugular veins and their major C tributaries bilaterally Anterior and posterior triangles of the neck Supraclavicular fossa Pterygopalatine fossa Temporal and infratemporal fossae Base of skull including pituitary fossa, cavernous sinus, Meckel’s cave, Rathke’s pouch, clivus. All vascular and neural foramina for major vessels, cranial nerves and their branches traversing the base of skull Thoracic anatomy Mediastinum Trachea and main bronchi Lung Pleura and pleural cavities Heart and great vessels Azygos vein Oesophagus Thoracic course of the thoracic duct Breast Chest wall anatomy Pericardium Abdominal anatomy Stomach Duodenum Liver Spleen Gall bladder and billiary tract Pancreas Kidneys Adrenal glands Ureters Cysterna chyli and abdominal course of the thoracic duct Abdominal wall anatomy Pelvic anatomy Rectum Anal canal Bladder Male and female urethra Prostate Testes, epidydimis, vas deferens, seminal vesicles Penis Ovaries Fallopian tubes Uterus Cervix Vagina Vulva Upper and lower limbs Axilla Inguinal and femoral canals Dermatomes and myotomes of the upper and lower limbs Muscular compartments and major muscles of the limbs Page 34 © 2012 RANZCR. Radiation Oncology Training Program Curriculum PHASE 2 Knowledge and revision of all of the Phase 1 anatomy topics will be expected in Phase 2. For Phase 2 learning, the Medical Expert Supplement (MESs) may highlight learning outcomes specific to a particular tumour site or considered worthy of emphasis over and above the contents of the Phase 1 Anatomy curriculum. A trainee will be expected to demonstrate their anatomy knowledge through its clinical application, e.g. in the physical examination of a patient, making a suitable management decision based on natural history, interpretation of diagnostic imaging and in defining tumour and normal tissue volumes and doses during the radiation therapy planning process. Competencies (knowledge and skills) required within this subject in Phase 1 will be assessed through the Foundation Modules, Clinical Assignments and Phase 1 examination. Due to the importance of pathology all components learnt in Phase 1 will be assessable during Phase 2. Pathology will be further assessed through completion of Case Reports and within components of the Phase 2 examinations. PATHOLOGY These learning outcomes should be used as a guide to studying pathology from an oncology perspective. A comprehensive knowledge of pathology in relation to cancer medicine allows an oncologist to interpret a given clinical situation or individual presentation in order to formulate a diagnosis and to devise a management plan. Although some of the principles of cancer pathology will be learned or revised in the early part of Radiation Oncology training, the topic areas will be studied and assessed with increasing depth, breadth and application over the continuum of the program. Learning outcomes in Phase 1 are divided into two broad sections: • The biology of normal and cancer cell function and growth, on both microscopic and molecular levels • An introduction to the integration of pathology skills and knowledge into the management of patients with cancer In Phase 2, the additional learning outcomes are divided into two broad sections as well: • All aspects of pathology relating to site-based neoplastic processes (trainees should refer to the Medical Expert Supplement [MES] table to guide their study, and also refer to the specific MES which will highlight learning outcomes specific to a particular tumour site considered worthy of emphasis over and above the contents of the generic learning outcomes listed here) © 2012 RANZCR. Radiation Oncology Training Program Curriculum The Pathology curriculum overlaps with the Radiation and Cancer Biology curriculum. They should be considered in conjunction rather than as independent entities. PHASE 1 1 Introduction to cancer pathology [G] The trainee is able to describe and, where relevant, give examples of the: 1.1 Introduction to neoplasms [D] 1.1.1 Major histological types of cancer 1.1.1.1 Carcinoma 1.1.1.2 Sarcoma 1.1.1.3 Lymphoma 1.1.1.4 Melanoma 1.1.2 Typical cytological features of malignant cells as compared with those of normal cells 1.1.3 Typical biological behaviour of benign and malignant neoplasms 1.1.4 Neoplasia, differentiation, anaplasia, aneuploidy 1.1.5 Cancer stem cells and cancer cell lineages, monoclonality 1.1.6 Tumour heterogeneity 1.1.7 Pathways of spread 1.2 Molecular basis of cancer and cancer genetics 1.2.1 Molecular techniques [G] 1.2.1.1 Microarrays 1.2.1.2 Tissue arrays 1.2.1.3 RT-PCR 1.2.2 Dysregulations of cancer-associated genes [G] 1.2.2.1 Chromosomal changes Page 35 ONCOLOGY SCIENCES • An advanced application of pathology skills and knowledge into the management of patients with cancer, including working in a multidisciplinary team 1.2.2.2 Gene amplification 1.2.2.3 Epigenetic changes 1.2.2.4 Polymorphisms 1.2.3 Carcinogenesis [D] 1.2.3.1 Initiation and promotion 1.2.3.2 Molecular basis of multistep carcinogenesis including the Vogelstein model of colorectal carcinogenesis 1.2.3.3 Chemical, radiation and microbial carcinogenesis 1.2.3.4 Malignant transformation 1.2.3.5 Precursor lesions and field effect 1.2.4 Self-sufficiency in growth signals [D] 1.2.4.1 Proto-oncogenes, oncogenes, oncoproteins 1.2.4.2 Growth factors and growth factor receptors 1.2.4.3 Signal-transducing proteins 1.2.4.4 Transcription factors 1.2.4.5 DNA repair defects and genomic instability 1.2.5 Insensitivity to growth inhibition [D] 1.2.5.1 Tumour suppressor genes 1.2.5.2 Evasion of apoptosis 1.2.5.3 DNA repair defects and genomic instability 1.2.5.4 Limitless replicative potential: telomerase 1.2.6 Stromal microenvironment [G] 1.2.7 Mechanisms of invasion and metastasis [D] 1.2.8 Sustained angiogenesis [G] 1.3 Mechanisms of cell death 1.3.1 Apoptosis (in normal and tumour cells, morphological and biochemical features, molecular pathway leading to apoptosis e.g. Bcl-2, p53-dependent and independent pathways, ceramide) [G] 1.3.2 M itotic death (types, cell division post radiation and timing) [D] 1.3.3 N ecrotic death and radiation-induced senescence 1.3.4 O ther modes of death e.g. autophagy, entosis Page 36 1.4 Tumour immunology 1.4.1 Tumour antigens 1.4.2 Anti-tumour effector mechanism 1.4.3 Immune surveillance 2Pathology of Radiation damange in normal tissue [D] The trainee is able to discuss: 2.1 The pathogenesis and clinical manifestations of radiation injury to normal tissues/organs including neural tissue, skin, mucosa, bone, the eye, thyroid, lungs, heart, bowel, kidney, liver, testis, ovary 2.2 The concept of tolerance dose (including TD5/5 and TD 50/5) for specific tissues/organs 2.3 Patient related factors that affect normal tissue damage from radiation 3Introduction to Clinicopathological Integration [G] The trainee is able to describe: 3.1 The role of a pathologist in the multidisciplinary team, including within the laboratory 3.2 The general principles of laboratory diagnosis of malignancy 3.2.1 Biopsy methods 3.2.2 Handling of specimens 3.2.3 Histological analysis 3.2.3.1 Grading systems 3.2.3.2 Immunohistochemistry 3.2.4 Serum tumour markers 3.3 Staging and classification systems 3.3.1 TNM general principles and terminology 3.3.2 Commonly applied staging/ classification systems 3.4 How to interpret a pathology report including pathological prognostic factors © 2012 RANZCR. Radiation Oncology Training Program Curriculum 4 Pathology of Specific Cancers [D] For each tumour site and type listed in the Medical Expert Table or in the Medical Expert Supplements, the trainee is able to describe and discuss its: 4.1 Epidemiology (population statistics) 4.1.1 Incidence (in population) 4.1.2 Age (of onset) 4.1.3 Gender predilection 4.1.4 Geographical distribution 4.2 Aetiology (individual causative factors) and pathogenesis 4.2.1 Genetic/Chromosomal abnormalities 4.2.2 Environmental 4.2.3 Nonhereditary predisposing conditions 4.2.4 Associated familial cancer syndromes 4.3 Natural History 4.3.1 Precursor lesions 4.3.2 Field effect 4.3.3 Patterns of spread and biological behaviour 4.4 Clinical Presentation 4.4.1 Common symptoms and signs (link to pathology) 4.4.2 Effects of the tumour on the host 4.4.2.1 Paraneoplastic syndromes 4.4.2.2 Cancer cachexia 4.4.2.3 L ocal effects e.g. destructions of adjacent tissues, obstruction or compressions of hollow structures 4.4.2.4 Hormonal effects 4.4.3 Characteristic imaging findings (link to pathology) 4.5 Laboratory diagnosis of malignancy 4.5.1 M acroscopic appearance and growth patterns 4.5.2 M icroscopic appearance and growth patterns 4.5.2.1 Histological subtypes and classification 4.5.2.2 L ink to predicted biological behaviour © 2012 RANZCR. Radiation Oncology Training Program Curriculum 4.5.2.3 Laboratory methods, including frozen section analysis and electron microscopy [G] 4.5.2.4 Characteristic cellular appearance and architecture 4.5.2.5 Grading systems 4.5.2.6 Immunohistochemistry 4.5.2.7 Molecular techniques, chromosomal changes, flow cytometry 4.5.2.8 Uncertainty in microscopic diagnosis 4.5.3 Normal histology and structure of tissue of origin i.e. distinguish normal from pathological areas 4.5.4 Differential diagnosis i.e. other histologies to consider in relation to anatomical location 4.6 Staging and classification systems [D] 4.6.1 TNM principles and terminology 4.6.2 Commonly applied staging systems 4.6.3 Commonly applied classification systems 5Advanced Clinicopathological Integration [D] The trainee is able to: 5.1 Discuss the relationship between histological features, classification systems, grading systems, staging systems and predicted biological behaviour 5.2 Discuss the patient and tumour factors that influence tumour and normal tissue (toxicity) outcomes 5.3 Evaluate blood test results 5.3.1 Anaemia 5.3.2 Electrolyte disturbance 5.3.3 Liver enzyme abnormalities 5.3.4 Thromboembolic abnormalities 5.3.5 Tumour markers 5.4 Evaluate the optimal methods of obtaining a diagnosis of malignancy [G] 5.4.1 Biopsy methods – advantages and disadvantages for various types of cancer Page 37 ONCOLOGY SCIENCES PHASE 2 5.5 Work with pathologists as part of the multidisciplinary team 5.5.1 D escribe the role of pathologists in the cancer management team 5.5.2 C ommunicate effectively with pathologists regarding the pathological features that may influence diagnosis and treatment 5.5.3 D iscuss how to interpret a pathology report including pathologic prognostic and predictive factors 5.5.4 E valuate the advantages and disadvantages of synoptic reporting 5.5.5 D iscuss when second review of pathology specimen may be appropriate 5.6 D iscuss the difficulties and uncertainties of pathological diagnosis Page 38 © 2012 RANZCR. Radiation Oncology Training Program Curriculum 1Establishing a diagnosis and management plan As part of the process of arriving at and instituting an optimal plan for individualised patient management, the trainee is able to: 1.1 Assess the patient and the cancer 1.1.1 Obtain adequate information from the patient (history and physical examination) and relevant others to determine the probable diagnosis, the extent of the disease, other co-morbid conditions and other physical factors influencing decision making e.g. pregnancy 1.1.2 Identify and explore the patient’s issues, concerns and beliefs within the scope of a focussed consultation 1.1.3 Select and interpret investigations 1.2 D emonstrate an understanding of the TNM staging system and other commonly used disease-specific staging systems. Demonstrate knowledge of the specific TNM criteria used for cancer sites deemed as major focus within the MES Table (pg 42) 1.3 S ynthesise and justify treatment options based on current evidence, multidisciplinary advice and relevant patient-related factors including treatment intent 1.4 D iscuss with the patient (and others e.g. family) the natural history of the disease, prognosis, treatment options and recommendations, and devise a mutually agreed management plan (which may include situations where no anticancer treatment is involved) 1.5 E valuate patients for referral to other specialists (e.g. palliative care physician), and allied health professionals (e.g. dietician, clinical psychologist) 1.6 Adopt a holistic approach to care of the patient’s physical, psychological and cultural needs © 2012 RANZCR. Radiation Oncology Training Program Curriculum In relation to the process of delivery of treatment and follow-up of patients undergoing management of cancer (and other relevant diseases), the learning outcomes pertaining to each management area are listed in Sections 2 to 5. 2Where radiation therapy is part of the management plan The trainee is able to: 2.1 General 2.1.1 Describe the radiophysical and biological advantages, disadvantages and limitations of all radiation therapy modalities relative to each other for clinical treatment 2.1.2 Describe the quality assurance and safety issues of therapeutic radiation 2.1.3 Justify the intent of radiation treatment (e.g. cure, local control, prolongation of life, symptom palliation) and explain the rationale of sequencing of the treatment in relation to other treatment modalities 2.1.4 Arrange referrals prior to treatment (e.g. dentist, audiology, sperm bank) 2.1.5 Select modality(ies) of treatment relevant to the patient 2.1.6 Prescribe and supervise treatment 2.1.7 Describe the potential acute and late radiation toxicity associated with any given treatment plan 2.1.8 Explain, where relevant, how treatment decisions have been modified in relation to the pregnant patient The trainee is able to: 2.2 External beam (kilovoltage and megavoltage) 2.2.1 Supervise the patient treatment planning process, in particular to: 2.2.1.1 Justify appropriate patient positioning including use of any immobilisation, positioning or shielding devices 2.2.1.2 Choose an appropriate mode of simulation and where relevant use contrast media and/or markers that may aid in planning 2.2.1.3 Describe and use imaging modalities that may be employed by treatment planning systems, including image fusion Page 39 ROCKKS AND MES RADIATION ONCOLOGY CENTRAL KNOWLEDGE AND SKILLS SUMMARY (ROCKSS) 2.2.1.4 Review relevant histopathology, surgical reports and imaging, and use the information to devise an appropriate GTV/CTV/PTV/ITV or field size and identify relevant organs at risk 2.2.1.5 Define the target volumes to receive specific doses e.g. for intensitymodulated radiation therapy 2.2.1.6 Consider the likely treatment field arrangement and the need for build up material or beam modifiers 2.2.1.7 Communicate the above information to the radiation therapists involved in simulating and planning the patient 2.2.2 Prescribe a course of radiation treatment and in doing so: 2.2.2.1 Choose beam type and energy; where relevant choose Focus Skin Distance (FSD) and beam filter 2.2.2.2 Decide on reference dose, dose per fraction, number of fractions, and overall treatment time 2.2.2.3 Determine the optimal sequencing and timing of external beam therapy in relation to other treatments and interventions, particularly surgery, chemotherapy and brachytherapy 2.2.2.4 Specify tolerance dose of any organs at risk 2.2.2.5 Select, justify and approve the final treatment plan; central to this process is the ability to critically appraise treatment plans 2.2.3 Supervise a course of radiation treatment including: 2.2.3.1 Verification of treatment e.g. attend first treatment set-up, review portal images, image-guided radiation therapy 2.2.3.2 Review of patient during treatment; management of acute toxicities and radiobiological differences between manual loading, LDR after-loading and HDR after-loading methods 2.3.3 Explain, and demonstrate selection of, the target volumes for brachytherapy treatments 2.3.4 Explain the techniques of intracavitary, surface and interstitial brachytherapy, including quality assurance and safety checks 2.3.5 List and justify the steps in preparation for brachytherapy treatment, including patient set-up, sedation if required, management during the implantation period and radiation protection issues 2.3.6 Explain, compare and contrast the different methods of dose prescription for brachytherapy 2.3.7 Select and justify the dose prescription for brachytherapy treatments and dose limitations to relevant normal tissues 2.3.8 Apply relevant ICRU reporting principles to brachytherapy 2.3.9 Evaluate historical and contemporary results of brachytherapy treatments in terms of tumour control and toxicities The trainee is able to: 2.4 Radio-isotope therapy 2.4.1 List the common clinical applications of radio-isotope therapy and provide evidence for their efficacy 2.4.2 Describe the techniques of radio-isotope administration and explain the importance of radiation protection for unsealed sources 2.4.3 Select suitable patients for isotopes including criteria for their safe use (e.g. skeletal load and blood count thresholds for Strontium-89 and Samarium-153) 2.4.4 Discuss the expected outcomes from radioisotope therapy 2.4.5 Describe potential toxicities of isotope treatment and their management The trainee is able to: 2.3 Brachytherapy 2.3.1 List the clinical applications of intracavitary, surface and interstitial brachytherapy 2.3.2 D escribe and explain the physical, logistic Page 40 © 2012 RANZCR. Radiation Oncology Training Program Curriculum The trainee is able to: 3.1 E valuate the role of surgery in diagnosis and staging 3.2 Describe the principles of cancer surgery 4.6 Demonstrate understanding and experience in the management of patients undergoing systemic therapy with, or without, concurrent radiation therapy 4.7 Explain, where relevant, how treatment decisions have been modified in relation to the pregnant patient 3.3 List common complications of cancer surgery in the curative and palliative settings 5Outcomes, continuing care and palliative care 3.4 Evaluate appropriate surgical options and understand the impact on individual patients 3.5 Describe the rationale of sequencing of surgery in relation to other treatment modalities The trainee is able to: 5.1 Quantify the expected benefits (e.g. overall survival, local control, prolongation of life, symptom control) and detriments (e.g. reduced QoL) arising from the initial management plan 3.6 Evaluate the impact of surgical procedures on radiation planning and delivery for individual patients 3.7 Explain, where relevant, how treatment decisions have been modified in relation to the pregnant patient 4Where systemic therapy (chemotherapy, hormonal therapy, biological agents) may be part of the management plan The trainee is able to: 4.1 D escribe the principles of systemic therapy use and toxicity (acute and late effects) in the curative and palliative setting 4.2 D escribe common disease-specific systemic therapeutic regimens used in the neoadjuvant, concurrent, adjuvant and palliative setting 4.3 D escribe the rationale of sequencing of systemic therapy in relation to other treatment modalities 4.4 D iscuss with the patient the role and implications of concurrent systemic therapy and radiation therapy in a management plan 4.5 E valuate the interaction between systemic therapy and radiation in radiation therapy planning and delivery for individual patients © 2012 RANZCR. Radiation Oncology Training Program Curriculum 5.2 Devise and justify a suitable follow-up program after radiation therapy has been completed 5.3 Re-evaluate the patient’s condition and disease status on an ongoing basis 5.4 Initiate further anti-cancer treatment as required 5.5 Quantify the anticipated outcome from further treatment, including probabilities of salvage (i.e. cure) or symptom relief 5.6 Anticipate potential late radiation-related morbidities; diagnose and manage those that occur 5.7 Select and monitor patients at higher risk for subsequent malignancies 5.8 Select patients and relatives for assessment at familial cancer clinics 5.9 Address issues of psychosocial support through and beyond treatment, and identify patients at high risk of major psychological morbidity Page 41 ROCKKS AND MES 3Where surgery may be part of the management plan Table of Medical Expert Supplement Topics Category Major Focus Lesser Focus Breast Lung and Mediastinum Breast Cancer Head and Neck Mucosal Cancers Salivary Gland Tumours Skin Non-melanomatous Skin Cancer Melanoma Kaposi’s Sarcoma Male Reproductive System Prostate Cancer Seminoma of the Testis Non-Seminomatous Germ Cell Tumours of the Testis Penile Cancer Female Reproductive System Cervical Cancer Uterine Cancer Ovarian Cancer Vulval Cancer Vaginal Cancer Gestational Trophoblastic Disease Urinary Tract Bladder Cancer Kidney Cancer Cancer of the Ureter Non-Small Cell Lung Cancer Small Cell Lung Cancer Superior Vena Caval Obstruction Mesothelioma Tumours of the Mediastinum Gastrointestinal Tract Oesophageal Cancer Biliary Tract & Gall Bladder Cancers Hepatocellular Carcinoma Gastrointestinal Stromal Tumours Carcinoid Tumour Colon Cancer Liver Metastases Gastric Carcinoma Pancreatic Cancer Rectal Cancer Anal Cancer Central Nervous System Adult Glioma Meningioma Pituitary Tumours Medulloblastoma Primitive Neuroectodermal Tumour Cerebral Metastases Malignant Spinal Cord Compression Ependymoma Pineal & Germ Cell Tumours Acoustic Neuroma Cerebral Arteriovenous Malformations Haematology Hodgkin Lymphoma Non-Hodgkin Lymphoma Leukaemia Multiple Myeloma Musculoskeletal & Connective Tissue Paediatric Endocrine Metastatic Disease Soft Tissue Sarcoma Bone Metastases Primary Tumours of the Bone Aggressive Fibromatoses Paediatric Cancers Thyroid Cancer Adrenal Tumours Metastatic Carcinoma of Unknown Primary Site Metastases at sites not otherwise specified above Non-Malignant Clinical Oncology Non-Malignant diseases treated with radiation therapy Symptom Control Quality of Life It is recognised that this list of topics is not exhaustive and that the Radiation Oncologist may be rarely called upon to treat other diseases, and in these situations would base their management plan on ROCKSS. Page 42 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement BREAST MAJOR FOCUS Breast Cancer44 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 43 Breast Cancer 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Known genetic mutations and associations, including BRCA1 and BRCA2 1.1.2 H istological typing and grading of breast cancer 1.1.3 M olecular subtypes of breast cancer (breast cancer intrinsic subtypes) 1.1.4 K nown prognostic and predictive factors for local recurrence and distant relapse after treatment of pre-invasive (ductal carcinoma-in-situ) and invasive breast cancers 1.1.5 U se of immunohistochemistry, in-situ hybridisation assays and micro-array predictive testing 1.1.6 The pathological findings of inflammatory breast cancer (T4d) 1.1.7 The impact of margins of resection on the risk of local recurrence 1.2 Anatomy 1.2.1 P otential alterations to lymphatic drainage following surgery 1.2.2 Anatomy of the internal mammary chain, axilla and the interpectoral (“Rotter’s node”) 1.2.3 Union Internationale Contre le Cancer (International Union Against Cancer UICC) staging including an understanding of the definition and implication of micrometastases and isolated tumour cells (ITC) 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 E valuate routine diagnostic tests e.g. mammogram and ultrasound 2.3.2 S elect patients for further staging investigations e.g. breast MRI, CT scan, Page 44 bone scan, and PET 2.3.3 Understand the limitations that pregnancy imposes on maternal staging investigations 2.3.4 Ascertain when a foetus can be safely delivered 3Management The trainee is able to: 3.1 General [D] 3.1.1 Discuss the impact of pregnancy (on both mother and foetus) on the management process including delaying or embarking on therapy based on foetal age, tumour stage and other prognostic features 3.1.2 Explain the special psychosocial issues relating to the pregnant patient, including the assessment of moral, religious and ethical beliefs regarding termination 3.1.3 Advise patients regarding fertility management and family planning in relation to their cancer 3.1.4 Discuss the implications of genetic mutations e.g. BRCA1, BRCA2 and p53 mutations on local therapy 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the indications for radiation therapy following breast conservation surgery or mastectomy 3.2.2 Discuss the management of regional nodes 3.2.3 Discuss the role of a breast boost 3.2.4 Discuss the role and modalities of partial breast radiation 3.2.5 Discuss altered dose fractionation regimens including their biological basis 3.2.6 Discuss integration of radiation with systemic therapy. 3.2.7 Discuss the use and limitations of predictive models of loco-regional recurrence risk after mastectomy or breast conservation including the integration of biomarkers. (G) 3.3 Surgery [G] 3.3.1 Describe the indications for breast conservation, re-excision and mastectomy for early and locally advanced breast cancer © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3.3.2 D iscuss the role of sentinel lymph node biopsy and axillary dissection 3.3.3 D escribe the types of mastectomy and reconstructive procedures including sequencing with radiation and systemic therapy 3.4 Systemic Therapy [G] 3.4.1 D iscuss the use and sequencing of chemotherapy in early and advanced breast cancer 3.4.2 U nderstand the various “generations” of chemotherapy including their risks and benefits 3.4.3 D iscuss the use and sequencing of hormonal therapy in early and advanced breast cancer 3.4.4 D iscuss the different types of hormonal therapy, including ovarian ablation, and their relative advantages and disadvantages 3.4.5 D iscuss the use of targeted biological therapies, including trastuzamab and lapatinib, and sequencing with radiation therapy 3.4.6 D iscuss the use and limitations of molecular profiling tools 3.4.7 D iscuss the use and limitations of predictive models for systemic therapy the breast, heart, lungs and contralateral breast. 