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Medical University of South Carolina Neurosciences
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Volume 7 • Issue 2 • August 2014
"Select Step from an Anterior Cervical
Discectomy and Fusion Procedure"
© 2014 Medical University of South Carolina. All rights reserved.
www.MUSC.edu/neurosciences
Neuronews Credits
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Executive Editors
Bruce Ovbiagele, MD, MSc
Sunil Patel, MD
VOLUME 35, NUMBER 8, AUGUST 2014
Editors
Kelly Krajeck
Beth Whitaker, MHA
Emma Vought, MS
View this journal online at wileyonlinelibrary.com
Dr. Bruce Ovbiagele
Dr. Sunil Patel
MUSC Neurology
MUSC Neurosurgery
Photography & Writer
MUSC Staff
This newsletter is made possible from the generous contributions of MUSC Neurosciences
Submission, Illustration & Design
faculty and staff. The success of this publication is dependent upon this support. Thank you
Emma Vought, MS
Weston DeWolff
for your interest, time and information. For inquiries, suggestions or submission information
please email vought@musc.edu.
1
8
"Select Step from an Anterior Cervical
Discectomy and Fusion Procedure"
Cover Image by Weston DeWolff
Table of Contents
14
© 2014 Medical University of South Carolina. All rights reserved.
Featured Stories
1-4
News & Publications
5-9
Alumni & Academics
10-12
Employee Update & Social News
13-15
Clinical Trials & Grants
16-18
News
Dr. Edward Kosnik and his daughter, Dr. Libby Kosnik Infinger, have worked side-by-side
at the MUSC Pediatric Neurosurgery unit. Photo by Grace Beahm, Post and Courier
Father-daughter neurosurgeons operate
on brains together
Lauren Sausser // of the Post and Courier Staff
What seemed like only a minute ago, Ed Kosnik, M.D., was teaching
his daughter how to ride a bike. The next, she was standing next to
him in the operating room at MUSC.
"It was a pretty awesome experience, when you think that someone
whose diapers you changed is now capable of opening up your head
and doing the right thing," said Kosnik, who is an assistant professor in
the Department of Neurosciences. "You just sit there and shake your
head and say, 'Oh, my God.' But Libby's always been one who has
been ready to do something, in some ways."
His very capable, now 35–year–old daughter, Libby Kosnik Infinger,
M.D., was, until graduation June 14, the chief resident of MUSC's
neurosurgery program. She leaves Charleston later this summer to
complete a one–year fellowship at Cincinnati Children's Hospital,
where she'll specialize in pediatric neurosurgery, just like her dad.
Certainly, this isn't the first time a daughter has followed in her
father's footsteps, but this situation is special.
The Kosniks are the only known father–daughter duo in the pediatric neurosurgery specialty across the country who regularly operate
side–by–side.
Kosnik, 69, suspended his retirement in 2013 and joined the neurosurgery department at MUSC, where Infinger had been training
as a resident since 2007. He previously worked several decades as a
pediatric neurosurgeon in Columbus, Ohio.
"It was great," Infinger said. "It's funny. We have very similar personalities. We've always done things together, gone fishing, projects
around the house. It was different because, you know, you're operating, but we've always had a close relationship."
They operate on children together at least once a week: patients
with spinal defects, brain tumors, babies born with water on their brain.
Their last operation together, at least for the next year until Infinger
returns to MUSC after her fellowship, was June 13.
"I think this is a very unique experience," Kosnik said. "I've known a
lot of neurosurgeons and — you look at all the numbers of neurosurgeons — I don't think there are any other father–daughter combinations, certainly not in pediatrics."
Even as a child, Infinger remembers she was curious about what her
dad did for a living.
“In second grade, there was a girl that sat in front of me that he did
surgery on. Every day, I could look at her scar when she came back
to school and that really got me interested in seeing what he did, and
exactly what he did as a pediatric neurosurgeon."
Kosnik remembers the patient, but tells the story differently. "I
asked (Libby) what the scar looks like and she said, 'Yucky!' "
The early aversion eventually wore off. While her dad never pushed
her into neurosurgery, it turned out that's what she enjoyed most in
medical school. She also saw firsthand the kind of lifelong impact
pediatric neurosurgeons had on their patients.
Ed Kosnik's fan base is huge, she acknowledged. In 2011, when her
dad spent several weeks in an intensive care unit after heart surgery,
the Caring Bridge website the Kosnik family set up to keep friends
up to date on his progress received 80,000 hits. He estimates he
performed some 15,000 operations during his career in Columbus.
"I had one family tell me once, 'Thanks for giving up a little bit of
your dad so he could be a dad to all these other kids out there,' "
Infinger said. "But I never felt like he missed anything important. He
was there whenever I needed him."
Editor’s note: The article ran June 15 in The Post and Courier and is reprinted with permission.
Medical University of South Carolina Neurosciences // neuronews
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News
(Left) Dr. Jim Edwards reflects on his patient experience at MUSC. (Right) Dr. Jim Edwards, right, jokes with neurointerventionalist Dr. Imran
Chaudry, left, and Comprehensive Stroke Program’s Dr. Ed Jauch during his April 14 visit to MUSC Hospital. Photos by Sarah Pack, Public Relations
Former president thanks brain activation team
Mikie Hayes // Public Relations
It was June 1999. MUSC president, James B. Edwards, D.M.D.,
took time from his busy schedule to stroll the hospital halls shaking
hands and returning hugs. On his way to visit a heart patient at the
Palmetto Pavilion, Dr. Edwards asked a nurse if her lab had delivered
her puppies yet and an orderly if the fish were biting over on the
creek.
Both answered yes and lively conversation about family and life in
the Lowcountry ensued.
This was a typical occurrence in the life of the medical university
president who knew his people by name and enjoyed being among
them. It didn’t matter what day or what floor, Dr. Edwards was always a
welcomed caller and patients and employees alike were happy to see
him round the corner.
After serving as South Carolina’s governor and secretary of energy
in President Reagan’s cabinet, Dr. Edwards assumed the presidency of
MUSC in 1983. For 17 years he committed his time and energy to the
institution as president and another decade–plus working on special
projects. In all the years he spent establishing programs and recruiting
faculty, he never expected to be back on campus for such a personal
reason: to thank doctors and nurses for saving his life.
On June 7 2013, at about 4:30 a.m., Dr. Edwards fell to the floor, unable to move his left arm or leg or get up. Still able to communicate,
he called to his wife, Ann, a retired R.N., who recognized his complete paralysis on one side as a stroke. She immediately called EMS,
although Dr. Edwards protested it wasn’t necessary.
“Jim argued that he was not having a stroke, as many stroke patients
do. Time was of the essence. He was not in a position to call the shots,
so I took control of the situation. During a medical emergency, there
has to be a change in the chain of command,” she said. “The cardinal
thing to do is to seek help.”
Mrs. Edwards also called to granddaughter, Catharine Wingate,
who lives on their property. She came immediately to help. Wingate,
who will graduate in August from the Physician’s Assistant program
at the MUSC College of Health Professions, provided a great deal of
assistance and support while they waited for EMS.
Fortunately, Dr. Edwards’ primary physician, Donald Fox, M.D., associate professor of medicine at MUSC, had given his private number
to the Edwardses with instructions to call him if they needed him. And
need him they did.
