Monday
May 6, 2013
LIFE-CHANGING RESEARCH
MAY 5 – 9 | SEATTLE
110
204 GL Section
Business Meeting
207 RE Section
Business Meeting
203 Fibrosis in Glaucoma: Mechanisms
and Therapy — Minisymposium [GL]
#1229-1235
206 CNV: Clinical and Translational
Research [RE] #1242-1247
6B
213 LE Section
Business Meeting
212 Cataract I [LE] #1260-1266
609
216 Peptides and Polypeptides in Ocular 217 PH Section
Health and Dysfunction — Minisymposium Business Meeting
[PH, CO, RC, LE, GL] #1274-1278
618-620
248 Synaptic Mechanisms, Ion Channels
and Gap Junctions [VN] #1754-1760
223 VN Section
Business Meeting
225 EY Section
Business Meeting
219 VI Section
Business Meeting
222 Retinal Circuits and Visual Responses
[VN] #1293-1299
224 Strabismus/Eye Movements [EY]
#1300-1306
218 Aberrations, Image Quality and Visual
Performance [VI] #1279-1285
TCC 304
TCC 305
TCC LL 4/5
246 Cone Photoreceptors in Aging and
Disease [VI] #1740-1746
249 Nanotechnology and Regenerative
Medicine [NT] #1761-1767
247 Surgery: Non-Refractive and
Keratoprothesis [CO] #1747-1753
220 Immunology, Allergy, Neovascularization 221 CO Section
[CO] #1286-1292
Business Meeting
TCC 303
TCC 301/302
271 Tips and Techniques for Using
Proteomics and Metabolomics in Your
Clinical and Translational Research — SIG
[CO, EY, RE, RC, GL]
226 CL Section
Business Meeting
615-617
261 Low Vision Group: Opportunities and
Challenges for Clinical Trials of Treatment
or Rehabilitation Strategies for Vision
Enhancement [LV]
272 Managing Patients with DME,
Neovascular AMD, and RVO: How to Utilize
Data from Clinical Trials — SIG [RE, BI, PH]
265 China-ARVO Networking Forum
264 Members-in-Training Career Forum
263 NEI Grants Workshop: All about Funding
Opportunity Announcements (FOAs)
270 New Insights on the Exploration of
Glaucoma Pathogenesis Using Imaging
Devices — SIG [GL]
269 Using Stem Cells to Model Retinal
Degenerative Disease — SIG [RC, BI,
RE, PH]
262 From Stolen Ideas to False Data:
Shining a Light on Scientific Misconduct
268 Adaptive Optics Retinal Imaging:
Emerging Applications and Expected
Benefits — SIG [RE, RC, VN, VI]
267 Translating Ocular Biomechanics into
Clinical Practice — SIG [GL, CL, PH, LE, CO]
266 Endocannabinoid Signaling in the
Retina – From Biochemistry to Disease to
Therapy — SIG [RC, BI]
281 Low Vision: Central Vision Loss [VI]
#2182-2188
284 Neuroprotection in the Visual
Pathway: Common Mechanisms in Retina,
Optic Nerve and Brain — Minisymposium
[EY, GL, VN, RC] #2203-2207
283 Endothelium [CO] #2196-2202
282 Dry Eye and Lacrimal Gland II [CO]
#2189-2195
280 AMD and Drugs [PH] #2175-2181
279 Retinal Health and Diabetic
Retinopathy: Evidence for Mechanisms,
Treatment, and Risk [CL] #2168-2174
278 Regulation of Eye Development
via Common Transcription Factors and
Signaling Pathways — Minisymposium
[LE, RC] #2163-2167
277 Corneal Infection and Inflammation [IM]
#2156-2162
276 Imaging II, GL [GL] #2149-2155
275 Vitreoretinal Surgery I [RE] #2142-2148
274 Surgery and Laser [GL] #2135-2141
273 Application of Pharmacologic /
Chemical Biologic Approaches to Eye
Disease — Minisymposium [BI] #2131-2134
299B
Weisenfeld
Award Lecture
Student/Trainee Social
4th Floor Lobby
7:30–9pm
Networking Happy
Hour,
Exhibit Halls,
4:30–6pm
WEAVR Silent Auction,
ARVO Central,
9:30am–4pm
NAEVR Central,
Skybridge, 9am–5pm
Exhibit Halls,
11am–6pm
299A Proctor
Award Lecture
1–2:30pm
5:30–
6:45–
Workshop/SIG
2:45–4:30pm
6:30pm
7:30pm
215 RC Section
Business Meeting
245 Genetic Epidemiology: GWAS and
SNPs Around the World [CL] #1733-1739
211 AP Section
Business Meeting
210 Retinoblastoma: Pre-Clinical Models
and Targeted Therapies [AP] #1253-1259
608
214 Neuroprotection in the Retina and RPE
[RC] #1267-1273
244 Microbial Pathogenesis [IM] #1726-1732
209 IM Section
Business Meeting
208 The Untapped Immunomodulating
Potential of Neuropeptides —
Minisymposium [IM, CO] #1248-1252
606/607
611-614
243 DR: Factors and Function [RE]
#1719-1725
205 DME: Clinical Research [RE]
#1236-1241
242 AMD: Translational Research [RE]
#1713-1718
241 Imaging I [GL] #1706-1712
240 Visual Cycle, Retinoids and Carotenoids
[BI] #1699-1705
6E
6C
202 BI Section
Business Meeting
201 Photoreceptor Cilium and Ciliopathies
[BI] #1223-1228
6A
Room
8:30–10:15am
10:15–10:55am
11am–12:45pm
Monday, May 6
111
Ocular Nanotherapy, Nanoparticles, and Gene Therapy [NT]
Optic Nerve: Mechanisms of Damage and Neuroprotection
in Animal and in Vitro Models [EY]
Glaucoma and Optic Neuropathies Imaging [MOI]
Advancement in Imaging Technologies [MOI, VN]
Binocular Vision and Age Effects on Vision [VI]
Retina and Diabetic Retinopathy [CL]
Ocular Disease Expression, Proteomics, Biomarkers, and
Polymorphisms [BI]
Glaucoma Biochemistry and Mechanisms [BI]
Corneal Cross-linking and Biomechanics [CO]
Corneal Endothelium [CO, VN]
229
230
231
232
233
234
235
236
237
238
(D0281-D0333)
(D0246-D0280)
(D0023-D0037)
(D0001-D0022)
(C0020-C0063)
(B0303-B0315)
(B0191-B0243)
(B0158-B0190)
(B0029-B0048)
(B0001-B0028)
(A0055-A0076)
(A0001-A0054)
Cataract Surgery II [LE, CL]
Lasers; Structure and Function I [GL]
Myopia I [AP]
Strabismus/Eye Movements: Central and
Peripheral Factors [EY]
Retina/RPE: New Drugs, Mechanisms of Action,
and Toxicity [PH, BI]
Aqueous Humor Dynamics and IOP [PH]
Retina/RPE: Molecular and Cell Biology [BI]
Immune Responses and Immunopathology [IM]
Corneal Immunology, Allergy, Neovascularization [CO, BI]
Conjunctiva Cell Biology [CO]
252
253
254
255
256
257
258
259
260
#2107-2130
#2053-2106
#2024-2052
#2007-2023
#1969-2006
#1937-1968
#1919-1936
#1904-1918
#1850-1903
#1814-1849
Oxidative/ER Stress and Autophagy in RPE and Retina [RC] #1768-1813
(D0334-D0357)
(D0192-D0245)
(D0163-D0191)
(D0038-D0054)
(C0183-C0220)
(C0151-C0182)
(B0316-B0333)
(B0271-B0285)
(B0104-B0157)
(A0160-A0195)
(A0114-A0159)
ProgramBoard
Number
Number
251
Session
Title
#1646-1698
#1611-1645
#1596-1610
#1574-1595
#1530-1573
#1517-1529
#1464-1516
#1431-1463
#1411-1430
#1383-1410
#1361-1382
#1307-1360
ProgramBoard
Number
Number
250
Session
Number
AMD: Inherited Retinal Degenerations and
Mechanisms of Disease [RC]
228
11am–12:45pm
Genetics of Inherited Eye Disease [GEN]
Session
Title
8:30–10:15am
227
Session
Number
Monday, May 6 n Posters
#2558-2608
#2513-2557
#2502-2512
(D0358-D0408)
(D0118-D0162)
(D0107-D0117)
(D0098-D0106)
(D0084-D0097)
(D0055-D0083)
(C0119-C0150)
(C0064-C0118)
(C0001-C0019)
(B0286-B0302)
(B0244-B0270)
(B0049-B0103)
(A0077-A0113)
Poster board numbers indicate location:
Poster Area A and B = South Exhibit Hall; Poster Area C and D = North Exhibit Hall
Corneal Epithelium and Imaging II [CO, AP]
Autoimmune Ocular Disease/Allergy [IM]
Amacrine and Glial Cells [VN]
#2493-2501
#2479-2492
#2450-2478
#2418-2449
#2363-2417
#2344-2362
#2327-2343
#2300-2326
#2245-2299
#2208-2244
ProgramBoard
Number
Number
4:30–5:30pm: All Posters — authors will be present at poster boards
4:30–6pm: Networking Happy Hour in Exhibit/Poster Halls
297
296
295
Retinal Development [VN]
Biology and Function of Rod and Cone Photoreceptors [VN]
293
294
Phototransduction, Retinal Development,
Molecular Biology and Biochemistry [BI]
DR: Clinical Research II [RE]
DME [RE]
Neuro-Ophthalmology: Inflammation, Ischemia, and
Trauma [EY]
Refractive Errors, Myopia I [VI]
292
291
290
289
288
Imaging Technologies and Applications [MOI]
Structure and Function II [GL]
286
287
Stem and iPS Cells [RC]
Session
Title
285
Session
Number
2:45–4:30pm
NOTES
NOTES
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
112
266
Monday – Papers/Section Business Meetings – 1223 – 1238
6A
6A
Monday, May 06, 2013 8:30 AM-10:15 AM
Monday, May 06, 2013 10:15 AM-10:55 AM
Biochemistry/Molecular Biology
Biochemistry/Molecular Biology
201 Photoreceptor Cilium
and Ciliopathies
202 BI Section Business Meeting
Moderators: Maxim Sokolov and Alecia K. Gross
1224 — 8:45 NUDC is a novel component of
the rab11a-rhodopsin interaction in the inner
segment. Alecia K. Gross1, 2, N. J. Reish2. 1Vision
Sciences, University of Alabama at Birmingham,
Birmingham, AL; 2Vision Sciences, Univ of
Alabama at Birmingham, Birmingham, AL
1225 — 9:00 Addressing the Role of PhLP in
the Folding and Assembly of G-protein βγ dimer.
Maxim Sokolov, S. Sinha, M. Belcastro, X. Gao.
Ophthalmology, West Virginia Univ Eye Institute,
Morgantown, WV
1226 — 9:15 Light-Dependent Phosphorylation
of BBS5 in Photoreceptors and Its Interaction
with Arrestin1. Tyler S. Smith, D. R. Dugger, S.
N. Bolch, J. McDowell, W. Smith. Ophthalmology,
University of Florida, Gainesville, FL
1227 — 9:30 The Essential Role of CCT in
Outer Segment Morphogenesis. Satyabrata
Sinha1, M. Belcastro1, S. Seo2, M. Sokolov1.
1
Ophthalmology, West Virginia University,
Morgantown, WV; 2Ophthalmology and Visual
Sciences, University of Iowa College of Medicine,
Iowa, IA
1228 — 9:45 The farnesylated small GTPase
RAB28 is mutated in autosomal recessive
cone-rod dystrophy. Susanne Roosing1, 2, K.
Rohrschneider3, A. Beryozkin4, N. Weisschuh5, S.
Kohl5, B. Wissinger5, E. Banin4, F. P. Cremers1, 2,
A. I. Den Hollander1, 6. 1Human Genetics,
Radboud University Nijmegen Medical Centre,
Nijmegen, Netherlands; 2Nijmegen Centre for
Molecular Life sciences, Nijmegen, Netherlands;
3
Department of Ophthalmology, University of
Heidelberg, Heidelberg, Germany; 4Department
of Ophthalmology, Hadassah-Hebrew University
Medical Center, Jerusalem, Israel; 5Molecular
Genetics Laboratory, Institute for Ophthalmic
Research, Centre for Ophthalmology, Tuebingen,
Germany; 6Department of Ophthalmology, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands
6B
Monday, May 06, 2013 8:30 AM-10:15 AM
Glaucoma
203 Fibrosis in Glaucoma: Mechanisms
and Therapy - Minisymposium
Normal wound healing is an essential biological
process needed to repair injuries, infection and
trauma. Pathological wound healing leads to fibrosis
and harmful scar tissue formation. The process of
glaucoma is associated with excessive deposition
of extracellular matrix in the trabecular meshwork
and optic nerve regions with resultant fibrosis.
In addition, post trabeculectomy conjunctival
scarring results in surgical failure. Understanding
the mechanisms involved (especially the key role
of contractile myofibroblasts) will help to identify
targets for appropriate therapeutic interventions.
This mini-symposium will present an update on
our current knowledge of fibrosis mechanisms in
conjunctival scarring and matrix alterations in the
trabecular meshwork and optic nerve in glaucoma.
Moderators: Colm J. O’Brien and Abbot F. Clark
1229 — 8:30 Mechanisms in Fibrosis: Cast
a Cold Eye on the Myofibroblast. Boris Hinz.
University of Toronto, Toronto, ON, Canada
1230 — 8:50 Conjunctival Fibrosis Following
Glaucoma Surgery. Gunther R. Schlunck. Div
Experimental Ophthalmology, Univ Eye Hospital
Freiburg, Freiburg, Germany
1231 — 9:04 Trabecular Meshwork
Extracellular Matrix Changes in Glaucoma.
Abbot F. Clark. Cell Biology & Anatomy,
University of North Texas HSC, Fort Worth, TX
*CR
1232 — 9:18 The Role of the Trabecular
Meshwork and Growth Factors in Glaucoma.
Ernst R. Tamm. Inst of Anatomy, University of
Regensburg, Regensburg, Germany
1233 — 9:32 Connective Tissue Changes in the
Optic Nerve Head and Peri-Papillary Sclera in
Glaucoma. Harry Quigley. Ophthalmology, Johns
Hopkins Wilmer Eye Inst, Baltimore, MD *CR
1235 — 10:00 Role of Optic Nerve Astrocytes.
Rudolf Fuchshofer. Institute of Human Anatomy
and Embryology, University of Regensburg,
Regensburg, Germany
6B
Monday, May 06, 2013 10:15 AM-10:55 AM
Glaucoma
204 GL Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. 2013 Trustee Election Results
4. Annual Meeting Program Committee Chair’s
Report
5. Annual Meeting Program Committee Election
Results
6. Other Business
6E
Monday, May 06, 2013 8:30 AM-10:15 AM
Retina
205 DME: Clinical Research
Moderators: Jayashree Sahni and
Usha Chakravarthy
1236 — 8:30 Intraocular Pressure Trends
Following Intravitreal Injections of Anti-VEGF
Agents for Diabetic Macular Edema. Abdulelah
A. Al-Abdullah1, S. R. Nowilaty2, N. G. Ghazi2.
1
Vitreo-retinal, King Khalid Eye Specialist Hospital,
Riyadh, Saudi Arabia; 2KKESH, Riyadh, Saudi
Arabia
1237 — 8:45 Associations of Serum Lipids
with Macular Morphology in Patients without
Diabetic Macular Edema. Mariko Sasaki1, 2,
M. Kawashima1, R. Kawasaki2, 3, M. Kawai1,
A. Uchida1, T. Koto1, H. Shinoda1, K. Tsubota1,
J. Wang2, 4, Y. Ozawa1. 1Ophthalmology, Keio
University, Tokyo, Japan; 2Ophthalmology,
Melbourne University, Melbourne, VIC, Australia;
3
public health, Yamagata University, yamagata,
Japan; 4Ophthalmology, University of Sydney,
Sydney, NSW, Australia *CR
1238 — 9:00 Evaluating SAVE, a novel grading
protocol for the treatment of diabetic macular
edema. Sonja G. Prager, M. Bolz, G. Deak, A.
Pollreisz, B. Pemp, K. Kriechbaum, C. D. Scholda,
U. Schmidt-Erfurth. Ophthalmology and Optometry,
Medical University of Vienna, Vienna, Austria *CR, f
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
113
Monday Papers/Section
Business Meetings
8:30 am – 10:55 am
1223 — 8:30 Nucleotide Binding Status of
rab11a Affects its Localization in Rods and
its Ability to Associate with Outer Segment
Membranes. Nicholas J. Reish1, A. K. Gross2.
1
Vision Sciences / Neurobiology, University of
Alabama at Birmingham, Birmingham, AL; 2Vision
Sciences, University of Alabama at Birmingham,
Birmingham, AL
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. Annual Meeting Program Committee Chair’s
Report
4. Annual Meeting Program Committee Election
Results
5. Other Business
1234 — 9:46 Role of Lamina Cribrosa Cells in
ONH Fibrosis. Deborah M. Wallace. School Med
& Medical Science, University College Dublin,
Dublin, Ireland
Monday Papers/Section
Business Meetings
8:30 am – 10:55 am
1239 – 1252 – Monday – Papers/Section Business Meetings
1239 — 9:15 Double-Masked Trial
Demonstrates Superiority Of Combined
Ranibizumab Plus Laser Versus Laser In
Patients With Diabetic Macular Edema With
Or Without Proliferative Diabetic Retinopathy.
Chris P. Lohmann1, J. Voegeler2, S. Liakopoulos3,
P. M. Wiedemann4, G. Spital5, G. E. Lang6. 1Dept of
Ophthalmology, Klinikum rechts der Isar, Technical
University, Munich, Germany; 2Clinical Research
Speciality Medicine Ophthalmology, Novartis
Pharma GmbH, Nuernbeg, Germany; 3Cologne
Image Reading Cent, Dept of Ophthalmology,
Colgne, Germany; 4Dept of Ophthalmology,
University of Leipzig, Leipzig, Germany; 5Dept of
Ophthalmology, St Franziskus Hospital, Muenster,
Germany; 6Dept of Ophthalmology, University of
Ulm, Ulm, Germany *CR, f
1240 — 9:30 Combination of Ranibizumab and
Navigated Retinal Photocoagulation in Diabetic
Macular Edema, compared to Ranibizumab
Mono-Therapy: Twelve Month Results.
Sarah Cserhati1, 2, R. Liegl1, 2, M. W. Ulbig1, 2, C.
Haritoglou1, 2, A. Kampik1, 2, A. S. Neubauer1, 2, M.
Kernt1, 2. 1Ophthalmology, Ludwig-MaximiliansUniversity of Munich, Munich, Germany;
2
Ophthalmology, LMU, Munich, Germany *CR
1241 — 9:45 Clinically significant
improvement in visual acuity and predictors of
early vision gains in the RIDE and RISE Phase
III trials of ranibizumab for diabetic macular
edema. Lawrence S. Morse1, L. Yau2, L. Tuomi2, J.
S. Ehrlich2. 1Ophthalmology, Univ of CaliforniaDavis, Sacramento, CA; 2Genentech, Inc., South
San Francisco, CA *CR, f
6C
Monday, May 06, 2013 8:30 AM-10:15 AM
Retina
206 CNV: Clinical and
Translational Research
Moderators: James C. Folk and Stephen J. Kim
1242 — 8:30 Suppression of experimental
choroidal neovascularization by curcumin in
mice. Ping Xie, Q. Liu, S. Yuan, Q. Yang, W. Zhang.
Ophthalmology Department, The First Affiliated
Hospital with NanJing Medical University, NanJing,
China
1243 — 8:45 Comparison of Ocular
Pharmacokinetics of Brimonidine and
Dexamethasone in Normal Animal vs. Animal
Models with Choroidal Neovascularization. Jie
Shen1, C. Durairaj1, T. Lin2, Y. Liu3, J. A. Burke2.
1
Pharmacokinetics and Drug Disposition, Allergan,
Irvine, CA; 2Biological Sciences, Allergan, Irvine,
CA; 3Biostatistics, Allergan, Irvine, CA *CR
1244 — 9:00 Functional study of microRNA-24
in ocular angiogenesis. Qinbo Zhou1, A.
Jayagopal2, S. Wang1, 3. 1Cell and Molecular
Biology, Tulane Univercity, New Orleans, LA;
2
Ophthalmology and Version science, Vanderbilt
University Medical Center, Nashville, TN;
3
Ophthalmology, Tulane Univercity, New Orleans,
LA *CR
1245 — 9:15 Impact of Ranibizumab on
Patient-Reported Visual Functioning in Myopic
Choroidal Neovascularization: 3- and 6-Month
Results. Kyoko Ohno-Matsui1, N. Tan2, T. Y.
Wong3, T. Ishibashi4, J. Petrillo5, N. M. Bressler6,
C. Leteneux7. 1Department of Ophthalmology
and Visual Science, Tokyo Medical and Dental
University Hospital, Tokyo, Japan; 2Department
of Ophthalmology, Tan Tock Seng Hospital,
National Healthcare Group Eye Institute, Singapore,
Singapore; 3Department of Ophthalmology,
National University of Singapore, Singapore
Eye Research Institute, Singapore National Eye
Centre, Singapore, Singapore; 4Department of
Ophthalmology, Kyushu University Hospital,
Fukuoka, Japan; 5Novartis Pharmaceuticals
Corporation, East Hanover, NJ; 6Retina Division,
Wilmer Eye Institute, Johns Hopkins University
School of Medicine, Baltimore, MD; 7Novartis AG,
Basel, Switzerland *CR, f
1246 — 9:30 Activated Histoplasmosis Scars.
James C. Folk, M. A. Cunningham, M. D. Abramoff,
E. H. Sohn. Ophthalmology & Visual Sciences,
Univ of Iowa, Iowa City, IA *CR
1247 — 9:45 Twelve-month efficacy and
safety of ranibizumab 0.5 mg(RBZ) versus
verteporfin photodynamic therapy(vPDT) in
the treatment of visual impairment(VI) due to
choroidal neovascularization(CNV) secondary
to pathologic myopia(PM). Francesco Bandello.
Ophthalmology, Univ Vita Salute-Scient Inst San
Raffaele, Milan, Italy *CR, f
6C
Monday, May 06, 2013 10:15 AM-10:55 AM
Retina
207 RE Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. Annual Meeting Program Committee Chair’s
Report
4. Annual Meeting Program Committee Election
Results
5. Other Business
606/607
Monday, May 06, 2013 8:30 AM-10:15 AM
Immunology/Microbiology / Cornea
208 The Untapped Immunomodulating
Potential of Neuropeptides Minisymposium
Neuropeptides are important modulators of
immunity and infection, holding a central role in
regulating immunity, inflammation, and health of
ocular tissues. Because of their ease of application
and therapeutic potential due to low molecular
weight, and potency they influence the course of
inflammation, autoimmune disease, graft rejection,
and infection. Understanding the mechanisms
of both pro and anti-inflammatory neuropeptide
regulation of inflammation has the potential
to facilitate use of these molecules for ocular
inflammatory and infectious disease control.
Moderators: Andrew W. Taylor and
Linda D. Hazlett
1248 — 8:30 VIP and PACAP effects on
macrophages and T cell cytokine production.
Doina Ganea. Microbiology & Immunology,
Temple University, Philadelphia, PA
1249 — 8:51 Modulation of Ocular
Immunobiology by the Neuropeptide alphaMelanocyte Stimulating Hormone. Andrew W.
Taylor. Ophthalmology, Boston Univ School of
Medicine, Boston, MA
1250 — 9:12 CGRP Nerves are a Major
Target for Neuroptotection D1 in Cornea Nerve
Regeneration. Haydee E. Bazan. Ophthal &
Neuroscience, LSU Health Sciences Center, New
Orleans, LA
1251 — 9:33 VIP and SP in Corneal Infection.
Linda D. Hazlett. Anatomy & Cell Biology, Wayne
State Univ Sch of Med, Detroit, MI
1252 — 9:54 Substance P mediated regulation
of herpes simplex keratitis. Susmit Suvas.
Biological Sciences, Oakland University, Rochester,
MI
606/607
Monday, May 06, 2013 10:15 AM-10:55 AM
Immunology/Microbiology
209 IM Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. 2013 Trustee Nomination Results
4. Annual Meeting Program Committee Chair’s
Report
5. Annual Meeting Program Committee Election
Results
6. Other Business
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
114
Monday – Papers/Section Business Meetings – 1253 – 1266
608
Monday, May 06, 2013 8:30 AM-10:15 AM
Anatomy/Pathology
210 Retinoblastoma: Pre-Clinical
Models and Targeted Therapies
Moderators: Patricia Chevez-Barrios and
Rachel Brennan
1254 — 8:45 An Orthotopic Transplantation
Model of Retinoblastoma in Zebrafish: A Novel
Gateway for Screening of Anticancer Drugs.
Dong Hyun Jo1, D. Son2, Y. Na2, M. Jang3, J.
Choi3, J. Kim1, Y. S. Yu1, 4, S. Seok2, J. Kim1, 4. 1Fight
against Angiogenesis-Related Blindness (FARB)
Laboratory, Clinical Research Institute, Seoul
National University Hospital, Seoul, Republic
of Korea; 2Department of Microbiology and
Immunology and Institute of Endemic Disease,
College of Medicine, Seoul National University,
Seoul, Republic of Korea; 3Department of Life
Science, College of Natural Sciences, Hanyang
University, Seoul, Republic of Korea; 4Department
of Ophthalmology, College of Medicine, Seoul
National University, Seoul, Republic of Korea
1255 — 9:00 Expression of Pluripotent
Markers L1CAM and SSEA-5, Common
to Human Retinoblastomas, Xenografts,
Teratomas, Embryonic Tumors and Induced
Pluripotent Stem Cells. Gail M. Seigel1, 6, M.
Choi1, 6, R. Chang2, J. S. Meyer3, B. R. Ksander4,
P. E. Kolovou4, N. E. de Waard5, 4, L. L. Cassidy1, 6.
1
Center for Hearing and Deafness, University at
Buffalo, Buffalo, NY; 2Genetics and Genomic
Sciences, Mount Sinai School of Medicine,
New York, NY; 3Biology, Indiana University,
Indianapolis, IN; 4Ophthalmology, Schepens Eye
Research Institute, Boston, MA; 5Ophthalmology,
Leiden University, Leiden, Netherlands; 6SUNY
Eye Institute, Buffalo, NY
1256 — 9:15 Evaluation of response to
Carboplatin in putative Cancer Stem Cells
of Retinoblastoma Y79 cell line. Geeta K.
Vemuganti1, R. M. Nair1, M. Balla2, S. Honavar3,
M. J. Ali3, V. R. Palkonda4. 1School of Medical
Sciences, University of Hyderabad, Hyderabad,
India; 2Ophthalmic Pathology Laboratory,
L.V.Prasad Eye Institute, Hyderabad, India;
3
Ophthalmic and Facial Plastic Surgery, Orbit
and Ocular Oncology, L.V.Prasad Eye Institute,
Hyderabad, India; 4Apollo Cancer Hospital,
Hyderabad, India
1258 — 9:45 Development of sd-rxRNA® for
Retinoblastoma Therapy. Michael Byrne1, H. P.
Singh2, D. Qi2, J. Cardia1, L. Pandarinathan1, K.
Holton1, K. Bulock1, L. Libertine1, D. Cobrinik2, P.
A. Pavco1. 1Pharmacology, RXi Pharmaceuticals,
Westborough, MA; 2Memorial Sloan-Kettering
Cancer Center, New York, NY *CR
1259 — 10:00 KZ-41 prevents melphalaninduced intercellular adhesion molecule-1
(ICAM-1) upregulation and apoptosis in
retinal endothelial cells. Qiuhua Zhang1, J. J.
Toutounchian2, C. R. Yates2, M. W. Wilson1, J. J.
Steinle1, 3. 1Ophthalmology, Univ of Tennessee Hlth
Sci Ctr, Memphis, TN; 2Pharmaceutical Sciences,
University of Tennessee Health Science Center,
Memphis, TN; 3Anatomy and Neurobiology,
University of Tennessee Health Science Center,
Memphis, TN *CR
1262 — 9:00 Cataract Extraction Outcomes
and the Prevalence of Zonular Insufficiency
in Retinitis Pigmentosa. Clement C. Chow, M.
S. Dikopf, W. F. Mieler, E. Y. Tu. Ophthalmology,
University of Illinois at Chicago, Chicago, IL *CR
1263 — 9:15 The role of periaxin genetic
variances in cataract formation of Gja3
knockout mice. Xiaohua Gong, J. Zeng, C. Cheng,
C. Xia. Vision Sci School of Optometry, University
of California, Berkeley, Berkeley, CA
1264 — 9:30 The Topical Nutraceutical
Optixcare EH Protect Rats Against Ocular
Oxidative Stress. Peter F. Kador1, 2, C. Guo1, H.
Kawada1, K. Blessing1, 2. 1Pharmaceutical Sci, Coll
of Pharm, Univ of Nebraska Medical Ctr, Omaha,
NE; 2Therapeutic Vision, Inc., Omaha, NE *CR
1265 — 9:45 A mutation in a RABGAP is
responsible for cataracts in the blind-sterile (bs)
mouse and Warburg micro syndrome patients.
Duska J. Sidjanin1, B. Chang2, R. P. Liegel1.
1
Medical College of Wisconsin, Milwaukee, WI;
2
Jackson Laboratory, Bar Harbor, ME
1266 — 10:00 Changes in the Pattern of DNA
Methylation in Age-Related Cataract. Peng Zhou,
Y. Lu. Department of Ophthalmology, Eye and ENT
Hospital of Fudan University, Shanghai, China
609
608
Monday, May 06, 2013 10:15 AM-10:55 AM
Anatomy/Pathology
211 AP Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. 2013 Trustee Election Results
4. Annual Meeting Program Committee Chair’s
Report
5. Annual Meeting Program Committee Election
Results
6. Other Business
609
Monday, May 06, 2013 10:15 AM-10:55 AM
Lens
213 LE Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. Annual Meeting Program Committee Chair’s
Report
4. Annual Meeting Program Committee Election
Results
5. Presentation of the National Foundation for
Eye Research 2013 Cataract Research Award
to Professor Paul Donaldson of the Department
of Optometry and Vision Science, University of
Auckland, Auckland, New Zealand.
6. Other Business
Monday, May 06, 2013 8:30 AM-10:15 AM
Lens
212 Cataract I
Moderators: Paul J. Donaldson and
Marjorie F. Lou
1260 — 8:30 A recessive congenital cataract
results from an unstable connexin mutant.
Viviana M. Berthoud, P. J. Minogue, E. C. Beyer.
University of Chicago, Chicago, IL
1261 — 8:45 The role of HIF-1α/-2α and VEGF
in lens epithelial cell survival in hypoxia. Patrick
R. Cammarata, S. Neelam, M. M. Brooks. Cell
Biology & Anatomy, University of North Texas
Hlth Sci Ctr, Fort Worth, TX
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
115
Monday Papers/Section
Business Meetings
8:30 am – 10:55 am
1253 — 8:30 In vivo imaging and
characterization of an orthotopic retinoblastoma
xenograft model. Timothy W. Corson1, 2, A. J.
Geary3, A. Wenzel1, A. Riley4, B. P. McCarthy4, B.
Bailey5, K. E. Pollok5, P. R. Territo4, B. C. Samuels1.
1
Ophthalmology, Indiana University School
of Medicine, Indianapolis, IN; 2Biochemistry
and Molecular Biology, Indiana University
School of Medicine, Indianapolis, IN; 3Eastern
University, St Davids, PA; 4Radiology & Imaging
Sciences, Indiana University School of Medicine,
Indianapolis, IN; 5Pediatrics, Indiana University
School of Medicine, Indianapolis, IN *CR
1257 — 9:30 High Risk Retinoblastoma:
Correlation Between Expression of Angiogenic
Factors and Neovascular Glaucoma. Claudia
M. Prospero Ponce1, D. S. Gombos2, 3, A. S.
Ganapathy1, P. Chevez-Barrios1, 3. 1Pathology
and Genomic Medicine, Ocular Pathology, The
Methodist Hospital, Houston, TX; 2Ophthalmology,
University of Texas, MD Anderson Cancer Center,
Houston, TX; 3Retinoblastoma Center of Houston,
Houston, TX
1267 – 1281 – Monday – Papers/Section Business Meetings
611-614
Monday, May 06, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
214 Neuroprotection in the Retina
and RPE
Monday Papers/Section
Business Meetings
8:30 am – 10:55 am
Moderators: Leonard A. Levin and Janis T. Eells
1267 — 8:30 Photobiomodulation
Preserves Mitochondrial Redox State and is
Retinoprotective in a Rodent Model of Retinitis
Pigmentosa. Janis T. Eells1, S. Gopalakrishnan2,
M. Ranji4, S. Maleki4, B. Abroe1, H. Schmitt6, A. M.
Dubis5, P. Summerfelt3, J. Carroll3. 1Biomedical
Sciences, Univ of Wisconsin - Milwaukee,
Milwaukee, WI; 2Physiology, Medical College
of Wisconsin, Milwaukee, WI; 3Ophthalmology,
Medical College of Wisconsin, Milwaukee, WI;
4
Electrical Engineering and Computer Science,
University of Wisconsin-Milwaukee, Milwaukee,
WI; 5Ophthalmology, Duke University, Durham,
NC; 6Ophthalmology, University of Wisconsin,
Madison, WI *CR
1268 — 8:45 Cytochrome P450 2C9 Is a Target
for Photoreceptor Neuroprotection. Qing Chang1,
S. Chen2, B. Joseph1, D. Cao1, M. A. Grassi1.
1
Ophthal & Visual Sciences, Univ of Illinois Eye &
Ear Infirmary, Chicago, IL; 2Institute for Genomics
& Systems Biology, University of Chicago,
Chicago, IL
1269 — 9:00 Aerobic Exercise Preserves
Retinal Function and Structure in Light Induced
Retinal Degeneration Model. Eric C. Lawson2, 1,
M. K. Han1, 2, J. T. Sellers2, M. A. Chrenek2, S. S.
Jafer2, J. H. Boatright2, M. T. Pardue1, 2. 1Rehab
R&D, Atlanta VA Medical Center, Decatur, GA;
2
Ophthalmology, Emory University School of
Medicine, Atlanta, GA
1270 — 9:15 CNTF-mediated Neuroprotection
in a Mouse Model of Retinitis Pigmentosa
Promotes Outer Segment Elongation and
Requires Cytokine Receptor gp130 Initially in
Müller Glial Cells. Kun Do Rhee1, D. Bok1, 3, S.
Nusinowitz1, K. Chao1, X. Yang1, 2. 1Jules Stein Eye
Institute, University of California, Los Angeles,
CA; 2Molecular Biology Institute, University
of California, Los Angeles, CA; 3Department
of Neurobiology, University of California, Los
Angeles, CA
1271 — 9:30 The hormone prolactin: a novel
endogenous trophic factor able to limit retinal
degeneration. Stephanie Thebault1, E. Arnold1,
A. Quintanar-Stéphano2, G. Rojas-Piloni1, M.
Condés-Lara1, N. Binart3, G. Martinez de la
Escalera1, C. Clapp1. 1Instituto de Neurobiología
UNAM, Querétaro, Mexico; 2Centro de Ciencias
Básicas, Universidad Autónoma de Aguascalientes,
Aguascalientes, Mexico; 3INSERM, Unit 845,
University Paris-Descartes, Faculty of Medicine,
Paris, France
1272 — 9:45 Both caspase-dependent and
capase-independent cell death pathways are
involved in neuronal death in rat retinas exposed
to AGEs. Guzel Bikbova, T. Oshitari, S. Yamamoto.
Ophthalmology & Visual Science, Chiba Univ Grad
School of Medicine, Chuo-ku, Chiba, Japan
1273 — 10:00 Ca2+ signaling in retinal ganglion
cells and their axons. Allison Sargoy1, 3, L. Pérez
de Sevilla Müller1, 2, S. A. Barnes1, 5, N. Brecha1, 4.
1
Neurobiology, UCLA, Los Angeles, CA; 2School
of Medicine, UCLA, Los Angeles, CA; 3Jules Stein
Eye Institute, UCLA, Los Angeles, CA; 4Veterans
Administration, Los Angeles, CA; 5Physiology &
Biophysics, Dalhousie University, Halifax, NS,
Canada
1276 — 9:15 Endothelin: Friend or Foe?
Thomas Yorio. North Texas Eye Research Institute
and Pharmacology & Neuroscience, Univ of North
Texas Hlth Sci Ctr, Fort Worth, TX
1277 — 9:35 Opioid and Natriuretic Peptide
Axis: Nature’s Ocular Neuroprotectants. Shahid
Husain. Ophthalmology, Medical Univ of South
Carolina, Charleston, SC
1278 — 9:55 Bradykinin: A Peptide for All
Seasons. Naj Sharif. Pharma Regulatory Affairs,
Alcon Research Ltd, Fort Worth, TX *CR
618-620
Monday, May 06, 2013 10:15 AM-10:55 AM
Physiology/Pharmacology
611-614
Monday, May 06, 2013 10:15 AM-10:55 AM
Retinal Cell Biology
215 RC Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. 2013 Trustee Nomination Results
4. Annual Meeting Program Committee Chair’s
Report
5. Annual Meeting Program Committee Election
Results
6. Other Business
217 PH Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. Annual Meeting Program Committee Chair’s
Report
4. Annual Meeting Program Committee Election
Results
5. Other Business
TCC LL 4/5
Monday, May 06, 2013 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics
618-620
Monday, May 06, 2013 8:30 AM-10:15 AM
218 Aberrations, Image Quality and
Visual Performance
Physiology/Pharmacology / Cornea / Glaucoma /
Lens / Retinal Cell Biology
Moderators: Harilaos S. Ginis and Jens Buehren
216 Peptides and Polypeptides in
Ocular Health and Dysfunction Minisymposium
This minisymposium explores and discusses
the wide variety of endogenous peptides and
polypeptides that are present in animal and human
ocular systems and details their role in various
functions/ dysfunctions connected with vision.
The physiology and pharmacology of the receptors
and their signal transduction pathways activated
by these agents will be delineated. Furthermore,
the involvement of various peptides in diseases/
disorders of the eye and thus the potential new
treatment modalities will also be discussed.
Moderators: Naj Sharif and Claudio Bucolo
— 8:30 Introduction
1274 — 8:35 Peptides in the Eye: An Overview.
Miguel Coca-Prados. Ophthalmology & Visual Sci,
Yale Univ School of Medicine, New Haven, CT
1275 — 8:55 VEGF and PDGF: Roles in
Physiology and Pathology. Patricia A. D’Amore.
Ophthalmology, Schepens Eye Res Inst, Mass Eye
& Ear, Boston, MA *CR
1279 — 8:30 Optical quality metrics predictive
of visual acuity for the design of wavefront
guided corrections in the presence of dynamic
registration uncertainty. Yue Shi, R. A. Applegate,
A. Ravikumar, H. E. Bedell. College of Optometry,
University of Houston, Houston, TX *CR
1280 — 8:45 Influence of aberration-induced
blur on contrast sensitivity: comparison
of different optotype sizes. Jens Buehren1,
H. Jungnickel2, 3, W. Raab1, D. Weigel3, M.
Gebhardt2, R. Kowarschik3, T. Kohnen1. 1Dept
of Ophthalmology, Goethe University Frankfurt,
Frankfurt am Main, Germany; 2SciTec Department,
Ernst Abbe University of Applied Sciences, Jena,
Germany; 3Institute for Apllied Optics, Schiller
University Jena, Jena, Germany
1281 — 9:00 Visual performance under
natural, corrected and Adaptive Optics
induced astigmatism: meridional and
adaptational effects. Maria Vinas1, P. De
Gracia1, C. Dorronsoro1, L. Sawides1, G. Marin2,
M. Hernandez2, S. Marcos1. 1Visual Optics &
Biophotonics Lab, Instituto de Optica, CSIC,
Madrid, Spain; 2R&D, Vision Science Department,
Essilor International, Saint-Maur, France *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
116
Monday – Papers/Section Business Meetings – 1282 – 1298
1282 — 9:15 Perceptual learning after
correcting the eye’s aberration with adaptive
optics. Ramkumar Sabesan1, 2, G. Yoon1, 2. 1Flaum
Eye Institute, University of Rochester, Rochester,
NY; 2The Institute of Optics, University of
Rochester, Rochester, NY *CR
1283 — 9:30 What is the smallest change in
visual acuity that is correlated with a change
in image quality? Ayeswarya Ravikumar, J.
D. Marsack, Y. Shi, R. A. Applegate. College of
Optometry, University of Houston, Houston, TX
*CR
1285 — 10:00 Impact of the Retinal Reflection
on the Wide-Angle Point Spread Function of the
Human Eye. Harilaos S. Ginis1, 2, G. M. Perez3,
A. Pennos1, J. M. Bueno1, P. Artal1. 1Laboratorio
de Optica, Universidad de Murcia, Murcia, Spain;
2
Institute of Vision & Optics, University of Crete,
Heraklion, Greece; 3Voptica SL, Murcia, Spain *CR
TCC LL 4/5
Monday, May 06, 2013 10:15 AM-10:55 AM
Visual Psychophysics / Physiological Optics
219 VI Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. 2013 Trustee Nomination Results
4. Annual Meeting Program Committee Chair’s
Report
5. Annual Meeting Program Committee Election
Results
6. Other Business
222 Retinal Circuits and
Visual Responses
1290 — 9:30 Understanding the Mechanism of
Donor Bone Marrow Derived Dendritic Cells in
Promoting Corneal Allograft Survival in the Rat.
Thomas Ritter, O. Treacy, A. Ryan, M. Morcos, M.
Cregg, M. Nosov, L. O’Flynn. Medicine, Nt’l Univ
of Ireland, Galway, Galway, Ireland
1294 — 8:45 In vivo optical recording of the
light response of primate ganglion cells. Lu Yin2,
B. D. Masella2, 3, D. Dalkara4, J. Zhang2, J. G.
Flannery4, D. V. Schaffer4, D. R. Williams2, 3, W.
H. Merigan1, 2. 1Flaum Eye Institute, University
of Rochester, Rochester, NY; 2Center for Visual
Science, University of Rochester, Rochester,
NY; 3Institute of Optics, University of Rochester,
Rochester, NY; 4Helen Wills Neuroscience Institute,
University of California, Berkeley, Berkeley, CA
*CR
1291 — 9:45 Influences on effector functions
of monocyte-derived macrophages in corneal
allograft rejection. Thabo Lapp1, 3, N. Simpson1, S.
Zaher2, 1, B. Chain1, T. Reinhard3, M. Noursadeghi1,
F. Larkin2. 1Division of Infection and Immunity,
University College London, London, United
Kingdom; 2NIHR Biomedical Research Centre,
Moorfields Eye Hospital, London, United Kingdom;
3
University Eye Hospital, University Medical
Centre Freiburg, Freiburg, Germany
1292 — 10:00 MMP12 Regulation of Corneal
Inflammation. Matilda F. Chan1, J. Lin1, N.
Ramakrishnan1, Z. Werb2. 1Ophthalmology/Proctor
Foundation, Univ of California-San Francisco, San
Francisco, CA; 2Anatomy, University of California,
San Francisco, San Francisco, CA
Monday, May 06, 2013 10:15 AM-10:55 AM
Monday, May 06, 2013 8:30 AM-10:15 AM
Cornea
Cornea
221 CO Section Business Meeting
1286 — 8:30 Lens-derived Sema3A inhibits
angioblast migration and vascularization of the
developing cornea. Peter Y. Lwigale, C. McKenna.
Biochemistry and Cell Biology-MS140, Rice
University, Houston, TX
Visual Neuroscience
Moderators: Jonathan B. Demb and
William R. Taylor
TCC 303
Moderators: Frank Larkin and Thomas Ritter
Monday, May 06, 2013 8:30 AM-10:15 AM
1289 — 9:15 The CCR7-CCL19/CCL21
Axis Mediates Enhanced Antigen-Presenting
Cell Trafficking In High-Risk Corneal
Transplantation. Jing Hua, W. Stevenson, T. H.
Dohlman, N. Calcagno, N. Pirmadjid, Z. Sadrai,
S. K. Chauhan, D. R. Saban, R. Dana. Schepens
Eye Research Institute, Massachusetts Eye and Ear
Infirmary, Harvard University, Boston, MA *CR
TCC 303
220 Immunology, Allergy,
Neovascularization
TCC 304
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. Annual Meeting Program Committee Chair’s
Report
4. Annual Meeting Program Committee Election
Results
5. Other Business
1287 — 8:45 Cornea Intravital Multiphoton
Visualization of the Resident Mononuclear
Phagocyte Network in Allergy. Tomas Blanco1, M.
Kan2, M. Gunn2, D. R. Saban1, 2. 1Ophthalmology,
Duke University School of Medicine, Durham,
NC; 2Department of Immunology, Duke University
School of Medicine, Durham, NC *CR
1293 — 8:30 Asymmetries between ON and
OFF responses in primate vision first arise in
photoreceptors. Juan Angueyra1, F. Rieke1, 2.
1
Physiology and Biophysics, University of
Washington, Seattle, WA; 2Howard Hughes Medical
Institute, Seattle, WA
1295 — 9:00 Response properties of broad
thorny ganglion cells in the primate retina.
Christian Puller1, M. B. Manookin1, M. Neitz1, F.
Rieke2, 3, J. Neitz1. 1Ophthalmology, University
of Washington, Seattle, WA; 2Physiology and
Biophysics, University of Washington, Seattle, WA;
3
HHMI, Seattle, WA *CR
1296 — 9:15 ON parasol ganglion cells of the
primate retina exhibit directional sensitivity.
Michael B. Manookin1, C. Puller1, F. Rieke2, 3, J.
Neitz1, M. Neitz1. 1Ophthalmology- HSB RR-801,
University of Washington, Seattle, WA; 2Physiology
& Biophysics, University of Washington, Seattle,
WA; 3Howard Hughes Medical Institute, University
of Washington, Seattle, WA *CR
1297 — 9:30 Direction tuning of bipolar
cell glutamate release onto direction-selective
ganglion cells in mouse retina. Silvia Park1, B.
G. Borghuis1, I. Kim1, L. L. Looger3, J. B. Demb1, 2.
1
Ophthalmology & Visual Science, Yale University,
New Haven, CT; 2Cellular & Molecular Physiology,
Yale University, New Haven, CT; 3Janelia Farm
Research Campus, Howard Hughes Medical
Institute, Ashburn, VA *CR
1298 — 9:45 Form and function of the three
ON-type direction-selective retinal ganglion cells
in the Hoxd10 mouse. Maureen E. Estevez1, L. E.
Quattrochi2, 1, O. S. Dhande3, I. Kim1, T. Firman1,
R. Eldanaf3, A. D. Huberman3, D. M. Berson1.
1
Neuroscience, Brown University, Providence,
RI; 2Molecular Pharmacology, Physiology and
Biotechnology, Brown University, Providence, RI;
3
Section of Neurobiology/Neurosciences, University
of California San Diego, La Jolla, CA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
117
Monday Papers/Section
Business Meetings
8:30 am – 10:55 am
1284 — 9:45 Determination of Customized
Aberration Thresholds. Carmen Canovas1, 2, P. A.
Piers1, S. Manzanera2, C. Schwarz2, P. M. Prieto2,
H. A. Weeber1, P. Artal2. 1R&D, AMO Groningen
B.V., Groningen, Netherlands; 2Laboratorio de
Optica, Unversidad de Murcia, Murcia, Spain *CR
1288 — 9:00 Intravital Multiphoton
Microscopy of Corneas and Draining Lymph
Nodes Shows Increased Velocity of Dendritic
Cells after Corneal Transplantation and
Directionality in Corneal Allografts. Takefumi
Yamaguchi1, 2, K. Hu1, 2, D. L. Harris1, 2, P.
Hamrah1, 2. 1Cornea Service and Schepens Eye
Research Institute, Massachusetts Eye and Ear
Infirmary, Boston, MA; 2Harvard Medical School,
Boston, MA
1299 – 1306 – Monday – Papers/Section Business Meetings
1299 — 10:00 Recording the entire visual
representation along the vertical pathway in the
retina. Tom Baden1, 2, P. Berens1, M. Bethge1, 3, T.
Euler1, 2. 1BCCN / CIN, University of Tuebingen,
Tuebingen, Germany; 2Institute for Ophthalmic
Research, University of Tübingen, Tübingen,
Germany; 3Max Planck Institute for Biological
Cybernetics, Tübingen, Germany
TCC 304
Monday Papers/Section
Business Meetings
8:30 am – 10:55 am
Monday, May 06, 2013 10:15 AM-10:55 AM
Visual Neuroscience
223 VN Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. Annual Meeting Program Committee Chair’s
Report
4. Annual Meeting Program Committee Election
Results
5. Other Business
TCC 305
Monday, May 06, 2013 8:30 AM-10:15 AM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
224 Strabismus/Eye Movements
Moderators: Linda K. McLoon and Avery H. Weiss
1300 — 8:30 Health-Related Quality of Life in
Diplopic Patients Treated With Prism. Jonathan
M. Holmes, S. R. Hatt, D. A. Leske, L. Liebermann.
Ophthalmology, Mayo Clinic, Rochester, MN
1301 — 8:45 Displacement of Optical Centers
in Over-the-Counter Readers: A Potential
Cause of Diplopia. Constance E. West1, 2, D. G.
Hunter3, 4. 1Pediatric Ophthalmology, Cincinnati
Children’s Hospital Medical Center, Cincinnati,
OH; 2Department of Ophthalmology, University
of Cincinnati, Cincinnati, OH; 3Department of
Ophthalmology, Boston Children’s Hospital,
Boston, MA; 4Department of Ophthalmology,
Harvard Medical School, Boston, MA *CR
1302 — 9:00 Magnetic Resonance
Imaging (MRI) Demonstrates Differential
Compartmental Contractility of Medial Rectus
Muscle During Vertical Duction. Joseph L.