4.2.2 The effect of radiation therapy on the cosmetically augmented breast 4.2.3 The effect of radiation therapy on postmastectomy breast reconstruction 4.2.4 The impact on and risks to a foetus from surgery, radiation therapy and systemic therapy in the situation of the pregnant patient, and according to gestational age 4.2.5 Factors that modify lymphodema risk 5 Screening and Prevention [G] The trainee is able to: 5.1 Discuss the role of chemoprevention 5.2 Describe the role of prophylactic surgery including prophylactic mastectomy and prophylactic oophorectomy 5.3 Select appropriate patients for referral to specialist genetic clinics 5.4 Discuss the role of breast cancer screening 3.5 Other Therapies [G] 3.5.1Discuss the use of bisphosphonates and RANK Ligand inhibitors in the setting of breast cancer 4 Outcomes [D] The trainee is able to discuss: 4.1 Tumour 4.1.1 The risk of relapse and typical time-course (including range) for relapse dependent on risk factors for failure 4.1.2 An appropriate follow-up schedule, including imaging and the role of the specialist versus a general practicioner in the process 4.2 Toxicity 4.2.1 The toxicity of radiation therapy on cutaneous and subcutaneous tissues of © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 45 ROCKKS AND MES Page 46 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement LUNG AND MEDIASTINUM MAJOR FOCUS Non-Small Cell Lung Cancer48 Small Cell Lung Cancer49 Superior Vena Caval Obstruction 50 LESSER FOCUS Mesothelioma50 Tumours of the Mediastinum51 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 47 Non-Small Cell Lung Cancer (NSCLC) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Changing incidence of lung cancer 1.1.2 WHO histological classification of malignant epithelial lung tumours 1.1.3 The 2011 IASLC/ATS/ERS revision of the WHO classification system for adenocarcinomas 1.1.4 R elevance of epidermal growth factor (EGF) receptor over expression 1.2 Anatomy 1.2.1 Nodal stations of the mediastinum 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 D escribe the factors which influence treatment choice (eg weight loss and respiratory function) 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 S elect suitable tests and staging investigations 2.3.1.1 Conventional radiology and PET scanning 2.3.1.2 Invasive procedures e.g. bronchoscopy, endobronchial ultrasound, mediastinoscopy, and video-assisted thoracoscopic surgery (VATS) 2.3.1.3 R espiratory function test and their impact on treatment choice 3Management The trainee is able to: 3.1 General [G] 3.1.1 D iscuss the role of allied health in optimising treatment outcomes (eg dietitician assessment) Page 48 3.2 Radiation Therapy [D and I] 3.2.1 Select patients for curative intent or palliative intent radiation therapy 3.2.2 Describe the rationale and indications for postoperative or preoperative radiation therapy 3.2.3 Evaluate the use of elective nodal irradiation 3.2.4 Evaluate the role of different dose and fractionation schedules (e.g. CHART) for potentially curative or palliative radiation therapy 3.2.5 Describe the technique of thoracic radiation therapy, including a discussion of target volume definitions 3.2.6 Describe techniques which can optimise tumour volume delineation 3.2.7 Describe methods for evaluating and accounting for tumour motion. 3.2.8 Select patients for endobronchial brachytherapy 3.3 Surgery [G] 3.3.1 Discuss the indications for and evaluate surgical options including wedge resection, lobectomy and pneumonectomy 3.3.2 Describe the indications for systematic mediastinal node dissection 3.3.3 Describe the indications for bronchoscopic laser resection and stents 3.4 Systemic Therapy [G] 3.4.1 Discuss the use of adjuvant chemotherapy, following definitive local treatment 3.4.2 Discuss the use of neo-adjuvant chemotherapy 3.4.3 Select patients for concurrent chemo-radiation 3.4.4 Discuss the commonly employed chemotherapy regimens used in neoadjuvant, concurrent and adjuvant settings. 3.5 Other Therapies [G] 3.5.1 Describe the clinical use of molecularly targeted therapies. © 2012 RANZCR. Radiation Oncology Training Program Curriculum 4 Outcome [D] 4.2 Toxicity 4.2.1 Describe the acute and late toxicities of radiation therapy and how to manage them 4.2.2 Explain how and why toxicities are affected by different radiation fractionation protocols e.g. patients on CHART 4.2.3 D escribe the additional toxicity when using concurrent systemic therapy 5 Screening and Prevention [G] The trainee is able to: 5.1 D escribe the impact of community-based programs (especially smoking cessation) and clinical trials to reduce the incidence of lung cancer 5.2 Evaluate the evidence for lung cancer screening Small Cell Lung Cancer (SCLC) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Veterans Affairs Lung Study Group (VALSG) staging system and its advantages and disadvantages compared with the TNM staging system 1.1.2 Relationship of SCLC to other neuroendocrine tumours 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Describe the presenting symptoms and © 2012 RANZCR. Radiation Oncology Training Program Curriculum 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Select suitable investigations to diagnose and stage the disease 2.3.2 Assess relevant prognostic factors for survival and suitability for radical or combined modality treatment 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the use and timing of thoracic radiation therapy in limited and extensive presentations of SCLC 3.2.2 Evaluate the relative benefits of different dose and fractionation schedules for the treatment of thoracic disease 3.2.3 Describe the technique of thoracic radiation therapy, including a discussion of the clinical target volume 3.2.4 Discuss the role of prophylactic cranial irradiation in limited and extensive presentations of SCLC 3.2.5 Describe the technique of prophylactic cranial irradiation, including a discussion of dose 3.2.6 Discuss palliative radiation therapy in SCLC 3.3 Surgery [G] 3.3.1 Discuss the limited use of surgery in SCLC 3.4 Systemic Therapy [G] 3.4.1 Discuss the integration of concomitant chemotherapy and radiation therapy and the compatibility of the common regimens with radiation. 3.5 Other Therapies [G] 4 Outcomes [D] The trainee is able to: 4.1 Tumour Page 49 ROCKKS AND MES The trainee is able to: 4.1 Tumour 4.1.1 Describe the likelihood of different symptoms (e.g. cough, haemoptysis) responding to palliative radiation therapy to the primary tumour signs of SCLC, and contrast these with NSCLC 4.1.1 C ontrast radical (survival) and palliative approaches (symptom control, quality of life, and brain metastasis-free survival) 2.3.1 Select and evaluate the timing and method of biopsy 3Management 4.2 Toxicity 4.2.1 D iscuss the acute and late complications of thoracic radiation therapy and how to manage them 4.2.2 D iscuss the sequelae of prophylactic cranial irradiation 5 Screening and Prevention [G] The trainee is able to discuss the: 5.1 B enefits of smoking cessation as a preventive measure and to increase therapeutic response in established disease Superior Vena Caval Obstruction (SVCO) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 C ommon and uncommon histologies associated with presentation of SVCO; including lung cancers, lymphoma, thymoma and germ cell tumours 1.1.2 D ifferences in presentation of primary disease versus metastatic spread 1.2 Anatomy 1.2.1 Relationship of surrounding structures 1.2.2 B ony landmarks relevant to the mediastinal region 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 E licit symptoms of SVCO 2.1.2 E licit symptoms of underlying malignancy 2.2 Physical Examination 2.2.1 D iscuss signs of SVCO and to distinguish rapid versus slower development of SVCO 2.3 Investigation and Evaluation [S] Page 50 The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy[D and I] 3.2.1 Discuss options for patient positioning e.g. the treatment of severely dyspnoeic patients 3.2.2 Describe methods of delineation of the target volume where CT is not possible 3.3 Surgery [G] 3.3.1 Evaluate the indications for stenting 3.3.2 Explain the role of open biopsy 3.4 Systemic Therapy [G] 3.4.1 Discuss the indications for initial chemotherapy as an alternative to initial radiation therapy 3.4.2 Describe the role of chemotherapy in conjunction with radiation therapy in the curative and palliative settings, including consideration of sequencing and timing 3.5 Other Therapies [D] 3.5.1 Discuss the use of oxygen, corticosteroids and analgesia as supportive measures 4 Outcomes [D] 4.1 Tumour 4.2 Toxicity Mesothelioma 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The importance of asbestos in aetiology 1.1.2 Subtypes, classification and immunohistochemistry 1.2 Anatomy 1.2.1 Extent of pleural lining in hemithorax © 2012 RANZCR. Radiation Oncology Training Program Curriculum Tumours of the Mediastinum 2.1 History 2.2 Physical Examination Note: topics that overlap with this category are covered in other sections e.g. lymphoma, germ cell tumour, and carcinoid 2.3 Investigation and Evaluation 1 Oncology Sciences [D] 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the place of radiation therapy in the definitive management of mesothelioma 3.2.2 Discuss the place of radiation therapy in the adjuvant setting, following extrapleural pneumonectomy 3.2.3 Discuss the use of radiation therapy in preventing or treating needle tract recurrence after thoracoscopy/thoracotomy 3.2.4 Discuss the use of radiation therapy in the palliative setting 3.3 Surgery [G] 3.3.1 Describe the indications for, and surgical techniques of: 3.3.1.1 Pleurodesis 3.3.1.2 Pleurectomy 3.3.1.3 Extrapleural pneumonectomy 3 Outcomes [D] The trainee is able to discuss the: 3.1 Tumour 3.1.1 Changing patterns of disease relapse with improved local treatment The trainee is able to describe the: 1.1 Pathology 1.1.1 Common histologies in relation to anatomical location 1.1.2 Spectrum of thymus tumours: thymoma through to thymic carcinoma (WHO classification) 1.1.3 Masaoka staging system for thymic epithelial tumours 1.2 Anatomy 1.2.1 Division of the mediastinum and the structures within 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Recognise the association between paraneoplastic disorders (eg myasthenia gravis) and thymoma 2.2 Physical Examination 2.2.1 Describe the symptoms and signs occurring as a result of compression of mediastinal structures. 2.3 Investigation and Evaluation 2.3.1 Select suitable diagnostic tests: chest x-ray, CT, mediastinoscopy, and MIBG 2.3.2 Assess suitability for treatment, including assessing lung function 3.2 Toxicity 4 Screening and Prevention [G] The trainee is able to discuss the: 4.1 Utility of surveillance imaging in the at-risk group 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the indications for radiation therapy © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 51 ROCKKS AND MES 2 Clinical assessment [D and I] 3.3 Surgery [G] 3.3.1 D iscuss the role of surgery, especially thymic tumours 3.3.2 D escribe the importance of the extent of resection 3.4 Systemic Therapy [G] 3.4.1 D iscuss the role of chemotherapy in the neoadjuvant, concurrent or adjuvant setting. 3.4.2 D iscuss the role of chemotherapy for metastatic disease 3.5 Other Therapies [G] 3.5.1 D iscuss the role of octreotide in the management of thymic tumours 4 Outcomes [D] The trainee is able to discuss the: 4.1 Tumour 4.1.1 Impact of local therapy on the symptoms of paraneoplastic syndrome 4.1.2 The need for prolonged follow-up, to detect late relapses. 4.2 Toxicity 4.2.1 Morbidity of surgery Page 52 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement HEAD AND NECK MAJOR FOCUS Mucosal Cancers54 Salivary Gland Tumours54 Specific Head and Neck Cancer Sites 55 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 53 Mucosal Cancers and Salivary Gland Tumours The important common features of these tumours are outlined below. Following the general headings are specific features relating to individual sites. 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 M acroscopic features of a tumour (i.e. exophytic versus endophytic) and the implications for choice of treatment modality 1.1.2 C ausal factors/pathogenesis especially the role of HPV 16 and its impact on prognosis 1.1.3 Implications of EGFR over-expression in mucosal squamous cell carcinoma (SCC) 1.1.4 Importance of field change, precursors, risk factors and the incidence of multiple primaries 1.2 Anatomy 1.2.1 P athway of each of the cranial nerves, and demonstrate an understanding of how this anatomy impacts on the various treatment techniques used to treat head and neck cancer 1.2.2 D efine the location of the brachial plexus on CT and MRI 1.2.3 L ymph node stations and levels including an awareness of the typical subsites which drain to each lymph node level and laterality of drainage. 2 Clinical Assessment [D and I] The trainee is able to: 2.1 General 2.1.1 D escribe the relevance of synchronous primaries occurring in the aerodigestive tract 2.2 History 2.2.1 E licit the history of referred pain e.g. otalgia 2.3 Physical examination 2.3.1 Perform nasoendoscopy and indirect laryngoscopy Page 54 2.3.2 Elicit signs of cranial nerve palsies 2.3.3 Assess a patient for impending airway obstruction 2.3.4 Elicit signs of trismus and understand its significance 2.4 Investigation and evaluation 2.4.1 Discuss the limitations of CT imaging for staging head and neck malignancies and the role of MRI and PET imaging 2.4.2 Synthesise panendoscopy, biopsy and operative reports including assessment of factors (e.g. number and size of involved nodes, presence of extracapsular extension) that impact on radiation therapy recommendation 2.4.3 Describe the importance of pre-treatment dental assessment and select patients for dental referral 3Management The trainee is able to: 3.1 General [G] 3.1.1 Understand the importance of pre-treatment multidisciplinary team assessment, including dietician and speech therapist 3.1.2 Understand the diagnostic workup of metastatic SCC of unknown primary origin involving the neck (eg the role of PET, EUA and biopsy). Understand the different management paths for each of the possible mucosal primary sites and the rationale for comprehensive RT (ie all potential primary sites and bilateral neck nodes) in unknown primary of presumed mucosal origin. 3.2 Radiation Therapy [D and I] 3.2.1 Select patients for definitive radiation therapy 3.2.2 Select patients for post-operative radiation therapy 3.2.3 Discuss the indications for elective nodal irradiation 3.2.4 Discuss the rationale and selection of patients for altered fractionation schedules 3.2.5 List the indications for including the tracheal stoma within the treatment field 3.2.6 Evaluate parotid-sparing techniques © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3.2.7 S elect patients suitable for brachytherapy 3.2.8 D iscuss the role and risks of re-irradiation (including brachytherapy) for local recurrence 3.3 Surgery [G] 3.3.1 D iscuss the types of neck dissection and the implications for post-operative radiation therapy techniques 3.3.2 D iscuss the use of a planned neck dissection after radiation therapy 3.3.3 Discuss the role of salvage surgery 3.3.4 D escribe the impact of definitive surgical procedures on anatomical function, quality of life and cosmesis 3.4 Systemic Therapy [G] 3.4.1 D iscuss the evidence for combined chemoradiation in the definitive and adjuvant settings 3.4.2 D efine the risks associated with combined chemo-radiation and discuss ways to support a patient through chemo-radiation to avoid breaks in treatment 3.5 Other Therapies [G] 3.5.1 D iscuss the role of biological modifiers e.g. EGFR inhibitors and anti-hypoxic agents 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 Discuss the radiobiological concepts underlying the effect of extending overall treatment time on tumour control 4.1.2 Discuss the impact on tumour control (and toxicity) of continued smoking during treatment 4.2 Toxicity 4.2.1 Describe the potential acute and late RT-related toxicities and the management of these. 4.2.2 Manage mucositis with allied health team 4.2.3 S elect patients for Percutaneous Endoscopic Gastrostomy (PEG) insertion 4.2.4 Describe the management of xerostomia 4.2.5 L ist the risk factors for development and management of osteoradionecrosis of the jaw © 2012 RANZCR. Radiation Oncology Training Program Curriculum 5 Screening and Prevention [G] The trainee is able to discuss: 5.1 Anti-smoking advice aimed at individuals and the community ROCKKS AND MES Specific Head and Neck cancer sites: [D] A Nasal Cavity and Paranasal Sinuses The trainee is able to: A.1 Pathology A.1.1 Describe the prognostic significance and natural history of less common histologies such as sinonasal undifferentiated tumours, adenoid cystic carcinomas, inverted papilllomas and esthesioneuroblastoma A.1.2 Assess and understand the prognostic significance of intracranial extension A.2 Anatomy A.2.1 Identify and describe the paranasal subsites. A.3 Management A.3.1 List the indications for orbital exenteration A.3.2 Describe dental prostheses e.g. obturator A.3.3 Describe ocular-sparing radiation techniques A.4 Outcomes A.4.1 Minimise and manage acute and late ocular toxicities BNasopharynx B.1 Pathology B.1.1 L ist the endemic areas and discuss the associated dietary and viral aetiological factors B.1.2 Describe the WHO classification system B.1.3 D escribe the natural history with regard to nodal and distant metastases B.1.4 D escribe features and the natural history of angiofibromas B.2 Anatomy B.2.1 D escribe the boundaries of the nasopharynx Page 55 B.3 Management B.3.1 D iscuss the role of brachytherapy in boosting the primary tumour and in the setting of recurrence D.3.3 D iscuss the functional impact and quality of life implications for partial and total glossectomy EHypopharynx B.4 Outcomes B.4.1 Assess the risk of and manage late effects to the temporal lobe and hearing apparatus E.1 Anatomy E.1.1 List the subsites of the hypopharynx and describe the anatomical boundaries of the pyriform fossa CLarynx C.1 Anatomy C.1.1 D escribe the subsites of the larynx and the components of each C.2 Physical examination C.2.1 Assess for supra- and sub-glottic extension and thyroid cartilage involvement subite. C.3 Management C.3.1 Compare and contrast treatment outcomes of radiation, surgery and endoscopic laser resection; in particular for functional outcome and cure C.3.2 Describe the potential complications of supraglottic laryngectomy with or without adjuvant radiation E.2 Physical Examination and Investigations E.2.1 Assess the patient for involvement of the posterior pharyngeal wall and for retropharyngeal node involvement E.3 Management E.3.1 Radiation Therapy E.3.1.1 Discuss the importance of neck and shoulder positioning E.3.1.2 Discuss the indications and the treatment techniques available for including the superior mediastinum E.3.2 Surgery E.3.2.1 List the indications for pharyngolaryngectomy and the surgical options for reconstruction F Salivary Gland Tumours D Oral Cavity and Oropharynx D.1 Anatomy D.1.1 L ist the subsites of the oral cavity and oropharynx D.1.2 D escribe the vascular supply of the tongue and the implications for surgical management D.2 Physical Examination and Investigations D.2.1 Assess the patient for involvement of the pharyngeal wall and for retropharyngeal node involvement D.3 Management D.3.1 D iscuss the treatment implications of involvement of the mandible D.3.2 C ompare and contrast the functional and cosmetic results of surgery versus the morbidity of radiation therapy for early oral cavity tumours Page 56 F.1 Pathology F.1.1 D escribe the prognostic significance and natural history of less common histologies such as pleomorphic adenomas, Warthins tumours, mucoepidermoid carcinomas, acinic cell carcinomas and adenoid cystic carcinomas F.2 Management F.2.1 D iscuss the implications of perineural invasion or adenoid cystic pathology on radiation treatment fields F.2.2 D iscuss the positioning techniques and beam arrangements needed to minimise dose to the contralateral eye in parotid treatment F.2.3 C ontrast the management of primary and secondary tumours in the parotid © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement SKIN MAJOR FOCUS Non Melanomatous Skin Cancer 58 Melanoma59 LESSER FOCUS Kaposi’s Sarcoma59 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 57 Non Melanomatous Skin Cancer (including Merkel Cell Carcinoma) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Importance of Gorlin’s syndrome, albinism and racial susceptibility 1.1.2 R ole of UV exposure and topical carcinogens 1.1.3 E ffect of immunosuppression e.g. transplant patients 1.2 Anatomy 1.2.1 C ranial nerve pathways that might be affected by perineural spread 1.2.2 Lymph node drainage 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 R ecognise the patient factors (age, comorbidities) and tumour factors (stage, site) which may impact on treatment decision making 2.2 Physical Examination 2.2.1 R ecognise the clinical appearance of BCC, SCC, IEC and Merkel cell carcinoma 2.2.2 Accurately assess tumour extent 2.3 Investigation and Evaluation 2.3.1 S elect suitable means of obtaining histological diagnosis e.g. excision versus incisional biopsy/shave biopsy 2.3.2 D iscuss indications and rationale for imaging the primary tumour or draining lymph nodes 3Management The trainee is able to: 3.1 General 3.1.1 D emonstrate a sound understanding of surgical and non surgical treatments for skin cancer [G] Page 58 3.2 Radiation Therapy [D and I] 3.2.1 Evaluate the relative merits of definitive treatment with radiation therapy versus surgery 3.2.2 Select and explain the use of various treatment modalities and techniques e.g. electrons, superficial/orthovoltage photons, and megavoltage photons 3.2.3 Identify indications for post-operative radiation therapy to primary site 3.2.4 Identify indications for radiation therapy to draining nodal regions 3.3 Surgery [G] 3.3.1 Discuss the indication for, and possible complications of, the various skin surgical techniques including split skin grafts, flap repair, lymph node dissection and Moh’s technique 3.4 Systemic Therapy [G] 3.4.1 Discuss the uses of chemotherapy in the management of Merkel cell carcinoma 3.5 Other Therapies [G] 3.5.1 Explain the role of immunotherapy, Photo dynamic Therapy, laser and cryotherapy 3.5.2 Discuss the role of topical agents 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 Recognise the variable response rates of different tumour types to ionizing radiation 4.2 Toxicity 4.2.1 Recognise factors that influence the development of late effects, including the expected cosmetic outcome 5 Screening and Prevention [G] The trainee is able to: 5.1 Explain principles of prevention 5.1.1 Identifying people with genetic predisposition 5.1.2 Individual and community education on UV protection © 2012 RANZCR. Radiation Oncology Training Program Curriculum 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Growth patterns and histological subtypes 1.1.2 Natural history of non-cutaneous sites of melanoma e.g. ocular, mucosal 1.2 Anatomy 1.2.1 Lymphatic drainage of regions of the skin 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Discuss relative benefits of PET, MRI and CT in staging assessment 3.4 Systemic Therapy [G] 3.4.1 Describe the indications for, and possible benefits of, regional chemotherapy 3.4.2 Discuss the indications for, and possible benefits of, immunotherapy (e.g. interferon) and molecularly targeted biological therapies 3.5 Other therapy [G] 4 Outcomes [D] 4.1 Tumour 4.2 Toxicity 5 Screening and Prevention [G] The trainee is able to: 5.1 Advise individuals and the community regarding effective skin protection from UV radiation Kaposi’s Sarcoma 3Management 1 Oncology Sciences [D] The trainee is able to: 3.1 General [G] The trainee is able to describe the: 1.1 Pathology 1.1.1 Four epidemiological subtypes 1.1.2 Differentiation from angiosarcoma 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the use of post-operative radiation therapy to the primary site and nodal regions 3.2.2 Discuss the use of radiation therapy in the management of locally advanced, recurrent, in-transit, and metastatic disease 3.3 Surgery [G] 3.3.1 Describe the importance of excision margins 3.3.2 Describe the role of surgery in the management of nodal disease, including the place of sentinel node biopsy 3.3.3 Describe the role of surgery in the management of locally recurrent, in-transit and metastatic disease © 2012 RANZCR. Radiation Oncology Training Program Curriculum 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Elicit a history of risk factors for Kaposi’s sarcoma 2.2 Physical Examination Recognise the clinical appearance of KS and the typical anatomical sites of origin 2.3 Investigation and Evaluation Page 59 ROCKKS AND MES Melanoma 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 D iscuss radiosensitivity, suitable range of radiation doses, fractionation schedules and techniques for treatment e.g. superficial x-ray therapy (SXRT) and electrons for solitary superficial lesions; megavoltage photons for lesions covering the majority of a limb 3.2.2 Discuss the effectiveness of re-treatment 3.3 Surgery [G] 3.3.1 D escribe the limited role of surgery in biopsy confirmation 3.4 Systemic Therapy [G] 3.4.1 D iscuss the systemic treatment of lesions refractory to radiation therapy 3.5 Other Therapies [G] 3.5.1 D escribe other potentially effective treatments including interferon α-2a given subcutaneously or intra-lesionally, antiviral treatments in HIV/AIDS patients, and liposomal anthracyclines 4 Outcomes [D] 4.1 Tumour 4.1.1 R ecognise the appearance of KS post treatment (pigmentation commonly retained) 4.2 Toxicity 4.2.1 B e aware of increased mucosal toxicity from radiotherapy in HIV related KS. Page 60 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement MALE REPRODUCTIVE SYSTEM MAJOR FOCUS Prostate Cancer62 Seminoma Of The Testis63 LESSER FOCUS Non-Seminomatous Germ Cell Tumours of Testis 64 Penile Cancer65 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 61 Prostate Cancer 3Management 1 Oncology Sciences [D] The trainee is able to: 3.1 General 3.1.1 Discuss the approach of active surveillance, including the rationale, patient selection, a suitable follow-up program and the factors influencing a decision to proceed with definitive treatment [G] 3.1.2 Discuss appropriate treatment options for low-, intermediate- and high risk prostate cancer [D] 3.1.3 Define biochemical relapse following surgery and radiotherapy/brachytherapy [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 P SA: general structure, function and use (including free to total ratio) 1.1.2 G leason grading and scoring and the TNM staging system 1.1.3 R are non-adenocarcinoma subtypes e.g. sarcoma, neuroendocrine tumours 1.1.4 R elevance of defining so-called “insignificant” prostate cancers 1.2 Anatomy 1.2.1 L ocation and relations of the apex and the neurovascular bundle 1.2.2 N on sequential lymphatic drainage of the prostate 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Assess urinary function, including obstructive symptoms and continence including the use of standard scoring systems e.g. IPSS 2.1.2 Assess erectile function including the use of standardised scoring systems e.g. IEFS 2.2 Physical Examination 2.2.1 C linically stage prostate cancer using digital rectal examination 2.3 Investigation and Evaluation 2.3.1 S elect and evaluate relevant diagnostic tests including CT scan, bone scan and MRI 2.3.2 D escribe prognostic factors e.g. stage, Gleason score, PSA at presentation, PSA doubling time, volume of disease and number of positive biopsies, presence of perineural invasion 2.3.3 S tratify patients into low, intermediate or high risk Page 62 3.2 Radiation Therapy [D and I] 3.2.1 Discuss physiological and positional variation in target position 3.2.2 Discuss the issues associated with elective pelvic nodal radiation, dose escalation, IMRT and IGRT including fiducial markers and cone beam CT 3.2.3 Discuss issues regarding adjuvant/salvage post prostatectomy EBRT including indications and timing of treatment 3.2.4 Discuss the selection criteria, technique and procedure for HDR and LDR brachytherapy 3.2.5 Describe the use of external beam radiotherapy and radiopharmaceuticals (e.g. strontium-89,samarium) for palliation 3.3 Surgery [D] 3.3.1 Discuss the indications and toxicity associated with prostatic biopsy, TURP, prostatectomy and salvage surgery after brachytherapy or external beam radiotherapy 3.3.2 Describe surgical techniques used in the palliative setting e.g. trans-urethral resection of the prostate (TURP) and ureteric stenting 3.4 Systemic Therapy [G] 3.4.1 Discuss systemic treatment options for castrate resistant prostate cancer including an awareness of mechanism of action and optimal sequencing © 2012 RANZCR. Radiation Oncology Training Program Curriculum 4 Outcomes [D] Collaborative Group (IGCCCG) and Marsden systems 1.1.3 Tumour markers associated with seminoma and their significance 1.1.4 The relevance of maldescended testes 1.1.5 Pathological prognostic factors 1.2 Anatomy 1.2.1 The drainage of testicular lymphatics to retroperitoneum, and circumstances in which this is disrupted 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Elicit a history including prior pelvic surgery, testosterone deficiency, fertility status and the intention for future children 4.1 Tumour 4.1.1 Discuss the expected outcomes for external beam radiotherapy and brachytherapy for low-, intermediate- and high risk prostate cancer 2.2 Physical Examination 2.3 Investigation and Evaluation 4.2 Toxicity 4.2.1 Discuss incidence and management of late rectal, urethral and bladder toxicity. 