“I called Dr. Fox and told him Jim was suffering a massive stroke.
He immediately called MUSC to alert them of the situation and his
forethought directly affected Jim’s outcome.”
When Fox phoned ahead to MUSC, the Brain Attack Team was
activated. The team, comprised of emergency physicians; neurology
attending physicians, fellows, and residents; neurointerventionalists;
a CT tech; pharmacist; and lab personnel, was literally waiting in the
Emergency Department for Dr. Edwards’ ambulance to arrive.
Upon arrival, he had a CT scan and neurological exam, results of
which showed he was suffering a life–threatening ischemic stroke.
Subsequently, a CT angiography was performed. This made it easier
for doctors to see his blood vessels and they determined that blood
was not flowing in his carotid artery on the right side, indicating a
complete blockage in his neck. A large clot had also made its way to
the middle cerebral artery in his brain...
To read the rest of this story visit the Catalyst at: http://academicdepartments.musc.edu/catalyst/archives/2014/5-2edwards.htm
Medical University of South Carolina Neurosciences // neuronews
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Featured Story
Controlling BP reduces chance of second stroke
Heather Woolwine // PUblic Relations
CHARLESTON – Stroke survivors who consistently
control their blood pressure may reduce the likelihood of
a second stroke by more than half, according to new research in the American Heart Association journal Stroke.
Study authors, including Bruce Ovbiagele, M.D.,
MUSC Department of Neurology and Neurosurgery
chairman and professor, found that among individuals
with elevated blood pressure at baseline (systolic blood
Dr. Ovbiagele
pressure over 153 mm Hg), second stroke risk was
reduced by 54 percent among participants who kept their blood
pressure under control more than 75 percent of the time, compared with those who kept it under control less than 25 percent
of the time. Unfortunately, fewer than 30 percent of participants
maintained consistent blood pressure control more than 75 percent of the time.
“Over time, a patient may average a blood pressure that falls
within normal, but this study suggests that providers and patients
should also factor in the proportion of time (or visits) in which
that patient’s blood pressure stays within control versus not,”
Ovbiagele said. “Since South Carolina has one of the highest
stroke rates in the nation, and many strokes are readily preventable
through good blood pressure management, targeting the maintenance of blood pressure control consistently over time following
a stroke could be a helpful way to lessen the personal and public
burden of stroke in our state.”
Researchers analyzed the results from the Vitamin Intervention
for Stroke Prevention (VISP) trial, which enrolled 3,680 ischemic
stroke patients ages 35 and older in 1996-2003. Ischemic strokes
are caused by a clot in a blood vessel supplying the brain. Participants had been tested for several factors, including blood pressure
levels at baseline, a month after the start of the study, at six months
and every six months thereafter up to 24 months. The American
Heart Association National Scientist Development Award funded
this research.
Researchers determined results after controlling for age, sex and
prior history of stroke, heart disease and other factors. Blood pressure
was considered “controlled” at 140 mmHg over 90 mmHg or lower.
“Generally, when we have looked at the effect of blood pressure
on stroke outcomes, we have looked at averages over time,” said
Amytis Towfighi, M.D., study lead author and assistant professor
of neurology at the Keck School of Medicine at the University of
Southern California in Los Angeles. “But it’s not enough to control
blood pressure some of the time. Averages do not take into account variability in blood pressure readings from one check to the
next. Those fluctuations in blood pressure may be associated with
greater cardiovascular risk. Changes in care management may be
needed to ensure patients maintain consistent control of blood
pressure.” Rather than check blood pressure during clinic visits
only, it should done regularly, perhaps at home by machines that
can remotely transmit the data, she said.
Reducing salt intake, eating a healthy diet (rich in whole grains,
fruits and vegetables) and exercising regularly can also reduce
stroke risk.
Study: Stroke hospitalization on the rise among some black patients
Lauren Sausser // Of The Post and Courier staff
New research shows that hospitalizations for black
stroke patients younger than 65 in South Carolina
jumped more than 17 percent between 2001 and 2010,
while stroke hospitalizations among middle-age white
patients did not change.
The study, published last week by the American Heart
Association, also reports that stroke hospitalizations decreased in black and white patients older than 65 years.
Dr. Feng
The study analyzed more than 84,000 records for
stroke patients discharged from South Carolina hospitals during that decade.
"Excess strokes among blacks as well as the lingering racial disparity in the younger groups represent a serious public health issue," said Wuwei (Wayne) Feng, M.D., assistant professor, MUSC
Department of Neurosciences, a neurologist and the study's lead
author, in a prepared statement.
South Carolina is included in a swath of Southern states called
"the stroke belt." The state has some of the highest rates of stroke
and stroke–related deaths in the country.
MUSC's telestroke program, founded in 2008, connects several
rural hospitals across the state with specialists in Charleston, who
can provide timely, remote care without transporting patients from
their own community's hospital.
The program intends to improve outcomes among stroke patients who live too far from acute, stroke-ready hospitals and primary stroke centers. Palmetto Health operates a similar program,
connecting rural stroke patients with experts in Columbia.
Stroke is caused when a clot blocks a blood vessel in the brain,
or the blood vessel ruptures, preventing oxygen flow to brain cells,
according to a press release about the new study. Risk factors
include high blood pressure, smoking and diabetes.
"Our results show the importance of staying healthy, exercising
and eating well, and starting these healthy habits while you are still
young," Feng said.
Editor’s note: The article ran June 23 in The Post and Courier and
is reprinted with permission.
Medical University of South Carolina Neurosciences // neuronews
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Featured Story
Neurosurgeons and
psychiatrists join ranks
Dawn Brazell // MUSC News Center
Operating on patients’ brains on a daily basis, neurosurgeon
Istvan Takacs, M.D., can be hard to impress.
When he talks of one unusual case at MUSC, though, there’s
wonder in his eyes. The case involves a patient who has four electrodes in his brain to create “an electric cloud” to treat his obsessive compulsive disorder and Parkinson’s disease.
“It rocks to be a neurosurgeon when you get to do things like this,”
he said of his collaboration with interventional psychiatrists at MUSC.
Traditionally, psychiatrists and neurosurgeons have approached the
treatment of the brain from polar–opposite perspectives.
“You traditionally think of psychiatrists as talkers or medicators. These psychiatrists are all beyond that,” he said of the brain
stimulation techniques that are transforming the field and creating
powerful, new therapeutic partnerships.“The more input you get
from more people, it can only be good. When you get to work
with people who chose to work in a completely different field
of medicine, and then you spend decades of your lives learning
things in different directions, and here we are. We are in this thing
together for the same ultimate purpose.”
Nolan R. Williams, M.D., who is chief resident of Combined
Neurology and Psychiatry and the patient’s interventional psychiatrist, agrees.
“There were probably 15 psychiatrists and neurologists and
neurosurgeons packed into Dr. Takacs’ office planning the surgery.
Everybody was equally excited, and everybody knows their role
in all of it and respects one another for each other’s role,” he said.
“That tells us a lot about how medicine is moving in general to a
much more collaborative mentality.”
