Profession
nal Educatioon Unit
MO
OREHEAD STATE
S
UN
NIVERSITY
Y
PRO
OFESSIONA
AL EDUCA
ATION UNIT
T
COLLEG
GE OF SCIE
ENCE AND TECHNOL
LOGY
DEPARTM
MENT OF BIOLOGY
B
A
AND CHEMISTRY
BIIOLOGY 38
80 – CELL B
BIOLOGY
DELIVERY
D
METHOD
M
– TRADITIO
ONAL CLAS
SSROOM
COURSE SY
YLLABUS – Fall 2012
COU
URSE: BIOL
L 380. Cell Biology
B
(2-2
2-3) I, II.
TIM
ME AND PLA
ACE: Lect. 3:00 – 5:10
0 T in Lappin 311;
Lab. 1:50-4:00 M (lab sectio
on1) or 1:50--4:00 W (lab
b section 2) iin Lappin 3441
LEC
CTURE PRO
OFESSOR:
LAB
B PROFESSO
OR:
OFF
FICE:
PHO
ONE:
EMA
AIL:
OFF
FICE HOURS:
David J. Saxon,
S
Ph.D.
David J. Saxon,
S
Ph.D.
301C Lapp
pin Hall
783-2295
d.saxon@m
moreheadstaate.edu
See last paage of docum
ment (Facultyy Schedule)
COU
URSE DESC
CRIPTION: Integration
I
off biological, chemical,
c
andd physical asppects of the ceell. Emphasis on molecularr
proceesses. Prereq
quisites: BIOL
L 304, and CH
HEM 201 or CHEM
C
326.
Requ
uired Field Experiencee Hours: [ 0 ]
“Com
mmunity Eng
gagement: A Light to aand from thee Mountainss”
Professional Education Unit at Morrehead State University ddelivers rigoorous, high qquality progrrams that
The P
preppare professiionals inform
med by best national
n
and
d internationnal scholarshhip, plus reseearch, literaature, and
expeeriences speccific to Appa
alachia- prep
paring profe
fessionals to improve thee schools, quality of life, and the
comm
munities in which
w
they liive and servee. This statem
ment is not oonly the straategic missioon for the Coollege, but it
also incorporatees the concep
ptual framew
work that guiides all our aactivities.
amework Ou
utcomes (CF
FO’s):
Conceptual Fra
The Unit and thee faculty within individu
ual programss assess the ddegree to whhich its graduuates:
1) M
Master the content knowledge, professsional and th
he twenty – first centuryy skills need to make an optimal
contrribution to “whole”
“
stud
dent learning
g in education settings.
Are competen
nt in the colleection and use
u of data to
o inform decision – makiing and to deemonstrate
2) A
accoountability fo
or student leaarning.
Demonstrate professional
p
l dispositionss
3) D
4) Are culturally competent and understand the regions from which they have come utilizing knowledge and
experiences to effectively “bridge the gaps” (economic, achievement, and geographic) ensuring optimal
learning for all students.
5) Engage in authentic field experiences in collaboration with committed school – based partners and are
empowered to improve the quality of education throughout this region and beyond.
COURSE GOALS: The purpose of the course is to concentrate on the molecular concepts by which cells, mainly
eukaryotic cells, function. A basic theme is the development of an understanding of how to investigate cellular
activities/functions (scientific method/inquiry-based learning), which is applied to understanding molecular
functions, which is applied to develop an understanding of the mechanisms of cellular activities/functions. This
theme of inquiry-based-learning and constructivist philosophy emphasizes that learning is an active process. To
be academically successful in the course each student must exhibit positive dispositions, by coming to class well
prepared and skillfully managing available resources.
STUDENT LEARNER OUTCOMES:
Students will be expected to:
1. use thinking, writing, and mathematical skills to evaluate interpret, and solve problems related to
cell biology;
2. use their understanding of molecular and cellular activity to evaluate what they read and observe
in regard to health, the environment, and other cellular related issues;
3. use their understanding of cellular investigations to interpret information and solve biological
problems;
4. and use their understanding of biomolecular chemical process to explain the properties/activities
molecular mechanisms of heredity, control of gene expression, membrane systems, energy
conversion, cytoskeleton, cell movement, cell growth mechanisms, and cell signaling, that are
common to cells.
NCATE/ EPSB Accreditation Alignment of CFO’s and SLO’s:
Program:
[ Biology - teaching ]
Aligned with
Kentucky
Teacher
Standards
(KTS)
Assessment
(point values)
lecture and lab
exams (400)
CFO:1, 2
SLO: 1, 2, 3, 4
Lecture and lab
quizzes (100)
CFO: 1, 2
SLO: 1, 2, 3, 4
Lab reports (15)
CFO: 1, 2
SLO: 2, 3, 4
[Cell Biology BIOL 380]
KERA
Initiatives
Education
Professional
Standards
Board
(EPSB)
National
Science
Teachers
Association
(NSTA)
1,
2,5
Literacy
1, 2
1
2, 5
Literacy
1,2
1
1, 5
Literacy
1,3
Assignment Descriptions:
Program: BIOLOGY – SECONDARY TEACHING
Assessment (point value)
Cell Biology (BIOL 380)
Description
Lecture and Lab exams
(400)
Exams will assess content knowledge and conceptual
understanding of the course material from lecture and the
laboratory. Problem solving/critical thinking skills required.
