Editorial Annual Progress Report and Our Thanks to Referees Dear Colleagues: This is our seventh annual progress report to you. Once again, we want to extend to each of you our deep gratitude for your words of encouragement and support over these years. It is difficult to realize that these 7 years have flown by so rapidly. As we enter our final year of our editorial tenureship, we are grateful for the opportunity we have been given to bring to you what we truly believe is the best of the world’s research achievements. With respect to our most recent publication statistics, we are proud and pleased to tell you that the impact factor of our journal remains the highest of all hypertension journals, 4.93 for 1999. The number of manuscripts submitted to us continues to increase. Last year, 1,269 manuscripts were submitted to the journal; and, as of the end of October 2000, we have received 1,071 papers and we anticipate receiving about 1,300 submissions by year’s end. Bear in mind that this does not include the papers submitted for the Inter-American Society of Hypertension meeting, because these scientific sessions are held biennially. We continue to maintain a very speedy initial review time of 4.0 weeks from submission to first decision and 13.3 weeks from submission to final acceptance. As you know, the first figure is probably the more pertinent datum for an author to assess the promptness and efficiency of a journal’s review process. The latter figure reflects many other factors including the speediness of authors to respond to the reviewers’ comments and suggestions (including the performance of additional experiments). Special note should be made that over these past 7 years, we have increased the number of clinically oriented research papers published in Hypertension, and, at present, they comprise over one half of the manuscripts published. They represent the very best and cutting-edge work in clinical investigation and, clearly, are on par with those other papers published in our journal from the various fundamental laboratory sciences. We are also pleased that over one half of the papers submitted to Hypertension emanate from the best laboratories of countries other than the United States. For your interest, the top 5 countries submitting papers to Hypertension in this past year originate from Japan, Italy, Germany, United Kingdom, and France (in that order). Our foreign submissions have continued to increase, and they presently exceed the number of papers submitted from the United States. Thus, as of the end of October 2000, there were 711 foreign submissions as compared to 360 from the United States. We will soon implement publishing a condensed print version of the Materials and Methods section. A more detailed (but not copyedited) Materials and Methods section will be published online each month as a data supplement. This will be done in an effort to publish more manuscripts as well as for us to continue to shorten the time from acceptance to publication. Before closing, we wish to reiterate a personal comment that must be obvious to each of you. Over these years you have commented to us personally and in writing about your satisfaction with the manner in which you have related with our editorial office staff. So, once again, we want to express our total delight and deep satisfaction with our outstanding staff. We are