It’s a shift patients, such as this one with the bilateral DBS
implant, depression for most of his life that medications have failed
to treat adequately. Several rounds of electroconvulsive therapy
also have failed to relieve his symptoms. In his 50s, the patient
faced a new challenge: Parkinson’s disease. He agreed to have
deep brain stimulation treatment, with two electrodes placed in his
subthalamic nucleus. When the procedure brought him relief from
his Parkinson’s symptoms, he wondered if it also could treat his
lifelong obsessive compulsive disorder that has been so intense it
compelled him to check the garbage, retrace his footsteps and feel
hopelessly depressed.
Takacs, Williams and their colleagues thought it was worth a try
since implanting the second set of electrodes would offer a unique
opportunity to see how the bilateral electrodes would interact, especially given the placement into the patient’s nucleus accumbens,
or reward circuitry portion of the brain. Beyond treating his OCD,
the hope was this also could relieve the man’s depression and
apathy, symptoms often seen in patients with Parkinson’s disease.
In July 2013, he received his second set of electrodes. Interventional psychiatrists have been adjusting his electrode settings
through a “brain pacemaker” that is implanted in the chest and
monitoring his reactions and progress. It takes months to see what
effect treatment will have.
Williams said the patient is no longer having suicidal thoughts,
his levels of depression and apathy have improved and the severity
of his OCD has lessened. “He is doing much better. He went from
compulsively calling the office daily to now checking in only during
his scheduled visits. He states that his mood is better and he has
been able to find joy in his life again.”
New Paradigm
Takacs said he’s glad to see the growth in the field of interventional psychiatry.
“It’s a whole new paradigm that’s been adopted. It’s very rare
to have a psychiatry department and a neurosurgery department
in sync where there’s an agreement that, on a carefully selected
subgroup of patients, invasive procedures are OK and helpful
and move both the patient’s lives and science forward. It is not
something that exists in very many places, not in the United States
and not worldwide.”
Williams said the strength of MUSC’s brain stimulation research
and lab is one reason MUSC is offering a new interventional
psychiatry fellowship. It is for residents and psychiatrists who want
to have an additional year of training in the wide variety of both
invasive and non-invasive brain stimulation technologies that now
are available, some of which have been pioneered at MUSC.
MUSC also has a curriculum within the residency program called
the interventional psychiatry track.
Attracted by a field that is fertile ground for the next leap in
what psychiatric treatment can offer, Williams said the interventional fellowship program will expose trainees to all the latest
brain stimulation technologies, teaching them how to use them so
they will be able to push the field forward and reach patients who
unfortunately have been unresponsive to traditional treatments.
“What we’re trying to say is that we still have a couch and a
prescription pad, but we have other types of technologies including brain stimulators that we’re using to treat various psychiatric
disorders. This is not to replace talk therapies or medications,
but it’s an augmentation for people who are not responding to
traditional treatments.”
For the rest of this story visit: http://academicdepartments.musc.edu/catalyst/archives/2014/6-13Brain.html
Medical University of South Carolina Neurosciences // neuronews
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News
Departmental Highlights
Congratulations to Philip Lee.
He was awarded the ABTA Medical
Student Summer Fellowship (MSSF)
from the American Brain Tumor Association. His project title is "Molecular
Mechanisms of Cell Death by which
DATS Regulates HDAC Activities and
ACetylation of Histone/Non-Histone
Proteins in Glioblastoma Cells."
Philip Lee
Congratulations to Kelly Kornegay, Epilepsy Inpatient Coordinator and Emma McCulloch, Clinical Unit Leader 9 West for
being selected as among the 7 Nurses of the Year for MUSC.
MUSC selected 7 nurses as Nurse of the Year based on the
values of the Nursing Practice Model. These values include
accountability, advocacy, collaboration, expertise, innovation,
integrity and leadership.
Kelly was selected for Advocacy and Emma for Leadership.
The nominees were selected by an online vote by the nursing
staff within MUSC. The Nurse of the Year for the other categories
are Accountability (Michelle Cooper), Collaboration (Madeline
Gehrig), Expertise (Melanie Ann Archer), Innovation (Savannah
Galloway), and Integrity (Kathy Kurowski).
Kelly and Emma were presented with their award at the 2014
Nursing Excellence Awards Ceremony held at St. Luke’s Chapel.
Gayle Wadford, Spine Center and Joint Replacement Program
Manager was the guest speaker. A reception was held immediately
following the ceremony in the Chapel Garden.
The 7 selected nurses for the MUSC Nurse of the Year award.
Photo from Strike out Stroke
On July 17, 2014, MUSC Students and Faculty went to the
Charleston Riverdogs Stadium for the annual “Stroke Out Stroke”.
According to MUSC faculty organizer Professor Daniel Lackland
DrPH, over a third of the attendees at the game have high blood
pressure. While most of the fans participating in Strike Out Stroke
are aware of their blood pressure levels, many do not know their
actual blood pressure values. Likewise, many have not maintained
contact with their healthcare provider and are not being treated
for hypertension. Data has shown that approximately 10% of
Strike Out Stroke participants will see a primary care provider
within one month of taking part in the program. This innovative
outreach and awareness program empowered over 150 patients to
take control of their health and reconnect with their local healthcare providers. In the process, students received training as they
educated fans on the connection between high blood pressure
and stroke and how we can all make a difference to “Strike Out
Stroke” in our communities.
Mr. and Mrs. Anderson thanked the NIR team for saving his
life. He changed his license plate to "miracle" because that is what
your team did! You and your team are miracle workers! Thank
you Imran Chaudry
for your sacrifices
and dedication to
becoming a life
changer! ~Christine
Holmstedt, M.D.
Photo of Mr. Anderson, Dr. Holmstedt and Mrs. Anderson
Medical University of South Carolina Neurosciences // neuronews
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News
Departmental Highlights
On July 1, 2014, Dr. Aljoeson Walker became Director of
the MUSC Comprehensive Multiple Sclerosis (MS) Program.
This program will provide a coordinated multidisciplinary approach to MS care, facilitating educational opportunities (e.g.
clinic rotations) for residents and medical students in MS, explore
opportunities for 'home-grown' translational research in MS,
develop a dedicated drug infusion center, run clinical trials in MS,
and systematically engage in outreach activities.
On July 1, 2014, Dr. Jonathan Halford became Director of
Industry and Patient Registry-Related Research for MUSC Clinical Neurosciences (Neurology and Neurosurgery). This position
which reports directly to Chairs of Neurology and Neurosurgery
will ensure that the organizational structure, staffing, infrastructure,
auditing functions, surveillance monitoring, and training needs, are
adequate to support the research enterprise for industry-funded
clinical trials and unfunded patient registry studies within MUSC
Clinical Neurosciences.
Congratulations to our neurology PGY-3 residents for securing prestigious fellowship positions for July 2015. Dr. Jessica
Hannah will be joining the MUSC Vascular Neurology Fellowship
program, and Dr. Karan Karwa will be going to the Neuromuscular Disease Fellowship program at the Cleveland Clinic.
Congratulations to our administrative assistant Tameka
Burgess for recently completing her Associates in Arts in Business Administration.
On July 1, 2014 Dr. Shelly Ozark took on the Directorship of
our Neurology Residency Program, Dr. Christina Vaughan will
be the Associate Residency Program Director. With both of these
terrific individuals at the helm, we anticipate ever-increasing success in all areas of the general neurology training program.