Exams will be given during scheduled class time.
Lecture and Lab quizzes
(100)
Lecture quizzes will assess content knowledge and
conceptual understanding of the course material from lecture
and the laboratory. Problem solving/critical thinking skills
required. Quizzes will be given during scheduled class time.
Lab reports (15)
Lab reports will be assessed in regard to appropriateness of
title, hypothesis, data presentation and conclusion.
Materials and procedures are a part of the lab experiment
handouts and are not required in the reports. The reports are
due at beginning of the next class meeting.
GRADING POLICY: Grades will be assigned on a % basis of 515 points.
Exam I
100pts
Exam II
100pts
Exam III
100pts
Comprehensive Final Exam 100pts
Quiz Average
100pts
Lab reports
15pts
515pts
GRADING SCALE: A = 90-100%
B = 80-89%
C = 70-79%
D = 60-69%
E ≤ 59%
Required Textbooks:
REQUIRED TEXT: Essential Cell Biology, 3rd edition, by B. Alberts, D. Bray, K. Hopkin, A. Johnson,
J. Lewis, M. Raff, K. Roberts and P. Walter. Garland Publish., Inc., N.Y., 2010.
ISBN: 978-0-8153-4129-1
COURSE EVALUATION: Course Activities - Students will be asked to listen, think and interact with the
teacher in regard to course material presentations given by the teacher, take quizzes and exams which require
thinking and writing skills, read assigned materials, and interact with classmates to develop answers to
questions/solve problems/conduct laboratory experiments. Students will use mathematical skills, computer
technology, and laboratory methods to study cell functions. Students will also be asked to formulate hypotheses,
present results and draw conclusions in regard to laboratory investigations (including preparation of lab reports) of
cell functions. Lab and lecture material may be present on exams and quizzes. Students should be prepared for
quizzes (10 pts each) given at the beginning of each class period, except on the day of exams. Written work on
exams and quizzes will include assessment of critical thinking/problem-solving skills. Students must be prepared to
address a question, using appropriate vocabulary and explanations which focus on the “how” and “why”
components which are relative to the question. Tutor/review sessions will be announced.
ATTENDANCE POLICY: Since classes are scheduled it is evident that attendance is important. Students are
expected to attend all scheduled meetings of the class. Laboratory exercises which are missed may not be made-up.
If a student is absent the professor must be notified (e-mail preferred) within 24 hours (before the absence if
possible) of the absence to be eligible for any options (determined by the professor) available to the student in
regard to make-up of quizzes or exams. Consistent tardiness is not acceptable.
CLASSROOM PROTOCOL:
Academic dishonesty may result in failure of the class. Note the section in the syllabus on academic honesty.
Cell Phones (including Blackberry’s and I phones), Walkie Talkie’s, PDA’s, and Beepers must be shut off upon
entering the classroom. MP3 Players, iPOD’s or any other device requiring the use of headphones are not
permitted during class.
Laptops and Tape recorders are permitted. It is a safety issue to have power cords running across the floor (It is
your responsibility to have a fully charged battery). If you are discovered doing anything other than course
related material on your laptop during class you may be asked to leave the class immediately and you will lose
your privilege to bring your laptop to class.
Academic Honesty
Academic dishonesty may result in failure of the class. Cheating, fabrication, plagiarism or helping others to
commit these acts will not be tolerated. Academic dishonesty will result in severe disciplinary action including,
but not limited to, failure of the student assessment item or course, and/ or dismissal from MSU. If you are not
sure what constitutes academic dishonesty, read the Eagle: Student Handbook or ask your instructor. An
example of plagiarism is copying information from the internet when appropriate credit is not given. The policy
is located at http://morehead-st.edu/units/studentlife/handbook/academicdishonesty.html
Americans with Disabilities Act (ADA)
In compliance with the ADA, all students with a documented disability are entitled to reasonable
accommodations and services to support their academic success and safety. Though a request for services may
be made at any time, services are best applied when they are requested at or before the start of the semester. To
receive accommodations and services the student should immediately contact the Disability Services
Coordinator in the Office of Academic and Career Services, 204E Allie Young Hall, 606-783-5188, or
e.day@moreheadstate.edu Any student with a validated accommodation for a validated disability should make
an appointment to see me as soon as possible.