truly proud of their commitment to the journal and to all of us who have had the pleasure of working with them. Debby Smith and Irene Hebert have done a tremendous job in relating to our authors, publisher, and the American Heart Association staff. Lisa Pineda, who recently joined us, supports their efforts. And all of us want to express our appreciation to the publication staff of Lippincott Williams & Wilkins. Working with them each day continues to be an ongoing pleasure. I also want to express my everlasting fondness, respect, and appreciation of Richard N. Ré and L. Gabriel Navar. They are superb colleagues, broadly knowledgeable, and totally committed to our journal. Finally, as we always do each year, we are pleased to credit the unselfish time provided to the journal and its readers by more than 700 reviewers and the hardworking editorial board members for their outstanding review of submitted manuscripts. These peer reviewers from all over the world underscores our point that Hypertension, as a journal, is appreciated worldwide. You may be interested that over 50 of these colleagues and friends of all of us have reviewed over 10 papers this past year. Clearly, without their interest, generosity of time and effort, and their tremendous commitment, our editorial responsibilities would not have been as rewarding. (Hypertension. 2001;37:1-5.) © 2001 American Heart Association, Inc. Hypertension is available at http://www.hypertensionaha.org 1 2 Hypertension January 2001 Aalkjaer, Christian Abboud, Hanna E. Abe, Jun-ichi Abramson, Stephen Adair, Thomas H. Agabiti-Rosei, Enrico Agarwal, Arun K. Alam, Jawed Alderman, Michael H. Alexander, J. Steve Alexander, R. Wayne Alhenc-Gelas, Francois Allen, Andrew M. Allen, Michael T. Altura, Burton M. Amerena, John Amiri, Farhad Anderson, David Anderson, Erling A. Anderson, Sharon Anderson, Warwick P. Andriantsitohaina, Romaroson Antonios, Tarek Anversa, Piero Appel, Lawrence J. Ardaillou, Raymond Ardell, Jeff Arendshorst, William J. August, Phyllis Averill, David B. Aviv, Abraham Avolio, Alberto Azizi, Michel Bachmann, Sebastian Bachvarov, Dimcho Bader, Michael Bagrov, Alexei Bairey-Merz, Noel C. Baker, Kenneth M. Bakris, George L. Bank, Norman Barajas, Luciano Barker, D. J. P. Barman, Susan M. Barnard, R. James Baron, Alain D. Barrett, Jack D. Barton, Matthias Batlle, Daniel C. Batuman, Vecihi Baumbach, Gary L. Baxter, G. F. Baylis, Christine Becker, Lewis Beevers, D. Gareth Beierwaltes, William H. Beilin, Lawrence J. Bell, David Benetos, Athanase Bennett, Max R. Berecek, Kathleen H. Berk, Bradford C. Bernard, Catherine Bernstein, Kenneth E. Berry, Colin Best, Patricia Biaggioni, Italo Bianchi, Giuseppe Bidani, Anil K. Bie, Peter Bing, Oscar H. Bing, Richard Binkley, Phillip F. Birkenhager, W. H. Bishop, Sanford P. Bishop, Vernon S. Black, Henry R. Blaine, Edward H. Blatteis, Clark M. Blaustein, Mordecai P. Bobik, Alex Boerwinkle, Eric Boger, Rainer H. Bohlen, H. Glenn Bohm, Michael Bohr, David F. Bonsignore, Maria R. Booz, George W. Boulanger, Chantal Bradford, W. David Brands, Michael W. Braiser, Allan Bravo, Emmanuel L. Bray, George A. Brayden, Joseph E. Brecher, Peter Brenner, Barry M. Briggs, Clark A. Brook, Rob Brooks, David Brooks, Robert Brooks, Virginia L. Brosius, Frank Brosnihan, K. Bridget Brown, Morris J. Brown, Nancy J. Brownley, Kimberly Brunner, Hans R. Buckalew, Vardaman