4.2.2 Discuss the management of erectile dysfunction The trainee is able to: 3.1 General [G] 5 Screening and Prevention [D] The trainee is able to: 5.1 D iscuss the role of serum PSA measurement and digital rectal examination as screening tools for the early identification of patients with prostate Seminoma of the Testis 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 Pathological classification of testicular tumours 1.1.2 The rationale for non-TNM staging systems e.g. International Germ Cell Cancer © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3Management 3.2 Radiation Therapy [D and I] 3.2.1 Select patients suitable for adjuvant or definitive radiation treatment to lymph node groups (stages I and II) and palliative treatment 3.2.2 Describe rationale for selecting para-aortic or para-aortic plus pelvic (dog-leg) nodal irradiation as well as an appropriate dosefractionation schedule 3.2.3 Discuss the potential and historical indications for hemi-scrotal irradiation 3.2.4 Discuss the indications for radiation therapy in the situation of postchemotherapy residual nodal disease 3.3 Surgery [G] 3.3.1 Discuss the approach and procedure of radical inguinal orchidectomy 3.3.2 Discuss the risk of scrotal and nodal recurrence resulting from trans-scrotal incision and/or exploration Page 63 ROCKKS AND MES 3.5 Other Therapies 3.5.1 D escribe the rationale, mechanism of action and indications for the use of androgen deprivation therapy in the neoadjuvant, adjuvant and palliative setting including a discussion of timing and duration of therapy [D] 3.5.2 D escribe the potential morbidity of androgen deprivation therapy and appropriate management strategies [D} 3.5.3 D escribe the rationale, mechanism of action of and timing of bisphosphonates and denosumab in the setting of bone metastases [D] 3.5.4 D escribe, in simple terms, the role of other local treatments such as cryotherapy and high frequency US (HiFU) [G] 3.3.3 D iscuss the limited role of retroperitoneal node dissection 3.4 Systemic Therapy [G] 3.4.1 E valuate the evidence for adjuvant chemotherapy for stage I disease 3.4.2 E valuate the place of chemotherapy versus radiation therapy for stage II disease 3.5 Other Therapies [I] 3.5.1 S elect patients suitable for a surveillance program and discuss the relative merits and disadvantages of this approach 3.5.2 D escribe a suitable follow-up program for patients opting for surveillance 4 Outcomes [D] The trainee is able to discuss: 4.1 Tumour 4.1.1 The 5-year relapse free rates for men with stage one seminoma managed with surveillance, radiotherapy and single agent chemotherapy 4.1.2 The long term risk of a contralateral testicular tumour 4.2 Toxicity 4.2.1 The risk, management and prevention of infertility 4.2.2 The risk, management and prevention of testosterone deficiency 4.2.3 The evidence for and against iatrogenic carcinogenesis and cardiovascular morbidity in relationship to testis cancer therapy 4.2.4 The comparative toxicities of prophylactic radiation therapy versus chemotherapy stage I disease 5 Screening and Prevention [G] The trainee is able to explain: 5.1 The rationale as to why population screening is not generally advocated Page 64 Non-Seminomatous Germ Cell Tumours of Testis (NSGCT) 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 Pathological classification of testicular tumours 1.1.2 Staging systems e.g. Royal Marsden Hospital 1.1.3 The differences between NSGCTs and seminomas in terms of histology, natural history, mode of spread and biological behaviour 1.1.4 In the case of mixed tumours, which histology should be used to determine therapy 1.1.5 Serum tumour markers associated with NSGCT 1.2 Anatomy 1.2.1 The drainage of lymphatics to retroperitoneum, and circumstances in which this is disrupted 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Elicit clinical features (e.g. prior pelvic surgery, scrotal involvement) impacting on patterns of potential nodal spread 2.1.2 Describe the endocrine manifestations of testicular tumours 2.2 Physical Examination 2.2.1 Describe the clinical presentation of extra-gonadal germ cell tumours including retroperitoneal, mediastinal and cerebral manifestations 2.3 Investigation and Evaluation 2.3.1 Select and interpret investigations including tumour markers, CT scans and PET scanning 2.3.2 Demonstrate an understanding of the International Germ Cell Cancer Collaborative Group (IGCCCG) staging system and the impact on treatment options © 2012 RANZCR. Radiation Oncology Training Program Curriculum 4 Outcomes [D] The trainee is able to describe: 3.1 General [G] 3.1.1 The impact of therapy (including active surveillance) on follow-up imaging choices and schedules 3.1.2 A suitable “surveillance” program for men under observation for low-risk, stage I disease, and what constitutes a low-risk group 3.1.3 The significance and natural history of a diagnosis of teratoma at presentation and in a residual mass post-chemotherapy 3.1.4 The management of reduced fertility 3.1.5 The clinical use of serum tumour markers The trainee is able to: 4.1 Tumour 4.1.1 Recognise situations at presentation and relapse which are still amenable to potentially curative therapy despite widespread metastatic disease The trainee is able to discuss: 3.2 Radiation Therapy [D and I] 3.2.1 Indications for retroperitoneal nodal irradiation; relative benefits versus surveillance versus chemotherapy as initial treatment 3.2.2 The use of radiation therapy following chemotherapy; dissection versus nodal irradiation 3.2.3 The use of radiation therapy to metastatic sites (e.g. brain) in potentially curative and palliative settings The trainee is able to: 3.3 Surgery [G] 3.3.1 Outline the approach for inguinal orchidectomy 3.3.2 Describe the utility of contralateral testicular biopsy 3.3.3 Describe the indications for, and the surgical approach to, retroperitoneal lymph node dissection The trainee is able to: 3.4 Systemic Therapy [G] 3.4.1 D escribe first line chemotherapy options 3.4.2 E xplain the evidence for and against the use of high-dose chemotherapy with stem cell rescue in the initial management © 2012 RANZCR. Radiation Oncology Training Program Curriculum 4.2 Toxicity 4.2.1 Describe the pathophysiology and morbidity of bleomycin-induced pulmonary fibrosis 5 Screening and Prevention [D] The trainee is able to discuss: 5.1 The value of self examination of the testes 5.2 With patients the risk of second testis cancer (seminoma or NSGCT) and to give an opinion on the value of tumour marker testing for early diagnosis Penile Cancer 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The importance of risk factors e.g. phimosis, presence of foreskin and HPV 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.3 Investigations and Evaluation 2.3.1 Assess degree of urethral involvement using information from urethroscopy/ cystoscopy report 2.3.2 Radiologically assess the inguinal regions and pelvis for nodal involvement Page 65 ROCKKS AND MES 3Management 3Management The trainee is able to: 3.1 General [G] 3.1.1 D iscuss the choice of treatment in terms of tumour control and the preservation of sexual and urinary function 3.1.2 D escribe the prognostic significance of nodal involvement 3.2 Radiation Therapy [D and I] 3.2.1 D iscuss the role of prophylactic nodal irradiation following the surgical treatment of the primary lesion 3.2.2 D iscuss the relative benefits of radiation as definitive treatment to the primary tumour 3.2.3 D iscuss indications for brachytherapy for penile preservation 3.3 Surgery [G] 3.3.1 E valuate the place of sentinel node biopsy or superficial nodal dissection for clinically node negative patients 3.4 Systemic Therapy [G] 3.4.1 E valuate the use of chemotherapy in locally advanced disease treated with curative radiation therapy 3.5 Other Therapies [G] 3.5.1 E valuate the potential role for various non-surgical techniques for in-situ disease e.g. topical 5-flurouracil, photodynamic therapy, and laser treatment 4 Outcomes [D] 4.1 Tumour 4.2 Toxicity Page 66 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement FEMALE REPRODUCTIVE SYSTEM MAJOR FOCUS Cervical Cancer68 Uterine Cancer69 LESSER FOCUS Ovarian Cancer69 Vulval Cancer70 Vaginal Cancer71 Gestational Trophoblastic Disease72 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 67 Cervical Cancer 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 P athogenesis, including the role of HPV subtypes 1.1.2 S ignificance of the natural history of cervical intraepithelial neoplasia (CIN) 1-3 1.1.3 K nowledge of rare types of cervical cancer such as small cell/carcinosarcoma 1.1.4 The International Federation of Gynaecologists and Obstetricians (FIGO) staging system 1.2 Anatomy 1.2.1 Borders and contents of the parametrium 1.2.2 P otential alterations to lymphatic drainage following surgery 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.2.1 P erform an EUA to clinically stage cervical cancer [S] 2.3 Investigation and Evaluation 2.3.1 L ist the relative advantages and disadvantages of the FIGO and TNM staging systems for cervical cancer 2.3.2 L ist the prognostic factors that influence local control and survival in cervical cancer e.g. anaemia, nodal positivity 2.3.3 D iscuss the relative benefits of various imaging modalities e.g. CT, MRI, PET 3Management The trainee is able to: 3.1 General [D] 3.1.1 D iscuss pre-treatment measures that may be performed to optimise outcomes from treatment e.g. blood transfusion, ureteric stents Page 68 3.1.2 Discuss the impact on management decisions in the situation of a pregnant patient (see Breast page 44 for detailed learning outcomes) 3.2 Radiation Therapy [D and I] 3.2.1 Discuss timing of external beam radiation and brachytherapy 3.2.2 Discuss selection of brachytherapy devices [S] 3.2.3 Discuss HDR versus LDR versus PDR brachytherapy, including procedure, dose and fractionation 3.2.4 Apply relevant ICRU reporting principles to brachytherapy and discuss potential limitations 3.2.5 Discuss the issues associated with extended field radiation therapy 3.2.6 Discuss the role of IMRT in terms of reduction of late effects to the small bowel 3.2.7 Discuss the use of radiation in the postoperative setting 3.3 Surgery [G] 3.3.1 Evaluate patients for definitive surgery 3.3.2 Explain the different types of surgery, including fertility-preserving surgery 3.3.3 Describe a management plan for cervical cancer in a pregnant woman 3.3.4 Evaluate the role of surgery following post-radiation recurrence 3.4 Systemic Therapy [G] 3.4.1 Discuss the rationale and select patients for concurrent chemoradiation 3.4.2 Discuss the role of adjuvant chemotherapy and its integration with radiation therapy 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.2 Toxicity 4.2.1 Identify and manage the endocrine and sexual morbidities of treatment e.g. vaginal effects, menopause, and altered body image 4.2.2 Identify and manage late small bowel toxicity © 2012 RANZCR. Radiation Oncology Training Program Curriculum The trainee is able to: 5.1 D iscuss cervical cancer screening programs e.g. evidence, rationale, outcomes, and structure 5.2 D escribe the evidence, rationale and structure of the HPV vaccine program Uterine Cancer 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 Type 1 and Type 2 endometrial cancer (based on microscopic appearance, clinical behaviour, and epidemiology) 1.1.2 Grading system used for endometrioid tumours 1.1.3 Pathological features of uterine sarcomas 1.1.4 FIGO and TNM staging 1.2 Anatomy 1.2.1 Potential anatomical route of malignant spread transperitoneally 1.2.2 Borders and contents of parametrium 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Recognise commonly associated comorbidities (hypertension, obesity, diabetes mellitus, and previous pelvic radiation therapy) and their impact on management 2.2 Physical Examination 2.2.1 Perform a pelvic examination in women under anaesthetic or as an outpatient, including obtaining cervical smears 3Management recurrence following pelvic surgery and the indications for post-operative radiation therapy 3.2.2 Detail the indications for definitive radiation therapy including where surgery is inappropriate 3.2.3 Describe the indications for brachytherapy in the management of uterine cancer 3.2.4 Describe the radiobiological and physical aspects of brachytherapy – LDR, HDR, and PDR afterloading equipment 3.2.5 Perform brachytherapy insertions using vaginal ovoids and vaginal applicators 3.3 Surgery [G] 3.3.1 Describe the general techniques for surgical resection (total abdominal hysterectomy and bilateral salpingooophorectomy – TAHBSO) 3.3.2 Describe modifications to surgical procedures – extrafascial/radical hysterectomy 3.3.3 Describe the indications for surgical staging and components of the procedure (exploration, cytology, TAHBSO, omental biopsy and selective lymphadenectomy) 3.4 Systemic Therapy [G] 3.4.1 Discuss the role of chemotherapy (eg as an alternative to adjuvant radiation or given concurrently with radiation therapy) 3.5 Other Therapies [D] 3.5.1 Describe the use of hormones in uterine cancer (provera and tamoxifen) 4 Outcomes [D] 4.1 Tumour 4.2 Toxicity Ovarian Cancer The trainee is able to: 3.1 General [G] 1 Oncology Sciences [D] 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the prognostic factors for The trainee is able to describe the: 1.1 Pathology © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 69 ROCKKS AND MES 5 Screening and Prevention [G] 1.1.1 Importance of BRCA 1 and 2 mutations 1.1.2 N atural history of ovarian carcinoma, borderline tumours, and germ cell tumours 4 Outcomes [D] 4.1 Tumour 1.2 Anatomy 1.2.1 D escribe the route of transperitoneal spread 4.2 Toxicity 2 Clinical Assessment [D and I] The trainee is able to: 5.1 Evaluate the screening options in BRCA 1 and 2 carriers The trainee is able to: 2.1 History 5 Screening and Prevention [G] 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 S elect and interpret suitable tests for diagnosis and staging, including Ca125 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 D iscuss the use of radiation therapy in ovarian cancer 3.2.2 D emonstrate an awareness of the controversies surrounding the use of whole abdominal radiation therapy 3.2.2.1 D escribe the fields that constitute whole abdominal radiation therapy 3.2.2.2 D iscuss doses and normal tissue constraints 3.3 Surgery [G] 3.3.1 D escribe benefits of surgical staging and second-look laparotomy 3.3.2 D escribe advantages and disadvantages of palliative surgical procedures 3.4 Systemic Therapy [G] 3.4.1 D iscuss the use of chemotherapy in ovarian cancer 3.4.2 S elect appropriate patients for adjuvant chemotherapy (for either intravenous and/ or intraperitoneal chemotherapy) 5.2 Discuss the advantages and disadvantages of prophylactic oophorectomy in BRCA 1 and 2 carriers Vulval Cancer 1 Oncology Sciences [D] The trainee is able to: 1.1 Pathology 1.1.1 Discuss the natural history of vulvar intraepithelial neoplasia (VIN) 1.2 Anatomy 1.2.1 Describe the lymphatic drainage of the vulva 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.2.1 Perform a clinical examination (under anaesthetic if required [S]) 2.3 Investigation and Evaluation 2.3.1 List the surgical and non-surgical prognostic factors that influence local control and survival in vulval cancer, e.g. depth of invasion, lymphovascular space invasion, nodal status, excision margins 3Management The trainee is able to: 3.1 General [G] Page 70 © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3.3 Surgery [G] 3.3.1 E xplain the different types of surgery (wide local excision, hemi-vulvectomy, and vulvectomy) 3.3.2 S elect appropriate patients for sentinel node biopsy or inguinal lymph node dissection (unilateral versus bilateral) [D] 3.4 Systemic Therapy [G] 3.4.1 E valuate the use of concurrent chemotherapy during radiation therapy for vulval cancers 4 Outcomes [D] The trainee is able to describe: 4.1 Tumour 4.2 Toxicity 4.2.1 Discuss the conditions that may lead to a break during radiation therapy and their management 4.2.2 The effect treatment has on sexual function (vaginal effects, menopause, and altered body image) and the available management options 4.2.3 Lymphodema risks and management © 2012 RANZCR. Radiation Oncology Training Program Curriculum Vaginal Cancer 1 Oncology Sciences [D] The trainee is able to: 1.1 Pathology 1.1.1 Discuss muliticentricity and clinical importance 1.2 Anatomy 1.2.1 Describe the differences in lymphatic drainage of the upper 2/3 and lower 1/3 of the vagina 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination [S] 2.2.1 Perform an EUA to stage vaginal cancer using the FIGO clinical staging system 2.3 Investigation and Evaluation 2.3.1 Describe the prognostic factors that influence local control and survival in vaginal cancer 2.3.2 Diagnose the presence of a rectovaginal or vesicovaginal fistula 2.3.3 Synthesise information regarding the tumour’s involvement of and proximity to local structures and the psychosocial needs of the patient, to arrive at a management approach 3Management 3.1 General [G] The trainee is able to describe: 3.2 Radiation Therapy [D and I] 3.2.1 The use of intracavitary and interstitial brachytherapy in the definitive and adjuvant treatment setting The trainee is able to describe: 3.3 Surgery [G] 3.3.1 Definitive surgical techniques 3.3.2 The surgical management of fistulae Page 71 ROCKKS AND MES 3.2 Radiation Therapy [D and I] 3.2.1 C ompare and contrast surgery versus definitive radiation therapy for early stage disease 3.2.2 S elect appropriate patients for adjuvant radiation therapy to the primary tumour and to the inguinal and pelvic lymph nodes 3.2.3 L ist the relative advantages and disadvantages of the different treatment techniques (photons, photons and electrons, and partial transmission blocks) used to treat the vulva and inguinal lymph nodes in continuity 3.2.4 D iscuss controversies surrounding elective treatment of inguinal lymph nodes, with either surgery or radiation therapy 3.2.5 D iscuss controversies surrounding central shielding of the vulva during elective treatment of inguinal and pelvic lymph nodes The trainee is able to discuss: 3.4 Systemic Therapy [G] 3.4.1 The indications for concurrent, platinumbased chemotherapy The trainee is able to discuss: 3.5 Other therapies [G] 3.5.1 The use of intra-vaginal chemotherapy or immune modifiers for Stage 0 disease 4 Outcomes [D] The trainee is able to describe: 4.1 Tumour 4.1.1 A management plan for local and/or distant recurrence depending on the previous treatment approach 4.2 Toxicity 4.2.1 The effect that treatment may have on sexual function (vaginal effects, menopause, and altered body image) and the management of these toxicities Gestational Trophoblastic Disease (GTD) 1 Oncology Sciences [D] The trainee is able to: 1.1 Pathology 1.1.1 D iscuss and define the heterogeneous group of lesions arising from abnormal proliferation of trophoblastic epithelium of the placenta 1.1.1.1 Benign trophoblastic lesions 1.1.1.2 Hydatidiform mole (partial, complete and invasive) 1.1.1.3 Gestational trophoblastic neoplasia: choriocarcinoma and placental site trophoblastic tumour 1.1.2 D escribe the pathogenesis of GTD i.e. from foetal tissue 1.1.3 Describe the significance of beta-HCG 1.1.4 D iscuss the pathology and natural history of malignant GTD after a non-molar pregnancy 1.2 Anatomy Page 72 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Describe the post-partum symptoms that warrant investigation 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Discuss routine HCG monitoring postpartum and the levels of HCG seen in presence of GTD 2.3.2 Discuss the use of investigations to assess uterine contents and to look for metastatic disease 2.3.3 Aware of the NIH classification of GTD, and WHO prognostic index score for GTD 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Evaluate the use of radiation therapy in the treatment of GTD (especially in the setting of high risk, poor prognostic metastatic GTD) 3.3 Surgery [G] 3.3.1 Discuss the indications for surgery 3.4 Systemic Therapy [G] 3.4.1 Discuss the indications for chemotherapy and the specific agents used 3.5 Other Therapies [G] 4 Outcome [D] The trainee is able to demonstrate understanding of: 4.1 Tumour 4.1.1 The importance of extent of disease at presentation, age, interval between the gestational event and persistent disease and serum beta-HCG levels 4.2 Toxicity 4.2.1 Issues related to contraception and future pregnancy during and following treatment for GTD © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement URINARY TRACT MAJOR FOCUS Bladder Cancer74 LESSER FOCUS Kidney and Ureter Cancer75 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 73 Bladder Cancer 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The concept and relevance of urothelial field change 1.2 Anatomy 1.2.1 R are variations e.g. hypotonic bladder, diverticuli, cystocoeles 2 Clinical Assessment [D and I] The trainee is able to describe the importance of: 2.1 History 2.1.1 P revious intravesical therapy 2.1.2 Irritable bladder symptoms 2.1.3 P re-treatment bladder capacity and function 2.2 Physical Examination The trainee is able to: 2.3 Investigation and Evaluation 2.3.1 E valuate the results of EUA, cystoscopy, bimanual palpation and TURB with bladder mapping and “random” biopsies 2.3.2 E xplain the importance of extent of CIS and presence of hydronephrosis 3Management 3.1 General [G] The trainee is able to: 3.2 Radiation Therapy [D and I] 3.2.1 S elect patients for bladder-conserving therapy 3.2.2 D escribe situations where partial bladder irradiation may be used as definitive radiation post-TURB or as boost after whole bladder treated for first phase 3.2.3 D iscuss the controversies associated with elective pelvic nodal irradiation 3.2.4 E valuate the utility of radiation therapy in treating high-risk, Grade 3 superficial disease Page 74 3.2.5 Describe historical data concerning the use of radiation therapy in the pre- and postoperative settings 3.2.6 Discuss the rationale and techniques available for adaptive radiotherapy, 3.2.7 Discuss the different palliative fractionation schedules The trainee is able to describe: 3.3 Surgery [G] 3.3.1 Discuss the use of of TURBT for superficial TCC/CiS 3.3.2 List the indications for partial cystectomy 3.3.3 List the indications for radical cystectomy 3.3.4 Describe the procedure of radical cystectomy in general terms (for males and females) and options for urinary diversion 3.3.5 Discuss the importance of complete/ maximal TURBT when organ-conserving approach employed 3.3.6 Evaluate the role of completion/salvage cystectomy following persistence or recurrence of muscle-invasive TCC after radiation treatment The trainee is able to describe: 3.4 Systemic Therapy [G] 3.4.1 The use of intravesical Bacillus CalmetteGuerin (BCG) and chemotherapy for superficial disease 3.4.2 The relative benefits of concurrent chemoirradiation[D] 3.4.3 The current status of neo-adjuvant and adjuvant chemotherapy 3.4.4 The benefits and limitations of palliative chemotherapy 3.5 Other Therapies [G] 4 Outcomes [D] The trainee is able to describe the: 4.1 Tumour 4.1.1 Importance of regular follow-up with urine cytology and cystoscopy following treatment of superficial disease 4.1.2 Risk of recurrence with superficial TCC/CIS following bladder conserving therapy and its further management 4.1.3 Recommended follow-up schedule for © 2012 RANZCR. Radiation Oncology Training Program Curriculum 4.2 Toxicity 4.2.1 M orbidities and impact on quality of life of surgical procedures, including urinary diversion Kidney and Ureter Cancer 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Highly variable natural history of renal cell carcinoma and immunological influences that may affect this 1.1.2 “Field change” concept relating TCC of the renal pelvis, ureter and bladder 1.2 Anatomy 1.2.1 Relevance of the horseshoe kidney 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Recognise the role of sequential CT scan assessment of size and appearance of renal lesions in predicting the diagnosis of renal cell carcinoma, need for intervention and risk of metastasis 2.3.2 Understand the limited role of needle or incisional biopsy and the risk of haemorrhage 2.3.3 Outline the use of ureteroscopy in evaluation of TCC of the ureter 3.2 Radiation Therapy [D and I] 3.2.1 Describe the indications for radiation therapy to the renal bed following nephrectomy 3.2.2 Discuss the variations in radiation therapy given for metastatic renal cell carcinoma depending on clinical presentation e.g. solitary metastases and long disease-free interval 3.3 Surgery [G] 3.3.1 Describe the primary role of surgery (radical nephrectomy – open and laparoscopic) in the management of renal cell carcinoma and TCC renal pelvis 3.3.2 Describe the role of (nephro)ureterectomy for TCC of the ureter 3.3.3 Discuss the indications for nephrectomy in a patient with metastatic disease 3.3.4 Describe the use of ureteric stenting 3.4 Systemic Therapy [G] 3.4.1 Describe the use of immunological agents e.g. interferon, interleukin, and molecularly targeted agents eg VEGF TK inhibitors 3.5 Other Therapies [G] 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 Describe the highly variable life expectancy and behaviour of renal cell carcinoma with and without treatment 4.2 Toxicity 3Management The trainee is able to: 3.1 General [G] © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 75 ROCKKS AND MES patients having bladder-conservation approach for muscle-invasive TCC, including the rationale, timing of biopsies and salvage operation if required Page 76 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement GASTROINTESTINAL TRACT MAJOR FOCUS Oesophageal Cancer78 Gastric Carcinoma78 Pancreatic Cancer79 Rectal Cancer80 Anal Cancer81 LESSER FOCUS Biliary Tract and Gall Bladder Cancers 82 Hepatocellular Carcinoma83 Gastrointestinal Stromal Tumours84 Carcinoid Tumour84 Colon Cancer85 Liver Metastases86 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 77 Oesophageal Cancer 1 Oncology Sciences [D] 3.2.3 The use of radiation therapy to the primary oesophageal tumour as palliative treatment for dysphagia The trainee is able to: 1.1 Pathology 1.1.1 C ompare and contrast the epidemiology, etiologic factors, and pathobiology of adenocarcinoma and squamous cell carcinoma of the oesophagus 1.1.2 D iscuss the rising incidence of adenocarinoma 1.1.3 D iscuss the association with synchronous head and neck primaries 1.1.4 L ist the common and uncommon histologies, including sarcoma, lymphoma, mucosal melanoma 3.3 Surgery [G] 3.3.1 The indications for definitive surgery with aim of cure 3.3.2 The importance of preservation of function 3.3.3 The common surgical procedures for attempted cure or palliation 1.2 Anatomy 1.2.1 D escribe the lymphatic drainage of the upper, mid and distal oesophagus 2 Clinical Assessment [D and I] The trainee can demonstrate : 4.1 Tumour 4.1.1 A knowledge of meta-analysis data evaluating preoperative chemoradiotherapy and preoperative chemotherapy and the expected treatment outcomes The trainee is able to: 2.1 History 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 D iscuss the limitations of staging investigations e.g. difficulty in assessment of depth of tumour invasion, and the role of endoscopic USS and PET 3.4 Systemic Therapy [G] 3.4.1 The use of chemotherapy alone or in combination with radiation, with the aim of cure, or palliation 3.4.2 The indications and relative benefits of combining chemotherapy with surgery 3.5 Other Therapies [G] 4 Outcomes [D] 4.2 Toxicity Gastric Carcinoma 1 Oncology Sciences [D] 3Management The trainee is able to describe: 3.1 General [G] 3.1.1 The controversies regarding Gastrooesophageal tumours and their management. 