Residents Research Reunion Day, May 22, 2014, was a great
success. Our Neurology and Neurosurgery Residents did an
excellent job on their research and poster presentations. A special
congratulations goes to the award winners:
Libby Kosnik Infinger, M.D. - Best Overall Presentation
Karen Karwa, M.D. - Best Neurology Presentation
Jan Vargas, M.D. - Best Neurosurgery Presentation
Nolan Williams, M.D. - Most Promising New Research
(Neurology)
Avery Buchholz, M.D. - Most Promising New Research
(Neurosurgery)
Irfan Ali, M.D. - Best Case Report
Stephen Lowe, M.D. - Best Presentation by a Junior Resident
The first and second issues of our
Neurology Patient Newsletter entitled Brain
Buzz are ready. This newsletter will be a
quarterly brief update for our neurology
patients, each time providing them with information about happenings/progress within
a given neurology subspecialty at MUSC.
This first newsletter highlights our Comprehensive Epilepsy Center and the second the
Movement Disorders Program. It includes
recent developments in treatments for patients, ongoing clinical trials, patient stories
and promising technological advances. The
newsletters will be distributed in our outpatient clinic waiting areas,
posted permanently online, and potentially mailed out in a very
targeted fashion. To read the latest issue please visit:
www.musc.edu/neurosciences/news
Please visit the following link to view photos from the Resident
Research Reunion event, including images from the Robert J.
Adams Visiting Professorship guest lecture by Dr. Martin Samuels:
www.musc.edu/neurosciences/events/research_day
On May 15, 2014, the MUSC Board of Trustees approved the
partitioning of the Department of Neurosciences. July 1, 2014, the
new name of the clinical component became the Department
of Neurology and Neurosurgery (DNN), and the name of the
basic research component will be the Department of Neuroscience. DNN faculty will carry the title of Professor of Neurology or
Professor of Neurosurgery corresponding to their primary area of
expertise, emphasis or interest.
Tina Dvoren-Baker, NP and Suzanne Pach, NP recently
became Stroke Certified through the American Association of
Neurologic Nurses.
Congratulations to the Winners of the 2014 Annual Neurology Residency Program Awards:
Dr. Alison Smock - Excellence in Care
Dr. Nolan Williams - Resident Teacher of the Year
Dr. Dong In Sinn - Highest In-Service Score
Dr. Ken Nozaki - Faculty Teacher of the Year
Dr. Gonzalo Revuelta was recently awarded the SCTR
K12 Clinician Scientist award for his project: Identification of Gait
and Imaging Markers for Freezing of Gait in Parkinson’s Disease.
Congrats and well done!
Medical University of South Carolina Neurosciences // neuronews
6
News
Awards & Presentations
Appointments & Awards
Daniel Lackland: Chair of the MUSC College of Medicine
Appointments, Promotions and Tenure (APT) Committee
Daniel Lackland: Director of the MUSC Master of Science in
Clinical Research (MSCR) degree program
Wayne Feng: Member, American Stroke Association (ASA)
Rehabilitation and Recovery Committee
Bruce Ovbiagele: Member, Food and Drug Administration
(FDA) Peripheral and Central Nervous System Drugs Advisory
Committee
Bruce Ovbiagele: Vice Chair, International Stroke Conference (ISC) Program Committee
Bruce Ovbiagele: 11th Class of Liberty Fellows
The Liberty Fellows Program recruits diverse leaders, providing
them with a forum to reflect on what makes a just society, deepening their knowledge and perspectives and enhancing their capacity
to solve the problems facing leaders in South Carolina.
Congratulations to Dr. Marc Chimowitz for receiving the
MUSC Peggy Schachte Research Mentor Award. This award
recognizes individuals at MUSC who have excelled in mentoring faculty in obtaining research support from private and public
organizations or government agencies.
Ekrem Kutluay, Member, American Clinical Neurophysiology
Society (ACNS) Website and Social Media Committee
Ekrem Kutluay, Member, American Clinical Neurophysiology
Society (ACNS) Scientific Program Committee
Select Extramural Presentations
Tanya Turan
2014 ISACON in India
• Risk factor management in ICAD (3-15-14)
• MR imaging in intracranial atherosclerotic disease (3-16-14)
Marc Chimowitz
2014 ISACON in India
• EC-IC bypass in symptomatic ICA occlusion – What is the
current evidence? (3-14-14)
• CABG and Carotid stenosis – Which to treat first? (3-1414)
• Stenting versus medical management for ICAD-post
SAMMPRIS (3-15-15)
Robert Adams
8th Global Iron Summit March 14-16 in Greece
Neurological complications in SCD
Dan Lackland
2014 Chronic Disease Prevention Winter Symposium, March
7-8 in Myrtle Beach
• Prevention Strategies and the Decline in Stroke Risks: a
public health and clinical success story
• 2014 Treatment Guidelines from the JNC Appointed Panel
• Risk Assessment in the Management of Risk Factors
Vanessa Hinson
American Academy of Neurology Annual Meeting,
Philadelphia, PA
• Course Director “Clinical usefulness of Botulinum toxin and
treatment of dystonia”
• “Psychogenic movement disorders, epidemiology and
daphogenesis”
• “Psychogenic movement disorders, update of treatment”
Bruce Ovbiagele
American Academy of Neurology Annual Meeting,
Philadelphia, PA
• “Cerebrovascular Disease and Interventional Neurology:
Epidemiology/Risk Factors”
• “Cerebrovascular Disease and Interventional Neurology:
Rehabilitation, Recovery and Complications”
• Bruce Ovbiagele - 6th Annual New York State Stroke
Conference (sponsored by the New York State Department
of Health):
• Keynote: “The Aftermath of Acute Stroke: Not all
Prevention Programs are Created Equal”. New York, NY.
May 29, 2014
Medical University of South Carolina Neurosciences // neuronews
7
Publications
Featured Publications
Gass, J.T., Trantham-Davidson, H.,Kassab, A.S., Olive, M.F., & Chandler, L.J. Enhancement of extinction learning attenuates ethanolseeking behavior and alters plasticity within the addiction neurocircuitry. Journal of Neuroscience, 34(22), 7562-74. PMID24872560.
The Parkinson Study Group QE3 Investigators (including Hinson
VK). A Randomized Clinical trial of High-Dosage Coenzyme Q10
in Early Parkinson Disease: No Evidence of Benefit. JAMA Neurol.
2014 Mar 24.
Gass, J.T., Glen, W.B., McGonigal, J.T., Trantham-Davidson, H.,
Lopez, M., Randall, P.K., Yaxley, R., Floresco, S.B., & Chandler, L.J.
Adolescent alcohol exposure reduces behavioral flexibility, promotes
disinhibition, and increases resistance to extinction of ethanol selfadministration in adulthood. In Press: Neuropsychopharmacology.
PMID24820536.
Smith G, Wagner J, Andrews J, Austin J, Mueller M, Carter E, Griesemer K. Caregiving in pediatric epilepsy: Results of focus groups
and implications for research and practice. Epilepsy Behav. 2014 Mar
25;34C:34-41
Sergei A. Novgorodov, Christopher L. Riley, Jin Yu, Keith T. Borg,
Yusuf A. Hannun, Richard L. Proia, Mark S. Kindy, and Tatyana I.
