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14 AUGUST 2014 x VOLUME 124, NUMBER 7
CONTENTS
COVER FIGURE
Scanning electron micrograph of chronic lymphocytic leukemia B cell atop
nanowires taken 24 h after plating, imaged with a Zeiss Ultra55 microscope,
magnification 313710. See the article by Wang et al on page 1089.
INSIDE BLOOD COMMENTARIES
985
Novel insights related to CF neutrophils
Silvia M. Uriarte
986
Oral therapy for multiple myeloma: ixazomib arriving soon
Philippe Moreau
987
First do no harm: infectious deaths in pediatric ALL
Karen R. Rabin
989
Old and new news in CLL: “It’s the pathway, stupid!”
Alexander Egle
991
A common progenitor cell in LCH and ECD
Gayane Badalian-Very
992
Is JAK2V617F finally off the hook?
Ingeborg Hers and Alastair W. Poole
993
A step forward back to (induced) fetal
Nancy S. Green
995
Less (bacterial diversity) is more (deaths)
John E. Levine
BLOOD WORK
997
Nodular sclerosis Hodgkin lymphoma with classic Reed-Sternberg cells
Selina Jing Li and Suzanne Maria Vercauteren
998
Auer rods in dysplastic granulocyte
Anila Rashid
PLENARY PAPER
999
A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic
fibrosis is corrected by CFTR potentiator therapy
Kerstin Pohl, Elaine Hayes, Joanne Keenan, Michael Henry, Paula Meleady, Kevin Molloy,
Bakr Jundi, David A. Bergin, Cormac McCarthy, Oliver J. McElvaney, Michelle M. White,
Martin Clynes, Emer P. Reeves, and Noel G. McElvaney
PERSPECTIVES
1010
Mouse models in the study of chronic lymphocytic leukemia pathogenesis and
therapy
Giorgia Simonetti, Maria Teresa Sabrina Bertilaccio, Paolo Ghia, and Ulf Klein
REVIEW ARTICLE
1020
Evolving use of new oral anticoagulants for treatment of venous thromboembolism
Calvin H. Yeh, Peter L. Gross, and Jeffrey I. Weitz
v
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1029
Extracellular nucleotide and nucleoside signaling in vascular and blood disease
Marco Idzko, Davide Ferrari, Ann-Kathrin Riegel, and Holger K. Eltzschig
CLINICAL TRIALS AND
OBSERVATIONS
1038
Phase 1 study of twice-weekly ixazomib, an oral proteasome inhibitor, in
relapsed/refractory multiple myeloma patients
Paul G. Richardson, Rachid Baz, Michael Wang, Andrzej J. Jakubowiak, Jacob P. Laubach,
R. Donald Harvey, Moshe Talpaz, Deborah Berg, Guohui Liu, Jiang Yu, Neeraj Gupta,
Alessandra Di Bacco, Ai-Min Hui, and Sagar Lonial
1047
Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor
ixazomib in relapsed/refractory multiple myeloma
Shaji K. Kumar, William I. Bensinger, Todd M. Zimmerman, Craig B. Reeder,
James R. Berenson, Deborah Berg, Ai-Min Hui, Neeraj Gupta, Alessandra Di Bacco, Jiang Yu,
Yaping Shou, and Ruben Niesvizky
1056
Infection-related mortality in children with acute lymphoblastic leukemia:
an analysis of infectious deaths on UKALL2003
David O’Connor, Jessica Bate, Rachel Wade, Rachel Clack, Sunita Dhir, Rachael Hough,
Ajay Vora, Nick Goulden, and Sujith Samarasinghe
1062
Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis
Elisa Rumi, Daniela Pietra, Cristiana Pascutto, Paola Guglielmelli, Alejandra Martı́nez-Trillos,
Ilaria Casetti, Dolors Colomer, Lisa Pieri, Marta Pratcorona, Giada Rotunno,