3.2 Radiation Therapy [D and I] 3.2.1 The indications and relative benefits of combining radiation therapy with surgery ie preoperative and postoperative 3.2.2 The indications for the use of radiation therapy as definitive treatment, alone or with systemic therapy Page 78 The trainee is able to describe the: 1.1 Pathology 1.1.1 WHO classification system of gastric tumours 1.1.2 Diffuse type and e-cadherin association 1.1.3 Other histologies: primary lymphoma, gastrointestinal stromal tumours (GIST) 1.2 Anatomy 1.2.1 The lymphatic drainage of stomach © 2012 RANZCR. Radiation Oncology Training Program Curriculum 4 Outcomes [D] The trainee is able to: 2.1 History 2.1.1 Describe the relative importance of: 2.1.1.1 L ocalising symptoms e.g. haematemesis, gastric outlet obstruction 2.1.1.2 C onstitutional symptoms e.g. weight loss and performance status The trainee is able to discuss: 4.1 Tumour The trainee is able to: 5.1 Evaluate the effectiveness of the Japanese screening program 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Demonstrate an understanding of the uses of various staging investigations e.g. endoscopy, CT scan, PET 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the indications for radiation therapy (± chemotherapy) preoperatively and postoperatively 3.2.2 Discuss the use of radiation therapy for palliation of inoperable local disease 3.3 Surgery [G] 3.3.1 Describe the indications for definitive surgical treatment 3.3.2 Discuss the different gastric and nodal resections and implications for staging 3.4 Systemic Therapy [G] 3.4.1 Discuss the use of pre- and post-operative chemotherapy 3.4.2 Debate the pros and cons of postoperative chemoradiation and perioperative chemotherapy 3.4.3 Knowledge of the use of Herceptin in metastatic gastric cancer 3.5 Other Therapies [G] 3.5.1 Describe the potential application of evolving therapies e.g. EGFR inhibitors © 2012 RANZCR. Radiation Oncology Training Program Curriculum 4.2 Toxicity 4.2.1 Treatment related toxicity in particular that of postoperative chemoradiation 5 Screening and Prevention [G] Pancreatic Cancer 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The differences between exocrine and endocrine tumours and subtypes 1.1.2 Molecular pathogenesis of pancreatic cancer 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Describe variations in presentation and distinguish from other causes of jaundice 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Select and evaluate relevant investigations, including EUS and biopsy 3Management 3.1 General [G] The trainee is able to discuss the: 3.2 Radiation Therapy [D and I] 3.2.1 Controversies in the use of radiation therapy (definitive and adjuvant), and variations in practice Page 79 ROCKKS AND MES 2 Clinical Assessment [D and I] The trainee is able to describe: 3.3 Surgery [G] 3.3.1 The indications for pancreaticoduodenectomy (Whipple’s procedure) 3.3.2 The indications for, and complications of, stenting The trainee is able to discuss the: 3.4 Systemic Therapy [G] 3.4.1 U se of chemotherapy as adjuvant treatment 3.4.2 P ros- and cons- of chemoradiation vs chemotherapy alone as definitive treatment for unresectable locally advanced pancreatic cancer 3.4.3 Indications for the use of chemotherapy alone as palliative therapy 4 Outcomes [D] 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.2.1 Perform a rectal assessment of the primary cancer and describe the tumour location, extent of stenosis, length of tumour, tethering and involvement of adjacent organs. 2.3 Investigation and Evaluation 2.3.1 Evaluate the different staging investigations including sigmoidoscopy and biopsy, colonoscopy, EUA, MRI, CT, and PET 2.3.2 Assess a patient’s fitness for curative therapy 3Management The trainee is able to: 4.1 Tumour 4.1.1 D escribe the expected rates of palliation in relation to specific symptoms 4.1.2 D escribe the expected median survival rates for surgery, chemoradiation and chemotherapy alone 4.2 Toxicity 4.2.1 Identify and manage malabsorption syndrome Rectal Cancer 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 C olorectal carcinogenesis – morphological, molecular and genetic changes and genetic testing 1.1.2 The Dukes’, MAC and AJCC (TNM) staging systems 1.1.3 Role and significance of microsatellite testing 1.2 Anatomy 1.2.1 The rectosigmoid junction and the mesorectal fascia Page 80 The trainee is able to: 3.1 General [G] 3.1.1 Discuss treatment options for stage l, ll, lll disease 3.1.2 Select patients for preoperative radiation therapy 3.1.3 Discuss treatment options for patients with simultaneous local and metastatic disease 3.1.4 Discuss treatment options for local recurrence 3.1.5 Discuss management of rectal cancer in elderly patients 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the advantages and disadvantages of pre- and post-operative radiotherapy 3.2.2 Discuss the evidence for and against short-course and long-course pre-operative radiation therapy 3.2.3 Explain the benefits of radiation therapy in palliative treatment 3.3 Surgery [G] 3.3.1 Describe common surgical approaches and their indications 3.3.2 Describe surgical field for total mesorectal excision © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3.3.3 D iscuss the role of palliative surgery e.g. diversion, stent 3.3.4 D iscuss the role of resection of solitary liver metastasis 3.4 Systemic Therapy [G] 3.4.1 D iscuss selection of patients for adjuvant and palliative chemotherapy 3.4.2 D escribe common adjuvant and palliative chemotherapy protocols 3.4.3 D iscuss the rationale for concurrent chemoradiation and list the commonly used regimens 3.4.4 D iscuss the role of biological agents 3.5 Other Therapies [G] 3.5.1 D iscuss the different treatment options used in the management of liver metastases e.g.RFA, SBRT, chemoembolisation, radioactive microspheres 3.5.2 Discuss the management of polyps 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 Discuss a follow up program after treatment of rectal cancer 4.2 Toxicity 4.2.1 Discuss management of acute side effects during chemoradiation 4.2.2 Discuss measures to anticipate and manage late effects of radiation therapy e.g. fertility, sexual dysfunction, early menopause, altered bowel functions 5 Screening and Prevention [G] The trainee is able to: 5.1 D iscuss screening programs for colorectal cancer in the general population and in high-risk groups 5.2 E xplain the relative merits of various screening tools: stool-testing, sigmoidoscopy, and colonoscopy 5.3 Explain the function of familial cancer clinics 5.4 C ounsel patients and their families regarding risk reduction in colorectal cancer © 2012 RANZCR. Radiation Oncology Training Program Curriculum Anal Cancer 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The importance of human papilloma virus (HPV), HIV, and immunosuppression 1.2 Anatomy 1.2.1 The lymphatic drainage of the anal canal 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.2.1 Perform a digital anorectal examination and assess the involvement of adjacent organs 2.2.2 Assess sphincter function 2.3 Investigation and Evaluation 2.3.1 Discuss staging for anal cancer with biopsy, EUA, CT, PET, endorectal ultrasound and MRI 2.3.2 Interpret CT and MRI scans 2.3.3 Describe the investigation of suspected malignant lymphadenopathy e.g. enlarged inguinal nodes 2.3.4 Recognise the importance of gynaecological assessment in female patients 3Management The trainee is able to: 3.1 General [G] 3.1.1 Describe treatment options for stage l, ll, lll and lV disease 3.1.2 Discuss the management of patients with HIV 3.1.3 Discuss the management of AIN 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the role of prophylactic nodal irradiation 3.2.2 Describe the different radiation therapy techniques eg conformal vs IMRT Page 81 ROCKKS AND MES including relevant doses for the primary tumour and prophylactic nodal regions 3.2.3 D iscuss the advantages and disadvantages of split course techniques 3.2.4 D iscuss the rationale for concurrent chemotherapy, and the common chemotherapeutic agents that are used 3.2.5 D iscuss salvage radiotherapy for isolated nodal recurrence 3.2.6 D iscuss the use of interstitial brachytherapy 3.3 Surgery [G] 3.3.1 Appreciate the principles of surgery where it is used in treating early disease; the importance of margins and the preservation of sphincter function 3.3.2 D escribe the role of defunctioning colostomy for locally advanced disease 3.3.3 D iscuss surgical salvage for persistent or recurrent local disease 3.3.4 D iscuss surgical salvage for nodal recurrence 3.4 Systemic Therapy [G] 3.4.1 D iscuss the benefits and increased toxicities associated with chemotherapy delivered concurrently with radiation therapy 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 D escribe a follow-up programme for patients treated with definitive chemoradiation. 4.1.2 D iscuss the role of biopsy and other investigations in follow-up after definitive chemoradiation 4.2 Toxicity 4.2.1 D iscuss management of acute effects during chemoradiation 4.2.2 E valuate anal dysfunction and the role of defunctioning colostomy 4.2.3 D iscuss measures to anticipate and manage late effects of radiation therapy e.g. fertility, sexual dysfunction, early menopause, altered bowel functions Page 82 4.2.4 Appreciate how toxicity might be modified by HIV infection Biliary Tract and Gall Bladder Cancers 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Diffusely invasive pattern of adenocarcinoma 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Be aware of the role of ERCP and imaging modalities designed to assess operability 2.3.2 Describe the limitations of tissue biopsy and the use of endoscopic USS guided biopsy 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the circumstances when external beam radiation therapy would be used definitively 3.2.2 Describe the varied roles, techniques and doses of brachytherapy i.e. boost in definitive treatment, and as a bile duct implant to prevent stenosis/restenosis [S] 3.2.3 Discuss potential benefits of concurrent chemoradiotherapy and the agents used 3.3 Surgery [G] 3.3.1 Describe the role of surgery, including the indications and techniques for stenting © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3.4 Systemic Therapy [G] 3.5 Other Therapies [G] 4 Outcomes [D] 4.1 Tumour 4.2 Toxicity Hepatocellular Carcinoma (HCC) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Differential diagnosis for a solitary liver lesion 1.1.2 Viral aetiology and impact of vaccination 1.2 Anatomy 1.2.1 Effect of respiratory motion 2 Clinical Assessment [D and I] The trainee is able to describe the importance of: 2.1 History 2.1.1 Performance status and co-morbidities 2.1.2 Previous treatment e.g. chemotherapy, and RFA 2.1.3 Extent of extrahepatic tumour burden 2.1.4 C o-existing liver disease and its impact on prognosis 2.2 Physical Examination The trainee is able to describe the: 2.3 Investigation and Evaluation 2.3.1 R elative benefits of CT, US, MR and PET imaging 3Management The trainee is able to: 3.1 General [G] 3.2.2 Describe the indications and technique for radical, high-dose focal radiation therapy including stereotactic body radiotherapy (HFRT)[G and S] 3.2.3 Describe radiation therapy in conjunction with transcatheter arterial chemoembolisation (TACE) [G] 3.3 Surgery [G] 3.3.1 Describe indications for surgical resection 3.3.2 Describe the role of liver transplantation 3.4 Systemic Therapy [G] 3.4.1 Describe systemic administration versus hepatic artery administration 3.4.2 Describe potential benefits of concurrent chemo-radiation with hepatic artery chemotherapy 3.5 Other Therapies [G] 3.5.1 Discuss evidence supporting use of molecularly targeted agents in treatment of unresectable disease 3.5.2 Discuss radiofrequency ablation (RFA) 3.5.3 Discuss radionuclides such as yttrium-90 microspheres (Sirtex spheres) or iodinelabelled lipiodol administered via hepatic artery 4 Outcomes [D] The trainee is able to describe: 4.1 Tumour 4.1.1 Response, local control and survival rates with radical and palliative treatments including palliative whole liver radiation therapy 4.2 Toxicity 5 Screening and Prevention [G] The trainee is able to discuss: 5.1 Screening for HCC 3.2 Radiation Therapy [D and I] 3.2.1 Describe the indications and technique for palliative radiation therapy © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 83 ROCKKS AND MES Gastrointestinal Stromal Tumours (GIST) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 C -kit proto-oncogene mutation Differentiation between sarcomaand GIST 1.1.2 Pattern of recurrence 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to describe the: 2.1 History 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 P rognostic features: site, size, mitotic rate, extent, imaging characteristics 3Management 4.1.1 Unreliability of survival data for this disease prior to 2000 due to misclassification of these tumours 4.2 Toxicity Carcinoid Tumour 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The importance of malignant carcinoid syndrome 1.1.2 The association with other familial or genetic disorders, such as multiple endocrine neoplasia type 1 (MEN 1) and Peutz-Jeghers syndrome 1.1.3 The importance of mitotic count/Ki67 in assessing different grades of carcinoid tumours 1.2 Anatomy 1.2.1 Presentations in non-gastrointestinal tract sites (lungs, mediastinum, thymus liver, pancreas, bronchus, and ovaries) The trainee is able to: 3.1 General [G] 2 Clinical Assessment [D and I] 3.2 Radiation Therapy [D and I] The trainee is able to: 2.1 History 3.3 Surgery [G] 3.4 Systemic Therapy [G] 3.4.1 D escribe mechanism of action of imatinib mesylate 3.4.2 D iscuss the role and action of other molecularly targeted agents for imatinib resistance 3.5 Other Therapies [G] 3.5.1 B e aware of use of radiofrequency ablation and embolisation techniques for unresectable liver metastases 2.2 Physical Examination 2.3 Investigation and Evaluation [G] 2.3.1 Evaluate the use of special diagnostic tests 2.3.1.1 Biogenic amines and metabolite measurements 2.3.1.2 Scintigraphy with MIBG and octreotide scanning 2.3.1.3 Radiotracers (Indium-111-labelled DTPA, Dota-octreotate (Gatate) PET) 3Management 4 Outcomes [D] The trainee is able to discuss: 3.1 General [G] The trainee is able to discuss the: 4.1 Tumour Page 84 3.2 Radiation Therapy [D and I] © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3.4 Systemic Therapy [G] 3.5 Other Therapies [G] 3.5.1 S omatostatin analogues (octreotide) for systemic and targeted treatment 3.5.2 Interferon alpha 3.5.3 Hepatic arterial embolisation 4 Outcomes [D] The trainee is able to describe: 4.1 Tumour 4.2 Toxicity 4.2.1 Carcinoid crisis Colon Cancer 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 Colorectal carcinogenesis – morphological, molecular and genetic changes and genetic testing 1.1.2 The Dukes’, MAC and AJCC (TNM) staging systems 1.2 Anatomy 1.2.1 The relationship of the colon to the peritoneum and retroperitoneum in its different segments 2 Clinical Assessment [D and I] The trainee is able to evaluate: 2.1 History 2.1.1 The significance of family history 3Management 3.1 General [G] The trainee is able to describe: 3.2 Radiation Therapy [D and I] 3.2.1 The situations where radiation therapy may be used as an adjunct to surgery The trainee is able to outline the procedures of and describe the indications for: 3.3 Surgery [G] 3.3.1 Colonoscopic polypectomy 3.3.2 Partial colonic resection 3.3.3 Total colectomy in high risk patients (familial adenomatosis polyposis (FAP) or ulcerative colitis with invasive cancer) 3.3.4 Metastatectomy e.g. hepatic resection for liver metastases; pulmonary metastatectomy in highly selected cases The trainee is able to demonstrate understanding of: 3.4 Systemic Therapy [G] 3.4.1 The role of combination chemotherapy in the adjuvant and palliative setting 3.4.2 The use and mechanisms of action of molecularly targeted therapies including VEGF inhibitors e.g. bevacizumab and EGFR inhibitors (including dependence on k-Ras status) 3.5 Other Therapies [G] 4 Outcomes [D] 4.1 Tumour 4.2 Toxicity 5 Screening and Prevention [G] The trainee is able to: 5.1 Identify family members at risk of colon cancer and refer them for genetic counseling 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Relevant diagnostic tests e.g. colonoscopy, CT scans, blood tests including chorioembryonic antigen (CEA) © 2012 RANZCR. Radiation Oncology Training Program Curriculum 5.2 Demonstrate awareness that the patient may be the index case in a familial syndrome 5.3 Describe the rationale for the general population screening program Page 85 ROCKKS AND MES 3.3 Surgery [G] 3.3.1 The indications for surgery with curative intent 3.3.2 The palliative value of de-bulking surgery Liver Metastases 1 Oncology Sciences [D] 3.5 Other Therapies [G] 3.5.1 Evaluate other therapeutic options e.g. arterial embolisation, cryotherapy, radiofrequency ablation The trainee is able to describe the: 1.1 Pathology 1.1.1 C ommon and uncommon primary sites associated with liver metastases 1.1.2 M echanisms of metastasis to the liver 1.2 Anatomy 1.2.1 P ortal circulation and the preference of gastrointestinal tract tumours to metastasise to the liver 1.2.2 D ivision of the liver into lobes and subsegments 3.4 Systemic Therapy [G] 4 Outcomes [D] 4.1 Tumour 4.2 Toxicity 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 S elect and evaluate the relevant diagnostic tests e.g. US and CT abdomen, liver biopsy, MRI 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 D iscuss situations where treatment with curative intent may be considered e.g. small, isolated metastasis in medically inoperable patient 3.2.2 S elect and plan patients for palliative liver irradiation [I] including high dose focal liver radiotherapy [S] 3.2.3 D iscuss the limited role of radio-isotope therapy e.g. Yttrium microspheres [G] 3.3 Surgery [G] 3.3.1 D escribe the indications for partial liver resection with curative intent Page 86 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement CENTRAL NERVOUS SYSTEM MAJOR FOCUS Adult Gliomas88 Meningioma89 Pituitary Tumours89 Medulloblastoma And Primitive Neuroectodermal Tumours90 Cerebral Metastases91 Malignant Spinal Cord Compression 92 LESSER FOCUS Ependymoma, Pineal and Germ Cell Tumours 93 Acoustic Neuroma 94 Cerebral Arteriovenous Malformations 95 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 87 Adult Gliomas 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The WHO classification system of primary brain tumours according to histology 1.1.2 The molecular genetics of formation of astrocytoma, transition to malignant glioma and response to treatment 1.2 Anatomy 1.2.1 N euro-anatomy in terms of the functional consequences of lesion location and relationships with other critical CNS structures 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 E licit symptoms of raised intracranial pressure 2.2 Physical Examination 2.2.1 Elicit signs of raised intracranial pressure 2.3 Investigation and Evaluation 2.3.1 S elect and interpret appropriate investigations e.g. CT, MRI, MRS and PET 2.3.2 Assess prognostic factors for clinical outcome (MRC and Radiation Therapy Oncology Group (RTOG) prognostic groups and EORTC nomograms) and explain how these aid treatment decision making may alleviate symptoms and optimise quality of life 3.1.3 Discuss the management of raised intracranial pressure 3.2 Radiation Therapy [D and I] 3.2.1 Select patients with high grade glioma for treatment with the aim of improving survival 3.2.2 Discuss the use of hypofractionated schedules in selected high grade glioma patients 3.2.3 Describe potential indications for specialised radiation therapy techniques e.g. stereotactic radiosurgery, fractionated stereotactic radiation therapy, and radioactive implantation 3.2.4 Discuss situations in which re-irradiation may be implemented in patients with progressive disease 3.3 Surgery [G] 3.3.1 Describe the indications for surgery and the factors that influence the extent of resection e.g. tumour site and imaging 3.3.2 Describe indications for other surgical procedures such as stereotactic biopsy and CSF shunting 3.3.3 Recognise situations where palliative surgery may be employed 3.4 Systemic Therapy [G] 3.4.1 Explain how agents may be integrated with radiation therapy, in particular glioblastoma muliforme [D] 3.4.2 Recognise the potential role of emerging systemic agents e.g. biological therapies 3Management The trainee is able to: 3.1 General [D] 3.1.1 E xplain the advantages and disadvantages of observation versus immediate therapy in patients with low grade gliomas; describe features that influence the timing of an intervention 3.1.2 R ecognise the role of supportive care alone for selected patients with high grade glioma and the palliative measures that Page 88 3.5 Other Therapies [D] 3.5.1 Describe the use of corticosteroids in managing the symptoms of raised intracranial pressure 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 Interpret diagnostic investigations such as CT or MRI after radiation therapy, © 2012 RANZCR. Radiation Oncology Training Program Curriculum 4.2 Toxicity 4.2.1 D escribe the importance of late effects of radiation therapy in the management of patients with low grade glioma Meningioma 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 WHO classification system 1.1.2 Explain the clinical significance of different pathological grades of meningioma 1.2 Anatomy 1.2.1 Common anatomical sites at which meningiomas arise and related critical structures 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Elicit clinical symptoms and describe focal deficits caused by meningiomas in specific locations 2.2 Physical Examination 2.3 Investigation and Evaluation 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Discuss radiation therapy in definitive, adjuvant and recurrent settings © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3.2.2 Discuss the indications for stereotactic radiation therapy 3.3 Surgery [G] 3.3.1 Discuss the utility of observation in patients with asymptomatic meningioma 3.3.2 Discuss the circumstances for maximal surgical resection 3.3.3 Describe situations where complete surgical resection is difficult, in particular, skull base and parasagittal meningiomas 3.4 Systemic Therapy [G] 3.4.1 Demonstrate an awareness of experimental treatments such as temozolomide, bevacizumab and hydroxyurea 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 Discuss the likelihood of local control with surgery alone (complete resection, incomplete resection), surgery and adjuvant radiation therapy, and radiation therapy alone 4.2 Toxicity 4.2.1 Describe potential long-term toxicities associated with radiation therapy and surgery Pituitary Tumours 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Differentiation between secretory and nonsecretory tumours 1.1.2 Differential diagnosis for a pituitary tumour (adult and paediatric) 1.2 Anatomy 1.2.1 Describe the structure of the pituitary gland 1.2.2 Discuss the importance of adjacent structures Page 89 ROCKKS AND MES including differentiation of recurrence from necrosis 4.1.2 D escribe the concepts of pseudoprogression and pseudo-response in the follow up of high-grade glioma, especially glioblastoma, and the implications for response assessment (RANO response criteria vs. the MacDonald criteria) 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 E licit the typical presenting features for the different pathological subtypes, including malignant tumours 2.2 Physical Examination 2.2.1 Assess the visual pathways to determine their possible involvement by tumour 2.3 Investigation and Evaluation 2.3.1 D escribe the macroscopic growth and neuro-endocrine effects of the tumour using a combination of clinical examination, blood tests and neuroimaging, including involvement of the cavernous sinus(es) and optic chiasm 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 O utline indications for radiation therapy, including pituitary carcinomas 3.2.2 E valuate the suitability of individual patients for stereotactic radiosurgery 3.3 Surgery [G] 3.3.1 R ecognise indications for urgent surgical decompression 3.3.2 L ist the contraindications to transsphenoidal surgery 3.4 Other Therapies [G] 3.4.1 D iscuss the appropriate use of medical management options (e.g. bromocriptine) for pituitary adenomas 4 Outcomes [D] The trainee is able to: 4.1 Tumour: 4.2 Toxicity 4.2.1 Identify patients for whom post-treatment Page 90 visual and endocrine assessment is appropriate 4.2.2 Identify and refer patients with radiation induced hypopituitarism 5 Screening and Prevention [D] The trainee is able to refer: 5.1 Patients with relevant family history for genetic counselling Medulloblastoma and Primitive Neuroectodermal Tumours (PNET) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Sporadic and familial occurrence of medulloblastoma and primitive neuroectodermal tumours (including Turcot’s and Golin’s syndrome) 1.2 Anatomy 1.2.1 Structures in and adjacent to the cerebrum, cerebellum, brainstem, spinal cord, spinal canal and dural reflections 1.2.2 Anatomical extent of the cererbro-spinal fluid spaces, including the optic nerves, meninges, spine and sacrum 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.2.1 Perform a neurological examination to assess mental state, cranial nerves, cerebellar function, motor and sensory function 2.3 Investigation and Evaluation [G and S] 2.3.1 Describe relative benefits of lumbar puncture, CT, MRI brain and spine 2.3.2 Assess prognostic factors for outcome, including age and histology 2.3.3 Explain how prognostic factor groupings aid treatment decision-making © 2012 RANZCR. Radiation Oncology Training Program Curriculum Cerebral Metastases The trainee is able to: 3.1 General [G] 1 Oncology Sciences [D] 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the relationship between radiation dose, fractionation and treatment outcome 3.2.2 Describe strategies for regions at risk of underdosage e.g. the cribiform plate 3.2.3 Explain junction techniques of co-planar and non co-planar beams for craniospinal irradiation 3.2.4 Discuss radiation techniques employed to reduce acute and late side effects with particular reference to the paediatric patient. 