This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination. IEEE TRANSACTIONS ON NUCLEAR SCIENCE 1 Performance Study of a Wide-Area SiPM Array, ASICs Controlled A. J. González, S. Majewski, J. Barberá, P. Conde, C. Correcher, L. Hernández, C. Morera, L. F. Vidal, F. Sánchez, A. Stolin, and J. M. Benlloch Abstract—In this paper, the capabilities of a wide-area gamma ray photosensor based on a SiPM array are investigated. For this purpose, we have mounted an array of 144 SiPMs with mm and a pitch of mm, thus individual active area of covering an active area of mm . The measurements were performed by coupling the SiPM array to LYSO crystal armm , mm , and rays of different pixel size ( mm ) and 10–12 mm thicknesses. The SiPM array was controlled by means of three ASICs, and the SiPM signals were multiplexed in order to determine the gamma ray impact position by means of implementing the Anger logic algorithm in the ASIC. The optimum bias voltage and temperature dependence of the gamma ray sensor were determined. An energy resolution as good as 8%, for individual crystal pixels, were reached at 5 V overvoltage. The ASICs design allows one to “activate” different photosensor array areas. This feature has been used to evaluate the detector performance as a function of the crystal pixel size and the photosensor dark noise contribution. In this work we also show the system capability to provide depth-of-interaction (DOI) information by means of implementing a two-layer staggered approach. We have found that accurate DOI information is obtained when the ASICs enmm ( SiPMs). abled an SiPM active area as high as Index Terms—Application-specific integrated circuits (ASICs), Gamma-ray detectors, photodetectors, positron emission tomography (PET) instrumentation, scintillators. I. INTRODUCTION P HOTOMULTIPLIER tube (PMT) technology has been widely explored for a variety of applications, and nuclear medicine has made use of them for about 50 years. Recently, the routine use of magnetic resonance imaging (MRI) in medical practice and especially when combined with other functional imaging techniques such as positron emission tomography Manuscript received February 21, 2014; revised July 10, 2014; accepted September 16, 2014. Project funded by the Spanish Ministry of Economy and Competitiveness and co-funded with FEDER’s funds within the INNPACTO 2011 program. This work was supported by the Spanish Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I+D+I) under Grant FIS2010-21216-CO2-01 and the Valencian Local Government under Grants PROMETEOII/2013/010 and ISIC 2011/013. A. J. González, P. Conde, L. Hernández, L. F. Vidal, F. Sánchez, and J. M. Benlloch are with Institute for Instrumentation in Molecular Imaging (I3M), CSIC -Universidad Politécnica de Valencia—CIEMAT, 46022 Valencia, Spain (e-mail: agonzalez@i3m.upv.es). S. Majewski and A. Stolin are with the Department of Radiology, West Virginia University, Morgantown, WV 26506 USA. J. Barberá, C. Correcher, and C. Morera are with Oncovision S. A., 46013 Valencia, Spain. Color versions of one or more of the figures in this paper are available online at http://ieeexplore.ieee.org. Digital Object Identifier 10.1109/TNS.2014.2359742 (PET) has boosted the research efforts of several groups to demonstrate the capability of photosensors to work in strong magnetic fields without impact on performance. There are mainly two types of photosensors capable of this compatibility, the so-called avalanche photodiodes (APDs) and silicon photomultipliers (SiPMs). Both are, in general, large arrays of micro-APDs, but the first type works in the avalanche regime, whereas the SiPMs operate in the Geiger mode, over the self-quenched breakdown voltage. Each micro-APD is referred to as a cell and produces a signal when it detects one photon. The SiPM output is provided as the sum of all output cells. SiPMs have better timing response compared to APDs [1] as well as . However, both devices present the limiting high gain factor of dark noise. Due to the incompatibility of PMTs to work in magnetic fields such as those presented in MRI systems, SiPMs (also APDs) have been suggested to replace PMTs in the design of PET systems [2]–[4]. There are several efforts focusing on the appliSiPMs cation of individual and small arrays of SiPMs ( mm area each) for this purpose with significant sucof cess [5], [6]. A large-area, silicon-based detector of approxicm was recently presented [4]. These tests have mately demonstrated high spatial and energy performances but also temporal performance [7]. In particular, SiPMs are proposed for time-of-flight applications due to its fast response [8]. However, there are not yet that many developments using large-area arrays of SiPMs achieving good performanc. In this paper, we will show the good overall performance of an array of 144 SiPMs with final array dimensions of roughly cm . There are primarily two SiPM array readout approaches, namely networks based on analogue devices [9], [10], but very recently application-specific integrated circuits (ASICs) have also appeared to be good candidates [11]–[14]. There are several projects in which different resistor networks (also diodes) have