Emanuela Sant’Antonio, Marta Bellini, Chiara Cavalloni, Carmela Mannarelli, Chiara Milanesi,
Emanuela Boveri, Virginia Ferretti, Cesare Astori, Vittorio Rosti, Francisco Cervantes,
Giovanni Barosi, Alessandro M. Vannucchi, and Mario Cazzola, on behalf of the Associazione
Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators
GENE THERAPY
1070
ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
Sonia Guedan, Xi Chen, Aviv Madar, Carmine Carpenito, Shannon E. McGettigan,
Matthew J. Frigault, Jihyun Lee, Avery D. Posey Jr, John Scholler, Nathalie Scholler,
Richard Bonneau, and Carl H. June
IMMUNOBIOLOGY
1081
Autonomous growth and increased cytotoxicity of natural killer cells expressing
membrane-bound interleukin-15
Masaru Imamura, David Shook, Takahiro Kamiya, Noriko Shimasaki, Sally M. H. Chai,
Elaine Coustan-Smith, Chihaya Imai, and Dario Campana
LYMPHOID NEOPLASIA
1089
Somatic mutation as a mechanism of Wnt/b-catenin pathway activation in CLL
Lili Wang, Alex K. Shalek, Mike Lawrence, Ruihua Ding, Jellert T. Gaublomme, Nathalie Pochet,
Petar Stojanov, Carrie Sougnez, Sachet A. Shukla, Kristen E. Stevenson, Wandi Zhang,
Jessica Wong, Quinlan L. Sievers, Bryan T. MacDonald, Alexander R. Vartanov,
Natalie R. Goldstein, Donna Neuberg, Xi He, Eric Lander, Nir Hacohen, Aviv Regev, Gad Getz,
Jennifer R. Brown, Hongkun Park, and Catherine J. Wu
1099
Plasmacytomagenesis in Em-v-abl transgenic mice is accelerated when apoptosis is
restrained
Cassandra J. Vandenberg, Paul Waring, Andreas Strasser, and Suzanne Cory
MYELOID NEOPLASIA
1110
Characterization of acute myeloid leukemia based on levels of global
hydroxymethylation
Leonie I. Kroeze, Mariam G. Aslanyan, Arno van Rooij, Theresia N. Koorenhof-Scheele,
Marion Massop, Thomas Carell, Jan B. Boezeman, Jean-Pierre Marie, Constantijn J. M. Halkes,
Theo de Witte, Gerwin Huls, Stefan Suciu, Ron A. Wevers, Bert A. van der Reijden,
and Joop H. Jansen, on behalf of the EORTC Leukemia Group and GIMEMA
vi
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1119
Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked
to the BRAFV600E mutation
Baptiste Hervier, Julien Haroche, Laurent Arnaud, Frédéric Charlotte, Jean Donadieu,
Antoine Néel, François Lifermann, Carles Villabona, Bruno Graffin, Olivier Hermine,
Aude Rigolet, Camille Roubille, Eric Hachulla, Thierry Carmoi, Maud Bézier,
Véronique Meignin, Marie Conrad, Laurence Marie, Elise Kostrzewa, Jean-Marie Michot,
Stéphane Barete, Valerie Taly, Karine Cury, Jean-François Emile, and Zahir Amoura, on behalf of
the French Histiocytoses Study Group
1127
Echinomycin protects mice against relapsed acute myeloid leukemia without adverse
effect on hematopoietic stem cells
Yin Wang, Yan Liu, Fei Tang, Kelsie M. Bernot, Reuven Schore, Guido Marcucci,
Michael A. Caligiuri, Pan Zheng, and Yang Liu
PLATELETS AND
THROMBOPOIESIS
1136
Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative
neoplasm
Lamia Lamrani, Catherine Lacout, Véronique Ollivier, Cécile V. Denis, Elizabeth Gardiner,
Benoit Ho Tin Noe, William Vainchenker, Jean-Luc Villeval, and Martine Jandrot-Perrus
RED CELLS, IRON, AND
ERYTHROPOIESIS
1146