3.3 Surgery [G] 3.3.1 Communicate with neurosurgical colleagues regarding optimal management of individual patients 3.3.2 Explain the advantages and disadvantages of surgical intervention 3.4 Systemic Therapy [G] 3.4.1 Explain how, and which, drugs are commonly integrated with radiation therapy 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.2 Toxicity 4.2.1 Explain clinical consequences of radiation damage to the brain, brainstem, and growing tissues 4.2.2 Select and refer patients for rehabilitation 5 Screening and Prevention [G] The trainee is able to: 5.1 R ecognise a family history typical of Turcot’s and Gorlin’s syndrome 5.2 E xplain the screening procedures for patients with Turcot’s syndrome © 2012 RANZCR. Radiation Oncology Training Program Curriculum The trainee is able to describe: 1.1 Pathology 1.1.1 Common primary sites associated with brain metastases 1.1.2 Pathophysiology of brain metastases and leptomeningeal metastases 1.2 Anatomy 1.2.1 The relationship of site(s) of brain involvement to symptoms 2 Clinical Assessment [D and I] The trainee is able to evaluate: 2.1 History 2.2 Examination 2.3 Investigation and Evaluation 2.3.1 The role of MRI in defining the extent of disease and assessing eligibility for surgery. 2.3.2 The extent of systemic disease and its impact on treatment recommendations 3Management The trainee is able to: 3.1 General [G] 3.1.1 Discuss variations in management relating to the primary tumour type (including carcinoma of unknown primary), extent of brain metastases, and extent of systemic disease 3.1.2 Recognise situations where supportive care alone is most appropriate 3.2 Radiation Therapy [D and I] 3.2.1 Evaluate the use of external beam radiation therapy in patients with solitary brain metastasis (with or without surgery/radiosurgery) and multiple brain metastases 3.2.2 Evaluate the indications for, and techniques of, stereotactic radiation therapy /radiosurgery Page 91 ROCKKS AND MES 3Management 3.3 Surgery [G] 3.3.1 D escribe surgical options for diagnosis e.g. stereotactic biopsy, open brain biopsy, total or partial resection of metastases 3.3.2 U nderstand the contribution of surgery to the management of solitary and multiple brain metastases 3.3.3 R ecognise clinical situations for which urgent decompression surgery is required 2 Clinical Assessment [D and I] 3.4 Systemic Therapy [G] 3.4.1 D iscuss the concept of the brain as a sanctuary site in certain clinical situations 2.2 Physical Examination 2.2.1 Elicit signs of early and more advanced MSCC 3.5 Other Therapies [I] 3.5.1 P rescribe steroids, analgesia and anticonvulsants as required 3.5.2 Involve palliative care services 2.3 Investigation and Evaluation 2.3.1 Select suitable diagnostic tests and investigations for: 2.3.1.1 Situations where diagnosis of malignancy is known 2.3.1.2 Situations where there is no previous diagnosis of malignancy 2.3.1.3 Clarification of full extent of disease 2.3.2 Describe the importance of whole spine MRI 2.3.3 Describe patient and tumour factors influencing the approach to, and outcomes of treatment – including available models aimed at predicting patient outcomes 4 Outcomes [D] 4.1 Tumour 4.1.1 B e able to estimate survival based on known prognostic factors 4.2 Toxicity Malignant Spinal Cord Compression (MSCC) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 C lassification systems for the causes of cord compression including neoplastic (primary and secondary) and nonmalignant causes 1.1.2 P athophysiology of the clinical manifestations of cord compression including cord oedema and cord infarction 1.1.3 Acute and late radiation therapy changes in the spinal cord and research relating to spinal cord recovery 1.2 Anatomy 1.2.1 Implications of the position of the tumour within the vertebra e.g. body versus posterior elements and implications for surgical decompression Page 92 The trainee is able to: 2.1 History 2.1.1 Describe the chronology of symptoms associated with MSCC 2.1.2 Recognise and justify the emergency status of established MSCC and importance of impending MSCC 3Management The trainee is able to: 3.1 General [D] 3.1.1 Distinguish malignant spinal cord compression from cauda equina compression in terms of diagnosis and treatment 3.1.2 Describe general supportive measures such as analgesia, physiotherapy, bladder and bowel care 3.1.3 Describe the purpose, timing and dosage of steroid therapy 3.2 Radiation Therapy [D and I] 3.2.1 Discuss radiation therapy in MSCC management (alone and post-operative) 3.2.2 Recognise special cases of potentially curable or long-term controllable disease including plasmacytoma and lymphoma © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3.2.3 D iscuss the role of higher dose radiotherapy in patients with oligometastatic disease and good prognosis 3.3 Surgery [G] 3.3.1 Evaluate the use of surgery in diagnosis 3.3.2 D iscuss the indications for biopsy, laminectomy and vertebrectomy and/or stabilisation procedures 3.4 Systemic Therapy [G] 3.4.1 D iscuss the limited use of chemotherapy in MSCC as an alternative to radiation therapy or surgery e.g. lymphoma, paediatric tumours 3.5 Other Therapies [G] 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 Describe expected outcomes and goals of treatment 4.1.2 Explain options if there is neurological deterioration following initial therapy 4.1.3 Integrate other components of palliative care including rehabilitation where appropriate 4.2 Toxicity 4.2.1 Identify patient, tumour and treatment considerations for radiation therapy retreatment 5 Screening and Prevention [G] The trainee is able to: 5.1 E ducate patients at higher risk for developing MSCC about early warning symptoms and signs Ependymoma, Pineal and Germ Cell Tumours 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The histological classification of ependymoma (WHO grading system) and the most common sites of involvement in the CNS 1.1.2 The histological classification of pineal gland tumours (WHO classification). 1.1.3 The histological classification of intracranial germ cell tumours (WHO classification system) and the common sites of involvement in the CNS 1.2 Anatomy 1.2.1 The anatomical extent of the cerebrospinal fluid space 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.2.1 Perform a neurological examination to assess mental state, the cranial nerves, and cerebellar, motor and sensory function 2.3 Investigation and Evaluation 2.3.1 Select and interpret appropriate investigations such as lumbar puncture, CT, MRI of the brain and spine, and PET 2.3.2 Understand the significance of tumour markers and how to use them 2.3.3 Define prognostic factor grouping for a particular patient for the purposes of treatment decision making 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Explain the indications for localised and craniospinal irradiation © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 93 ROCKKS AND MES 3.2.2 E xplain the relationship between radiation dose, fractionation, control rates and the risk of complications 3.2.3 D emarcate the CSF spaces and develop strategies for regions at risk of under dosage, such as the cribriform plate 3.2.4 E xplain junction techniques of co-planar and non co-planar beams for craniospinal irradiation 3.3 Surgery [G] 3.3.1 C ommunicate with neurosurgeons regarding the optimal management of individual patients 3.3.2 L ist the advantages and disadvantages of surgical intervention 1.2.2 Anatomical pathways and functions of cranial nerves 2 Clinical Assessment [D and I] 2.1 History The trainee is able to perform: 2.2 Physical Examination 2.2.1 A neurological examination to assess mental state, cranial nerves V, VII, VIII, cerebellar function, motor and sensory function 2.3 Investigation and Evaluation 3Management 3.4 Systemic Therapy [G] 3.4.1 E xplain how agents may be integrated with radiation therapy 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 E xplain the special definition of local control i.e. lack of progression 4.1.2 E xplain risk of radiation-induced malignancy 4.2 Toxicity 4.2.1 E xplain clinical consequences of radiation damage to the brain, brainstem, and growing tissues 4.2.2 Select and refer patients for rehabilitation Acoustic Neuroma (AN) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Sporadic and familial occurrence of AN 1.2 Anatomy 1.2.1 S tructures in, and adjacent to, cerebellopontine angle and inner ear 1.2.1.1 Identify these structures on CT and MRI scans (transverse, sagittal and coronal slices) Page 94 The trainee is able to: 3.1 General [G] 3.1.1 Evaluate patients for active treatment versus observation 3.2 Radiation Therapy [D and I] 3.2.1 Explain the concept and rationale of stereotactic radiosurgery 3.2.2 Select patients for stereotactic versus conventional external beam therapy 3.2.3 Explain the relationships between radiation dose, fractionation (single vs. fractionated), incidence of control of AN and risk of complications 3.3 Surgery [G] 3.3.1 Communicate with neurosurgeon/ENT surgeon regarding optimal management of individual patients 3.3.2 List the advantages and disadvantages of surgical intervention 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 Explain the special definition of local control i.e. lack of progression 4.1.2 Explain risk of radiation-induced malignancy © 2012 RANZCR. Radiation Oncology Training Program Curriculum Cerebral Arteriovenous Malformations (AVMs) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Natural history of AVMs in relation to the risk of haemorrhage 1.1.2 Gross and microscopic structure of AVMs, including nidus and associated afferent and efferent vessels 1.1.3 Pathogenesis of luminal obliteration following radiation therapy 1.2 Anatomy 1.2.1 Cerebral vasculature and sketch a diagram or schema 1.2.2 Correlation of areas of brain parenchyma to vasculature 3.2 Radiation Therapy [D and I] 3.2.1 The concepts behind, and rationale for, stereotactic radiosurgery 3.2.2 The relationships between radiation dose, incidence of AVM ablation and risk of complications 3.3 Surgery [G] 3.2.1 The principles of, and indications for, treatment of AVMs with a surgical approach 4 Outcomes [D] The trainee is able to describe: 4.1 Tumour 4.1.1 The time course of ablation following radiosurgery 4.2 Toxicity 4.2.1 Clinical consequences of radiation necrosis or cerebral oedema of specific areas of the brain 4.2.2 The risk of radiation-induced malignancy 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.3 Investigation and Evaluation [G] 2.3.1 Discuss the importance of MRI and angiogram findings, with respect to treatment options and toxicity of treatment 3Management The trainee is able to demonstrate an understanding of: 3.1 General [G] © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 95 ROCKKS AND MES 4.2Toxicity 4.2.1 E xplain clinical consequences of radiation damage to the brainstem, and cranial nerves V - VIII 4.2.2 R efer patients with radiation-induced cranial nerve injury for surgical management Page 96 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement HAEMATOLOGY MAJOR FOCUS Hodgkin Lymphoma98 Non-Hodgkin Lymphoma 99 LESSER FOCUS Leukaemia100 Multiple Myeloma100 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 97 Hodgkin Lymphoma (HL) 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 WHO classification system 1.1.2 P athobiology and molecular pathology particularly where these relate to diagnosis 1.1.3 Infectious aetiopathogenesis 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Identify B symptoms and alcohol intolerance 2.2 Physical Examination 2.2.1Perform a thorough examination of the lymphoreticular system. 2.3 Investigation and Evaluation 2.3.1 Describe appropriate staging investigations including the role of PET 2.3.2 S tratify patients according to contemporary prognostic groupings 2.3.3 D escribe the Cotswolds staging classification i.e. modified Ann Arbor 3.2 Radiation Therapy [D and I] 3.2.1 Detail contemporary combined modality therapy and the historical changes in the role of radiation therapy in the curative treatment of HL 3.2.2 Describe involved field and involved nodal radiation, including the planning principles of post-chemotherapy radiation 3.2.3 Understand geometric uncertainties as they apply to image fusion 3.2.4 Describe the role and key planning principles of other radiation therapy techniques e.g. mantle field, subtotal nodal irradiation, total nodal irradiation, extended field, and total body irradiation (TBI) 3.2.5 Determine the role of salvage radiation therapy for chemotherapy treatment failures 3.2.6 Describe the role of radiotherapy following salvage chemotherapy and autograft 3.3 Surgery [G] 3.3.1 Describe the historic role of staging laparotomy in the context of the natural history of HL 3.4 Systemic Therapy [G] 3.4.1 Discuss the role of chemotherapy, and the common regimens used, in the curative and palliative settings 3.4.2 Discuss the use of high-dose chemotherapy 3Management The trainee is able to: 3.1 General [D] 3.1.1 D istinguish the utility of fine needle biopsy versus core biopsy versus excision biopsy 3.1.2 D iscuss the impact of pregnancy on management decisions, including the significance of gestational stage and special psychosocial issues (see Breast page 44 for detailed learning outcomes) 3.1.3 Advise patients regarding fertility management and family planning in relation to their cancer 3.1.4 E xplain the clinical significance of pathological subtypes of HL and how they affect treatment choice Page 98 3.5 Other Therapies [G] 3.5.1 Discuss the role of bone marrow transplant 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.2 Toxicity 4.2.1 Discuss how late effects (including secondary malignancy) influence the evolution of treatment strategies 4.2.2 Describe follow-up of patients specifically with regard to monitoring for late effects and their management © 2012 RANZCR. Radiation Oncology Training Program Curriculum 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The rationale for classification schemes i.e. WHO classification 1.1.2 Pathobiology and molecular pathology particularly where these relate to diagnosis including cytogenetics 1.1.3 Features distinguishing special sites i.e. orbital lymphoma, testicular lymphoma, MALT-type (extra-nodal marginal zone) lymphoma, primary bone lymphoma, primary cutaneous lymphoma (PBCL/PTCL), primary CNS lymphoma, and HIV-related lymphoma 1.1.4 Infectious aetio-pathology 1.2 Anatomy 1.2.1 Lymph node regions as related to Ann Arbor staging system 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Elicit a history and risk profile for immunosuppression e.g. HIV/AIDS 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Evaluate molecular and cytogenetic studies indicating B or T-cell origin 2.3.2 Describe appropriate staging investigations (including PET, bone marrow biopsy) 2.3.3 Stratify patients according to contemporary prognostic groupings 3.2 Radiation Therapy [D and I] 3.2.1 Describe involved field radiation therapy including the planning principles of the post-chemotherapy radiation field 3.2.2 Describe treatment principles for extranodal lymphomas 3.2.3 Describe the indications and techniques for applying fields extending beyond “involved field” radiation therapy, including subtotal nodal irradiation, total nodal irradiation and TBI 3.2.4 Understand geometric uncertainties as they apply to image fusion 3.2.5 Describe the role of radiotherapy following salvage chemotherapy and autograft 3.3 Surgery [G] 3.3.1 Discuss the role of surgery in diagnostic biopsy and definitive treatment of NHL e.g. MALT-type (extra-nodal marginal zone) lymphoma and primary CNS lymphoma 3.4 Systemic Therapy [G] 3.4.1 Discuss the roles of chemotherapy and radiation therapy in low grade NHL 3.4.2 List commonly used chemotherapy agents and regimens (current and historical) 3.4.3 Evaluate the use of high-dose chemotherapy and bone marrow transplant 3.4.4 Discuss the role of molecularly targeted agents and radioimmunotherapy 3.5 Other Therapies [G] 3.5.1 Discuss the role of other forms of treatment eg triple therapy for H. pylori related gastric MALT-type (extra-nodal marginal zone) lymphoma, corticosteroids 3.5.2 Discuss CNS prophylaxis 4 Outcomes [D] 3Management The trainee is able to: 3.1 General [G] 3.1.1 Discuss the impact of pregnancy on management decisions, including the significance of gestational stage and special psychosocial issues (see Breast page 44 for detailed learning outcomes) © 2012 RANZCR. Radiation Oncology Training Program Curriculum The trainee is able to describe the: 4.1 Tumour 4.2 Toxicity 4.2.1 Discuss how late effects (including secondary malignancy) influence the evolution of treatment strategies Page 99 ROCKKS AND MES Non-Hodgkin Lymphoma (NHL) 4.2.2 D escribe follow-up of patients specifically with regard to monitoring for late effects and their management 3.2.2 Explain the practical considerations of the above techniques 3.2.3 Describe the use of radiotherapy for granulocytic sarcoma [chloroma] 5 Screening and Prevention [G] The trainee is able to: 5.1 E xplain the role of H. pylori screening and eradication in MALT-type (extra-nodal marginal zone) lymphoma Leukaemia 1 Oncology Sciences [D] 3.3 Surgery [G] 3.4 Systemic Therapy [G] 3.5 Other Therapies [G] 3.5.1 Discuss the evolving role of biological therapies e.g. imatinib, dasatinib in chronic lymphoid leukaemia (CML) 4 Outcomes [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Genetic abnormalities 1.1.2 Infective precursors 1.1.3 M utagenic therapies associated with development of leukaemia The trainee is able to: 4.1 Tumour 4.1.1 Discuss the importance of close follow-up and the measurement of minimum residual disease 1.2 Anatomy 4.2 Toxicity 2 Clinical Assessment [D and I] Multiple Myeloma The trainee is able to: 2.1 History 1 Oncology Sciences [D] 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 E valuate relevant diagnostic tests, including molecular and cytogenetic studies e.g. indicating Ph+ disease 2.3.2 D escribe significance of minimal residual disease and the duration of disease remission The trainee is able to describe the: 1.1 Pathology 1.1.1 Differences between Monoclonal Gammopathy of Undetermined Significance (MGUS), solitary plasmacytoma in both osseus and extraosseus sites and multiple myeloma 1.1.2 Discuss the wide variation in clinical presentation of plasma cell neoplasms 1.2 Anatomy 3Management 2 Clinical Assessment [D and I] The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 D escribe uses of radiation therapy, including indications for cranial, craniospinal or total body irradiation in both myeloablative and non myeloablative transplants and total marrow irradiation Page 100 The trainee is able to: 2.1 History 2.2 Physical Examination 2.3 Investigations and Evaluations 2.3.1 Select and evaluate diagnostic tests including serum IgG and IgA, creatinine, © 2012 RANZCR. Radiation Oncology Training Program Curriculum calcium, urinary protein excretion, and radiology (skeletal survey, CT, and MRI) ROCKKS AND MES 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the differences in PTV and prescription for solitary plasmacytoma compared to multiple myeloma 3.2.2 Discuss the use of hemi-body radiation therapy 3.3 Surgery [G] 3.3.1 Discuss the indications for spinal surgery 3.4 Systemic Therapy [G] 3.4.1 Discuss the use of chemotherapy as the primary treatment modality, including the most effective regimens, timing of interventions with systemic therapies 3.5 Other Therapies [G] 3.5.1 Describe the use of bisphosphonates in multiple myeloma 3.5.2 Describe the evolving role of immunotherapy and currently used biological agents 3.5.3 Describe the role of transplantation 4 Outcomes [D] The trainee demonstrates knowledge of: 4.1 Tumour 4.1.1 The measurement of response to systemic therapies 4.1.2 The impact of site of plasmacytoma on risk of progression to multiple myeloma 4.2 Toxicity 5 Screening and Prevention [G] The trainee demonstrates knowledge of: 5.1 The importance of regular monitoring of patients with solitary plasmacytoma © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 101 Page 102 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement MUSCULOSKELETAL AND CONNECTIVE TISSUE MAJOR FOCUS Soft Tissue Sarcoma104 Bone Metastases105 LESSER FOCUS Primary Tumours Of The Bone106 Aggressive Fibromatosis106 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 103 Soft Tissue Sarcoma 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The spectrum of malignancy from benign to malignant and the differential diagnosis between these entities 1.1.2 The main histological subgroups of sarcomas and their specific immunohistochemical features and chromosome abnormalities 1.1.3 The AJCC staging system 1.1.4 P redisposing factors (eg genetic predisposition) 1.2 Anatomy 1.2.1 The location of major neurovascular bundles and fascial planes in relation to muscle “compartments” 2 Clinical Assessment [D and I] The trainee is able to : 2.1 History 2.1.1 E licit symptoms arising from tumour compression of surrounding structures 2.2 Physical Examination 2.2.1 Assess the extent of the tumour and its relationship to surrounding structures (eg fixity, relationship to neurovascular structures) 2.2.2 Assess any functional deficit caused by the tumour or treatment 2.3 Investigation and Evaluation 2.3.1 D iscuss optimal biopsy techniques and the considerations behind the placement of surgical scars 2.3.2 E valuate staging investigations including CT, MRI/MRA, bone scan, and PET 3.2 Radiation Therapy [D and I] 3.2.1 The role of radiation therapy in curative (including definitive, pre- and postoperative, and salvage) and palliative situations 3.2.2 The advantages and disadvantages of preoperative versus postoperative radiation therapy 3.2.3 Special considerations when defining the planning target volume, specifically: 3.2.3.1 Patient set-up for the treatment of various limb compartments 3.2.3.2 Indications for elective nodal irradiation 3.2.3.3 Individualised use of bolus, including rationale 3.3.4 The role of intra-operative radiation treatment, brachytherapy and IMRT 3.3 Surgery [G] 3.3.1 The role and indications for surgery in biopsy, local excision, and compartmentectomy versus amputation 3.3.2 The importance of wide surgical margins 3.3.3 The potential morbidity and impact on quality of life following surgery 3.4 Systemic Therapy [G] 3.4.1 The role of systemic therapy in the curative and palliative settings 3.5 Other Therapies [G] 4 Outcomes [D] The trainee is able to: 4.1 Tumour 4.1.1 Describe the prognostic factors for distant, local recurrence and survival 4.2 Toxicity 4.2.1 Measure functional outcome following treatment and contribute to planning a suitable rehabilitation program 3Management The trainee is able to describe: 3.1 General [G] 3.1.1 The importance of multidisciplinary evaluation and management Page 104 © 2012 RANZCR. Radiation Oncology Training Program Curriculum 1 Oncology Sciences [D] The trainee is able to: 1.1 Pathology 1.1.1 List common and less common primary sites 1.1.2 Recognise the appearance and natural history of metastases according to primary site 1.1.3 Describe the mechanisms of bone metastasis 1.2 Anatomy 1.2.1 Appreciate anatomical implications for the position of metastases e.g. neck of femur, adjacent nerves 1.2.2 Describe the typical distribution of bone metastases within the skeleton and the reasons for this e.g. prostate cancer and the vertebral bodies and pelvis 2 Clinical Assessment [D and I] The trainee is able to 2.1 History 2.1.1 Describe different types of bone pain e.g. neuropathic 2.1.2 Describe measures and scales of the severity of pain 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Select suitable investigations for suspected bony metastases 2.3.2 Describe the mechanism by which bone scans detect lesions and recognise diseases where a bone scan may not show bone metastases e.g. myeloma 2.3.3 Understand the principles of pathological diagnosis if bone metastases are the first presentation of cancer 3Management The trainee is able to: 3.1 General [D] © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3.1.1 Demonstrate an understanding of treatment intent and likely outcomes 3.1.2 Integrate methods of symptom management of bone metastases with other components of palliative care 3.1.3 Select patients at higher risk for spinal cord compression and educate them accordingly 3.1.4 Demonstrate knowledge of the prevention of pathological fractures 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the role of single vs multi fraction treatment schedules for uncomplicated bone metastases 3.2.2 Discuss the emerging role of high dose stereotactic radiation in the setting of oligometastatic disease and re-irradiation ie spinal metastases. 