Multiple-Tuned Narrow Band Preamplifier G.X. Shen MR Research Center, Department of Radiology University of Pittsburgh, Pittsburgh, USA Introduction Most MRI scanners equipped with spectroscopy capability and MR spectrometers use wide band preamplifiers to cover a wide range of different nuclear resonant frequencies. However, the major disadvantage of using a wide-band preamplifier is its low gain and higher noise figure. We have designed a quadrupletuned narrow-band preamplifier (0.5 dB noise figure) which can improve the SNR by about 20% compared to the wide-band preamplifiers (1.2 dB noise figure). Methods One of the most important factors for the design of a low noise figure preamplifier is the input resonant circuit at the first stage. We designed a high Q and low-loss matching circuit Due to the very small signal (level (mV) at the input to the preamplifier, commercial tuning diodes (varactors) with very high capacitance ratio (M/A-COM, Inc.) can be used to design ,the multiple-tuned preamplifier. The schematic diagram of a multiple-tuned preamplifier with low noise figure is shown in Fig. 1. VariableDC t AC coupling Fig. 1 Diagram of a multiple -tuned narrow band preamplifier using varactor through different DC bias. A GaAs tuning varactor with very high Q and capacitanceratio, MA46H204 was chosen (M/A-COM, Inc., Lowell, MA, USA). This varactor has a capacitanceratio of 10.0 and Q of 1,500 at an operating frequency of 50 MHz and reverse biased voltage of 4 V. A RF choke (4.7 mH) was used in the circuit for DC voltage bias. The variable capacitor is used for adjusting the frequency and is rated from 0.8-8 pF. The bandwidth of this tuning circuit depends on the Q of the varactor, the capacitor and the inductor at the input of the preamplifier. Normally, the Q of the capacitor is very high, thus improving the Q of the inductor is critical for the design of this narrow band preamplifier. The inductor is wound on a Teflon cylinder that is 70mm in length and 17mm in diameter. The inductor uses 16AWG wire and has 15 turns to approach 1.2 PH inductance. Because the SNR of a preamplifier is usually dominated by the first stage (2), the second stage was designed as a normal wide band amplifier to cover all designed RF frequencies. Results and Discussion: The prototype of a quadruple-tuned preamplifier has been implemented and tested in our electronic lab. Each nuclear frequency can be pre-tuned through DC bias and controlled by a modified pulse sequence,thus easily optimizing their performance. The gain of the preamplifier for all nuclei was measured as $1 by a Network Analyzer, HP 8753B, and noise figures measured by Noise Figure Meter, HP 8970B. The measured data at 1.5 T are listed in Table 1. 1H 39.3 10.7 19F 7Li 31P 38.8 35.2 34.7 Gain (dB) 10.5 8.8 9.2 Bandwidth (MHz) 0.47 0.46 0.48 0.49 Noise Figure (dB) Tablel. List of gain and noise figure of different nuclei for the multiple pre-tuned narrow band preamplifier. For this quadruple-tuned application, the tuning of preamplifier can be tirther simplified, because the frequencies of 1H (63.7 MHZ) and 19F (60.2 MHz) are so close, as are those of 7Li (24.8 MHz) and 31P (25.9 MHz); thus, 10 MHz bandwidth can cover both of them without significantly loss of gain (less than 3%). Summary: A prototype of a multiple-tuned narrow band preamplifier demonstrates high gain and low noise figure over a wide range of frequencies. This design can be used to improve SNR for high resolution MR and multi-nuclear MRI/MRS Reference: 1. RF and Microwave Semiconductors, p. 4-23, 1996, MA-COM and AMP Company, MA 0 1853, USA. 2. Dorf R.C., Electrical Engineering Handbook, CRC press, Inc., 1993. Acknowledgments: This work was supported by Whitaker Foundation, Public Health Service grant POlNS35945 and GE Medical Systems.