Demer1, 2, R. A. Clark1. 1Ophthalmology, Jules Stein
Eye Inst, UCLA, Los Angeles, CA; 2Neurology,
Univ. of California Los Angeles, Los Angeles, CA
*CR
1304 — 9:30 Globe Excyclorotation in Crouzon
Syndrome: Relationship to Pattern Strabismus
and Apparent Inferior Oblique Overaction.
Avery H. Weiss1, 2, J. P. Kelly1, 2, J. O. Phillips3, 1.
1
Ophthalmology, Roger Johnson Vision Lab.,
Seattle Children’s Hospital / W-7729, Seattle, WA;
2
Ophthalmology, University of Washington, Seattle,
WA; 3Otolaryngology, University of Washington,
Seattle, WA
1305 — 9:45 Visual fixation as an objective
measure of visual acuity in infants. Amithavikram
R. Hathibelagal1, M. Eizenman2, E. L. Irving1,
S. J. Leat1. 1School of Optometry and Vision
Science, University of Waterloo, Waterloo, ON,
Canada; 2Institute of Biomaterials and Biomedical
Engineering, University of Toronto, Toronto, ON,
Canada
1306 — 10:00 Visual Acuity Deficit in
Idiopathic Infantile Nystagmus Associated with
Current Foveation Characteristcs and History
of Deprivation. Joost Felius1, 2, Z. A. Muhanna1.
1
Retina Foundation of the Southwest, Dallas, TX;
2
Ophthalmology, University of Texas Southwestern
Medical Center, Dallas, TX
TCC 305
Monday, May 06, 2013 10:15 AM-10:55 AM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
225 EY Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. Annual Meeting Program Committee Chair’s
Report
4. Annual Meeting Program Committee Election
Results
5. Other Business
615-617
Monday, May 06, 2013 10:15 AM-10:55 AM
Clinical/Epidemiologic Research
226 CL Section Business Meeting
1. Trustee’s Report of Status of Association
2. ARVO Strategic Plan
3. Annual Meeting Program Committee Chair’s
Report
4. Annual Meeting Program Committee Election
Results
5. Other Business
1303 — 9:15 A Morphometric Analysis of the
Inferior Oblique Muscle in Patients with Inferior
Oblique Overaction. Linda K. McLoon1, J. Felius2,
D. R. Stager3. 1Ophthalmology, University of
Minnesota, Minneapolis, MN; 2Retina Foundation
of the Southwest, Dallas, TX; 3Ophthalmology,
University of Texas Southwestern Medical Center,
Dallas, TX
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
118
Monday – Posters – 1307 – 1324
Exhibit Hall A0001-A0054
Monday, May 06, 2013 8:30 AM-10:15 AM
Genetics
227 Genetics of Inherited Eye Disease
Moderators: Stephen P. Daiger and Eric A. Pierce
1308 — A0002 Genome-Wide Association
Analysis of Canine Retinal Dysplasia and
Vitreous Degeneration. Saija Ahonen1, 2, H.
Lohi1, 2. 1Basic Veterinary Biosciences, University
of Helsinki, Helsinki, Finland; 2Research Programs
Unit, Molecular Neurology, University of Helsinki,
Helsinki, Finland
1309 — A0003 Identification of Novel
Homozygous Deletions in Consanguineous
Pedigrees as a Shortcut to Candidate Gene
Discovery in Retinal Dystrophies. Kristof Van
Schil1, F. Meire2, T. de Ravel3, B. P. Leroy4, H.
Verdin1, F. Coppieters1, E. De Baere1. 1Center for
Medical Genetics, Ghent University Hospital,
Ghent, Belgium; 2Department of Ophthalmology,
Huderf, Brussels, Belgium; 3Center for Human
Genetics, Leuven University Hospitals, Leuven,
Belgium; 4Center for Medical Genetics, Department
of Ophthalmology, Ghent University Hospital,
Ghent, Belgium
1310 — A0004 Novel de novo mutations in
CRX gene associated with Leber congenital
amaurosis in Chinese patients. Ruifang Sui, X.
Zou, F. Dong. Ophthalmology, Peking Union Med
College Hosp, Beijing, China
1311 — A0005 RDH12 mutations associated
with Leber congenital amaurosis and early-onset
severe retinal dystrophy in Chinese patients.
Xuan Zou, F. Dong, R. Sui. Ophthalmology, Peking
Union Medical College Hospital, Beijing, China
1312 — A0006 NMNAT1 p.Arg237Cys
mutation in Japanese patients with Leber
congenital amaurosis. Tomoka Kambe1, T.
Fujimaki2, S. Kawamorita3, E. Arai2, 4, A. Miyazaki2,
K. Fujiki2, F. Iwata5, C. Tamura6, A. Murakami2.
1
Ophthalmology, Saitama Children’s Medical
Center, Saitama, Japan; 2Ophthalmology, Juntendo
University School of Medicine, Tokyo, Japan;
3
Japanese Red Cross Medical Center, Tokyo, Japan;
4
The Tokyo Metropolitan Children’s Medical
Center, Tokyo, Japan; 5Hatanodai Iwata Eye Clinic,
Tokyo, Japan; 6Kiba Park Clinic, Tokyo, Japan *CR
1314 — A0008 Wasf3 is required for
photoreceptor sensory cilia (PSC) formation.
Jingfa Zhang, Q. Zhang, C. Zhang, C. Wu, E.
A. Pierce, Q. Liu. Ocular Genomics Institute,
Department of Ophthalmology, Massachusetts Eye
and Ear Infirmary, Harvard Medical School, Boston,
MA
1315 — A0009 A 353-bp Alu insertion in
MAK is a prevalent cause of recessive retinitis
pigmentosa in North American Jewish patients.
Carlo Rivolta1, G. Venturini1, S. Harper2, H.
Koskiniemi1, E. L. Berson2. 1Department of Medical
Genetics, University of Lausanne, Lausanne,
Switzerland; 2Berman-Gund Laboratory for the
Study of Retinal Degenerations, Harvard Medical
School, Massachusetts Eye and Ear Infirmary,
Boston, MA
1316 — A0010 Clinical and Molecular Findings
in Japanese Cases with KCNV2-retinopathy:
Report of Novel Variants. Yu Kato1, K. Fujinami1,
N. Nakamura1, M. Akahori2, T. Iwata2, K. Tsunoda1.
1
Lab. of Visual Physiology, National Institute
of Sensory Organs, Tokyo, Japan; 2Molecular &
Cellular Biology Division, National Institute of
Sensory Organs, Tokyo, Japan
1317 — A0011 Bioinformatic identification of
altered splicing motifs resulting from the Alu
insertion in exon 9 of the RP gene MAK. S Scott
Whitmore1, S. Zeng1, H. T. Daggett1, A. P. DeLuca2,
B. A. Tucker1, T. A. Braun2, 1, R. F. Mullins1, E. M.
Stone1, T. E. Scheetz1, 2. 1Ophthalmology & Visual
Sciences, University of Iowa, Iowa City, IA;
2
Biomedical Engineering, University of Iowa, Iowa
City, IA *CR
1318 — A0012 Extended Phenotypic
Characteristics of NR2E3-related Enhanced
S-cone Syndrome. Ajoy Vincent1, 2, C.
VandenHoven1, C. A. Westall1, 2, E. Heon1, 2.
1
Ophthalmology and Vision Sciences, Hospital
for Sick Children, Toronto, ON, Canada;
2
Ophthalmology and Vision Sciences, University of
Toronto, Toronto, ON, Canada *CR
1319 — A0013 Phenotypic variability in
paediatric cases of enhanced S-cone syndrome
(ESCS). Gavin Arno1, P. I. Sergouniotis1, A. Dev
Borman1, 2, A. Chandra1, 2, G. E. Holder3, A. G.
Robson3, A. R. Webster1, 2, A. T. Moore1, 2. 1Inherited
Eye Diseases, UCL Institute of Ophthalmology,
London, United Kingdom; 2Moorfields
Eye Hospital, London, United Kingdom;
3
Electrophysiology, Moorfields Eye Hospital,
London, United Kingdom *CR
1320 — A0014 Exon 3 genotypes of OPN1LW/
OPN1MW associated with X-linked congenital
cone dysfunction. Susanne Kohl1, B. Baumann1,
C. P. Hamel2, P. Gustavsson3, T. Rosenberg4, A.
S. Plomp5, B. P. Leroy6, J. Verheij7, B. Wissinger1.
1
Institute for Ophthalmic Reseach, Centre for
Ophthalmology, Tuebingen, Germany; 2Genetic
Sensory Diseases - Hopital Gui de Chauliac,
Centre Hospitalier Universitaire, Montpellier,
France; 3Department of Molecular Medicine and
Surgery, Karolinska Instituet, Stockholm, Sweden;
4
National Eye Clinic for the Visually Impaired,
Kennedy Center, Glostrup, Denmark; 5Department
of Clinical and Molecular Ophthalmogenetics,
NetherlandsInstitute for Neuroscience, Amsterdam,
Netherlands; 6Department of Ophthalmology &
Center for Medical Genetics, Ghent University
Hospital, Ghent, Belgium; 7Universitair Medisch
Centrum Groningen, Groningen University
Hospital, Groningen, Netherlands
1321 — A0015 Fine analysis of the deletions
in red/green opsin genes and the upstream
locus control region (LCR) found in two
Japanese families with blue cone monochromacy
(BCM). Chun-xia Wang1, 3, K. Hosono1, 2, S.
Kachi4, H. Terasaki4, Y. Hotta1, S. Minoshima2.
1
Ophthalmology, Hamamatsu University School
of Medicine, Hamamatsu, Japan; 2Medical
Photobiology, Photon Medical Research Center,
Hamamatsu University School of Medicine,
Hamamatsu, Japan; 3Ophthalmology, The Fourth
Affiliated Hospital of China Medical University,
Shenyang, China; 4Ophthalmology, Nagoya
University School of Medicine, Nagoya, Japan
1322 — A0016 Allelic variation of visual
pigments in capuchin monkeys, Sapajus spp.
Daniela M. Bonci1, 2, M. Neitz3, P. K. Goulart4, J.
G. Soares5, M. Fiorani5, O. F. Galvão4, R. Gattass5,
L. L. Silveira6, 7, D. F. Ventura1, 2. 1Psicologia
Experimental, Universidade de Sao Paulo,
Sao Paulo, Brazil; 2Nucleo de Neurociencias e
Comportamento, Universidade de Sao Paulo, Sao
Paulo, Brazil; 3Departmento of Ophtalmology,
University of Washington, Seattle, WA; 4Nucleo
de Teroria de Pesquisa do Comportamento,
Universidade Federal do Para, Belem, Brazil;
5
Instituto de Biofisica, Universidade Federal do
Rio de Janeiro, Rio de janeiro, Brazil; 6Nucleo de
Medicina Tropical, Universidade Federal do Pará,
Belém, Brazil; 7Instituto de Ciências Biológicas,
Universidade Federal do Pará, Belém, Brazil *CR
1323 — A0017 Retinal gene expression in
mice lacking cones and/or rods identifies genes
potentially involved in human eye function and
disease. Richard J. Holt1, L. Brown1, R. Butler1, S.
M. Downes1, 2, S. N. Peirson1, S. Halford1. 1Nuffield
Department of Clinical Neurosciences, University
of Oxford, Oxford, United Kingdom; 2Oxford Eye
Hospital, National Health Service, Oxford, United
Kingdom *CR
1324 — A0018 Progressive Fundus
Autofluorescence Patterns in Achromatopsia.
Abigail T. Fahim1, N. W. Khan1, S. Zahid1, I.
H. Schachar1, K. E. Branham1, S. Kohl2, B.
Wissinger2, V. M. Elner1, J. R. Heckenlively1, K. T.
Jayasundera1. 1Ophthalmology, Kellogg Eye Ctr,
Univ of Michigan, Ann Arbor, MI; 2Ophthalmology,
University of Tuebingen, Tuebingen, Germany *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
119
Monday Posters
8:30 am – 10:15 am
1307 — A0001 Overview of genetic causes and
identification of novel loci for retinal dystrophies
in Pakistan. Muhammad I. Khan1, 2, M. Azam1, 2,
M. Ajmal1, 3, R. W. Collin1, 4, R. Qamar2, 3, A. I. Den
Hollander1, 5, F. P. Cremers1, 4. 1Human Genetics,
Radboud University Nijmegen Medical Centre,
Nijmegen, Netherlands; 2Biosciences, COMSATS
Institute of Information Technology, Islamabad,
Pakistan; 3Shifa College of Medicine, Shifa Tameere-Millat University, Islamabad, Pakistan; 4Nijmegen
Centre for Molecular Life Sciences, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands; 5Ophthalmology, Radboud University
Nijmegen Medical Centre, Nijmegen, Netherlands
*CR
1313 — A0007 Regulatory mutations
in the 5’UTR of NMNAT1, encoding the
nuclear isoform of nicotinamide nucleotide
adenylyltransferase 1, cause Leber Congenital
Amaurosis. Frauke Coppieters1, A. Baert1, C. Van
Cauwenbergh1, M. Bauwens1, S. De Jaegere1, T.
de Ravel2, F. Meire3, B. P. Leroy4, 1, E. De Baere1.
1
Center for Medical Genetics Ghent, Ghent
University, Ghent, Belgium; 2Center for Human
Genetics, Leuven University Hospitals, Leuven,
Belgium; 3Hôpital Des Enfants Reine Fabiola,
Brussels, Belgium; 4Department of Ophthalmology,
Ghent University Hospital, Ghent, Belgium
Monday Posters
8:30 am – 10:15 am
1325 – 1342 – Monday – Posters
1325 — A0019 Molecular modeling of
functional domain of ABCA4: towards
understanding the genotype-to-phenotype
relationships in Stargardt’s disease. Yuri V.
Sergeev1, K. L. Pogrebniak1, 3, B. Falsini1, 2, W.
M. Zein1, K. Goetz4, J. Huang5, C. E. Peeler5, K.
T. Jayasundera5, B. P. Brooks1, P. A. Sieving1.
1
OGVFB, National Eye Institute, Bethesda, MD;
2
Ophthalmology, Catholic University, Rome, Italy;
3
Princeton University, Princeton, NJ; 4EyeGene,
OGVFB, National Eye Institute, Bethesda, MD;
5
Kellogg Eye Center, University of Michigan, Ann
Arbor, MI *CR
1331 — A0025 Genetic and clinical features
of FEVR and Norrie disease. Eisuke Arai1, 2,
T. Fujimaki1, A. Miyazaki1, K. Fujiki1, F. Iwata3,
T. Inomata1, H. Kawano1, T. Yokoyama4, A.
Okumura5, A. Murakami1. 1Ophthalmology,
Juntendo University School of Medicine, Tokyo,
Japan; 2Ophthalmology, The Tokyo Metropolitan
Children’s Medical Center, Tokyo, Japan;
3
Iwata Ophthalmology Clinic, Tokyo, Japan;
4
Ophthalmology, Juntendo University Nerima
Hospital, Tokyo, Japan; 5Pediatrics and Adolescent
Medicine, Juntendo University School of Medicine,
Tokyo, Japan *CR
1326 — A0020 The frequency of 5 mutations
in the ABCA4 gene in Russian patients with a
clinical diagnosis of Stargardt disease / Fundus
Flavimaculatus. Maria Shurygina1, S. Borzenok1,
O. Khlebnikova2, O. Nekrasova3, O. Kravchuk1.
1
Center for Fundamental Medicine, S.Fyodorov
Eye Microsurgery Complex, Moscow, Russian
Federation; 2Department of Genetic Epidemiology,
Research Centre for Medical Genetics, Russian
Academy of Medical Sciences, Moscow, Russian
Federation; 3M.M. Shemyakin and Yu.A.
Ovchinnikov Institute of bioorganic chemistry of
RAS, Moscow, Russian Federation
1332 — A0026 Presentation and Progression
of the Ocular Manifestations of Methylmalonic
Acidemia in Children. Jacqueline K. Ng, D. J.
Karr, L. Reznick, M. E. Pennesi. Ophthalmology,
Oregon Health & Science Univ, Portland, OR *CR
1327 — A0021 Visual Prognosis and
Association Between Geno - and Phenotype
in Families with ABCA4 Mutations. Ulrika
Kjellstrom1, 2, S. Andreasson1, 2. 1Department of
Ophthalmology, University of Lund, Lund, Sweden;
2
Department of Ophthalmology, Skane University
Hospital, Lund, Sweden
1328 — A0022 Complement Factor Y402H
polymorphism is not associated with Stargardt’s
Disease in Italian Patients. Andrea Sodi1, I.
Passerini2, V. Murro1, L. Boni3, G. Abbruzzese1, A.
Miele1, M. Giuntoli1, G. Mecocci4, F. Torricelli2, U.
Menchini1. 1Department Of Specialistic Surgical
Sciences, Eye Clinic AOU Careggi, University Of
Florence, Firenze, Italy; 2Department of Genetic
Diagnosis, Azienda Ospedaliero Universitaria
Careggi, Firenze, Italy; 3Department of Oncology,
Azienda Ospedaliero Universitaria Careggi,
Firenze, Italy; 4Imperial College, London, United
Kingdom
1329 — A0023 SNRNP200 Mutations Account
for 2% of Autosomal Dominant Retinitis
Pigmentosa. Lori S. Sullivan1, S. J. Bowne1, C.
E. Avery1, D. K. Wheaton2, D. G. Birch2, K. E.
Branham3, J. R. Heckenlively3, S. P. Daiger1.
1
Human Genetics Center SPH, Univ Texas Hlth Sci
Ctr Houston, Houston, TX; 2Retina Foundation of
the Southwest, Dallas, TX; 3Kellogg Eye Center,
University of Michigan, Ann Arbor, MI *CR
1330 — A0024 Impact of CHM Mutations at
the mRNA level. Markus N. Preising, N. Alavi,
B. Lorenz. Department of Ophthalmology, JustusLiebig-University, Giessen, Germany *CR
1333 — A0027 Genotype-Phenotype
correlations in patients with Basal Laminar
Drusen and Systemic Associations. Suman
Pilli1, M. McKibbin2, C. Bailey3, S. Pinto4, J.
Garcia-Fernandez5, H. L. Griffiths6, S. Rodriguez
de Cordoba7, A. J. Lotery8. 1Southampton Eye
Unit, Southampton, United Kingdom; 2St James’s
University Hospital, Leeds, United Kingdom;
3
Bristol Eye Hospital, Bristol, United Kingdom;
4
Centro de Investigaciones Biologicas, Madrid,
Spain; 5Centro de Investigaciones Biologicas,
Madrid, Spain; 6University of Southampton,
Southampton, United Kingdom; 7Centro de
Investigaciones Biologicas, Madrid, Spain;
8
University of Southampton, Southampton, United
Kingdom *CR
1334 — A0028 Novel mutations of the RS1 gene
in a cohort of patients with retinoschisis. Yang Li,
J. Chen, Y. Ren, X. Zhang, Z. Pan. Beijing Inst of
Ophthalmology, Beijing Tongren Hospital, Beijing,
China
1335 — A0029 A knock- in mouse model for
recessive RP-foveoschisis-optic disc drusen and
nanophthamos syndrome due to a mutation
in the Mfrp gene. Bhubanananda Sahu1, V. R.
Chavali1, J. Suk1, R. Poleman1, A. Alapati1, B.
Maranhao1, 2, M. M. Jablonski3, D. G. Bartsch1,
R. Ayyagari1. 1Shiley Eye Center, University
of California, San Diego, San Diego, CA;
2
Bioengineering, University of California, San
Diego, San Diego, CA; 3Hamilton Eye Institute,
University of Tennessee Health Science Center,
Memphis, TN *CR
1336 — A0030 Screening for Usher Syndrome
in an established cochlear implant program:
the merits of a collaborative paradigm. Elise
Heon1, A. Vincent1, J. E. Sutherland1, M. Day1, B. C.
Papsin2, S. L. Cushing2. 1Ophthalmology & Vision
Sciences, The Hospital for Sick Children, Toronto,
ON, Canada; 2Otolaryngology Head and Neck
Surgery, Archie’s Cochlear Implant Laboratory, The
Hospital for Sick Children, Toronto, ON, Canada
1337 — A0031 Tietz syndrome (albinism and
congenital deafness): Description of a familiar
case carrying a novel MITF gene mutation and
associated with nanophthalmos. Luz V. Cortés1,
M. Guzman-Sanchez1, D. C. Guadarrama2, J. C.
Zenteno2, C. Villanueva-Mendoza1. 1Department
of Genetics, Asociación para Evitar la Ceguera en
México I.A.P. Hospital “Dr. Luis Sánchez Bulnes”,
Mexico, Mexico; 2Research Unit and Department
of Genetics, Institute of Ophthalmology “Conde de
Valenciana”, Mexico, Mexico
1338 — A0032 A novel COL2A1 nonsense
mutation causes Stickler syndrome type I.
Mohamed M. Khafagy1, 2, D. F. Schorderet3, 4, H.
Abouzeid5. 1Ophthalmology Department, KasrAlainy Faculty of medicine - Cairo University,
Cairo, Egypt; 2Pediatric Ophthalmology Unit,
Abou-Elreish Pediatric Hospital - Cairo University
Hospitals, Cairo, Egypt; 3IRO - Institut de
Recherche en ophtalmologie, University of
Lausanne, Sion, Switzerland; 4EPFL - Ecole
polytechnique fédérale de Lausanne, Lausanne,
Switzerland; 5Jules-Gonin Eye Hospital, University
of Lausanne, Lausanne, Switzerland
1339 — A0033 Ocular Manifestations and
Genotype-Phenotype Correlations in a group of
12 patients with the Marfan Syndrome. Marta
Latasiewicz1, E. Milla1, C. Fontecilla1, A. Sanchez2.
1
Ophthalmology, Hospital Clinic de Barcelona,
Barcelona, Spain; 2Biochemistry and Molecular
Genetics, Hospital Clinic de Barcelona, Barcelona,
Spain
1340 — A0034 Ocular development and axial
length in the Bestrophinopathies. Julie De
Zaeytijd1, T. Sabbe1, E. De Baere2, B. P. Leroy1, 2.
1
Dept of Ophthalmology, Ghent University
Hospital, Ghent, Belgium; 2Ctr for Medical
Genetics, Ghent University Hospital, Ghent,
Belgium
1341 — A0035 Comparison of human and
murine ocular findings in the Knobloch
syndrome caused by mutations in COL18A1.
Behrad Y. Milani1, S. H. Tsang2, I. H. Maumenee1.
1
Ophthalmology, Univ of Illinois at Chicago,
Chicago, IL; 2Columbia Univ-Harkness Eye Inst,
Columbia Coll phys Surg, newyork, NY
1342 — A0036 Jalili syndrome: retinal
dystrophy and amelogenesis imperfecta:
genotype-phenotype analysis in four new cases.
Christina Gerth-Kahlert1, B. Seebauer2, 3, S. Dold2,
J. Fleischhauer1, H. van Waes4, W. Berger2, 5.
1
Ophthalmology, University of Zurich, Zurich,
Switzerland; 2Institute of Medical Molecular
Genetics, University of Zurich, Zurich, Switzerland;
3
Neuroscience Center Zurich, University of Zurich,
Zurich, Switzerland; 4Center of Dental Medicine,
University of Zurich, Zurich, Switzerland;
5
Zurich Center for Integrative Human Physiology,
University of Zurich, Zurich, Switzerland
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
120
Monday – Posters – 1343 – 1361
1343 — A0037 The RICO mouse - a novel
model of dominant uveal coloboma. Ramakrishna
Alur1, F. I. Onojafe1, A. Dutra5, J. Thomas6, M.
Fruttiger4, W. D. Richardson3, L. Nichols1, P.
F. Hitchcock2, B. P. Brooks1, S. Pieke-Dahl2.
1
Ocular Genetics, NEI / NIH, Bethesda, MD;
2
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 3Cell and Developmental
Biology, Wolfson Institute for Biomedical
Research,University College London, London,
United Kingdom; 4Cell Biology, UCL Institute of
Ophthalmology, London, United Kingdom; 5Genetic
Disease Research Branch, NHGRI/NIH, Bethesda,
MD; 6NIH Intramural Sequencing Center, NHGRI/
NIH, Rockville, MD *CR
1345 — A0039 Inositol 5-Phosphatases in
Primary Cilia Formation in Lowe syndrome.
Yang Sun1, A. Kumar1, M. Conwell1, J. Wang1, R. N.
Weinreb2, N. Luo1. 1Department of Ophthalmology,
Glick Eye Institute Indiana University, Indianapolis,
IN; 2Ophthalmology, University of California, San
Diego, San Diego, CA *CR
1346 — A0040 Evidence of the role of
ADAMTS18 in ocular development. Aman
Chandra1, 2, G. Arno1, P. I. Sergouniotis1, A. Dev
Borman1, A. R. Webster1, 2, A. T. Moore1, 2. 1Cell
Biology, UCL Institute of Ophthalmology, London,
United Kingdom; 2Moorfields Eye Hospital,
London, United Kingdom
1347 — A0041 Allelic Heterogeneity
Contributes to Variability in Ocular Dysgenesis,
Myopathy, and Brain Malformations Caused by
Col4a1 and Col4a2 Mutations. Debbie S. Kuo1,
C. Labelle-Dumais1, M. Mao1, M. Jeanne1, W. B.
Kauffman1, J. Allen1, J. Favor3, D. B. Gould1, 2.
1
Ophthalmology, University of California, San
Francisco, San Francisco, CA; 2Anatomy and
Institute for Human Genetics, University of
California, San Francisco, San Francisco, CA;
3
Institute of Human Genetics, Helmholtz Zentrum
München, Neuherberg, Germany
1348 — A0042 MIR184 c.57C>T mutation
is responsible for congenital cataracts and
corneal abnormalities in a five-generation family
from Galicia, Spain. Yelena Bykhovskaya1, 2, K.
W. Wright3, Y. S. Rabinowitz1, 4, A. C. Canedo1.
1
Cornea Genetic Eye Institute, Beverly Hills, CA;
2
Regenerative Medicine Institute, Cedars-Sinai
Medical Center, Los Angeles, CA; 3Wright Center
for Pediatric Ophthalmology and Strabismus,
Los Angeles, CA; 4The Jules Stein Eye Institute,
University of California Los Angeles, Los Angeles,
CA
1350 — A0044 Crystal deposits in the anterior
lens cortex in Bietti crystalline corneoretinal
dystrophy and first report of chroidal
neovascular membrane in patient affected with
Bietti. Veronika Vaclavik1, 2, F. L. Munier1, 3, D. F.
Schorderet1, 3, V. H. Tran1. 1unité oculogénétique,
Hosp Ophtalmique Jules Gonin Lausanne,
Lausanne, Switzerland; 2Ophtalmology department,
HUG, Geneva, Switzerland; 3Institut de recherche
en Ophtalmology, IRO, Sion, Switzerland
1351 — A0045 Molecular characterization
in Mexican patients with anterior segment
dysgenesis including primary congenital
glaucoma, aniridia, Peters anomaly and
Axenfeld-Rieger anomaly and syndrome. Cristina
Villanueva-Mendoza1, N. Hernández-Martínez2, M.
A. Alcántara-Ortigoza2, O. Honerlage-Ceniceros1,
A. González-Del Angel2, R. B. Barrientos-Ríos2, L.
M. González-Huerta3. 1Genetics, Asociación Para
Evitar La Ceguera En México, México, Mexico;
2
Molecular Biology, Instituto Nacional de Pediatría,
Mexico, Mexico; 3Genetics, Hospital General de
México, SS, Mexico, Mexico
1352 — A0046 Functional characterization
of a homozygous nonsense FOXE3 mutation
that causes Peters anomaly in a consanguineous
family. Arif O. Khan1, S. Y. Khan2, Z. Ma3, S. AlMesfer1, S. Al Turkmani1, S. Riazuddin4, W. Stark2,
J. F. Hejtmancik3, J. D. Gottsch2, S. Riazuddin2.
1
Division of Pediatric Ophthalmology, King Khaled
Eye Specialist Hospital, Riyadh, Saudi Arabia; 2The
Wilmer Eye Institute, Johns Hopkins University
School of Medicine, Baltimore, MD; 3Ophthalmic
Genetics and Visual Function Branch, National
Eye Institute, Bethesda, MD; 4National Centre of
Excellence in Molecular Biology, University of the
Punjab, Lahore, Pakistan *CR
1353 — A0047 Mutant LTBP-2 proteins
lack secretion ability and fibrillin-1 binding
activity. Tomoya O. Akama1, 2, Y. Fujikawa1, T.
Inoue1, T. Nakamura1. 1Pharmacology, Kansai
Medical University, Moriguchi, Japan; 2Tumor
Microenvironment, Sanford-Burnham Med Res
Inst, La Jolla, CA
1354 — A0048 Multiplex Ligation-dependent
Probe Amplification (MLPA) for detection
of large deletions in CYP1B1 in congenital
glaucoma patients from the US. Keri Allen,
M. Janessian, K. Linkroum, W. Abdrabou, J. L.
Wiggs. Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA
1355 — A0049 Clinical features of OPA1related optic neuropathy: a retrospective case
series. Eric Gaier1, 2, P. Skidd3, M. Janessian4, 5,
S. Lessell3, 6, D. Cestari3, 6, J. F. Rizzo3, 6, J. L.
Wiggs4, 5. 1School of Medicine, University of
Connecticut Health Center, Farmington, CT;
2
Neuroscience, University of Connecticut Health
Center, Farmington, CT; 3Neuro-Ophthalmology,
Massachusetts Eye and Ear Infirmary, Boston, MA;
4
Glaucoma, Massachusetts Eye and Ear Infirmary,
Boston, MA; 5Howe Laboratory, Massachusetts
Eye and Ear Infirmary, Boston, MA; 6School of
Medicine, Harvard Medical School, Boston, MA
*CR
1356 — A0050 New candidate genes for
inherited optic atrophy. Cecile Delettre, M.
Hebrard, F. Halloy, A. Roubertie, C. P. Hamel, G.
Lenaers. INSERM, Montpellier, France *CR
1357 — A0051 Pan-American MtDNA
haplogroups in LHON patients. Pablo T.
Romero1, 2, M. A. Slabaugh2, V. Fernández1, N.
Seleme1, P. Pezo1, L. M. Herrera1, M. Moraga1.
1
Universidad de Chile, Santiago de Chile, Chile;
2
University of Washington, Seattle, WA
1358 — A0052 Prenatal Molecular Diagnosis
of Oculocutaneous Albinism (OCA) in a Large
Cohort of Israeli Families. Anat Blumenfeld1,
D. Eli2, I. Bejarano-Achache1, E. Shemesh1,
I. I. Anteby1, C. Yahalom1, 2, A. Rosenmann2.
1
Department of Ophthalmology, Hadassah—
Hebrew University Medical Center, Jerusalem,
Israel; 2Michaelson Institute for Rehabilitation
of Low Vision, Hadassah—Hebrew University
Medical Center, Jerusalem, Israel
1359 — A0053 Molecular diagnostic testing by
eyeGENE®: Analysis of patients with hereditary
maculopathy and/or Cone Rod Dystrophy.
John Suk1, A. Alapati1, K. Goetz2, S. J. Tumminia2,
R. Ayyagari1. 1Shiley Eye Center, University of
California, San Diego, La Jolla, CA; 2National Eye
Inst/NIH, Bethesda, MD *CR
1360 — A0054 Von Hippel Lindau: 3q134X
Mutation Finding. Juan Pablo Davila1, A.
Valladares1, T. Gomez-Villegas2, A. Rojas-Diaz1.
1
Hosp Fdtn Nuestra Senora De La Luz, Mexico,
Mexico; 2Instituto Nacional de Neurologia y
Neurocirugia, Mexico
Exhibit Hall A0055-A0076
Monday, May 06, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
228 AMD: Inherited Retinal
Degenerations and Mechanisms
of Disease
Moderators: Mina M. Chung and
Joe G. Hollyfield
1361 — A0055 AAV-mediated treatment of
retinal degeneration in the Nrf2 knockout mouse.
Katharine J. Liang, K. T. Woodard, R. Samulski.
Gene Therapy Center, Univ of North Carolina
Chapel Hill, Chapel HIll, NC *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
121
Monday Posters
8:30 am – 10:15 am
1344 — A0038 Variable Phenotype & Retinal
Abnormalities in Ectopia Lentis Et Pupillae.
Bart P. Leroy1, C. Boileau2, N. Hanna2. 1Dept
Ophthalmology & Ctr Med Genetics, Ghent
Univ Hosp & Ghent Univ, Ghent, Belgium; 2Lab
de Biochimie, Toxicologie, Hormonologie et
Génétique Moléculaire, Hôpital Ambroise Paré,
Boulogne, France
1349 — A0043 Congenital Cataract Locus in a
Seven Generation Family. Sarah J. Garnai1, J. R.
Huyghe2, D. M. Reed1, K. M. Scott1, M. Boehnke2,
J. E. Richards1, 3, R. Ritch4, 5, H. S. Pawar1.
1
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 2Biostatistics, University
of Michigan, Ann Arbor, MI; 3Epidemiology,
University of Michigan, Ann Arbor, MI; 4Einhorn
Clinical Research Center, New York Eye and
Ear Infirmary, New York, NY; 5Department of
Ophthalmology, New York Medical College,
Valhalla, NY
1362 – 1382 – Monday – Posters
Monday Posters
8:30 am – 10:15 am
1362 — A0056 Retinal Histopathology in Eyes
from Patients with Autosomal Recessive Retinitis
Pigmentosa Caused by EYS Mutations. Gayle
J. Pauer1, V. L. Bonilha1, M. E. Rayborn1, B. A.
Bell1, M. J. Marino1, C. D. Beight1, J. Chiang2, E. I.
Traboulsi1, S. A. Hagstrom1, J. G. Hollyfield1. 1Cole
Eye Institute, Cleveland Clinic, Cleveland, OH;
2
Casey Eye Institute, Portland, OR *CR
1363 — A0057 Retinal Histopathology in Eyes
from a Patient with Stargardt Disease Caused by
Compound Heterozygous ABCA4 Mutations. Joe
G. Hollyfield1, V. L. Bonilha1, M. E. Rayborn1, B. A.
Bell1, M. J. Marino1, G. A. Fishman2. 1Ophthalmic
Research, Cole Eye Institute, Cleveland Clinic,
Cleveland, OH; 2Chicago Lighthouse For People
Who Are Blind or Visually Impaired, Chicago, IL
1364 — A0058 Retinal Histopathology in
Eyes from Patients with Autosomal Dominant
Retinitis Pigmentosa caused by Rhodopsin
Mutations. Mary E. Rayborn, V. L. Bonilha, B.
A. Bell, X. Yang, M. J. Marino, G. J. Pauer, C.
D. Beight, E. I. Traboulsi, S. A. Hagstrom, J. G.
Hollyfield. Ophthalmology, Cole Eye Institute/
CCLCM, Cleveland, OH *CR
1365 — A0059 Mitochondrial retinal
dystrophy: genetic background, clinical
classification, and systemic associations.
Camiel J. Boon1, 2, P. de Laat3, M. Janssen4, J. A.
Smeitink3, J. E. Keunen1. 1Ophthalmology, Radboud
Nijmegen Univ Med Ctr, Nijmegen, Netherlands;
2
Ophthalmology, Oxford Eye Hospital, University
of Oxford, Oxford, United Kingdom; 3Paediatrics,
Radboud Nijmegen Univ Med Ctr, Nijmegen,
Netherlands; 4Internal Medicine, Radboud
Nijmegen Univ Med Ctr, Nijmegen, Netherlands
*CR
1366 — A0060 Retinal Lamination Patterns
in Macular Retinoschisis. Hilary S. Brader, B.
VanderBeek, A. M. Maguire, J. Ruggiero, P. J.
Tapino, A. J. Brucker, T. S. Aleman. Ophthalmology,
Scheie Eye Institute, University of Pennsylvania,
Philadelphia, PA
1367 — A0061 Interocular Difference and
Interocular Correlation in Visual Acuity and
Focal Macular Electroretinogram in Stargardt
Disease Patients with an ABCA4 Genotype.
Dario Marangoni1, M. Piccardi1, A. M. Minnella1,
M. Bertelli2, D. Degiorgio2, M. Zuntini2, S. Bisti3,
B. Falsini1. 1Ophthalmology, Catholic University
of Sacred Heart, Rome, Italy; 2Laboratory for
molecular genetics in rare diseases, MAGI,
Rovereto, Trento, Italy; 3Dipartimento di Scienze
Cliniche ed Applicate Biotecnologiche, University
of L’Aquila, L’Aquila, Italy
1368 — A0062 Late-Onset Retinal Macular
Degeneration: refining the phenotype.
Shyamanga Borooah1, V. T. Papastavrou3,
A. Browning3, B. Dhillon2. 1MRC Centre for
Regenerative Medicine, University of Edinburgh,
Edinburgh, United Kingdom; 2Ophthalmology,
University of Edinburgh, Edinburgh, United
Kingdom; 3Department of Ophthalmology,
Newcastle upon Tyne Hospitals NHS Foundation
Trust, Newcastle upon Tyne, United Kingdom
1369 — A0063 Analysis of Phenotype in Mouse
Models of Stargardt Disease for Identification
of Modifying Genes. Benjamin Bakall1, M. J.
Riker1, P. P. Patankar1, R. M. Johnston1, D. K.
Brack1, J. Riley1, R. F. Mullins1, M. G. Anderson2,
E. M. Stone1. 1Ophthalmology and Visual Sciences,
University of Iowa, Iowa City, IA; 2Molecular
Physiology and Biophysics, University of Iowa,
Iowa City, IA *CR
1370 — A0064 Microperimetric analysis for
investigation of ABCA4-related Stardgardt’s
disease progression. Marcella Attanasio, S.
Rossi, F. Testa, P. Melillo, V. Di Iorio, A. Nesti, F.
Simonelli. Second University of Naples, Napoli,
Italy
1371 — A0065 Rule of multifocal
electroretinogram in follow-up of ABCA4-related
Stardgardt’s disease. Ada Orrico, F. Testa, S.
Rossi, P. Melillo, A. de Benedictis, M. Della Corte,
F. Simonelli. Second University of Naples, Naples,
Italy
1372 — A0066 Adaptive Optics Scanning Laser
Ophthalmoscopy Demonstrates Reduced Foveal
Cone Density in Pattern Dystrophy. Xiaofei
Wang1, H. Song2, M. A. Folwell2, L. R. Latchney1,
M. M. Chung1, 2. 1Flaum Eye Institute, University
of Rochester, Rochester, NY; 2Center for visual
science, University of Rochester, Rochester, NY
*CR
1373 — A0067 PARP1 Knock-Out Mice
Prevents N-methyl-N-nitrosourea-induced
Photoreceptor Degeneration. Xinrong Zhou1, 2, T.
Masuda1, Z. Yang1, G. C. Shaw1, C. A. Berlinicke1,
S. A. Andrabi3, 4, Y. Wang3, V. L. Dawson3, 5, T. M.
Dawson3, 4, D. J. Zack1. 1Dept of Opthalmology,
Johns Hopkins University School of Medicine,
Baltimore, MD; 2Dept of Opthalmology, Harbin
Medical University, the 2nd Affiliated Hospital,
Harbin, China; 3Neuroregeneration Program,
Institute for Cell Engineering, Johns Hopkins
University School of Medicine, Baltimore, MD;
4
Dept of Neurology, Johns Hopkins University
School of Medicine, Baltimore, MD; 5Solomon H.
Snyder Department of Neuroscience, Johns Hopkins
University School of Medicine, Baltimore, MD *CR
1374 — A0068 The Role of Phospholipid
Transfer Protein (PLTP) in Lipoprotein
Metabolism in the Retina. Amirfarbod
Yazdanyar1, 3, X. Jiang1, D. R. Lazzaro2, 3, W. J.
Brunken2, 3. 1Cell Biology, SUNY Downstate
Medical Center, Brooklyn, NY; 2Ophthalmology,
SUNY Downstate Medical Center, Brooklyn, NY;
3
SUNY Eye Institute, Brooklyn, NY
1375 — A0069 The Role of Microglia in Retinal
Degeneration of Mice with Defective NR2E3
Gene. Nan-Kai Wang1, 2, C. Lai1, C. Liu2, L. Yeh1,
T. Nagasaki3, S. H. Tsang3. 1Ophthalmology, Chang
Gung Memorial Hospital, Tao-Yuan, Taiwan;
2
Anatomy and Cell Biology, National Taiwan
University, Taipei, Taiwan; 3ophthalmology, Edward
S. Harkness Eye, New York, NY
1376 — A0070 Heme oxygenase-1 gene
therapy in a mice model of atrophic age-related
macular degeneration. Ming-Hui Sun1, Y. Tsao2,
K. Chen1. 1Ophthalmology, Chang Gung Memorial
Hospital-LinKou, Kwei-Shan, Tao-Yuan, Taiwan;
2
ophthalmology, Chang Gung Memorial Hospital,
Taoyuan, Taiwan
1377 — A0071 CD59a deficiency leads to
increased age-related subretinal macrophage
accumulation and elevated local C3 expression
in the RPE/choroid complex of aged mice.
Philipp Herrmann, J. Cowing, U. F. Luhmann, R.
R. Ali. Department of Genetics, UCL Institute of
Ophthalmology, London, United Kingdom
1378 — A0072 Regulation of the cholesterol
efflux transporters ABCA1/ABCG1 in retina
in hemochromatosis and by the endogenous
iron chelator 2,5-dihydroxybenzoic acid. Sudha
Ananth1, B. R. Baldowski1, P. M. Martin1, 3, S.
B. Smith2, 3, V. Ganapathy1. 1Biochemistry and
Molecular Biology, Georgia Health Sciences
University, Augusta, GA; 2Cellular Biology and
Anatomy, Georgia Health Sciences University,
Augusta, GA; 3Ophthalmology, Georgia Health
Sciences University, Augusta, GA
1379 — A0073 Regulation of the cholesterol
efflux transporter ABCA1 by the niacin
receptor GPR109A: potential relevance to
drusen biogenesis and inflammation in agerelated macular degeneration (AMD). Wanwisa
Promsote1, R. Veeranan-Karmegam1, S. Ananth1,
V. Ganapathy1, P. M. Martin1, 2. 1Biochemistry and
Molecular Biology, Georgia Health Sciences Univ,
Augusta, GA; 2Ophthalmology, Georgia Health
Sciences University, Augusta, GA
1380 — A0074 Comparison of autophagy in
hfRPE and ARPE-19 as two different models
to study the pathogenesis of AMD. Haben F.
Kefella1, S. Pakneshan1, T. A. van Zyl1, R. A.
Adelman1, L. J. Rizzolo2, 1. 1Ophthalmology, Yale
School of Medicine, New Haven, CT; 2Surgery, Yale
University School of Medicine, New haven, CT
1381 — A0075 Age-Associated Changes
of mTOR Signaling in The Retinal Pigment
Epithelium. Bo Yu1, Z. Zhao1, Y. Zuo1, P. Xu1,
P. Sternberg2, Y. Chen1. 1Ophthalmology, The
University of Texas Medical Branch at Galveston,
Galveston, TX; 2the Vanderbilt Eye Institute,
Vanderbilt University, Nashville, TN
1382 — A0076 Vectorial release of matrix
metalloproteinase enzymes from porcine RPE
in explant culture following nanosecond laser
exposure. Ling Zhi Heng1, 2, A. A. Hussain1,
S. Sivaprasad2, R. D. Hamilton2, J. Marshall1.
1
Institute of Ophthalmology, London, United
Kingdom; 2Medical retina, Moorfields Eye Hospital,
London, United Kingdom *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
122
Monday – Posters – 1383 – 1402
Exhibit Hall B0001-B0028
Monday, May 06, 2013 8:30 AM-10:15 AM
Nanotechnology and Regenerative Medicine
229 Ocular Nanotherapy,
Nanoparticles, and Gene Therapy
Moderators: Jose A. Sahel and
Alexander V. Ljubimov
1384 — B0002 Protein-Based Retinal Implant.
Nicole L. Wagner1, J. A. Greco2, R. R. Birge2.
1
Molecular and Cell Biology, University of
Connecticut, Storrs, CT; 2Chemistry, University of
Connecticut, Storrs, CT *CR
1385 — B0003 Kinetics of dexamethasone
cyclodextrin nanoparticle suspension eye
drops in tear fluid. Gauti Johannesson1, 4, M. D.
Moya-Ortega2, G. M. Asgrimsdottir3, T. Loftsson2,
E. Stefánsson1. 1Department of Ophthalmology,
University of Iceland, Reykjavik, Iceland; 2Faculty
of Pharmaceutical Sciences, University of Iceland,
Reykjavik, Iceland; 3Oculis ehf., Reykjavik,
Iceland; 4Department of Clinical Sciences,
Ophthalmology, Umeå University, Umeå, Sweden
*CR
1386 — B0004 Engineering a biocompatible
cell carrier with nanofeatured topography for
retinal pigment epithelium transplantation.
Zengping Liu1, N. Yu2, F. G. Holz1, F. Yang2, B. V.
Stanzel1. 1Ophthalmology, University of Bonn,
Bonn, Germany; 2Department of Biomaterials,
Radboud University Nijmegen Medical Center,
Nijmegen, Netherlands *CR
1387 — B0005 Proliferation of porcine
conjunctival fibroblasts in fibrin-based scaffolds
using alamar blue assay. Ana Fernández1, J.
Ramos1, M. López1, P. Pérez1, E. Santín1, L.
Llorente1, Y. Diebold2, F. Iglesias1. 1Human Tissue
Bank, San Francisco Clinic Foundation, León,
Spain; 2Ocular Surface Group, IOBA-University of
Valladolid, Valladolid, Spain
1388 — B0006 Novel pentablock copolymers as
a nanotechnology platform for controlled ocular
delivery of proteins. Sulabh Patel, G. Mishra, V.
Tamboli, A. K. Mitra. Pharmaceutical Sciences,
University of Missouri Kansas City, Kansas City,
MO
1390 — B0008 Lab-on-a-tube for in situ ocular
bioassays: continuous glucometry in tears.
Andrew W. Browne1, C. Li2. 1Ophthalmology,
University of Southern California Doheny
Eye Institute, Los Angeles, CA; 2Cushing
Neuromonitoring Laboratory, Feinstein Institute for
Medical Research, Manhasset, NY
1391 — B0009 The effect of retinoic acid
to induce one of the perioculer neural crest.
Motokazu Tsujikawa1, E. Kimura1, Y. Oie1, T. Soma1,
S. Hara1, R. Hayashi1, S. Hatou2, S. Yoshida2, S.
Shimmura2, K. Nishida2. 1Ophthalmology, Osaka
University, Suita, Japan; 2Ophthalmology, Keio
University, Tokyo, Japan *CR
1392 — B0010 Tissue Engineered Model of
the Outer Neural Retina and Retinal Pigment
Epithelium. Karl E. Kador1, 2, E. Salero1, 2, K.
R. Russano1, 2, L. W. Lau1, 2, J. L. Goldberg1, 2.
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2Interdisciplinary Stem Cell Institute,
University of Miami Miller School of Medicine,
Miami, FL
1393 — B0011 Regenerative response of optic
nerve axons while using a specifically designed
hydrogel. Arieh S. Solomon1, A. Nitzan1, M. Aviv2,
S. Einav2, E. Gazit3, Z. Nevo4. 1Eye Research
Institute, Tel Aviv University, Ramat Gan, Israel;
2
Biomedical Engineering, Tel Aviv University,
Tel Aviv, Israel; 3Molecular Microbiology &
Biotechnology, Tel Aviv University, Tel Aviv, Israel;
4
Human Molecular Genetics & Biochemistry, Tel
Aviv University, Tel Aviv, Israel
1394 — B0012 Biocompatibility of helicoidal
multi-lamellar features of RGD-functionalized
silk biomaterials for tissue engineering cornea.
Liqiang Wang, H. Guo, Y. Dong, G. Du, Y. Huang,
L. Jia. Ophthalmology, Chinese PLA General
hospital, Beijing, China
1395 — B0013 A Novel Fish Scale Derived
Scaffold for Ocular Reconstruction. Tine
Possemiers1, 2, N. Zakaria1, 2, V. Van Gerwen2, S.
Chen3, H. J. Lai3, 4, C. C. Lin4, M. B. Tassignon1, 2.
1
Ophthalmology, Antwerp University Hospital,
Edegem, Belgium; 2University of Antwerp,
Antwerp, Belgium; 3Research and Development,
Aeon Astron Europe B.V., Leiden, Netherlands;
4
Research and Development, Body Organ
Biomedical Corp., Taipei, Taiwan *CR
1396 — B0014 Ascl1 reprograms Müller
glia into functional retinal neurons. Julia
Pollak1, 2, M. Wilken1, 3, Y. Ueki1, K. E. Cox1, R. J.
Taylor1, T. A. Reh1, 2. 1Department of Biological
Structure, University of Washington, Seattle, WA;
2
Neurobiology and Behavior Program, University of
Washington, Seattle, WA; 3Molecular and Cellular
Biology Program, University of Washington,
Seattle, WA
1397 — B0015 Chitosan-Gelatin Biopolymers
as Carrier Substrata for Limbal Epithelial Stem
Cells. Teresa Nieto-Miguel1, 3, A. de la Mata1, 3, M.