3.2.3 Discuss the role of hemibody radiotherapy 3.2.4 Identify patients for re-irradiation 3.2.5 Quantify fracture risk and subsequent impact on dose/fractionation 3.3 Surgery [G] 3.3.1 Describe the role of surgery in diagnosis 3.3.2 Describe the role of surgery in the prevention and treatment of pathological fracture 3.4 Systemic Therapy [G] 3.4.1 Describe the potential benefit and use of radioisotope therapy 3.5 Other Therapies [D and I] 3.5.1 Demonstrate an ability to manage bone pain with pharmacological agents 3.5.2 Demonstrate an understanding of the mechanism of action, indications for and evidence for use of bisphosphonates and RANK ligand inhibitors 4 Outcomes [D] 4.1 Tumour 4.2 Toxicity 4.2.1 Describe the phenomenon of acute bone pain flare following radiotherapy Page 105 ROCKKS AND MES Bone Metastases Primary Tumours of the Bone 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Bi-modal age distribution 1.1.2 S ites of various tumours in relation to the epiphysis 1.1.3 Classification of tumours 1.1.4 D ifferences in mode of spread for different tumours e.g. aneurysmal bone tumour vs. osteosarcoma 1.2 Anatomy 1.2.1 Importance of neurovascular supply and lymphatics 2 Clinical Assessment [D and I] The trainee is able to discuss the: 2.1 History 2.2 Physical Examination 2.3 Investigation and Evaluation 2.3.1 Importance of pathology review 2.3.2 Use of CT, MRI, bone and PET scans 2.3.3 P lain radiographic appearances e.g. starburst, onion-skin 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Select patients for radiation therapy 3.3 Surgery [G] 3.3.1 D escribe indications for (considering advantages and disadvantages) limb conservation and amputation 3.5 Other Therapies [G] 3.5.1 Discuss the indications for embolisation 4 Outcomes [D] The trainee is able to describe: 4.1 Tumour 4.2 Toxicity 4.2.1 Functional and cosmetic outcomes 4.2.2 Specific issues for paediatric patients e.g. growth potential, second malignancy Aggressive Fibromatosis 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 The relationship to soft tissue trauma (e.g. surgery), familial adenomatous polyposis of colon, and Gardner’s syndrome 1.2 Anatomy 1.2.1 The most common anatomical sites of disease 2 Clinical Assessment [D and I] The trainee is able to elicit: 2.1 History 2.1.1 The functional impact of disease and treatments The trainee is able to perform: 2.2 Physical Examination 2.2.1 A functional assessment of disease and impact of therapy The trainee is able to discuss: 2.3 Investigation and Evaluation 2.3.1 The importance of margin status 2.3.2 The place of CT, large volume MRI (assessment of multifocality) 3.4 Systemic Therapy [G] 3.4.1 E valuate use of neo-adjuvant chemotherapy 3.4.2 D escribe uses of intra-arterial chemotherapy Page 106 © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3Management 3.1 General [G] ROCKKS AND MES The trainee is able to describe: 3.2 Radiation Therapy [D and I] 3.2.1 Indications for adjuvant and definitive settings 3.2.2 The role of observation in situations where post-operative margins are involved 3.2.3 The importance of large margins on CTV, especially longitudinally The trainee is able to discuss: 3.3 Surgery [G] 3.3.1 The indications for biopsy and local excision 3.3.2 The importance of wide resection margins The trainee is able to discuss: 3.4 Other Therapies [G] 3.4.1 Reported responses to other therapies e.g. tamoxifen, steroids, non-steroidal antiinflammatory drugs, imatinib (Glivec) 4 Outcomes [D] The trainee is able to discuss expected outcomes of treatment relating to: 4.1 Tumour 4.2 Toxicity 4.2.1 Potential functional and cosmetic morbidity of surgery 4.2.2 Morbidity of adjuvant or definitive radiation therapy, especially in the paediatric population © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 107 Page 108 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement PAEDIATRICS LESSER FOCUS Paediatric Cancers110 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 109 Paediatric Cancers 1 Oncology Sciences [D] The spectrum of paediatric cancer is unique because it is not defined by histological entity but by age (generally accepted as <16 years). The trainee is able to describe: 1.1 Pathology 1.1.1 The RB gene, and the syndromes associated with Wilms’ tumours 1.1.2 Variations in differentiation of “small round blue cell tumours”, and differences in natural history and modes of spread Although paediatric patients and tumours are infrequently seen in a Radiation Oncology practice, the fundamental reasons for all trainees achieving a good level of knowledge in this area are: 1. S o that trainees develop an appreciation of managing malignancy in the developing child, focusing on the long-term consequences of treatment choices, in particular “survivorship” 2. S o that trainees consider issues related to delegated consent It should be appreciated that both survivorship and consent issues also occur in adult oncology but are usually of a lesser focus. The management of children with differing cancers follows a basic pattern of minimising radiation with its potent long-term consequences whilst maintaining or improving cure. This is well illustrated by the changes in the management of Acute Lymphocytic Leukeamia (ALL) and Hodgkin’s Lymphoma, particularly when contrasted with the adult setting. The specific malignancies that trainees should have most detailed knowledge of are: • “Developmental” Malignancies: Retinoblastoma; Neuroblastoma; Wilms’ tumour • Haematological Malignancies: ALL; Hodgkin’s Lymphoma • Musculoskeletal Malignancies: Rhabdomyosarcoma; Ewing’s Sarcoma; Osteosarcoma; • CNS Malignancies: Medulloblastoma; Ependymoma; Brain Stem Glioma; Other Gliomas; CNS Germ Cell Tumours At the end of this section, following the general headings, are key learning objectives relating to each of these malignancies. In addition, the trainee is advised to refer to other relevant MES. Page 110 1.2 Anatomy 1.2.1 Anatomical variations from adult e.g. skeleton 2 Clinical Assessment [D] The trainee is able to describe the importance of: 2.1 History 2.1.1 Familial cancers 2.1.2 Developmental status in management decisions 2.1.3 Second malignancies 2.2 Physical Examination The trainee is able to evaluate relevant diagnostic tests, specifically: 2.3 Investigation and Evaluation 2.3.1 Understand the role of CNS evaluation in ALL, parameningeal RMS, and CNS tumours 2.3.2 Understand the roles of MRI and PET in staging sarcomas and brain tumours 2.3.3 Understand the impact of treatment on fertility, tissue growth, and neuropsychological development 2.3.4 Describe the relevant prognostic factors and risk groupings 3Management 3.1 General [G] The trainee is able to describe: 3.2 Radiation Therapy [D] 3.2.1 Immobilisation of children and infants, including anaesthesia 3.2.2 Considerations for planning target volume 3.2.3 Importance of tolerance of organs at risk © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3.2.4 S tandard doses and fractionation schedules 3.2.5 D ose escalation and altered fractionation 3.2.6 U se of special techniques – IMRT, brachytherapy, stereotactic, TBI 3.2.7 Use of radiation for palliation The trainee is able to describe the: 3.3 Surgery [G] 3.3.1 R ole and extent of surgery, as part of overall management The trainee is able to: 3.4 Systemic Therapy [G] 3.4.1 D escribe the role, and timing, of chemotherapy in conjunction with other treatments 3.4.2 D emonstrate knowledge of the common drugs used for the specific malignancies listed The trainee is able to describe the: 3.5 Other Therapies [G] 3.5.1 U se of agents such as retinoic acid in neuroblastoma, and steroids in haematological and CNS malignancies 4 Outcomes [D] In reference to the following specific tumour histologies, the trainee is able to describe the significance of: 6.1 Retinoblastoma 6.1.1 The RB gene and the impact of Knudson’s “two-hit hypothesis” in understanding carcinogenesis 6.1.2 The implications of optic nerve and/or scleral involvement 6.2 Neuroblastoma 6.2.1 Embryonic neural crest cell maturation and consequent limitations of infant screening 6.2.2 The impact of N-Myc amplification and the use of biological markers to guide therapy 6.2.3 The use of MIBG for staging and therapy 6.3 Wilms’ 6.3.1 Differences between the SIOP and National Wilms’ Tumour Study (NWTS) approach to management 6.3.2 “Favourable” versus “unfavourable” histology 6.4 Acute Lymphocytic Leukaemia 6.4.1 Defining children in the “high-risk” category 6.4.2 CNS preventive therapy including CSI 4.1 Tumour The trainee is able to discuss the risks, management and prevention of: 4.2 Toxicity 4.2.1 Acute and late morbidity of radiation and other treatment, in particular, growth and developmental issues (including neuropsychological), fertility and second malignancy 4.2.2 The above treatment toxicities with the patient and family 5 Screening and Prevention [G] The trainee is able to describe: 5.1 The use of genetic testing, and involvement of the familial cancer service 6 Tumour Specific Points 5.2 The rationale for long-term follow-up and “late effects clinics” © 2012 RANZCR. Radiation Oncology Training Program Curriculum 6.5 Hodgkin’s Lymphoma 6.5.1 PET in defining involved fields 6.5.2 Issues specific to adolescent patients 6.6 Rhabdomyosarcoma (RMS) 6.6.1 Nodal spread 6.6.2 So-called “favourable” sites of RMS 6.6.3 Sequencing therapy for parameningeal RMS 6.6.4 Differences in European (SIOP) and North American (COG) management approaches 6.7 Ewing’s Sarcoma 6.7.1 Distinguishing this disease from PNET 6.7.2 Associated chromosomal abnormalities 6.8 Osteosarcoma 6.8.1 The association with the RB gene 6.8.2 Isolated metastases e.g. to lung and management thereof Page 111 ROCKKS AND MES 6.9 Medulloblastoma 6.9.1 Gene expression profiles and prognosis 6.9.2 H igh and average risk categories and influence on management 6.9.3 H ydrocephalus and relationship to neurocognitive function 6.10 Ependymoma 6.10.1 Gene expression profiles and prognosis 6.10.2 B aby brain study outcomes and controversy surrounding benefit of radiation therapy 6.10.3 C hoice of local versus craniospinal irradiation 6.11 Brain Stem Glioma 6.11.1 The classical diffuse infiltrating pontine tumour in paediatric setting 6.11.2 R isks of obtaining histological confirmation 6.11.3 This diagnosis in relation to urgency of treatment 6.11.4 Temozolamide as part of treatment regimen 6.12 Other Gliomas 6.12.1 The option of observation for NF-1 and visual pathway gliomas 6.12.2 J uvenile pilocystic astrocytoma (JPA) in relation to timing and dose of radiation therapy 6.12.3 H igh grade gliomas and management issues in the paediatric setting LiFraumeni syndrome in connection with gliomas 6.13 Intracranial Germ Cell Tumours 6.13.1 D ifferentiating lesions from other suprasellar pathologies 6.13.2 H istorical “test” dose radiation therapy (to confirm germ cell origin) 6.13.3 E mploying whole ventricle treatment in comparison with CSI 6.13.4 S ystemic therapy options and their sequencing with radiation therapy Page 112 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement ENDOCRINE MAJOR FOCUS Thyroid Cancer114 LESSER FOCUS Adrenal Tumours114 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 113 Thyroid Cancer 1 Oncology Sciences [D] The trainee demonstrates knowledge of the: 1.1 Pathology 1.1.1 C ompare and contrast the epidemiology, risk factors, presentation, histology and the biological behaviour of the different pathological subtypes (papillary carcinoma, follicular carcinoma, medullary carcinoma, and anaplastic carcinoma) 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to elicit: 2.1 History 2.1.1 P rognostic determinants, in particular age groups 2.2 Physical Examination The trainee is able to select and interpret diagnostic tests and staging investigations including: 2.3 Investigations and Evaluations 2.3.1 B lood investigations e.g. thyroid function tests, thyroglobulin, and calcitonin 2.3.2 Imaging e.g. radionuclide scan and CT 3Management The trainee is able to: 3.1 General [G] 3.1.1 D escribe different treatment approaches for different pathological subtypes of thyroid cancer 3.1.2 D iscuss the impact on treatment decisions in the situation of the pregnant patient (refer to Breast page 44 for detail of learning outcomes) 3.2 Radiation Therapy [D and I] 3.2.1 D iscuss the use of radioactive iodine and involvement of the endocrinologist in papillary and follicular carcinoma 3.2.2 D escribe external-beam radiation therapy techniques Page 114 3.3 Surgery [G] 3.3.1 Describe surgical techniques for the relief or prevention of respiratory obstruction 3.3.2 Discuss the indications for total thyroidectomy versus partial thyroidectomy 3.3.3 Describe the role of neck dissection 3.4 Systemic Therapy [G] 3.4.1 Acknowledge the limited role of conventional cytotoxic chemotherapy and discuss the role for targeted therapies 4 Outcomes [D] The trainee demonstrates knowledge of the: 4.1 Tumour 4.1.1 Differences in prognosis for the different pathological subtypes of thyroid cancer 4.2 Toxicity 4.2.1 Toxicity of radiation therapy treatment, radioactive iodine and surgery 4.2.2 Use of medical therapy for hormone deficiency [G] 5 Screening and Prevention [G] The trainee demonstrates knowledge of the: 5.1 Situations where prophylactic thyroidectomy and screening for phaeochromocytoma in MEN II families would be recommended Adrenal Tumours 1 Oncology Sciences [D] The trainee is able to describe the: 1.1 Pathology 1.1.1 Importance of MEN (multiple endocrine neoplasia) syndromes 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination © 2012 RANZCR. Radiation Oncology Training Program Curriculum 2.2.1 Describe the following clinical syndromes: 2.2.1.1 C ushing’s syndrome 2.2.1.2 C onn’s syndrome ROCKKS AND MES 2.3 Investigation and Evaluation 2.3.1 Interpret blood and urine tests to assess the adrenal status 2.3.2 Describe the radiological features of benign and malignant tumours 2.3.3 Discuss the importance of nodal involvement and inferior vena cava (IVC) involvement 3Management The trainee is able to: 3.1 General [G] 3.1.1 Discuss the management of electrolyte and hormone imbalances 3.1.2 Discuss the control of blood pressure 3.2 Radiation Therapy [D and I] 3.2.1 Discuss the indications for adjuvant radiation therapy 3.2.2 Discuss the use of radiation for palliation 3.3 Surgery [G] 3.3.1 Describe the utility of surgery in early stage disease and palliation 3.4 Systemic Therapy [G] 4 Outcomes [D] 4.1 Tumour 4.2 Toxicity 5 Screening and Prevention [G] The trainee is able to: 5.1 Identify families at risk of MEN and refer appropriately for genetic counselling © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 115 Page 116 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement METASTATIC DISEASE MAJOR FOCUS Metastatic Carcinoma of Unknown Primary Site 118 LESSER FOCUS Metastases at Sites Not Otherwise Specified 118 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 117 Metastatic Carcinoma of Unknown Primary Site 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 C ommon patterns of lymphatic and haematogenous spread 1.1.2 C ytological, histological and immunohistochemical features that assist in determining the primary site 1.1.3 The role of tumour markers 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 E licit clinical features that may aid in identification of the likely primary 2.2 Physical Examination 2.2.1 Identify where specialised examination techniques may be required e.g. nasendoscopy 2.3 Investigation and Evaluation 2.3.1 S elect and interpret appropriate investigations, including biopsy techniques, aimed at identification of subtypes of malignancy e.g. carcinoma versus lymphoma: adenocarcinoma versus squamous cell carcinoma 2.3.2 E xplain the importance of histological confirmation of malignancy 3Management The trainee is able to discuss: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 The need, on rare occasions, to commence treatment prior to the completion of a full diagnostic work-up, even potentially without histological confirmation e.g. spinal cord compression, airway compromise Page 118 3.2.2 Situations where radiation therapy management of an occult primary may be undertaken with curative intent e.g. squamous cell carcinoma metastatic to parotid gland or cervical lymph nodes: adenocarcinoma metastatic to axillary lymph nodes 3.3 Surgery [G] 3.4 Systemic Therapy [G] 4 Outcomes [D] The trainee is able to describe: 4.1 Tumour 4.1.1 The differing prognoses dependent on the probable primary 4.2 Toxicity Metastases at Sites Not Otherwise Specified The rationale for this as a separate topic is to emphasise the principles of palliation employing nonpharmacological modalities. Note that management of metastases is also dealt with in the tumour site topics and in separate bone, brain and liver metastases sections. 1 Oncology Sciences [D] The trainee is able to describe: 1.1 Pathology 1.1.1 Unusual patterns of metastatic spread that prompt need for histological confirmation e.g. isolated lung tumour in the setting of an otherwise low-risk previous breast cancer; cerebral tumours following previous prostate cancer 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.1.1 Recognise clinical features that assist in assessing performance status 2.2 Physical Examination © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES 2.3 Investigation and Evaluation 2.3.1 Select and interpret appropriate investigations including biopsy techniques to confirm the presence of disease, histology and define disease extent 2.3.2 Explain the importance of histological confirmation of metastases in certain situations (as above) 3Management The trainee is able to: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 Recognise the impact of Eastern Cooperative Oncology Group (ECOG) performance status, weight loss, histology, and volume of disease on radiation schedules 3.3 Surgery [G] 3.3.1 Identify situations where metastectomy may be appropriate 3.3.2 Evaluate palliative surgical interventions e.g. stenting 3.4 Systemic Therapy [G] 3.4.1 List agents, regimens and modes of delivery that are most efficacious for palliation, according to histology and site of metastatic spread 3.4.2 Liaise with medical oncology team regarding appropriate sequencing of therapy 4 Outcomes [D] The trainee is able to discuss: 4.1 Tumour 4.1.1 The likelihood of particular symptoms responding to local palliative therapy 4.1.2 The differing prognoses dependent on the cancer type, disease-free-interval, site of metastases and how this influences therapy and follow-up 4.2 Toxicity © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 119 Page 120 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement NON-MALIGNANT LESSER FOCUS Non-Malignant Diseases Treated With Radiation Therapy 122 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 121 Non-Malignant Diseases treated with Radiation Therapy It is expected that the following benign diseases are studied in detail – • heterotopic bone ossification (HBO) • keloid scarring • pterygium • Grave’s ophthalmopathy (hyperthyroid eye disease) Some non-malignant conditions that fit within a siteoriented supplement will be covered elsewhere e.g. pituitary adenoma, acoustic neuroma and non-malignant tumours of bone. There are a number of other non-malignant conditions where radiation is occasionally used. It is not expected that these are studied in detail. 1 Oncology Sciences [D] 3.3 Surgery [G] 3.4 Systemic Therapy [G] 3.5 Other Therapies [G] 3.5.1 Alternative options for management and their effectiveness e.g. non-steroidal antiinflammatory agents in HBO; steroids for keloid scars and Grave’s ophthalmopathy 4 Outcomes [D] The trainee is able to discuss the: 4.1 Non-malignant disease 4.1.1 Benefits of various treatments 4.2 Toxicity 4.2.1 Incidence, histopathology, natural history and features of radiation-induced malignancies The trainee is able to discuss: 1.1 Pathology 1.1.1 B enign conditions that have historically been treated with radiation therapy e.g. ankylosing spondylitis, Peronie’s disease, synovitis 1.1.2 P athophysiology of benign processes that are treated with radiation therapy 1.2 Anatomy 2 Clinical Assessment [D and I] The trainee is able to: 2.1 History 2.2 Physical Examination 2.3 Investigation and Evaluation 3Management The trainee is able to discuss: 3.1 General [G] 3.2 Radiation Therapy [D and I] 3.2.1 The timing of radiation therapy in relation to surgery Page 122 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ROCKKS AND MES MEDICAL EXPERT Medical Expert Supplement CLINICAL ONCOLOGY MAJOR FOCUS Symptom Control124 Quality Of Life 125 It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 123 Symptom Control 2 Management [D and I] Cancer pain 1 Clinical Assessment [D and I] 2.1 Understand that the cause of dyspnoea is often multifactorial and that treatment is dictated by the suspected cause 1.2 D escribe the location of dermatomes 2.2 Pharmacological management 2.2.1 Assess suitability for and prescribe medication to treat dyspnoea e.g. steroids, opiates, anticoagulation and benzodiazapines 1.3 Assess the patient and select or review investigations in order to determine the likely causes and severity of the pain 2.3 Non-Pharmacological management 2.3.1 Assess suitability for blood transfusion, pleural tap, pleurodesis, and paracentesis The trainee is able to: 1.1 D iscuss the causes of cancer pain i.e. somatic, visceral, neuropathic and psychological [G] 2 Management [D and I] Nausea and Vomiting 1 Clinical Assessment [D and I] 2.1 U nderstand that a multidisciplinary approach is often required to achieve adequate analgesia 2.2 Pharmacological management 2.2.1 P rescribe non-opiate and common opiate analgesics; choose the most appropriate drug and route of administration 2.2.2 Anticipate and manage potential side effects of common analgesics e.g. constipation, nausea 2.2.3 D escribe the role of adjuvant analgesics e.g. steroids, anti-epileptics, antidepressants, bisphosphonates 2.2.4 Assess response to a chosen analgesic regimen and select patients for referral to a palliative care or pain specialist 2.3 Non-Pharmacological management [G] 2.3.1 D escribe common anaesthetic and palliative surgical procedures that may be used to control pain Dyspnoea 1 Clinical Assessment [D and I] The trainee is able to: 1.1 Discuss the causes of cancer-related and treatment-related nausea and vomiting 1.2 Assess the patient and select or review investigations to determine the likely cause and severity of nausea or vomiting 2 Management [D and I] 2.1 Understand the multi-factorial nature of nausea and vomiting 2.2 Pharmacological management 2.2.1 Assess suitability for, and prescribe, appropriate medication e.g. hydroxytryptamine receptor blockers (5HT3), dopamine antagonists, haloperidol, steroids and aperients 2.3 Non-pharmacological management 2.3.1 Select patients for palliative surgical procedures to treat uncontrolled nausea and vomiting The trainee is able to: 1.1 Discuss the causes of cancer-related dyspnoea 1.2 Assess the patient and select or review investigations in order to determine the likely cause(s) and severity of the dyspnoea Page 124 © 2012 RANZCR. Radiation Oncology Training Program Curriculum 1 Clinical Assessment [D] The trainee is able to: 1.1 L ist the risk factors for cancer patients developing depression or anxiety 1.2 D iscuss the difficulties associated with diagnosis of depression in the cancer patient 1.3 D escribe the cognitive symptoms of depression that aid in diagnosis Quality of Life (HR-QoL) The purpose of this section is to emphasise the importance of addressing health-related quality of life (HR-QoL) during the assessment of patients, communication with patients and their carers and during the formulation of a suitable management plan. In addition, an understanding of the importance of choosing appropriate quality of life end points and employing suitable measurement tools to assess these endpoints, both as part of clinical trials as well as in the evaluation of “standard” treatment programs, is fundamental to the optimal practice of oncology. 