been studied in detail for both PMTs and SiPMs [9]–[16]. The most important advantages of using this approach are good linearity, high dynamic range, and also good timing resolution. However, these methods are limited to provide information further than planar impact position and time. Moreover, they may result in a high system cost when designing a large field of view scanner. Depth-of-interaction (DOI) information is possible to be also determined using analogue readouts with methods such as the phoswhich [17] or additional photosensors, but also by methods in which the resistor network is upgraded to provide information related to the DOI [18]. The alternative of using ASICs has recently showed good results for photosensor readout, especially SiPMs, due to their 0018-9499 © 2014 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information. This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination. 2 IEEE TRANSACTIONS ON NUCLEAR SCIENCE entrance and exit faces were also polished, where the entrance additionally included an ESR reflector layer. A. Application-Specific Integrated Circuit Fig. 1. (Left) Stack of three boards with the SiPM array in the front. (Right) Photograph of the middle board showing the three ASICs. versatility [19]–[21]. They can be designed to provide high temporal performance but also accurate determination of the photon impact. They have been used for both crystal arrays and monolithic scintillators. In this work, we will describe a scalable ASIC that has been designed to control SiPMs [12]. We have put together arrays of 144 SiPMs that are ASICs controlled. In particular, three ASICs are required to control each 144-SiPM array. We will describe the design of the SiPM array and their potential use as a photodetector for gamma rays. We will show the first results obtained with this assemble using crystal arrays. II. MATERIALS Our research team has accumulated experience in the design and construction of dedicated PET systems, starting with the small animal PET called Albira [22], and then the dedicated breast PET named MAMMI [23]. The photosensors used in these systems were based on the well-established PSPMT technology. As with many other research groups, it was our recent goal to replace PMT sensors by SiPM technology in order to improve the photodetector performance. Arrays of SiPMs are envisaged to deliver high intrinsic spatial resolutions and good timing response, but also immunity to magnetic fields. We carried out a preliminary work with arrays of 256 MPPCs of the type S10362-11-050 from Hamamatsu, with an active area of mm and 50 m cell size [11]. They were mounted on a cm PCB with a pitch of 3 mm. Due to the dead area and the scintillation light coupling to the photosensor using special light guides [24], [25], we encountered limited detector performance. In order to improve operation, one alternative has been to use larger active-area SiPMs with a reduced gap between them. In particular, we have designed and mounted an array of 144 SiPMs from SensL. In this case we used SiPMs of the MicroFB-30035 SMT series that have an active area of mm with a total outside dimension of mm . These sensors are packaged in a mm clear molded reflow lead frame. This package is soldered in standard reflow ovens. The SiPMs were mounted with a pitch of 4.2 mm. The flatness of all 144 SiPMs was measured to be below m. The SiPM array active area covers mm . See Fig. 1. The measurements were performed with crystal arrays of different pixel size ( mm , mm and mm ) and 10–12 mm thickness. In all cases, the individual lateral crystal pixels were polished, and ESR (3M) reflectors were used. The The SiPM array was controlled by means of three ASICs [12], as shown in Fig. 1, right. These ASICs are a CMOS integrated front-end architecture. The chip is PSPMT and SiPM compatible, presents low gain dispersion among inputs, low noise, and high speed response [13]. The underlying architecture calculates the moments of the detected light distribution in an analog mode. Due to the additive nature of the moment calculation, the operation can be carried out on a single device or split it into several devices, adding the partial results afterward. All the operations are carried out in current mode, and the weighting operations are implemented using linear MOS current dividers. Weighting coefficients are programmable via an I2C bus and stored in 8-bit registers. Finally all the weighted currents are added together and introduced in an output current buffer [13]. Selecting the proper set of weights allows one to estimate many characteristic parameters of the light distribution, e.g., the centroids of the light distribution, their standard deviations, skewness, etc. The 144 ASIC inputs are replicated eight times. All the input signals are added forming eight linear combinations of the 144 input signals. In these experiments, the ASIC output 1 provided the data acquisition Ssystem (DAS) with the trigger signal. This output is obtained by loading identical coefficients to all SiPMs. ASIC output channels from 2 to 5 were programmed to deliver planar photon impact information. These signals were loaded with coefficient matrices