M., Jr. Bukoski, Richard D. Bulpitt, Christopher J. Burnier, Michel Burt, Vicki L. Busse, Rudi F. Calhoun, David Cambien, Francois Campbell, Duncan J. Campbell, William B. Campese, Vito M. Cannon, Paul J. Capdevila, Jorge H. Carabello, Blase A. Carey, Robert M. Carmines, Pamela K. Carretero, Oscar A. Casadei, Barbara Catanzaro, Daniel Catt, Kevin J. Caulfield, Mark Cerutti, Catherine Challis, John R. G. Chambers, Richard Chao, Julie Chapleau, Mark W. Chappell, Mark C. Charpie, John Chaudhuri, Gautam Chen, Alex Cheung, Donald Cheung, Oliver Chiabrando, Chiara Chien, Kenneth R. Chien, Shu Chilian, William M. Chrysant, Steven Chung, Oliver Cirillo, Massimo Clement, Denis L. Cleroux, Jean Clozel, Jean-Paul Clozel, Martine Cody, Robert J. Coetzee, William Coffman, Jay D. Coffman, Thomas Cohen, Richard A. Cohn, Jay N. Colucci, Wilson Connell, John M. C. Cook, Julie Cooper, Richard S. Corvol, Pierre Cowley, Allen W., Jr. Cox, Robert H. Crandall, David Creager, Mark A. Crow, Michael Crystal, Ronald G. Cunningham, Thomas Cutler, Jeffrey Dampney, Roger Daniels, Stephen R. Danser, A. H. Jan Dart, Richard A. Das, Dipak K. Davidge, Sandra Davis, Michael Davison, Cathy A. Davisson, Robin de Bold, Adolfo J. de Champlain, Jacques De Jong, Paul E. de Leeuw, Peter W. de Lemos, James de Mello, Walmor De Simone, Giovanni De Stefano, Anita de Wardener, Hugh E. Deddish, Peter A. Delafontaine, Patrick Deng, Alan Y. Deschepper, Christian F. Devereux, Richard B. Devlin, Alison M. Dhalla, Naranjan S. DiBona, Gerald F. Dietz, Nancy Diez, Javier Dimsdale, Joel Distler, Armin Diz, Debra I. Dobrin, Philip B. Dominiczak, Anna F. Dorrance, Anne Dostal, David E. Douglas, Janice G. Drexler, Helmut Dries, Daniel Dubey, Raghvendra K. Ducimetiere, Prof. Dunbar, Joseph Dunn, Francis G. Dunn, Michael J. d’Uscio, Livius Dzielak, David J. Eckberg, Dwain L. Egan, Brent Egashira, Kensuke Ehmke, Heimo Ehsani, Ali A. El-Dahr, Samir S. Elam, Mikael Elghozi, Jean-Luc Elijovich, Fernando Elliott, William J. Ely, Daniel England, Sarah Epstein, Murray Erdos, Ervin G. Erne, Paul Ernsberger, Paul Esler, Murray D. Espiner, Eric A. Eto, Tanenao Faber, James E. Fabsitz, R. Fagard, Robert Falkner, Bonita Feener, Edward Feldman, Ross D. Felley-Bosco, Emanuela Ferguson, Alastair V. Ferrannini, Ele Ferrari, Alberto Ferrario, Carlos M. Feuerstein, Gioria Z. Fingerle, Jurgen Fink, Gregory D. Fitzgibbon, Wayne Flack, John M. Fleg, Jerome L. Fletcher, Eugene R. Floras, John S. Fogo, Agnes B. Frohlich et al Foletou, Michel Folts, John D. Ford, Charles Fouad-Tarazi, Fetnat Francis, Gary S. Franco-Saenz, Roberto Franklin, Stanley Fray, John C. S. Freeman, Ernest Freeman, Ronald H. French, Brent Frishman, William H. Froelich, Juergen C. Froelicher, Victor F. Fujishima, Masatoshi Fujita, Masatoshi Fujita, Toshiro Funder, John W. Furlan, Raffaello Gaasch, William H. Gabbiani, Giulio Galletti, Ferruccio Ganten, Detlev Gardiner, Sheila M. Gardner, David G. Gardner, Jeffrey P. Garvin, Jeffrey L. Gavras, Haralambos P. Gavras, Irene Gelband, Craig Gerdes, A. Martin Gerthoffer, William T. Ghione, Sergio Gifford, Ray W., Jr. Giles, Thomas D. Giles, Wayne Gillum, Richard F. Glantz, Stanton A. Gnasso, Agostino Godfraind, Theophile Godfraind, Theophile Gohlke, Peter Goldstein, David S. Gomez-Sanchez, Celso E. Gomez-Sanchez, Elise P. Gonick, Harvey Goodfriend, Theodore L. Gopalakrishnan, Venkat Goto, Atsuo