López-Paniagua1, 3, S. Galindo1, 3, M. R. Aguilar2, 3,
L. García-Fernández2, 3, B. Vazquez2, 3, J. San
Román2, 3, R. M. Corrales1, 3, M. Calonge1, 3. 1Ocular
Surface Group-IOBA, University of Valladolid,
Valladolid, Spain; 2Group of Biomaterials, Institute
of Polymer Science and Technology, CSIC, Madrid,
Spain; 3Biomedical Research Networking center in
Bioengineering, Biomaterials and Nanomedicine
(CIBER-BBN), Valladolid and Madrid, Spain *CR
1398 — B0016 Different aligned multiwalled
carbon nanotubes an their effects on cell viability
and growth charactaristics. Claudia Etzkorn1,
S. Johnen1, F. Meissner2, I. Endler2, P. Walter1.
1
Department of Ophthalmology, RWTH Aachen
University, Aachen, Germany; 2Frauenhofer
Institute for Ceramic Technologies and Systems,
Dresden, Germany *CR
1399 — B0017 Keratin-chitosan membranes
as scaffold for tissue engineering of human
cornea. Alvaro Meana1, 3, N. Vázquez1, M. Chacón1,
Y. Menéndez-Menéndez2, A. Ferrero-Gutierrez2, J.
Merayo-Lloves1, 3. 1Superficie Ocular, Fundación
de Investigación Oftalmológica, Oviedo, Spain;
2
Transplantes y Terapia Celular, Hospital Central de
Asturias, Oviedo, Spain; 3Universidad de Oviedo,
Oviedo, Spain *CR
1400 — B0018 Restoration of light sensitivity
to blind mice with red-shifted chemical
photoswitches. Ivan Tochitsky1, A. Polosukhina1, A.
Noblet1, D. Trauner2, R. H. Kramer1. 1Molecular and
Cell Biology, University of California, Berkeley,
Berkeley, CA; 2Department Chemie, LudwigMaximilians-Universität München, München,
Germany *CR
1401 — B0019 In Vivo Functional Comparison
of Polarized and Non-polarized hESC-RPE Cells
Transplantation in RCS Rats. Laura Liu1, 2, B. B.
Thomas3, R. Ribeiro3, A. Gonzalez-Calle3, D. Zhu4, 3,
P. B. Thomas3, K. Lin3, Y. Hu3, D. R. Hinton4, 3, M.
S. Humayun3. 1Cell and Neurobiology, University
of Southern California, Los Angeles, CA;
2
Ophthalmology, Chang Gung Memorial Hospitial,
Taoyuan, Taiwan; 3Ophthalmology, Doheny Eye
Institute, Los Angeles, CA; 4Pathology, University
of Southern California, Los Angeles, CA *CR
1402 — B0020 Tissue Engineering of a Human
Choroid Containing a Vascular Network and
Melanocytes. Stephanie Proulx1, 2, M. Guimond1, O.
Rochette-Drouin1, S. Landreville1, 2. 1LOEX/CUO Recherche, Centre de recherche du CHU, Quebec,
QC, Canada; 2Ophtalmologie, Université Laval,
Quebec, QC, Canada
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
123
Monday Posters
8:30 am – 10:15 am
1383 — B0001 Use of Polymeric Scaffolds
as Extracellular Matrix Substitutes for
Conjunctival Epithelial Repair. Thomas
Storr-Paulsen1, 3, M. Fullana2, A. L. Wang1, D.
Karamichos1, T. P. Utheim1, 4, M. A. Shatos1, J.
Hjortdal3, G. E. Wnek2, D. A. Dartt1. 1Schepens
Eye Research Institute, Massachusetts Eye and Ear,
Harvard Medical School, Boston, MA; 2Department
of Macromolecular Science and Engineering,
Case Western Reserve University, Cleveland, OH;
3
Department of Ophthalmology, Aarhus University
Hospital NBG, Aarhus, Denmark; 4Department of
Medical Biochemistry, Oslo University Hospital,
Oslo, Norway *CR
1389 — B0007 Acuboost™: Enhancing
the maximum acuity of the Argus II Retinal
Prosthesis System. Jose A. Sahel1, 2, S. MohandSaid2, 1, P. E. Stanga4, 3, A. Caspi5, R. J. Greenberg5.
1
UMR-S 968, Institut de la Vision, Paris, France;
2
CHNO des Quinze-Vingts, INSERM-DHOS CIC
503, Paris, France; 3Manchester Academic Health
Science Centre and Centre for Ophthalmology and
Vision Research, Institute of Human Development,
University of Manchester, Manchester, United
Kingdom; 4Manchester Vision Regeneration (MVR)
Lab, Manchester Royal Eye Hospital, Manchester,
United Kingdom; 5Second Sight Medical Products,
Sylmar, CA *CR, f
1403 – 1425 – Monday – Posters
Monday Posters
8:30 am – 10:15 am
1403 — B0021 A polymer-based interface
restores light sensitivity in rat blind retinas.
Maurizio Mete1, G. Pertile1, D. Ghezzi2, M.
Antognazza3, R. Maccarone4, E. Lanzarini3, N.
Martino3, S. Bisti4, G. Lanzani3, F. Benfenati2.
1
Ophthalmology, Ospedale Sacro Cuore, Verona,
Italy; 2Department of Neuroscience and Brain
Technologies, Istituto Italiano di Tecnologia,
Genova, Italy; 3Center for Nanoscience and
Technology, Istituto Italiano di Tecnologia @
POLIMI, Milano, Italy; 4Department of Biomedical
Technology, University of L’Aquila, L’Aquila, Italy
1404 — B0022 Reconstruction of the ocular
surface with adipose-derived stem cells (ASCs).
Almudena Del Hierro1, A. Boto1, I. García
Gomez2, M. García-Arranz3, A. Insausti García1, F.
Armada1. 1Oftalmología, Hospital La Paz, Madrid,
Spain; 2Medicine, University of Illinois, Chicago,
IL; 3Laboratorio de Terapia Celular, Hospital
Universitario La Paz, Madrid, Spain *CR
1405 — B0023 Development of a
Microemulsion Library for Drug Screening.
Drew Wassel2, 1, F. Mondalek2, 1, A. B. Quiambao2, 1,
R. Farjo2, 1. 1Charlesson LLC, Oklahoma City, OK;
2
EyeCRO, Oklahoma City, OK *CR
1406 — B0024 Early data on the effect of
continuous positive airway pressure (CPAP) on
intraocular pressure (IOP) changes measured
by a contact lens sensor (CLS) in patients with
obstructive sleep apnea syndrome (OSAS) with
and without primary open-angle glaucoma
(POAG). Jessica V. Jasien1, R. Goedkoop2, C.
Pillai1, S. Simon-Zoula2, R. Ritch1, 3. 1Einhorn
Clinical Research Center, New York Eye and
Ear Infirmary, New York, NY; 2Sensimed AG,
Lausanne, Switzerland; 3New York Medical
College, Valhalla, NY *CR, f
1407 — B0025 Optimized cell-handling
of human embryonic stem cells in the
differentiation of photoreceptor precursor
cells. Christopher R. Laver, A. Yanai, A. Joe, I.
viringipurampeer, X. Wang, A. Metcalfe, C. Y.
Gregory-Evans, K. Gregory-Evans. Ophthalmology
& Visual Sciences, University of British Columbia,
Vancouver, BC, Canada
1408 — B0026 Mesenchymal stem cell based
ex vivo gene therapy provides enhanced
neuroprotection in X-linked retinoschisis
mouse model. AMA E. Bashar, A. Metcalfe, I.
Viringipurampeer, C. Y. Gregory-Evans, O. L.
Moritz, K. Gregory-Evans. Ophthalmology &
Visual Sciences, University of British Columbia,
Vancouver, BC, Canada
1409 — B0027 Histological correlation of
superior collicus response to light preserved
by transplantation of hESC derived RPE
monolayer in RCS rats. Biju B. Thomas1, P. B.
Thomas1, L. Liu2, 3, Y. Hu1, D. Zhu1, 4, D. O. Clegg5,
D. R. Hinton1, 4, M. S. Humayun1. 1Ophthalmology,
Doheny Eye Institute, Los Angeles, CA; 2Cell and
Neurobiology, University of Southern California,
Los Angeles, CA; 3Ophthalmology, Chang
Gung Memorial Hospital, Taoyuan, Taiwan;
4
Pathology, University of Southern California,
Los Angeles, CA; 5Center for Stem Cell Biology
and Engineering, University of California-Santa
Barbara, Santa Barbara, CA *CR
1410 — B0028 Generation of engineered
human corneal lenticule with epithelium for
selective allograft. Man-Il Huh1, 2, E. Yeo1, J. Lee1,
H. Kim1, 2. 1Ophthalmology, Kyungpook national
university school of medicine, Daegu, Republic of
Korea; 2Joint Institute for Regenerative Medicine,
Kyungpook National University Hospital, Daegu,
Republic of Korea
1417 — B0035 Retinal ganglion cell loss and
inflammatory demyelination in an experimental
autoimmune encephalomyelitis model. Lioba
Horstmann1, H. Schmid1, F. Kurschus2, A. Waisman2,
B. H. Dick1, S. C. Joachim1. 1Experimental Eye
Research Institute, Knappschaftskrankenhaus
Bochum, Bochum, Germany; 2Institute for
Molecular Medicine, University Medical Center
of the Johannes Gutenberg University, Mainz,
Germany *CR
Exhibit Hall B0029-B0048
1418 — B0036 Potential roles of the
microglia and mononuclear cells interaction
in experimental autoimmune optic neuritis.
Ryusaku Matsuda1, T. Kezuka1, C. Nishiyama2, Y.
Usui1, Y. Matsunaga1, N. Yamakawa1, K. Okumura2,
H. Goto1. 1Ophthalmology, Tokyo Medical Univ
Hospital, Shinjuku-ku, Japan; 2Immunity, Juntendo
Atopy Research Center, Bunkyo-ku, Japan
Monday, May 06, 2013 8:30 AM-10:15 AM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
230 Optic Nerve: Mechanisms of
Damage and Neuroprotection in
Animal and in Vitro Models
Moderator: Kenneth S. Shindler
1411 — B0029 Molecular and histological
changes in the dLGN and cortices and their timecourse secondary to trans-synaptic degeneration
after optic nerve injury. Yuyi You1, V. Gupta1, A.
Klistorner1, 2, S. Graham1, 2. 1Macquarie University,
North Ryde, NSW, Australia; 2Sydney University,
Sydney, NSW, Australia
1412 — B0030 Nmnat3 inhibits up-regulation
of p62 in high IOP-induced optic nerve
degeneration. Yasushi Kitaoka, Y. Munemasa, K.
Kojima, S. Ueno. Ophthalmology, St. Marianna
University School of Medicine, Kawasaki, Japan
*CR
1413 — B0031 SIRT1 Delays RGC Loss
Following Optic Nerve Crush By Reducing
Oxidative Stress. Ling Zuo1, V. Lee2, R. S.
Khan2, K. E. Dine2, W. Wu2, K. S. Shindler2.
1
Second Hospital of Jilin University, Jilin, China;
2
Ophthalmology, University of Pennsylvania,
Scheie Eye Institute, Philadelphia, PA
1414 — B0032 Dexras1 Mediates Retinal
Ganglion Cell Loss Induced by NMDA
Excitotoxicity. Reas S. Khan1, Y. Chen2, A.
Cwanger1, Y. Song1, J. L. Dunaief1, S. F. Kim2, 3,
K. S. Shindler1. 1Ophthalmology, Univ of
Pennsylvania, Scheie Eye Inst, Philadelphia, PA;
2
Psychiatry, Center for Neurobiology and Behavior,
The Perelman School of Medicine University of
Pennsylvania, Philadelphia, PA; 3Pharmacology,
Center for Neurobiology and Behavior, The
Perelman School of Medicine University of
Pennsylvania, Philadelphia, PA *CR
1415 — B0033 Loss of the E3 ubiquitin ligase
Phr1 is Neuroprotective in Retinal Ganglion
Cells. Rachel Lamb, S. M. Culican. Ophthalmology,
Washington University in St. Louis, St. Louis, MO
1416 — B0034 Impact of plasma from
patients with neuromyelitis optica spectrum
disorders on the optic degeneration in rats.
Yoshiko Matsumoto1, A. Kanamori1, M. Nakamura1,
I. Nakashima2, A. Negi1. 1Department of
Ophthalmology, Kobe university graduate school of
medicine, Kobe, Japan; 2Department of Neurology,
Tohoku University Graduate School of Medicine,
Sendai, Japan
1419 — B0037 Induction of autophagy prevents
increase of p-PS1 in TNF-induced optic nerve
axonal degeneration. Kaori Kojima, Y. Kitaoka, Y.
Munemasa, S. Ueno. Ophthalmology, St Marianna
Univ School of Med, Kawasaki, Japan *CR
1420 — B0038 Neuroprotective effects of
recombinant human granulocyte colonystimulationg factor (G-CSF) in a rat model of
anterior ischemic optic neuropathy (rAION).
Rong-Kung Tsai. 1Dept of Ophthalmology, Tzu-Chi
Medical Center, Hualien, Taiwan; 2Department
of Ophthalmology and Visual Science, Tzu-Chi
University, Hualien, Taiwan
1421 — B0039 Syntaphilin is expressed in
astrocytes in optic nerve and is down regulated
in optic nerve after axonal injury. Akiko Miki, A.
Kanamori, M. Nakamura, Y. Matsumoto, A. Negi.
department of ophthalmology, Kobe University
graduate school of Medicine, Kobe, Japan
1422 — B0040 Time course of oligodendrocyte
death after rAION in Sprague Dawley rats. Zara
Mehrabyan, Y. Guo, S. L. Bernstein. University of
Maryland, Baltimore, Baltimore, MD
1423 — B0041 Post-ischemic Glial Response
in A Rodent Model of Non-Arteritic Anterior
Ischemic Optic Neuropathy. Shin Hae Park, J.
Choi, C. Joo. Department of Ophthalmology and
Visual Science, Seoul St.Mary’s Hospital, Catholic
University of Korea, Seoul, Republic of Korea
1424 — B0042 Peripapillary Edema Is
Associated with Nerve Fiber Layer Atrophy in a
Primate Model of Nonarteritic Anterior Ischemic
Optic Neuropathy. Mary A. Johnson1, N. R.
Miller2, S. L. Bernstein1, 3. 1Ophthal and Vis Science,
Univ of Maryland Sch of Medicine, Baltimore, MD;
2
Wilmer Ophthalmologic Institute, Johns Hopkins
Univ. Sch. of Medicine, Baltimore, MD; 3Anatomy
& Pathology, Univ. of Maryland Sch. of Medicine,
Baltimore, MD *CR
1425 — B0043 Severe Impairment of
Axonal Transport in Acute Experimental
Anterior Ischemic Optic Neuropathy. Jeffrey
Ma, M. Stanford, A. Shariati, G. Lee, Y. J. Liao.
Ophthalmology, Byers Eye Institute at Stanford,
Palo Alto, CA
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
124
Monday – Posters – 1426 – 1445
1426 — B0044 TLR4 knock-out mice are
resistant to optic nerve crush damage. Nitza
Goldenberg-Cohen1, 2, D. Morzaev2, 3, S. R. Weiss2, 3,
E. Hochhauser3, 4. 1Ophthalmology, Schneider
Children’s Medical Center, Petach Tiqwa,
Israel; 2The Krieger Eye Research Laboratory,
Felsenstein Medical Research Center, Tel Aviv
University, Petah Tiqwa, Israel; 3Sackler School
of Medicine, Tel Aviv University, Petah Tiqwa,
Israel; 4Laboratory of Cardiac Research, Felsenstein
Medical Research Center, Tel Aviv University,
Petach Tiqwa, Israel
1428 — B0046 Augmented Reality
Modification of Image Guided Endoscopic
Orbital Surgery Technique. Louise A. Mawn1,
M. P. DeLisi2, R. L. Galloway2. 1Vanderbilt Eye
Institute, Vanderbilt University, Nashville, TN;
2
Biomedical Engineering, Vanderbilt Univeristy,
Nashville, TN *CR
1429 — B0047 Evaluation of pharmacological
approaches to downregulation of pathogenic
gliotic response in the eye. Pavel Iserovich. Seleva
Ophthalmics LLC, Brooklyn, NY *CR
1430 — B0048 Characterisation of Olfactory
Mucosa for Olfactory Ensheathing Cell therapy
in optic nerve diseases. Maayke M. Kuijten1, 2,
A. Dahlmann-Noor1, S. Brocchini1, 2, P. T. Khaw1.
1
National Institute for Health Research (NIHR)
Biomedical Research Centre at Moorfields Eye
Hospital NHS Foundation Trust and UCL Institute
of Ophthalmology, London, United Kingdom; 2UCL
School of Pharmacy, London, United Kingdom *CR
Exhibit Hall B0158-B0190
Monday, May 06, 2013 8:30 AM-10:15 AM
Multidisciplinary Ophthalmic Imaging
231 Glaucoma and Optic
Neuropathies Imaging
Moderator: Ching-Yu Cheng
1431 — B0158 Optical Coherence Tomography
of the Optic Nerve: Comparison Between
Multiple Sclerosis and Neuromyelitis Optica.
Lucas Daniel A. Fernandes1, 2, P. A. Paixao1, 2, L. B.
Botelho Vergara1, 3, J. F. Araujo5, 1, E. C. Lacerda1, 3,
G. S. Souza1, 3, H. Souza Cabeça4, A. A. Rosa1, 6,
L. L. Silveira1, 3. 1Nucleo de Medicina Tropical,
Universidade Federal do Para, Belem, Brazil;
2
Instituto de Ciencias da Saude, Universidade
Federal do Para, Belem, Brazil; 3Instituto de
Ciencias Biologicas, Universidade Federal do
Para, Belem, Brazil; 4Hospital Ophir Loyola,
Belem, Brazil; 5Faculdade de Medicina, Centro
Universitario do Para, Belem, Brazil; 6Hospital
Universitario Bettina Ferro de Souza, Universidade
Federal do Para, Belem, Brazil
1433 — B0160 The assessment of retinal optical
properties in multiple sclerosis. Gabor Mark
Somfai1, E. Tatrai1, B. E. Varga1, K. Laurik1, M.
Simó2, D. DeBuc3. 1Department of Ophthalmology,
Semmelweis University, Budapest, Hungary;
2
Department of Neurology, Semmelweis University,
Budapest, Hungary; 3Bascom Palmer Eye Institute,
University of Miami, Miller School of Medicine,
Miami, FL *CR
1434 — B0161 In vivo microscopic inner
retinal phenotypes of retinal and neurologic
disease. Drew H. Scoles1, R. F. Cooper2, A. M.
Dubis3, B. P. Higgins4, J. Carroll4, 5, A. Dubra4, 6.
1
Biomedical Engineering, University of Rochester,
Rochester, NY; 2Biomedical Engineering, Marquette
University, Milwaukee, WI; 3Ophthalmology,
Duke University, Durham, NC; 4Ophthalmology,
Medical College of Wisconsin, Milwaukee, WI;
5
Cell Biology, Neurobiology and Anatomy, Medical
College of Wisconsin, Milwaukee, WI; 6Biophysics,
Medical College of Wisconsin, Milwaukee, WI *CR
1439 — B0166 Optical Coherence Tomography
imaging of Eyes with Optic Nerve Head Drusen.
Taku Sato1, 2, S. Mrejen1, 2, R. F. Spaide1, 2. 1Vitreous
Retina Macular Consultants of New York, New
York, NY; 2LuEsther T. Mertz Retinal Research
Center, Manhattan Eye, Ear, and Throat Hospital,
New York, NY *CR
1440 — B0167 Intraocular Pressure (IOP)
Elevation Reduces Schlemm’s Canal CrossSectional Area (SC-CSA) in Living Human Eyes.
Larry Kagemann1, 2, B. Wang1, 2, G. Wollstein1, H.
Ishikawa1, 2, Z. Nadler1, J. E. Nevins1, I. A. Sigal1, 2,
J. L. Grimm1, R. A. Bilonick1, 3, J. S. Schuman1, 2.
1
UPMC Eye Center, Eye and Ear Institute,
Ophthalmology and Visual Science Research
Center, Department of Ophthalmology, University
of Pittsburgh, Pittsburgh, PA; 2Department of
Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, PA;
3
Department of Biostatistics, Graduate School of
Public Health, University of Pittsburgh, Pittsburgh,
PA *CR
1441 — B0168 Enhanced depth optical
coherence tomography imaging of the
optic nerve canal in central retinal vein
occlusion. Hamid Hosseini, D. Rivera, G.
Heilweil, J. Hubschman, I. Tsui, S. D. Schwartz.
Ophthalmology, Jules Stein Eye Institute at UCLA,
Los Angeles, CA
1435 — B0162 Is retinal optical coherence
tomography an imaging biomarker for
Parkinson disease? Francisco J. Ascaso1, 2, B.
Jimenez1, J. López del Val3, 2, I. Pinilla Lozano1, 2, D.
Perez-Garcia1, J. Ibanez-Alperte1, J. A. Cristóbal1.
1
Ophthalmology, Univ Clinic Hosp “Lozano Blesa”,
Zaragoza, Spain; 2Aragon Health Sciences Insitute,
Zaragoza, Spain; 3Neurology, Universitiy Clinic
Hosptial “Lozano Blesa”, Zaragoza, Spain
1442 — B0169 A Comparison of Methods for
Correcting Ocular Magnification to Reduce
the Variance of Normal Retinal Nerve Fiber
Layer Thickness Measurements. Alyssa C.
Ehrlich1, D. W. Rhee1, A. S. Raza1, 2, T. Duncker3,
J. P. Greenberg3, V. C. Greenstein3, D. C. Hood1, 3.
1
Psychology, Columbia University, New York, NY;
2
Neurobiology and Behavior, Columbia University,
New York, NY; 3Ophthalmology, Columbia
University, New York, NY *CR
1436 — B0163 Retinal and peripapillary
nerve fiber layer thickness in eyes with thyroidassociated ophthalmopathy. Meira Neudorfer,
S. Blum, A. Kesler, D. Varssano, I. Leibovitch.
Department of Ophthalmology, Tel-Aviv Medical
Center, Tel Aviv, Israel *CR
1443 — B0170 Correlation between Visual
Field Defects and Perifoveal Ganglion Cells
Layer Thickness in Eyes Affected by Optic
Neuropathy. Andrea Coppe, G. Lapucci.
Fondazione Bietti per L’Oftalmologia IRCCS,
Rome, Italy
1437 — B0164 The Effect of Media Opacities
on Retinal Nerve Fiber Layer and Macular Inner
Retinal Layer Measurements with Spectral
Domain Optical Coherence Tomography. Stanley
Darma1, P. H. Kok1, M. D. Abramoff2, T. J. Van Den
Berg1, F. D. Verbraak1. 1Ophthalmology, Academic
Medical Center, Amsterdam, Netherlands;
2
Ophthalmology & Visual Sciences, University of
Iowa, Iowa City, IA *CR
1444 — B0171 Comparative assessment for
the ability of Cirrus, RTVue and 3D OCT to
diagnose glaucoma with high myopia. Akiyasu
Kanamori, A. Akashi, M. Nakamura, M. Fujihara,
Y. Yamada, A. Negi. Division of Ophthalmology,
Department of Surgery, Kobe University Graduate
School of Medicine, Kobe, Japan
1438 — B0165 Ganglion Cell Complex and
Retinal Nerve Fiber Layer Measurements in
Patients with Alzheimer’s Disease and Mild
Cognitive Impairment. Nataliya Semenova, V.
Akopyan, E. Gurova. Ophthalmology, Lomonosov
Moscow State University, Medical School, Moscow,
Russian Federation
1445 — B0172 iVue® iWellnessExam™ Retains
Highs Sensitivity & Specificity Among Novice
Reviewers. Samantha Slotnick1, 2, D. Epshtein1, C.
Awad1, S. Nath3, 4, J. Sherman1, 2. 1Clinical Science,
SUNY State College of Optometry, White Plains,
NY; 2SUNY Eye Institute, State University of New
York, NY, NY; 3Eye Institute and Laser Center, New
York, NY; 4NY Eye and Ear Infirmary, New York,
NY *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
125
Monday Posters
8:30 am – 10:15 am
1427 — B0045 Optic nerve and inner retina
damage after repeated mild traumatic brain
injury in a mouse model. Radouil T. Tzekov1, 2, A.
Ferro1, B. Mouzon1, D. Biggins1, R. C. Spinelli1, M.
Mullan1, M. Mullan1, F. Crawford1. 1The Roskamp
Institute, Sarasota, FL; 2Ophthalmology, University
of South Florida, Tampa, FL
1432 — B0159 Multimodal retinal imaging
in multiple sclerosis with and without optic
neuritis. Elisabetta Pilotto1, P. Gallo2, F. Guidolin1,
E. Convento1, M. Atzori2, M. Puthenparampil2,
R. Parrozzani3, 1, E. Midena1, 3. 1Department of
Ophthalmology, University of Padova, Padova,
Italy; 2Department of Neuroscience, University of
Padova, Padova, Italy; 3Fondazione G.B. Bietti per
l’Oftalmologia, IRCCS, Roma, Italy
Monday Posters
8:30 am – 10:15 am
1446 – 1467 – Monday – Posters
1446 — B0173 Analyzing Shape
Parameterization of SD-OCT Optic Nerve Head
Images in High Myopes as a Predictor of Visual
Field Defects. Sonny Sabhlok1, D. Russakoff2, T.
Johung1, J. D. Oakley2, F. Li3, K. Singh1, R. Chang1.
1
Stanford University, Stanford, CA; 2Voxeleron
LLC, Pleasanton, CA; 3Dept. of Ophthalmology and
Visual Sciences, Chinese University of Hong Kong,
Hong Kong, Hong Kong *CR
1454 — B0181 Indian Family Angle Closure
Evaluation Study - Comparison of IridotomyAssociated Anatomic Changes in Angle Closure
Suspects and Patients with Either Primary Angle
Closure or Primary Angle Closure Glaucoma.
Rengaraj Venkatesh1, P. Y. Ramulu2, S. Kavitha1,
P. Krishnamurthy1, D. S. Friedman2, H. Quigley2.
1
Glaucoma, Aravind Eye Hospital, Pondicherry,
India; 2Wilmer Eye Institute, Baltimore, MD *CR
1447 — B0174 Repeatability and
Reproducibility of iVue FD-OCT System. Yuanmu
Deng, K. A. Soules, D. Leung, W. Li, B. K. Jang, Q.
Zhou. Optovue, Inc, Fremont, CA *CR, f
1455 — B0182 Spectral Domain OCT in
Experimental Glaucoma. Carol A. Rasmussen1, 4,
K. B. McIntyre2, A. K. Goulding1, 4, C. D. Busse3,
J. J. Szurka3, A. L. Harvey3, J. N. Ver Hoeve1, 4, C.
J. Murphy5, 4, B. J. Christian3, T. Nork1, 4. 1School
of Medicine and Public Health, University of
Wisconsin, Madison, WI; 2Comparative Ophthalmic
Research Laboratories, Madison, WI; 3Covance
Laboratories, Madison, WI; 4OSOD (Ocular
Services On Demand, LLC), Madison, WI;
5
Surgical and Radiological Sciences, University of
California, Davis, CA *CR
1448 — B0175 Scanning Laser Polarimetry as a
Complement to Optical Coherence Tomography
in Multiple Sclerosis. Jessica E. Chan1, D. Feller3,
S. L. Galetta2, L. Balcer2. 1Ophthalmology, New
York University, New York, NY; 2Neurology,
New York University, New York, NY; 3Haverford
College, Haverford, PA *CR
1449 — B0176 Influence of Automated Disc
Margin Determination on Stratus OCT Optic
Nerve Head Measurements. Ivan M. Tavares, A. S.
Camargo, F. E. Hirai, L. S. Melo. Ophthalmology,
Federal University of Sao Paulo, Sao Paulo, Brazil
1450 — B0177 Correction of the Retinal Angle
in SD-OCT of Glaucomatous Eyes Provides
Better Reproducibility of Optic Nerve Head
Parameters. Kyungmoo Lee1, Y. H. Kwon2, M.
D. Abramoff2, 3, M. K. Garvin3, 1, M. Sonka1, 2.
1
Electrical and Computer Engineering, University
of Iowa, Iowa City, IA; 2Ophthalmology and
Visual Sciences, University of Iowa, Iowa City, IA;
3
Veterans Affairs, Iowa City VA Medical Center,
Iowa City, IA *CR
1451 — B0178 Imaging retinal nerve fiber
loss in glaucoma using adaptive optics scanning
laser ophthalmoscopy. Gang Huang, T. Gast, T.
Luo, T. Y. Chui, W. H. Swanson, V. Malinovsky, S.
A. Burns. Optometry School, Indiana University,
Bloomington, IN
1452 — B0179 Imaging of optic nerve head
pore structure with motion corrected deeply
penetrating OCT using tracking SLO. Kari V.
Vienola1, B. Braaf1, C. K. Sheehy2, Q. Yang3, P.
Tiruveedhula2, D. W. Arathorn3, J. F. de Boer1, 4,
A. Roorda2. 1Rotterdam Ophthalmic Institute,
Rotterdam, Netherlands; 2School of Optometry,
University of California, Berkeley, CA; 3Montana
State University, Bozeman, MT; 4LaserLAB,
Department of Physics and Astronomy, VU
University, Amsterdam, Netherlands *CR
1453 — B0180 Ocular Biometries Using
Spectral Domain Optical Coherence
Tomography in Children with Large Cupping.
Ungsoo Kim, J. Jung, S. Baek. Ophthalmology,
Kim’s Eye Hospital, Konyang University, Seoul,
Republic of Korea
1462 — B0189 Comparison of coupled level sets
and graph cuts for retinal layer segmentation in
optical coherence tomography. Jelena Novosel1, 2,
M. Ostermann2, G. Thepass1, H. G. Lemij3, K. A.
Vermeer1, L. J. van Vliet2. 1Rotterdam Ophthalmic
Institute, Rotterdam Eye Hospital, Rotterdam,
Netherlands; 2Quantitative Imaging Group, Faculty
of Applied Science, Delft University of Technology,
Delft, Netherlands; 3Glaucoma Service, Rotterdam
Eye Hospital, Rotterdam, Netherlands *CR
1463 — B0190 Logistic Regression Model
for Principal Factor Analysis Combining
Spectral Domain OCT Structural Parameters
for Detection of Early Glaucoma. JeanClaude Mwanza1, J. Warren2, D. L. Budenz1.
1
Ophthalmology, University of North Carolina
at Chapel Hill, Chapel Hill, NC; 2Biostatistics,
University of North Carolina at Chapel Hill, Chapel
Hill, NC
1456 — B0183 Choroidal thickness in
glaucoma and diabetic patients with good visual
acuity. Gloria Wu1, A. Tran2, S. Young3, E. Chen4, V.
Nam2, A. Gupta1, J. Xu2, S. M. Hailpern5. 1Stanford
University School of Medicine, Palo Alto, CA; 2UC
Berkeley, Berkeley, CA; 3UC Irvine, Irvine, CA;
4
University of British Columbia, Vancouver, BC,
Canada; 5Independent Epidemiology Consultant,
Saratoga, CA
Exhibit Hall B0191-B0243
1457 — B0184 Diagnostic Validity of Macular
Ganglion Cell-Inner Plexiform Layer Thickness
Deviation Map Using Spectral Domain Optical
Coherence Tomography in Preperimetric
and Early Glaucoma. Sang Woo Park, J. Choi.
Department of Ophthalmology, Chonnam National
University Medical School & Hospital, Gwangju,
Republic of Korea
Moderators: Christoph K. Hitzenberger and
John S. Werner
1458 — B0185 Investigation of the retinal
thickness using Spectralis OCT® reveals a
significant decrease after short time elevation of
IOP. Julia Teister, O. W. Gramlich, T. Lueckner, M.
Kriechbaum, N. Pfeiffer, F. H. Grus. Experminental
Ophthalmology, Department of Ophthalmology,
University Medical Center, Mainz, Mainz, Germany
*CR
1459 — B0186 Relationship between Retinal
Vascular Parameters and Optic Nerve/ Ganglion
Cell-Inner Plexiform Layer Parameters in NonGlaucomatous Eyes. Yih Chung Tham1, 2, T. Y.
Wong2, 1, T. Aung2, 1, C. Cheng1, 2, C. Y. Cheung2, 1.
1
School of Medicine (Ophthalmology), National
University of Singapore, National University Health
System, Singapore, Singapore; 2Singapore Eye
Research Institute, Singapore National Eye Centre,
Singapore, Singapore *CR
1460 — B0187 retinal nerve fiber layer defect
and its associations in Adult Chinese Population.
Ya Xing Wang1, L. Zhao1, J. B. Jonas2, 1, L. Xu1.
1
Beijing Tongren Hospital, Beijing Institute of
Ophthalmology, Beijing, China; 2Medical Faculty
Mannheim-Heidelberg, Mannheim, Germany *CR
1461 — B0188 The Use of Handheld Optical
Coherence Tomography in Urban Community
Eye Screening. James Lin, P. Patel, B. Szirth, A.
S. Khouri. UMDNJ- New Jersey Medical School,
Newark, NJ *CR
Monday, May 06, 2013 8:30 AM-10:15 AM
Multidisciplinary Ophthalmic Imaging /
Visual Neuroscience
232 Advancement in Imaging
Technologies
1464 — B0191 Structured illumination
ophthalmoscope for high-resolution fluorescence
imaging of retinal pigment epithelium.
Stefan Dithmar1, G. Best1, 2, S. Rossberger1, 2, T.
Ach1, 4, S. Pollithy1, C. Cremer2, 3. 1Department
of Ophthalmology, University of Heidelberg,
Heidelberg, Germany; 2Kirchhoff Institute for
Physics, University of Heidelberg, Heidelberg,
Germany; 3Institute of Molecular Biology,
University of Mainz, Mainz, Germany; 4Department
of Ophthalmology, University of Alabama,
Birmingham, AL
1465 — B0192 Low-cost 3D Retinal Imaging
using Structured Illumination. Steve Gruppetta,
S. Chetty. Optometry and Visual Science, City
University London, London, United Kingdom *CR
1466 — B0193 Spectral OCT with novel
speckle reduction technique for evaluation of the
healing process after PRK and transepithelial
PRK. Maciej Wojtkowski1, B. J. Kaluzny2, D.
Bukowska1, M. Szkulmowski1. 1Department of
Physics, Astronomy and Informatics, Instytute of
Physics, Nicolaus Copernicus University, Torun,
Poland; 2Department of Ophthalmology, Collegium
Medicum, Nicolaus Copernicus University, Torun,
Poland *CR
1467 — B0194 Phase retardation changes of
Henle’s fiber layer associated with aging. Qiang
Wang1, B. Cense2, O. P. Kocaoglu1, Z. Liu1, D. T.
Miller1. 1School of Optometry, Indiana University,
Bloomington, IN; 2Center of Optical Research and
Education, Utsunomiya University, Utsunomiya,
Japan *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
126
Monday – Posters – 1468 – 1489
1468 — B0195 Phase Retardation Asymmetry
Associated with the Henle Fiber Layer in Normal
Aging. Dean A. VanNasdale1, A. E. Elsner2, C. A.
Clark2, S. A. Burns2. 1Optometry, The Ohio State
University College of Optometry, Columbus,
OH; 2School of Optometry, Indiana University,
Bloomington, IN *CR
1469 — B0196 Feasability of ultrawide-field
retinal-shape measurement with MHz-OCT.
Wolfgang Wieser1, T. Klein1, A. S. Neubauer2, L.
Reznicek2, A. Kampik2, R. Huber1. 1Faculty of
Physics, Ludwig-Maximilians-University, Munich,
Germany; 2Ophthalmology, Ludwig-MaximiliansUniversity, Munich, Germany
1471 — B0198 Characteristics of the Retinal
Pigment Epithelium in Patients with Albinism
using Wide-field Polarization-sensitive Optical
Coherence Tomography. Christopher Schuetze1,
M. Bolz1, M. Ritter1, R. Blum1, S. Zotter2, B.
Baumann2, M. Pircher2, E. Gotzinger2, C. K.
Hitzenberger2, U. Schmidt-Erfurth1. 1Department
of Ophthalmology, Medical University of Vienna,
Vienna, Austria; 2Medical Physics and Biomedical
engineering, Medical University of VIenna, Vienna,
Austria *CR
1472 — B0199 In Vivo Phase Retardation
Measurements of Deposits in Bruch’s Membrane
with Polarization-Sensitive Optical Coherence
Tomography. Barry Cense1, Q. Wang2, D. T.
Miller2, J. A. Papay2, A. E. Elsner2. 1Center for
Optical Research & Education, Utsunomiya
University, Utsunomiya, Japan; 2School of
Optometry, Indiana University, Bloomington, IN
*CR
1473 — B0200 Analysis of partial and
complete sparing of the Fovea in patients with
Geograpic Atrophy by Polarization-Sensitive
Optical Coherence Tomography. Ramzi G.
Sayegh1, S. Zotter2, P. K. Roberts1, M. Bolz1,
C. G. Kiss1, M. Baratsits1, B. Baumann2, M.
Pircher2, C. K. Hitzenberger2, U. Schmidt-Erfurth1.
1
Ophthalmology, Medical University of Vienna,
Vienna, Austria; 2Center for Medical Physics and
Biomedical Engineering, Medical University of
Vienna, Vienna, Austria *CR
1474 — B0201 Investigation of the ChoroidSclera Interface and Choroidal Thickness
in 3D Polarization Sensitive OCT Images of
the Human Eye. Teresa Torzicky, S. Zotter, M.
Pircher, B. Baumann, C. K. Hitzenberger. Medical
University of Vienna, Vienna, Austria *CR
1475 — B0202 Polarization Sensitive Optical
Coherence Tomography with Retinal Tracking
and Frame averaging. Mitsuro Sugita1, 2, S. Zotter1,
M. Pircher1, T. Makihira2, K. Saito2, N. Tomatsu2,
C. K. Hitzenberger1. 1Center for Medical Physics
and Biomedical Engineering, Medical University of
Vienna, Vienna, Austria; 2Canon Inc., Tokyo, Japan
*CR
1477 — B0204 Characteristic findings of
retinitis pigmentosa in polarization sensitive
optical coherence tomography. Karin Kofler1, M.
Bolz1, B. Baumann2, S. Zotter2, F. G. Schlanitz1,
P. K. Roberts1, M. Pircher2, M. Ritter1, C. K.
Hitzenberger2, U. Schmidt-Erfurth1. 1Dep. of
Ophthalmology and Optometrie, Medical University
of Vienna, Vienna, Austria; 2Center for Medical
Physics and Biomedical Engineering, Medical
University of Vienna, Vienna, Austria *CR
1478 — B0205 Cross polarization kit to
enhance slit lamp fundoscopy. Ken Tran1, 2, T. A.
Mendel2, 3, K. Holbrook2, P. A. Yates2. 1Biomedical
Engineering, University of Virginia, Burke, VA;
2
Department of Ophthalmology, University of
Virginia, Charlottesville, VA; 3Pathology, University
of Virginia, Charlottesville, VA *CR
1479 — B0206 Retinal and choroidal imaging
with 870 nm spectral domain OCT compared to
1050 nm spectral domain OCT, with and without
enhanced depth imaging. Elizabeth Verner-Cole,
J. P. Campbell, T. S. Hwang, M. L. Klein, S. Bailey.
Casey Eye Institute, Portland, OR
1480 — B0207 Choroidal imaging in gasfilled eye using swept source optical coherence
tomography. Ichiro Maruko1, Y. Sugano1, H.
Oyamada1, T. Sekiryu1, T. Iida2, M. Akiba3.
1
Ophthalmology, Fukushima Medical University,
Fukushima, Japan; 2Ophthalmology, Tokyo
Women’s Medical University, Tokyo, Japan;
3
Topcon corporation, Tokyo, Japan *CR
1481 — B0208 En Face Visualization of the
Retinal Pigment Epithelium and Choroid in
Chorioretinal Diseases using Swept-Source
Optical Coherence Tomography. Kathrin J.
Mohler1, 2, D. Ferrara3, M. Adhi3, J. J. Liu1, I.
Grulkowski1, M. F. Kraus1, 4, C. D. Lu1, J. M.
Hornegger4, J. S. Duker3, J. G. Fujimoto1. 1Research
Lab of Electronics/ Electrical Engineering and
Computer Science, Massachusetts Institute of
Technology, Cambridge, MA; 2Faculty of Physics,
Ludwig-Maximilians-University Munich, Munich,
Germany; 3New England Eye Center, Tufts
University, Boston, MA; 4Pattern Recognition
Lab and Graduate School in Advanced Optical
Technologies, University Erlangen-Nuremburg,
Erlangen-Nuremburg, Germany *CR
1482 — B0209 Swept source optical coherence
tomography in eyes with macular hemorrhage.
Hiroshi Oyamada1, I. Maruko1, Y. Sugano1, T.
Sekiryu1, T. Iida2. 1Fukushima Medical University,
Fukushima, Japan; 2Ophthalmology, Tokyo
Women’s Medical University, Tokyo, Japan
1483 — B0210 Measurement of light reflection
and scatter from eyes. Mikhail Levin, M. A.
Campos, A. Dennison, P. De Guzman, A. Malek
Tabrizi, H. Fu. Abbott Medical Optics, Santa Ana,
CA *CR
1484 — B0211 Functional Optical Coherence
Tomography with a Commercial Device - A Pilot
Study. Michel M. Teussink1, M. van Grinsven2, R. A.
van Huet1, B. Cense3, C. B. Hoyng1, B. Klevering1,
T. Theelen1. 1Ophthalmology, Radboud University
Nijmegen Medical Centre, Nijmegen, Netherlands;
2
Radiology, Radboud University Nijmegen Medical
Centre, Nijmegen, Netherlands; 3Center of Optical
Research and Education, Utsunomiya University,
Utsunomiya, Japan *CR
1485 — B0212 Focused ion beam sectioning
retinal pigment epithelium cells. Po-Kang
Lin2, 1, C. Kuan2. 1National Yang Ming University/
Taipei VGH, Taipei, Taiwan; 2Graduate Institute
of Biomedical Electronics and Bioinformatics,
National Taiwan University, Taipei, Taiwan
1486 — B0213 Characterization of lipids in
human meibomian gland using coherent Raman
scattering microscopy. Jeffrey Suhalim1, Y. Xie2,
J. Tao2, D. J. Brown2, J. V. Jester2, E. Potma1.
1
Beckman Laser Institute, University of California,
Irvine, Irvine, CA; 2Gavin Herbert Eye Institute,
University of California, Irvine, Irvine, CA
1487 — B0214 Handheld MEMS-based
Optical Coherence Tomography in Anterior
and Posterior Segment Diagnosis. Samir I.
Sayegh1, J. N. Taibl1, W. Jung3, D. McCormick4,
R. Shelton2, R. Nolan2, S. A. Boppart2. 1Anterior
Segment & Vitreoretinal Surg, The Eye Center/
The Retina Center, Champaign, IL; 2Beckman
Institute for Advanced Science and Technology,
University of Illinois, Champaign, IL; 3School
of Nano-Bioscience and Chemical Engineering,
Ulsan National Institute of Science and Technology
(UNIST) School of Nano-Bioscience and
Chemical Engineering, Ulsan, Republic of Korea;
4
AdvancedMEMS, San Francisco, USA Minor
Outlying Islands *CR
1488 — B0215 Handheld Combined SLO/
OCT System. Francesco LaRocca1, D. Nankivil1,
A. Dhalla1, R. P. McNabb1, C. A. Toth2, S. Farsiu2, 1,
J. A. Izatt1, 2. 1Biomedical Engineering, Duke
University, Durham, NC; 2Ophthalmology, Duke
University, Durham, NC *CR
1489 — B0216 Handheld High Speed 500
kHz Swept Source OCT Device Using a Micro
Scanning Mirror. Chen D. Lu1, M. F. Kraus1, 2, I.
Grulkowski1, J. J. Liu1, B. Potsaid1, 3, V. Jayaraman4,
A. E. Cable3, J. M. Hornegger2, J. S. Duker5, J. G.
Fujimoto1. 1Research Laboratory of Electronics,
Massachusetts Institute of Technology, Cambridge,
MA; 2Pattern Recognition Lab and School of
Advanced Optical Technologies, University
Erlangen Nuremberg, Erlangen, Germany;
3
Advanced Imaging Group, Thorlabs, Inc., Newton,
NJ; 4Praevium Research, Santa Barbra, CA;
5
Ophthalmology, New England Eye Center, Boston,
MA *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
127
Monday Posters
8:30 am – 10:15 am
1470 — B0197 MultiImaging Using the Ultra
Widefield Retinal Imaging Device for Fundus
Screening. Satoshi Ishiko1, H. Kagokawa2, A.
Takamiya2, E. Sato2, K. Sugawara2, A. Yoshida2.
1
Medicine and Engineering Comb Res Inst,
Asahikawa Medical University, Asahikawa, Japan;
2
Ophthalmology, Asahikawa Medical University,
Asahikawa, Japan
1476 — B0203 Characterization of Stargardt
disease using polarisation-sensitive spectraldomain optical coherence tomography and
fundus autofluorescence imaging. Markus Ritter1,
S. Zotter2, G. Deak1, M. Pircher2, S. Sacu1, C. K.
Hitzenberger2, U. Schmidt-Erfurth1. 1Department
of Ophthalmology, Medical University of Vienna,
Vienna, Austria; 2Center for Medical Physics and
Biomedical Engineering, Medical University of
Vienna, Vienna, Austria *CR
1490 – 1590 – Monday – Posters
Monday Posters
8:30 am – 10:15 am
1490 — B0217 Application of Raman
Spectroscopy to Detect Retinoblastoma Tumor
Viability. Olena Y. Palyvoda1, 2, J. Roarty2.
1
Electrical and Computer Engineering, Wayne State
University, Detroit, MI; 2Ophthalmology, Wayne
State University School of Medicine, Detroit, MI
1491 — B0218 VCSEL Laser Technology for
Ultrahigh Speed and Extended Depth Range
OCT Imaging of the Retina and Anterior
Eye. Benjamin Potsaid1, 2, J. J. Liu1, W. Choi1,
I. Grulkowski1, V. Jayaraman3, J. Y. Jiang2, P. J.
Heim2, J. S. Duker4, A. E. Cable2, J. G. Fujimoto1.
1
Department of Electrical Engineering and
Computer Science, and Research Laboratory of
Electronics, Massachusetts Instiute of Technology,
Cambridge, MA; 2Advanced Imaging Group,
Thorlabs, Newton, NJ; 3Praevium Research Inc.,
Santa Barbara, CA; 4New England Eye Center and
Tufts Medical Center, Tufts University, Boston, MA
*CR
1492 — B0219 Ultrahigh speed polarization
sensitive OCT of the anterior and posterior eye
using a 1050 nm VCSEL light source. Al-Hafeez
Dhalla1, 2, J. J. Liu1, K. J. Mohler1, B. Potsaid1, 3,
C. D. Lu1, V. Jayaraman4, A. E. Cable3, D.
Huang5, J. G. Fujimoto1. 1Department of Electrical
Engineering and Computer Science, and Research
Laboratory of Electronics, MIT, Cambridge, MA;
2
Ophthalmology, New England Eye Center and
Tufts Medical Center, Boston, MA; 3Advanced
Imaging Group, Thorlabs, Newton, NJ; 4Praevium
Research, Inc., Santa Barbara, CA; 5Casey Eye
Institute, Oregon Health & Science University,
Portland, OR *CR
1493 — B0220 Photoacoustic ophthalmoscopy
guided by real-time fundus camera. Hao F.
Zhang1, 2, S. Jiao3, T. Liu1, W. Song1. 1Biomedical
Engineering, Northwestern University, Evanston,
IL; 2Ophthalmology, Northwestern University,
Evanston, IL; 3Biomedical Engineering, Florida
International University, Miami, FL *CR
1494 — B0221 Pump-Probe Laser Imaging of
Pigment in Conjunctival Melanocytic Lesions.
Prithvi Mruthyunjaya1, L. Vajzovic1, J. W. Wilson2,
F. E. Robles2, T. J. Cummings1, W. S. Warren2.
1
Duke University Eye Center, Durham, NC; 2Duke
University, Durham, NC
1495 — B0222 A Novel Technique for
Combined Retinal and Choroidal Imaging
Using Optical Coherence Tomography. Matthew
Richardson, R. Mathew, S. Sivaprasad. Kings
College Hospital, London, United Kingdom *CR
1496 — B0223 Modification of Spectralis
HRA + OCT for intraoperative multi-modality
imaging in pediatric retinal diseases. Timothy
Fung, M. M. Muqit, D. Mordant, L. Smith, C. K.
Patel. Vitreoretinal, Oxford Eye Hospital, Oxford,
United Kingdom
1497 — B0224 Scale- and rotation-invariant
fundus tracking system for noninvasive OCT
retinal micro-capillary network visualization and
retinal disease progression OCT measurements.
Dawid Borycki1, M. Szkulmowski1, D. Ruminski1,
D. Bukowska1, B. L. Sikorski1, 2, I. Gorczynska1, A.
Kowalczyk1, M. Wojtkowski1. 1Institute of Physics,
Faculty of Physics, Astronomy and Informatics,
Nicolaus Copernicus University, Torun, Poland;
2
Department of Ophthalmology, Collegium
Medicum, Nicolaus Copernicus University,
Bydgoszcz, Poland
1498 — B0225 Automatic axial biometry
of the whole eye using ultra-long scan depth
optical coherence tomography. Jianguang
Zhong1, 2, Y. Shao1, 3, A. Tao1, 3, H. Jiang1, C. Liu4, J.
Wang1. 1Bascom Palmer Eye Institute, Miami, FL;
2
Ophthalmology, Hangzhou First people’s Hospital,
Hangzhou, China; 3School of Ophthalmology and
Optometry, Wenzhou Medical College, Wenzhou,
China; 4Department of Biomedical Engineering,
University of Miami, Miami, FL *CR
1499 — B0226 Cost-Effective Active Retinal
Tracker to Stabilize Eye Motions in Optical
Coherence Tomography. Yiheng Lim1, R. de
Kinkelder2, B. Cense1. 1Center for Optical Research
& Education, Utsunomiya University, Utsunomiya,
Japan; 2University of Amsterdam, Amsterdam,
Netherlands *CR
1500 — B0227 Quantification of local
hemoglobin oxygen saturation by 800 nm
Dual-Window Spectroscopic OCT. Roman V.