Gudz. Essential Roles of Neutral Ceramidase and Sphingosine in
Mitochondrial Dysfunction Due to Traumatic Brain Injury. JBC The
Journal of Biological Chemistry. J.Biol. Chem. 2014, 289:13142-13154.
HBM-35-8-Cover1-Spine.qxp
7/4/14
Gonzalo J. Revuelta a,⁎, Jaime Montilla c, Michael Benatar b, Alan
Freemand, Thomas Wichmann d, Hyder A. Jinnah d, Mahlon R.
DeLong d, Stewart A. An 18F-FDG PET study of cervical muscle
in parkinsonian anterocollis. Factor. Journal of the Neurological Sciences 340 (2014) 174-177
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HUMAN BRAIN MAPPING
VOLUME 35, NUMBER 8, AUGUST 2014
View this journal online at wileyonlinelibrary.com
VOLUME 35, NUMBER 8, AUGUST 2014
Leonardo Bonilha, Ali Tabesh,
Kevin Dabbs, David A. Hsu, Carl
E. Stafstrom, Bruce P. Hermann
and Jack J. Lin. Neurodevelopmental alterations of large-scale
structural networks in children
with new-onset epilepsy. Human
Brain Mapping. 2014 August;
35(8): 3661-3672.
PAGES 3569– 4266
Chimowitz MI. Game changer
for endovascular treatment of
acute ischemic stroke? J Neurointerv Surg. 2014 Mar 12.
Sohn M, Culver DA, Judson MA, Scott TF, Tavee J, Nozaki K. Spinal
cord neurosarcoidosis. Am J Med Sci. 2014 Mar;347(3):195-8.
Park S, Nozaki K, Smith JA, Krause JS, Banik NL. Cross-talk between
IGF-1 and estrogen receptors attenuates intracellular changes in
ventral spinal cord 4.1 motoneuron cells because of interferon-gamma exposure. J Neurochem. 2014 Mar;128(6):904-18.
Heck CN, King-Stephens D, Massey AD, Nair DR, Jobst BC, Barkley
GL, Salanova V, Cole AJ, Smith MC, Gwinn RP, Skidmore C, Van
Ness PC, Bergey GK, Park YD, Miller I, Geller E, Rutecki PA, Zimmerman R, Spencer DC, Goldman A, Edwards JC, Leiphart JW,
Wharen RE, Fessler J, Fountain NB, Worrell GA, Gross RE, Eisenschenk S, Duckrow RB, Hirsch LJ, Bazil C, O'Donovan CA, Sun FT,
Courtney TA, Seale CG, Morrell MJ. Two-year seizure reduction in
adults with medically intractable partial onset epilepsy treated with
responsive neurostimulation: Final results of the RNS System Pivotal
trial. Epilepsia. 2014 Mar;55(3):432-41.
Towfighi A, Markovic D, Ovbiagele B. Consistency of Blood Pressure
Control After Ischemic Stroke: Prevalence and Prognosis. Stroke.
2014 Mar 27
Suzuki T, Voeks J, Zakai NA, Jenny NS, Brown TM, Safford MM,
LeWinter M, Howard G, Cushman M. Metabolic Syndrome, C-reactive Protein, and Mortality in U.S. Blacks and Whites: The Reasons for
Geographic and Racial Differences in Stroke (REGARDS) Study.
Diabetes Care. 2014 May 30.
Liebeskind DS, Kosinski AS,
Lynn MJ, Scalzo F, Fong AK, Fariborz P, Chimowitz MI, Feldmann
E. Noninvasive Fractional Flow on MRA Predicts Stroke Risk of
Intracranial Stenosis. J Neuroimaging. 2014 Mar 5.
Weber MA, Campbell NR, Lackland DT. The journal of clinical
hypertension has become the official journal of the world hypertension league. J Clin Hypertens (Greenwich). 2014 May;16(5):319. doi:
10.1111/jch.12338. Epub 2014 May 8.
Calhoun DA, Booth JN 3rd, Oparil S, Irvin MR, Shimbo D, Lackland
DT, Howard G, Safford MM, Muntner P. Refractory hypertension:
determination of prevalence, risk factors, and comorbidities in a
large, population-based cohort. Hypertension. 2014 Mar;63(3):451-8.
Lee CY, Tabesh A, Spampinato MV, Helpern JA, Jensen JH, Bonilha
L. Diffusional kurtosis imaging reveals a distinctive pattern of
microstructural alternations in idiopathic generalized epilepsy. Acta
Neurol Scand. 2014 May 3.
Bonilha L, Rorden C, Fridriksson J. Assessing the clinical effect of
residual cortical disconnection after ischemic strokes. Stroke. 2014
Apr;45(4):988-93.
Medical University of South Carolina Neurosciences // neuronews
8
Publications
Featured Publications Continued...
Revuelta GJ, Montilla J, Benatar M, Freeman A, Wichmann T, Jinnah
HA, Delong MR4, Factor SA. An (18)F-FDG PET study of cervical
muscle in parkinsonian anterocollis. J Neurol Sci. 2014 May 15;340(12):174-7.
Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI,
Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, Johnston
SC, Kasner SE, Kittner SJ, Mitchell PH, Rich MW, Richardson D,
Schwamm LH, Wilson JA; on behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing,
Council on Clinical Cardiology, and Council on Peripheral Vascular
Disease. Guidelines for the Prevention of Stroke in Patients With
Stroke and Transient Ischemic Attack: A Guideline for Healthcare
Professionals From the American Heart Association/American
Stroke Association. Stroke. 2014 May 1.
Ovbiagele B, Reeves MJ, Nasiri M, Johnston SC, Bath PM, Saposnik G; for the VISTA-Acute Collaboration Steering Committee. A
Simple Risk Index and Thrombolytic Treatment Response in Acute
Ischemic Stroke. JAMA Neurol. 2014 May 5.
Owolabi MO, Ovbiagele B. Global clinical neuroscience: Journey of
a thousand miles begins with a single step. J Neurol Sci. 2014 Jun 17.
Ellis C, McGrattan K, Mauldin P, Ovbiagele B. Costs of pediatric
stroke care in the United States: a systematic and contemporary
review. Expert Rev Pharmacoecon Outcomes Res. 2014 Jun 26:1-8.
Ovbiagele B, Schwamm LH, Smith EE, Grau-Sepulveda MV, Saver
JL, Bhatt DL, Hernandez AF, Peterson ED, Fonarow GC. Patterns
of care quality and prognosis among hospitalized ischemic stroke
patients with chronic kidney disease. J Am Heart Assoc. 2014 Jun
5;3(3).
Turk AS, Turner R, Spiotta A, Vargas J, Holmstedt C, Ozark S,
Chalela J, Turan T, Adams R, Jauch EC, Battenhouse H, Whitsitt
B, Wain M, Chaudry MI. Comparison of endovascular treatment
approaches for acute ischemic stroke: cost effectiveness, technical
success, and clinical outcomes. J Neurointerv Surg. 2014 Jul 15. pii:
neurintsurg-2014-011282.
Saposnik G, Ovbiagele B, Raptis S, Fisher M, Johnston SC. Effect of
english proficiency and research funding on acceptance of submitted articles to stroke journal. Stroke. 2014;45(6):1862-8.