Hydroxyurea-inducible SAR1 gene acts through the Gia/JNK/Jun pathway to
regulate g-globin expression
Jianqiong Zhu, Kyung Chin, Wulin Aerbajinai, Chutima Kumkhaek, Hongzhen Li,
and Griffin P. Rodgers
THROMBOSIS AND
HEMOSTASIS
1157
The endothelial protein C receptor enhances hemostasis of FVIIa administration in
hemophilic mice in vivo
Giulia Pavani, Lacramioara Ivanciu, Armida Faella, Oscar A. Marcos-Contreras,
and Paris Margaritis
1166
Postthrombotic syndrome following upper extremity deep vein thrombosis in
children
Maria L. Avila, Lucy Duan, Amanda Cipolla, Ashley Kim, Walter H. A. Kahr, Suzan Williams,
and Leonardo R. Brandão
TRANSPLANTATION
1174
The effects of intestinal tract bacterial diversity on mortality following allogeneic
hematopoietic stem cell transplantation
Ying Taur, Robert R. Jenq, Miguel-Angel Perales, Eric R. Littmann, Sejal Morjaria, Lilan Ling,
Daniel No, Asia Gobourne, Agnes Viale, Parastoo B. Dahi, Doris M. Ponce, Juliet N. Barker,
Sergio Giralt, Marcel van den Brink, and Eric G. Pamer
1183
MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem
cell transplantation in patients with myelofibrosis
Damiano Rondelli, Judith D. Goldberg, Luis Isola, Leah S. Price, Tsiporah B. Shore,
Michael Boyer, Andrea Bacigalupo, Alessandro Rambaldi, Marco Scarano, Rebecca B. Klisovic,
Vikas Gupta, Bjorn Andreasson, John Mascarenhas, Meir Wetzler, Alessandro M. Vannucchi,
Josef T. Prchal, Vesna Najfeld, Attilio Orazi, Rona S. Weinberg, Crystal Miller, Giovanni Barosi,
Lewis R. Silverman, Giuseppe Prosperini, Roberto Marchioli, and Ronald Hoffman
CORRESPONDENCE
1192
Blood collection methods affect cellular protein integrity: implications for clinical
trial biomarkers and ZAP-70 in CLL
Lisa S. Chen, Michael J. Keating, and Varsha Gandhi
1196
Activation of TRKB receptor in murine hematopoietic stem/progenitor cells induced
mastocytosis
Min Yang, Kezhi Huang, Guntram Büsche, Arnold Ganser, and Zhixiong Li
vii
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CONTINUED ON viii
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1198
Engraftment of donor cells with germ-line integration of HHV6 mimics HHV6
reactivation following cord blood/haplo transplantation
Enkhtsetseg Purev, Thomas Winkler, Robert L. Danner, Gary A. Fahle, Linda Cook,
Danielle M. Zerr, Keith R. Jerome, and Richard W. Childs
ERRATA
1200
Wolyniec K, Shortt J, de Stanchina E, et al. E6AP ubiquitin ligase regulates
PML-induced senescence in Myc-driven lymphomagenesis. Blood. 2012;120(4):
822-832.
1201
Eriguchi Y, Takashima S, Oka H, et al. Graft-versus-host disease disrupts intestinal
microbial ecology by inhibiting Paneth cell production of a-defensins. Blood. 2012;
120(1):223-231.
1201
Rothe A, Sasse S, Goergen H, et al. Brentuximab vedotin for relapsed or refractory
CD301 hematologic malignancies: the German Hodgkin Study Group experience.
Blood. 2012;120(7):1470-1472.
1201
San-Miguel J, Bladé J, Shpilberg O, et al. Phase 2 randomized study of
bortezomib-melphalan-prednisone with or without siltuximab (anti–IL-6) in
multiple myeloma. Blood. 2014;123(26):4136-4142.
OTHER DEPARTMENTS
xxiii
ib
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