2 Management [D and I] Specifically, the trainee is able to describe and discuss: 1 Principles of Quality of Life [G] 2.1 U nderstand that depression and anxiety in the cancer patient is best managed by a combination of drugs, supportive psychotherapy and cognitive-behavioural techniques 1.1 Working definitions for health-related HR-QoL 1.2 The potential influence that HR-QoL factors may have on treatment related decision-making by patients, carers and doctors 1.3 How consideration of short-term versus longterm quality of life may differ with treatment intent and patient factors - e.g. significant acute side effects causing a temporary deterioration in HR-QoL may be acceptable in the potentially curative treatment of a young man with metastatic testis cancer but not in an elderly patient with co-morbidities and very low chance of cure 1 Clinical Assessment [D] The trainee is able to: 1.1 D escribe the symptoms and signs associated with hypercalcaemia 1.4 The approach to discussion of the impact of radiation therapy and other interventions / therapies on HR-QoL 1.5 The particular relevance of HR-QoL issues when balancing the possibilities of active treatment against no treatment in the palliative and terminal phases of disease 2.2 S elect patients for referral for psychiatric assessment 2.3 Pharmacological management [G] 2.3.1 List commonly used anti-depressants and understand that in the setting of advanced disease, the selection of drug is dependent on the type of depressive symptoms, intercurrent medical problems and the drug side effect profiles Hypercalcaemia 1.2 Assess hydration and renal function 2 Management [D and I] 2.1 S elect patients for, and prescribe, appropriate rehydration and bisphosphonate therapy 2.2 Evaluate response to therapy © 2012 RANZCR. Radiation Oncology Training Program Curriculum 2 Measurement of Quality of Life [G] 2.1 One or two commonly used instruments for the measurement of aspects of HR-QoL in oncology and the basic format and scope of each of these e.g. SF-36 (a global HR-QOL measure for use in patients with any disease, the European Page 125 ROCKKS AND MES Depression and Anxiety Organisation for the Research and Treatment of Cancer (EORTC) QLQ-C30 (a global measure of HR-QOL in all cancer patients), QLQ-BR23 (a breast cancer specific module), , hospital anxiety and depression scale (HADS) or other 2.2 The basic process for the development and evaluation of HR-QoL instruments, including validation and analysis of data (in simple terms) 2.3 K ey HR-QoL concepts that are relevant to consider in varying clinical contexts such as when measuring the efficacy of a given treatment or in the setting of clinical trial development. eg. Perceptions of body image after breast cancer treatments, or sexual function in prostate cancer 2.4 The meaning of health-related HR-QoL “domains” in HR-QoL measurement 2.5 The concept and examples of “trade-offs” pertaining to Oncology 2.6 The concept of “utility” of treatment options 2.7 The meaning of HR-QoL-adjusted life years (QALYs) and how these may be employed in comparison of treatment regimens Page 126 © 2012 RANZCR. Radiation Oncology Training Program Curriculum LEARNING OPPORTUNITIES MEDICAL EXPERT Learning Opportunities It is essential that this Medical Expert Supplement (MES) be used in conjunction with the ROCKSS document (page 39). MES direct the trainee to areas of study that are in some way particular or unique to the topic in question. In contrast, the ROCKSS competencies form the core requirements for all topics, regardless of tumour site or clinical scenario. © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 127 MEDICAL EXPERT LEARNING OPPORTUNITIES 1New patients seen as inpatients or outpatients 3.3 Prepare treatment summaries 3.4 Obtain feedback on referrals to other health professionals 3.5 Receive appraisal of performance by radiation therapists, physicists, medical oncologists and nurses The trainee may, under consultant supervision: 1.1 Assess new patients 1.2 D iscuss treatment recommendations with patient and family 1.3 Review tests and referrals 1.4 S ubmit a specific dose and fractionation schedule 1.5 O btain feedback on presentation of patients at MDT 1.6 Reflect on new patients seen and treatment planned 1.7 Dictate letters and reports 2 Follow up patients The trainee may, under consultant supervision: 2.1 Assess patients under active follow up 2.2 C onduct an audit of documentary record of findings 2.3 C onduct an audit of recommended treatments for symptom control and toxicity 2.4 Counsel a patient and family 2.5 C onduct an audit of referrals to other specialists and health professionals 3 Treatment review The trainee may, under consultant supervision: 3.1 Assess patients during course of radiation therapy and manage toxicities 3.2 C onduct an audit of documentation of diagnosis and management of acute toxicities Page 128 4 Inpatient Care The trainee may, under consultant supervision: 4.1 Assess patients and make decisions regarding management 4.2 Discuss treatment recommendations with patient and family 4.3 Review tests results 4.4 Reflect on patients seen and treatment planned 4.5 Review, and seek feedback on, documentation of patient care 4.6 Present patients on ward rounds, and receive feedback 4.7 Conduct an audit of patient care or discharge planning 5Radiation Therapy Planning and Treatment The trainee may, under consultant supervision: 5.1 Submit a provisional radiation therapy treatment prescription 5.2 Contour structures, and receive feedback 5.3 Critically appraise treatment plans 5.4 Reflect on radiation therapy treatment plans 5.5 Participate in simulator sessions, including using planning software 5.6 Participate in physics tutorials regarding treatment techniques and quality assurance © 2012 RANZCR. Radiation Oncology Training Program Curriculum 5.7 Review treatment verification 5.8 Complete a planning module 5.9 Outline response to set-up errors 5.10 O bserve and discuss specific methods in brachytherapy e.g. gynaecological, prostate 6.14 Complete a rotation within medical oncology and palliative care LEARNING OPPORTUNITIES 6 Other learning opportunities The trainee may: 6.1 Engage in self-directed study e.g. reading 6.2 D iscuss oncology issues with a Radiation Oncologist 6.3 P articipate in departmental and state-wide tutorials 6.4 Participate in hospital grand rounds 6.5 E ngage in on-line and other computer-based learning activities e.g. attend a literature searching course, learn to use reference manager soft-ware, undertake a Cochrane Library users course 6.6 Participate in journal clubs 6.7 Participate in MDT meetings 6.8 P articipate in special meetings e.g. examination preparation courses, paediatric course, scientific meetings 6.9 Supervise and teach attached junior medical staff, medical students, nurses and radiation therapists 6.10 C onduct a literature review or internet search, relating to patients seen or for research 6.11 S pend rostered time on treatment machines 6.12 S pend rostered time in planning with radiation therapists and physicists 6.13 O bserve surgical and interventional procedures © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 129 Page 130 © 2012 RANZCR. Radiation Oncology Training Program Curriculum © 2012 RANZCR. Radiation Oncology Training Program Curriculum COMMUNICATOR COMMUNICATOR Page 131 Page 132 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Role 2: Communicator The Radiation Oncologist: • Establishes a professional relationship with the patient and their family, and is sensitive to their illness, social situation and cultural background • Is expert in eliciting and synthesising relevant history and patient preferences by directed questioning and effective listening • Discusses information with patients, their families and their health care team, using appropriate language • Maintains ethical and effective verbal and written communication with other practitioners, in all roles 1 Patients and significant others The trainee is able to: 1.1 Learning Outcomes 1.1.1 Obtain adequate information from the patient to formulate a history, diagnosis and management plan 1.1.2 Identify and explore the patient’s issues and concerns within the scope of a focussed consultation 1.1.3 Discuss with the patient and relatives/ carers the implications of the patient’s cancer, the stage of the disease, the prognosis, treatment options, complications and supportive care in a clear, honest and empathetic manner 1.1.4 Explain and manage issues that arise from diagnostic or therapeutic uncertainty 1.1.5 Recognise and respect the differing needs of patients for a variety of levels of information and degrees of participation in management decisions 1.1.6 Provide an environment in which the patient can ask questions and seek guidance about other treatments 1.1.7 Ascertain the patient’s and carer’s understanding of the information provided 1.1.8 Explain details of radiation therapy planning and the treatment process (e.g. physical isolation during treatment) 1.1.9 Recognise and manage patient anxiety 1.1.10 Obtain informed consent and document information on which consent is based 1.1.11 Demonstrate specific communication skills required to deal with emotional © 2012 RANZCR. Radiation Oncology Training Program Curriculum reactions of patients and families e.g. denial, anger 1.1.12 Satisfy privacy and confidentiality requirements as they pertain to the individual 1.1.13 Demonstrate awareness of, and communication skills to deal effectively with, patients from culturally and linguistically diverse backgrounds 1.1.14 Discuss with the patient and significant others the implications of familial cancer clinics and genetic testing The trainee may: 1.2 Learning Opportunities 1.2.1 Conduct a consultation with a patient and their family, and receive feedback from an observer 1.2.2 Counsel a palliative patient and their family regarding prognosis, and receive feedback from an observer 1.2.3 Reflect on a patient interview where informed consent for treatment or participation in a clinical trial was obtained 1.2.4 Participate in family conferences 1.2.5 Complete formal communication skills training, especially in the areas of breaking bad news, dealing with uncertainty and preparing a patient for potentially injurious interventions 1.2.6 Complete a course on working with interpreters 1.2.7 Participate in tutorials and role plays on end of life issues 1.2.8 Discuss with a clinical psychologist common problems for cancer patients Page 133 COMMUNICATOR Role Statement e.g. dealing with uncertainty, anxiety, claustrophobia, panic disorder 1.2.9 Attend teaching sessions on cultural variations in beliefs about, and responses to, illness and death 2 Other health professionals 3.1.2 Use language appropriate to the audience and the topic The trainee may: 3.2 Learning Opportunities 3.2.1 Speak to community or patient groups about aspects of cancer care, and receive feedback The trainee is able to: 2.1 Learning Outcomes 2.1.1 P resent the patient’s problems succinctly and accurately to colleagues, listen to other health professionals’ opinions and contribute to consensus decisions 2.1.2 E xplain how radiation therapy fits into the overall management plan, including the potential benefits and side effects 2.1.3 S eek advice from clinical colleagues where their expertise may contribute to a better outcome 2.1.4 C ommunicate with other professional groups (e.g. radiation therapists, physicists, managers, administrators) to achieve optimal patient care The trainee may: 2.2 Learning Opportunities 2.2.1 B e appraised by radiation therapists, physicists, medical oncologists and nurses 2.2.2 P resent patients at multidisciplinary team meetings and reflect on outcomes, and discuss these with colleagues 2.2.3 P resent at educational meetings and obtain feedback 2.2.4 P resent cases to a clinical supervisor and receive feedback 2.2.5 S upervise and teach medical students, nurses and radiation therapists 2.2.6 D ictate letters and reports for review by a clinical supervisor 3 The community The trainee is able to: 3.1 Learning Outcomes 3.1.1 Talk with a range of community groups e.g. patient support groups, interest groups, school students, medical students, and the media Page 134 © 2012 RANZCR. Radiation Oncology Training Program Curriculum COLLABORATOR COLLABORATOR © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 135 Page 136 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Role 3: Collaborator Role Statement The Radiation Oncologist: • Establishes and maintains interpersonal co-operative relationships with patients • Establishes and maintains interpersonal co-operative relationships with other healthcare providers • Facilitates optimal patient care both in the out-patient and inpatient setting • Participates in research and educational activities The trainee is able to: 1.1 Learning Outcomes 1.1.1 Work with the patient and others to find common goals 1.1.2 Co-ordinate services 1.1.3 Support cancer patients and their families The trainee may: 1.2 Learning Opportunities 1.2.1 Observe and discuss senior colleagues’ interactions with patients 1.2.2 Attend other interdisciplinary cancerrelated consultations (e.g. psychology services) 1.2.3 Conduct family conferences 1.2.4 Participate in cultural awareness training 1.2.5 Compile a list of local support services 1.2.6 Attend and participate in cancer support groups 2 Other health professionals The trainee is able to: 2.1 Learning Outcomes 2.1.1 Seek colleagues’ opinions, both formally and informally 2.1.2 Respond constructively to feedback 2.1.3 Co-ordinate care with general practitioners 2.1.4 Develop and implement clinical guidelines The trainee may: 2.2 Learning Opportunities 2.2.1 Participate in formal and informal performance appraisal 2.2.2 Participate in a mentoring program 2.2.3 Develop a management and follow-up plan with a general practitioner 2.2.4 Read current intra-departmental guidelines © 2012 RANZCR. Radiation Oncology Training Program Curriculum 2.2.5 Participate in review and implementation of new guidelines 3 Multidisciplinary patient care The trainee is able to: 3.1 Learning Outcomes 3.1.1 Co-ordinate services 3.1.2 Inform other specialties of the role of radiation therapy 3.1.3 Explore treatment alternatives 3.1.4 Work with other specialties and allied health staff to arrive at an optimal patientfocused management program 3.1.5 Develop and implement evidence-based guidelines The trainee may: 3.2 Learning Opportunities 3.2.1 Participate in and organise team meetings 3.2.2 Work with other medical and allied health staff to ensure optimal case management 3.2.3 Present at team meetings 3.2.4 Discuss management options in a multidisciplinary setting 3.2.5 Review and synthesise new evidence for presentation 3.2.6 Participate in the development of guidelines 4 Research and clinical trials groups The trainee is able to: 4.1 Learning Outcomes 4.1.1 Contribute to the design, conduct and analysis of research activities 4.1.2 Support and participate in local and multicentre studies and trials Page 137 COLLABORATOR 1 Patient and significant others The trainee may: 4.2 Learning Opportunities 4.2.1 C omplete the training research requirement 4.2.2 Recruit to clinical trials 4.2.3 Attend clinical trials meetings e.g. TROG Scientific Meeting 4.2.4 P articipate in the collection of clinical trial data 4.2.5 P resent their own research for the Varian prize 5 Education stakeholders The trainee is able to: 5.1 Learning Outcomes 5.1.1 E ngage constructively with other education stakeholders to provide teaching in Oncology 5.1.2 P articipate in RANZCR meetings and activities The trainee may: 5.2 Learning Opportunities 5.2.1 Attend review meetings of local teaching programs 5.2.2 D esign teaching content, based on the requirements of universities 5.2.3 O rganise and prepare trainee teaching programs 5.2.4 Act as a Trainee Representative on local and RANZCR committees 6 Health managers The trainee is able to: 6.1 Learning Outcomes 6.1.1 Work with health managers and colleagues to ensure the best use of available resources The trainee may: 6.2 Learning Opportunities 6.2.1 D raw up a trainee roster for cover and educational activities 6.2.2 P articipate in departmental management committees 6.2.3 C ollect and present information relating to resource management to inform departmental policy Page 138 © 2012 RANZCR. Radiation Oncology Training Program Curriculum MANAGER MANAGER © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 139 Page 140 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Role 4: Manager Role Statement The Radiation Oncologist: • Optimises decisions regarding individual patient care in the context of finite health care resources • Provides leadership in healthcare organisations • Ensures effective work practices through staffing and the development of policies and procedures based on appropriate use of information systems 1Resources The trainee is able to: 1.1 Learning Outcomes 1.1.1 Describe budgetary considerations in an established Radiation Oncology department 1.1.2 Consider resource limits when ordering investigations for individual patients 1.1.3 Evaluate and explore alternative methods of patient investigation and treatment on behalf of the department 1.1.4 Evaluate the use of clinical guidelines to assist patient care 1.1.5 Manage waiting times, including the prioritisation of patients for evaluation and treatment 1.1.6 Demonstrate an understanding of quality assurance and accreditation activities within a Radiation Oncology department 1.1.7 Collect activity data to inform decisions regarding service provision e.g. when to build a new department 1.1.8 Describe issues to consider in the establishment and maintenance of databases 1.1.9 Describe the process and costs involved in establishing a new Radiation Oncology department The trainee may: 1.2 Learning Opportunities 1.2.1 Participate in departmental staff and business meetings 1.2.2 Order appropriate and optimally sequenced investigations for a patient 1.2.3 Assign waiting time priorities according to departmental protocols 1.2.4 Attend a time management course 1.2.5 Attend a business management course 3Technologies © 2012 RANZCR. Radiation Oncology Training Program Curriculum 1.2.6 Participate in quality assurance and accreditation activities of the department 1.2.7 Review jurisdictional and national cancer strategies 1.2.8 Participate in departmental activity data collection and review The trainee is able to: 2.1 Learning Outcomes 2.1.1 Display skills in conflict resolution 2.1.2 Display skills in the management of trainees 2.1.3 Display leadership skills 2.1.4 Chair clinical and non-clinical meetings The trainee may: 2.2 Learning Opportunities 2.2.1 Attend training sessions on conflict resolution 2.2.2 Manage trainee rosters 2.2.3 Be active in taking up leadership opportunities e.g. Trainee Representative on RANZCR committees 2.2.4 Participate in performance management e.g. assessor in multi-source feedback activities 2.2.5 Participate in staff selection committees The trainee is able to: 3.1 Learning Outcomes 3.1.1 Actively participate in the assessment, development, installation and application of new technologies 3.1.2 Describe the features of electronic information systems as applied to Radiation Oncology Page 141 MANAGER 2People 3.1.3 D emonstrate understanding of data storage options and discuss advantages and limitations The trainee may: 3.2 Learning Opportunities 3.2.1 Attend discussions, and join committees, regarding new technologies 3.2.2 Teach colleagues to use new technologies 3.2.3 Attend information technology teaching sessions 3.2.4 Investigate the information system operating in their own training department 3.2.5 U ndergo training in the use of electronic records and retrieval of results 3.2.6 Visit other centres to investigate their use of new technologies Page 142 © 2012 RANZCR. Radiation Oncology Training Program Curriculum HEALTH ADVOCATE HEALTH ADVOCATE © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 143 Page 144 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Role 5: Health Advocate Role Statement The Radiation Oncologist: • Applies expertise and influence, whether individually or as part of a group, to improve cancer services on behalf of individual patients, groups of people with cancer and the community at large 1 Patient and Significant Others The trainee is able to: 1.1 Learning Outcomes 1.1.1 Advocate for the patient in a multidisciplinary clinic 1.1.2 Recognise, and help overcome, barriers to treatment 1.1.3 Be aware of, and facilitate access to, support services and resources 1.1.4 Demonstrate awareness of the processes for securing resources for patient care 1.1.5 Promote patient safety 1.1.6 Demonstrate knowledge of potential mismatches between evidence and regulations controlling drugs and other treatments 2.1.3 Discuss cancer-related public health policy e.g. community screening programs 2.1.4 Contribute to public fora e.g. media, public debates The trainee may: 2.2 Learning Opportunities 2.2.1 Speak at support group meetings and public forums 2.2.2 Join a cancer organisation 2.2.3 Volunteer to participate in cancer organisation activities, including fundraising events HEALTH ADVOCATE The trainee may: 1.2 Learning Opportunities 1.2.1 Attend, and present at, multidisciplinary clinics 1.2.2 Attend hospital and departmental orientation sessions 1.2.3 Attend Occupational Health and Safety meetings 1.2.4 Read hospital and departmental safety protocols 1.2.5 Identify personnel responsible for safety and patient representation in the local setting 2 The Community The trainee is able to: 2.1 Learning Outcomes 2.1.1 Access cancer-related community organisations e.g. Cancer Council, government, cancer institutes 2.1.2 Speak to community groups e.g. cancer support groups, Apex, schools © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 145 Page 146 © 2012 RANZCR. Radiation Oncology Training Program Curriculum SCHOLAR SCHOLAR © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 147 Page 148 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Role 6: Scholar Role Statement 1 Students and Trainees The trainee is able to: 1.1 Learning Outcomes 1.1.1 Mentor students and other trainees 1.1.2 Participate in departmental academic programs and teaching sessions 1.1.3 Assist other trainees in examination preparation 1.1.4 Provide and obtain feedback on all areas of performance The trainee may: 1.2 Learning Opportunities 1.2.1 Lead teaching sessions for students, trainees and other staff 1.2.2 Supervise teaching programs 1.2.3 Present educational topics to peers and senior medical staff 1.2.4 Read medical literature 1.2.5 Participate in journal clubs 1.2.6 Act as a mock examiner and provide feedback 1.2.7 Give advice regarding examination preparation and technique 2 Critical Appraisal and Statistics The trainee is able to: 2.1 Learning Outcomes 2.1.1 Explain common research terminology e.g. hypotheses, endpoints, outcomes, incidence, prevalence, biases 2.1.2Contrast types of research design e.g. controlled clinical trials, case-control studies, historical and concurrent controls, blind and double-blind studies 2.1.3 Discuss the advantages and © 2012 RANZCR. Radiation Oncology Training Program Curriculum disadvantages of randomised controlled clinical trials 2.1.4 Define phases [I - III] of clinical trials 2.1.5 Define and describe the importance of different outcome measures e.g. overall survival, disease-free survival, time to progression, quality of life 2.1.6 Evaluate different methods of calculating survival 2.1.7 Discuss levels of significance, types of errors and power calculations 2.1.8 Discuss the relative benefits of various statistical methods and tests e.g. Chi-squared, logistic regression 2.1.9 Explain study limitations and how they may affect conclusions/outcomes 2.1.10 Describe key principles of meta-analyses and systematic reviews 2.1.11 Define and describe levels of evidence 2.1.12 Demonstrate awareness of the importance of ethics in human experimentation, as defined by National Health and Medical Research Council (NHMRC) national statement and the Helsinki declaration 2.1.13 Critically appraise published literature and other research-related documents 2.1.14 Demonstrate familiarity with guidelines for the reporting of research studies 2.1.15 Demonstrate knowledge of principles of peer-review process The trainee may: 2.2 Learning Opportunities 2.2.1 Attend a course on critical appraisal 2.2.2 Attend local journal club meetings 2.2.3 Read the information on critical appraisal and basic statistics that is provided on the RANZCR website Page 149 SCHOLAR The Radiation Oncologist: • Engages in life-long learning with the goal of continuously improving his or her mastery of the discipline • Contributes to the collection, analysis and interpretation of data that relate to health care quality and outcomes • Critically evaluates scientific literature and research • Integrates emerging evidence into clinical practice • Participates in the education of peers, trainees, other health care providers, and community bodies • Actively participates in advancing knowledge in the clinical and laboratory settings 2.2.4 R eview statistical methodology of a scientific article 2.2.5 Analyse and present analysis, verbally or in writing, of their research results 2.2.6 U ndertake units of relevant post-graduate study in statistics and critical appraisal e.g. as part of M Clinical Epidemiology or similar 3 Role Model The trainee is able to: 3.1 Learning Outcomes 3.1.1 D emonstrate enthusiasm in teaching and learning roles 3.1.2 R ecognise and apply novel methods, approaches and attitudes to teaching The trainee may: 3.2 Learning Opportunities 3.2.1 C omplete a formal course or workshop in clinical teaching 3.2.2 F ormulate a feedback system for personal educational activities 3.2.3 S tudy educational methodology 3.2.4 P articipate in the development of educational changes within the RANZCR 3.2.5 C ontribute to the development of an e-learning module 4 Research Activities The trainee is able to: 4.1 Learning Outcomes 4.1.1 Actively participate in all aspects of clinical trials 4.1.2 E ncourage and mentor other trainees in research 4.1.3 D emonstrate skills required for research, which must include those related to clinical research and may include those related to laboratory research 4.1.4 P ursue accurate data collection of clinical outcomes as a basis for future research initiatives The trainee may: 4.2 Learning Opportunities 4.2.1 Attend a course on trial development e.g. ACCORD workshop Page 150 4.2.2 Attend a course on scientific writing, referencing or searching the medical literature 4.2.3 Visit a radiobiology laboratory 4.2.4 Develop laboratory skills and knowledge 4.2.5 Attend research meetings 4.2.6 Conduct research projects 4.2.7 Write and submit a scientific paper 4.2.8 Present research findings at meetings 4.2.9 Discuss trial participation with patients 4.2.10 Complete clinical research forms and database entry 4.2.11 Undertake training on database design 4.2.12 Join a research organisation e.g. TROG (TransTasman Radiation Oncology Group) 4.2.13 Observe an ethics or scientific committee process/meeting 4.2.14 Contribute to writing an ethics submission for research 4.2.15 Undertake units of relevant postgraduate study relating to research methodology or other research-focussed topic 5 Lifelong Learning The trainee is able to: 5.1 Learning Outcomes 5.1.1 Develop and explore special areas of interest e.g. tumour sites, research, education 5.1.2 Maintain continuing professional development standards 5.1.3 Discuss current literature and practice 5.1.4 Identify gaps in knowledge and take action to redress these The trainee may: 5.2 Learning Opportunities 5.2.1 Read documents associated with the RANZCR Continuing Professional Development Framework 5.2.2 Attend educational and research meetings 5.2.3 Identify and access important oncology journals and other resources for learning 5.2.4 Enrol for study or courses in areas of special interest 5.2.5 Identify and collect sentinel papers 5.2.6 Participate in local and national