López-Cancio E, Matheus MG, Romano JG, Liebeskind DS, Prabhakaran S, Turan TN, Cotsonis GA, Lynn MJ, Rumboldt Z, Chimowitz
MI. Infarct Patterns, Collaterals and Likely Causative Mechanisms of
Stroke in Symptomatic Intracranial Atherosclerosis. Cerebrovasc Dis.
2014 Jul 4;37(6):417-422.
Owolabi MO, Mensah GA, Kimmel PL, Adu D, Ramsay M, Waddy
SP, Ovbiagele B, Rabada-Diehl C, Rasooly R, Akarolo-Anthony SN,
Rotimi C; H3Africa Consortium. Understanding the rise in cardiovascular diseases in Africa: harmonising H3Africa genomic epidemiological teams and tools. Cardiovasc J Afr. 2014 May 26;25:1-4.
Boan AD, Lackland DT, Ovbiagele B. Lowering of Blood Pressure for Recurrent Stroke Prevention. Stroke. 2014 Jul 1. pii:
STROKEAHA.114.003666. [Epub ahead of print]
Lackland DT. Racial Differences in Hypertension: Implications for
High Blood Pressure Management. Am J Med Sci. 2014 Jun 30.
Irvin MR, Booth JN 3rd, Shimbo D, Lackland DT, Oparil S, Howard G,
Safford MM, Muntner P, Calhoun DA. Apparent treatment-resistant
hypertension and risk for stroke, coronary heart disease, and allcause mortality. J Am Soc Hypertens. 2014 Jun;8(6):405-13.
Helton KJ, Adams RJ, Kesler KL, Lockhart A, Aygun B, Driscoll C,
Heeney MM, Jackson SM, Krishnamurti L, Miller ST, Sarnaik SA,
Schultz WH, Ware RE. Magnetic resonance imaging/angiography
and transcranial Doppler velocities in sickle cell anemia: results from
the SWiTCH trial. Blood. 2014 Jun 9.
Sposato LA, Ovbiagele B, Johnston SC, Fisher M, Saposnik G. A
peek behind the curtain: Peer review and editorial decision-making in
STROKE. Ann Neurol. 2014 Jul 4. [Epub ahead of print]
Owolabi MO, Akinyemi RO, Gebregziabher M, Olaniyan O, Salako
BL, Arulogun O, Ovbiagele B. Randomized controlled trial of a
multipronged intervention to improve blood pressure control among
stroke survivors in Nigeria. Int J Stroke. 2014 Jul 18. [Epub ahead of
print]
Ellis C, Hyacinth HI, Beckett J, Feng W, Chimowitz M, Ovbiagele B,
Lackland D, Adams R. Racial/Ethnic differences in poststroke rehabilitation outcomes. Stroke Res Treat. 2014;2014:950746.
Boan AD, Feng WW, Ovbiagele B, Bachman DL, Ellis C, Adams RJ,
Kautz SA, Lackland DT. Persistent racial disparity in stroke hospitalization and economic impact in young adults in the buckle of stroke
belt. Stroke. 2014;45(7):1932-8.
Medical University of South Carolina Neurosciences // neuronews
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Alumni
Alumni Profiles
Kimberly N Hutchison, M.D. MUSC Neurology Residency, 2000-2004
Dr. Kim Hutchison attended Colorado College and the School of Medicine at the University of Kansas prior to her neurology residency at
MUSC, where she served as Chief Resident. She completed a fellowship in sleep medicine at Vanderbilt University, and she joined the Vanderbilt
faculty immediately after her fellowship.
She and her husband, Ryan, a family medicine physician, moved with their family to Saipan of the Northern Mariana Islands, where she
established a sleep medicine program. She is now Assistant Professor of Neurology at Oregon Health Sciences University in Portland.
Dr. Hutchison’s clinical interests include general neurology and sleep medicine. She
is heavily invested in teaching fellows, residents, and medical students. She leads the
department’s efforts in teleneurology and continues to follow her patients in Saipan
through that medium. Her research interests include the study of sleep deprivation
through fMRI and care delivery systems.
Dr. Hutchison and her family enjoy the great outdoors in the Pacific Northwest,
including white water rafting, fishing, and hiking. She emphasized her quest for work/
life balance and her success in doing so: “it can be done!”
Looking back to her days at MUSC, she continues to cherish the close relationship
between residents and attendings during her training. She cited the special place
in her heart for Olivia Burch, whom she characterized as a “loving mama bear,” high
praise indeed. She recalls fondly dinner at attendings’ homes, Dr. Aljoeson Walker’s tips on the management of headaches, and the beautiful
backdrop of Charleston. She extended an invitation for residents to consider training at the superb, multi-disciplinary sleep program at Oregon
Health Sciences University.
R. Norman Harden, M.D. MUSC Neurology Residency, ’84-88
Dr. R. Norman Harden holds the Robert G Addison Chair in Pain Studies at the Rehabilitation Institute of
Chicago, where he is Director at the Center for Pain Studies. He is also Professor in the Department of Physical
Medicine and Rehabilitation and the Department of Physical Therapy and Human Movement Sciences at
Northwestern University.
Dr. Harden came to MUSC after he earned his M.D. degree at the Medical College of Georgia, and he attended
undergraduate school at Emory University. During residency he developed clinical and research interests in pain,
leading him to a fellowship in pain studies at the Pain Control and Rehabilitation Institute of Georgia in Atlanta.
He has pursued his academic career at the Rehabilitation Institute of Chicago and at Northwestern University. His clinical interests include
painful neurological and somatic disorders, including complex regional pain syndrome and myofascial pain. He is chair of the Clinical Affairs
Committee of the Reflex Sympathetic Dystrophy Association and serves on the editorial boards of the Journal of Neuropathic Pain, the Clinical
Journal of Pain, Current Pain and Headache Reports, and the Journal of Back and Musculoskeletal Rehabilitation.
As leisure activity, Dr. Harden’s interest in music extends back to his days at MUSC, and he still considers himself “a rock and roll musician!” He
also enjoys gardening and sailing. Asked to reflect on his residency days at MUSC, he replied, “why did I ever leave!”
For more Alumni News please visit:
www.musc.edu/neurosciences/alumni
Medical University of South Carolina Neurosciences // neuronews
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Academics
Academic Updates - Welcome New Residents & Fellows
Neurology Residency - PGY Level 5
(left to right)
Royland Hamilton, M.D.
Clinical Neurophysiology
Devanshi Mody, M.D.
Clinical Neurophysiology
Lina Rodriguez Rosario, M.D.
Clinical Neurophysiology
Alison P. Smock, M.D.
Vascular Neurology
Neurology Residency - PGY Level 1
(left to right)
Kumaraswamy Guttalu, M.D., Ph.D.
Gabriel Bonnell, M.D.
Laura Juul, M.D.
Ashley Rawls, M.D.
Danuel Snelgrove, M.D.
Psychiatry/Neurology - PGY Level 1
Pediatric Neurology Residency - PGY Level 1
Joshua Brown, M.D., Ph.D.
Pooja Patel, D.O.
Neurosurgery Residency - PGY Level 1
(left to right)
Fraser Henderson, M.D.