Kuranov1, 2, C. Oian3, G. Noojin4, K. Schuster4,
A. D. Shingledecker4, D. J. Stolarski4, J. Oliver5.
1
Systems Division, Wasatch Photonics, Durham,
NC; 2Ophthalmology, UT Health Science Center
San Antonio, San Antonio, TX; 3Mechanical
Engineering, UT San Antonio, San Antonio, TX;
4
TASC, San Antonio, TX; 5Air Force Research
Laboratory, Ft. Sam Houston, TX *CR
1501 — B0228 High Three-Dimensional
Resolution and Long Imaging Range Retinal
Optical Frequency Domain Imaging using
Dual-Axicon Lens Illumination. Jongshin Kim1, 2,
Y. Kim1, J. Ahn3, 4, S. Woo3, 5, K. Park3, 5, W. Oh1.
1
Department of Mechanical Engineering, KAIST,
Daejeon, Republic of Korea; 2Graduate School of
Medical Science and Engineering, KAIST, Daejeon,
Republic of Korea; 3Department of Ophthalmology,
Seoul National University College of Medicine,
Seoul, Republic of Korea; 4Department of
Ophthalmology, SMG-SNU Boramae Medical
Center, Seoul, Republic of Korea; 5Department of
Ophthalmology, Seoul National University Bundang
Hospital, Seoul, Republic of Korea
1504 — B0231 Slit-Lamp Adapted UltraHigh Resolution OCT for Imaging of the
Retinal Neural Tissue Structure and Vascular
Morphology. Delia DeBuc, O. M. Nomir, H. Jiang,
J. Wang. Ophthalmology, University of Miami,
Miami, FL *CR
1505 — B0232 Features of Cone
Photoreceptors on Adaptive Optics Retinal
Imaging. Manickam N. Muthiah1, 2, C. Gias2,
J. Zhong1, Z. McClelland1, P. J. Coffey2, L.
daCruz1, 2. 1Vitreoretinal Research, Moorfields
Eye Hospital, NIHR Biomedical Research Centre
for Ophthalmology, London, United Kingdom;
2
Division of Cellular Therapy, UCL Institute of
Ophthalmology, NIHR Biomedical Research Centre
for Ophthalmology, London, United Kingdom *CR
1506 — B0233 Comparison of the multifocal
electroretinogram (mfERG) a-wave amplitude
and cone density. Michael Klein, S. Viswanathan,
S. A. Burns, G. Huang. Indiana University,
Bloomington, IN
1507 — B0234 A New Retinal
Lesion:Characterization of the Gliotic Lesion, or
Gli, by Review of AOSLO and SDOCT Images
from 851 Subjects. Thomas Gast, T. Y. Chui, W. H.
Swanson, A. E. Elsner, J. A. Papay, S. A. Burns. IU
School of Optometry, Bloomington, IN *CR
1508 — B0235 Adaptive optics enhanced SLO/
OCT imaging of human photoreceptors with
axial eye tracking. Michael Pircher1, F. Felberer1,
J. S. Kroisamer2, 1, B. Baumann1, S. Zotter1, U.
Schmidt-Erfurth2, C. K. Hitzenberger1. 1Center
for Med Pyhs & Biomed Eng, Medical University
of Vienna, Vienna, Austria; 2Department of
Ophthalmology and Optometry, Medical University
of Vienna, Vienna, Austria *CR
1509 — B0236 Characterizing foveal
specialization in albinism using AOSLO and
SD-OCT. Melissa A. Wilk1, J. T. McAllister2,
T. Patitucci1, A. M. Dubis3, K. E. Stepien2, W.
Wirostko2, D. M. Costakos2, C. G. Summers4,
M. Brilliant5, J. Carroll1, 2. 1Cell Biology,
Neurobiology, & Anatomy, Medical College of
Wisconsin, Milwaukee, WI; 2Ophthalmology,
Medical College of Wisconsin, Milwaukee, WI;
3
Ophthalmology, Duke University Eye Center,
Durham, NC; 4Ophthalmology, University of
Minnesota, Minneapolis, MN; 5Center for Human
Genetics, Marshfield Clinic, Marshfield, WI *CR
1502 — B0229 A Robotic-controlled
Intraocular OCT Probe. Jin H. Shen1, H.
Yu2, N. Simaan2, K. M. Joos1. 1Ophthalmology,
Vanderbilt University, Nashville, TN; 2Mechanical
Engineering, Vanderbilt University, Nashville, TN
*CR
1503 — B0230 Retinal Imaging Using a
25-gauge OCT Endoprobe through Vitreous and
Vitreous Substitutes. Anita Agarwal, J. H. Shen,
K. M. Joos. Ophthalmology, Vanderbilt University,
Nashville, TN *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
128
Monday – Posters – 1510 – 1530
1511 — B0238 Improved cellular resolution
retinal imaging with aberration free and pupil
wander free reflective Adaptive Optics - Optical
Coherence Tomography Imaging System. Sang
Hyuck Lee1, Y. Jian2, R. J. Zawadzki1, J. S. Werner1.
1
Ophthalmology & Vision Science, UC Davis
Medical Center, Sacramento, CA; 2Engineering
Science, Simon FraserUniversity, Burnaby, BC,
Canada
1512 — B0239 Adaptive optics imaging of
eyes with epiretinal membrane before and
after surgery. Fabio Scarinci1, G. Ripandelli1,
G. Cupo1, M. Pileri2, S. Serrao1, M. Lombardo1.
1
Ophthalmology, IRCCS - “Fondazione G.B.
Bietti”, Rome, Italy; 2Ophthalmology, San Giovanni
Addolorata hospital, Rome, Italy
1513 — B0240 Adaptive optics and
psychophysical measures for anatomical and
functional cone patterns association in normal
subjects. Ieva Sliesoraityte, S. Mohand-Said, V.
Ganem, J. A. Sahel. Institut de la Vision, Paris,
France *CR
1514 — B0241 Photoreceptor deflection around
subretinal drusenoid deposits (SDD) revealed by
adaptive optics scanning laser ophthalmoscopy
(AOSLO). Yuhua Zhang1, X. Wang1, E. Blanco1, 2,
M. Clark1, C. D. Witherspoon1, C. A. Girkin1, C.
Owsley1, C. A. Curcio1. 1Ophthalmology, Univ
of Alabama at Birmingham, Birmingham, AL;
2
BioMedical Engineering, University of Alabama at
Birmingham, Birmingham, AL *CR
1515 — B0242 Improved visualization of
optical coherence tomography (OCT) image
using line-divided pattern matching technique.
Naoki Kobayashi, T. Nakagawa, T. Suzuki, S.
Toyoda. Life Science Division, Kowa company,
Ltd., Hamamatsu, Japan *CR
1516 — B0243 A fast auto-focus for digital slit
lamp imaging. Tobias Rudolph1, 2, S. Wyder1, 2, S. I.
De Zanet1, 2, S. Wolf2, J. H. Kowal1, 2. 1Ophthalmic
Technologies ARTORG Center, University of Bern,
Bern, Switzerland; 2Department of Ophthalmology,
University of Bern, Bern, Switzerland *CR
Exhibit Hall B0303-B0315
Monday, May 06, 2013 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics
233 Binocular Vision and Age Effects
on Vision
Moderator: Allen M. Cheong
1517 — B0303 Oblique effects in V2 neurons
of infant macaque monkeys. Xiaofeng Tao1, B.
Zhang1, 2, G. Shen1, E. L. Smith1, Y. M. Chino1.
1
College of Optometry, Unitersity of Houston,
Houston, TX; 2College of Optometry, NOVA
Southeastern University, Fort Lauderdale, FL *CR
1518 — B0304 Interocular acuity differences
alter the spatial frequency tuning of stereopsis.
Ashley Craven1, T. Tran1, K. Gustafson1, T. H.
Wu1, K. So1, D. M. Levi1, 2, R. W. Li1, 2. 1School of
Optometry, University of California-Berkeley,
Berkeley, CA; 2Helen Wills Neuroscience Institute,
University of California-Berkeley, Berkeley, CA
1519 — B0305 Enhancing stereoacuity through
perceptual learning in normal vision: Specificity
for spatial frequency and orientation. Truyet
Tran1, K. So1, C. Nguyen1, T. Leung3, S. Chat1,
D. M. Levi1, 2, R. W. Li1, 2. 1School of Optometry,
University of California-Berkeley, Berkeley, CA;
2
Helen Wills Neuroscience Institute, University
of California-Berkeley, Berkeley, CA; 3School of
Optometry, The Hong Kong Polytechnic University,
Hung Hom, Hong Kong
1520 — B0306 Factors influencing stereoacuity
levels after surgery to correct unilateral
developmental cataracts in children. Soo Jung
Lee1, N. Kim2, J. Park2. 1Haeundae Paik Hospital,
Busan, Republic of Korea; 2Ophthalmology,
Maryknoll Medical Center, Busan, Republic of
Korea
1521 — B0307 Do Bangerter filters promote
binocular function in amblyopes? Daming Deng1,
J. LI1, 2, B. Thompson3, M. Yu1, 2, R. F. Hess4. 1State
Key Laboratory of Ophthalmology, Zhongshan
Ophthalmic Center, Sun Yat-sen University,
Guangzhou, China; 2Department of Optometry and
Vision Science, Sun Yat-sen University, Guangzhou,
China; 3Department of Optometry and Vision
Science, University of Auckland, Auckland, New
Zealand; 4Department of Ophthalmology, McGill
University, Montreal, QC, Canada *CR
1522 — B0308 Optimizing binocular vision of
pseudophakes with uncorrected astigmatism.
Veerendranath Pesala1, P. Garg2, S. R. Bharadwaj1.
1
Prof. Brien Holden Eye Research Centre, L V
Prasad Eye Institute, Hyderabad, India; 2Cornea and
anterior segment services, L V Prasad Eye Institute,
Hyderabad, India
1523 — B0309 Effects of refractive blur and
clothing on night-time pedestrian visibility.
Joanne M. Wood, R. Marszalek, T. Carberry, P.
Lacherez, S. Virupaksha, M. J. Collins. School
of Optometry and Vision Science, Queensland
University of Technology, Brisbane, QLD, Australia
1524 — B0310 Pupil Changes under Scotopic
and Photopic illumination. Li Chen, D. Chernyak.
AMO Development, LLC, Milpitas, CA *CR
1525 — B0311 The Correlation between Visual
Acuity, Refraction and Cognitive Function in
the Elderly. Oriel Spierer1, N. Fischer1, A. Barak1,
M. Belkin2. 1Ophthalmology, Tel Aviv Sourasky
Medical Center, Tel Aviv, Israel; 2Ophthalmic
Technologies Laboratory, Goldschleger Eye
Research Institute, Tel Aviv University, Tel
Hashomer, Israel *CR
1526 — B0312 Relationship between dynamic
vision and balance in older adults. Allen M.
Cheong1, K. Siong1, W. Tsang2, 3, H. Chan1, 3.
1
School of Optometry, Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong;
2
Department of Rehabilitation Sciences, The Hong
Kong Polytechnic University, Hung Hom, Hong
Kong; 3Institute of Active Ageing, Faculty of Health
and Social Sciences, The Hong Kong Polytechnic
University, Hung Hom, Hong Kong
1527 — B0313 Effect of Visual Function on
Giving and Receiving Help in an Older Adult
Population. Monique J. Leys1, P. Jain1, M. Smith2,
G. Miller1, K. B. Mitchell1, J. V. Odom1. 1WVU Eye
Institute, Morgantown, WV; 2Psychology, WVU,
Madison, WI
1528 — B0314 Online Assessment of Contrast
Sensitivity and Hallucinations in Parkinson’s
Disease. Mary Lou Jackson1, J. Wallis1, P.
Wicks2, P. Bex1. 1Harvard Dept of Ophthalmology,
Massachusetts Eye & Ear Infirmary, Boston, MA;
2
PatientsLikeMe Research, Boston, MA *CR
1529 — B0315 Contrast acuity in Lewy
Body Disease. Helene Kergoat1, 2, G. Carcenac1,
M. Parent1. 1School of Optometry, University
of Montreal, Montreal, QC, Canada; 2Institut
universitaire de gériatrie de Montréal, Montreal,
QC, Canada
Exhibit Hall C0020-C0063
Monday, May 06, 2013 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
234 Retina and Diabetic Retinopathy
Moderators: Oliver Comyn and Stela Vujosevic
1530 — C0020 Retinal Microvascular Signs
and Incident Cardiovascular Event in Asians.
Carol Y. Cheung1, 2, W. Tay1, M. K. Ikram1, 2, P.
Mitchell4, J. Wang4, 5, C. Sabanayagam1, 3, E.
Tai6, T. Y. Wong1, 2. 1Singapore Eye Research
Institute, Singapore, Singapore; 2Department of
Ophthalmology, Yong Loo Lin School of Medicine,
National University of Singapore, Singapore,
Singapore; 3Centre for Quantitative Medicine,
Duke-NUS Graduate Medical School, Singapore,
Singapore; 4Centre for Vision Research, University
of Sydney, Sydney, NSW, Australia; 5Centre for
Eye Research Australia, University of Melbourne,
Melbourne, VIC, Australia; 6Department of
Medicine, Yong Loo Lin School of Medicine,
National University of Singapore, Singapore,
Singapore *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
129
Monday Posters
8:30 am – 10:15 am
1510 — B0237 Adaptive optics and ‘en face’
OCT imaging of the outer retina in Type 2
Macular Telangiectasia. Ferenc B. Sallo1, 2, V.
Krivosic3, K. Gocho5, M. Paques4, T. Peto6, A. C.
Bird7, A. Gaudric3. 1Research and Development,
Moorfields Eye Hospital, London, United
Kingdom; 2Visual Neuroscience, UCL Institute
of Ophthalmology, London, United Kingdom;
3
Service d’Ophtalmologie, Hopital Lariboisière
Université Paris Diderot, Paris, France; 4CHNO
des Quinze-Vingts & Institut de la Vision, Paris,
France; 5Department of Ophthalmology, Nippon
Medical University, Chiba Hokusoh Hospital,
Chiba, Japan; 6NIHR Biomedical Research
Centre for Ophthalmology, at Moorfields Eye
Hospital NHS Foundation Trust and UCL Institute
of Ophthalmology, London, United Kingdom;
7
Inherited Eye Disease, Moorfields Eye Hospital,
London, United Kingdom *CR
1531 – 1546 – Monday – Posters
1531 — C0021 Severity And Progression
Of Diabetic Retinopathy In Type 2 Macular
Telangiectasia (MacTel). Simona Degli Esposti,
T. Peto, I. Leung, F. B. Sallo, C. A. Egan. NIHR
Biomedical Research Centre for Ophthalmology at
Moorfields Eye Hospital NHS Foundation Trust and
UCL Institute of Ophthalmology, London, United
Kingdom *CR
Monday Posters
8:30 am – 10:15 am
1532 — C0022 Association between Presence
and Severity of Diabetic Retinopathy and
Coronary Artery Disease. Adam J. Plant1,
T. H. Hong1, A. Kifley1, A. Thiagalingam2, P.
Mitchell1. 1Ophthalmology, University of Sydney,
Sydney, NSW, Australia; 2Cardiology, Westmead
Millennium Institute, Sydney, NSW, Australia *CR
1533 — C0023 Novel and Traditional
Biomarkers of Diabetic Retinopathy Severity:
Multi-category Classifications Modeling. Wan
Ling Wong1, 2, J. Li4, X. LI4, 3, E. L. Lamoureux5, 3,
C. Y. Cheung3, T. Y. Wong3, 1. 1Department of
Ophthalmology, National University Health
System, Singapore, Singapore; 2Department of
Ophthalmology, Yong Loo Lin School of Medicine,
National University of Singapore, Singapore,
Singapore; 3Singapore Eye Research Institute,
Singapore National Eye Centre, Singapore,
Singapore; 4Department of Statistics and Applied
Probability, National University of Singapore,
Singapore, Singapore; 5Centre for Eye Research
Australia, Royal Victorian Eye and Ear Hospital,
University of Melbourne, Melbourne, VIC,
Australia *CR
1534 — C0024 Diabetic retinopathy mobidity
among known diabetics in urban slums of
Mumbai, India, are comparable to urban
trends anywhere in the world. Sunita Mohan1, A.
Rogiye1, M. Sonawane1, H. Gawali1, R. Srinivasan1,
S. Natarajan2, G. Kumaramanickavel1, C. A.
McCarty3. 1Ophthalmology, Aditya Jyot Foundation,
Mumbai, India; 2Aditya Jyot Eye Hospital, Mumbai,
India; 3Essentia Institute of Rural Health, Duluth,
MN
1535 — C0025 Meta-analysis examining
the systemic safety profile of intravitreal
ranibizumab injections in AMD, RVO and
DME. Robert L. Avery1, S. F. Francom2, P. Lai2, C.
Melson3, S. B. Cha4, L. Tuomi2. 1California Retina
Consultants, Santa Barbara, CA; 2Genentech, Inc.,
South San Francisco, CA; 3Experis, Cincinnati, OH;
4
Novartis Pharma, Basel, Switzerland *CR
1536 — C0026 Prevalence and risk factors
for Diabetic Retinopathy In an Urban Chinese
population: The Singapore Chinese Eye
Study. Gavin S. Tan1, 2, M. K. Ikram1, 2, Y. Zheng1,
6
, M. Chew1, C. Cheng1, 2, E. L. Lamoureux3, 1,
P. Mitchell4, J. Wang4, 3, E. Tai5, T. Y. Wong1, 2.
1
Singapore Eye Research Institute, Singapore
National Eye Centre, Singapore, Singapore;
2
Department of Ophthalmology, Yong Loo Lin
School of Medicine, National University of
Singapore, Singapore, Singapore; 3Centre for Eye
Research Australia, University of Melbourne,
Melbourne, VIC, Australia; 4Centre for Vision
Research, University of Sydney, Sydney, NSW,
Australia; 5Department of Endocrinology, Yong
Loo Lin School of Medicine, National University
of Singapore, Singapore, Singapore; 6State
Key Laboratory of Ophthalmology, Zhongshan
Ophthalmic Center, Sun Yat-sen University,
Guangzhou, China *CR
1537 — C0027 Major Risk Factors of Diabetic
Retinopathy and their Relative Importance: a
Meta-analysis Pooling Data from Individual
Subjects in 13 Studies. Jing Xie1, B. E. Klein2, J.
Shaw3, M. Yasuda4, J. M. Dekker5, T. Sharma6, K.
Mayurasakorn7, V. Mohan8, E. L. Lamoureux1, 9,
T. Y. Wong1, 9. 1Department of Ophthalmology,
Centre for Eye Research, Royal Victorian Eye and
Ear Hospital, East Melbourne, VIC, Australia;
2
Department of Ophthalmology and Visual
Sciences, University of Wisconsin School of
Medicine and Public Health, Madison, WV; 3Baker
IDI Heart and Diabetes Institute, Melbourne, VIC,
Australia; 4Department of Ophthalmology, Graduate
School of Medical Sciences, Kyushu University,
Fukuoka, Japan; 5Department of Epidemiology
and Biostatistics, the EMGO Institute for Health
and Care Research, VU University Medical
Center, Amsterdam, Netherlands; 6Shri Bhagwan
Mahavir Vitreoretinal Services, Tamil Nadu, India;
7
Department of Social Medicine, Samutsakhon
General Hospital, Samutsakhon, Thailand;
8
Department of Ophthalmology, Madras Diabetes
Research Foundation, Chennai, India; 9Singapore
Eye Research Institute, Singapore National
Eye Centre, National University of Singapore,
Singapore, Singapore *CR
1538 — C0028 Chronic Kidney Disease and
Diabetic Retinopathy in an Asian population.
Charumathi Sabanayagam1, 5, M. K. Ikram1, 4, H.
Huiqi1, P. Mitchell6, 7, J. Wang6, 7, S. Lim2, E. L.
Lamoureux8, 1, E. Tai3, 5, T. Y. Wong1, 4. 1Singapore
Eye Research Institute, Singapore, Singapore;
2
Khoo Teck Puat Hospital, Singapore, Singapore;
3
Department of Medicine, National University of
Singapore, Singapore, Singapore; 4Ophthalmology,
National University of Singapore, Singapore,
Singapore; 5Duke-NUS Graduate Medical
School, Singapore, Singapore; 6Department of
Ophthalmology, Centre for Vision Research,
University of Sydney, Australia, NSW, Australia;
7
Westmead Millennium Institute, Australia,
NSW, Australia; 8Department of Ophthalmology,
Centre for Eye Research Australia, University of
Melbourne, Australia, VIC, Australia *CR
1539 — C0029 Impact of Sociodemographic
Factors and Glycosylated Hemoglobin on the
Incidence of Diabetic Macular Edema in a Large
Nationwide Sample. Mehnaz Khan, N. Talwar, J.
D. Stein. Kellogg Eye Cnter, Ann Arbor, MI *CR
1540 — C0030 Risk Factors Associated with
Diabetic Macular Edema: A Longitudinal
Analysis of 447,407 Persons with Diabetes in a
U.S. Managed Care Network. Nidhi Talwar, M.
Khan, T. W. Gardner, J. D. Stein. Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI *CR
1541 — C0031 Twenty Years On. More or
Less Diabetic Retinopathy at Diagnosis of Type
2 Diabetes? Ahmed Sallam, I. M. Stratton, S.
Aldington, M. G. Histed, P. H. Scanlon. Diabetic
Retinopathy Research Group, Gloucestershire
Hospitals NHS Trust, Cheltenham, United Kingdom
1542 — C0032 Prevalence and Progression
of Diabetic Retinopathy in Rural China: The
Handan Eye Study. Wang Fenghua1, Y. Liang2,
J. Wang3, T. Y. Wong4, N. Wang1. 1Ophthalmology,
Beijing Tongren Eye Center, Beijing, China;
2
Ophthalmology and Visual Sciences, The Chinese
University of Hong Kong, Hong Kong, China;
3
University of Sydney, Sydney, VIC, Australia;
4
Singapore Eye Research Institute, Singapore,
Singapore *CR
1543 — C0033 Cost of a Community-Based
Diabetic Retinopathy Screening Program.
Margaret Byrne1, 3, B. L. Lam2, D. F. Parker3, M.
Ocasio1, J. Lin1, D. J. Lee1, 3. 1Epidemiology and
Public Health, University of Miami, Miami, FL;
2
Bascom Palmer Eye Institute, University of Miami,
Miami, FL; 3Sylvester Comprehensive Cancer
Center, University of Miami, Miami, FL
1544 — C0034 Factors that contribute to
vision-related quality of life scores in patients
with diabetic retinopathy. Roxanne CrosbyNwaobi1, A. Forbes1, S. Sivaprasad2. 1Florence
Nightingale School of Nursing and Midwifery,
King’s College London, London, United Kingdom;
2
Laser and Retinal Unit, King’s College Hospital,
London, United Kingdom *CR
1545 — C0035 Epidemiological study of
diabetic retinopathy in community diabetic care
program in Beijing urban area. Yanhong Zou1, Q.
Li1, N. Zhang1, W. Jia2, X. Liu2, 1. 1First Hospital of
Tsinghua University, Beijing, China; 2Sekwa Eye
Hospital, Beijing, China
1546 — C0036 Cost-utility analysis of screening
program for diabetic retinopathy in Japan:
a probabilistic Markov modeling study. Ryo
Kawasaki1, Y. Akune2, Y. Hiratsuka3, M. Yamada2.
1
Dept of Public Health/Dept of Ophthalmology,
Yamagata University, Yamagata, Japan; 2National
Institute of Sensory Organs, National Tokyo Med
Center, Tokyo, Japan; 3National Institute of Public
Health, Saitama, Japan
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
130
Monday – Posters – 1547 – 1568
1547 — C0037 A Multi-Center Study of
Diabetes Eye Screening in Community Settings
in the United States. Cynthia Owsley1, D. S.
Friedman2, J. A. Haller3, D. J. Lee4, J. Saaddine5.
1
Ophthalmology, Univ of Alabama at Birmingham,
Birmingham, AL; 2Ophthalmology, Johns Hopkins
University, Baltimore, MD; 3Ophthalmology, Wills
Eye Institute, Philadelphia, PA; 4Epidemiology
& Public Health, University of Miami, Miami,
FL; 5Division of Diabetes Translation, Centers for
Disease Control & Prevention, Atlanta, GA *CR
1549 — C0039 Long-term comparative
effectiveness of telemedicine to detect diabetic
retinopathy. Steven L. Mansberger1, 2, S. K.
Gardiner1, S. Demirel1, T. Becker2. 1Devers
Eye Institute, Portland, OR; 2Public Health and
Preventive Medicine, Oregon Health & Science
University, Portland, OR *CR, f
1550 — C0040 Teleretinal Screening in Mexico:
a Pilot Project as part of a Comprehensive
Diabetes Care Clinic in Monterrey, México.
Gilberto Zamora1, J. A. Lozano2, R. VanNess1, S.
C. Nemeth1, O. Meza2, E. Martiñón2, E. McGrew1,
P. Soliz3. 1VisionQuest Biomedical, LLC,
Albuquerque, NM; 2Clínicas del Azúcar S.A.P.I.
de C.V., Monterrey, Mexico; 3Ophthalmology and
Visual Sciences, University of Iowa, Iowa City, IA
*CR
1551 — C0041 Developing Best Practices for
Analyzing Real-World Data in Vision Care:
Comparison of Approaches for Imputing
Ethnicity from a High Volume Urban Vision
Clinic. Julia A. Haller1, 2, Y. Dai1, 2, P. P. Storey1,
L. A. Hark1, 2, L. Pizzi2, 1, B. Leiby2, 1, A. P.
Murchison1, 2. 1Ophthalmology, Wills Eye Institute,
Philadelphia, PA; 2Thomas Jefferson University,
Philadelphia, PA *CR
1552 — C0042 Non-mydriatic fundus camera
screening for diabetic retinopathy in a Northern
California safety-net setting. Brian Toy1, 2, S.
Day2, 1. 1Santa Clara Valley Medical Center, San
Jose, CA; 2Ophthalmology, Stanford University,
Palo Alto, CA
1553 — C0043 Ocular Conditions of Diabetics
and Non-Diabetics in a Primary Care Setting.
Richard VanNess1, G. Zamora1, S. C. Nemeth1, E.
McGrew1, W. C. Bauman3, S. Nguyen4, P. Soliz1, 2.
1
VisionQuest Biomedical, LLC, Albuquerque, NM;
2
Ophthalmology and Visual Sciences, University
of Iowa, Iowa City, IA; 3Retina Institute of South
Texas, San Antonio, TX; 4CommuniCare Health
Centers, San Antonio, TX *CR
1554 — C0044 A Ten-Year Retrospective
Epidemiological Study of Retinal Vein
Occlusions in a Large Urban Public Hospital.
Brendan Butler1, L. Park1, S. Reddy2, 1.
1
Ophthalmology, New York University, New York,
NY; 2Ophthalmology, DuPage Medical Group,
Downers Grove, IL
1556 — C0046 Venous Collateral Circulation
between Superior and Inferior Halves of the
Retina May Be Normal Cross-raphe Drainage.
Qingyuan Liang1, H. Liang2, D. T. Wong1, 2.
1
Ophthalmology, St Michael’s Hospital, Toronto,
ON, Canada; 2University of Toronto, Toronto, ON,
Canada *CR
1557 — C0047 Observational and Surgical
Course of Vitreomacular Traction Syndrome.
Adam Carver, R. Leonard. Dean McGee Eye
Institute, Oklahoma City, OK
1558 — C0048 The Relationship of
Retinopathy Signs and Chronic Kidney Disease
in Persons without Diabetes: the Singapore
Epidemiology of Eye Disease (SEED) Study.
Merwyn Chew1, 2, C. Sabanayagam1, W. Tay1,
S. Lim3, E. Tai4, T. Wong1, 2. 1Ophthalmology,
Singapore Eye Research Institute, Singapore,
Singapore; 2Ophthalmology, Yong Loo Lin School
of Medicine, National University of Singapore,
Singapore, Singapore; 3Diabetes Centre, Khoo Teck
Puat Hospital, Singapore, Singapore; 4Medicine,
Yong Loo Lin School of Medicine, National
University of Singapore, Singapore, Singapore *CR
1559 — C0049 German Health Services
Research Study: Estimated Prevalence and
Incidence of Pathologic Myopia and Lack of
Classification of different Stages of Pathologic
Myopia. Marc Schargus1, D. Pauleikhoff2, G.
Haeusser-Fruh4, M. M. Maier3. 1Department of
Ophthalmology, Univiversity Hospital, Wuerzburg,
Germany; 2Eye Department, St. Francis Hospital,
Muenster, Germany; 3Klinikum rechts der Isar
Department and Polyclinic of Ophthalmology,
Technical University Munich, Munich, Germany;
4
Clinical Research, Novartis Pharma, Nuermberg,
Germany *CR
1560 — C0050 Negative Electroretinograms
in the Military Personnel Complaining Night
Blindness in the Military. Mustafa Eren1, G.
Sobaci2, Y. Uysal3, U. Erdem4. 1Ophthalmology,
GATA, Ankara, Turkey; 2ophthalmology, Gata,
Ankara, Turkey; 3Ophthalmology, Gata, Ankara,
Turkey; 4Ophthalmology, Gata, Ankara, Turkey
1561 — C0051 Gestational Diabetes
Mellitus (GDM) and Changes in Retinal
Microvasculature 6 months after Delivery.
Lingjun Li1, 2, C. Y. Cheung2, M. K. Ikram2, 1, S.
Saw1, 2, T. Y. Wong2, 1. 1Saw Swee Hock School of
Public Health, National University of Singapore,
Singapore, Singapore; 2Singapore Eye Research
Institute, Singapore National Eye Centre,
Singapore, Singapore *CR
1562 — C0052 Ethnic disparity in prevalence
of retinal vein occlusions amongst older
Australians - the Melbourne Collaborative
Cohort Study. Khin Zaw Aung, G. A. Makeyeva, M.
K. Adams, E. W. Chong, P. N. Baird, R. H. Guymer,
L. D. Robman. Department of Ophthalmology,
Centre for Eye Research Australia, Royal Victorian
Eye & Ear Hospital, Melbourne, VIC, Australia
*CR
1563 — C0053 Subretinal neovascularisation
in Macular Telangiectasia type 2: Baseline
characteristics and progression over two years.
Konstantinos Balaskas1, 5, F. B. Sallo1, 2, I. Leung1,
D. Florea1, A. C. Bird3, T. Peto4. 1Department
of Research and Development, Moorfields Eye
Hospital, London, United Kingdom; 2UCL Institute
of Ophthalmology, London, United Kingdom;
3
Inherited Eye Disease, Moorfields Eye Hospital,
London, United Kingdom; 4NIHR Biomedical
Research Centre for Ophthalmology, Moorfields
Eye Hospital, London, United Kingdom; 5Medical
Retina Service, Moorfields Eye Hospital, London,
United Kingdom
1564 — C0054 Diagnostic disparities in testing
for hydroxychloroquine (HCQ)-related ocular
toxicity. Victor A. Chen, M. Ortube, S. Nusinowitz,
M. B. Gorin. Retinal Disorders and Ophthalmic
Genetics Division, Jules Stein Eye Institute, Los
Angeles, CA *CR
1565 — C0055 Prevalence and risk factors
of retinal vein occlusion in Asian Indians comparative study between Singapore and
India. Mayuri Bhargava1, 2, V. Koh1, 2, C. Y.
Cheung1, 2, W. Wong1, J. Wang3, 4, P. Mitchell4, T.
Aung1, 2, T. Y. Wong1, 2. 1Singapore Eye Research
Institute, Singapore, Singapore; 2Department of
Ophthalmology, Yong Loo Lin School of Medicine,
National University of Singapore, Singapore,
Singapore; 3Department of Epidemiology and
Public Health, Yong Loo Lin School of Medicine,
National University of Singapore, Singapore,
Singapore; 4Centre for Eye Research Australia,
University of Melbourne, Australia, Singapore,
Singapore *CR
1566 — C0056 Longitudinal Changes in
Blood Pressure and Retinal Vasculature: The
Singapore Malay Eye Study. Michelle Lim1, 2, C.
Y. Cheung1, 3, L. Li1, 3, J. Wang2, 5, M. K. Ikram1, 4,
E. L. Lamoureux1, 2, C. Cheng1, 3, T. Y. Wong1, 4.
1
Singapore Eye Research Institute, Singapore,
Singapore; 2Centre for Eye Research Australia,
Melbourne, VIC, Australia; 3Saw Swee Hock
School Public Health, National University of
Singapore, Singapore, Singapore; 4Department of
Ophthalmology, Yong Loo Lin School of Medicine,
National University of Singapore, Singapore,
Singapore; 5Centre for Vision Research, University
of Sydney, Sydney, NSW, Australia *CR
1567 — C0057 Genotype-phenotype analysis
of male subjects affected by choroideremia. Paul
Freund, M. Furgoch, I. M. MacDonald. Dept. of
Ophthalmology, University of Alberta, Edmonton,
AB, Canada
1568 — C0058 The Prevalence of Retinal
Cysts in an Aging Population: the Beaver Dam
Eye Study. Stacy M. Meuer, C. E. Myers, R. Klein,
B. E. Klein. Ophthalmology and Visual Sciences,
University of Wisconsin School of Medicine and
Public Health, Madison, WI
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
131
Monday Posters
8:30 am – 10:15 am
1548 — C0038 Effectiveness of Telemedicine
Strategies for Diabetic Retinopathy Screening:
A Systematic Review. Andrea C. Coronado1, 2, H.
Singh1, 2, J. Costella1, M. Malvankar2, 1, B. Xie1,
W. G. Hodge2, 1. 1Epidemiology & Biostatistics,
Western University, London, ON, Canada;
2
Ivey Eye Group, St. Joseph’s Hospital, Western
University, London, ON, Canada
1555 — C0045 The Angle as a Measure of
the Vein Narrowing at Retinal Arteriovenous
Crossings. Huiyuan Liang1, Q. Liang2. 1University
of Toronto, Toronto, ON, Canada; 2Ophthalmology,
St. Michael’s Hospital, Toronto, ON, Canada
Monday Posters
8:30 am – 10:15 am
1569 – 1585 – Monday – Posters
1569 — C0059 Determinants of Macular
Thickness using Spectral Domain Optical
Coherence Tomography in Healthy Eyes: the
Singapore Chinese Eye Study. Preeti Gupta1, 2,
E. Sidhartha1, 2, Y. Tham1, 2, J. Liao1, C. Cheng1, 3,
T. Y. Wong1, 5, T. Aung1, 2, C. Y. Cheung1, 4.
1
Ophthalmology, Singapore Eye Research Institute,
Singapore, Singapore; 2Ophthalmology, Yong
Loo Lin School of Medicine, National University
of Singapore, Singapore, Singapore; 3Saw Swee
Hock School of Public Health, National University
of Singapore, Singapore, Singapore; 4Centre for
Quantitative Medicine, Office of Clinical Sciences,
Duke-NUS Graduate Medical School, Singapore,
Singapore; 5Centre for Eye Research Australia,
University of Melbourne, Royal Victorian Eye and
Ear Hospital, Melbourne, VIC, Australia *CR
1570 — C0060 Risk of Central Serous
Chorioretinopathy in Adults Prescribed Oral
Corticosteroids. Der-Chong Tsai1, 2, S. Chen3, P.
Chou1, H. Leu4. 1Institute of Public Health, National
Yang-Ming University, Taipei, Taiwan; 2Department
of Ophthalmology, National Yang-Ming University
Hospital, Yilan, Taiwan; 3Department of
Ophthalmology, Taipei Veterans General Hospital,
Taipei, Taiwan; 4Healthcare and Management
Center, Taipei Veterans General Hospital, Taipei,
Taiwan
1571 — C0061 Ocular Findings In Aplastic
Anemia: Multicenter Study and Literature
review. Ramzi Alameddine1, A. M. Mansour1, 2,
J. Lee4, S. Yahng3, K. Kim4, M. Shahin5, N.
Hamerschlak6, R. Belfort Neto7, S. K. Kurup8.
1
Ophthalmology, American University of Beirut,
Beirut, Lebanon; 2Ophthalmology, Rafic Hariri
University Hospital, Beirut, Lebanon; 3Division
of Hematology- Catholic Blood and Marrow
Transplantation Center, Seoul St Mary’s Hospital,
The Catholic University of Korea, Seoul, Republic
of Korea; 4Ophthalmology, Seoul St Mary’s
Hospital, The Catholic University of Korea, Seoul,
Republic of Korea; 5Ophthalmology, Mansoura
University, Mansoura City, Egypt; 6Oncology &
Hematology Program, Instituto Israelita de Ensino e
Pesquisa Albert Einstein, São Paulo, Brazil; 7Vision
Institute, Hospital São Paulo, Federal University
of São Paulo, São Paulo, Brazil; 8Ophthalmology,
Wake Forest University Baptist Medical Center,
Winston-Salem, NC *CR
1572 — C0062 Frequency and risk factors of
retinal hemorrhages in adult Chinese in rural
and urban China. Liang Xu1, Y. Wang1, J. Zhou1,
J. B. Jonas2, 1. 1Beijing Institute of Ophthalmology,
Beijing Tongren Hospital, Beijing, China;
2
Ophthalmology, Medical Faculty Mannheim,
Manheim, Germany *CR
1573 — C0063 Retinal Microvascular Caliber
and Coronary Artery Stenoses. Bamini Gopinath1,
A. J. Plant1, A. Thiagalingam2, G. Burlutsky1, T. Y.
Wong3, 4, P. Mitchell1. 1Centre for Vision Research,
University of Sydney, Sydney, NSW, Australia;
2
Centre for Heart Research, University of Sydney,
Sydney, NSW, Australia; 3Centre for Eye Research
Australia, University of Melbourne, Sydney, VIC,
Australia; 4Singapore Eye Research Institute,
National University of Singapore, Singapore,
Singapore *CR
Exhibit Hall D0001-D0022
Monday, May 06, 2013 8:30 AM-10:15 AM
Biochemistry/Molecular Biology
235 Ocular Disease Expression,
Proteomics, Biomarkers, and
Polymorphisms
Moderator: Roger W. Beuerman
1574 — D0001 New Potential Biomarker
of Neurofibromatosis Type I, discovered with
Multi-Spectral Imaging (MSI) of the Retinal
Pigment Epithelium (RPE) and Choroid. Dorothy
Hitchmoth4, 1, J. Sherman2, 3. 1Surgery, Department
of Veterans Affairs, White River Junction, VT;
2
Clinical Science, SUNY College of Optometry,
New York, NY; 3SUNY Eye Institute, State
University of New York, New York, NY; 4Affiliate
Residency Programs, New England College of
Optometry, Boston, MA *CR
1575 — D0002 Quantitative Proteomic
Analysis of TIMP3 Dysfunction. Geeng-Fu Jang1,
A. Cutler1, L. Zhang1, J. S. Crabb1, H. Stoehr2, J.
W. Crabb1, B. Anand-Apte1. 1Cole Eye Institute
& Lerner Research Institute, Cleveland Clinic,
Cleveland, OH; 2Institute of Human Genetics,
University of Regensburg, Regensburg, Germany
*CR
1576 — D0003 Association of the
polymorphism of the 5’ UTR region of the HBD1
gene in patients with infectious blepharitis.
Hector J. Perez-Cano1, I. V. Gonzalez Leon2, O.
Fernandez-Vizcaya2, J. Nolasco-Lopez1, J. R.
Clemenceau1, A. Robles-Contreras1. 1Biomedical
Research Center, Hospital Foundation “Nuestra
Senora de la Luz”, Mexico, Mexico; 2cornea,
hospital foundation “Nuestra Señora de la Luz”,
Mexico, Mexico
1577 — D0004 Comparative Analysis of
Donor Medical History and Disease Attributes.
Kieron Torres, V. F. Oliver, R. Enke, J. Song, S. L.
Merbs. Ophthalmology, Johns Hopkins Wilmer Eye
Institute, Baltimore, MD
1578 — D0005 Treatment of Usher syndrome
with antisense oligonucleotides. Jennifer J. Lentz1,
M. Flaat1, F. M. Jodelka2, A. Hinrich2, Y. Zhou1, K.
McCaffery2, D. M. Duelli3, N. G. Bazan1, F. Rigo4,
M. L. Hastings2. 1Neuroscience Center, LSUHSC,
New Orleans, LA; 2Cell Biology and Anatomy,
Rosalind Franklin University, North Chicago, IL;
3
Cellular and Molecular Pharmacology, Rosalind
Franklin University, North Chicago, IL; 4Isis
Pharmaceuticals, Carlsbad, CA *CR
1579 — D0006 Genetic Heterogeneity Among
Patients with Pericentral Retinitis Pigmentosa.
Jason Comander1, 2, A. Langsdorf1, S. Harper2, C.
Weigel-DiFranco2, M. B. Consugar1, M. Sandberg2,
X. Gai3, J. A. White1, E. L. Berson2, E. A. Pierce1, 2.
1
Ocular Genomics Institute, Massachusetts Eye and
Ear Infirmary, Harvard Medical School, Boston,
MA; 2Berman-Gund Laboratory for the Study of
Retinal Degenerations, Massachusetts Eye and Ear
Infirmary, Harvard Medical School, Boston, MA;
3
Center for Biomedical Informatics, Department of
Molecular Pharmacology and Therapeutics, Loyola
University Chicago Health Sciences Division,
Maywood, IL *CR
1580 — D0007 Distinct molecular mechanisms
responsible for different retinopathies caused
by CRX mutations DNH and LFH. Alan Zhang,
N. M. Tran, X. Zhang, S. Chen. Ophthalmology,
Washington University St. Louis, st louis, MO *CR
1581 — D0008 Comprehensive genetic
analysis of an Usher I patient cohort. Kinga
M. Bujakowska1, E. Place1, M. B. Consugar1, D.
G. Taub1, A. Langsdorf1, C. Weigel-DiFranco2, S.
Harper2, X. Gai3, E. L. Berson1, 2, E. A. Pierce1, 2.
1
Ocular Genomics Institute, Massachusetts Eye and
Ear Infirmary, Harvard Medical School, Boston,
MA; 2Berman-Gund Laboratory for the Study of
Retinal Degenerations, Harvard Medical School,
Massachusetts Eye and Ear Infirmary, Boston,
MA; 3Department of Molecular Pharmacology and
Therapeutics, Loyola University Chicago Health
Sciences Division, Maywood, IL *CR
1582 — D0009 Epigenetic factors in the
pathogenesis of corneal dystrophy. Xiaohua Li,
X. Li, M. Yuan, R. Yin. Henan Eye Institute, Henan
Provincial Eye Hospital, Zhengzhou, China
1583 — D0010 Biomarkers for Neuronal
Injury following Blast Trauma to the Eye. Steven
G. Hart1, X. Wang1, T. S. Rex2, E. E. Geisert1.
1
Ophthalmology, University of Tennessee Health
Science Center, Memphis, TN; 2Ophthalmology,
Vanderbilt University, Nashville, TN *CR
1584 — D0011 Colorimetric Image Analysis in
Detection of Leukocoria from Retinoblastoma
in Snapshots Taken by Standard Digital
Photography. Katherine E. Talcott1, E. Shaw4, R.
Holden4, B. W. Taylor4, E. J. Baker3, G. Hamerly3,
A. Kentsis2, S. Mukai1, C. Rodriguez-Galindo2, B. F.
Shaw4. 1Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA; 2Pediatric Oncology, Dana
Farber Cancer Institute, Boston, MA; 3Computer
Science, Baylor University, Waco, TX; 4Chemistry
and Biochemistry, Baylor University, Waco, TX
1585 — D0012 Initial proteomic analysis of
structural changes in the aging human vitreous.
Qianru Zhang3, 1, Y. Shui1, A. Kettler2, J. P. Malone2,
R. R. Townsend2, D. C. Beebe1. 1Dept of Ophthal &
Vis Sci, Washington Univ Sch of Med, Saint Louis,
MO; 2Proteomics Core Lab, Washington Univ
Sch of Med, Saint Louis, MO; 3Ophthalmology,
Zhejiang University, Hangzhou, China *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
132
Monday – Posters – 1586 – 1608
1586 — D0013 Manipulation of the MicroRNA
Content of Endothelial Progenitor Cell-derived
Extracellular Vesicles. David A. Simpson, E.
Brown, C. L. O’Neill, R. J. Medina, J. GuduricFuchs. Centre for Vision & Vascular Science,
Queens University Belfast, Belfast, United
Kingdom
1587 — D0014 P2X7 Expression in Vitrectomy
Samples. Cheryl Chi1, D. Husain1, C. B.
Rich2, N. H. Siegel1, V. E. Trinkaus-Randall1, 2.
1
Ophthalmology, Boston University School of
Medicine, Boston, MA; 2Biochemistry, Boston
University School of Medicine, boston, MA
1589 — D0016 Probing the sensitivity of
rhodopsin expression to chromophore levels
in the retina. Lauren L. Daniele1, E. N. Pugh2, 1.
1
Cell Biology & Human Anatomy, University
of California Davis, Davis, CA; 2Physiology &
Molecular Biology, Univ of California Davis,
Davis, CA
1590 — D0017 Vitreoretinal interface
abnormalities and viscoelastic behavior of the
vitreous. Sanket U. Shah1, D. C. Reed1, S. Abbassi1,
R. Freeman2, P. Sharif-Kashani2, P. Kavehpour2,
J. Hubschman1. 1Department of Ophthalmology Retina Division, Jules Stein Eye Institute and David
Geffen School of Medicine, UCLA, Los Angeles,
CA; 2Mechanical and Aerospace Engineering,
UCLA, Los Angeles, CA
1591 — D0018 Gene expression profiling of the
human macula. Kristis Vevis1, M. B. Powner1, J.
Mckenzie1, M. Zhu2, M. C. Gillies2, M. Fruttiger1.
1
UCL Institute of Ophthalmology, London, United
Kingdom; 2University of Sydney, Save Sight
Institute, Sydney, ACT, Australia *CR
1592 — D0019 Identification of piRNAs in the
Retina. Yingfeng Zheng1, 2, Q. Wang1, X. Lin1, M.
He1. 1Zhongshan Ophthalmic Center, Guangzhou,
China; 2Singapore Eye Research Institute,
Singapore, Singapore
1593 — D0020 Unpredictable Consequences
of Systemic Valproic Acid Treatment on the
Rate of Photoreceptor Loss in Different Pde6b
Rd-mutations. Kenneth P. Mitton1, 2, D. W. Byrd1,
E. Guzman1, 2, A. Wallace1, 2, T. Tran1, J. Sotzen1.
1
Control of Gene Expression Lab, Eye Research
Institute of Oakland University, Rochester, MI;
2
Pediatric Retinal Research Laboratory, Eye
Research Institute of Oakland University, Rochester,
MI
1594 — D0021 MicroRNA-21 (miR-21) Induces
Down-regulation Of PEDF In Retinal Pigmented
Epithelial Cells By Suppression Of PPAR Alpha.
Manuela Bartoli1, C. Stampley2, S. Shaw1, P. M.
Martin3, F. Lamoke1. 1Ophthalmology, Georgia
Health Sciences University, Augusta, GA; 2Rollins
School of Public Health, Emory University, Atlanta,
GA; 3Department of Biochemistry and Molecular
Biology, Georgia Health Sciences University,
Augusta, GA
Exhibit Hall D0023-D0037
Monday, May 06, 2013 8:30 AM-10:15 AM
Biochemistry/Molecular Biology
236 Glaucoma Biochemistry
and Mechanisms
Moderator: John H. Fingert
1596 — D0023 Association of LOXL1 Gene
Polymorphisim in Turkish Population with
Pseudoexfoliation Syndrome and Glaucoma.
Nilgun Yildirim, Y. Yaz, O. Cilingir, F. Sahin, Z.
Yüksel. Department of Ophthalmology, Eskisehir
Osmangazi Univ Med Sch, Eskisehir, Turkey
1597 — D0024 Elevated TGFβ1 concentration
in the plasma of glaucoma patients. John Kuchtey,
L. Burgess, M. B. Parks, J. Kunkel, M. A. Brantley,
R. W. Kuchtey. Vanderbilt Eye Institute, Vanderbilt
University, Nashville, TN
1598 — D0025 Association of the T allele of
rs41435250 of LOXL1 with elevated risk of
exfoliation syndrome and exfoliation glaucoma in
a Mexican population. Dalia C. Guadarrama1, J.
C. Zenteno1, 2, A. Miranda3, C. Elizondo1. 1Genetics,
Institute Of Ophthalmology Conde de Valenciana,
Mexico, Mexico; 2Biochemistry Facultad de
Medicina, National Autonomous University of
Mexico (Unam), Mexico, Mexico; 3Genetics,
National Rehabilitation Institute, Mexico, Mexico
1599 — D0026 Regulation of rhodopsin gene
expression by DNA methylation. Jin Song, T.
Masuda, D. J. Zack, S. L. Merbs. Department
of Ophthalmology, Johns Hopkins University,
Baltimore, MD *CR
1600 — D0027 MicroRNA 184 regulates
Ezrin expression and potentially impacts
Ezrin-dependent functions in human Retinal
Pigment Epithelium. Nishantha Gunawardena,
N. Golestaneh, M. Kokkinaki, M. Gunawan.
Georgetown University, Washington, DC
1601 — D0028 The role of Rgcs1 gene Spink2
in Autophagy and ganglion cell susceptibility to
optic nerve damage. Margaret Maes1, 2, J. Dietz1,
C. Schlamp1, R. W. Nickells1. 1Ophthalmology and
Visual Sciences, University of Wisconsin-Madison,
Madison, WI; 2Cellular and Molecular Pathology
Graduate Program, University of WisconsinMadison, Madison, WI
1602 — D0029 mTor is Involved in the
Dexamethasone Induced Expression of β3
Integrin in Human Trabecular Meshwork Cells.