Goto, Katsutoshi Graham, Robert Grammas, Paula Granger, D. Neil Granger, Joey P. Grassi, Guido Greenland, Philip Griendling, Kathy Griffin, Karen Ann Grimm, Richard H., Jr Gross, Kenneth W. Grover, A. K. Grundy, Scott Gyurko, Robert Haddy, Francis J. Hainesworth, Roger Hall, Ian Hall, John E. Hall, W. Dallas Hallenbeck, John M. Hamet, Pavel Hamilton, Carlene A. Hamlyn, John M. Hamm, L. Lee Hansen-Smith, Fay Harrap, Stephen B. Harris, Raymond C. Harrison, David G. Harrison-Bernard, Lisa M. Harsdorf, Ruediger V. Haselton, James Hassid, Aviv I. Haus, Erhard Haynes, William Hayoz, Daniel Haywood, Joseph R. Hazen, Stanley He, Jiang Heagerty, Anthony M. Hecker, Markus Heerden, J. Van Heesch, Cheryl M. Heistad, Donald D. Heller, Lois Herrera, Victoria L. M. Hershey, Linda Hinderliter, Alan L. Hinojosa-Laborde, Carmen Hintze, Thomas H. Hirata, Yasunobu Hirooka, Yoshitaka Horiuchi, Masatsugu Horton, Jureta W. Hostetter, Thomas H. Houghton, Jan L. House, James S. Hsueh, Willa A. Hubner, N. Hunt, Steven C. Hurst, J. Willis Husain, Ahsan Huxley, Virginia H. Hyman, Albert L. Ichikawa, Iekuni Iellamo, Ferdinando Imai, Yutaka Imig, John D. Inagami, Tadashi Ingelfinger, Julie R. Inscho, Edward W. Insel, Paul A. Ishii, Masao Ishimitsu, Toshihiko Ito, Sadayoshi Izumo, Seigo Izzo, Joseph L., Jr. Jackson, Cynthia Jackson, Edwin K. Jackson, Simon Jamerson, Kenneth A. James, Edgar Janicki, Joseph S. Jeunemaitre, Xavier Johns, Douglas G. Johns, Edward J. Johnson, Alan Kim Johnson, Richard J. Johnson, Robert A. Johnston, Colin I. Joles, Jaap A. Jones, Daniel W. Joossens, Jozef V. Jose, Pedro A. Julius, Stevo Kadowitz, Philip J. Kaissling, Brigitte Kanagy, Nancy Kannel, William B. Kaplan, Norman M. Kaplan, Robert C. Karemaker, John M. Kass, David A. Kastin, Abba J. Katusic, Zvonimir Katz, Arnold M. Kawachi, Ichiro Kawano, Yuhei Kem, David C. Kennedy, Richard H. Kern, Philip A. Kesteloot, Hugo Khalil, Raouf A. Kim, Shokei Kirchner, Kent A. Kitamura, Kazuo Klarr, Susan A. Klatsky, Arthur L. Klein, Robert M. Klett, Christopher Kline, Robert L. Klinger, James R. Klungel, Olaf H. Knot, Harm J. Kobayoshi, Naohiko Kochar, Mahendr S. Kohan, Donald E. Koller, Akos Kontos, Hermes A. Kopin, Irwin J. Kopp, Ulla C. Koren, Michael J. Korner, Paul I. Kost, Curtis K., Jr. Kotchen, Jane Morley Kotchen, Theodore A. Krakoff, Lawrence R. Krieger, Eduardo M. Krousel-Wood, M. A. Krushkal, Julia Kuller, Lewis H. Kurtz, Armin Kurtz, Theodore W. LaPointe, Margot C. Annual Progress Report 3 LaRosa, John C. Lackland, Daniel Lahera, Vicente Lalouel, Jean-Marc Lang, C. C. Lauer, Ronald M. Laurent, Stephane Laurindo, Francisco R. M. Lautt, Wayne Lavrovsky, Yan Lawrence, Andrew J. Lee, Amanda Lee, Richard T. Lee, Wai K. Leeb-Lundberg, L. M. Fredrick Leenen, Frans H. H. Lentz, Steven R. Lerman, Amir Levenson, Jaime Lever, Anthony F. Levy, Daniel Levy, Howard P. Libby, Peter Linas, Stuart Lindheimer, Marshall D. Linz, Wolfgang Lip, Gregory Lip, Gyh Liu, Peter Lockette, Warren E. Loeffler, Bernd-M. Lohmeier, Thomas E. Lokhandwala, Mustafa F. Lombard, Julian H. London, Gerard M. Loscalzo, Joseph Loutzenhiser, Rodger Lovallo, William R. Lucchesi, Pamela Luft, Friedrich C. Luft2 LuftB, Friedrich C. Lumbers, Eugenie Luscher, Thomas F. Lyall, Fiona Lynch, Sean MacGregor, Graham A. Macfarlane, Peter W. Madeddu, Paolo Magness, Ronald R. Majid, Dewan Malik, Kafait U. Malliani, Alberto