Luis "Rick" Liogier-Weyback, M.D.
Medical University of South Carolina Neurosciences // neuronews
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Academics
Academic Updates - Recent Graduates
Roland T. Hamilton, Jr., M.D.
A recent graduate of the MUSC
Neurology Residency Program, he will
continue on at MUSC as a Clinical
Neurophysiology Fellow.
Alison Smock, M.D.
A recent graduate of the MUSC
Neurology Residency Program, she will
continue on at MUSC as a Vascular
Neurology Fellow.
Nolan Williams, M.D.
A recent graduate of the MUSC
Neurology Residency Program, he
will continue on as an Instructor in
Psychiatry at Stanford University.
Erin Ilkanich Sparks, M.D.
A recent graduate of the MUSC
Neurology Residency Program, she will
continue on in private practice.
Amandeep Kalra, M.D.
A recent graduate of the MUSC
Neurology Residency Program, he
will continue on as a Neuro-oncology
Fellow at Memorial Sloan Kettering
Cancer Center.
Wenyu "Andy" Sun, M.D., MPH
A recent graduate of the MUSC
Neurology Residency Program, he will
continue on in private practice.
Libby Kosnik Infinger, M.D., MPH,
A recent graduate of the MUSC
Neurosurgery Program, she will continue
on as a fellow at Cincinnati Hospital.
Medical University of South Carolina Neurosciences // neuronews
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Employee Update
Academic Updates - Welcome International Fellows
Hyung-Min Kwon, M.D., Ph.D.
Department of Neurology
Seoul National University Boramae Medical Center
Republic of Korea
Collaborating with Dr. Chimowitz in the Stroke Program.
Burak Pakoz, M.D.
Department of Neurology
Kent Hospital
Izmir, Turkey
Collaborating with Dr. Kutluay in the Epilepsy Division.
Employee Updates
Welcome New Employees
Ramin Eskandari, M.D.
Catrina Robinson, Ph.D.
David G. Clark, M.D.
Nicholas Milano, M.D.
Katherine Ruzhansky, M.D.
Joseph Krainin, M.D.
Ashley Jolliff
Becky Hamrick
Todd LeMatty
Cody Laverdiere
Jerri O’Banner
Julia Debenham
Charles Andrews, M.D.
Heather Norton, SCNP-BC
Shanna Amoroso, MSN, CRNP
Medical University of South Carolina Neurosciences // neuronews
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employee Update
Employee Spotlight:
Dondra Rodd
Meet employee Dondra Rodd. Dondra has been with MUSC for
fourteen years. She currently works as administrative specialist for Drs.
Mimi Sohn and Aljoeson Walker. Recently, Dondra was selected as
the recipient of the 2014 Neurology Administrator Staff Member of
the Year Award. Comments regarding Dondra’s performance include,
“She is reported by the patients to be therapeutic and comforting in her
conversations…described as a clear bright jewel in the department.” “We
are fortunate to have a caring, effective co-worker” “She is always very
professional and polite to everyone. She maintains her sense of humor and
provides encouragement to her co-workers. She is a role model for grace
under pressure and dedicated to getting everything that her patients need”.
TELL US MORE!
Where are you originally from, and can you tell us a fun fact
about the city?
I am originally from Charleston. Charleston calls itself the
Holy City because of the many places we have to worship.
What do you like to do in your free time?
Spend time with family and friends, read
What one food do you wish had zero calories?
I wish cake/cupcakes had zero calories.
WORK
How are you changing what's possible?
I collaborate with Kathryn Meltzer, PA-C, Mimi Sohn, M.D.,
and Aljoeson Walker, M.D. to provide excellent and innovative
healthcare to our patients.
What do you enjoy most about your job at MUSC?
Helping the patients and learning more about Multiple
Sclerosis.
When you were little, what did you want to be when you
grew up?
I always wanted to be a teacher.
What would you like to be famous for?
I would like to famous for giving back to the youth at church
and my community, and who knows possibly globally.
Medical University of South Carolina Neurosciences // neuronews
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Employee Update & Social News
starting from top left (going clockwise)
MUSC Students and Faculty at the Charleston RiverDogs Stadium participate at the annual “Stroke Out Stroke" · Dr.
Ryan Kellogg and Dr. Jan Vargas at Residents Research Reunion Day · Strike out Stroke blood pressure monitoring
station
· Dr. Libby Kosnik Infingers graduation dinner · Recent graduates of the Neurology Residency Program · Dr.
Robert Adams and guest speaker Dr. Martin Samuels from Residents Research Reunion Day
Medical University of South Carolina Neurosciences // neuronews
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clinical Trials
Clinical Trials
Clinical trials, also called research studies, are managed by government agencies, educational institutions, private not-for-profit organizations, or commercial businesses, to develop, produce, and evaluate the effectiveness of new treatments and therapies for diseases. New
trials are added on a routine basis, and many clinical trials accept only a limited number of participants. The following is a list of TRU clinical
trials that are actively enrolling patients.
If you are interested in viewing additional clinical trials, not included in the list below, please visit the site links below:
South Carolina Clinical Trials - http://scresearch.org/
MUSC Hollings Cancer Center Clinical Trials - http://prc.hcc.musc.edu/portal/cto/ClinicalTrials/tabid/488/Default.aspx
NEURO-ONCOLOGY:
A Phase II Clinical Trial Evaluating DCVax-Brain,
Autologous Dendritic Cells (DC) Pulsed with Tumor
Lysate Antigen for the Treatment for Glioblastoma
Investigator: Scott Lindhorst, M.D.
Coordinator: Michele DeCandio, RN, OCN, CCRP Contact: 843-792-9016, decandio@musc.edu
An International, Randomized, Double-Blind, Controlled
Study of Rindopepimut/GM-CSF with Adjuvant TMZ
in Patients with Newly Diagnosed, Surgically Resected
EGFRvIII-positive Glioblastoma
Investigator: Bruce Frankel, M.D.
Coordinator: Michele DeCandio, RN, OCN, CCRP Contact: 843-792-9016, decandio@musc.edu
A Phase I-II Trial of Everolimus and Sorafenib in Patients
with Recurrent High-Grade Gliomas
Investigator: Scott Lindhorst, M.D.
Coordinator: Michele DeCandio, RN, OCN, CCRP Contact: 843-792-9016, decandio@musc.edu
Randomized, Double-Blind, Placebo-Controlled Trial
of Lacosamide for Seizure Prophylaxis in Patients with
High-Grade Gliomas
Investigator: Scott Lindhorst, M.D.
Coordinator: Michele DeCandio, RN, OCN, CCRP Contact: 843-792-9016, decandio@musc.edu
Phase III Intergroup Study of Temozolomide Alone
Versus Radiotherapy with Concomitant and Adjuvant
Temozolomide Versus Radiotherapy with Adjuvant PCV
Chemotherapy in Patients 1p/19q Co-Deleted Anaplastic
Glioma
Investigator: Scott Lindhorst, M.D.
Coordinator: Bo Keller, CCRP
Contact: 843-792-1286, kellej@musc.edu
Phase III Trial on Concurrent and Adjuvant
Temozolomide Chemotherapy in Non-1p/19q Deleted
Anaplastic Glioma: The CATNON Intergroup Trial
Investigator: Scott Lindhorst, M.D.