Jennifer A. Faralli1, D. Gagen1, D. M. Peters1, 2.
1
Pathology and Laboratory Medicine, University
of Wisconsin, Madison, WI; 2Ophthalmology and
Visual Sciences, University of Wisconsin, Madison,
WI
1603 — D0030 An analysis of normal and
glaucomatous human lamina cribrosa and
trabecular meshwork cell behaviours as
determined by the surrounding extracellular
matrix. Sara McNally1, D. M. Wallace1, 2, C. J.
O’Brien1, 2. 1Dept of Ophthalmology, Catherine
McAuley UCD Clinical Research Centre, Dublin,
Ireland; 2School of Medicine and Medical Science,
University College Dublin, Belfield, Dublin, Ireland
1604 — D0031 Mitochondrial membrane
potential, as a measure of mitochondrial
function, in patients with normal tension
glaucoma vs ocular hypertension. Gerassimos
Lascaratos1, D. Chau2, H. Zhu3, A. Schapira2, D.
F. Garway-Heath1. 1Moorfields Eye Hospital and
UCL Institute of Ophthalmology, London, United
Kingdom; 2Clinical Neurosciences, UCL Institute
of Neurology, Royal Free Hospital, London, United
Kingdom; 3Department of Optometry and Visual
Science, City University, London, United Kingdom
*CR
1605 — D0032 Changes in antibodies from
glaucoma patients lead to changes in apoptosis
pathways of neuroretinal cells. Katharina Bell,
C. Wilding, S. Funke, N. Pfeiffer, F. H. Grus.
Experimental Ophthalmology, Medical Center
Univesity of Mainz, Mainz, Germany *CR
1606 — D0033 Human Ocular Distribution
Of Products of the Poag-Associated CDKN2BAS1 Gene Cluster Region. John P. Wood1, G.
Chidlow1, R. J. Casson1, S. Sharma2, K. P. Burdon2,
J. E. Craig2. 1Ophthalmic Research Laboratories,
S Australian Institute of Ophthalmology, Adelaide,
SA, Australia; 2Department of Ophthalmology,
Flinders University, Bedford Park, SA, Australia
1607 — D0034 Analysis of the covalent high
molecular weight protein complex containing
optineurin and its relationship with glaucoma.
Jie Gao1, 2, M. Ohtsubo1, Y. Hotta2, S. Minoshima1.
1
Department of Photomedical Genomics, Basic
Medical Photonics Laboratory, Medical Photonics
Research Center, Hamamatsu University School
of Medicine, Hamamatsu, Japan; 2Department of
Ophthalmology, Hamamatsu University School of
Medicine, Hamamatsu, Japan
1608 — D0035 Post-transcriptional regulation
of γ-synuclein expression and its role in
glaucomatous alterations. Andrei Surguchov1, 2, I.
G. Surgucheva1, 2. 1Research, Retinal Biology Lab,
VAMCKC, Kansas City, MO; 2Neurology, Kansas
University, Kansas City, KS
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
133
Monday Posters
8:30 am – 10:15 am
1588 — D0015 Pro-inflammatory cytokines
induce apoptosis of human retinal endothelial
cells by downregulating Hsp27. Ram H. Nagaraj,
A. Palmer, R. B. Nahomi. Ophthalmology and
Visual Sciences, Case Western Reserve University,
Cleveland, OH
1595 — D0022 Suppression of microglial
inflammatory response by sigma receptor 1
ligand (+)-Pentazocine. Jing Zhao1, 3, S. B. Smith2, 3,
K. Bollinger1, 3. 1Ophthalmology, Georgia Health
Sciences University, Augusta, GA; 2Cell Biology
and Anatomy, Georgia Health Sciences University,
Augusta, GA; 3Vision Discovery Institute, Georgia
Health Sciences University, Augusta, GA
Monday Posters
8:30 am – 10:15 am
1609 – 1629 – Monday – Posters
1609 — D0036 Soluble guanylate cyclase:
an emerging therapeutic target in open angle
glaucoma. Emmanuel S. Buys1, Y. Ko2, C. Alt3,
H. Gong4, P. Brouckaert5, J. L. Wiggs6, M. S.
Gregory-Ksander2, 6, L. R. Pasquale6, 7, K. D.
Bloch1, 8, B. R. Ksander2, 6. 1Anesthesia, Critical
Care, and Pain Medicine, Massachusetts General
Hospital, Boston, MA; 2Ophthalmology, Schepens
Eye Research Institute, Boston, MA; 3Wellman
Center for Photomedicine and Center for Systems
Biology, Massachusetts General Hospital, Boston,
MA; 4Ophthalmology, Boston University School
of Medicine, Boston, MA; 5VIB Department of
Molecular Biomedical Research, Ghent University,
Ghent, Belgium; 6Ophthalmology, Massachusetts
Eye and Ear Infirmary, Boston, MA; 7Channing
Division of Network Medicine, Brigham and
Women’s Hospital, Boston, MA; 8Cardiology
Division, Department of Medicine, Massachusetts
General Hospital, Boston, MA
1610 — D0037 Mammalian Expression and
Biophysical Examination of Human Wild-Type
Optineurin Protein. Hongyu Ying, X. Shen, M.
Wang, B. Yue. Ophthal & Visual Sciences, Univ of
Illinois at Chicago, Chicago, IL
Exhibit Hall D0246-D0280
Monday, May 06, 2013 8:30 AM-10:15 AM
Cornea
237 Corneal Cross-linking
and Biomechanics
Moderator: Arthur Hammer
1611 — D0246 The efficacy of corneal crosslinking shows a sudden decrease with very high
intensity UV-light and short treatment time.
Jeremy Wernli1, 3, S. Schumacher1, 3, E. Spoerl2,
M. C. Mrochen1, 3. 1IROC Science to Innovation
AG, Zurich, Switzerland; 2Ophthalmology, Carl
Gustav Carus University Hospital Dresden,
Dresden, Germany; 3IROC Innocross AG, Zurich,
Switzerland *CR
1612 — D0247 Corneal Biomechanical
Properties after UV Cross-linking in the
Rabbit. Michael D. Twa1, J. Li2, R. Manapuram2,
F. M. Menodiado2, S. Aglyamov3, S. Emelianov3,
K. Larin2. 1College of Optometry, University of
Houston, Houston, TX; 2Biomedical Engineering,
University of Houston, Houston, TX; 3Biomedical
Engineering, University of Texas, Austin, TX *CR
1613 — D0248 The Rigidity of Corneas before
and after Corneal Cross-linking - as measured by
Corvis® ST. Sashia Bak-Nielsen, I. Bach Pedersen,
A. Ivarsen, J. Hjortdal. Ophthalmology, Aarhus
University Hospital, Aarhus, Denmark *CR
1614 — D0249 Association of Ambient Solar
Radiation with Biomechanical Properties of the
Cornea In an elderly population: The Alienor
Study. Cedric Schweitzer1, C. Delcourt2, F. Malet1,
M. Le Goff2, J. Korobelnik1, 2, M. B. Rougier1, M.
Delyfer1, 2, J. Dartigues2, P. Barberger-gateau2,
J. Colin1. 1Ophthalmology, University Hospital
Pellegrin, Bordeaux, France; 2INSERM, ISPED,
Bordeaux university, bordeaux, France *CR
1615 — D0250 Effect of UVA-Rb cross-linking
on through-thickness strains in canine corneas.
Joel Palko1, X. Pan2, J. Liu3, 4. 1Wexner Medical
Center, Ohio State University, Columbus, OH;
2
Center for Biostatistics, Ohio State University,
Columbus, OH; 3Deprtment of Biomedical
Engineering, Ohio State University, Columbus,
OH; 4Department of Ophthalmology, Ohio State
University, Columbus, OH
1616 — D0251 In Vivo Evaluation of Corneal
Biomechanical Properties After Corneal
Collagen Cross-linking Therapy. Raksha Urs1,
H. Lloyd1, R. H. Silverman1, 2. 1Ophthalmology,
Columbia University Medical Center, New York,
NY; 2Frederic L. Lizzi Center for Biomedical
Engineering, Riverside Research Institute, New
York, NY
1617 — D0252 Long Term Follow-Up of
Corneal Topographic Indices Following Collagen
Crosslinking In Eyes with Keratoconus. Erick
Hernández-Bogantes, L. Wu, D. Flikier. Instituto de
Cirugía Ocular, San José, Costa Rica *CR
1618 — D0253 Comparison of corneal
changes between standard and transepithelial
riboflavin-UVA crosslinking method using
multiphoton microscopy and second harmonic
imaging. Praveena Gupta1, B. Anyama2, K. M.
Wells2, M. Motamedi3, 1, B. F. Godley1, G. Vargas3.
1
Ophthalmology & Visual Sciences, Univ of
Texas Medical Branch, Galveston, TX; 2School
of Medicine, University of Texas medical Branch,
Galveston, TX; 3Center for Biomedical Engineering,
Univ of Texas Medical Branch, Galveston, TX
1619 — D0254 Biaxial Biomechanical Study
of UVA-RF Corneal Cross-linking. William A.
Eddington, M. D. Friedman, E. A. Sherr, D. Muller.
Avedro, Waltham, MA *CR
1620 — D0255 Finite Element Analysis of
Treatment of Corneal Astigmatism with Collagen
Crosslinking. Ibrahim Seven1, 2, A. Sinha Roy1, W.
J. Dupps1, 2. 1Ophthalmology, Cleveland Clinic Cole
Eye Inst, Cleveland, OH; 2Biomedical Engineering,
Cleveland Clinic Lerner Research Institute,
Cleveland, OH *CR
1621 — D0256 Corneal geometric stress factor
to evaluate response to corneal collagen crosslinking in keratoconus. Riccardo Vinciguerra1, 2,
C. J. Roberts3, A. M. Mahmoud3, C. Azzolini2, P.
Vinciguerra1. 1Opthalmology, Humanitas Clinical
and Research Center, Milan, Italy; 2Dept. of
Surgical and Morphological Sciences, University
of Insubria, Circolo Hospital, Varese, Italy;
3
Ophthalmology and Biomedical Engineering, The
Ohio State University, Columbus, OH *CR
1622 — D0257 Evaluation of the riboflavin and
Ultraviolet light effect on keratocytes cultivated
in vitro. Joyce L. Covre, P. C. Cristovam, R. R.
Loureiro, R. M. Hazarbassanov, M. S. Campos, H.
Sato, J. A. Gomes. Ophthalmology, UNIFESP, Sao
Paulo, Brazil *CR
1623 — D0258 Long term evaluation of corneal
permeability following cross-linking in a live
animal model. Jay M. Stewart, R. Lamy, E. Chan.
Ophthalmology, Univ of California-San Francisco,
San Francisco, CA
1624 — D0259 Modulation of matrix stiffness
throughout corneal wound healing following
phototherapeutic keratectomy. Sara M. Thomasy1,
V. K. Raghuanthan1, P. C. Strom1, J. C. Sermeno1, P.
Russell1, C. J. Murphy1, 2. 1Surgical and Radiological
Sciences, School of Veterinary Medicine, University
of California, Davis, Davis, CA; 2Ophthalmology &
Vision Science, School of Medicine, University of
California, Davis, Davis, CA *CR
1625 — D0260 Comparison of Biomechanical
and Tomographic Data in Subclinical
Keratoconus. Paolo Vinciguerra1, R. Ambrosio3, M.
R. Romano1, I. C. Ramos3, C. Azzolini2, S. Trazza1,
R. Vinciguerra1, 2. 1Ophthalmology, Istituto Clinico
Humanitas, Milan, Italy; 2Dept. of Surgical and
Morphological Sciences, University of Insubria,
Circolo Hospital, Varese, Italy; 3Instituto de Olhos
Renato Ambrósio, Rio De Janeiro, Brazil *CR
1626 — D0261 Correlation of Biomechanic
Parameters Measured by Corvis ST (Oculus®)
and by Ocular Response Analyzer (ORA,
Reichert®). Michael Haustein, E. Spoerl, L. E.
Pillunat. Dept Ophthalmology, University of
Dresden, Dresden, Germany
1627 — D0262 The correlation between ocular
response analyzer keratoconus match index
and subjective topographic assessment using
the Orbscan to screen for keratoconus. Ryan A.
Vasan, R. M. St Clair, S. A. Hussnain, A. G. Alzaga
Fernandez, C. E. Starr. Ophthalmology, Weill
Cornell Medical College, New York, NY
1628 — D0263 Investigation of corneal
vibration during air puff deformation using
numerical approaches with clinical validation.
Zhaolong Han1, C. J. Roberts2. 1Department of
Civil Engineering, School of Naval Architecture,
Ocean and Civil Engineering, Shanghai Jiao Tong
University, Shanghai, China; 2Department of
Ophthalmology and Department of Biomedical
Engineering,The Ohio State University, Columbus,
OH *CR
1629 — D0264 Modeling corneal response to
an air puff using deformation data to derive
Young’s modulus. Kimberly M. Metzler1, C. J.
Roberts1, 2, S. M. Whitaker3, M. J. Lawrence3, J. E.
Malik1, J. P. Bons3. 1Biomedical Engineering, Ohio
State University, Columbus, OH; 2Opthalmology,
Ohio State University, Columbus, OH; 3Mechanical
and Aerospace Engineering, Ohio State University,
Columbus, OH *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
134
Monday – Posters – 1630 – 1652
1630 — D0265 OCT-Vibrography: A Novel
Non-Contact Method to Estimate Corneal
Biomechanical Properties. Sabine Kling1, E.
Chang2, G. Scarcelli2, N. Bekesi1, S. H. Yun2, S.
Marcos1. 1Instituto de Optica, Consejo Superior de
Invest Cientificas, Madrid, Spain; 2Wellman Center,
Massachusetts General Hospital, Boston, MA *CR
1632 — D0267 Effect of Different Hydration
Media on Ex Vivo Corneal Elasticity
Measurements. Janice Dias, N. M. Ziebarth.
Biomedical Engineering, University of Miami,
Coral Gables, FL
1633 — D0268 Comparison of Biomechanical
Effects of Small Incision Lenticule Extraction
(SMILE) and Laser in situ Keratomileusis
(LASIK): A Finite Element Analysis Study.
Abhijit Sinha Roy1, W. J. Dupps1, 3, C. J. Roberts2.
1
Ophthalmology, Cleveland Clinic Cole Eye
Institute, Cleveland, OH; 2Department of
Ophthalmology and Department of Biomedical
Engineering, The Ohio State University, Columbus,
OH; 3Department of Biomedical Engineering,
Cleveland Clinic Lerner Research Institute,
Cleveland, OH *CR
1634 — D0269 Biomechanical properties of
the cornea and graft after Descemet’s stripping
endothelial keratoplasty. Saima Qureshi1,
N. H. Brown1, N. Shaikh2, 1. 1Ophthalmology,
Howard University Hospital, Washington, DC;
2
Ophthalmology, Veterans Affairs Medical Center,
Orlando, FL
1635 — D0270 Influence of Pregnancy on the
Corneal Biomechanical Properties. Roo Min Jun,
G. Cho, K. Choi. Dept of Ophthalmology, School
of Medicine, Ewha Womans University, Seoul,
Republic of Korea
1636 — D0271 Elastic modulus of keratocytes
and myofibroblasts differ regardless of
substratum stiffness. Vijay K. Raghuanthan1, P. C.
Strom1, S. M. Thomasy1, P. Russell1, C. J. Murphy1, 2.
1
Dept of Surgical and Radiological Sciences,
University of California Davis, Davis, CA; 2Dept of
Ophthalmology and Vision Science, University of
California Davis, Davis, CA *CR
1637 — D0272 Corneal biomechanical
properties among healthy Chinese, Indian and
Caucasian: A pilot study. Yin Zhi Wong, A. K. Lam.
School of Optometry, The Hong Kong Polytechnic
University, Hong Kong SAR, Hong Kong
1639 — D0274 The relationship between
anterior segment biometry and corneal
biomechanics in myopia. Hetal Buckhurst1, B.
Gilmartin2, R. Cubbidge2, M. Nagra2, N. S. Logan2.
1
School of Health Professions, Plymouth University,
Plymouth, United Kingdom; 2School of Life and
Health Sciences, Aston University, Birmingham,
United Kingdom
1640 — D0275 Comparison of biomechanical
properties of cornea in diabetic and nondiabetic
primary open angle glaucoma patients. Faruk
Ozturk1, S. Akkaya2, E. Can3. 1Ulucanlar Eye
Hospital, Ankara, Turkey; 2Yildirim Beyazit
Hospital, Ankara, Turkey; 3Ondokuz Mayis
University, Samsun, Turkey
1641 — D0276 Collagen Macrostructure and
Corneal Shape: Lessons from Different Species.
Moritz Winkler1, Y. Xie2, T. Yuen1, G. Shoa1, R.
Hueter3, K. K. Svoboda4, C. J. Murphy5, D. J.
Brown2, J. V. Jester2, 1. 1Biomedical Engineering,
University of California, Irvine, Irvine, CA; 2Gavin
Herbert Eye Institute, University of California,
Irvine, Irvine, CA; 3Mote Marine Laboratory,
Sarasota, FL; 4Biomedical Sciences, Texas A&M
Health Science Center, Dallas, TX; 5Department of
Surgical and Radiological Sciences, University of
California, Davis, Davis, CA *CR
1642 — D0277 Inter- and Intra-Lamellar
Slippage of Collagen Fibrils as a Potential
Mechanism of Keratoconus Progression. Michael
Koster1, C. Boote2, K. M. Meek2, P. G. Fowler3, C.
A. Girkin3, G. Meschke1, R. Grytz3. 1Institue for
Structural Mechanics, Ruhr University Bochum,
Bochum, Germany; 2School of Optometry and
Vision Sciences, Cardiff University, Cardiff, United
Kingdom; 3Ophthalmology, University of Alabama
at Birmingham, Birmingham, AL *CR
1643 — D0278 Clear Corneal Incision:
Sealability of the Manual Versus LensAR laser
generated Full Thickness Incision. E. Valas
Teuma1, L. Dumanoir1, A. Barry1, G. Gray1, G.
Magruder2, S. Bott1. 1R&D, LensAR Inc, Orlando,
FL; 2LaserVue, Orlando, FL *CR
1644 — D0279 Effect of Intraocular Pressure
on Speed-of-Sound and Thickness in Ex
Vivo Cornea in Intact Globes. Harriet Lloyd1,
M. Berganovsky1, R. H. Silverman1, 2, R. Urs1.
1
Ophthalmology, Columbia University Medical
Center, New York, NY; 2Frederic L. Lizzi Center for
Biomedical Engineering, Riverside Research, New
York, NY
1645 — D0280 Change of corneal curvature
under the open eye condition and the slightly
closed eye condition. Yuko Shibata1, H. Uozato1, 2,
M. Hirota1, T. Kawamorita1, 2. 1Ophthalmology &
Visual Sciences, Kitasato Univ Graduate School,
Sagamihara, Japan; 2Orthoptics and Visual Sciences,
Kitasato University, Sagamihara, Japan
Exhibit Hall D0281-D0333
Monday, May 06, 2013 8:30 AM-10:15 AM
Cornea / Visual Neuroscience
238 Corneal Endothelium
Moderators: Francois Majo and Sanjay V. Patel
1646 — D0281 Cyclosporin A inhibits cell
death of Corneal Endothelial Cells by protecting
michondrial membrane potential. Toshinari
Funaki, K. Ohtomo, M. Yamaguchi, A. Matsuda, A.
Murakami. Ophthalmology, Juntendo Univ School
of Medicine, Bunkyo-ku, Japan *CR
1647 — D0282 Success Isolation of Human
Corneal Endothelial Cells for Clinical Use. Jin
San Choi1, 3, M. Giegengack1, 2, E. Kim4, M. Kim4,
R. D’Agostino5, G. Khang4, S. Soker1. 1Wake Forest
Institute for Regenerative Medicine, Wake Forest
University Health Sciences, Winston-Salem, NC;
2
Department of Ophthalmology, Wake Forest
School of Medicine, Winston-Salem, NC; 3Oular
Systems, INC, Winston-Salem, NC; 4BIN Fusion
Technology, Chonbuk National University, Jeonju,
Republic of Korea; 5Public Health SciencesDepartment of Biostatistics, Wake Forest School of
Medicine, Winston-Salem, NC *CR
1648 — D0283 A cell therapy approach
to address corneal endothelial dysfunction.
Karen Alvarez-Delfin1, N. J. Kunzevitzky1, 2, A. D.
Weisman1, R. M. Merkhofer1, J. L. Goldberg1, 3.
1
Bascom Palmer Eye Institute, Interdisciplinary
Stem Cell Institute, University of Miami, Miami,
FL; 2Emmetrope Ophthalmics, Coral Gables, FL;
3
Shiley Eye Center, University of California San
Diego, San Diego, CA
1649 — D0284 Comparison of early corneal
peripherial endothelial cell loss following
femtosecond laser - assisted cataract surgery
and conventional phacoemulsification. Gábor
L. Sándor, I. Takács, K. Kranitz, E. Juhasz, I.
Kovacs, Z. Z. Nagy. Department of Ophthalmology,
Semmelweis University, Budapest, Hungary *CR
1650 — D0285 Effect of glaucoma tube-shunt
position on corneal thickness and endothelial
cell density. Euna Koo1, J. Hou1, Y. Han1, J.
D. Keenan1, 2, R. L. Stamper1, B. H. Jeng1, 2.
1
Ophthalmology, University of California San
Francisco, San Francisco, CA; 2Proctor Foundation,
University of California San Francisco, San
Francisco, CA *CR
1651 — D0286 Human Cytomegalovirusmediated inflammatory responses of corneal
endothelial cells. Michiko Kandori1, D. Miyazaki1,
K. Yakura1, Y. Noguchi1, Y. Yamamoto1, Y. Inoue1,
T. Suzutani2. 1Ophthalmology, Tottori University,
Yonago, Japan; 2Microbiology, Fukushima Medical
University, Fukushima, Japan
1652 — D0287 Engineering of Human Corneal
Endothelial Grafts. Yingting Zhu, B. Han, S. Chen,
S. C. Tseng. Research, Ocular Surface Ctr and
Tissue Tech, Miami, FL *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
135
Monday Posters
8:30 am – 10:15 am
1631 — D0266 Regional Variation of
Biomechanical Properties of Intact Eye Globes.
Ahmed Elsheikh1, 2, C. Whitford1, A. Joda1, A.
Abass1, F. Bao4, P. Rama3. 1Engineering, University
of Liverpool, Liverpool, United Kingdom; 2National
Institute for Health Research Biomedical Research
Centre at Moorfields Eye Hospital NHS Foundation
Trust and UCL Institute of Ophthalmology, London,
United Kingdom; 3Ophthalmology Department,
San Raffaelle Scientific Institute, Milan, Italy; 4Eye
Hospital, Wenzhou Medical College, Wenzhou,
China
1638 — D0273 Novel Corneal Biomechanical
Parameters in Myopes vs Emmetropes. Rachel
Lee1, R. Chang1, I. Y. Wong2, J. S. Lai2, J. W. Lee2,
K. Singh1. 1Stanford University School of Medicine,
Stanford, CA; 2Hong Kong University School of
Medicine, Hong Kong, Hong Kong *CR
1653 – 1676 – Monday – Posters
1653 — D0288 Human Corneal Endothelial
Cells Cytotoxicity Study Using a Custom
Chamber which Controls Temperature and
Oxygen Levels. Radha Pertaub, M. D. Friedman,
D. Muller. R&D, Avedro Inc, Waltham, MA *CR
Monday Posters
8:30 am – 10:15 am
1654 — D0289 A Nonsynthetic, Biological
Carrier for Cultivated Human Corneal
Endothelial Cells (HCECs) for potential
therapeutic purposes. Jesintha Navaratnam, E.
Gulliksen, K. Ustgaard-Andersen, J. K. Slettedal,
L. Drolsum, B. Nicolaissen, A. Shahdadfar. Center
for Eye Research, Oslo University Hospital, Oslo,
Norway
1655 — D0290 Differences in corneal
endothelial abnormalities in the central and
intermediate zones in Fuchs’ corneal dystrophy.
Hisataka Fujimoto, T. Soma, Y. Oie, S. Koh, M.
Tsujikawa, N. Maeda, K. Nishida. Osaka University,
Suita, Osaka, Japan *CR
1656 — D0291 Development and
Characterization of Decellularized Human
Corneal Stroma as a Scaffold for Tissue
Engineering. Radhika Tandon1, S. Mohanty2,
H. Singh1, D. Gupta3, S. Sen4, S. Kashyap4, A. K.
Dinda5, M. Jassal3, A. K. Agrawal3. 1Department
of Ophthalmology, Dr. Rajendra Prasad Centre for
Ophthalmic Sciences, All India Institute of Medical
Sciences, New Delhi, India; 2Stem Cell Facility,
All India Institute of Medical Sciences, New
Delhi, India; 3SMITA Research Labs, Department
of Textile, Indian Institute of Technology, New
Delhi, India; 4Department of Ocular Pathology,Dr.
Rajendra Prasad Centre for Ophthalmic Sciences,
All India Institute of Medical Sciences, New Delhi,
India; 5Department of Pathology, All India Institute
of Medical Sciences, New Delhi, India
1657 — D0292 Stemness Characteristics of
Cultured Human Corneal Endothelial Cells
in Various Media. Young Joo Shin1, E. Chung2,
T. Chung2, J. Hyon3, 4, W. Wee3. 1Ophthalmology,
Hallym University College of Medicine, Seoul,
Republic of Korea; 2Department of Ophthalmology,
Samsung Medical Center, Sungkyunkwan
University School of Medicine, Seoul, Republic
of Korea; 3Department of Ophthalmology, Seoul
National University College of Medicine, Seoul,
Republic of Korea; 4Department of Ophthalmology,
Seoul National University Bundang Hospital,
Seongnam, Republic of Korea
1658 — D0293 CD147 Knockdown Decreases
Corneal Lactate Transport and Endothelial
Cell Viability. Shimin Li, T. T. Nguyen, J. A.
Bonanno. School of Optometry, Indiana University,
Bloomington, IN
1659 — D0294 Disappearance and
reappearance of cilia of corneal endothelium
preserved in corneal preservation media.
Hidetoshi Tanioka, K. Shinomiya, S. Kawasaki, S.
Kinoshita. Ophthalmology, Kyoto Prefectural Univ
of Med, Kyoto, Japan *CR
1660 — D0295 Endothelial loss and
pachymetric change in patients undergoing
penetrating keratoplasty with 3 years of follow.
Elisa D. Alegria, R. Velasco, O. Baca, A. Babayan.
Cornea, Hosp Nuestra Senora De La Luz IAP,
Mexico, Mexico
1661 — D0296 The Resting Potential of Rat`s
Corneal Endothelial Cells. Nassim S. Calixto1,
V. V. Oliveira2, R. Fleming2, S. Cronemberger1, A.
Dantas2. 1Ophthalmology, Federal Univ of Minas
Gerais, Belo Horizonte, Brazil; 2Ophthalmology,
Federal University of Rio de Janeiro, Rio de
Janeiro, Brazil
1662 — D0297 Wnt5a enhances cell migration
through regulation of Cdc42 and RhoA pathway
in human corneal endothelial cells. JeongGoo
Lee1, D. Sand1, 2, J. M. Heur1, 2. 1Ophthalmology,
University of Southern California, Los Angeles,
CA; 2Doheny Eye Institute, Los Angeles, CA
1663 — D0298 Influence Of Hydrodynamic
Culture Conditions On The Expression Of
Cell Junctions Of Tissue-Engineered Human
Corneal Endothelium. Olivier Roy1, I. Brunette3, 4,
S. Proulx1, 2. 1LOEX/CUO - Recherche, Centre
de recherche du CHU, Quebec, QC, Canada;
2
Ophtalmologie, Université Laval, Quebec, QC,
Canada; 3Centre de recherche HMR, Montréal, QC,
Canada; 4Ophtalmologie, Université de Montréal,
Montréal, QC, Canada
1664 — D0299 The Quebec Corneal Cell
Bank: Update on Culture Success of Pathologic
Human Corneal Endothelial Cells (2009-2012).
Mathieu Theriault1, O. Roy1, O. Rochette-Drouin1,
M. Perron3, I. Brunette3, 4, S. Proulx1, 2. 1LOEX/CUO
- Recherche, Centre de recherche du CHU, Quebec,
QC, Canada; 2Ophtalmologie, Université Laval,
Quebec, QC, Canada; 3Centre de recherche HMR,
Montréal, QC, Canada; 4Ophtalmologie, Université
de Montréal, Montréal, QC, Canada
1665 — D0300 Perception of Cornea and
Glaucoma Subspecialists Regarding Prevalence
of Corneal Decompensation with Ex-Press Shunt
Placement. Shalin Shah1, N. Yen1, T. W. Hilary2,
J. S. Weiss1. 1Department of Ophthalmology,
Louisiana State University Eye Center, LSU School
of Medicine, LSU Health Sciences Center, New
Orleans, LA; 2Biostatistics Section, School of
Public Health, Louisiana State University Health
Sciences Center, New Orleans, LA
1666 — D0301 Biosafety of chitosan and
collagen vitrigel membranes in the corneal
endothelium of young New Zealand Rabbits.
Guillermo Mendoza1, J. Zavala1, M. GarzaMadrid1, 2, A. Tamez1, A. Zavala-Pompa1, G. Brito3,
J. A. Cortés_Ramirez3, J. E. Valdez1, J. Elisseeff2.
1
Ophthalmology Research Chair, Tecnológico de
Monterrey, Monterrey, Mexico; 2Translational
Tissue Engineering Center, Wilmer Eye Institute,
Johns Hopkins School of Medicine, Baltimore, MD;
3
Cátedra de Dispositivos Biomédicos, Tecnológico
de Monterrey, Monterrey, Mexico *CR
1667 — D0302 Examination of Endothelial
Cell Count in HIV-Negative and Positive Donors.
John A. Gonzales1, D. C. Gritz1, P. Gore2, R. S.
Chuck1. 1Department of Ophthalmology & Visual
Sciences, Montefiore Medical Center, New York,
NY; 2Lions Eye Institute, Saint Petersburg, FL
1668 — D0303 Morphological Complexity of
Mouse Corneal Endothelial Cells Revealed by
Mosaic Analysis. Dennis M. Defoe, W. J. Rich, T.
A. Harrison. Biomedical Sciences, East Tennessee
State University, Johnson City, TN
1669 — D0304 Systematic and individual
differences in donor cornea Endothelial Cell
Density (ECD) measurements with specular
microscopy vs. sucrose light microscopy. Bart
T. Van Dooren1, 2, I. J. Claerhout3, 4, P. G. Mulder5,
E. Pels6. 1Opththalmology, Amphia Hospital,
Breda, Netherlands; 2Ophthalmology, Erasmus
Medical Center, Rotterdam, Netherlands; 3Cornea
Bank, Ghent University Hospital, Ghent, Belgium;
4
Ophthalmology, Ghent University Hospital, Ghent,
Belgium; 5Amphia Academy, Amphia Hospital,
Breda, Netherlands; 6Cornea Bank, Euro Tissue
Bank, Beverwijk, Netherlands
1670 — D0305 Oxidative Stress Causes
Mitochondrial Dysfunction in Human Corneal
Endothelial Cells. Thore Schmedt1, 2, C. E.
Hamill1, 2, Y. Chen1, 2, U. V. Jurkunas1, 2. 1Schepens
Eye Research Inst, Boston, MA; 2Massachusetts
Eye and Ear, Boston, MA *CR
1671 — D0306 Theoretical and Clinical
Method to quantify the Corneal Suction
Pressure from normal corneas during the
lifetime. Andre Heck, F. C. Abib. Federal University
of Paraná, Curitiba, Brazil *CR
1672 — D0307 Descemet Membrane
Endothelial Keratoplasty (DMEK): Large
Descemetorhexis To Reduce Rebubbling Does
Not Cause Postoperative Peripheral Corneal
Edema. Theofilos Tourtas, J. M. Wessel, B. O.
Bachmann, U. Schlotzer-Schrehardt, F. E. Kruse.
Department of Ophthalmology, University of
Erlangen-Nuremberg, Erlangen, Germany
1673 — D0308 Objective Assessment of the
Corneal Endothelium in Fuchs Endothelial
Dystrophy. Jay W. McLaren, L. A. Bachman, S. V.
Patel. Ophthalmology, Mayo Clinic, Rochester, MN
1674 — D0309 Density dependency of
successful in vitro cultures of human corneal
endothelial cells using a dual media approach.
Gary S. Peh1, H. Ang1, K. Adnan1, X. Seah1, B. L.
George1, J. S. Mehta2, 3. 1Ocular Tissue Eng & Stem
Cell Group, Singapore Eye Research Institute,
Singapore, Singapore; 2Corneal and External Eye
Disease Service, Singapore National Eye Centre,
Singapore, Singapore; 3Department of Clinical
Sciences, Duke-NUS Graduate Medical School,
Singapore, Singapore *CR
1675 — D0310 SLC4A11 is an EIPA-sensitive
Na+-Dependent pHi Regulator. Diego G. Ogando1,
S. S. Jalimarada1, E. N. Vithana2, J. A. Bonanno1.
1
School of Optometry, Indiana University,
Bloomington, IN; 2Singapore Eye Research
Institute, Singapore, Singapore
1676 — D0311 Effects of the Reliability Index
called Sample Error of the corneal specular
microscopy on the repeatability of the results
of the examinations. Fernando C. Abib1, 2, R. Y.
Hida3, R. Holzchuh3. 1Anatomy, Federal University
of Parana, Curitiba, Brazil; 2Cornea, Clinica
de Olhos Dr. Fernando Abib, Curitiba, Brazil;
3
Ophthalmology, University of Sao Paulo, Sao
Paulo, Brazil *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
136
Monday – Posters – 1677 – 1698
1677 — D0312 Comparing Quantitative and
Qualitative Indices of the Donated Corneas
Maintained in Optisol GS with Those Kept
in Eusol C. Mozhgan Rezaei Kanavi1, 2, M.
Javadi1, 3, T. Chamani3, P. Fahim3. 1Ophthalmic
Research Center, Shahid Beheshti University of
Medical Sciences, Tehran, Islamic Republic of
Iran; 2Department of Ophthalmology and Visual
Sciences, University of Wisconsin, Madison, WI;
3
Central Eye Bank of Iran, Tehran, Islamic Republic
of Iran
1679 — D0314 Changes in Anterior Corneal
Haze with Severity of Fuchs Endothelial
Dystrophy. Sejal Amin, J. W. McLaren, K. H.
Baratz, S. V. Patel. Ophthalmology, Mayo Clinic,
Rochester, MN *CR
1680 — D0315 Cell Line of Fuchs’ Corneal
Dystrophy Produces an Abnormal Extracellular
Matrix. Leona Ho1, N. Okumura1, E. P. Kay1,
K. Yamasaki1, S. Kawasaki2, T. Tourtas3, U.
Schlotzer-Schrehardt3, F. E. Kruse3, S. Kinoshita2,
N. Koizumi1. 1Biomedical Engineering, Doshisha
University, Kyoto, Japan; 2Ophthalmology, Kyoto
Prefectural University of Medicine, Kyoto, Japan;
3
Ophthalmology, University of Erlangen-Nürnberg,
Erlangen, Germany *CR
1681 — D0316 Evaluation of Novel Porcine
Atelocollagen Vitrigel Membrane with
Curvature as Corneal Endothelial Cell Carrier.
Junko Yoshida1, S. Yokoo1, S. Yamagami1, S.
Amano1, A. Oshikata2, C. Okamoto2, T. Takezawa2.
1
Department of Ophthalmology, The University of
Tokyo, Graduate School of Medicine, Tokyo, Japan;
2
Division of Animal Sciences, National Institute of
Agrobiological Sciences, Tsukuba, Japan *CR
1682 — D0317 Prosthetic Replacement of
Ocular Surface Ecosystem (PROSE) Device
Wear Results in Decreased Endothelial
Cell Density and Decreased Endothelial
Pleomorphism. Ryan M. St Clair, Y. Wang, C.
E. Starr, M. N. Lee, A. G. Alzaga Fernandez, K.
C. Sippel, J. Ciralsky, M. Rosenblatt, P. Sood.
Ophthalmology, Weill Cornell Medical College,
New York, NY
1683 — D0318 Clinical Manifestation
and Effect of Ganciclovir Therapy for
Cytomegalovirus Corneal Endotheliitis. Tsutomu
Inatomi1, N. Koizumi2, Y. Ohashi3, Y. Inoue4, M.
Mochizuki5, K. Nishida6. 1Ophthalmology, Kyoto
Prefectural Univ of Med, Kamigyo-Ku, Japan;
2
Biomedical Engineering Faculty of Life and
Medical Sciences, Doshisha University, Kyoto,
Japan; 3Ophthalmology, Ehime University School
of Medicine, Ehime, Japan; 4Ophthalmology,
Tottori University, Faculty of Medicine, Tottori,
Japan; 5Ophthalmology, Tokyo Medical and
Dental University Graduate School, Tokyo, Japan;
6
Ophthalmology, Osaka University Graduate School
of Medicine, Osaka, Japan *CR
1685 — D0320 Meganuclease Targeting HSV-1
Protects Against Corneal Endothelitis ex-vivo
and in-vivo. Eric E. Gabison1, 2, M. Labetoulle4,
M. Gailledrat5, J. A. Sahel3, B. Chapelier3. 1Cornea
Department, Fondation A. de Rothschild, Paris,
France; 2Ophthalmology Department, Hôpital
Bichat, Paris, France; 3Institut de la vision, Paris,
France; 4Ophthalmology Department, Hôpital du
Kremlin Bicêtre, Paris, France; 5Cellectis, Paris,
France *CR
1686 — D0321 Comparison of Endothelial Cell
Density at the Central and Peripheral Regions in
a DSAEK Graft. Hiroko Nakagawa, T. Inatomi, S.
Kinoshita. Kyoto Prefectural Univ of Med, Kyoto,
Japan *CR
1687 — D0322 Age-Dependent Differential
Gene Expression in Human Corneal
Endothelium. Cynthia Wang, R. F. Frausto, A. J.
Aldave. Jules Stein Eye Institute, Los Angeles, CA
*CR
1688 — D0323 ROCK inhibitor enhances
adhesion and wound healing on human
corneal endothelial cells. Michael J. Nicolas1, A.
Pipparelli1, Y. Arsenijevic1, G. Thuret2, P. Gain2, F.
Majo1. 1Ophtalmology, Jules-Gonin eye hospital,
Lausanne, Switzerland; 2Ophtalmology, University
of St Etienne, St Etienne, France
1689 — D0324 Controlled Release of a Rho
Kinase (ROCK)-Selective Inhibitor with
Polylactic Acid Microspheres. Sho Koda1, 2, T.
Saito2, J. Kitano1, N. Okumura1, 3, S. Kinoshita3, Y.
Tabata2, N. Koizumi1, 3. 1Biomedical Engineering,
Doshisha University, Kyotanabe, Japan;
2
Biomaterials, Kyoto University, Kyoto, Japan;
3
Ophthalmology, Kyoto Prefectural University of
Medicine, Kyoto, Japan *CR
1690 — D0325 Rho-kinase inhibitor enhances
corneal endothelial cell proliferation via p27
degradation. Ryohei Numata1, 2, N. Okumura1, 2, E.
P. Kay1, M. Nakahara1, S. Nakano1, M. Ueno2, S.
Kinoshita2, N. Koizumi1. 1Biomedical Engineering,
Doshisha University, Kyotanabe, Japan;
2
Ophthalmology, Kyoto Prefectural University of
Medicine, Kyoto, Japan *CR
1692 — D0327 Cell-injection Therapy Using
Rho Kinase Inhibitor in a Corneal Endothelial
Dysfunction Rabbit Model. Junji Kitano1, N.
Okumura1, 2, E. P. Kay1, M. Ueno2, J. Hamuro2, S.
Kinoshita2, N. Koizumi1, 2. 1Biomedical Engineering,
Doshisha University, Kyotanabe, Japan;
2
Ophthalmology, Kyoto Prefectural University of
Medicine, Kyoto, Japan *CR
1693 — D0328 Effect of ROCK inhibiter
on Apoptosis in Corneal Endothelial Cells. Ai
Odajima1, 2, N. Okumura1, 2, E. P. Kay1, W. Chen1,
M. Ueno2, S. Kinoshita2, N. Koizumi1. 1Department
of Biomedical Engineering, Faculty of Life and
Medical Sciences, Doshisha University, Kyotanabe,
Japan; 2Department of Ophthalmology, Kyoto
Prefectural University of Medicine, Kyoto, Japan
*CR
1694 — D0329 Rho kinase inhibitor promotes
cell adhesion of corneal endothelial cells through
inhibiting phosphorylation of MLC. Yuki
Tsujimoto1, 2, N. Okumura1, 2, E. P. Kay1, R. Numata1,
S. Kinoshita2, N. Koizumi1. 1Biomed Eng, Doshisha
University, Kyotanabe, Japan; 2Ophthalmology,
Kyoto Prefectural University of Medicine, Kyoto,
Japan *CR
1695 — D0330 Quantitative Assessment of
Endothelial Cell Loss of DMEK Prepared Grafts
by Eye Bank Technicians. Jeffrey D. Holiman1, J.
Talajic2, D. Davis-Boozer1, 2, M. A. Terry2. 1Lions
VisionGift, Portland, OR; 2Devers Eye Institute,
Portland, OR *CR
1696 — D0331 Interleukin-1β enhances cell
migration through AP-1 and NF-κB pathway
dependent FGF2 expression in human corneal
endothelial cells. Daniel Sand, J. Lee, J. M. Heur.
Department of Ophthalmology, Keck School of
Medicine of the University of Southern California,
Los Angeles, CA
1697 — D0332 The roles of TWEAK in human
corneal endothelial cells. Masahiro Yamaguchi1, N.
Ebihara1, T. Funaki1, A. Murakami1, S. Yamagami2.
1
Ophthalmology, Juntendo University, Bunkyo-ku,
Japan; 2Ophthalmology, Tokyo University, Tokyo,
Japan *CR
1698 — D0333 The transparency
transcriptome: gene expression profile of human
corneal endothelial cells. Noelia J. Kunzevitzky1, 2,
K. Alvarez-Delfin1, R. M. Merkhofer1, A. D.
Weisman1, J. L. Goldberg1, 3. 1Bascom Palmer Eye
Institute & Interdisciplinary Stem Cell Institute,
University of Miami, Miami, FL; 2Emmetrope
Ophthalmics, Coral Gables, FL; 3Shiley Eye Center,
University of California San Diego, San Diego, CA
1691 — D0326 Proliferation Propensity of
Cultured Human Corneal Endothelial Cells
and Their Plasticity Dictated by Culture
Microenvironments. Munetoyo Toda1, K. Nakata1,
K. asada1, M. Hagiya1, M. Ueno1, N. Okumura2, N.
Koizumi2, J. Hamuro1, S. Kinoshita1. 1Department
of Ophthalmology, Kyoto Prefectural University
of Medicine, Kyoto, Japan; 2Department of
Biomedical Engineering, Doshisha University,
Kyoto, Japan *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
137
Monday Posters
8:30 am – 10:15 am
1678 — D0313 Clinical Evaluation of a Novel
Method to Generate Precut Tissue for Descemet
Membrane Endothelial Keratoplasty (DMEK).
Bjoern O. Bachmann1, U. Schlotzer-Schrehardt1, M.
Boergel2, F. E. Kruse1. 1Ophthalmology, University
Erlangen, Erlangen, Germany; 2German society for
tissue transplantation, Hannover, Germany
1684 — D0319 Expansion of corneal
endothelial cells using biomimetic engineered
substrates. Rachelle Palchesko1, 3, J. L.
Funderburgh2, 3, A. W. Feinberg1, 3. 1Biomedical
Engineering, Carnegie Mellon University,
Pittsburgh, PA; 2Ophthalmology, University of
Pittsburgh, Pittsburgh, PA; 3Louis J Fox Center
for Vision Restoration, University of Pittsburgh,
Pittsburgh, PA *CR
1699 – 1714 – Monday – Papers
6A
6B
Monday, May 06, 2013 11:00 AM-12:45 PM
Monday, May 06, 2013 11:00 AM-12:45 PM
Biochemistry/Molecular Biology
Glaucoma
240 Visual Cycle, Retinoids and
Carotenoids
241 Imaging I, GL
Monday Papers
11:00 am – 12:45 pm
Moderators: Vladimir J. Kefalov and
Krysten M. Farjo
1699 — 11:00 Mouse Cone Dark Adaptation
Relies on Two Visual Cycles and Is Substantially
Retarded in Mice Lacking RDH8 and ABCA4.
Alexander V. Kolesnikov1, P. H. Tang2, A. Maeda3,
L. C. Byrne4, J. G. Flannery4, K. Palczewski3, V.
J. Kefalov1. 1Ophthalmology and Visual Sciences,
Washington University School of Medicine, Saint
Louis, MO; 2Ophthalmology, Medical University
of South Carolina, Charleston, SC; 3Pharmacology,
Case Western Reserve University, Cleveland, OH;
4
Molecular and Cell Biology, The University of
California, Berkeley, CA *CR
1700 — 11:15 Identification and Study of
Two New 11-cis-Retinyl Ester Synthases in the
Retina. Joanna J. Kaylor1, J. Makshanoff1, J.
Yong1, T. N. Nguyen1, R. A. Radu1, G. H. Travis1, 2.
1
Ophthalmology, UCLA-Jules Stein Eye Institute,
Los Angeles, CA; 2Biological Chemistry, UCLA,
Los Angeles, CA
1701 — 11:30 Substrate Specificity and
Localization of AL-OL Coupling Reaction in
Carp Cones. Satoru Kawamura1, 2, S. Sato2, S.
Tachibanaki1, 2, T. Fukagawa1. 1Grad Sch of Frontier
Biosci, Osaka Univ, Suita, Japan; 2Dept of Biol Sci,
Faculty of Sci, Osaka Univ, Toyonaka, Japan
1702 — 11:45 Targeting the STRA6/
RBP4 Binding interaction to Treat Macular
Degeneration. Krysten M. Farjo, G. P. Moiseyev, J.
Ma. Physiology, Univ of Oklahoma Hlth Sciences,
Oklahoma City, OK *CR
1703 — 12:00 Evaluation of different classes
of RBP4 antagonists as potential treatments
for AMD. Nicoleta Dobri1, Q. Qin1, J. Kong1,
R. Allikmets1, 2, J. R. Sparrow1, 2, K. Petrukhin1.
1
Ophthalmology, Columbia University, New York,
NY; 2Pathology, Columbia University, New York,
NY
1704 — 12:15 Bestrophinopathy Large Animal
Model Shows Abnormal Accumulation of
Lipofuscin in the Retinal Pigment Epithelium.
Nestor Mas Gomez1, E. V. Dutrow1, S. Iwabe1, F.
P. Stefano2, K. Boesze-Battaglia2, G. D. Aguirre1,
K. E. Guziewicz1. 1Department of Clinical Studies,
University of Pennsylvania, Philadelphia, PA;
2
Department of Biochemistry, University of
Pennsylvania, Philadelphia, PA
Moderators: Jeffrey M. Liebmann, David F.
Garway-Heath and David S. Greenfield
1706 — 11:00 Rates of retinal nerve fiber layer
thinning in glaucoma suspect eyes. Atsuya Miki1,
L. M. Zangwill1, S. Jain2, F. He2, N. Khachatryan1,
N. Hammel1, J. M. Liebmann3, 4, C. A. Girkin5, F.
A. Medeiros1, R. N. Weinreb1. 1Hamilton Glaucoma
Center, Department of Ophthalmology, University
of California, San Diego, La Jolla, CA; 2Department
of Family and Preventive Medicine, University of
California, San Diego, La Jolla, CA; 3Department
of Ophthalmology, New York University School
of Medicine, New York, NY; 4Department of
Ophthalmology, Einhorn Clinical Research Center,
New York Eye and Ear Infirmary, New York, NY;
5
Department of Ophthalmology, University of
Alabama at Birmingham, Birmingham, AL *CR, f
1707 — 11:15 Parapapillary Autofluorescence
and its Correlation with Neurovascular Fundus
Anomalies in Primary Open Angle Glaucoma.
Alexandre Plouznikoff1, P. Harasymowycz2, 3.
1
Faculty of medicine, Laval University, Quebec,
QC, Canada; 2Faculty of medicine, University
of Montreal, Montreal, QC, Canada; 3Institute of
glaucoma, Montreal, QC, Canada *CR
1708 — 11:30 3T Magnetic Resonance Imaging
of the Posterior Visual Pathway in Early
and Advanced Human Primary Open Angle
Glaucoma. Heather R. Connor1, S. L. Hosking2, 3,
J. Tournier4, 5, D. F. Abbott4, 5. 1Ophthalmology,
University of Melbourne, Melbourne, VIC,
Australia; 2Optometry and Vision Sciences,
University of Melbourne, Melbourne, VIC,
Australia; 3Optometry and Visual Science, City
University, London, United Kingdom; 4Brain
Research Institute, Florey Institute of Neuroscience
and Mental Health, Heidelberg, VIC, Australia;
5
Medicine, Dentistry and Health Sciences,
University of Melbourne, Melbourne, VIC,
Australia
1709 — 11:45 Spectral Domain Optical
Coherence Tomography (SDOCT) Optic Nerve
Head (ONH) Rim Quantification in Glaucoma
and Glaucoma Suspect Eyes Using Anatomic Vs
Acquired Image Frame (AIF) Regionalization.
Lin He, R. Ren, C. A. Hardin, H. Yang, S. K.
Gardiner, B. Fortune, S. Demirel, C. F. Burgoyne.