representing the Anger logic (A, B, C, D), that is, diagonal gradient coefficients [26]. The sixth output provided DOI information, since it was calculated as the variance of the light distribution [27]. The remaining two channels were not programmed and used in these experiments. This particular ASIC allows one to connect SiPM devices with a terminal capacitance below 40 pF. The new SensL SiPMs provide, in addition to the standard output pF , an additional output (named FAST) with a terminal capacitance of only 30 pF. It has been shown the convenience of using this output for high time resolution measurements. Unfortunately, it was not possible to directly use this signal with the ASIC, because it has a positive signal polarity, not matching the negative input requirement of this particular ASIC. The solution we came with was to connect the FAST output to ground. In order to limit the current flowing through the outputs in this new implementation, an additional serial resistor was mounted with resistance values ranging from 0.1 to k ( k was the current selected value). In this way the final terminal capacitance of the anode-cathode signal is 30 pF, matching well with the ASIC requirements. Fig. 2 depicts the circuitry schematic used for this array and ASIC compatibility. B. Data Acquisition System All output signals (trigger and impact positioning) are transferred to the DAS by means of coaxial cables with impedance. The DAS used in the present experiments was mainly composed of a trigger board and multichannel analog-to-digital converters (ADCs) boards, both in CAMAC This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination. GONZÁLEZ et al.: PERFORMANCE STUDY OF A WIDE-AREA SIPM ARRAY, ASICS CONTROLLED Fig. 2. (Left) Circuit schematic with an output capacitance of pF in park and 700 pF. (Right) ASIC output trigger signals, 100 mV and allel with 50 ns plot divisions. format. The trigger signal (calculated from the sum of all SiPMs signals) uses a double leading-edge approach, and the main threshold was set to mV, suppressing most of the electronic noise. The trigger signal threshold reduces low-energy impacts that have been multiplexed along the SiPM array. As an energy window around the 511 keV peak is set when working with PET applications, the effect of the threshold level on the spatial resolution is low. The integration time for each ADC channel was set to 192 ns. All measurements presented in this report were performed in singles mode (no coincidence). Thus, all trigger signals above the selected threshold enabled a synchronized gate signal that started the digitization of the output ASIC channels on the ADC. These data were sent through Ethernet to a personal computer workstation and stored in a list mode. Specially designed applications were used for data presentation and analysis. III. MEASUREMENTS AND RESULTS We have evaluated the performance of a wide-area SiPM array in terms of spatial resolution, energy resolution, and DOI capabilities, as a function of temperature, Vop, and crystal size. Since temporal resolution is also an important parameter for PET applications, a deep analysis concerning timing performance with these sensor arrays has been recently carried out by the authors in a separate work [28]. A. SiPM Array Bias Adjustment The used SiPMs have their breakdown voltage at about 24.5 V. The whole SiPM array was biased to a common voltage. By analyzing the energy and intrinsic detector spatial resolution, we determined the optimum operational overvoltage for these arrays. In these experiments, the SiPM arrays were coupled to a crystal array of elements with mm size each and through an acrylic spreader window of 1.7 mm thickness. Optical grease with an index of refraction of 1.46 (Visilox V-788) was used to couple all these elements. In the experiments carried out to define the best Vop and temperature parameter, the ASICs were programmed to only return signal information from one quadrant of the SiPMs array. This configuration offers sufficient information about optimum bias and temperature without the need of programming the entire SiPM array. The detector block assembly was located inside a thermal controlled environment at a detector temperature of 3 Fig. 3. (Left) Contour plot of mm crystal array pixels at 30 Vop, for at the 511 keV photopeak. (Top right) Energy resan energy window of olution of nine pixels as a function of the Vop. The red line is the first-order exponential decay fit to the data. (Bottom right) Individual pixels energy resolutions and average are plotted. about 17 C). A gamma ray source was used based on a matrix of sources with a total activity of about Ci. The source array was located close to the entrance face of the crystal array. As observed in Fig. 3 all crystal pixels could be distinguished. The operational voltage (Vop) of the array was sequentially varied from 25 V to 31 V and the data stored in list mode files. Several regions of interest (ROI) around one crystal pixel and a group of nine pixels were analyzed in order to study the energy resolution. On the right side of Fig. 3 we have depicted the determined energy resolution (%) as a function of the Vop in volts for the