Coordinator: Bo Keller, CCRP
Contact: 843-792-1286, kellej@musc.edu
Imaging Biomarkers of Tissue Miscrostructure and
Vasculature as Predictors of Glioblastoma Multiforme
Response to Treatment with Bevacizumab for Progressive
Disease
Investigator: Scott Lindhorst, M.D.
Coordinator: Bo Keller, CCRP
Contact: 843-792-1286, kellej@musc.edu
Phase I/II Adaptive Randomized Trial of Bevacizumab
Versus Bevacizumab plus Vorinostat in Adults with Recurrent Glioblastoma
Investigator: Scott Lindhorst, M.D.
Coordinator: Bo Keller, CCRP
Contact: 843-792-1286, kellej@musc.edu
Phase II Trial of Oral Pazopanib Plus Oral Topotecan
Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab
Exposure and (B) After Failing Prior Bevacizumab
Investigator: Scott Lindhorst, M.D.
Coordinator: Bo Keller, CCRP
Contact: 843-792-1286, kellej@musc.edu
APHASIA
Transcranial Direct Current Stimulation and Aphasia
Treatment Outcomes
Investigator: David Bachman, M.D.
Coordinator: Sheri Davis
Contact: 843-792-2845, davshe@musc.edu
Medical University of South Carolina Neurosciences // neuronews
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clinical Trials
MOVEMENT DISORDERS:
EPILEPSY:
Creatine Safety, Tolerability & Efficacy in Huntington’s
Disease (CREST-E)
Investigator: Gonzalo Revuelta, M.D.
Coordinator: Shonna Jenkins, MS
Contact: 843-792-9115, jenkinsho@musc.edu
The Human Epilepsy Project
Investigator: Jonathan Halford, M.D.
Coordinator: Sheri Davis
Contact: 843-792-3855, schnabel@musc.edu
A Clinical Study of Patients with Symptomatic
Neurogenic Orhtostatic Hypotension to Assess
Sustained Effects of droXidopa Therapy (PHOENIX)
Investigator: Gonzalo Revuelta, M.D.
Coordinator: Shonna Jenkins, MS
Contact: 843-792-9115, jenkinsho@musc.edu
A Phase 3, 12-Week, Double-Blind, Placebo-Controlled,
Randomized, Multicenter Study to Evaluate the Efficacy
of Oral Istradefylline 20 and 40mg/day as Treatment for
Subjects with Moderate to Severe Parkinson’s Disease
Investigator: Christina Vaughan, M.D.
Coordinator: Shonna Jenkins, MS
Contact: 843-792-9115, jenkinsho@musc.edu
Atomoxetine Treatment for Cognitive Impairment in
Parkinson’s Disease
Investigator: Vanessa Hinson, M.D.
Coordinator: Shonna Jenkins, MS
Contact: 843-792-9115, jenkinsho@musc.edu
A Randomized, Double-Blind, Placebo-Controlled Study
of SD-809 (Dutetrabenazine) for the Treatment of
Moderate to Severe Tardive Dyskinesia
SD-809-C-20 (Pro00035069)
Investigator: Christina Vaughan, M.D.
Coordinator: Shonna Jenkins, MS
Contact: 843-792-9115, jenkinsho@musc.edu
An Open-Label, Long-Term Safety Study of SD-809
(Dutetrabenazine) for the Treatment of Moderate to
Severe Tardive Dyskinesia
Investigator: Christina Vaughan, M.D.
Coordinator: Shonna Jenkins, MS
Contact: 843-792-9115, jenkinsho@musc.edu
A Pivotal, Phase III Trial of Detecting Generalized TonicClonic Seizures with a Seizure Detection and Warning
System in Epilepsy Patients
Investigator: Jonathan Halford, M.D.
Coordinator: Sheri Davis Contact: 843-792-3855, schnabel@musc.edu
fMRI in Anterior Temporal Epilepsy Surgery
Investigator: Leo Bonhila, M.D.
Coordinator: Sheri Davis
Contact: 843-792-2845, davshe@musc.edu
Location of Seizures with Post Ictal MRI
Investigator: Leo Bonhila, M.D.
Coordinator: Sheri Davis
Contact: 843-792-2845, davshe@musc.edu
Histological Analysis Epilepsy Surgery Tissue
Investigator: Leo Bonhila, M.D.
Coordinator: Sheri Davis
Contact: 843-792-2845, davshe@musc.edu
Advance Brain Imaging
Investigator: Leo Bonhila, M.D.
Coordinator: Sheri Davis
Contact: 843-792-2845, davshe@musc.edu
Neuropsychological Evaluation During Routine
Intracranial Recording
Investigator: Leo Bonhila, M.D.
Coordinator: Sheri Davis
Contact: 843-792-2845, davshe@musc.edu
SPINE:
A Double-Blind, Placebo-Controlled Study of AC105 in
Patients with Acute Traumatic Spinal Cord Injury
Investigator: Abhay Varma, M.D.
Coordinator: Angela Robinson
Contact: 843-792-7118, robia@musc.edu
A Prospective, Post-Market Assessment of Nanoss
Bioactive 3D in the Posterolateral Spine
Clinical trials
are the primary way
breakthroughs
in treating diseases are made.
Investigator: Abhay Varma, M.D.
Coordinator: Angela Robinson
Contact: 843-792-7118, robia@musc.edu
An Observational, Multi-Center, Non-Randomized
(Single Arm) Registration of the PerX360 System
Investigator: Stephen Kalhorn, M.D.
Coordinator: Angela Robinson
Contact: 843-792-7118, robia@musc.edu
Medical University of South Carolina Neurosciences // neuronews
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Grants (March - May 2014)
PI
March 2013
Chimowitz, M
Voeks, J
April 2014
Lindhorst, S
May 2014
Ovbiagele, B
Revuelta, G
Turan, T
Title ; Age ncy
Total
SmartState Stroke Countess Paolozzi Endowed Chair MUSC Fdn. (016318)
$93,661
Carotid Revascularization Endarterectomy vs. Stenting Trial: Long Term Follow-up $89,127
Rutgers University R01NS038384/Index #107881 (016500)
An Open-Label, Randomized, Phase 3 Trial of Nivolumab versus Investigator's
Choice Chemotherapy as First-Line Therapy for Stave IV or Recurrent PF-L1+
Non-Small Cell Lung Cancer Bristol Myers Squibb CA209-143-0023 (018287)
$199,449
Tailored Hospital-Based Risk Reduction to Impede Vascular Events after Stroke
$509,099
NIH/NINDS 5U01NS079179-04 (017411)
$176,955
An Open-Label, Long-Gterm Safety Study of SD-809 (Dutetrabenazine) For
the Treatment of Moderate to Severe Tardive Dyskinesia - Protocol Number:SD809-C-20 INNO Clinical Outcomes, LLC SD-809-C-18 (018312)
Characterization of Intracranial Atherosclerotic Stenosis Using HR MRI
$186,105
NIH/NINDS 5K23NS069668-04 (016700)
Thank you for your contributions.
For questions, comments or to make a submission please email:
vought@musc.edu
www.musc.edu/neurosciences
© 2014 Medical University of South Carolina. All rights reserved.
Medical University of South Carolina Neurosciences