From www.bloodjournal.org by guest on October 2, 2016. For personal use only. 14 AUGUST 2014 x VOLUME 124, NUMBER 7 CONTENTS COVER FIGURE Scanning electron micrograph of chronic lymphocytic leukemia B cell atop nanowires taken 24 h after plating, imaged with a Zeiss Ultra55 microscope, magnification 313710. See the article by Wang et al on page 1089. INSIDE BLOOD COMMENTARIES 985 Novel insights related to CF neutrophils Silvia M. Uriarte 986 Oral therapy for multiple myeloma: ixazomib arriving soon Philippe Moreau 987 First do no harm: infectious deaths in pediatric ALL Karen R. Rabin 989 Old and new news in CLL: “It’s the pathway, stupid!” Alexander Egle 991 A common progenitor cell in LCH and ECD Gayane Badalian-Very 992 Is JAK2V617F finally off the hook? Ingeborg Hers and Alastair W. Poole 993 A step forward back to (induced) fetal Nancy S. Green 995 Less (bacterial diversity) is more (deaths) John E. Levine BLOOD WORK 997 Nodular sclerosis Hodgkin lymphoma with classic Reed-Sternberg cells Selina Jing Li and Suzanne Maria Vercauteren 998 Auer rods in dysplastic granulocyte Anila Rashid PLENARY PAPER 999 A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy Kerstin Pohl, Elaine Hayes, Joanne Keenan, Michael Henry, Paula Meleady, Kevin Molloy, Bakr Jundi, David A. Bergin, Cormac McCarthy, Oliver J. McElvaney, Michelle M. White, Martin Clynes, Emer P. Reeves, and Noel G. McElvaney PERSPECTIVES 1010 Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy Giorgia Simonetti, Maria Teresa Sabrina Bertilaccio, Paolo Ghia, and Ulf Klein REVIEW ARTICLE 1020 Evolving use of new oral anticoagulants for treatment of venous thromboembolism Calvin H. Yeh, Peter L. Gross, and Jeffrey I. Weitz v BLOOD, 14 AUGUST 2014 x VOLUME 124, NUMBER 7 CONTINUED ON vi From www.bloodjournal.org by guest on October 2, 2016. For personal use only. 1029 Extracellular nucleotide and nucleoside signaling in vascular and blood disease Marco Idzko, Davide Ferrari, Ann-Kathrin Riegel, and Holger K. Eltzschig CLINICAL TRIALS AND OBSERVATIONS 1038 Phase 1 study of twice-weekly ixazomib, an oral proteasome inhibitor, in relapsed/refractory multiple myeloma patients Paul G. Richardson, Rachid Baz, Michael Wang, Andrzej J. Jakubowiak, Jacob P. Laubach, R. Donald Harvey, Moshe Talpaz, Deborah Berg, Guohui Liu, Jiang Yu, Neeraj Gupta, Alessandra Di Bacco, Ai-Min Hui, and Sagar Lonial 1047 Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor ixazomib in relapsed/refractory multiple myeloma Shaji K. Kumar, William I. Bensinger, Todd M. Zimmerman, Craig B. Reeder, James R. Berenson, Deborah Berg, Ai-Min Hui, Neeraj Gupta, Alessandra Di Bacco, Jiang Yu, Yaping Shou, and Ruben Niesvizky 1056 Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL2003 David O’Connor, Jessica Bate, Rachel Wade, Rachel Clack, Sunita Dhir, Rachael Hough, Ajay Vora, Nick Goulden, and Sujith Samarasinghe 1062 Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis Elisa Rumi, Daniela Pietra, Cristiana Pascutto, Paola Guglielmelli, Alejandra Martı́nez-Trillos, Ilaria Casetti, Dolors Colomer, Lisa Pieri, Marta Pratcorona, Giada Rotunno, Emanuela Sant’Antonio, Marta Bellini, Chiara Cavalloni, Carmela Mannarelli, Chiara Milanesi, Emanuela