Mancia, Giuseppe Manger, William M. Mangili, Ruggero Mangili, Ruggero Manning, P. Davis, Jr. Mansoor, George Marceau, Francois Margolius, Harry S. Mark, Allyn L. Marrero, Mario Marsh, James D. 4 Hypertension Massie, Barry M. Materson, Barry J. Matsubara, Hiroaki Matsuoka, Hiroaki Mattson, David Mayet, Jamil McCarron, David A. McGiff, John C. McNamara, Dennis McNeill, John H. Mehta, Jay L. Meier, Christoph R. Meininger, Gerald A. Melby, James C. Mendelsohn, F. A. O. Merz, C. Noel Bairey Messerli, Franz H. Michel, Martin C. Middlekauff, Holly Miller, Allison Miller, Virginia M. Mills, Paul Mitchell, Gary F. Mitchell, Kenneth D. Miyazaki, Mizuo Mogensen, Carl Erik Montastruc, Jean-Louis Moore, Leon C. Moreau, Pierre Morgan, Trefor O. Morishita, Ryuichi Morkin, Eugene Morris, Brian J. Morris, David J. Morris, Mariana Morrison, Shaun Mortara, Andrea Moser, Marvin Moser, Ulrich Mugge, Andreas Muiesan, M. Lorenza Mulatero, Paolo Mullins, Linda Mulroney, Susan Mulrow, Patrick J. Multhoff, Gabrielle Mulvany, Michael J. Munzel, Thomas Murakami, Hiroshi Nadler, Jerry L. Naeije, Robert Nakamura, Yasuyuki Nakao, Kazuwa Nakazawa, Hiroe Naraghi, Ramin Nath, Karl Navar, L. Gabriel Nazzaro, Pietro Nemenoff, Raphael New, Maria I. Newton, Josh Nicholls, M. Gary Nishikimi, Toshio Nishiyama, Akira January 2001 Nitenberg, Alain Noll, Georg Nussberger, Juerg O’Brien, Eoin O’Connor, Daniel T. O’Rourke, Michael F. Ogihara, Toshio Ohanian, J. Ojo, A. Olsen, Jorgen H. Olsson, Ray A. Omae, Teruo Ono, Hidehiko Oparil, Suzanne Ordovas, Jose M. Orlov, Sergei Overton, J. Michael Owens, Gary K. Ozo, A. Pagano, Patrick J. Palatini, Paolo Pandey, Kallash N. Panza, Julio A. Paoletti, Rodolfo Paolisso, Giuseppe Parati, Gianfranco Parving, Hans H. Paul, Martin Paulus, W. J. Pedrinelli, Roberto Pepine, Carl J. Perez-Stable, Eliseo J. Perloff, Dorothee L. Perry, Colin Perry, Jr., H. Mitchell Persson, Pontus B. Pfaffendorf, Martin Pfeffer, Marc A. Phillips, D. Phillips, M. Ian Phillips, Robert Pickering, Thomas G. Pieper, Galen M. Pitt, Bertram Ploth, David W. Plutzky, Jorge Pohl, Ulrich Pollitzer, William S. Pollock, David M. Pollock, Jennifer S. Prasad, Ananda S. Pratt, J. Howard Prewitt, Russell L. Printz, Morton P. Pritchard, Kirkwood A., Jr. Puddey, Ian B. Purdy, Ralph E. Quilley, John Quyyumi, Arshed A. Rabelink, Ton Radomski, Marek W. Raffenstin, Bernadette Raij, Leopoldo Rajagopalan, Sridharan Rakugi, Hiromi Ram, C. Venkata S. Rao, D. C. Rapp, John P. Rappaport, Lydie Re, Richard N. Reaven, Gerald M. Reckelhoff, Jane F. Reddi, Alluru S. Reddix, Rhoda Redfield, Margaret M. Reeves, John Regoli, Domenico C. Reid, Ian A. Reid, John L. Reinhart, Glenn A. Reisin, Efrain Remuzzi, G. Resnick, Lawrence M. Resta, Tom Reudelhuber, Timothy L. Richardson, David W. Ritz, Eberhard Roberts, James M. Robertson, David Rocchini, Albert P. Rodicio, Jose L. Rojagopalan, Sonjay Roman, Mary J. Roman, Richard J. Romero, Juan C. Rosendorff, Clive Rosenman, Ray H. Rosenthal, Julian Rosenthal, Talma Rossi, Gian Paolo Rotimi, Charles Rowland, Neil Rubinstein, Israel Ruilope, Luis M. Rump, L. C. Rusch, Nancy Saade, George R. Saavedra, Juan M. Sachinidis, Agapios Sacks, Frank Safar, Michel Saito, Yasushi Salazar, F. Javier Salgado, Helio C. Salonen, Jukka T. Salvetti, Antonio Samani, Nilesh J. Sanders, Paul W. Sapru, Hreday N. Sarkar, Rajabrata Saruta, Takao Sasayama, Shigetake Sassard, Jean