Devers Eye Institute, Legacy Research Institute,
Portland, OR *CR
1710 — 12:00 Subgrouping of Angle Closure
Patients based on Anterior Segment Optical
Coherence Tomography Parameters. Tin
Aung1, 2, T. Gong3, H. Lee3, S. Perera1, M. He4,
D. S. Friedman5, M. E. Nongpiur1, 2. 1Glaucoma,
Singapore National Eye Center, Singapore,
Singapore; 2Yong Loo Lin School of Medicine,
National University of Singapore, Singapore,
Singapore; 3Bioinformatics Institute, A*STAR
(Agency for Science, Technology and Research),
Singapore, Singapore, Singapore; 4State Key
Laboratory of Ophthalmology, Zhongshan
Ophthalmic Center, Sun Yat-sen University,
Guangzhou, China; 5Wilmer Eye Institute, Dana
Center for Preventive Ophthalmology, Johns
Hopkins University, Baltimore, MD *CR
1711 — 12:15 In vivo changes to lamina
cribrosa pore and optic nerve head geometry in
non-human primates with early experimental
glaucoma. Kevin M. Ivers1, N. Sredar2, N. B.
Patel1, L. P. Rajagopalan1, H. M. Queener1, R.
S. Harwerth1, J. Porter1. 1College of Optometry,
University of Houston, Houston, TX; 2Department
of Computer Science, University of Houston,
Houston, TX
1712 — 12:30 Pulse-induced Optic Nerve Head
Axial Movement: Characterization by Phasesensitive OCT in Humans. Ruikang K. Wang1, 2,
L. an1, P. Li1, M. A. Johnstone2. 1Bioengineering,
University of Washington, Seattle, WA;
2
Ophthalmology, University of Washington, Seattle,
WA *CR
6C
Monday, May 06, 2013 11:00 AM-12:45 PM
Retina
242 AMD: Translational Research
Moderators: Peter K. Kaiser and David M. Brown
1713 — 11:00 Interleukin-17 neutralization
ameliorates retinal degeneration in Cx3cr1-/-/
Ccl2-/-/Crb1rd8 mice. Daniel Ardeljan1, Y.
Wang2, 3, D. Shen2, M. S. Abu-Asab4, J. Tuo2, C. Yu5,
G. White6, S. Wadsworth6, A. Scaria6, C. Chan2, 4.
1
Johns Hopkins University School of Medicine,
Baltimore, MD; 2Laboratory of Immunology,
Immunopathology Section, National Eye Institute,
Bethesda, MD; 3Department of Ophthalmology,
Sun-Yat Sen University, Guangzhou, China;
4
Histology Core, National Eye Institute,
Bethesda, MD; 5Laboratory of Immunology,
Molecular Immunology Section, National Eye
Institute, Bethesda, MD; 6Genzyme Corporation,
Framingham, MA *CR
1714 — 11:15 Oral administration of
Apolipoprotein A-I mimetic peptide D-4F
reduces lipid accumulation in murine Bruch’s
membrane (BrM). Martin Rudolf1, A. Mohi1, Z.
Aherrahrou2, S. Grisanti1, Y. Miura1, 3. 1Department
of Opthalmology, University of Luebeck,
Luebeck, Germany; 2Institute for Integrative and
Experimental Genomics, University of Luebeck,
Luebeck, Germany; 3Institue of Biomedical Optics,
University of Luebeck, Luebeck, Germany *CR
1705 — 12:30 Delivery of Zeaxanthin to the
Mouse Retina. Binxing Li, P. P. Vachali, Z. Shen,
B. M. Besch, P. S. Bernstein. University of Utah,
Moran Eye Center, Salt Lake City, UT *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
138
Monday – Papers – 1715 – 1732
1715 — 11:30 Effect of Aspirin on human
ARPE-19 cells and in Mouse Model of
Choroidal Neovascularization. Sunali Goyal, V. V.
Lyzogubov, P. S. Bora, N. S. Bora, S. H. Uwaydat.
Ophthalmology, Jones Eye Institute, University of
Arkansas for Medical Sciences, Little Rock, AR
1721 — 11:30 Correlation of Number of
Microaneurysms with Retinal Thickness. Beng
Beng Ong1, 2, J. Arora2, A. Hammond-Kenny2, J.
Doyle1, S. Izadi1, C. A. Kiire1, V. Chong1, 2. 1Oxford
Eye Hospital, Oxford, United Kingdom; 2Oxford
University, Oxford, United Kingdom *CR
1716 — 11:45 Eyedrop application of CLT005, a Stat3 inhibitor, is efficacious in animal
models of Wet and Dry Age-related Macular
Degeneration. Rafal Farjo1, D. J. Nuno1, A. B.
Quiambao1, P. A. Vanlandingham1, F. Mondalek1,
E. Phelps1, G. Stoller2, D. Wassel1. 1Charlesson,
Oklahoma City, OK; 2SKS Ocular, Great Neck, NY
*CR
1722 — 11:45 AGE products disrupt RPE
barrier function in vitro and in vivo. Mohammad
Dahrouj, Y. Liu, C. E. Crosson, Z. Ablonczy.
Ophthalmology, Medical Univ of South Carolina,
Charleston, SC *CR
1718 — 12:15 Intraocular Delivery of Ciliary
Neurotrophic Factor (CNTF) by Encapsulated
Cell Technology Implants Restores Cone
Function and Day Vision in Dogs with CNGB3Achromatopsia. Andras M. Komaromy1, 2, K. L.
Koehl1, C. Harman1, P. Heatherton3, K. Kauper3,
G. D. Aguirre2, W. Tao3. 1Small Animal Clinical
Studies, Michigan State Univ, Coll of Vet Med, East
Lansing, MI; 2Clinical Studies, Univ Pennsylvania,
School of Vet Med, Philadelphia, PA; 3Neurotech
Pharmaceuticals, Inc., Cumberland, RI *CR
6E
Monday, May 06, 2013 11:00 AM-12:45 PM
Retina
243 DR: Factors and Function
Moderators: Jennifer J. Kang Mieler and
Ursula Schmidt-Erfurth
1719 — 11:00 Patterns of Progression in
Diabetic Retinopathy. Correlation between
phenotypes and genotypes. Sandrina Nunes1, 2, C.
F. Lobo1, 2, L. Ribeiro1, 2, I. Pires1, 2, R. Bernardes1, 2,
T. Miranda1, M. J. Simões3, C. Faro3, J. G. CunhaVaz1, 2. 1AIBILI, Coimbra, Portugal; 2FMUC,
University of Coimbra, Coimbra, Portugal;
3
BIOCANT, Coimbra, Portugal *CR, f
1720 — 11:15 Neuroretinal Function and
Retinal Vessel Changes over One Year Are
Altered by Long-Term Blood Glucose Change in
Adolescent Type 1 Diabetes. Marcus A. Bearse, M.
Laron, A. Chang, K. Bronson-Castain, B. E. Wolff,
G. Y. Ozawa, S. Barez, M. E. Schneck, A. J. Adams.
School of Optometry, University of California,
Berkeley, CA
1724 — 12:15 Structural Characteristics
of Microaneurysms on Adaptive Optics
Scanning Laser Ophthalmoscopy (AOSLO)
and Surrounding Neural Retinal Pathology in
Diabetes. Jennifer K. Sun1, 2, J. Lammer1, 4, S. G.
Prager1, 4, M. M. Lin1, 5, M. C. Cheney1, P. S. Silva1, 2,
S. A. Burns3, L. P. Aiello1, 2. 1Beetham Eye Institute,
Joslin Diabetes Center, Boston, MA; 2Department of
Ophthalmology, Harvard Medical School, Boston,
MA; 3School of Optometry, Indiana University,
Bloomington, IN; 4Department of Ophthalmology
and Optometry, Medical University of Vienna,
Vienna, Austria; 5Harvard Medical School, Boston,
MA *CR
1725 — 12:30 Peripheral Diabetic Retinal
Lesions Identified on Ultrawide Field (UWF)
Imaging May Predict 3-Year Diabetic
Retinopathy Progression. Paolo S. Silva1, 2, J.
Cavallerano1, 2, J. K. Sun1, 2, L. M. Aiello1, 2, L. P.
Aiello1, 2. 1Beetham Eye Institute, Joslin Diabetes
Center, Boston, MA; 2Ophthalmology, Harvard
Medical School, Boston, MA *CR
606/607
Monday, May 06, 2013 11:00 AM-12:45 PM
Immunology/Microbiology
244 Microbial Pathogenesis
Moderators: Jennifer H. LaVail and
Homayon Ghiasi
1726 — 11:00 Comparative Genome
Sequencing to Identify Staphylococcus aureus
Virulence and Antibiotic Resistance Genes
causing Keratitis. Irmgard Behlau1, 2, D. Lazinski1,
J. Martin1, 2, S. Heimer2, E. M. Leonard2, A. Wright1,
M. S. Gilmore2, C. H. Dohlman2, A. Camilli1.
1
Molecular Biology & Microbiology, Sackler
School of Biomedical Sciences - Tufts University
School of Medicine, Boston, MA; 2Ophthalmology,
Massachusetts Eye and Ear Infirmary/Schepens
Eye Research Institute - Harvard Medical School,
Boston, MA *CR
1728 — 11:30 Matrix Metalloproteinase 13 as a
target for suppressing corneal ulceration caused
by Pseudomonas aeruginosa infection. Nan Gao,
F. X. Yu. Ophthalmology, Wayne State Univ/Kresge
Eye Inst, Detroit, MI
1729 — 11:45 Loss of HSV-1 induced
VEGF-A during acute infection impairs the
lymphangiogenic response during later stages
of disease. Katie M. Hudson1, M. Zheng1, D. J.
Carr1, 2. 1Ophthalmology, University of Oklahoma
Health Sciences Center, Oklahoma City, OK;
2
Microbiology and Immunology, University of
Oklahoma Health Sciences Center, Oklahoma City,
OK
1730 — 12:00 Delivery of Herpes Simplex
Virus DNA to Retinal Ganglion Cell Axon
is Dependent on Viral Protein Us9. Jennifer
H. LaVail1, J. M. Draper1, G. S. Stephenson1,
G. Huang1, A. S. Bertke2, D. A. Cortez1. 1Dept
of Anatomy/Ophthalmology, University of
California, San Francisco, San Francisco, CA;
2
Proctor Foundation, University of California, San
Francisco, San Francisco, CA
1731 — 12:15 Signal peptide peptidase (SPP)
is required for HSV-1 infectivity through
interaction with glycoprotein K (gK). Sariah
J. Allen1, K. R. Mott1, Y. Matsuura2, K. Moriishi3,
K. G. Kousoulas4, H. Ghiasi1. 1Center for
Neurobiology & Vaccine Development, Department
of Surgery, Cedars-Sinai Medical Center, Los
Angeles, CA; 2Research Institute for Microbial
Diseases, Osaka University, Osaka, Japan;
3
Department of Microbiology, Faculty of Medicine
Yamanashi University, Yamanashi, Japan; 4Division
of Biotechnology and Molecular Medicine, School
of Veterinary Medicine, Baton Rouge, LA
1732 — 12:30 Prevention of CytomegalovirusInduced Retinitis By Intravenous Administration
of Virus-specific siRNA. Brendan Marshall, J.
Covar, S. S. Atherton, M. Zhang. Cellular Biology
and Anatomy, Georgia Health Sciences University,
Augusta, GA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
139
Monday Papers
11:00 am – 12:45 pm
1717 — 12:00 In vivo imaging of complement
activation in mouse choroidal neovascularization
using a novel monocolonal antibody against
the C3 activation fragment C3d. Baerbel
Rohrer1, 3, A. S. Woodell2, 1, L. Kulik4, B. Coughlin1,
G. Schnabolk3, J. M. Thurman4, M. Holers4.
1
Ophthalmology, Med Univ of South Carolina,
Charleston, SC; 2Neurosciences, Med Univ of South
Carolina, Charleston, SC; 3Research Services, Ralph
H Johnson VA Medical Center, Charleston, SC;
4
Medicine, University of Colorado Health Sciences
Center, Aurora, CO *CR
1723 — 12:00 Biomarkers of Retina Macroglia
Activation in the Aqueous of Human Diabetics.
Edoardo Midena1, 2, M. Berton1, S. Bini1, A. Micera2,
G. Esposito2, S. Vujosevic1. 1Ophthalmology,
University of Padova, Padova, Italy; 2GB Bietti
Foundation, IRCCS, Roma, Italy
1727 — 11:15 Efficacy of an Intravitreal
Levofloxacin Implant in an Animal Model of
Endophthalmitis. Russell Tait1, 4, R. Prankerd4, R.
Robins-Browne3, P. J. Allen5, 2, A. Donohue1, 4, D.
Yang2, 6, L. Adams3, F. Wang4, A. D’Souza1, S. Ng1.
1
PolyActiva Pty Ltd, Melbourne, VIC, Australia;
2
Centre for Eye Research Australia, Melbourne,
VIC, Australia; 3Microbiology and Immunology,
The University of Melbourne, Melbourne, VIC,
Australia; 4Monash Institute of Pharmaceutical
Sciences, Monash University, Melbourne, VIC,
Australia; 5Royal Victorian Eye and Ear Hospital,
Melbourne, VIC, Australia; 6Eye Hospital, Harbin
Medical University, Harbin, China *CR
1733 – 1740 – Monday – Papers
615-617
Monday, May 06, 2013 11:00 AM-12:45 PM
Clinical/Epidemiologic Research
245 Genetic Epidemiology: GWAS and
SNPs Around the World
Monday Papers
11:00 am – 12:45 pm
Moderators: Ching-Yu Cheng and Pirro G. Hysi
1733 — 11:00 The Consortium for Refractive
Error and Myopia (CREAM) Identifies
Four New Loci for Ocular Axial Length and
Demonstrates Shared Loci for Axial Length
and Refractive Error through Genome-Wide
Association Studies. Ching-Yu Cheng1, 2, M.
Schache3, M. K. Ikram1, 2, J. A. Guggenheim4, D.
Stambolian5, C. C. Klaver6, 7, Y. Teo8, 9, S. Saw8, 1,
P. N. Baird3, 10. 1Department of Ophthalmology,
National University of Singapore and National
University Health System, Singapore, Singapore;
2
Singapore Eye Research Institute, Singapore,
Singapore; 3Ocular Genetics Unit, Centre for Eye
Research Australia, University of Melbourne,
Royal Victorian Eye and Ear Hospital, Melbourne,
VIC, Australia; 4Centre for Myopia Research,
School of Optometry, The Hong Kong Polytechnic
University, Hong Kong, Hong Kong; 5Department
of Ophthalmology, University of Pennsylvania,
Philadelphia, PA; 6Department of Ophthalmology,
Erasmus Medical Center, Rotterdam, Netherlands;
7
Department of Epidemiology, Erasmus Medical
Center, Rotterdam, Netherlands; 8Saw Swee Hock
School of Public Health, National University of
Singapore, Singapore, Singapore; 9Department
of Statistics and Applied Probability, National
University of Singapore, Singapore, Singapore;
10
Department of Ophthalmology, Centre for Eye
Research Australia, University of Melbourne, Royal
Victorian Eye and Ear Hospital, Melbourne, VIC,
Australia *CR
1734 — 11:15 Heritability Estimation of Axial
Length and Refractive Error Explained by
Genome-Wide Single Nucleotide Polymorphisms.
Masahiro Miyake1, 2, K. Yamashiro1, H. Nakanishi1, 2,
I. Nakata1, 2, Y. Akagi-Kurashige1, 2, K. Kumagai1,
A. Tsujikawa1, R. Yamada2, F. Matsuda2, N.
Yoshimura1. 1Department of Ophthalmology, Kyoto
Univ Grad Sch of Medicine, Sakyoku, Kyoto City,
Japan; 2Center for Genomic Medicine, Kyoto Univ
Grad Sch of Medicine, Sakyoku, Kyoto City, Japan
*CR
1735 — 11:30 Meta-analysis of functional
enrichment results from five GWAS studies
reveals biological processes involved in human
refractive variation. Robert Wojciechowski1, 2,
K. Oexle3, C. L. Simpson2, J. E. Bailey-Wilson2, J.
S. Rahi4, C. J. Hammond6, D. Stambolian7, P. G.
Hysi5. 1Epidemiology, Johns Hopkins School of
Public Health, Baltimore, MD; 2Inherited Disease
Research Branch, National Human Genome
Research Institute, Baltimore, MD; 3Institute of
Human Genetics, Technische Universität München,
Munich, Germany; 4Institutes of Child Health
and Ophthalmology, University College London,
London, United Kingdom; 5Twin Research &
Genetic Epidemiology, King’s College London,
London, United Kingdom; 6Ophthalmology,
King’s College London, London, United Kingdom;
7
Ophthalogy-Stellar Chance Lab, University of
Pennsylvania, Philadelphia, PA
1736 — 11:45 Genome-wide Meta-Analyses
Of Multi-Ethnic Cohorts Identify Multiple New
Susceptibility Loci For Refractive Error And
Myopia. Virginie J. Verhoeven1, P. G. Hysi2, R.
Wojciechowski3, 4, J. A. Guggenheim5, S. Saw6, 7, J.
E. Bailey-Wilson3, D. Stambolian8, C. C. Klaver1,
C. J. Hammond2. 1Ophthalmology/Epidemiology,
Erasmus Medical Center, Rotterdam, Netherlands;
2
Twin Research and Genetic Epidemiology, King’s
College London School of Medicine, London,
United Kingdom; 3Inherited Disease Research
Branch, National Human Genome Research
Institute, National Institutes of Health, Baltimore,
MD; 4Epidemiology, Johns Hopkins Bloomberg
School of Public Health, Baltimore, MD; 5Centre
for Myopia Research, School of Optometry, The
Hong Kong Polytechnic University, Hong Kong,
Hong Kong; 6Saw Swee Hock School of Public
Health and department of Ophthalmology, National
University Health Systems, National University of
Singapore, Singapore, Singapore; 7Singapore Eye
Research Institute, Singapore National Eye Centre,
Singapore, Singapore; 8Ophthalmology, University
of Pennsylvania, Philadelphia, PA *CR
1737 — 12:00 International meta-analysis
of genetic factors influencing intraocular
pressure: the International Glaucoma Genetics
Consortium Study. Pirro G. Hysi1, C. Cheng2,
T. Aung2, J. E. Craig6, C. J. Hammond1, A. J.
Lotery5, N. Pfeiffer4, C. M. van Duijn3, A. C.
Viswanathan8, J. L. Wiggs7. 1Twin Research &
Genetic Epidemiology, King’s College London,
London, United Kingdom; 2Eye Research Institute,
National University of Singapore, Singapore,
Singapore; 3Department of Epidemiology and
Clinical Genetics, Erasmus University Medical
Centre, Rotterdam, Netherlands; 4Department of
Ophthalmology, Johannes Gutenberg University
Medical Centre, Mainz, Germany; 5Clinical
Neurosciences Research Grouping, Clinical and
Experimental Sciences, Faculty of Medicine,
University of Southampton, Southampton General
Hospital, Southampton, Southampton, United
Kingdom; 6Department of Ophthalmology, Flinders
University, Adelaide, SA, Australia; 7Department of
Ophthalmology, Mass Eye & Ear Infirmary, Harvard
Medical School, Harvard University, Boston,
MA; 8UCL Institute of Ophthalmology, University
College London, London, United Kingdom *CR
1738 — 12:15 An International Genome-Wide
Association Study of Glaucoma-Related Optic
Disc Parameters in 18,000 Caucasians: the
International Glaucoma Genetics Consortium.
Henriet Springelkamp1, R. Hoehn2, C. J. Hammond3,
A. W. Hewitt4, C. C. Klaver1, S. MacGregor5,
D. A. Mackey6, P. Mitchell7, T. Y. Wong8, C. M.
van Duijn9. 1Ophthalmology & Epidemiology,
Erasmus Medical Center, Rotterdam, Netherlands;
2
Department of Ophthalmology, University Medical
Center Mainz, Mainz, Germany; 3Department of
Twin Research and Genetic Epidemiology, King’s
College London School of Medicine, St Thomas’
Hospital, London, United Kingdom; 4Centre for
Eye Research Australia, University of Melbourne,
Royal Victorian Eye and Ear Hospital, Melbourne,
VIC, Australia; 5Queensland Institute of Medical
Research, Brisbane, QLD, Australia; 6Lions Eye
Institute, University of Western Australia, Centre
for Ophthalmology and Visual Science, Perth, WA,
Australia; 7Centre for Vision Research, Department
of Ophthalmology and Westmead Millennium
Institute, University of Sydney, Westmead, United
Kingdom; 8Singapore Eye Research Institute,
National University of Singapore, Singapore,
Singapore; 9Epidemiology, Erasmus Medical
Center, Rotterdam, Netherlands *CR
1739 — 12:30 Methylation landscape of
ocular tissue and their correlation to peripheral
leucocytes. Alex W. Hewitt1, 2, J. E. Joo3, J.
Wang1, J. E. Craig4, R. Saffery3. 1Department of
Ophthalmology, Centre for Eye Research Australia,
Surrey Hills, VIC, Australia; 2Lions Eye Institute,
University of Western Australia, Perth, WA,
Australia; 3Murdoch Childrens Research Institute,
The Royal Children’s Hospital, Melbourne, VIC,
Australia; 4Department of Ophthalmology, Flinders
University of South Australia, Adelaide, SA,
Australia
TCC LL 4/5
Monday, May 06, 2013 11:00 AM-12:45 PM
Visual Psychophysics / Physiological Optics
246 Cone Photoreceptors in Aging
and Disease
Moderators: Mark E. Pennesi and Ann E. Elsner
1740 — 11:00 Cone Distribution Variations for
Young Healthy Subjects vs. Older Subjects. Ann
E. Elsner1, T. Y. Chui1, L. Feng1, 2, C. M. McIntyre1,
H. Song1, 3, T. Gast1, S. A. Burns1. 1Optometry,
Indiana University, Bloomington, IN; 2Second
Affiliated Hospital, College of Medicine, Zhejiang
University, Zhejiang, China; 3Center for Visual
Science, University of Rochester, Rochester, NY
*CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
140
Monday – Papers – 1741 – 1760
1741 — 11:15 Longitudinal Cone Density
Measurements using a Commercially Available
Flood-Illuminated Adaptive Optics Camera in
Japanese Macaque Monkeys with Dominantly
Inherited Drusen. Mark E. Pennesi1, K. V.
Michaels1, S. Feng1, T. B. Smith1, A. K. Garg1,
T. J. McGill2, L. Renner2, M. Sperling3, K. D.
Rittenhouse3, M. Neuringer2. 1Ophthalmology,
Casey Eye Institute - OHSU, Portland, OR;
2
Division of Neuroscience, Oregon National
Primate Center, Beaverton, OR; 3External R&D
Innovations, Pfizer Inc., San Diego, CA *CR
1743 — 11:45 Adaptive Optics Scanning
Laser Ophthalmoscopy in Stargardt Disease
Reveals Decreased Cone and Rod Densities.
Hongxin Song1, A. Pugliese2, E. A. Rossi1, L. R.
Latchney2, E. M. Stone3, A. Dubra4, J. J. Hunter1, 2,
M. M. Chung1, 2. 1Center for Visual Science,
University of Rochester, Rochester, NY; 2Flaum Eye
Institute, University of Rochester, Rochester, NY;
3
Ophthalmology and Visual Science, University of
Iowa, Iowa City, IA; 4Ophthalmology, University of
Wisconsin, Milwaukee, WI *CR
1744 — 12:00 Cone structure imaged
with Adaptive Optics Scanning Laser
Ophthalmoscopy in eyes with Non-Neovascular
Age-related Macular Degeneration. Shiri ZayitSoudry1, R. Syed1, K. Ratnam1, M. Menghini1, A.
Roorda2, J. L. Duncan1. 1Ophthalmology/Retina
Division, University of California, San Francisco,
San Francisco, CA; 2School of Optometry,
University of California, Berkeley, Berkeley, CA
*CR
1745 — 12:15 Adaptive Optics Imaging
of Photoreceptors following Repair of
Rhegmatogenous Retinal Detachments.
Meenakashi Gupta1, M. Dubow1, 2, A. Pinhas1, 2,
N. Shah1, P. Garcia1, G. Landa1, Y. N. Sulai3, A.
Dubra4, R. B. Rosen1. 1New York Eye and Ear
Infirmary, New York, NY; 2Mount Sinai School of
Medicine, Mount Sinai Hospital, New York, NY;
3
University of Rochester, Rochester, NY; 4Medical
College of Wisconsin, Madison, WI *CR
1746 — 12:30 Changes in Cone Reflectivity
and Regularity Assessed by Adaptive Optics
Scanning Laser Ophthalmoscopy (AOSLO)
Correlate with Presence of Diabetic Retinopathy.
Jan Lammer1, 2, A. Ahmed5, S. G. Prager1, 2, M. C.
Cheney1, S. A. Burns4, P. S. Silva1, 3, L. P. Aiello1, 3,
J. K. Sun1, 3. 1Beetham Eye Institute, Joslin Diabetes
Center, Boston, MA; 2Department of Opthalmology
and Optometry, Medical University of Vienna,
Vienna, Austria; 3Department of Ophthalmology,
Harvard Medical School, Boston, MA; 4School of
Optometry, Indiana University, Bloomington, IN;
5
Department of Histology and Cell Biology, Faculty
of Medicine, Assiut University, Assiut, Egypt *CR
TCC 304
Monday, May 06, 2013 11:00 AM-12:45 PM
Monday, May 06, 2013 11:00 AM-12:45 PM
Cornea
Visual Neuroscience
247 Surgery: Non-Refractive
and Keratoprothesis
248 Synaptic Mechanisms, Ion
Channels and Gap Junctions
Moderators: Frank Larkin, Mark A. Terry and
Sanjay V. Patel
Moderators: Jeff Diamond and Steven A. Barnes
1747 — 11:00 Microstructural analysis of the
cornea after Descemet membrane endothelial
keratoplasty using in vivo confocal microscopy.
Akira Kobayashi, H. Yokogawa, N. Yamazaki, T.
Masaki, K. Sugiyama. Dept of Ophthalmology,
Kanazawa Univ Sch of Medicine, Kanazawa, Japan
1748 — 11:15 Impact of Donor Age on
Endothelium-Descemet Membrane Layer
Harvesting and Roll Formation. Adam Bennett1,
S. Rashad2, D. Drury1, H. D. Cavanagh1, J. P.
McCulley1, M. Petroll1, V. V. Mootha1. 1Univ
Tex Southwestern Medical Center, Dallas, TX;
2
Alexandria Faculty of Medicine, Alexandria, Egypt
*CR
1749 — 11:30 Descemet’s Stripping Automated
Endothelial Keratoplasty (DSAEK) vs UltraThin DSAEK (UT-DSAEK) vs Descemet’s
Membrane Endothelial Keratoplasty (DMEK).
Peng Yan, S. Teja, K. Baig. Ophthalmology,
University of Ottawa - Eye Institute, Ottawa, ON,
Canada *CR
1750 — 11:45 Diamond knife assisted Deep
Anterior Lamellar Keratoplasty (Dia-DALK):
A new surgical technique for management of
Keratoconus. Rasik B. Vajpayee, P. K. Maharana,
N. Sharma. R P centre for Ophthalmic Sciences,
All India Institute of Medical Sciences, New Delhi,
India
1751 — 12:00 Femtosecond Laser-Assisted
Deep Anterior Lamellar Keratoplasty with Zigzag Configuration: Initial Outcomes. Ijeoma
Asota, M. Wade, J. Xie, S. Garg, R. F. Steinert, M.
Farid. Gavin Herbert Eye Institute, University of
California Irvine, Irvine, CA *CR
1752 — 12:15 Corneal Endothelial Cell Loss
after Endothelial and Penetrating Keratoplasty
for Endothelial Disease. Sanjay V. Patel, K. H.
Baratz, J. W. McLaren, L. A. Bachman, W. M.
Bourne. Ophthalmology, Mayo Clinic, Rochester,
MN *CR, f
1753 — 12:30 Outcomes of new partialthickness corneal grafts: a paradigm shift in
practice, but at what cost. Richard A. Mills, M.
C. Keane, K. Williams. Dept of Ophthalmology,
Flinders University SA, Bedford Park, SA, Australia
1754 — 11:00 Tiered cross-class bipolar cell
gap junctional coupling in the rabbit retina. J
Scott Lauritzen, J. V. Hoang, C. L. Sigulinsky, B. W.
Jones, J. R. Anderson, C. B. Watt, S. Mohammed, R.
E. Marc. Ophthalmology-Sch of Med, University of
Utah/Moran Eye Center, Salt Lake City, UT *CR
1755 — 11:15 Properties of release from rods
revealed by visualizing individual synaptic
vesicles. Minghui Chen1, 2, M. J. Van Hook1,
D. Zenisek3, W. B. Thoreson1, 2. 1Department of
Ophthalmology & Visual Sciences, University of
Nebraska Medical Center, Omaha, NE; 2Department
of Pharmacology & Experimental Neuroscience,
University of Nebraska Medical Center, Omaha,
NE; 3Department of Cellular and Molecular
Physiology, Yale University School of Medicine,
New Haven, CT
1756 — 11:30 Photoreceptor Synaptic
Rbbon Plasticity and Its Impact on the Size
and Frequency of Miniature-like Postsynaptic
Currents in the Hibernating Grund Squirrel
Retina. Wei Li, S. Chen. Unit of Retinal
Neurophysiol, National Eye Institute, NIH,
Bethesda, MD
1757 — 11:45 Calmodulin regulates vesicle
replenishment and shapes kinetics of synaptic
transfer from cones. Matthew J. Van Hook1, W. B.
Thoreson1, 2. 1Ophthalmology & Visual Sciences,
University of Nebraska Medical Center, Omaha,
NE; 2Pharmacology & Experimental Neuroscience,
University of Nebraska Medical Center, Omaha, NE
1758 — 12:00 The kinetic properties of
negative feedback from horizontal cells to cones.
Maarten Kamermans1, R. Vroman1, L. Klaassen1,
T. Sjoerdsma1, R. G. Smith2, M. H. Howlett1.
1
Retinal Signal Processing, Netherlands Institute
for Neuroscience, Amsterdam, Netherlands;
2
Department of Neuroscience, University of
Pennsylvania, Philadelphia, PA
1759 — 12:15 Synaptic interactions in the
outer retina of the mouse. Robin Kemmler, T.
Euler, T. Schubert. Ophthalmic Research, CIN,
Tuebingen, Germany
1760 — 12:30 An interaction between parallel
circuits alters the state of a synapse and the
retinal representation of visual space. Greg
Schwartz, W. Grimes, F. Rieke. Physiology and
Biophysics, University of Washington, Seattle, WA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
141
Monday Papers
11:00 am – 12:45 pm
1742 — 11:30 Assessing the Mosaic of Cone
Photoreceptors Overlying Subretinal Drusenoid
Deposits in vivo Using Adaptive Optics. Sarah
Mrejen1, 2, T. Sato1, 2, R. F. Spaide1, 2. 1vitreous
retina macula consultants of New York, New York,
NY; 2LuEsther T Mertz Retinal Research Center,
Manhattan Eye, Ear and Throat Hospital, New York,
NY *CR
TCC 303
1761 – 1767 – Monday – Papers
TCC 305
Monday, May 06, 2013 11:00 AM-12:45 PM
Nanotechnology and Regenerative Medicine
249 Nanotechnology and Regenerative
Medicine
Monday Papers
11:00 am – 12:45 pm
Moderators: David R. Pepperberg and
Rajiv R. Mohan
1761 — 11:00 Potentiation of bipolar cell
GABAA receptors by a photo-isomerizable
compound. Lan Yue1, 2, M. Pawlowski3, K. S.
Bruzik3, D. R. Pepperberg1, 2. 1Ophthalmology and
Visual Sciences, University of Illinois at Chicago,
Chicago, IL; 2Bioengineering, University of Illinois
at Chicago, Chicago, IL; 3Medicinal Chemistry and
Pharmacognosy, University of Illinois at Chicago,
Chicago, IL *CR
1762 — 11:15 Insulin-like Growth Factor
Binding Protein-like 1 (IGFBPL1) as a Potent
Regulator of Optic Nerve Regeneration.
Chenying Guo1, K. Cho1, K. T. Tchedre1, J. Ma1, C.
Antolik1, D. F. Chen1, 2. 1Ophthalmology, Harvard
Medical School, Schepens Eye Research Institute,
Boston, MA; 2VA Boston Healthcare System,
Boston, MA *CR
1766 — 12:15 Face Detection using the Argus®
II Retinal Prosthesis System. Paulo E. Stanga1, 2,
J. A. Sahel5, 4, S. Mohand-Said4, 5, L. daCruz6, A.
Caspi3, F. Merlini3, R. J. Greenberg3. 1Manchester
Vision Regeneration (MVR) Lab, Manchester
Royal Eye Hospital, Manchester, United Kingdom;
2
Manchester Academic Health Science Centre and
Centre for Ophthalmology and Vision Research,
Institute of Human Development, University
of Manchester, Manchester, United Kingdom;
3
Second Sight Medical Products, Inc, Sylmar, CA;
4
CHNO des Quinze-Vingts, INSERM-DHOS CIC
503, Paris, France; 5Institut de la Vision, CNRS,
UMR_7210, Paris, France; 6Moorfields Eye
Hospital, Moorfields Eye Hospital, London, United
Kingdom *CR, f
1767 — 12:30 Transfer characteristics of
electronic subretinal implants measured by
electrically evoked corneal potentials. Katarina
Stingl1, K. Bartz-Schmidt1, D. Besch1, A. Braun2, F.
Gekeler1, U. Greppmaier2, A. Schatz1, E. Zrenner1.
1
Center for Opthalmology, University of Tuebingen,
Tuebingen, Germany; 2Retina Implant AG,
Reutlingen, Germany *CR, f
1763 — 11:30 Subretinal Implantation of
Gelatin Films with Stem Cells Derived RPE in
Rats. Yuntao Hu1, 3, K. Kuwahara1, P. B. Thomas1,
B. Diniz1, 4, R. Ribeiro1, 5, A. K. Ahuja1, S. T. Hikita2,
L. V. Johnson2, B. B. Thomas1, M. S. Humayun1.
1
Doheny Eye Institute, Keck School of Medicine
of the University of Southern California, Los
Angeles, CA; 2Center for Stem Cell Biology
and Engineering, University of California-Santa
Barbara, Santa Barbara, CA; 3Ophthalmolgy, Peking
University Third Hospital, Beijing, China; 4Retina
Sector, Universidade Federal de Sao Paulo, Sao
Paulo, Belize; 5Hospital Evangelico de Curitiba,
FEMPAR, Curitiba, Belize *CR
1764 — 11:45 RPE for photoreceptor
regeneration in mouse eye. Shu-Zhen Wang,
R. Yan. Ophthalmology, Univ of Alabama at
Birmingham, Birmingham, AL
1765 — 12:00 Conjugation of antibody on
biocompatible nanoparticles for targeted drug
delivery. Jin Zhang1, 2, W. Tse1, W. G. Hodge2.
1
Chemical and Biochemical Engineering, University
of Western Ontario, London, ON, Canada; 2Ivey
Eye Institute, London, ON, Canada
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
142
Monday – Posters – 1768 – 1709
Exhibit Hall A0114-A0159
Monday, May 06, 2013 11:00 AM-12:45 PM
Retinal Cell Biology
250 Oxidative/ER Stress and Autophagy
in RPE and Retina
Moderators: William C. Gordon and
Ryan Thummel
1769 — A0115 Effect of UVB irradiation on
inhibitor of apoptosis proteins(IAPs) in apoptotic
retinal pigment epithelial cell lines. Lin Lu.
Retina, Zhongshan Ophthalmic Center,Sun Yat-Sen
University, Guangzhou, China
1770 — A0116 Testing the effect of RPE barrier
function regulators in vitro and in vivo. Meili
Zhu, Y. Le. Medicine and Harold Hamm Diabetes
Center, University of Oklahoma Health Sciences
Center, Oklahoma City, OK
1771 — A0117 Effect of Cfh on the response
to acute subretinal oxidative stress. xiao chen, B.
Aredo, R. Ufret-Vincenty. UT Southwestern Medical
Center, Dallas, TX
1772 — A0118 Modulating inflammation in
retina through targeting of GPR109A: Novel
implications for therapeutic management of
diabetic retinopathy. Deeksha Gambhir1, R.
Veeranan-Karmegam1, A. M. Tawfik2, S. B. Smith2, 3,
V. Ganapathy1, P. M. Martin1, 3. 1Biochemistry
and Molecular Biology, Georgia Health Sciences
University, Augusta, GA; 2Cellular Biology and
Anatomy, Georgia Health Sciences University,
Augusta, GA; 3Ophthalmology, Georgia Health
Sciences University, Augusta, GA
1773 — A0119 Photoreceptor outer segment
phagocytosis couples lysosome biogenesis to
autophagy in the retinal pigment epithelium. Jin
Xu, K. A. Toops, A. Lakkaraju. Ophthalmology and
Visual Science, UW-Madison, Madison, WI
1774 — A0120 Absence of Neural Cell
Adhesion Molecule (NCAM) influences injured
retinal cell survival. Po-shan Margaret Luke1,
T. L. LeVatte1, D. B. Clarke1, 2. 1Anatomy and
Neurobiology, Dalhousie University, Halifax, NS,
Canada; 2Ophthalmology and Visual Sciences,
Dalhousie University, Halifax, NS, Canada
1776 — A0122 Rapid photoreceptor
degeneration in the area centralis and visual
streak of Rpe65-deficient dogs: morphologic and
histologic characterization. Freya M. Mowat1, 2,
L. M. Occelli1, K. J. Gervais1, M. J. Annear1, J. T.
Bartoe1, A. Georgiadis2, J. W. Bainbridge2, R. R.
Ali2, S. M. Petersen-Jones1. 1Small Animal Clinical
Sciences, Michigan State University, East Lansing,
MI; 2Deparment of Genetics, UCL Institute of
Ophthalmology, London, United Kingdom *CR
1777 — A0123 The Role Of Tlr4 In Retinal
Ganglion Cell Death After Ischemia. Andrea
Rachelle C. Santos, G. Dvoriantchikova, E. P.
Hernandez, D. V. Ivanov. Ophthalmology, Bascom
Palmer Eye Institute, University of Miami, Miami,
FL
1778 — A0124 Catch-up phenomenon in
drusenoid pigment epithelium detachment
and acquired vitelliform lesions in AMD. Rosa
Dolz-Marco, R. Gallego-Pinazo. Ophthalmology,
University and Polytechnic Hospital La Fe,
Valencia, Spain *CR
1779 — A0125 Molecular events for Bax
activation in retinal cell death induced by alltrans-retinal. Osamu Sawada1, 4, A. Maeda1, 2,
S. Matsuyama2, 3, T. Maeda1, 2. 1Ophthalmology,
Case Western Reseve University, Cleveland, OH;
2
Pharmacology, Case western Reserve University,
Cleveland, OH; 3Medicine; Division of Hematology
and Oncology, Case Western Reserve University,
Cleveland, OH; 4Ophthalmology, Shiga University
of Medical Science, Otsu, Japan *CR
1780 — A0126 Adult human RPE has greater
susceptibility to IL17A-induced degeneration
than fetal human RPE. Xi K. Chu1, Y. Wang1, D.
Shen1, A. J. Ogilvy2, R. Li3, S. Jawad1, B. Liu1, M.
S. Abu-Asab2, J. Tuo1, C. Chan1. 1Laboratory of
Immunology, National Eye Institute, Bethesda,
MD; 2Histopathology Core, National Eye Institute,
Bethesda, MD; 3Section on Epithelial and Retinal
Physiology and Disease, National Eye Institute,
Bethesda, MD
1781 — A0127 Evidence for baseline
abnormalities in the retinal vascular network
of Trp1-Cre mice. Aristomenis Thanos, A. Al
Moujahed, L. H. Young, D. Vavvas. Ophthalmology,
Massachusetts Eye & Ear Infirmary, Boston, MA
*CR
1782 — A0128 Extranuclear DNA: a Normal
Phenomenon or an Indication of Pathology?
Alexander J. Ogilvy1, D. Shen2, Y. Wang2, C.
Chan2, 1, M. S. Abu-Asab1. 1Histopathology Core,
National Eye Institute, Bethesda, MD; 2Laboratory
of Immunology, National Eye Institute, Bethesda,
MD
1783 — A0129 Redox Proteomic Identification
of Molecules in Retinal Endothelial Cells
Undergoing Disulfide Reduction as a Result
of Radiation. Megan E. Crowe1, C. Lieven1,
L. A. Levin1, 2. 1Ophthalmology & Visual
Sciences, University of Wisconsin, Madison, WI;
2
Ophthalmology, McGill University, Montreal, QC,
Canada *CR
1784 — A0130 Metabolite profiling of the
neuroprotective phosphine-borane complex PB1.
Christopher Lieven1, L. A. Levin2, 1. 1Ophthalmology
and Visual Sciences, University of Wisconsin,
Madison, WI; 2Ophthalmology, McGill University,
Montreal, QC, Canada *CR
1785 — A0131 Alcohol exposure induces
toxicity in a human RPE model. Francisco J.
Romero, M. Flores-Bellver, L. Bonet-Ponce, N.
Martinez-Gil, J. M. Barcia, S. Johnsen-Soriano, E.
Arnal. Physiol-School of Medicine, Univ Catolica
de Valencia, Valencia, Spain
1786 — A0132 βA3/A1-crystallin is essential
for lysosome-mediated waste clearance in
retinal pigmented epithelial (RPE) cells. Mallika
Valapala1, C. M. Wilson1, 2, I. A. Bhutto1, S. L. Hose1,
S. Greenbaum1, R. Grebe1, J. T. Handa1, L. Dong3,
E. F. Wawrousek3, D. Sinha1. 1Ophthalmology,
Johns Hopkins Univ Sch of Med, Baltimore, MD;
2
University of Pennsylvania School of Medicine,
Philadelphia, PA; 3National Eye Institute, National
Institutes of Health, Bethesda, MD *CR
1787 — A0133 Progesterone Administration
Decreases Glutamate Concentration In The
Retina Of An Animal Model Of Retinitis
Pigmentosa. Violeta Sanchez-vallejo1, S. BenllochNavarro1, R. Álvarez-Nölting1, F. J. Romero2,
M. Miranda1. 1Physiology, Univ CEU Cardenal
Herrera, Valencia, Spain; 2Univ. Católioca de
Valencia San Vicente Martir, Valencia, Spain
1788 — A0134 Retinal Glutathione And
Glutamate Alterations In The Rd10 Mice.
Maria Miranda1, S. Benlloch-Navarro1, V.
Sanchez-vallejo1, M. Flores-Bellver2, J. M. Soria1,
J. J. Araiz3. 1Instituto de Ciencias Biomédicas,
Universidad CEU Cardenal Herrera, Moncada,
Spain; 2Facultad de Medicina, Universidad Católica
de Valencia ‘San Vicente Mártir’, Valencia, Spain;
3
Cirugia, Universidad del País Vasco, Leioa, Spain
1789 — A0135 CCR2-expressing bone marrow
derived cells promote retinal inflammation in a
mouse model of uveitis. Feeling Yu Ting Chen1,
D. Zhou1, T. C. Metzger2, M. Anderson2, N. A.
McNamara1. 1The Francis I. Proctor Foundation
for Research in Ophthalmology, University of
California, San Francisco, San Francisco, CA;
2
Diabetes Center, University of California, San
Francisco, San Francisco, CA
1790 — A0136 High Throughput siRNA Screen
to Identify Targets of RPE Cells Protection from
7-Ketocholesterol Induced Oxidative Damage. JiYe Wei, J. E. Chatterton, C. Romano, K. L. Rhoades.
Ophthalmology, Novartis Institutes for Biomedical
Research, Alcon Research Ltd., Fort Worth, TX
*CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
143
Monday Posters
11:00 am – 12:45 pm
1768 — A0114 Photobiomodulation by 670nm
light protects against oxidative stress in multiple
organs in a rodent model of diabetes mellitus.
Johnny Tang1, Y. Du2, J. Lim6, S. Gopalakrishnan5,
J. T. Eells3, D. Henshel5, J. B. Watkins7, T. S.
Kern2, 4. 1Department of Ophthalmology, The
University of Kansas Medical Center, Kansas City,
KS; 2Department of Pharmacology, Case Western
Reserve University, Cleveland, OH; 3Department
of Biomedical Sciences, University of WisconsinMilwaukee, Milwaukee, WI; 4Research Services,
Louis Stokes VA Medical Center, Cleveland, OH;
5
Department of Public and Environmental Affairs,
Indiana University, Bloomington, IN; 6National
Institutes of Health, Bethesda, MD; 7School of
Pharmacology and Toxicology, Indiana University,
Bloomington, IN *CR
1775 — A0121 P23H-Light Induced Retinal
Degeneration occurs via cell death with
autophagy in a Xenopus laevis Model of
Retinitis Pigmentosa. Tami P. Bogea, B. M. Tam,
O. L. Moritz. Ophthalmology & Visual Sciences,
University of British Columbia, Vancouver, BC,
Canada
1791 – 1815 – Monday – Posters
1791 — A0137 Neuroprotectin D1 (NPD1)
Reverses 15 Lipoxygenase-1 Inhibition of
Oxidative Preconditioning in RPE cells.
Eric J. Knott1, W. C. Gordon1, 2, N. G. Bazan1, 2.
1
Neuroscience Center, Louisiana State Univ Hlth
Sci Ctr, New Orleans, LA; 2Ophthalmology,
Louisiana State Univ Hlth Sci Ctr, New Orleans, LA
Monday Posters
11:00 am – 12:45 pm
1792 — A0138 Neuroprotectin D1 Mimics
Preconditioning by Inducing RPE Cell Survival
Against Subsequent Oxidative Stress. William C.
Gordon, E. J. Knott, N. G. Bazan. Ophthalmology
& Neuroscience Center, LSU Health Sciences
Center, New Orleans, LA
1793 — A0139 DHA restores VEGF via Nrf2
protection pathway inhibiting oxidative damage
in RPE at high glucose levels. Siv JohnsenSoriano1, E. Arnal1, M. Flores-Bellver2, L. BonetPonce2, F. Romero1, 2. 1Fundación Oftalmológica del
Mediterráneo (FOM), Valencia, Spain; 2Facultad
de Medicina, Universidad Católica de Valencia,
Valencia, Spain
1794 — A0140 Docosahexaenoic Acid Bolsters
Mild Oxidative Stress Preconditioning in Retinal
Pigment Epithelial Cells. Nicolas G. Bazan, W. C.
Gordon, E. J. Knott. Ophthal & Neuroscience, LSU
Health Sciences Center, New Orleans, LA
1795 — A0141 Physicochemical evidence for
oxidative modifications of human RPE melanin
with aging and of bovine RPE melanin with in
vitro photoaging. Tadeusz J. Sarna1, A. K. Pilat1,
A. Zadlo1, S. Ito2, K. Wakamatsu2, G. Szewczyk1,
A. Kittell3, T. G. Camenisch3, J. M. Burke4, C.
Skumatz4. 1Biophysics, Jagiellonian University,
Krakow, Poland; 2Chemistry, Fujita Heath
University School of Health Sciences, Toyoake,
Japan; 3Biophysics, Medical College of Wisconsin,
Milwaukee, WI; 4Ophthalmology, Medical College
of Wisconsin, Milwaukee, WI
1796 — A0142 PGC-1 isoforms regulate
photoreceptor response to photo-oxidative
stress: relevance to retinal degenerative
diseases. Jared Iacovelli1, 4, Z. Arany2, 3, M. SaintGeniez1, 4. 1The Schepens Eye Research Institute,
Massachusetts Eye and Ear Infirmary, Boston, MA;
2
CardioVascular Institute, Beth Israel Deaconess
Medical Center, Boston, MA; 3Medicine, Harvard
Medical School, Boston, MA; 4Ophthalmology,
Harvard Medical School, Boston, MA
1797 — A0143 Protective effect of fenofibrate
on oxidative stress induced retinal neuronal
cell damage. Ying-Jung Hsu1, S. Cho2, C. Yang3.
1
Graduate Institute of Clinical Medicine, National
Taiwan University, Taipei, Taiwan; 2College of
Medicine, National Taiwan University, Taipei
city, Taiwan; 3Ophthalmology, National Taiwan
University Hospital, Taipei city, Taiwan
1798 — A0144 Overexpression of OASIS/
CREB3L1 in photoreceptor of zebrafish
Induces Photoreceptor Cell Death without
Classical Endoplasmic Reticulum Stress
Response. Yoshihito Oura, M. Tsujikawa, K.
Nishida. Ophthalmology, Osaka University, Suita,
Afghanistan *CR
1799 — A0145 Catechins attenuate sodium
iodate-induced retinal degeneration. Yaping
Yang1, Y. Qin1, Y. Yip1, K. Chu1, 2, K. Chan1, C.
Pang1, S. Chan3. 1Department of Ophthalmology
& Visual Sciences, The Chinese University of
Hong Kong, Hong Kong, Hong Kong; 2Department
of Obstetrics & Gynaecology, The Chinese
University of Hong Kong, Hong Kong, Hong Kong;
3
Department of School of Biomedical Sciences, The
Chinese University of Hong Kong, Hong Kong,
Hong Kong
1800 — A0146 Cigarette Smoke (CS) and Nrf2
Deficiency Induce Mitochondrial Dysfunction in
Retinal Pigment Epithelial (RPE) Cells. Marisol
D. Cano, B. Barnett, L. Wang, S. E. Dike, J. T.
Handa. Wilmer Eye Institute/Ophthalmology, Johns
Hopkins University, Baltimore, MD *CR
1801 — A0147 Oxidative stress affects tight
junction expression in Human retinal pigment
epithelium. Junko Hirata, J. Ko, H. Mochizuki, K.
Funaishi, K. Yamane, Y. Kiuchi. Ophthalmology,
Hiroshima university, Hiroshima, Japan
1802 — A0148 Mechanism of RPE cell death
following activation of the NLRP3 inflammasome
by lipofuscin photoreactivity. Carolina
Brandstetter, L. K. Mohr, F. G. Holz, T. U. Krohne.