Boveri, Virginia Ferretti, Cesare Astori, Vittorio Rosti, Francisco Cervantes, Giovanni Barosi, Alessandro M. Vannucchi, and Mario Cazzola, on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators GENE THERAPY 1070 ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells Sonia Guedan, Xi Chen, Aviv Madar, Carmine Carpenito, Shannon E. McGettigan, Matthew J. Frigault, Jihyun Lee, Avery D. Posey Jr, John Scholler, Nathalie Scholler, Richard Bonneau, and Carl H. June IMMUNOBIOLOGY 1081 Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15 Masaru Imamura, David Shook, Takahiro Kamiya, Noriko Shimasaki, Sally M. H. Chai, Elaine Coustan-Smith, Chihaya Imai, and Dario Campana LYMPHOID NEOPLASIA 1089 Somatic mutation as a mechanism of Wnt/b-catenin pathway activation in CLL Lili Wang, Alex K. Shalek, Mike Lawrence, Ruihua Ding, Jellert T. Gaublomme, Nathalie Pochet, Petar Stojanov, Carrie Sougnez, Sachet A. Shukla, Kristen E. Stevenson, Wandi Zhang, Jessica Wong, Quinlan L. Sievers, Bryan T. MacDonald, Alexander R. Vartanov, Natalie R. Goldstein, Donna Neuberg, Xi He, Eric Lander, Nir Hacohen, Aviv Regev, Gad Getz, Jennifer R. Brown, Hongkun Park, and Catherine J. Wu 1099 Plasmacytomagenesis in Em-v-abl transgenic mice is accelerated when apoptosis is restrained Cassandra J. Vandenberg, Paul Waring, Andreas Strasser, and Suzanne Cory MYELOID NEOPLASIA 1110 Characterization of acute myeloid leukemia based on levels of global hydroxymethylation Leonie I. Kroeze, Mariam G. Aslanyan, Arno van Rooij, Theresia N. Koorenhof-Scheele, Marion Massop, Thomas Carell, Jan B. Boezeman, Jean-Pierre Marie, Constantijn J. M. Halkes, Theo de Witte, Gerwin Huls, Stefan Suciu, Ron A. Wevers, Bert A. van der Reijden, and Joop H. Jansen, on behalf of the EORTC Leukemia Group and GIMEMA vi BLOOD, 14 AUGUST 2014 x VOLUME 124, NUMBER 7 CONTINUED ON vii From www.bloodjournal.org by guest on October 2, 2016. For personal use only. 1119 Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to the BRAFV600E mutation Baptiste Hervier, Julien Haroche, Laurent Arnaud, Frédéric Charlotte, Jean Donadieu, Antoine Néel, François Lifermann, Carles Villabona, Bruno Graffin, Olivier Hermine, Aude Rigolet, Camille Roubille, Eric Hachulla, Thierry Carmoi, Maud Bézier, Véronique Meignin, Marie Conrad, Laurence Marie, Elise Kostrzewa, Jean-Marie Michot, Stéphane Barete, Valerie Taly, Karine Cury, Jean-François Emile, and Zahir Amoura, on behalf of the French Histiocytoses Study Group 1127 Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells Yin Wang, Yan Liu, Fei Tang, Kelsie M. Bernot, Reuven Schore, Guido Marcucci, Michael A. Caligiuri, Pan Zheng, and Yang Liu PLATELETS AND THROMBOPOIESIS 1136 Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm Lamia Lamrani, Catherine Lacout, Véronique Ollivier, Cécile V. Denis, Elizabeth Gardiner, Benoit Ho Tin Noe, William Vainchenker, Jean-Luc Villeval, and Martine Jandrot-Perrus RED CELLS, IRON, AND ERYTHROPOIESIS 1146 Hydroxyurea-inducible SAR1 gene acts through the Gia/JNK/Jun pathway to regulate g-globin expression Jianqiong Zhu, Kyung Chin, Wulin Aerbajinai, Chutima Kumkhaek, Hongzhen Li, and Griffin P. Rodgers THROMBOSIS AND HEMOSTASIS 1157 The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo Giulia Pavani, Lacramioara Ivanciu, Armida Faella, Oscar A. Marcos-Contreras, and Paris Margaritis 1166 Postthrombotic syndrome following upper extremity deep vein thrombosis in children Maria L. Avila, Lucy Duan, Amanda Cipolla, Ashley Kim, Walter H. A. Kahr, Suzan Williams, and Leonardo R. Brandão TRANSPLANTATION 1174 The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation Ying Taur, Robert R. Jenq, Miguel-Angel Perales, Eric R. Littmann, Sejal Morjaria, Lilan Ling, Daniel No, Asia Gobourne, Agnes Viale, Parastoo B. Dahi, Doris M. Ponce, Juliet N. Barker, Sergio Giralt, Marcel van den Brink, and Eric G. Pamer 1183 MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis Damiano Rondelli, Judith D. Goldberg, Luis Isola, Leah S. Price, Tsiporah B. Shore, Michael Boyer, Andrea Bacigalupo, Alessandro Rambaldi, Marco Scarano, Rebecca B. Klisovic, Vikas Gupta, Bjorn Andreasson, John Mascarenhas, Meir Wetzler, Alessandro M. Vannucchi, Josef T. Prchal, Vesna Najfeld, Attilio Orazi, Rona S. Weinberg, Crystal Miller, Giovanni Barosi, Lewis R. Silverman, Giuseppe Prosperini, Roberto Marchioli, and Ronald Hoffman CORRESPONDENCE 1192 Blood collection methods affect cellular protein integrity: implications for clinical trial biomarkers and ZAP-70 in CLL Lisa S. Chen, Michael J. Keating, and Varsha Gandhi 1196 Activation of TRKB receptor in murine hematopoietic stem/progenitor cells induced mastocytosis Min Yang, Kezhi Huang, Guntram Büsche, Arnold Ganser, and Zhixiong Li vii BLOOD, 14 AUGUST 2014 x VOLUME 124, NUMBER 7 CONTINUED ON viii From www.bloodjournal.org by guest on October 2, 2016. For personal use only. 1198 Engraftment of donor cells with germ-line integration of HHV6 mimics HHV6 reactivation following cord blood/haplo transplantation Enkhtsetseg Purev, Thomas Winkler, Robert L. Danner, Gary A. Fahle, Linda Cook, Danielle M. Zerr, Keith R. Jerome, and Richard W. Childs ERRATA 1200 Wolyniec K, Shortt J, de Stanchina E, et al. E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. Blood. 2012;120(4): 822-832. 1201 Eriguchi Y, Takashima S, Oka H, et al. Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of a-defensins. Blood. 2012; 120(1):223-231. 1201 Rothe A, Sasse S, Goergen H, et al. Brentuximab vedotin for relapsed or refractory CD301 hematologic malignancies: the German Hodgkin Study Group experience. Blood. 2012;120(7):1470-1472. 1201 San-Miguel J, Bladé J, Shpilberg O, et al. Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti–IL-6) in multiple myeloma. Blood. 2014;123(26):4136-4142. OTHER DEPARTMENTS xxiii ib Author Guide Classifieds SUBMISSION INSTRUCTIONS All manuscripts, including figures, should be submitted electronically at http://submit.bloodjournal.org to Editor-in-Chief Bob Löwenberg, MD, PhD. Before submitting your paper, review Blood’s Author Guide at http://bloodjournal.hematologylibrary.org/site/authors/ authorguide.xhtml. If you need help during the submission process, contact the Editorial Office by phone at 202-776-0548 or via e-mail at editorial@hematology.org. viii BLOOD, 14 AUGUST 2014 x VOLUME 124, NUMBER 7 From www.bloodjournal.org by guest on October 2, 2016. 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