Sato, Akio Saunders, Elijah Sawicki, Grzegorz Schafer, James A. Schatz, Irwin Schieken, Richard M. Schiffrin, Ernesto L. Schillaci, Giuseppe Schmid-Schonbein, Geert W. Schmidt, Harald Schnackenberg, Christine G. Schnermann, Jurgen B. Schobel, Hans Paul Scholkens, Bernward A. Schor, Nestor Schork, Nicholas J. Schrier, Robert Schunkert, Heribert Schwartz, Arnold Schwartz, Gary L. Scicli, A. Guillermo Seals, Douglas R. Seidman, Daniel Sen, Subha Sever, Peter S. Shade, Robert E. Shapiro, David Sharma, Arya M. Sharma, P. Sharp, Matthew F. Shimada, Kazuyuki Shroff, Sanjeev G. Siffert, Winfried Sigmund, Curt D. Silverberg, Donald Simon, Geza Singh, Krishna Siragy, Helmy M. Skrabal, Falko Sleight, Peter Smilde, Tineke J. Smulyan, Harold Solomon, Caren Solomon, Scott D. Somers, Virend K. Soubrier, Florent Sowers, James R. Speth, Robert Spodick, David H. St. Lezin, Elizabeth Staessen, Jan Stallone, John N. Steinberg, Helmut O. Stekiel, William J. Stern, David Stevens, Victor Stevenson, Lynn Warner Strauer, Bodo-Eckehard Strazzullo, Pasquale Sturek, Michael Sudhir, Krishna Sumners, Colin Sumpio, Bauer E. Sun, Yao Susic, Dinko Suzuki, Hiromichi Swynghedauw, Bernard Tackett, Randall L. Taddei, Stefano Frohlich et al Takekoshi, Kazuhiro Takeshita, Akira Takishita, Shuichi Tallant, Elisabeth Ann Tallant, Mario Talman, William T. Tamaki, Toshiaki Tanaka, Hirofumi Taylor, Addison A. Taylor, W. Robert Tedgui, Alain Tejwani, Gopi Terada, Naohiro Textor, Stephen Thibault, Gaetan Thiemermann, Chris Thomas, Walter G. Thornburg, Kent L. Thrasher, Terry N. Timmermans, Pieter BMWM Tiret, Laurence Toney, Glenn Touyz, Rhian M. Trimarco, Bruno Troughton, Richard Tuck, Michael Turk, James R. Uhal, Bruce Umemura, Satoshi Unger, Thomas Vallance, Patrick van Berkel, Theo van Hinsbergh, Victor W.M. VanZwieten, Pieter A. Vanhoutte, Paul M. Varagic, Jasmina Vari, Richard C. Varma, Daya R. Vaughan, Douglas E. Vaughan, E. Darracott Vaziri, N. D. Ventura, Hector O. Verdecchia, Paolo Vetter, Hans Vetter, Wilhelm Victor, Ronald G. Villarreal, Francisco J. Vio, Carlos P. von Harsdorf, Rudiger Waeber, Bernard Wall, Susan Wang, Donna H. Annual Progress Report Ward, Ken Warnock, David G. Watson, Karol Watts, Stephanie Webb, David J. Webb, R. Clinton Weber, David Weber, Karl T. Weber, Michael A. Weder, Alan B. Wei, Kevin Weinberger, Myron H. Weiner, Norman Weir, Matthew R. Welch, William J. Wesson, Donald E. Westerhof, Nicolaas Wetmur, James White, William B. Whitworth, Judith A. Wilcox, Christopher S. Wilson, Britt Wilson, Loretta Wingard, Chris Wirth, Klaus J. Witztum, Joseph 5 Wong, Pancras C. Wood, Alastair J. J. Wood, Stephen C. Wright, John W. Wyss, J. Michael Xiao, Rui-Ping Yagi, Shigeru Yamori, Yukio Yanagisawa, Masashi Yang, Baichun Yang, Xiao-Ping Yazaki, Yoshio Yokoyama, Mitchel M. Young, David B. Young, James B. Young, William Yuan, Jason X. J. Zambraski, Edward Zatz, Roberto Zhou, Xiaoyan Zhou, Xin Jin Zidek, Walter Zimmerman, Ben G. Zou, Al-Ping Zuccarello, Mario Zukowska-Grojet, Zofia Zusman, Randall M. Edward D. Frohlich, MD Editor-in-Chief L. Gabriel Navar, PhD Associate Editor Richard N. Ré, MD Associate Editor ***IMPORTANT MESSAGE FOR AUTHORS*** The editors have made several important new innovative changes in the Instructions to Authors in this issue concerning the Methods section of new manuscripts as well as the presently available electronic submission.