group of pixels (top) and for individual pixels (bottom). The energy resolution for each histogram was determined by fitting a Gaussian curve. The percentage is calculated as the ratio of full width at half maximum (FWHM) to the centroid value. In these figures, we observe an exponential decay of the energy resolution, improving with the increase of the Vop. The ratio of the 1274/511 keV peaks in as a function of the Vop resulted on a standard deviation of only 2%, suggesting a negligible nonlinearity effect of the detector assembly. Energy resolution values for individual pixels as good as 9% were measured, at Vop of 29–30 V. Additionally to the energy resolution, the spatial resolution was also evaluated as a function of the Vop. Here, profiles through one row of crystal pixels were analyzed. We observed an improvement of pixel identification for Vop higher than 28.5 V, with performance remaining almost constant up to 30.5 V. Fig. 4 depicts profiles through one row of crystal pixels as a function of different Vop. Based on these results, we selected an optimal Vop value of V for the next experiments. B. Temperature Dependence SiPMs are known to be temperature sensitive, showing better performance at lower temperatures. This effect is characteristic for solid-state-based detectors due to thermal charge generation. As for the tests on the optimum bias, we also analyzed here the intrinsic detector spatial resolution and the energy resolution, but as a function of the detector block temperature. In this experiment, the detector block temperature was controlled by means of a closed box made out of Porexpan. This box was also covered with a dark blanket. The temperature inside the box was This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination. 4 Fig. 4. Profiles through one row of crystal pixels as a function of Vop varying energy window around 511 keV. from about 25 V to 31 V, for a IEEE TRANSACTIONS ON NUCLEAR SCIENCE Fig. 6. Profiles through one row of crystal pixels as a function of detector temaround the perature varying from 20 to 30 C. An energy window of 511 keV photopeak was selected. (Left) Twelve-pixel profile. (Right) Detail for three edge pixels. temperatures below C (Fig. 6). As expected, an overall detector improvement is observed at low temperatures. C. Spatial Resolution Dependence on SiPM Dark Noise Fig. 5. (Top) Energy resolution (FWHM in %) as a function of temperature for one (opened squares) and nine (full circles) crystal pixels, respectively. (Bottom) Photopeak centroid (ADC channel) as a function of the temperature. regulated by means of a chiller that cyclically pumped glycolic water to a cold plate located inside the box. The detectors were positioned on top of such a cold plate. The experiments were carried out with a crystal array composed of pixels with mm transversal size. Two ROI around one and nine pixels were considered for all temperature measurements that ranged from 20 to 40 C. Fig. 5, bottom, shows the 511 keV photopeak ADC channel as a function of the temperature. As expected, there is a gain increase of the photon detection efficiency (PDE), proportional to the decrease of the system temperature. We have determined a gain increase of C. In Fig. 5, top, we have plotted the energy resolution for one and nine crystal pixels, as a function of the detector temperature. An energy resolution improvement is observed at lower temperatures, reaching values of 7.5% for single crystal pixels. A profile of one row of crystal pixels provides a visual demonstration of the detector intrinsic spatial resolution improvement with the temperature decrease. This is observed as a more prominent signal-to-noise ratio (SNR) measure at In this section, we present a unique study in which we have investigated the intrinsic resolution of the detector block, as a function of the SiPM array size. The measurements were carried out at 30 Vop. The novelty of this work is the capability of varying the area of SiPMs contributing to the trigger signal and center-of-gravity (CoG) determination for the planar photon impact position (ASICs outputs second to fifth). This was possible by programming the three ASICs with different trigger and CoG matrices according to the SiPM area under study. Areas of , , , and SiPMs were selected. All 144 SiPM signals are transferred to the ASICs without the capability for individual amplitude thresholds. Individual thresholds for each SiPM prior to the ASIC [4], [10]or clustering SiPMs around the highest peak channels [29] to reduce SiPM noise contributions have been studied by other groups but not considered in this ASIC development. After ASIC calculations, the eight calculated signals are fed to the DAS, where only an amplitude threshold can be used on the trigger signals. In order to isolate selected SiPM array areas both the trigger and the four impact determination signals outside these areas were programmed to zero, and the new matrices recalculated for the planar impact characterization. The experiments were carried out for crystal arrays with pixel sizes of , , and mm , respectively. In order to attain the best SiPM array response uniformity, spreader windows of 1.7, 1.7, and 2.1 mm