Department of Ophthalmology, University of Bonn,
Bonn, Germany *CR
1803 — A0149 Activation of Rap1 prevents
tumor necrosis factor alpha-induced ROS
generation in RPE. Haibo Wang1, M. McCloskey1,
E. S. Wittchen2, M. Hartnett1. 1John A Moran Eye
Ctr, Ophthalmology, University of Utah, Salt Lake
City, UT; 2Department of Cell and Developmental
Biology, Univeristy of North Carolina at Chapel
Hill, Chapel Hill, NC *CR
1804 — A0150 Calpain Inhibition Following
Retinal Detachment: A Way to Prolong
Autophagy and Delay Apoptosis. Nicholas D.
Chinskey, Q. D. Zheng, D. N. Zacks. Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI *CR
1805 — A0151 Protective effect of TGF-b1 in
RPE cells upon oxidative stress as a model for
oxidative damage during dry AMD. Zeev Dvashi,
A. Pollack. Ophthalmology, Kaplan Medical Center,
Rehovot, Israel
1806 — A0152 In the retinal mitochondrial
oxidative stress NLRC4 inflammasome silencing
attenuates photoreceptor pyroptosis. Narsing A.
Rao, S. Saraswathy. Ophthalmology, Doheny Eye
Institute, Los Angeles, CA
1807 — A0153 Aberrant Protein Trafficking
Underlies Vision Defects in Syndromic Albinism.
Ryan Thummel1, X. Luo1, A. Dombkowski2,
J. Granneman3. 1Anatomy/Cell Biology &
Ophthalmolgy, Wayne State University School
of Medicine, Detroit, MI; 2Pediatrics, Wayne
State University School of Medicine, Detroit,
MI; 3Psychiatry and Behavioral Neuroscience
and Pathology, Wayne State University School of
Medicine, Detroit, MI
1808 — A0154 ER stress involvement in
photoreceptor death in tubby mice. Xue Cai1,
J. F. McGinnis1, 2. 1Ophthalmology, University of
Oklahoma Health Sciences Center, Oklahoma CIty,
OK; 2Cell Biology, University of Oklahoma Health
Sciences Center, Oklahoma CIty, OK
1809 — A0155 Temperature-dependent
response of retinal pigment epithelial cells to
laser irradiation. Ralf Brinkmann1, 2, H. Iwami3,
J. Pruessner1, V. Danicke2, Y. Miura1. 1Institute
of Biomedical Optics, University of Luebeck,
Luebeck, Germany; 2Medical Laser Center
Luebeck, Luebeck, Germany; 3Department of
Ophthalmology, Osaka City University, Osaka,
Japan *CR
1810 — A0156 Receptor-Interacting Protein
Kinases and the NLRP3 Inflammasome Mediate
Tamoxifen Toxicity of the Retinal Pigment
Epithelium. Leo A. Kim1, 2, D. Amarnani1, 2,
W. A. Tseng1, 2, D. Vavvas1, P. A. D’Amore1, 2.
1
Ophthalmology, Massachusetts Eye and Ear
Infirmary, Harvard Medical School, Boston, MA;
2
Ophthalmology, Schepens Eye Research Institute,
Boston, MA *CR
1811 — A0157 7-Ketocholesterol induces
cytokines through NF-κB activation and CHOP
in ARPE-19 cells. Jiahn-Dar Huang, J. W. Lee,
I. R. Rodriguez. LRCMB, National Eye Institute,
Bethesda, MD
1812 — A0158 Ethambutol-induced autophagy
deregulation and cytotoxic effects in retinal
ganglion cells. Shun-Ping Huang1, 2, S. Lin1, R.
Tsai1. 1Ophthalmology, Tzu Chi General Hospital,
Hualien, Taiwan; 2Molecular Biology and Human
Genetics, Tzu Chi University, Hualien, Taiwan
1813 — A0159 Circadian rhythm of basal
autophagy and its regulation in the RPE.
Jingyu Yao1, L. Jia1, S. Shelby1, A. Ganios1, D.
A. Thompson1, 2, D. N. Zacks1. 1Department of
Ophthalmology, Univ Michigan-Kellogg Eye
Ctr, Ann Arbor, MI; 2Department of Biological
Chemistry, Univ Michigan-Kellogg Eye Ctr, Ann
Arbor, MI *CR
Exhibit Hall A0160-A0195
Monday, May 06, 2013 11:00 AM-12:45 PM
Lens / Clinical/Epidemiologic Research
251 Cataract Surgery II
Moderator: Raffael Liegl
1814 — A0160 Does Music Influence Surgical
Time in Routine Cataract Surgery? Sajjad Abbas.
Ophthalmology, Luton & Dunstable Hospital,
London, United Kingdom
1815 — A0161 Comparison of Tissue
Temperature in Sleeveless Microincision 1.1
mm and Conventional Coaxial Mini-Incision
2.4 mm Phacoemulsification. Avner Belkin1, A.
Abulafia1, 2, S. Ofir1, A. Michaeli3, 2, E. I. Assia1, 2.
1
Ophthalmology, Meir Medical Center, Kfar Saba,
Israel; 2Ein Tal Eye Center, Tel Aviv, Israel; 3Tel
Aviv Sourasky Medical Center, Tel Aviv, Israel
*CR, f
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
144
Monday – Posters – 1816 – 1841
1816 — A0162 A Case of Lens Subluxation
Associated with Congenital Cytomegalovirus
Infection. Risa Yamazaki1, 2, T. Tachikawa1, 3, T.
Mita1, D. Yuzurihara1, O. Katsumi1, 4, T. Noda2,
3 1
. Ophthalmology, Tokyo Metropolitan Ohtsuka
Hospital, Tokyo, Japan; 2Ophthalmology,
National Tokyo Medical Center, Tokyo, Japan;
3
Ophthalmology, Tokyo Women’s Medical
University, Medical Center East, Tokyo, Japan;
4
Ophthalmology, Nishikasai Inoue Pediatric Eye
Clinic, Tokyo, Japan
1817 — A0163 From Accommodation
Restoration to the Antioxidant Lens Sink:
Theoretical Basis for Lenticular Refractive
Surgery. Raymond I. Myers1, S. R. Lakamp2,
1 1
. College of Optometry, Univ of Missouri-St
Louis, Collinsville, IL; 2College of Optometry,
Northeastern State University, Tahlequah, OK *CR
1819 — A0165 Increasing Incidence of
Cataract Surgery: A Population-based Study. Jay
C. Erie, H. Gollogly, D. Hodge. Ophthalmology,
Mayo Clinic, Rochester, MN
1820 — A0166 A Comparison of Biplanar
Cataract Incision Postoperative Architecture
Involving Malyugin Ring Insertion as Performed
by a Resident Surgeon. Solomon W. Ross, B.
Markowitz. Ophthalmology, University of South
Carolina, Columbia, SC
1821 — A0167 Validation of a Virtual Cataract
Surgery Simulator for Simulation-Based
Medical Education. Shameema Sikder1, A. M.
Alfawaz2, 5, J. Song1, 2, P. Banerjee3, C. J. Luciano3,
J. Luo3, P. Kania4. 1Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD; 2King Khaled
Eye Speciality Hospital, Riyadh, Saudi Arabia;
3
University of Illinois, Chicago, Chicago, IL;
4
Immersive Touch, Chicago, IL; 5Ophthalmology,
King Saud University, Riyadh, Saudi Arabia *CR
1822 — A0168 Exploration of a Circularly
Polarized Femtosecond Laser Beam for Laser
Cataract Application. Anthony Dennison, M. A.
Campos, M. Levin, H. Fu. Abbott Medical Optics,
Santa Ana, CA *CR
1823 — A0169 Effect of numerical aperture of
a femtosecond laser system on the required pulse
energy for capsulotomy and lens fragmentation.
Michael A. Campos, A. Dennison, H. Fu. R&D Advanced Development, Abbott Medical Optics,
Santa Ana, CA *CR
1824 — A0170 The effect of cataract on
circadian phototentrainment. Adam E.
Brondsted1, 4, B. Haargaard1, B. A. Sander1, H.
Lund-Andersen1, 4, P. Jennum3, 4, S. Gammeltoft2,
L. Kessel1, 4. 1Dept. of Ophthalmology, Glostrup
Hospital, Glostrup, Denmark; 2Dept. for Clinical
Biochemistry, Glostrup Hospital, Glostrup, Denmark;
3
Danish Center for Sleep Medicine, Dept. for Clinical
Neurophysiology, Glostrup Hospital, Glostrup,
Denmark; 4Faculty of Health Sciences, University of
Copenhagen, Copenhagen, Denmark f
1832 — A0178 Cataract Surgery with
Intraocular Lens Implantation in Patients with
Vogt Koyanagi Harada Syndrome. Erika Miolet
Hurtado Jallaza, B. A. Schlaen, C. A. Couto, M.
Frick, M. Lopez. Ophthalmology, University of
Buenos Aires, Buenos Aires, Argentina
1826 — A0172 Impact of intra-operative floppy
iris and use of pupillary expansion devices on
intra-operative complication rates in cataract
surgery: results of the Ophthalmic Surgical
Outcomes Data Project. David E. Vollman1, 2,
A. Chomsky4, 3, E. Baze6, 5, M. K. Daly7, 8, M. G.
Lawrence9. 1Ophthalmology and Visual Sceinces,
Washington University School of Medicine, St.
Louis, MO; 2St. Louis VA Medical Center, St.
Louis, MO; 3Vanderbilt Eye Institute, Vanderbilt
University School of Medicine, Nashville, TN;
4
VA Tennessee Valley Healthcare System Center,
Nashville, TN; 5Michael E. DeBakey VA Medical
Center, Houston, TX; 6Cullen Eye Institute,
Baylor College of Medicine, Houston, TX; 7VA
Boston Healthcare System, Boston, MA; 8Boston
University School of Medicine, Boston, MA; 9VA/
DoD Vision Center of Excellence, Washington
D.C., DC
1833 — A0179 Intraoperative Management of
Crystalens Intraocular Lens. Mojgan Hassanlou,
D. K. Dhaliwal. Ophthalmology, University of
Pittsburgh Medical Center, Pittsburgh, PA
1827 — A0173 Analysis of corneal incisional
structure in different incision size with or
without stromal hydration in cataract surgery
by using anterior segment optical coherence
tomography. Jonghyun Lee, J. Bang, D. Lee.
Department of Ophthalmology, Inje University,
Ilsan Paik Hospital, Goyang, Gyung-gi-do,
Republic of Korea
1828 — A0174 Wavefront Analysis Comparison
Of Aspheric Versus Spherical Intraocular
Lens Implantation In Cataract Surgery - A
Meta-Analysis. Alexander K. Schuster1, 2, J.
Tesarz3, U. Vossmerbaeumer4, 1. 1Mannheim
Institute of Public Health, Social and Preventive
Medicine, Medical Faculty Mannheim, Heidelberg
University, Mannheim, Germany; 2Department
of Ophthalmology, Medical Faculty Mannheim,
Heidelberg University, Mannheim, Germany;
3
Department of General Internal Medicine and
Psychosomatics, Medical Hospital, University of
Heidelberg, Heidelberg, Germany; 4Department
of Ophthalmology, University of Mainz, Mainz,
Germany
1829 — A0175 Rotational stability of a
hydrophobic-acrylic aspheric toric intraocular
lens. Sanjeev Kasthurirangan1, D. R. Nixon2,
L. Feuchter1, P. Smith1. 1Clinical R&D, Abbott
Medical Optics, Milpitas, CA; 2North Ontario
School of Medicine, Sudbury, ON, Canada *CR, f
1830 — A0176 Refractive surgical outcomes of
cataract surgeons in training. Gokul Kumar, A. Y.
Lee, C. S. Lee. Ophthalmology, Washington Univ in
St Louis, Saint Louis, MO *CR
1831 — A0177 The effect of a second 2.4mm
keratome incision on reducing post-operative
astigmatism in cataract surgery. Riley Hall, G.
Singh, M. Agha, N. K. Wade. University of British
Columbia, Vancouver, BC, Canada
1834 — A0180 Intraocular lens power
prediction in eyes with prior radial keratotomy
using Fourier-domain optical coherence
tomography. Emily Waisbren1, L. Wang1, M. Tang2,
D. D. Koch1. 1Cullen Eye Institute, Baylor College
of Medicine, Houston, TX; 2Casey Eye Institute,
Oregon Health and Science University, Portland,
OR *CR
1835 — A0181 Comparison of cumulative
dissipated energy, total phacoemulsification time,
and visual acuity in the early post operative
period following uncomplicated cataract
extraction by resident surgeons with and
without the use of intracameral preservative
free epinephrine. Benjamin A. Katz, B. Markowitz.
Ophthalmology, University of South Carolina,
Columbia, SC
1836 — A0182 Phacoemulsification Parameters
and Measures of Corneal Edema. Melissa M.
Wong1, A. Shukla2, W. M. Munir1. 1Ophthalmology,
Boston Univ School of Med, Boston, MA;
2
Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA
1837 — A0183 Comparison of surgical
results between intrascleral posterior chamber
intraocular lens (PC-IOL) fixation and
transscleral suturing of PC-IOL in eyes without
capsular support. Shunji Kusaka1, S. Komoto1, A.
Fujii1, K. Aomatsu1, E. Koike1, K. Tachibana1, S.
Higaki1, Y. Shimomura2, 1. 1Ophthalmology, Sakai
Hosp Kinki Univ Faculty of Med, Sakai, Japan;
2
Ophthalmology, Kinki University Faculty of
Medicine, Sayama, Japan
1838 — A0184 Initial Resident Experience
Performing Cataract Surgery with and without
Femtosecond Laser. Adam L. Prickett, M. S.
Cortina, J. H. Hou, J. De la Cruz. Ophthalmology
and Visual Sciences, University of Illinois Eye and
Ear Infirmary, Chicago, IL *CR
1839 — A0185 Does case order affect cataract
surgery complication rates and case time? Parisa
Taravati, D. Gupta, L. Ding. Ophthalmology, Univ
of Washington, Med Center, Seattle, WA
1840 — A0186 Ophthalmic Surgery Simulator
Training Improves Resident Performance of
Capsulorhexes in the Operating Room. David C.
Reed, D. R. Goldman, C. A. McCannel. Jules Stein
Eye Institute, UCLA, Los Angeles, CA *CR
1841 — A0187 Model of Plasma Characteristics
across the Anterior Lens and Aqueous Boundary.
Richard T. Olmstead. R & D, LensAR, Orlando,
FL *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
145
Monday Posters
11:00 am – 12:45 pm
1818 — A0164 Evaluation of femtosecond
laser-assisted clear cornea cataract surgery in
lens exfoliation syndrome (LES). Anam Qureshi1,
A. Kanellopoulos1, 2. 1Ophthalmology, New York
University, New York, NY; 2LaserVision.gr
Institute, Athens, Greece *CR
1825 — A0171 Anesthesia Choice and
Pain Control during Cataract Surgery. Yuna
Rapoport1, 2, A. Chomsky1, 2, L. L. Wayman1, 2.
1
Ophthalmology, Veterans Affairs Tennessee Valley
Healthcare System, Nashville, TN; 2Vanderbilt Eye
Institute, Vanderbilt University, Nashville, TN
1842 – 1865 – Monday – Posters
1842 — A0188 A Possible Root Cause for
Incomplete Cornea Incision in a Femtosecond
Laser Cataract Surgery. Hong Fu. Abbott Medical
Optics, Santa Ana, CA *CR
Monday Posters
11:00 am – 12:45 pm
1843 — A0189 Combined phacoemulsification,
primary IOL implantation and pars plana
vitrectomy in children with uveitis. Madeleine
Zetterberg1, 2, S. Pålsson1, 2, M. A. Gronlund1, 3,
A. Nyström1, 3. 1Institute of Neuroscience
and Physiology, University of Gothenburg,
Mölndal, Sweden; 2Ophthalmology, Sahlgrenska
University Hospital, Mölndal, Sweden; 3Pediatric
Ophthalmology, Sahlgrenska university hospital,
Göteborg, Sweden
1844 — A0190 Forward Light Scatter,
Modulation Transfer Function and Image
Quality Measurements for AcrySof
Natural Intraocular Lenses. Kamal Das1, J.
Schwiegerling2, M. Karakelle1, J. Stover3, M. Ong1.
1
Alcon Laboratories, Inc, Fort Worth, TX; 2The
University of Arizona, Tucson, AZ; 3The Scatter
Works, Inc., Tucson, AZ *CR
1845 — A0191 Posterior iris-claw aphakic
intraocular lens implantation in children.
Johannes Gonnermann, N. Torun, M. Klamann, A.
B. Maier, P. Rieck, E. Bertelmann. Ophthalmology,
University Medicine Charité, Berlin, Germany
1846 — A0192 Performance of a new preloaded
insertion system for a 1-piece hydrophobicacrylic, aspheric intraocular lens. Steven
Anderson1, L. Feuchter1, R. Pohl1, M. Amon3, 1,
O. Findl2, 1, G. Sauder4, 1. 1Abbott Medical Optics
Inc., Santa Ana, CA; 2Ophthalmology, VIROS
- A Karl Landsteiner Institute, Vienna, Austria;
3
Ophthalmology, Krankenhaus der Barmherzigen
Brüder Wien, Vienna, Austria; 4Ophthalmology,
Charlottenklinik für Augenheilkunde, Stuttgart,
Germany *CR
1847 — A0193 Intraoperative and
perioperative OCT findings of cataract surgery.
Richard Gans, J. P. Ehlers, W. J. Dupps, G. M.
Smith, P. K. Kaiser, S. K. Srivastava. Cole Eye
Institute, Cleveland Clinic Foundation, Cleveland,
OH *CR
1848 — A0194 Refractive Outcomes of Toric
Intraocular Lens Implantation for Correction
of Astigmatism During Cataract Surgery.
Naveen K. Rao1, 2, A. Althawabi1, K. L. Tawse2, S.
H. Soukiasian1, 2. 1Ophthalmology, Lahey Clinic,
Burlington, MA; 2Ophthalmology, Tufts Medical
Center, Boston, MA *CR
1849 — A0195 Comparison of Biplanar
Cataract Incision Postoperative Architecture
With and Without Wound Suture as Performed
by a Resident Surgeon. Michelle A. Overturf, S. W.
Ross, B. Markowitz. Ophthalmology, USC School
of Medicine/Palmetto Health, Columbia, SC
Exhibit Hall B0104-B0157
Monday, May 06, 2013 11:00 AM-12:45 PM
Glaucoma
252 Lasers; Structure and Function I
Moderator: Carlo Enrico Traverso
1850 — B0104 Narrower Angles Are
Associated with Greater Angle Opening After
Laser Peripheral Iridotomy. Roland Y. Lee1, T.
Kasuga1, 2, Q. N. Cui1, S. C. Lin1. 1Ophthalmology,
University of California, San Francisco, San
Francisco, CA; 2Ophthalmology, Juntendo
University School of Medicine, Tokyo, Japan
1851 — B0105 Comparison of fluctuations of
intraocular pressure before and after selective
laser trabeculoplasty in normal tension
glaucoma. Naoki Tojo, K. Mitarai, M. Oka, A.
Miyakoshi, A. Hayashi. Dept of Ophthal and Visual
Science, Toyama University Sch of Med, Toyama,
Japan
1852 — B0106 Diode Cyclophotocoagulation
for the Treatment of Refractory Childhood
Glaucomas. Lekha Ravindraraj, S. S. Kommana, R.
D. Fechtner, A. S. Khouri. Ophthalmology & Visual
Science, University of Medicine & Dentistry of NJNJ Medical School, Newark, NJ
1853 — B0107 Change in Intraocular Pressure
and Angle of Eyes with Primary Angle Closure
Suspects One Year after Laser Peripheral
Iridotomy. Dapeng Mou. Beijing Tongren hospital,
Beijing, China f
1854 — B0108 The influence of treatment
settings for SLT and ALT in the management of
open angle glaucoma (OAG): a systematic review
and meta-analysis. Sourabh Arora, K. F. Damji, E.
Weis. University of Alberta, Edmonton, AB, Canada
1855 — B0109 Intraocular Pressure Spikes
following Sequential Laser Peripheral Iridotomy
for Angle Closure. Jamie Ng1, 2, T. Lee1, M.
E. Nongpiur1, 3, W. Tan2, T. Aung1, 2, S. Perera1.
1
Singapore National Eye Centre and Singapore Eye
Research Institute, Singapore, Singapore; 2National
University Health Systems, Singapore, Singapore;
3
Yong Loo Lin School of Medicine, National
University of Singapore, Singapore, Singapore *CR
1856 — B0110 Predictors of Short-Term
Intraocular Pressure Response to Selective
Laser Trabeculoplasty in Afro-Caribbeans with
Glaucoma. Tony Realini. Ophthalmology, WVU
Eye Institute, Morgantown, WV *CR
1857 — B0111 Longitudinal evaluation of
selective laser trabeculoplasty repeatability in
eyes with pseudoexfoliation glaucoma. Ernesto
D. Golez1, M. A. Latina2, 1. 1Ophthalmology,
Massachusetts Eye and Ear Infirmary, Reading,
MA; 2Tufts University School of Medicine, Boston,
MA *CR
1858 — B0112 Predictors of Failure with
Transscleral Diode Laser Cyclophotocoagulation
in the Treatment of Refractory Glaucoma.
Samantha Dewundara, B. A. Hughes, R. Momi,
J. Tannir, C. Kim. Department of Ophthalmology,
Kresge Eye Institute, Detroit, MI
1859 — B0113 The Relationships between
Immediate and Short-term Intra-ocular Pressure
(IOP) Following Selective Laser Trabeculoplasty
(SLT), Trabecular Meshwork Pigmentation
(TMP), and Laser Power Used. Yotam Weiner1,
A. Weiner2. 1University of Michigan, Ann-Arbor,
MI; 2Ophthalmic Consultants of the Capital Region,
Albany, NY
1860 — B0114 Aqueous production reduction
and aqueous outflow increase in rabbit eyes
after ultrasonic cyclocoagulation. Aurelie Begle1,
F. Aptel2, C. Lafon3, J. Chapelon3, F. Romano1.
1
EYETECHCARE, Rillieux la Pape, France;
2
CHU de Grenoble - Hôpital A. Michallon- Service
d’ophtalmologie, Grenoble, France; 3research,
U1032 - LabTAU- INSERM, lyon, France *CR
1861 — B0115 Comparison of argon
laser trabeculoplasty and selective laser
trabeculoplasty: a meta-analysis. Audrey M.
Paulo1, L. H. Razafindrabe2, M. Fredette1, 2.
1
Department of Ophthalmology, Faculty of
Medicine, Université Laval, Quebec, QC, Canada;
2
CUO (Centre universitaire d’ophtalmologie) /
CEVQ (Centre d’excellence sur le vieillisement de
Quebec), Centre de recherche du CHU de Quebec,
Quebec, QC, Canada
1862 — B0116 Selective Laser Trabeculoplasty
in the Treatment of Glaucoma in Phakic Versus
Pseudophakic Patients. Neil Kalbag, S. Patel, A.
S. Khouri, T. L. Berezina, R. D. Fechtner, A. Cohen.
The Institute of Ophthalmology and Visual Science,
New Jersey Medical School, Newark, NJ
1863 — B0117 Trans-scleral Selective Laser
Trabeculoplasty (SLT) Without a Gonioscopy
Lens. Michael Belkin1, N. Geffen2, S. Ofir2, A.
Kaplan Messas3, Y. Barkana4, A. Belkin2, E. I.
Assia2. 1Goldschleger Eye Research Institute,
Tel-Aviv University, Tel-Hashomer, Israel;
2
Ophthalmology, Meir Medical Center, Kfar Saba,
Israel; 3Ophthalmology, Ein Tal Eye Hospital, Tel
Aviv, Israel; 4Ophthalmology, Assaf Harofe Medical
Center, Tzrifin, Israel *CR, f
1864 — B0118 Resident-Performed Selective
Laser Trabeculoplasty in Open Angle Glaucoma
Patients. Eugene Lowry1, D. Greninger4, 1, T.
Porco1, 2, A. Naseri1, 3, R. L. Stamper1, Y. Han1,
3 1
. Ophthalmology, University of California San
Francisco, San Francisco, CA; 2Francis I. Proctor
Foundation, University of California San Francisco,
San Francisco, CA; 3Ophthalmology, San Francisco
Veterans Administration Medical Center, San
Francisco, CA; 4Ophthalmology, Oregon Health and
Science University, Oregon, OR *CR
1865 — B0119 The effect of Selective Laser
Trabeculoplasty on IOP changes in the
contralateral eye over a two-year followup. Sonia
Rana, J. Tannir, B. A. Hughes. Kresge Eye Insitute,
Detroit, MI
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
146
Monday – Posters – 1866 – 1886
1866 — B0120 Assessment of the Long-Term
Outcome of Selective Laser Trabeculoplasty
(SLT) in Treatment of Different Glaucoma Types
in Patients Receiving Maximum Medicinal
Treatment. Eman Elhawy, C. Zangalli, D. M.
Shapiro, L. Gupta, M. Hsieh, A. Kasprenski, L.
Katz, G. L. Spaeth. Ophthalmology, Wills Eye
Institute, Philadelphia, PA *CR
1867 — B0121 Patterned Laser
Trabeculoplasty with PASCAL streamline
577. Miho Nozaki, S. Hirahara, Y. Ogura.
Ophthalmology, Nagoya City Univ Med Sch,
Nagoya, Japan
1868 — B0122 Comparison of Selective Laser
Trabeculoplasty Outcomes Between Physiciansin-Training and Attending Physicians. Wanda Hu,
S. K. Law, J. A. Giaconi. Jules Stein Eye Institute,
Los Angeles, CA *CR
1870 — B0124 Laser trabeculoplasty in
primates: a morphometric analysis. Tina
Damarjian1, Y. Sun1, V. Gattone1, 2. 1Indiana
University, Indianapolis, IN; 2Indiana University,
Indianapolis, IN
1871 — B0125 Long Term Effectiveness and
Complications associated with LPI in Treatment
of Acute Angle Closure. Alicia Menezes, S. B.
Shah, E. Elhawy, B. M. Faria, T. Chia, L. Lu, L.
Katz. Wills Eye Institute, Philadelphia, PA *CR
1872 — B0126 Efficacy of Repeat Selective
Laser Trabeculoplasty in African American
Patients. Mamta Shah, B. Eliassi-Rad. Department
of Ophthalmology, Boston Univ School of Med,
Boston, MA
1873 — B0127 Effect of Pre-operative
Medications on Selective Laser Trabeculoplasty
Outcomes. Babak Eliassi-Rad, M. Shah.
Ophthalmology, Boston University, Boston, MA
1874 — B0128 Plateau Iris among American
Caucasians, American Chinese, and Mainland
Chinese. Yingjie Li1, 2, Y. Wang1, 3, M. Qiu1, D.
Wang1, 4, M. He4, S. C. Lin1. 1Ophthalmology,
University of California San Francisco, San
Francisco, CA; 2Ophthalmology, The Third
Affiliated Hospital of Nanchang University,
Nanchang, China; 3Duke University School
of Medicine, Durham, NC; 4Ophthalmology,
Zhongshan Ophthalmic Center, Sun Yat-sen
University, Guangzhou, China
1876 — B0130 Corneal sensitivity and
morphology of the corneal subbasal nerve
plexus in primary congenital glaucoma.
Zisis Gatzioufas1, 2, F. Hafezi1, B. Seitz2. 1Dpt.
of Ophthalmology, University Hospitals of
Geneva HUG, Geneva, Switzerland; 2Dpt. of
Ophthalmology, Saarland University Medical
Center UKS, Homburg/Saar, Germany *CR
1877 — B0131 Structural and Functional
Changes after lntraocular Pressure Reduction
in Patients with Glaucoma. Michael Waisbourd,
J. Molineaux, T. Myeni, G. L. Spaeth, L. Katz.
Glaucoma Service, Wills Eye Institute, Philadelphia,
PA *CR
1878 — B0132 Classification of Retinal
Ganglion Cell Defects Seen on FrequencyDomain OCT in the Macula of Patients with
Glaucoma. Anastasia Slobodnick1, 2, A. S. Raza1, 3,
C. De Moraes2, 4, C. C. Teng2, 5, R. Ritch2, 5, D. C.
Hood2, 6. 1Psychology, Columbia University, New
York, NY; 2Einhorn Clinical Research Center,
New York Eye and Ear Infirmary, New York,
NY; 3Neurobiology and Behavior, Columbia
University, New York, NY; 4Ophthalmology,
New York University School of Medicine, New
York, NY; 5Ophthalmology, New York Medical
College, Valhalla, NY; 6Ophthalmology, Columbia
University, New York, NY *CR
1879 — B0133 The investigation of correlation
between subfoveal choroidal thickness and
sensitivity of visual field in highly myopic
glaucoma with peripapillary atrophy optic disc.
Kazunori Tamaki1, I. Kimura1, 2, Y. Imamura3,
Y. Nakazawa1, S. Watanabe1, A. Murakami4, N.
Ebihara1. 1Department of Ophthalmology, Juntendo
University Urayasu Hospital, Urayasu City, Japan;
2
National Institute of Sensory Organs, Tokyo
Medical Center, Tokyo, Japan; 3Department of
Ophthalmology, Teikyo University Mizonokuchi
Hospital, Kawasaki City, Japan; 4Department of
Ophthalmology, Juntendo University School of
Medicine, Tokyo, Japan *CR
1880 — B0134 Structure-Function Relationship
between Spectral Domain Optical Coherence
Tomography, Heidelberg Retina Tomograph
and Flicker Defined Form Perimetry in Patients
with Ocular Hypertension and Preperimetric
Glaucoma. Ermengarda Marziani1, L. de Polo1, 2,
E. Collaku1, E. Weiszberger1, A. Acquistapace1,
A. Giani1, M. Blini1, G. Staurenghi1. 1Eye Clinic
Department of Biomedical and Clinical Science
“Luigi Sacco”, Luigi Sacco Hospital, Milan, Italy;
2
COB, Centro Oculistico Bergamasco, Bergamo,
Italy *CR
1881 — B0135 Nailfold Hemorrhages and
Primary Open-Angle Glaucoma: More than
What Meets the Eye. Kevin Skuran1, R. McCarty1,
A. Grybauskas1, P. Kuprys1, J. R. Samples3, P. A.
Knepper1, 2. 1Ophthalmology and Visual Sciences,
University of Illinois at Chicago, Chicago, IL;
2
Ophthalmology, Northwesten University, Chicago,
IL; 3Specialty Eye Care, Denver, IL
1882 — B0136 Structure Function
Relationship: ganglion cell complex assessment
by two SD-OCT and standard automated
perimetry. Hussam El Chehab, M. Delbarre, R.
Messaoudi, J. Fenolland, M. Marie, M. Francoz,
J. Giraud, F. May, J. G. Renard. Department of
Ophthalmology, Hospital Val de Grace, Paris,
France
1883 — B0137 Structure-Function Mapping:
Conviction and Variability in Tracing of Retinal
Nerve Fibre Bundles and Comparison to a
Computational Model. Jonathan Denniss1, 2,
A. Turpin2, F. Tanabe3, C. Matsumoto3, A. M.
McKendrick1. 1Optometry and Vision Sciences,
The University of Melbourne, Melbourne, VIC,
Australia; 2Computing and Information Systems,
The University of Melbourne, Melbourne, VIC,
Australia; 3Ophthalmology, Kinki University
Faculty of Medicine, Osaka, Japan *CR
1884 — B0138 Autoregressive Mixed Effects
Approach for Modeling Longitudinal Standard
Automated Perimetry Data in Glaucoma. Manoj
Pathak, S. Demirel, S. K. Gardiner. Devers Eye
Institute, Legacy Research Institute, Portland, OR
*CR
1885 — B0139 Signal-to-Noise Ratios for
Structural and Functional Tests in Glaucoma.
Cindy L. Blachly, S. K. Gardiner, B. Fortune, D.
Goren, M. D. Whitworth, S. L. Mansberger, S.
Demirel. Devers Eye Institute, Legacy Health,
Portland, OR *CR
1886 — B0140 Detectability of Visual Field
Defects using 0.5 Degree Interval in High
Resolution Perimetry and OCT Findings. Takuya
Numata1, C. Matsumoto1, S. Okuyama1, S. Takada1,
F. Tanabe1, S. Hashimoto1, M. Eura1, T. Kayazawa1,
E. Koike2, Y. Shimomura1. 1Ophthalmology, Kinki
University Faculty of Medicine, Osaka-Sayama,
Japan; 2Sakai Hospital Kinki University Faculty of
Medicine, Sakai, Japan
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
147
Monday Posters
11:00 am – 12:45 pm
1869 — B0123 Outcome of
Combined Phacoemulsification and
Endocyclophotocoagulation in Glaucoma.
Faisal A. AlMobarak. Ophthalmology, King Saud
University, Riyadh, Saudi Arabia
1875 — B0129 Dynamic iris volume
characteristics pre and post laser peripheral
iridotomy (LPI) in eyes with occludable anterior
chamber angles measured with 3 dimensional
swept-source Ocular Coherence Tomography
(OCT): The Investigating Management of Angle
Closure and Treatment (IMPACT) study. Rupert
R. Bourne1, 2, L. Sanchez Parra1, H. Shahid3, R.
Buckley1, S. Pardhan1. 1Vision & Eye Research
Unit, Postgraduate Medical Institute, Anglia
Ruskin University, Cambridge, United Kingdom;
2
Huntingdon Glaucoma Diagnostic & Research
Centre, Hinchingbrooke Hospital, Huntingdon,
United Kingdom; 3Ophthalmology, University
of Cambridge Hospitals NHS Trust, Cambridge,
United Kingdom *CR, f
1887 – 1904 – Monday – Posters
Monday Posters
11:00 am – 12:45 pm
1887 — B0141 The Combined Structure and
Function Index as a Predictor of Glaucoma
Development. Daniel Meira-Freitas1, 2, R. Lisboa1, 2,
A. J. Tatham1, L. M. Zangwill1, R. N. Weinreb1,
C. A. Girkin3, J. M. Liebmann4, T. T. Kuang1, 5,
C. Bowd1, F. A. Medeiros1. 1Hamilton Glaucoma
Center, Department of Ophthalmology, University
of California, San Diego, La Jolla, CA; 2Department
of Ophthalmology, Federal University of São Paulo,
São Paulo, Brazil; 3Department of Ophthalmology,
University of Alabama, Birmingham, AL;
4
Department of Ophthalmology, New York Eye
and Ear Infirmary, New York, NY; 5Department of
Ophthalmology, Taipei Veterans General Hospital,
Taipei, Taiwan *CR
1888 — B0142 Reproducibility of In Vivo
Laminar and Pre-laminar Tissues Measurements
with Enhanced Depth Imaging Spectral-Domain
Optical Coherence Tomography. Vitor G. Prado,
P. D. Silva, P. D. Borba, I. Matsubara, A. Paranhos,
R. M. Vessani, T. S. Prata. Ophthalmology, Federal
Univ of Sao Paulo, Sao Paulo, Brazil *CR
1889 — B0143 The Impact of Lens Vault on
Visual Acuity and Refractive Error in Subjects
with Angle Closure. Shweta Singhal1, S. Stewart2,
M. E. Nongpiur1, 3, H. M. Htoon1, 3, S. Perera1,
T. Aung1, 4. 1Singapore Eye Research Institute
and Singapore National Eye Centre, Singapore,
Singapore; 2University College London, London,
United Kingdom; 3Duke-NUS Graduate Medical
School, Singapore, Singapore; 4Yong Loo Lin
School of Medicine, National University of
Singapore, Singapore, Singapore *CR
1890 — B0144 The optic nerve head: does size
matter? Barbara Zangerl, E. Y. Wong, N. Yoshioka,
M. P. Hennessy, M. Kalloniatis. Centre for Eye
Health, School of Optometry and Vision Science,
The University of New South Wales, Kensington,
NSW, Australia
1891 — B0145 Predicting standard automated
perimetry (SAP) sensitivities from spectral
domain optical coherence tomography (SD-OCT)
retinal nerve fiber layer thickness (RNFLT)
using temporally correlated data. Lisha Deng,
D. Goren, M. Pathak, S. Demirel, S. K. Gardiner.
Discoveries in Sight, Devers Eye Institute, Portland,
OR *CR
1892 — B0146 Optic Nerve and Lateral
Geniculate Body in Glaucoma and its
Association With Functional an Structural
Ocular AlterationS. Augusto Paranhos1, 2, R. L.
Furlanetto1, S. H. Teixeira1, 2, C. L. Lottenberg2, 1,
D. B. Almeida-Freitas2, 1, E. Amaro2, 1. 1Oftalm-Inst
da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo,
Brazil; 2Hospital Israelita Albert Einstein, Sao
Paulo, Brazil *CR
1893 — B0147 Relationship Between Relative
Afferent Pupillary Defect with Pupillography
and Ganglion Cell Complex Thickness by
Optical Coherence Tomography in Asymmetric
Glaucoma. Naoki Ozeki, K. Yuki, D. Shiba, K.
Tsubota. Keio University, Tokyo, Japan *CR
1894 — B0148 Retinotopic-specific changes
of cerebral blood flow and grey matter density
in visual cortex of patients with glaucoma.
Zhang Shaodan1, 4, B. Wang2, Y. Xie3, C. Zhang4,
N. Wang3. 1Department of Ophthalmology, The 4th
People’s Hospital of Shenyang, Shenyang, China;
2
State Key Laboratory of Brain and Cognitive
Science, Institute of Biophysics, Chinese Academy
of Sciences, Beijing, China; 3Beijing TongRen
Eye Center, Beijing TongRen Hospital, Capital
Medical University, Beijing, China; 4Department of
Ophthalmology, Peking University Third Hospital,
Peking University Health Science Center, Beijing,
China
1895 — B0149 Dynamic iris volume
characteristics in the physiological range of pupil
size and reproducibility of measurements in eyes
with occludable anterior chamber angles: The
Investigating Management of Angle Closure and
Treatment (IMPACT) study. Humma Shahid1,
L. Sanchez Parra2, 3, R. Buckley2, S. Pardhan2,
R. R. Bourne1, 2. 1Ophthalmology, University of
Cambridge Hospitals NHS Trust, Cambridge,
United Kingdom; 2Vision & Eye Research Unit,
Anglia Ruskin University, Cambridge, United
Kingdom; 3Huntingdon Glaucoma & Diagnostic
Research Centre, Hinchingbrooke Hospital,
Huntingdon, United Kingdom *CR, f
1896 — B0150 Comparison of optic disc
parameters obtained by simultaneous stereo
fundus photography and spectral domain
optical coherence tomography. Aiko Iwase1, T.
Nakagawa3, M. Araie2. 1Tajimi Iwase Eye Clinic,
Tajimi, Japan; 2Kanto Central Hospital, Tokyo,
Japan; 3Kowa, Co. Ltd., Hamamatsu, Japan *CR
1897 — B0151 Stereometric parameters of
optic disc. Comparison between the Heildelberg
Retina Tomograph and Three-Dimensional
Optical Coherence Tomography. Claudia Castillo
Ayometzi, F. Ortega Santana, A. García López.
Hosp Nuestra Senora de la Luz, Mexico, Mexico
1898 — B0152 Longitudinal Analysis of
Glaucoma Progression by Structure and
Function: 7-year Follow-Up by Visual Field (VF)
and Optical Coherence Tomography (OCT). Igor
I. Bussel1, G. Wollstein1, R. A. Bilonick1, 2, Y. Ling1, 2,
H. Ishikawa1, 3, J. E. Nevins1, L. Kagemann1, 3, J.
S. Duker4, C. Mattox4, J. S. Schuman1, 3. 1UPMC
Eye Center, Eye and Ear Institute, Ophthalmology
and Visual Science Research Center, Department
of Ophthalmology, University of Pittsburgh
School of Medicine, Pittsburgh, PA; 2Department
of Biostatistics, Graduate School of Public
Health, University of Pittsburgh, Pittsburgh, PA;
3
Department of Bioengineering, Swanson School of
Engineering, University of Pittsburgh, Pittsburgh,
PA; 4New England Eye Center, Tufts Medical
Center, Boston, MA *CR
1899 — B0153 Use of Optical Coherence
Tomography in Clinical Practice: Does it
Influence the Diagnostic Decision of Glaucoma
Specialists and Non-specialists? Carlos E.
Barbosa, L. G. Biteli, R. M. Vessani, M. T. Leite, A.
Paranhos, T. S. Prata. UNIFESP, São Paulo, Brazil
*CR
1900 — B0154 Bayesian Hierarchical
Modelling of Longitudinal Visual Fields to
Quantify Glaucoma Progression. Susan R.
Bryan1, 2, K. A. Vermeer1, P. H. Eilers2, H. G.
Lemij3, E. Lesaffre2, 4. 1Rotterdam Ophthalmic
Institute, Rotterdam, Netherlands; 2Biostatistics,
Erasmus Medical Center, Rotterdam, Netherlands;
3
Glaucoma Service, Rotterdam Eye Hospital,
Rotterdam, Netherlands; 4L-Biostat, KU Leuven,
Leuven, Belgium *CR
1901 — B0155 Effect of ocular curvature and
myopia on retinal blood flow: a theoretical study.
Andrea Dziubek1, G. Guidoboni2, A. N. Hirani3, A.
Harris4. 1Engineering, Science, Mathematics, State
University of New York Institute of Technology,
Utica, NY; 2Mathematics, Indiana University
Purdue University Indianapolis, Indianapolis, IN;
3
Computer Science, University of Illinois at UrbanaChampaign, Urbana, IL; 4Opthalmology, Indiana
University School of Medicine, Indianapolis, IN
*CR
1902 — B0156 Relationship between the
macular ganglion cell complex thickness and
standard automated perimetry in glaucoma.
Antonio Ferreras1, 2, B. Monsalve3, P. Calvo4,
A. B. Pajarin5, P. Frezzotti6, P. Fogagnolo7, M.
Figus8, M. M. Iester9. 1Ophthalmology, Miguel
Servet University Hospital, Zaragoza, Spain;
2
Ophthalmology, University of Zaragoza, Zaragoza,
Spain; 3Ophthalmology, Hospital General
Universitario Gregorio Marañon, Madrid, Spain;
4
Ophthalmology, Toronto Western hospital, Toronto,
ON, Canada; 5Family medicine, Centro de Salud
Casablanca, Zaragoza, Spain; 6Ophthalmology,
University of Siena, Siena, Italy; 7Ophthalmology,
G.B. Bietti Foundation-IRCCS, Rome, Italy;
8
Neuroscience, University of Pisa, Pisa, Italy;
9
Ophthalmology, University of Genoa, Genoa, Italy
*CR
1903 — B0157 Does Cerebrospinal Fluid
Communicate with the Eye? Emily Mathieu1, 2,
N. Gupta2, 4, R. Macdonald1, 3, J. Ai1, 3, Y. H.
Yucel1, 2. 1Keenan Research Centre at the Li Ka
Shing Knowledge Institute, St. Michael’s Hospital,
Toronto, ON, Canada; 2Ophthalmology & Vision
Sciences, Laboratory Medicine and Pathobiology,
University of Toronto, Toronto, ON, Canada;
3
Surgery, Division of Neurosurgery, St. Michael’s
Hospital, University of Toronto, Toronto, ON,
Canada; 4Glaucoma & Nerve Protection Unit, St.
Michael’s Hospital, Toronto, ON, Canada
Exhibit Hall B0271-B0285
Monday, May 06, 2013 11:00 AM-12:45 PM
Anatomy/Pathology
253 Myopia I, AP
Moderator: Thomas T. Norton
1904 — B0271 The effect of horizontal eye
movements on changes in central refraction.
Arne Ohlendorf1, J. Gehrmann2, R. E. Sessner1.
1
Technology and Innovation, Carl Zeiss Vision,
Aalen, Germany; 2Course of Optometry, University
of Applied Sciences Aalen, Aalen, Germany *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
148
Monday – Posters – 1905 – 1925
1905 — B0272 Prognostic factors associated
with pathological myopia in young patients
with high myopia. Tae Yokoi1, 2, M. Moriyama1,
N. Shimada1, 2, N. Nagaoka1, K. Kasahara1, K.
Shinohara1, Y. Tanaka1, Y. Kaneko1, T. Tokoro1, K.
Ohno-Matsui1. 1Departments of Ophthalmology
& Visual Science, Tokyo Medical and Dental
University Graduate School of Medicine and Dental
Sciences, Bunkyou-ku, Japan; 2Department of
Ophthalmology, Kawaguchi Municipal Medical
Center, Kawaguchi-shi, Japan
1907 — B0274 Outer nuclear layer and
retinal layer ratios in myopic and emmetropic
populations using spectral domain optical
coherence tomography. Christopher A. Clark,
A. E. Elsner, B. Konynenbelt, J. A. Papay, T. Y.
Chui. School of Optometry, University of Indiana,
Bloomington, IN *CR
1908 — B0275 Extended Clinical Phenotype
of Dome-Shaped Macula. Marie-Helene Errera,
M. Michaelides, P. A. Keane, A. T. Moore, J. Yeoh,
D. Chan, C. A. Egan, P. J. Patel, A. Tufail. NIHR
Biomedical Research Centre for Ophthalmology,
Moorfields Eye Hospital NHS Foundation Trust and
UCL Institute of Ophthalmology., London, United
Kingdom *CR
1909 — B0276 Thinning of Lens Thickness
Might Be Responsible for Myopia Development.
Ji C. He. New England College of Optometry,
Boston, MA
1910 — B0277 Increased Lens Opacities
Associated with the Use of Topical Atropine for
Myopia Retardation in Children. Francine P.
Yang1, F. Foo1, S. Leo1, 2. 1Ophthalmology, Tan Tock
Seng Hospital, Singapore, Singapore; 2Dr Leo Adult
and Paediatric Eye Specialist Pte Ltd, Singapore,
Singapore
1913 — B0280 Optical coherence tomographybased evaluation of peripapillary tilting in
highly myopic eyes. Tomoko Asai1, Y. Ikuno1, M.
Akiba2, T. Kikawa2, Y. Jo1, S. Usui1, K. Nishida1.
1
Ophthalmology, Osaka Univ Grad Sch of Med,
Suita, Japan; 2TOPCON Corp., Itabashi, Japan *CR
1914 — B0281 Contributions of Eye Power and
Optical Eye Length to Emmetropization during
Lens Induced Myopia and Recovery in the Chick
Eye. Zheng Shao1, 2, K. Bunghardt1, M. L. Kisilak1,
3
, E. L. Irving1, 3, M. C. Campbell1, 3. 1Physics and
Astronomy, University of Waterloo, Waterloo,
ON, Canada; 2Guelph Waterloo Physics Institute,
Waterloo, ON, Canada; 3School of Optometry and
Vision Science, University of Waterloo, Waterloo,
ON, Canada *CR
1915 — B0282 Pattern ERG in chicks. Lisa
A. Ostrin, C. F. Wildsoet. School of Optometry,
University of California Berkeley, Berkeley, CA
1916 — B0283 Manual segmentation of
choroidal volume in emmetropic and high
myopic eyes. Su-Na Lee1, 2, G. Barteselli1, S. ElEmam1, H. Hou1, D. G. Bartsch1, L. Cheng1, W.
Freeman1. 1Ophthalmology, Shiley Eye Center,
UCSD, La Jolla, CA; 2Ophthalmology, Eulji
University Hospital, Daejeon, Republic of Korea
*CR
1917 — B0284 Strain differences in mouse
lens refractive indices when measured with
OCT. Christopher C. Tan1, H. Park1, J. G.
Light1, K. Lacy2, M. T. Pardue1, 2. 1Department
of Ophthalmology, Emory Univ School of Med,
Atlanta, GA; 2Rehab Center of Excellence, Atlanta
VA Medical Center, Atlanta, GA
1918 — B0285 Isoflurane and lid retractors
affect the optics of the chick eye. Marsha L.
Kisilak1, 2, K. Bunghardt1, V. Choh2, E. L. Irving2, M.
C. Campbell1, 2. 1Physics & Astronomy, University
of Waterloo, Waterloo, ON, Canada; 2School of
Optometry and Vision Science, University of
Waterloo, Waterloo, ON, Canada *CR
1911 — B0278 Short-term adaptation of
accommodative lag, facility and phoria in
myopes fitted with multifocal contact lenses.
Jerome Ozkan1, R. C. Bakaraju1, C. Fedtke1, J.
Chung1, K. Ehrmann1, 2, D. Falk1, A. Ho1, 2, B. A.
Holden1, 2. 1Brien Holden Vision Institute, Sydney,
NSW, Australia; 2School of Optometry and Vision
Science, University of New South Wales, Sydney,
NSW, Australia *CR, f
Exhibit Hall B0316-B0333
Monday, May 06, 2013 11:00 AM-12:45 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
254 Strabismus/Eye Movements:
Central and Peripheral Factors
Moderator: Vallabh E. Das
1919 — B0316 Effect of oculomotor
rehabilitation on vergence responsivity in mild
traumatic brain injury (mTBI). Kenneth J.
Ciuffreda, P. Thiagarajan. Biological and Vision
Sciences, SUNY College of Optometry, New York,
NY
1920 — B0317 Effect of oculomotor
rehabilitation on basic versional eye movements
and reading in mild traumatic brain injury
(mTBI). Preethi Thiagarajan1, K. J. Ciuffreda1,
D. P. Ludlam1, N. Kapoor1, J. E. Capo-Aponte2.
1
Biological and Vision Sciences, State University of
New York, State College of Optometry, New York,
NY; 2Optometry, Womack Army Medical Center,
Fort Bragg, NC
1921 — B0318 Comparison of Smooth Pursuit
and Saccadic Testing in Screening for Mild
Traumatic Brain Injury. Jonathan B. Jacobs1, 2, M.