Campus Safety Statement
Emergency response information will be discussed in class. Students should familiarize themselves with the
nearest exit routes in the event evacuation becomes necessary. You should notify your instructor at the
beginning of the semester if you have special needs or will require assistance during an emergency evacuation.
Students should familiarize themselves with emergency response protocols at
http://www.moreheadstate.edu/emergency
USE OF TECHNOLOGY: Students will be expected to use the internet, MSU e-mail, word processing, and
any other appropriate technology (including Blackboard) needed to complete assignments. Blackboard and
MSU email will be used to dispense course materials to students.
e-MAIL: ONLY MSU e-mail is to be used for all e-mail communications between student and professor.
Course Calendar: BIOL 380-1 (Cell Biology)
Fall 2012 Tentative Daily Schedule
Course Content: (note each period = 2 hours)
NOTE: Any changes in the syllabus will be announced by the professor.
Period
Topic(s)
1
Introduction, the nature of biological inquiry (questions addressed, hypothesis,
experimental design, results, & conclusion) & relation of statistics to hypothesis testing (Ho: vs Ha).
Research article assignment. Introduction to cells (chapter 1) – cell theory, cell biology discoveries
(Nobel laureate web site), fractionation of cells (chapter 4)
2
Laboratory: The Microscope, Calibration of Ocular Micrometer and Examination &
Measurement of Selected Cells
3
Analysis of assigned research article. Significance of Biomolecules (chapters 2,3,4) Proteins
(including enzymes/isoenzymes, Ig, & Hb), binding affinities and regulation
4
Laboratory: Influence of pH on the Specific Activity of Yeast G6P-Dehydrogenase
5
Biomolecules continued - Selected carbohydrate, lipid, & nucleotide molecular characteristics &
functions
6
Laboratory: Genetic Transformation & Electrophoresis (SDS-PAGE) of GFP
7
Membrane Structure and Function (chapters 11,12, 20) – including cellular junctions
8
Laboratory: Membrane Permeability
9
Exam I
10
Cell signaling (chapters 12, 16) – Strategies of chemical signaling (endocrine, intracrine, paracrine,
autocrine) with selected signal ligands, receptors, transduction & amplification, & effectors
11
Laboratory: Lectins and Cell Surface Receptors
12
Cell signaling continued – including neural signaling
13
Laboratory: Comparison of IgG Binding Using ELISA
14
Molecular Nature of the Chromosome and Gene (chapters 5,6,7,8): DNA & the
Chromosome. Central Dogma of Molecular Biology – replication & high fidelity, the gene,
applications relative to understanding this central dogma (HIV, antibiotics, chemotherapy, Humulin)
15
Laboratory: Development of the Immune System & Western Blotting
16
Exam II
17
Regulation of Gene Expression (chapters 7,8)
18
Laboratory: DNA Fingerprinting
19
Cell Cycle & Cancer (chapters 18,19,20)
20
Laboratory: Plasmids & Transformation of Bacteria (genotype to phenotype)
21
Laboratory: Amplification of a Gene by PCR
22
Endoplasmic reticulum, lysosomes, microbodies & golgi apparatus (chapter 15)
23
Cytoskeleton (chapter 17) Intermediate filaments, microtubules (including motor proteins, mitosis –
anaphase A/B), assembly of flagellar microtubules. Muscle Contraction
24
Laboratory: Tubulin Immunochemistry
25
Exam III
26
Mitochondria and energy flow (chapter 14)
27,28, 29
Energy Flow & Metabolism (chapter 14) Chloroplasts and photosynthesis (chapter 13,14)
30
Laboratory: Temperature effects on cellular respiration
Comprehensive Final Exam given in accordance with MSU final exam schedule for 3:00 TThF classes.
NAME: DAVID J. SAXON
LA 301C 606-783-2295
d.saxon@moreheadstate.edu
FACULTY SCHEDULE Fall 2012
Time
Mon
Tues
Wed
Thurs
Fri 1
Fri 2
office
office
office
office
office
office
Biol 234-1
LA 130
Class Preparation
&/or Research
8:00
9:10
Biol 234-1
LA 130
Biol 234-1
LA 130
10:20
11:30
Biol
429/629
LA 302
Biol
429L/629L
LA 321
12:40
Biol
429/629
LA 302
Biol
429L/629L
LA 321
1:50
Biol 380L-1
LA 341
3:00
Biol 380L-1
LA 341
Biol 380
LA 311
4:10
Tutor
Session
BIOL 234
LA 130
Biol 380
LA 311
Class
preparation
&/or Research
Biol 380L-2
LA 341
Biol 380L-2
LA 341
office
Office hours may be superseded by meetings, etc.
In addition to the indicated office hours, I am usually in/ near my office (MTWThF – 8:00am to late
afternoon/early evening) except for meetings or classes and am usually available at any of these times.
If I am not in the office, check the lab (LA 341).