were used, respectively. Fig. 7 (left) shows, using contour plots, the results for crystal pixel sizes of mm for different SiPM arrays active areas. The data were taken in single mode, and the representations shown in the following figures are depicted for an energy window of about 400–600 keV (at C). When SiPMs are enabled, some border effects and a poor resolution at the array edges are observed. These effects are significantly reduced for an active area defined by SiPMs and almost completely This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination. GONZÁLEZ et al.: PERFORMANCE STUDY OF A WIDE-AREA SIPM ARRAY, ASICS CONTROLLED Fig. 7. Contour plots for crystal arrays of mm (four plots on the left) mm (four plots on the right) sizes, as a function of the SiPM and of active area. Fig. 8. Profiles through one row of crystal pixels mm for different SiPM areas. The black dashed and red solid lines represent the average noise and signal values, respectively. vanished for arrays smaller than SiPMs. Please note that the area for SiPMs has dimension of roughly mm , and the one for still covers cm . The latter size is still large and comparable to sizes used in many studies carried out elsewhere [29], [30], with active dimensions of mm and mm , respectively. The experiments carried out with pixels of mm size were performed at a lower temperature C in order to improve the system’s performance (Fig. 7, right). The results for an area defined by SiPMs again showed lower spatial resolution compared to those obtained for smaller SiPM areas. In both and mm pixel cases, when SiPMs and smaller areas were selected, the achieved spatial resolution allowed one to resolve most of the pixels within the active field of view. In Fig. 8, the profiles through one row of crystal pixels for the four measured cases when using mm pixel sizes are shown. These results confirm that the level of accumulated noise is a constant background per unit of area that reduces the peak-to-valley determination when increasing the SiPM active area. The SNR data obtained through the profiles as those exemplified in Fig. 8, for the mm , mm , and mm 5 Fig. 9. SNR as a function of the number of SiPMs for the different crystal pixel sizes. pixel cases are included in Fig. 9. The SNR values were calculated as the peak-to-valley ratio of one profile. The error bars are the standard deviations of peaks and valleys counts, respectively. We observed an improvement of the signal when reducing the number of SiPMs. Another source of noise such as the natural radioactivity of the Lutetium in the scintillator is hardly contributing to the SNR data, since an energy window around the 511 keV photopeak was applied, in addition to its low rate compared to the sources. These tests suggested that smaller crystal pixels of mm would hardly be resolved for the entire SiPM array. In order to show the system capability to resolve these small pixels, we directly analyzed the case for SiPM arrays, which is comparable with studies carried out by other groups. A smaller area of SiPMs was also tried in order to observe if an improvement could further be observed. However, as Fig. 9 depicts, there is no improvement for areas smaller than SiPMs. In Fig. 10 we have plotted the results for mm pixels and two array areas. In the bottom, a profile of one row of crystal pixels is plotted. The behavior of the SNR values for and SiPMs in the case of a mm pixel area could be explained if we consider that the relatively small amount of light (i.e., signal) collected in that case cannot compensate for the noise reduction produced when the and SiPMs configurations are used. In this sense, the mm pixel area configuration seems to limit the SNR improvement when reducing the photosensor area. D. Depth of Interaction With Crystal Arrays In the search of replacing PSPMT by arrays of SiPMs, photon depth of interaction has to also be preferentially resolved. One of the most popular approaches when using crystal arrays to return DOI information is the so-called phoswich concept [17]. Here, crystal arrays with different decay times are assembled together in a stack, one on top of the other. The impacted crystal layer is determined by differentiating the distinct scintillation decay time of that layer. When high intrinsic spatial resolutions are reached, an alternative to the phoswich is the staggered approach [31]. In this method, the pixels on one crystal layer are shifted in the X and Y directions, for example, by the size of half This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination. 