audit programs © 2012 RANZCR. Radiation Oncology Training Program Curriculum PROFESSIONAL PROFESSIONAL © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 151 Page 152 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Role 7: Professional Role Statement The Radiation Oncologist: • Delivers the highest level of patient care with integrity, honesty and compassion • Exhibits exemplary personal and interpersonal behaviour, and practices ethically • Practices with diligence and active concern for the progress of the profession, while continuing to improve mastery of the discipline 1 Ethical Behaviour The trainee is able to: 1.1 Learning Outcomes 1.1.1 Respect patient and family sensitivities and concerns 1.1.2 Respond appropriately to situations that might compromise the wellbeing of others, including impaired performance of colleagues 1.1.3 Work to promote equitable and compassionate health care 1.1.4 Comply with national standards for research ethics 1.1.5 Respect confidentiality and privacy 1.1.6 Act with sensitivity to patients from differing cultural backgrounds 1.1.7 Respect intellectual property rights and take a strong stand against plagiarism 2 Continuity of Care The trainee is able to: 2.1 Learning Outcomes 2.1.1 Contribute actively to ongoing patient care 2.1.2 Ensure appropriate follow-up of patients The trainee may: 2.2 Learning Opportunities 2.2.1 Make contact with other health professionals e.g. general practitioner, surgeon © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3 Medico-legal Responsibilities The trainee is able to: 3.1 Learning Outcomes 3.1.1 Understand and comply with the legal requirements relating to: − Informed consent, including relevant patient charters such as Patient Code of Rights (NZ) or Australian Commission on Safety and Quality in Health Care (ACSQHC) National Patient Charter of Rights − End of life care − Statutory notification e.g. new cancer, communicable diseases − Impaired colleagues − Radiation safety issues − Employment − Occupational Health and Safety − Privacy and confidentiality The trainee may: 3.2 Learning Opportunities 3.2.1 Obtain informed consent in the clinical setting e.g. radiation therapy treatments and clinical trials 3.2.2 Discuss, document and implement end of life management and advanced health directives 3.2.3 Enter data into patient information systems 3.2.4 Read radiation exposure protocols 3.2.5 Attend radiation safety training courses 3.2.6 Meet with radiation safety personnel 3.2.7 Attend Occupational Health and Safety briefings Page 153 PROFESSIONAL The trainee may: 1.2 Learning Opportunities 1.2.1 Write, or review, an ethics submission 1.2.2 Participate in a human ethics committee 1.2.3 Attend a bioethics course 1.2.4 Read NHMRC standards 1.2.5 Attend cultural awareness training 2.2.2 Attend, and present at, multidisciplinary clinics 2.2.3 Review and manage late side effects 2.2.4 Establish follow-up procedures 4 Colleagues and Patients 6 Risk Management The trainee is able to: 4.1 Learning Outcomes 4.1.1 R ecognise conflicting values and opinions, and develop skills to accommodate these differences 4.1.2 U nderstand and apply principles of duty of care 4.1.3 R espect confidentiality of all communications, both formal and informal, between patients, carers and colleagues 4.1.4Understand and disclose any conflict of interest The trainee is able to: 6.1 Learning Outcomes 6.1.1 Demonstrate good record keeping 6.1.2 Participate in quality assurance programs The trainee may: 4.2 Learning Opportunities 4.2.1 Identify role models 4.2.2 Participate in a mentoring program 4.2.3 Develop stress management strategies 4.2.4 Attend a workshop on stress management 4.2.5 Debrief on complex cases with colleagues 4.2.6 D eclare a conflict of interest at business meetings, trials, or ethics committees The trainee is able to: 7.1 Learning Outcomes 7.1.1 Demonstrate effective time management 7.1.2 Work within their own capacity and have methods of stress management 7.1.3 Follow through on commitments 7.1.4 Set priorities 7.1.5 Adhere to department dress code 7.1.6 Avoid use of substances that impair performance The trainee may: 6.2 Learning Opportunities 6.2.1 Demonstrate open disclosure 6.2.2 Attend morbidity and mortality meetings 6.2.3 Participate in quality assurance studies 7 Personal Management 5 Role Model The trainee is able to: 5.1 Learning Outcomes 5.1.1 Act as a positive role model for students and registrars 5.1.2 D emonstrate to colleagues and patients an awareness and understanding of recent developments related to the profession 5.1.3 Implement RANZCR goals and objectives by active participation in its affairs and by contributing to public debate on issues related to the profession The trainee may: 7.2 Learning Opportunities 7.2.1 Participate in performance management 7.2.2 Display punctuality 7.2.3 Read the code of conduct of the local institution, Area Health Service and the profession 7.2.4 Attend time and behaviour management courses The trainee may: 5.2 Learning Opportunities 5.2.1 N ominate as Trainee Representative on RANZCR Committees 5.2.2 Mentor junior medical staff and students Page 154 © 2012 RANZCR. Radiation Oncology Training Program Curriculum The assessments are described according to the Phase of the program during which they are undertaken, some being specific to one phase or another and several being utilised over the entire program. The requirements and instructions should be sought from the electronic versions of assessment materials found on the College website at http://www.ranzcr.edu.au/radiation-oncology/training-inradiation-oncology . Assessments over the entire program Mini-CEX Mini-CEX is an abbreviation for Mini-Clinical Evaluation Exercise. The mini-CEX is an adaptation of the Clinical Evaluation Exercise previously used by the American Board of Internal Medicine. The mini-CEX’s use as a tool for evaluating medical trainees is now widespread internationally. Use of the mini-CEX involves an assessor (in this case, a supervising Radiation Oncologist) observing a clinical encounter between a trainee and a patient, rating the performance of the trainee on a number of dimensions including interviewing skills, physical examination, professionalism and humanistic qualities, counselling skills, clinical judgment, organisational ability, and with overall score for clinical competence. The rating is performed on a simple 9-point scale. The clinical encounter is designed to take 15 to 20 minutes depending on the complexity of the case. Not all dimensions need to be addressed in each mini-CEX episode, but it is recommended that at least one mini-CEX per year include observation of and feedback on a physical examination of a patient. The assessor provides feedback to the trainee at the end of the encounter. The reliability of the mini-CEX rests on the trainee being observed on several occasions over a period of time by multiple assessors and having serial assessments. This has been demonstrated to be a reliable measure of performance in patient interactions, particularly aptitude in the communicator role. Results are generalisable to the trainee’s everyday clinical practice, provided that sufficient numbers of mini-CEXs are undertaken. Its value as a formative assessment is dependent on the assessor providing prompt feedback to the trainee after the conclusion of the encounter. For this to be optimally effective, assessors require some structured training in provision of trainee feedback. © 2014 RANZCR. Radiation Oncology Training Program Curriculum Trainees are required to complete one mini-CEX approximately every 3 months. Over the course of their training, trainees must achieve a satisfactory result for each individual component of the mini-CEX on at least one, and preferably several, occasions. Additional miniCEXs over the minimum requirement, as desired by the trainee or recommended by the DoT, can be completed. Clinical Supervisor Assessments (CSAs) At the end of each clinical term/rotation or every 6 months (whichever is the more frequent), the trainee will meet with the Clinical Supervisor, who has provided most of the supervision for that term to complete the Clinical Supervisor Assessment. This simple rating form is completed by the Clinical Supervisor and contains a number of items under each of the CanMEDS roles, allowing for elaboration on areas of a trainee’s strengths and weaknesses. This becomes the basis of discussion between the Clinical Supervisor and trainee on their performance and progress during that term/rotation. The record of the CSA must be signed by both the Clinical Supervisor and the trainee, and submitted into the Trainee Information Management System (TIMS), where the CSA can be viewed by their DoT. Director of Training (DOT) Assessments Every 6 months, the trainee should meet with their DoT to complete the DoT assessment. This assessment is predominantly a collation of other assessments undertaken in the previous 6 months and includes a review of these.. The simple rating form is completed by the DoT and contains a number of items under each of the CanMEDS roles, allowing for elaboration on areas of a trainee’s strengths and weaknesses. This form then becomes the basis for a structured discussion, and provides an opportunity for the DoT to give feedback on progress and guidance for further learning. The record of the DoT Assessment must be signed by both the DoT and the trainee, and submitted into TIMS. These interviews may also serve to identify problems with a particular training term or a trainee having other difficulties within training, including failure to adequately progress. Refer to the RANZCR Trainee in Difficulty Policy (Radiation Oncology) for further information as required. Page 155 ASSESSMENTS Description of Assessments Trainee Assessment of Training Site (TATS) Phase 1 only assessments It is important that training sites are monitored in order to demonstrate that aspects of training are delivered safely and effectively. Although this issue of training site performance will be addressed in a variety of ways, one of the most valuable methods is to canvas trainee opinions. Foundation Modules & Clinical Assignments The Trainee Assessment of Training Sites (TATS) is submitted electronically through TIMS. The information is then de-identified, collated, analysed and a report generated. To ensure that trainee feedback on training sites is submitted and is done so in an ongoing manner, records of acknowledgement of submissions are a Training Program requirement. Multi-Source Feedback Assessment (MSF) The use of multi-source feedback tools is common in many areas and sectors of the workplace today. Many medical schools and specialist Colleges around the world use MSF tools to assist in the assessment of, and feedback on, capabilities within the areas of communicator, collaborator, professional and manager. The MSF involves asking a group of 12 -15 people to complete a simple, nine question assessment where the assessor rates the trainee for each dimension on a 9-point scale ranging from unsatisfactory to above expected performance. There is also a section for free-response comments about the trainee’s performance on the job. The assessors are drawn from four groups of co-workers: other senior clinicians, allied health professionals (e.g. radiation therapists, nurses and physicists) administrative or clerical staff, and other trainees. A self-assessment is also conducted. The responses are submitted through TIMS, the results de-identified, collated, analysed, and a report generated by the RANZCR. The report is available to the DoT and the trainee via TIMS, and a discussion of the report is encouraged . The MSF and resultant report provides a valuable opportunity to give ifeedback on a range of professional skills and attributes. Trainees are required to complete one MSF per year, or more as directed by their DoT if reports are considered unsatisfactory. Page 156 The Foundation Modules (designed for the first 6 months or so of training), and the Clinical Assignments (CAs) are aimed at promoting an organised approach to the learning of the Oncology Sciences of Anatomy, Pathology, Radiation and Cancer Biology and Radiation Oncology Physics. It is expected that the Foundation Modules will help teach some underlying principles, after which the CAs will help lead the trainee through the more clinicallylinked and complex sections of the Phase 1 curriculum. Although there is some logical progression through the curriculum topics, it is not intended that the CAs include all content that is required to be learned or that they necessarily deal with content in exactly the same order as the curriculum records it. The CAs are designed to be completed at regular intervals during Phase 1, and are valuable aid in preparation for the Phase 1 Examination. The CAs consist of a series of questions or activities dealing with the Oncology Science subjects. In some instances, the integration of material from various subjects are included to enhance the understanding of links between the material. Trainees are expected to use self-directed learning techniques and resources to assist them in completing the CAs. In addition, tutorials and other clinical teaching activities at the training site will assist the trainee to complete the CAs. Seeking feedback and guidance from DoTs, Clinical Supervisors and other professionals in the training centre is an important part of CA completion. Clinical Supervisors are provided with Feedback Guides to assist them in giving useful feedback to trainees on their CA work. Foundation Modules must be completed and feedback sought and given, but formal submission of these is not required. Trainees are required to complete and formally submit to the College, five (5) CAs in Phase 1. The CAs will be updated and modified over time to enhance their value for learning, but any of the versions of CAs 1 - 5 may be completed, as long as they are substantially different from each other. If trainees do not complete a CA to a satisfactory standard, they will be required to discuss and/ or resubmit the CA (or the sections which were assessed as unsatisfactory) until a satisfactory result is achieved, with the DoT and/or Clinical Supervisor reviewing the CA being the final arbiter. This process need not be very © 2014 RANZCR. Radiation Oncology Training Program Curriculum Phase 1 Practical Oncology Experiences Trainees are expected to meet certain requirements in relation to logged, practical sessions spent with members of other disciplines including other non-Radiation Oncology cancer specialists. These are designed to promote understanding of the full spectrum of cancer management expertise, many aspects of which may not be experienced within the usual day-to-day activities of a Radiation Oncology trainee. In Phase 1, these activities will include a period or sessions attached to the radiation therapists and physicists in planning and treatment, and to radiologists for learning of anatomy. Some reflection on the part of the trainee in relation to learning objectives met by these practical experiences will form part of the assessment. Suggested goals for these experiences and some questions trainees may find helpful to ask (in addition to the related Learning Objectives in the curriculum) are provided in the Assessment Instructions located on the website at http://www.ranzcr. edu.au/training/resources/current-trainees/resourcesfor-radiation-oncology-trainees/assessments-radiationoncology. Phase 1 Examination The Phase 1 Examination will consist of two written papers, examining the Oncology Science subjects. Questions will test knowledge in these subjects but also synthesis and integration of this knowledge. The subjects will be weighted as follows: Anatomy, Radiation Physics and Cancer and Radiation Biology 30% each and Pathology 10%. The results of the Phase 1 Examination will be included in the trainees profile in TIMS. Trainees are required to pass this examination before progressing to Phase 2. Phase 2 only assessments Case Reports The Case Reports are intended to act as a Log Book of clinical activity, and provide a directly relevant, systematic record of patient cases and management, particularly © 2014 RANZCR. Radiation Oncology Training Program Curriculum in the area of radiation therapy planning and treatment and also for specialized radiation and other oncology techniques and experiences. Full details, requirements, templates, instructions and additional Learning Outcomes are provided in the Assessment Instructions located on the College website at -http://www.ranzcr.edu.au/training/ resources/current-trainees/resources-for-radiationoncology-trainees/assessments-radiation-oncology Trainees are required to complete a minimum of 30 case reports prior to sitting their Phase 2 Examination. These will contain elements relating to clinical presentation, decision-making and radiation technique. Attempts should be made to spread the reports across the MES in the “major focus” and “lesser focus” topics. There is no maximum number for Case Reports to be completed by the trainee. It is anticipated that trainees may choose to complete many more brief reports on interesting or common scenarios to aid and document their learning, especially in relation to technical treatment issues, in the same way a case Log Book might be used. Furthermore, it will likely be helpful for trainees to start documenting specific cases early in the course of their training and, depending on progress, undertake some Case Reports (a maximum of 5 of the 30 if only 30 overall completed) in the latter part of Phase 1. Statistical Methods, evidence Appraisal and Research for Trainees (SMART) Program 1. Research Requirement The research requirement aims to foster an interest in research, establish an understanding of research methodology, ensure participation in research as an integral component of Radiation Oncology training and subsequent specialist practice, and encourage trainees to contribute to the oncology literature. Trainees are required to undertake a piece of original research and to prepare a manuscript for submission. The manuscript must be submitted to JMIRO or another peer-reviewed journal. Acceptance to the peer-review process will serve to satisfy the requirement. Trainees will be required to provide proof of acceptance to peer review before applying to sit the Phase 2 examinations. Page 157 ASSESSMENTS formal if the trainee is felt to have achieved most of the important outcomes. 2. SMART Points Accrual To satisfy the accrual of SMART points assessment requirement, trainees will be required to attain a minimum of 20 SMART points by taking part in a selection of activities which provide learning opportunities to address learning outcomes within the Scholar, Collaborator & Communicator roles of the curriculum. Trainees can begin collecting points as soon as they enter the training program. 20 SMART points will need to be collected and evidence of submission (in the form of a brief form and/or certificate of completion) must be received by the College to satisfy the requirement and allow application to sit the Phase 2 examination. Ten (10) points can be earned by attendance at one (of two) of the annual joint TROG/FRO SMART workshops to be run in conjunction with the TROG ASM each year. Attaining 10 points through this activity is strongly recommended, but not mandatory. Phase 2 Examination The Phase 2 Examination will comprise written and oral (viva) components covering all aspects of Pathology, Clinical Oncology and Radiation Therapy, including diagnosis, management and technical aspects of planning and delivery of radiation therapy. There are 4 written papers in the above subjects. The viva examinations include a radiation therapy Planning Examination (using photographic prompts), 8 clinical ‘short’ cases (some with actual patients and some with clinical prompts), and a Pathology viva. One of the clinical ‘short’ cases will assess physical examination skills alone. Full eligibility criteria for sitting the Phase 2 Examination are published on the College website at http://www.ranzcr.edu.au/radiationoncology/ traininginradiationoncology Trainees are required to pass the Phase 2 Examination before being eligible to proceed to Fellowship. The requirements of the Phase 2 examination are detailed further on the RANZCR website at http://www.ranzcr.edu. au/radiation-oncology/training-in-radiation-oncology. Page 158 © 2014 RANZCR. Radiation Oncology Training Program Curriculum Assessing the CanMEDS Roles The following table details how the variety of assessment tools used within the training program may relate to the spectrum of the CanMEDS roles. CanMEDS Roles 3 3 3 DOT Assessment 3 3 3 Practical Oncology Experience 3 3 3 Clinical Supervisor Assessment 3 3 3 MSF 3 Professional Mini-CEX Scholar 3 Health Advocate Communicator 3 Manager Medical Expert Clinical Assignments Collaborator Evidence 3 3 3 3 3 3 3 3 3 3 3 3 3 Examinations 3 3 Case Reports 3 3 3 Research Requirement 3 3 SMART points accrual 3 3 © 2012 RANZCR. Radiation Oncology Training Program Curriculum 3 3 3 3 3 3 3 3 3 3 3 Page 159 ASSESSMENTS 3 TATTs Page 160 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Glossary AIDS Acquired Immunodeficiency Syndrome AJCC American Joint Cancer Collaborative ALARA As Low As Reasonably Achievable ALL Acute Lymphoblastic Leukaemia AN Acoustic Neuroma AVMs Cerebral Arteriovenous Malformations BRCA Breast Cancer (Genes 1 And 2) CanMEDS Canadian Medical Education Directives For Specialists CHART Continuous Hyperfractionated Accelerated Radiation Therapy CIS Carcinoma-In-Situ CNS Central Nervous System COG Children’s Oncology Group CSF Cerebrospinal Fluid CSI Craniospinal Irradiation CT Computed Tomography CTV Clinical Target Volume D A Detailed level of knowledge, and ability to apply this knowledge in clinical settings, is required DNA Deoxyribonucleic Acid DoT Director of Training EGFR Epithelial Growth Factor Receptor ERCP Endoscopic Retrograde Cholangiopancreatogram EUA Examination Under Anaethesia FIGO International Federation of Gynaecology And Obstetrics G A more General level of knowledge, and minimal application of this knowledge, is required GIST Gastrointestinal Stromal Tumours GTV Gross Tumour Volume HBO Heterotopic Bone Ossification HCC Hepatocellular Carcinoma HCG Human Coreogonadotrophin HDR High Dose-Rate HIV Human Immunodeficiency Virus HL Hodgkin Lymphoma HPV Human Papilloma Virus I Ability to perform the specified activity essentially Independently IAEA International Atomic Energy Agency ICRP International Commission on Radiological Protection ICRU International Commission on Radiation Units and Measurements IMRT Intensity-Modulated Radiation Therapy © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 161 ITV Integral Tumour Volume kV Kilovoltage LDR Low Dose-Rate LET Linear Energy Transfer MAC Modified Astler Coller MALT Mucosa-Associated Lymphoid Tissue MDT Multidisciplinary Team MEN Multiple Endocrine Neoplasia MES Medical Expert Supplement(S) MIBG Meta Iodobenzylguanidine Mini-CEX Mini-Clinical Evaluation Exercise MRA Magnetic Resonance Angiography MRC Medical Research Council MRI Magnetic Resonance Imaging MRS Magnetic Resonance Spectroscopy MSCC Malignant Spinal Cord Compression MSF Multi-Source Feedback MV Megavoltage NHL Non-Hodgkin’s Lymphoma NHMRC National Health And Medical Research Council NSCLC Non-Small Cell Lung Cancer NSGCT Non-Seminomatous Germ Cell Tumours NZ New Zealand PBCL Primary B-Cell Lymphoma PCR Polymerase Chain Reaction PDR Pulsed Dose Rate PET Positron Emission Tomography PNET Primitive Neuroectodermal Tumour PSA Prostate-Specific Antigen PTCL Primary T-Cell Lymphoma PTV Planning Target Volume QoL Quality of Life RANZCR Royal Australian and New Zealand College of Radiologists RB Retinoblastoma RFA Radiofrequency Ablation RMS Rhabdomyosarcoma RNA Ribonucleic Acid ROCKSS Radiation Oncology Central Knowledge and Skills Summary RT-PCR Reverse Transcriptase – Polymerase Chain Reaction Page 162 © 2012 RANZCR. Radiation Oncology Training Program Curriculum S Ability to perform the specified activity under Supervision SCC Squamous Cell Carcinoma SCLC Small Cell Lung Cancer SF 36/12 Short Form Health Survey Questionnaire (36/12 Items) SMART Statistical Methods, evidence Appraisal and Research for Trainees SIOP International Society of Paediatric Oncology SSD Source-Surface Distance SVCO Superior Vena Caval Obstruction TAHBSO Total Abdominal Hysterectomy and Bilateral Salpingo-Oophorectomy TATTs Trainee Assessments of Training Terms TBI Total Body Irradiation TCC Transitional Cell Carcinoma TNM Tnm (Tumour, Nodes and Metastases) Classification of Malignant Tumours TROG Trans-Tasman Radiation Oncology Group TURB Trans-Urethral Resection of The Bladder TURBT Trans-Urethral Resection of Bladder Tumour US Ultrasound UV Ultraviolet vs. Versus WHO World Health Organisation © 2012 RANZCR. Radiation Oncology Training Program Curriculum Page 163 Page 164 © 2012 RANZCR. Radiation Oncology Training Program Curriculum ALPHABETICAL INDEX OF MEDICAL EXPERT SUPPLEMENTS Acoustic Neuroma 94 Adrenal Tumours 114 Adult Gliomas 88 Aggressive Fibromatosis 106 Anal Cancer 81 Biliary Tract and Gall Bladder Cancers 82 Bladder Cancer 74 Bone Metastases 105 Breast Cancer 44 Carcinoid Tumour 84 Cerebral Arteriovenous Malformations 95 Cerebral Metastases 91 Cervical Cancer 68 Colon Cancer 85 Gastric Carcinoma 78 Gastrointestinal Stromal Tumours 84 Gestational Trophoblastic Disease 72 Head and Neck Cancers 53 Hepatocellular Carcinoma 83 Hodgkin Lymphoma 98 Kaposi’s Sarcoma 59 Kidney and Ureter Cancer 75 Leukaemia100 Liver Metastases 86 Malignant Spinal Cord Compression 92 Medulloblastoma and Primitive Neuroectodermal Tumours 90 Melanoma59 Meningioma89 Mesothelioma50 Metastases at Sites Not Otherwise Specified 118 Metastatic Carcinoma of Unknown Primary Site 118 Multiple Myeloma 100 Non Melanomatous Skin Cancer 58 Non-Hodgkin Lymphoma 99 Non-Malignant Diseases treated with Radiation Therapy 122 Non-Seminomatous Germ Cell Tumours 64 Non-Small Cell Lung Cancer 48 Oesophageal Cancer 78 Other CNS tumours: ependymoma, pineal and germ cell tumours 93 Ovarian Cancer 69 Paediatric Cancers 110 Pancreatic Cancer 79 Penile Cancer 65 © 2012 RANZCR. Radiation Oncology Training Program Curriculum Pituitary Tumours Primary Tumours of the Bone Prostate Cancer Quality of Life Rectal Cancer Seminoma of the Testis Small Cell Lung Cancer Soft Tissue Sarcoma Superior Vena Caval Obstruction Symptom Control Thyroid Cancer Tumours of the Mediastinum Uterine Cancer Vaginal Cancer Vulval Cancer 89 106 62 125 80 63 49 104 50 124 114 51 69 71 70 Page 165