6 IEEE TRANSACTIONS ON NUCLEAR SCIENCE Fig. 11. Staggered approach reading 1274 keV energy windows. SiPMs for the 511 keV and Fig. 10. (Top) Contour plots for crystal arrays of mm together with (bottom) the profiles through of one row. (Left) 6 6 SiPMs area. (Right) 3 3 SiPMs. The measures were taken at an assembly temperature of 14 C. pixel. Therefore, the light of one top pixel is shared among four pixels on the bottom layer. The layer identification is typically done by CoG, although other methods like direct pixel identification could be enabled. There is also a possibility to combine the phoswich approach with the staggered approach to maximize the number of distinguishable scintillation layers in the package. As a proof of concept, we mounted two blocks of mm LYSO pixel size following the staggered configuration. The block covered an area of approximately mm , and the entire assembly was kept at 13 C. The thicknesses of the two slabs were 10 mm each. We again run several tests varying the number of activated SiPMs. When the whole array was enabled, it was hard to distinguish between the two crystal slabs. Note that when using the described ASICs readout, even if only a portion of the SiPM array is covered by crystals, all SiPM signals (including noise) contribute to the CoG determination. In Fig. 11 the results are shown for energy windows centered at 511 and at 1274 keV, respectively. The resolution and pixel layer determination improves with the reduction of the SiPM array area, as expected. When a smaller active area of 8 8 SiPMs was programmed, they were differentiated. The top of Fig. 12 shows the sequence of results for the staggered approach with mm pixels, as a function of detection areas. In the bottom of Fig. 12, the profiles of two consecutive rows (i.e., crystal layers) for the SiPM case are shown. Well-differentiated top and bottom scintillation layers for this configuration are visible. The higher number of events in the top curve correlates to the location of the gamma ray source, being above this crystal slab, while the second layer was shielded by the first array. Fig. 12. (Top) Contour plots for the staggered configuration at 511 keV window as a function of the number of activated SiPMs. (Bottom) The profiles for two consecutive rows of pixels. (Solid line) From top layer. (Dashed line) From bottom layer. IV. DISCUSSION AND CONCLUSIONS In this paper, we have shown the design of a gamma ray photosensor based on an array of SiPMs, ASICs controlled, in order to replace PSPMTs in some dedicated PET systems. The detector module covers an active area of about cm , well matching the area of H8500/H9500 PSPMT. A special circuit configuration of the SiPM array had to be implemented in order to make it compatible with our previously developed ASIC. This new circuitry has not shown performance degradation at the rate levels that these experiments were carried out at. The bias voltage and temperature experiments showed the expected dependence of the SiPMs assembly with these parameters. Nevertheless, we found the present results to be of practical importance, since there are only few reported studies with SiPM arrays of similar dimensions cm studying these effects [32]. An energy resolution as good as 8%, for individual crystal pixels, was reached at 5 V overvoltage. The temperature stabilization method that we have used has nicely worked in the laboratory environment, but other methods are being studied in This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination. GONZÁLEZ et al.: PERFORMANCE STUDY OF A WIDE-AREA SIPM ARRAY, ASICS CONTROLLED 7 Summarizing, a detector block combining a SiPM array that is controlled with three ASICs, has been shown to return a good tradeoff performance. A unique ASIC versatility individually controlling the loaded matrix coefficients has allowed us to provide information on the detector behavior as a function of the chosen SiPMs array area. REFERENCES Fig. 13. Three-dimensional representation of the generated field of view for a PET system formed by ten photosensor arrays (white cylinder) compared to alternatives approaches. The left sketch shows the superposition of a smaller field of view in red color with higher image performance when only half array is activated in the transaxial plane. The right side depicts the example when the half active array is in the axial direction, defining an improved performance with shorter axial length (green color). order to extend the cooling approach to a higher number of detector blocks. We found an overall good performance of the entire detector block (crystal array, SiPMs matrix and ASICs PCB) when coupled to pixel arrays with mm size at 30 Vop and detector temperatures below 20 C. For smaller pixel sizes starting from mm , we observed that if the whole SiPM assembled array is activated, it is hard to reach a good detector performance. However, for a SiPMs array of devices and smaller, there is also a good detector performance. The active area defined by such an array, would cover about mm , slightly above some of the current PMT-based or APD-based commercial PET imagers. One of the most interesting features of the studied detector block encountered during the performed experiments has been the capability of the ASICs to allow one to define different photosensor array areas. This option has permitted the evaluation of the detector performance as a function of the crystal pixel size and the dark noise contribution from the changing active detector size. As a future development work one might think on a system implementation combining both a moderate spatial resolution and a high-resolution detector mode. The latter would be constrained for instance by a reduced axial or transaxial field of view. See Fig. 13. 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