M. Skelly1. 1Daroff-Dell’Osso Ocular Motility Lab,
Cleveland VA Med Ctr, Cleveland, OH; 2Neurology
& Biomedical Engineering, Case Western Reserve
University, Cleveland, OH
1922 — B0319 The Effect of Combat-Related
Mild TBI on Saccadic Eye Movements. Paul
A. Wetzel1, R. C. Pallansch1, G. T. Gitchel1, 3, D.
X. Cifu2, 3. 1Dept. of Biomedical Engineering,
Virginia Commonwealth University, Richmond,
VA; 2Dept. of Physical Medicine and Rehabilitation,
Virginia Commonwealth University, Richmond,
VA; 3McGuire Veterans Affairs Medical Center,
Richmond, VA
1923 — B0320 Magnetic resonance imaging
(MRI) features of partial or complete avulsion
of the inferior rectus (IR) muscle. Sylvia Yoo1,
J. L. Demer1, 2. 1Ophthalmology, Jules Stein Eye
Institute, Los Angeles, CA; 2Neurology, University
of California Los Angeles, Los Angeles, CA *CR
1924 — B0321 Three-dimensional magnetic
resonance analysis of extraocular muscles
demonstrates gaze-specific contractile shape
changes. Michelle Y. Peng1, R. B. Geary1, S. Ying2,
D. S. Zee2, P. Barker3, H. S. Ying1. 1Ophthalmology,
Wilmer Eye Institute, Baltimore, MD; 2Neurology,
Johns Hopkins University, Baltimore, MD;
3
Radiology, Johns Hopkins University, Baltimore,
MD
1925 — B0322 Poisson Ratio Measurements
of Extra-ocular Muscle and Tendon. Andrew
Shin1, 2, L. Yoo1, J. L. Demer1. 1Ophthalmology,
Jules Stein Eye Institute, UCLA, Los Angeles, CA;
2
Mechanical and Aerospace Engineering, UCLA,
Los Angeles, CA *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
149
Monday Posters
11:00 am – 12:45 pm
1906 — B0273 Axial Length and its
Associations in an Adult Japanese Population:
The Funagata Study. Akira Sugano1, Y. Tanabe1,
K. Saito1, K. Homma1, R. Kawasaki1, 2, T. Kato3,
T. Kayama4, 5, H. Yamashita1, 5. 1Ophthalmology,
Yamagata University Sch of Med, Yamagata, Japan;
2
Department of Public Health, Yamagata University
Sch of Med, Yamagata, Japan; 3Department of
Neurology, Hematology, Metabolism, Yamagata
University Sch of Med, Yamagata, Japan;
4
Department of Neurosurgery, Yamagata University
Sch of Med, Yamagata, Japan; 5Global COE
Program for Medical Sciences, Japan Society for
the Promotion of Science, Yamagata, Japan *CR
1912 — B0279 Intraocular Pressure in Myopic
Eyes during the Water Drinking Test. Barbara M.
Junghans1, 2, C. Chang1, A. Siu1, N. C. Soesanto1, M.
F. Tu1, M. J. Murphy2, S. G. Crewther2, 1. 1School of
Optometry and Vision Science, Univ of New South
Wales, UNSW Sydney, NSW, Australia; 2School
of Psychological Science, La Trobe University,
Melbourne, VIC, Australia
1926 – 1949 – Monday – Posters
1926 — B0323 Intra-sarcomeric Cytoskeleton
and M-band Proteins in the Human Extraocular
Muscles. Adrihan H. Janbaz, F. Pedrosa Domellof.
Anatomy, Clinical Sciences, Ophthalmology, Umea,
Sweden
1927 — B0324 Satellite cells in extraocular
muscles of ALS patients. Fatima Pedrosa
Domellof1, M. M. Lindstrom2, A. Tjust1, 2. 1Clinical
Sciences, Ophthalmology, Umea University, Umea,
Sweden; 2Integrative Medical Biology, Anatomy,
Umea University, Umea, Sweden
Monday Posters
11:00 am – 12:45 pm
1928 — B0325 Sources of tonic firing
properties of saccade-related cerebellar neurons.
Adrienne Mueller, R. Robinson. University of
Washington, Seattle, WA
1929 — B0326 Response properties of Frontal
Eye Field (FEF) neurons during volitional
smooth pursuit and optokinetic eye movements.
Leah Bakst1, 2, L. Brostek3, S. Glasauer3, S. Ono1, 2,
M. J. Mustari1, 2. 1Opthalmology, Unveristy of
Washington, Seattle, WA; 2Washington National
Primate Research Center, University of Washington,
Seattle, WA; 3Clinical Neuroscience, University of
Munich, Munich, Germany
1930 — B0327 Electrical microstimulation of
the deep superior colliculus (SC) in strabismic
monkeys. Jérome Fleuriet, M. Walton, S. Ono,
M. J. Mustari. Department of Ophthalmology and
Washington National Primate Research Center,
University of Washington, Seattle, WA
1931 — B0328 Neural Mechanisms for smooth
pursuit and vestibular ocular behavior in
strabismic monkeys. Michael J. Mustari1, 2, S.
Ono1, 2. 1Department of Ophthalmology, University
of Washington, Seattle, WA; 2Washington National
Primate Research Center, University of Washington,
Seattle, WA
1932 — B0329 Smooth pursuit adaptation
in strabismic monkey with developmental
esotropia. Seiji Ono1, 2, M. J. Mustari1, 2.
1
Department of Ophthalmology, University of
Washington, Seattle, WA; 2Washington National
Primate Research Center, University of Washington,
Seattle, WA
1933 — B0330 Comparison of Naso-Temporal
Asymmetries in Optokinetic, Smooth-Pursuit
and Ocular Following Eye Movements in
Monkeys with Strabismus. Anand C. Joshi1, M.
N. Agaoglu1, 2, E. N. Baskin1, H. M. Queener1, V.
E. Das1, 2. 1College of Optometry, University of
Houston, Houston, TX; 2College Of Engineering,
University of Houston, Houston, TX
1934 — B0331 Associations between central
nervous system disorder and congenital
esotropia. Sjoukje E. Loudon1, J. Dudink2, L. S.
Smit3, J. Polling1, H. J. Simonsz1. 1Ophthalmology,
ErasmusMC Univ Medical Ctr, Rotterdam,
Netherlands; 2Neonatology, Sophia’s Childrens
Hospital, ErasmusMC, Rotterdam, Netherlands;
3
Pediatric Neurology, Sophia’s Childrens Hospital,
ErasmusMC, Rotterdam, Netherlands
1935 — B0332 Niemann-Pick type C.
An Expanding Spectrum of Ophthalmic
Involvement. Sophia Saleem, S. A. Newman.
Ophthalmology, University of Virginia,
Charlottesville, VA
1936 — B0333 Orbital imaging in
craniosynostosis: Understanding the
pathophysiology of complex strabismus.
Maria Carolina Ortube, F. G. Velez, J. L. Demer.
Ophthalmology, Jules Stein Eye Institute, UCLA,
Los Angeles, CA *CR
Exhibit Hall C0151-C0182
Monday, May 06, 2013 11:00 AM-12:45 PM
Physiology/Pharmacology / Biochemistry/
Molecular Biology
255 Retina/RPE: New Drugs,
Mechanisms of Action, and Toxicity
Moderators: Achim H. Krauss and
Michele Reibaldi
1937 — C0151 Optimization of Cone-Directed
AAV-Mediated Gene Augmentation Therapy
for CNGB3-Achromatopsia by Use of the IRBP/
GNAT2-Promoter and Intravitreal CNTF
Administration. Connie Y. Yeh1, 2, S. Iwabe1, S. L.
Boye3, K. McDaid1, C. Harman2, R. Wen4, W. W.
Hauswirth3, A. M. Komaromy1, 2, G. D. Aguirre1.
1
School of Veterinary Medicine, University of
Pennsylvania, Philadelphia, PA; 2College of
Veterinary Medicine, Michigan State University,
East Lansing, MI; 3College of Medicine, University
of Florida, Gainesville, FL; 4Bascom Palmer Eye
Institute, University of Miami, Miami, FL *CR
1938 — C0152 Conversion to aflibercept for
chronic refractory or recurrent neovascular
age-related macular degeneration. Yoshihiro
Yonekawa1, J. B. Miller1, J. I. Loewenstein1, L.
Sobrin1, D. Eliott1, D. Vavvas1, J. W. Miller1, C. M.
Andreoli1, 2, I. K. Kim1. 1Massachusetts Eye and Ear
Infirmary, Boston, MA; 2Harvard Vanguard Medical
Associates, Boston, MA *CR
1939 — C0153 Effective Targeting of the
PI3K/AKT/mTOR Pathway: A Promising
Therapeutic Option for the Treatment of Ocular
Neovascularization/Inflammation/Oedema.
Temitope Sasore, A. L. Reynolds, B. N. Kennedy.
Conway Institute, University College Dubin, Dublin
4, Ireland *CR
1940 — C0154 Comparison of the toxicity of
different drug delivery nanoparticles in RPE
and photoreceptor cells. Yueran Yan, H. Lin, H.
Matsumoto, P. Bouzika, J. W. Miller, D. Vavvas.
Massachusetts Eye and Ear Infirmary, Harvard
Medical School, Boston, MA *CR
1941 — C0155 A Wnt Inhibitor for Treatment
of Diabetic Retinopathy. Danyang Chen, E. Little.
Charlesson, LLC, Oklahoma City, OK *CR
1942 — C0156 Impact of Ocriplasmin Therapy
in Symptomatic Vitreomacular Adhesion (VMA)
Patients Considered to be Clinical Candidates
for Vitrectomy. Baruch D. Kuppermann. Gavin
Herbert Eye Inst Dept Ophthal, University of
California Irvine, Irvine, CA *CR, f
1943 — C0157 Schisandrin B Improves
the Visual Motor Response and Preserves
Photoreceptors in the Zebrafish PDE6C Cone
Dystrophy Mutant. Yuk Fai Leung1, 3, L. Zhang1,
L. Chong1, J. Cho1, K. Ko2. 1Biological Sciences,
Purdue University, West Lafayette, IN; 2Division
of Life Science, The Hong Kong University of
Science & Technology, Hong Kong, Hong Kong;
3
Biochemistry and Molecular Biology, Indiana
University School of Medicine Lafayette, West
Lafayette, IN
1944 — C0158 Phase I, Randomized, DoubleMasked, Vehicle-Controlled Study to Evaluate
Safety, Tolerability and Pharmacokinetics of
Recombinant Human Nerve Growth Factor Eye
Drops in Healthy Volunteers. Ronald R. Buggage,
P. A. Ruffini, M. P. Ferrari. Dompe S.p.A., Milan,
Italy *CR, f
1945 — C0159 Antiglycating potential of
procyanidin-B2 isolated from cinnamon bark:
Prevention or treatment of diabetic ocular
complications (cataract & retinopathy). G
Bhanuprakash Reddy, P. Muthenna, C. Akileshwari,
G. Raghu, P. Suryanarayana. Biochemistry,
National Institute of Nutrition, Hyderabad, India
*CR
1946 — C0160 Effects of resveratrol,
epigallocatechine gallate (EGCG) and curcumin
on the proliferation of human retinal endothelial
cells in vitro. Anne F. Alex1, M. Spitznas2, C. Kurts3,
N. Eter1. 1Department of Ophthalmology, University
of Muenster Medical Center, Muenster, Germany;
2
Department of Ophthalmology, University of
Bonn Medical Center, Bonn, Germany; 3Institutes
of Molecular Medicine and Experimental
Immunology, University of Bonn Medical Center,
Bonn, Germany *CR
1947 — C0161 Circulating miRNAs as
Biomarkers of Retinal Toxicity. Qinghai Peng,
W. Huang, W. Collette, M. Twamley, S. Aguirre, A.
John-Baptiste. Pfizer, San Diego, CA *CR
1948 — C0162 Comparison of intraocular
retinal pigment epithelial (RPE) cell injections in
vitrectomized wild type pigs. Elliott H. Sohn1, 2, C.
Jiao2, R. F. Mullins2, W. Jung2, S. R. Russell1, 2, E. M.
Stone1, 2, B. A. Tucker2. 1Retina Service, University
of Iowa Hospitals & Clinics, Iowa City, IA;
2
Institute for Vision Research, University of Iowa,
Iowa City, IA *CR
1949 — C0163 Assessment of the therapeutic
value of phloroglucinol in Stargardt’s disease.
Philippe Brabet1, D. Cia2, C. Vigor3, N. Jacquemot2,
B. Lerat1, L. Guillou1, C. Crauste3, C. P. Hamel1,
J. L. Vercauteren3. 1Institute for Neurosciences of
Montpellier, INSERM U1051, Montpellier, France;
2
Laboratoire de Biophysique Neurosensorielle,
UMR Inserm 1107, Clermont-Ferrand, France;
3
Institut des Biomolécules Max Mousseron
(IBMM), UMR CNRS 5247, Montpellier, France
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
150
Monday – Posters – 1950 – 1973
1959 — C0173 Clinical and Diagnostic Imaging
Features of Anti-Retroviral Therapy (ART)Associated Retinopathy. Alcides Fernandes1, J. F.
Payne3, S. K. Srivastava2, S. Yeh1. 1Ophthalmology,
Emory University, Atlanta, GA; 2Cole Eye Institute,
Cleveland Clinic, Cleveland, OH; 3Ophthalmology,
Palmetto Retina Center, LLC, West Columbia, SC
*CR
1967 — C0181 Fragment crystallizable (Fc)
region results in an increased systemic exposure
with no significant difference in intra-ocular
pharmacokinetics. Jennifer Le Couter, K. Gadkar,
J. Elliott, T. Lee, Y. Meng, L. Zhang, M. Kenrick,
S. Prabhu, J. M. Scheer. Tumor Biology and
Angiogenesis, Genentech, Inc, San Francisco, CA
*CR
1951 — C0165 Increasing mitochondrial
respiratory capacity is protective in models
of photoreceptor cell degeneration. Mausumi
Bandyopadhyay1, N. R. Perron2, C. Nasarre1, C.
Beeson2, B. Rohrer1. 1Ophthalmology, Medical
University of South Carolina, Charleston, SC;
2
Pharmaceutical Sciences, Medical University of
South Carolina, Charleston, SC *CR
1960 — C0174 S/MAR containing
nanoparticles mediate long-term therapeutic
gene targeting in the RPE and rescue the rpe65/LCA model. Shannon M. Conley1, A. Koirala1, R.
Makkia1, Z. Liu2, M. J. Cooper3, J. R. Sparrow2, M.
I. Naash1. 1Cell Biol, Hlth Sci Ctr-BMSB 781, Univ
of Oklahoma, Oklahoma City, OK; 2Department of
Ophthalmology, Columbia University, New York,
NY; 3Copernicus Therapeutics, Cleveland, OH *CR
1968 — C0182 Effect of an Antioxidant Blend
in Diabetic Macular Edema. Salvatore Faro1,
T. Avitabile1, G. Malaguarnera2, F. Marco Livio1,
M. G. Uva1, M. Cicinelli3, C. Cassar Scalia1, E.
Lionetti1, C. Gagliano3. 1Ophthalmology, University
of Catania, Catania, Italy; 2Clinical and Molecular
Biomedicine, University of Catania, Catania, Italy;
3
NEST, Neurovisual Science Technology, Catania,
Italy
1961 — C0175 Analysis of the binding affinity
of vascular endothelial growth factor A (VEGF)
to ranibizumab, aflibercept and bevacizumab.
Xiangdan Wang, J. Yang. Genentech, Inc., South
San Francisco, CA *CR
Exhibit Hall C0183-C0220
1952 — C0166 A deca-peptide inhibits retinal
neovascularization by down-regulation of VEGF
and up-regulation of PEDF in OIR mouse. Xun
Xu. Department of Ophthalmology, Shanghai First
People’s Hospital, Shanghai, China
1953 — C0167 Novel GFAP Species in Retinal
Gliosis. John Wizeman, P. Bargagna-Mohan, S.
O’Rourke, R. Mohan. Neuroscience, University of
Connecticut Health Center, Farmington, CT *CR
1954 — C0168 Effect of Intravitreal Injection
of Iodoacetic Acid in Mice as a Model of
Pharmacological Induced Monolateral
Photoreceptor Degeneration. Sarah Roesch1, S.
Hesse1, C. Haselier1, B. A. Mazinani1, G. Roessler1,
C. Pfarrer2, P. Walter1. 1Ophthalmic clinic,
University hospital RWTH, Aachen, Germany;
2
University of Veterinary medicine Hannover,
Anatomical Institute, Hannover, Germany *CR
1955 — C0169 Phlorotannin-Rich Natural
Extract From Brown Seaweed Ascophyllum
Nodosum Prevents In Vitro High Glucose Retinal
Damages. Melody Dutot1, R. Fagon1, P. Rat2.
1
Research&Development, YSLAB, Paris, France;
2
Chimie-Toxicologie Analytique et Cellulaire (EA
4463), Faculté de Pharmacie, Université Paries
Descartes, Paris, France *CR
1956 — C0170 Fenretinide Inhibits Ocular
Neovascularization (NV) by Upregulation of
Bone Morphogenic Protein-2 (BMP-2) and
Reduction of Inflammatory Macrophages and
VEGF. Rebecca K. Stevens1, P. A. Campochiaro1,
J. Shen1, B. C. Oveson1, S. F. Hackett1, N. L.
Mata2. 1Ophthalmology, Johns Hopkins University,
Baltimore, MD; 2Acucela Inc., Seattle, WA *CR
1957 — C0171 Blocking the necroptosis
pathway decreases RPE and photoreceptor
damage induced by NaIO3. Haijiang Lin, M.
Roh, H. Matsumoto, A. H. Alhatem, P. Bouzika, Y.
Murakami, J. W. Miller, D. Vavvas. Ophthalmologyretina, Massachusetts Eye and Ear, Harvard Medical
School, Boston, MA *CR
1958 — C0172 Impact of intravitreal
dexamethasone implant (Ozurdex) on macular
morphology and function. Maria Lucia
Cascavilla1, G. Querques1, 2, R. Lattanzio1, L.
Querques1, G. Triolo1, E. Cavallero1, F. Bandello1.
1
Scientific Inst San Raffaele, Segrate-Mi2, Italy;
2
University Paris-Est Creteil, Parigi, France *CR
1962 — C0176 Low dose acetyl salicyl
acid as a treatment option for central serous
chorioretinopathy. Nicole Stuebiger. Department
of Ophthalmology, Charite, University Medicine
Berlin, Berlin, Germany
1963 — C0177 Ceramide Biosynthesis
Inhibition Protects the Retina from LightInduced Degeneration. Md Nawajes A. Mandal1, 2,
H. Chen1, 3, J. Tran1, 2, M. H. Elliott1, 2, R. S.
Brush1, 2. 1Ophthalmology, Univ of Oklahoma Hlth
Sci Ctr, Oklahoma City, OK; 2Dean McGee Eye
Institute, Oklahoma City, OK; 3Ophthalmology,
Sichuan Academy of Medical Sciences & Sichuan
Provincial People’s Hospital, Chengdu City, China
*CR
1964 — C0178 Ocriplasmin as an Adjunct
to Vitrectomy for the Treatment of Pediatric
Patients: Results of the MIC Trial. Emmanuel
Chang. Ophthalmology, Associated Retinal
Consultants, Royal Oak, MI f
1965 — C0179 Quinic Acid Derivative, KZ41 Protects Against Radiation-Induced Retinal
Endothelial Cell Dysfunction: An Early - to Late Stage Treatment of Radiation Retinopathy.
Jordan J. Toutounchian1, Q. Zhang2, J. Pagadala1,
D. D. Miller1, J. J. Steinle2, C. R. Yates1.
1
Pharmaceutical Sciences, Univ of Tennessee Hlth
Sci Ctr, Memphis, TN; 2Ophthalmology, Univ of
Tennessee Hlth Sci Ctr, Memphis, TN *CR
1966 — C0180 Safety of intravitreal
quinupristin / dalfopristin in an animal model.
Veronica E. Giordano, S. Hernandez-Da Mota,
J. Guerrero-Naranjo, T. N. Adabache Guel, S.
Salinas Longoria, S. Corredor-Casas, G. SalcedoVillanueva, J. Jimenez-Sierra, V. Morales-Canton.
Retina, Asociación para evitar la Ceguera en
Mexico, Distrito Federal, Mexico *CR
Monday, May 06, 2013 11:00 AM-12:45 PM
Physiology/Pharmacology
256 Aqueous Humor Dynamics
and IOP
Moderators: Jeffrey W. Kiel and Claudio Bucolo
1969 — C0183 A Role for Myocilin in Receptor
Endocytosis. Brian S. McKay1, N. R. Congrove1,
W. M. Dismuke2, W. Stamer2. 1Ophthalmology and
Vision Science, University of Arizona, Tucson, AZ;
2
Ophthalmology, Duke University, Durham, NC
*CR
1970 — C0184 Differential Comparison of
Aqueous Humor Phosphatidylcholines from
Control and Glaucomatous Donors. Ayman
Aljohani, Y. C. Guerra, M. C. Piqueras, R. K. Lee,
S. K. Bhattacharya. Bascom Palmer Eye Institute,
University of Miami, Miami, FL *CR
1971 — C0185 Ocular Hypertension-Induced
MMPs Production Within Optic Nerve: A
Regulatory Role of δ-Opioid-Receptors. Sudha
Singh, M. F. Pathan, N. Akhter, M. Nix, S. Husain.
Ophthalmology, Medical University of South
Carolina, Charleston, SC
1972 — C0186 Requirement for the
proteasome, ATP and exportin-1 in the nuclear
export of glucocorticoid alpha (GRα) receptor
following DEX treatment in human trabecular
meshwork cell-line (NTM5). Adnan Dibas1, 2,
A. F. Clark3, 2, T. Yorio1, 2. 1Pharmacology &
Neuroscience, University of North Texas Hlth Sci
Ctr, Fort Worth, TX; 2North Texas Eye Research
Institute, Fort Worth, TX; 3Cell Biology and
Anatomy, Univertsity of North Texas Health
Science Center at Fort Worth, Fort Worth, TX *CR
1973 — C0187 Non-invasive Intraocular
Pressure Measurements in Zebrafish. D Joshua
Cameron, P. G. Davey. College of Optometry,
Western University of Health Sciences, Pomona,
CA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
151
Monday Posters
11:00 am – 12:45 pm
1950 — C0164 Recurrence of macular edema
after intravitreal bevacizumab injection in
eyes with macular edema secondary to retinal
vein occlusion. Young Gyun Kim1, J. Moon1, K.
Seo2, S. Lee3, E. Kim3, S. Yu2, H. Kwak2. 1Eulji
medical center, Seoul, Republic of Korea; 2Kyung
Hee hospital, Seoul, Republic of Korea; 3Eulji
University Hospital, Daejeon, Republic of Korea
1974 – 1997 – Monday – Posters
1974 — C0188 Characterization of TRPV4
expression & function in the ciliary body &
trabecular meshwork. Amber M. Frye1, D. A.
Ryskamp1, 2, P. Barabas1, T. Molnar1, D. Krizaj1, 2.
1
Ophthalmology & Visual Sciences, Moran Eye
Institute, University of Utah School of Medicine,
Salt Lake City, UT; 2Interdepartmental Program in
Neuroscience, University of Utah, Salt Lake City,
UT
Monday Posters
11:00 am – 12:45 pm
1975 — C0189 Ocular Hypertension-Induced
Changes in the Anterior Segment of Cynomolgus
Monkeys. Shenouda Yacoub, Q. Sessums, B. H.
Li, G. Prasanna. Glaucoma Research, NIBROphthalmology, Fort Worth, TX *CR
1976 — C0190 Regulation of Mammalian
Sympathetic Neurotransmitter Release and
Intraocular Pressure by Hydrogen Sulfide Donor,
GYY 4137. Ankita Salvi1, P. Bankhele1, J. Jamil1,
Y. Njie-Mbye2, M. S. Kulkarni2, S. E. Ohia2, C. A.
Opere1. 1Creighton University, Omaha, NE; 2Texas
Southern University, Houston, NE
1977 — C0191 Episcleral Venous Pressure
Elevation in Untreated Open Angle Glaucoma.
Arthur J. Sit1, N. Arora1, J. W. McLaren1, M.
Malihi1, 2, L. Voskanyan3. 1Ophthalmology, Mayo
Clinic, Rochester, MN; 2Ophthalmology, University
of Medicine and Dentistry of New Jersey, Newark,
NJ; 3Malayan Ophthalmology Centre, Yerevan,
Armenia *CR
1978 — C0192 Expansion of Schlemm’s Canal
by Travoprost in Healthy Subjects determined
by Fourier-Domain Optical Coherence
Tomography. Junyi Chen1, H. Huang1, S. Zhang1,
X. Chen1, X. Sun1, 2. 1Ophthalmology, Eye & ENT
Hospital of Fudan University, Shanghai, China;
2
State Key Laboratory of Medical Neurobiology,
Institutes of Brain Science, Fudan University,
Shanghai, China f
1979 — C0193 Thinning of RNFL is correlated
with declining of PhNR ERG amplitude in
glaucomatous monkeys. Byron H. Li, N. V.
Rangaswamy, S. Q. Sessums, R. L. Ornberg, G.
Prasanna. NIBR Ophthalmology, Novartis, Fort
Worth, TX *CR
1980 — C0194 In Vivo Agreement of
Intraocular Pressures Simultaneously Measured
Using Tonometer and Manometers Placed in
Anterior and Vitreous Cavity under General
Anesthesia. Hyun Seung Yang, J. Kim. Department
of Ophthalmology, Asan Medical Center, Seoul,
Republic of Korea f
1981 — C0195 Regulatory Roles of
Anoctamin-6 in Human Trabecular Meshwork
Cells. Juni Banerjee1, A. Li1, 3, C. Leung1, K.
Peterson-Yantorno1, W. Stamer4, M. M. Civan1, 2.
1
Physiology, Univ of Pennsylvania Perelman Sch
of Med, Philadelphia, PA; 2Medicine, Univ of
Pennsylvania Perelman Sch of Med, Philadelphia,
PA; 3Anatomy, University of Hong Kong- (LKS)
Faculty of Medicine, Hong Kong SAR, China;
4
Ophthalmology, Duke University, Durham, NC
*CR
1982 — C0196 Aqueous Humor Dynamics
of the Water Drinking Test in Healthy
Individuals. Nitika Arora1, J. W. McLaren2, A.
J. Sit2. 1Ophthalmology, Mayo Sch of Grad Med
Education, Rochester, MN; 2Ophthalmology, Mayo
clinic, Rochester, MN *CR
1983 — C0197 Foreign-body-reaction-induced
chronic ocular hypertension in rat. Bing Li1, Y.
Wang2, S. Cao2, O. Kraszewska2, R. Ornberg2, G.
Prasanna1. 1Glaucoma Research, NIBR, Novartis,
Fort Worth, TX; 2Retina Research, NIBR, Novartis,
Fort Worth, TX *CR
1984 — C0198 Effect of the Water Drinking
Test in Subjects with Pure Autonomic Failure
and Normal Tension Glaucoma. William M.
Watkins1, D. Robertson2, K. M. Joos1. 1Vanderbilt
Eye Institute, Vanderbilt University Medical Center,
Nashville, TN; 2Clinical Pharmacology Division/
Medicine, Vanderbilt University Medical Center,
Nashville, TN *CR, f
1985 — C0199 Suction-cup oculopression offers
minimal-invasive opportunities of arbitrary
IOP elevations in rats. Theresa Lueckner, O. W.
Gramlich, M. Kriechbaum, J. Teister, N. Pfeiffer, F.
H. Grus. Department of Ophthalmology, University
Medical Center, Experimental Ophthalmology,
Mainz, Germany *CR
1986 — C0200 Comparative IOP lowering
from single dose studies of latanoprost, timolol
and ONO-9054 in Dogs and Monkeys. Kazufumi
Nagai, S. Yamane, K. Moriyuki, T. Karakawa, S.
Nakao, T. Shiroya, Y. Shichino. Ono Pharmaceutical
Co., LTD, Osaka, Japan *CR
1987 — C0201 Baicalein Lowers Intraocular
Pressure in Gerbils. Chi-wai W. Do1, C. T.
Leung1, H. Chan1, M. M. Civan2, C. To1. 1School
of Optometry, The Hong Kong Polytechnic
University, Hong Kong, Hong Kong; 2Department
of Physiology, University of Pennsylvania,
Philadelphia, PA
1988 — C0202 Definition of Normal
Ophthalmic Measures in the African Green
Monkey. Robin J. Goody, W. Hu, S. D. Whittaker,
S. T. Henry, R. Brookes, M. J. Struharik, E.
Hechanova, M. S. Lawrence. RxGen, Inc, Hamden,
CT *CR
1989 — C0203 BK2A77: A novel non-peptide
bradykinin B2 agonist lowers intraocular
pressure in ocular hypertensive cynomolgus
monkeys. Ganesh Prasanna1, N. Sharif1, B. H.
Li1, C. Kelly1, S. Xu1, L. Li1, D. Scott1, R. Daly1,
M. Hellberg2, K. Combrink2. 1Glaucoma Research,
Novartis Institute of Biomedical Research (NIBR)
Ft. Worth/Alcon Research Ltd, Fort Worth, TX;
2
Global Discovery Chemistry, Novartis Institute
of Biomedical Research (NIBR) Ft Worth/Alcon
Research Ltd, Fort Worth, TX *CR
1990 — C0204 Evaluation of Changes in
Intraocular Pressure Immediately After
Intravitreal Injection of Anti-VEGF Medication.
Julio C. Chora, V. H. Gonzalez. 19204, Valley
Retina Institute, McAllen, TX *CR
1991 — C0205 Efficacy and safety of Polyquadpreserved Travoprost in Ocular Hypertensives
and Open Angle Glaucoma patients: an open
label, observational, 6-month, switch study.
Teresa Rolle1, R. Penna1, A. G. Actis1, L. Scudeller3,
G. Pasinetti4, G. C. Rossi2. 1Clin PhysiopatholSection of Opht, University of Torino, Torino, Italy;
2
Eye Clinic, University of Pavia, IRCCS Policlinico
San Matteo Foundation, University of Pavia, Pavia,
Italy; 3Clinical Epidemiology and Biometric Unit,
Scientific Direction, IRCCS Policlinico San Matteo
Foundation, University of Pavia, Pavia, Italy; 4Eye
Unit, Istituto Beato Palazzolo, Bergamo, Italy *CR
1992 — C0206 Ocular Hypotensive Activity
Of A New Melatonin Analog OPD-11, In
Normotensive Rabbits. Maria Caballo Gonzalez1,
C. del Campo2, L. Salazar2, V. Andres-Guerrero1,
M. Vicario de la Torre1, R. Herrero-Vanrell1, I. T.
Molina-Martínez1. 1Pharmacy and Pharmaceutical
Technology, Faculty of Pharmacy/Complutense
Univ., Madrid, Spain; 2Pharmaceutical and Organic
Chemistry, Faculty of Pharmacy/Complutense
Univ., Madrid, Spain
1993 — C0207 Comparison of Rebound
Tonometry in Sedated and Non-Sedated Non
Human Primates (NHP). Mark Vezina1, S.
Wise1, K. Tenneson1, M. Bussieres2, T. Bryant1,
E. Edwards1. 1Ocular And Neuroscience, Charles
River, Senneville, QC, Canada; 2V&O Services, St.
Lazare, QC, Canada *CR
1994 — C0208 Expression of Circadian
Rhythm Genes in the Mouse Iris-Ciliary Body
Complex. Jeffrey J. Dunmire1, L. Dalvin1, R.
Bouhenni1, D. P. Edward2, 3. 1Ophthalmology,
Summa Health System, Akron, OH;
2
Ophthalmology, King Khaled Eye Specialist
Hospital, Riyadh, Saudi Arabia; 3Ophthalmology,
Wilmer Eye Institute, Johns Hopkins University,
Baltimore, MD
1995 — C0209 Sphingosine-1-Phosphate
signaling in cultured human trabecular
meshwork cells. Sietse T. Braakman1, K. M.
Perkumas2, D. R. Overby1, D. F. Woodward3, W.
Stamer2. 1Bioengineering, Imperial College London,
London, United Kingdom; 2Ophthalmology,
Duke University, Durham, NC; 3Biol Sci RD-2C,
Allergan, Inc, Irvine, CA *CR
1996 — C0210 Shear Stress Stimulation of NO
release from Schlemm’s Canal Cells. Nicole E.
Ashpole1, D. R. Overby2, C. R. Ethier3, W. Stamer1, 4.
1
Biomedical Engineering, Duke University,
Durham, NC; 2Biomedical Engineering, Imperial
College, London, United Kingdom; 3Biomedical
Engineering, Georgia Institute of Technology,
Atlanta, GA; 4Ophthalmology, Duke University,
Durham, NC *CR
1997 — C0211 Peptide and Non-Peptide
Bradykinin (BK) Agonists and Antagonists Help
Define Functional BK Receptors in Human
Trabecular Meshwork and Ciliary Body. Naj
Sharif1, P. Katoli1, C. R. Kelly1, L. Li1, S. Xu1,
Y. Wang1, G. Prasanna1, K. D. Combrink1, M.
Hellberg1, S. Husain2. 1Ophthalmology Research,
Alcon Research, Ltd-Novartis Institute of
Biomedical Research (NIBR), Fort Worth, TX;
2
Ophthalmology, Medical University of S. Carolina,
Charlston, SC *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
152
Monday – Posters – 1998 – 2022
1998 — C0212 Effect of ONO-9054 on Aqueous
Humor Dynamics in Monkeys. Tomohiro
Karakawa, S. Yamane, K. Nagai, S. Nakao, T.
Shiroya, Y. Shichino. ONO Pharmaceutical CO.,
LTD, Mishimagun, Japan *CR
1999 — C0213 Cabergoline and IOP:
implications for structure-based drug discovery
of selective dopaminergic ligands. Filippo Drago,
C. Platania, G. Marrazzo, G. Leggio, C. Bucolo.
Clinical and Molecular Biomedicine, University of
Catania, Catania, Italy *CR
2000 — C0214 Twenty-four hour Variations in
Ocular Biometric Parameters in Patients with
Ocular Hypertension. Shan Fan, V. Gulati, D. G.
Neely, N. V. Harms, C. B. Toris. Ophthalmology,
Univ of Nebraska Medical Ctr, Omaha, NE *CR, f
2002 — C0216 Effects of Nitric Oxide Donor
on Outflow Facility in Mice. Jason Y. Chang1,
C. M. Marando1, C. R. Ethier1, 2, W. Stamer3, D.
R. Overby1. 1Bioengineering, Imperial College
London, London, United Kingdom; 2Biomedical
Engineering, Georgia Institute of Technology,
Atlanta, GA; 3Ophthalmology, Duke University,
Durham, NC *CR
2003 — C0217 Tracking protein endocytosis
and trafficking to exosomes released from
trabecular meshwork cells. W M. Dismuke1, B. S.
McKay2, A. Khatri1, K. M. Perkumas1, W. Stamer1.
1
Ophthalmology, Duke University, Durham, NC;
2
Ophthalmology, University of Arizona, Tucson,
AZ *CR
2004 — C0218 PEDF Effects on Outflow
Facility. Morgan E. Rogers1, I. Navarro1, K.
M. Perkumas1, R. Allingham1, P. Challa1, C. E.
Crosson2, W. Stamer1. 1Duke University, Durham,
NC; 2Medical University of South Carolina,
Charleston, SC *CR
2005 — C0219 Ocular hypertensive effect of
pilocarpine in the anesthetized rat. Jeffrey W.
Kiel, A. L. Maldonado. Ophthalmology, Univ of
Texas Hlth Sci Ctr SA, San Antonio, TX
2006 — C0220 Poly-Unsaturated Fatty
Acids in Human Aqueous Humor. Jonathan D.
Nussdorf1, 2, J. Manalac1, Y. Lu3, S. Hong3, N. G.
Bazan3. 1Department of Ophthalmology, Ochsner
Clinic Foundation, New Orleans, LA; 2University
of Queensland School of Medicine, Brisbane, QLD,
Australia; 3Neuroscience Center, Louisiana State
University Health Science Center, New Orleans, LA
Monday, May 06, 2013 11:00 AM-12:45 PM
Biochemistry/Molecular Biology
257 Retina/RPE: Molecular and
Cell Biology
Moderators: Gianluca Tosini and
Monte A. Del Monte
2007 — D0038 Characterization of Chicken
Retinal Horizontal Cell Primary Cultures.
Mario E. Guido, L. P. Morera, N. Díaz. Biological
Chemistry, CIQUIBIC-Conicet, Facultad de
Ciencias Quimicas UNC, Cordoba, Argentina
2008 — D0039 Effect of prostaglandin E2 on
collagen gel contraction in mouse retinal pigment
epithelium cells. Tomoko Orita, K. Kimura, K.
Sonoda. Ophthalmology, Yamaguchi University,
Ube, Japan
2009 — D0040 Age-dependent Biochemical
Changes in the Retina of Glutaredoxin 2 (Grx2)
Knockout Mice. Hongli Wu1, M. F. Lou1, 2. 1VBS,
University of Nebraska-Lincoln, Lincoln, NE;
2
Redox Biology Center, University of NebraskaLincoln, Lincoln, NE
2015 — D0046 Spatial Analysis of
Morphometry of Retinal Pigment Epithelium
in the Normal Human Eye. Alia Rashid1, 2, S. K.
Arora2, M. A. Chrenek2, S. Park2, Q. Zhang1, J. M.
Nickerson2, H. E. Grossniklaus1, 2. 1Department of
Ocular Oncology and Pathology, Emory University
School of Medicine, Atlanta, GA; 2Department
of Ophthalmology, Emory University School of
Medicine, Atlanta, GA
2016 — D0047 AMP-activated Protein
Kinase Suppresses Matrix Metalloproteinase-9
Expression and Cell Migration of Mouse
Retinal Pigment Epithelium. Yuki Morizane1, 2, K.
Takeuchi1, J. Suzuki1, T. Yoshimura1, Y. Murakami1,
M. Kayama1, F. Kumase1, B. Viollet3, J. W.
Miller1, D. Vavvas1. 1Retina Service, Angiogenesis
Laboratory, Massachusetts Eye and Ear Infirmary,
Boston, MA; 2Ophthalmology, Okayama University
Graduate School of Medicine, Dentistry and
Pharmaceutical Sciences, Okayama, Japan;
3
INSERM, Paris, France *CR
2017 — D0048 Identification of genes critical
for normal pigmentation of RPE and crossing of
the optic nerves in mouse embryos. Sonia Guha1,
A. Young1, D. B. Farber1, 2. 1Ophthalmology, Jules
Stein Eye Institute - UCLA, Los Angeles, CA;
2
Molecular Biology Institute, UCLA, Los Angeles,
CA
2010 — D0041 Role of Hypoxia-inducible
Factor 1 Alpha in Hydrogen Peroxide-induced
Human Retinal Pigment Epithelial Cell Death.
Piyush C. Kothary, P. Lee, N. B. Parikh, S.
Abraham, M. A. Del Monte. Ophthalmology, Univ
of Michigan-Kellogg Eye Ctr, Ann Arbor, MI
2018 — D0049 Rosemary extract and its
effects on retinal gene expression with and
without photic challenge. Alison Ziesel1, D. T.
Organisciak3, R. Darrow3, C. Rapp3, J. C. Lang2, P.
Wong1. 1Emory University, Atlanta, GA; 2University
of Texas at Arlington, Cedar Hill, TX; 3Wright State
University, Dayton, OH *CR
2011 — D0042 Extremely brief lightpreconditioning in pigmented mouse model
of light-induced retinal degeneration (LIRD).
Priscila P. Cunha, M. A. Chrenek, J. T. Sellers, J.
H. Boatright. Ophthalmology, Emory University
School of Medicine, Atlanta, GA
2019 — D0050 Dopamine Entrains
The Circadaian Rhythm of PER2::LUC
Bioluminescence in The Mouse Retinal Pigment
Epithelium. Kenkichi Baba, S. ContrerasAlcantara, G. Tosini. Morehouse School of
Medicine, Atlanta, GA
2012 — D0043 TGF-beta2 promotes RPE
cell invasion into collagen gel by mediating
urokinase-type plasminogen activator (uPA)
expression. Koji Sugioka1, A. Kodama1, K.
Yoshida2, K. Okada3, S. Kusaka4, C. Matsumoto1,
Y. Shimomura1. 1Ophthalmology, Kinki University
Faculty of Medicine, Osakasayama, Japan;
2
Biochemistry, Kinki University Faculty of
Medicine, Osakasayama, Japan; 3Physiology and
Regenerative Medicine, Kinki University Faculty of
Medicine, Osakasayama, Japan; 4Ophthalmology,
Sakai Hospital, Kinki University Faculty of
Medicine, Sakai, Japan
2020 — D0051 The transcription factor neural
retina leucine zipper controls photoreceptorspecific expression of Reep6. Hong Hao1, S.
Veleri1, B. Sun1, R. Sood2, P. Liu2, A. Swaroop1.
1
Neurobiol, Neurodegnrtn & Rpr Lab, National Eye
Institute, Bethesda, MD; 2National Human Genome
Research Institute, Bethesda, MD
2013 — D0044 Light induced retinal damage
in 129sv pigmented mice. Micah A. Chrenek, J. T.
Sellers, S. L. Foster, D. R. Zuelke, T. L. Liao, J. M.
Nickerson, J. H. Boatright. Ophthalmology, Emory
University, Atlanta, GA
2022 — D0053 Characterization of Age
Related Maculopathy Susceptibility 2 (ARMS2)
transcripts in human and Cynomolgus macaque
retina. Peng Yu, D. Donohue, K. L. Rhoades,
C. Romano, R. V. Patil. Opthalmology, Novartis
Institutes for Biomedical Research, Alcon Research
Ltd., Fort Worth, TX *CR
2014 — D0045 Analysis of Human Retinal
Pigment Epithelium (RPE) Morphometry in
the Macula of the Normal Aging Eye. Shagun
K. Arora, A. Rashid, M. A. Chrenek, Q. Zhang,
S. Park, H. E. Grossniklaus, J. M. Nickerson.
Ophthalmology, Emory University School of
Medicine, Atlanta, GA
2021 — D0052 Elucidating the mechanism
behind enhanced retinal transduction of an
AAV2 variant. Kenton T. Woodard, R. Samulski.
Gene Therapy, Neurobiology, Univ of NC at Chapel
Hill, Chapel Hill, NC *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
153
Monday Posters
11:00 am – 12:45 pm
2001 — C0215 Voltage-coupled single-needle
constant-pressure anterior chamber perfusion
in live mice. MinHee K. Ko1, A. Yelenskiy2, J. M.
Gonzalez1, J. C. Tan1. 1Ophthalmology, University
of Southern California, Los Angeles, CA; 2School
of Medicine, University of Wisconsin, Madison, WI
Exhibit Hall D0038-D0054
2023 – 2043 – Monday – Posters
2023 — D0054 Generation of GARP2-Specific
Knockout Mice Using Zinc Finger Nuclease
Technology. Steven J. Pittler1, D. Davis1, L. W.
Johnson2, R. A. Kesterson2. 1Vision Sciences, Univ
of Alabama at Birmingham, Birmingham, AL;
2
Genetics Research Division, Univ of Alabama at
Birmingham, Birmingham, AL
Exhibit Hall D0163-D0191
Monday, May 06, 2013 11:00 AM-12:45 PM
Immunology/Microbiology
Monday Posters
11:00 am – 12:45 pm
258 Immune Responses and
Immunopathology
Moderators: Johannes Schwartzkopff and
Sharmila Masli
2024 — D0163 IL-2/IL-2 Ab complex plus
rapamycin ameliorate experimental autoimmune
uveoretinitis associated with expansion of
CD4+Foxp3+ regulatory T cells. Hiroshi Keino,
Y. Sato, A. A. Okada. Ophthalmology, Kyorin
University, Mitaka, Japan *CR
2025 — D0164 T-cell and cytokine
investigations in an experimental model of
retinal ganglion cell loss. Sandra Kuehn, R.
Noristani, M. Kuehn, B. H. Dick, S. C. Joachim.
Experimental Eye Resch Inst, Ruhr University
Bochum, Bochum, Germany
2026 — D0165 Altered CD8+ T cell function
in human non-infectious uveitis. Sima Hirani1,
P. Chen1, S. Jawad1, I. A. Thompson1, B. Liu1, L.
Wei1, H. Sen1, R. W. Lee2, R. B. Nussenblatt1. 1NEI,
NIH, Bethesda, MD; 2School of clinical sciences,
University of Bristol, Bristol, United Kingdom *CR
2027 — D0166 The contribution of T cells to
retinopathy of prematurity in mice. Dean Talia,
T. Zhu, A. Agrotis, R. M. Slattery, M. Le Page, F.
Mackay-Fisson, J. L. Wilkinson-Berka. Monash
University, Melbourne, VIC, Australia *CR
2028 — D0167 Fas-dependent release of
high-mobility group protein B1 (HMGB1)
in the eye is critical for the development of
experimental autoimmune uveitis (EAU)
initiated by uveitogenic T cells. Guomin Jiang, A.
R. Hajrasouliha, H. J. Kaplan, H. Shao. Department
of Ophthalmology, University of Louisville,
Louisville, KY
2031 — D0170 Investigating the response of
naive T-cells to the three isoforms of TGFβ.
Robert J. Barry1, 2, D. Withers3, P. I. Murray1, 2,
P. J. Lane3, J. Curnow1, 2. 1Academic Unit of
Ophthalmology, University of Birmingham,
Birmingham, United Kingdom; 2Centre for
Translational Inflammation Research, University
of Birmingham, Birmingham, United Kingdom;
3
Institute for Biomedical Research, University of
Birmingham, Birmingham, United Kingdom
2032 — D0171 V-domain Ig Suppressor of T
Cell Activation (VISTA) is Necessary for Corneal
Allograft Survival. Tomoyuki Kunishige1, H.
Taniguchi1, T. Ohno2, M. Azuma2, J. Hori1. 1Nippon
Medical School, Bunkyoku, Japan; 2Tokyo Medical
and Dental University, Bunkyoku, Japan
2033 — D0172 Leukocyte Infiltrate in Rabbit
Tears Post Intravenous Muramyl Dipeptide.
Marlyn P. Langford, T. W. Plauche, C. Y. Bundrick,
T. B. Redens. Ophthalmology, Lousiana State Univ
Hlth Sci Ctr, Shreveport, LA
2034 — D0173 Dendritic cells from uveitis
patients have a mature phenotype and a reduced
capacity to take up antigen. Ping Chen1, B. Liu1,
R. W. Lee2, H. Sen1, Z. Li1, S. Jawad1, S. Hirani1,
L. Wei1, R. B. Nussenblatt1. 1Lab of Immunology,
National Institute of Health, National Eye Institute,
Rockville, MD; 2Department of Clinical Sciences,
University of Bristol, Bristol, United Kingdom *CR
2035 — D0174 Identifying and classifying
nonspecific orbital inflammation (NSOI) by
gene expression array. James T. Rosenbaum1, 2,
D. Choi3, C. A. Harrington4, G. J. Harris5, C. N.
Czyz6, V. A. White7, E. A. Steele1, B. S. Korn8, D.
J. Wilson1, S. R. Planck1. 1Casey Eye Institute,
Oregon Health & Science University, Portland, OR;
2
Devers Eye Institute, Legacy Research Institute,
Portland, OR; 3Public Health and Preventive
Medicine, Oregon Health & Science University,
Portland, OR; 4Integrated Genomics, Oregon
Health & Science University, Portland, OR;
5
Department of Ophthalmology, Medical College
of Wisconsin, Milwaukee, WI; 6Department of
Ophthalmology, Ohio University, Columbus, OH;
7
Department of Pathology, University of British
Columbia, Vancouver, BC, Canada; 8Department
of Ophthalmology, University of California, San
Diego, CA *CR
2029 — D0168 Regulatory T cell levels
and cytokine production in active noninfectious uveitis: in vitro effect of anti-TNF-α,
dexamethasone, and cyclosporine. Blanca
Molins2, 1, V. Llorens1, M. Mesquida1, L. Pelegrin1,
A. Adan Civera1. 1Ophthalmology, Hospital Clinic
Barcelona, Barcelona, Spain; 2Ophthalmology,
Fundacio Clinic Recerca Biomedica, IDIBAPS,
Barcelona, Spain
2036 — D0175 Association of
Thrombospondin-1 Polymorphism with
Predisposition to Chronic Dry Eye. Laura
Contreras-Ruiz1, B. Turpie1, D. S. Ryan2, R. K. Sia2,
K. S. Bower3, D. A. Dartt4, S. Masli1. 1Department
of Ophthalmology, Boston University School of
Medicine, Boston, MA; 2U.S. Army Warfighter
Refractive Surgery Research Center, Fort Belvoir,
VA; 3The Wilmer Eye Institute, The Johns Hopkins
School of Medicine, Baltimore, MD; 4Schepens
Eye Research Inst and Massachusetts Eye and Ear,
Department of Ophthalmology Harvard Medical
School, Boston, MA
2030 — D0169 Local Regulatory T Cells of the
Retina Protect Against Spontaneous and Induced
Autoimmune Disease. Scott W. McPherson, N. D.
Heuss, M. J. Pierson, D. S. Gregerson. Department
of Ophthalmology and Visual Neurosciences,
University of Minnesota, Minneapolis, MN
2037 — D0176 Expression and Function of the
NLRC4/NAIP5 Inflammasome in the Ocular
Surface: Ramifications of Eicosanoid Storms.
Karsten Gronert, K. M. Hu, D. W. Lin, Y. Wang,
S. B. Wang. Vision Science, School of Optometry,
University of California, Berkeley, Berkeley, CA
2038 — D0177 What Is the Lineage of IL17+IFN-γ+CD4+ T Cells in Dry Eye Disease?
Yihe Chen, S. K. Chauhan, Z. Sadrai, J. Hua, R.
Dana. Schepens Eye Research Ins /MEEI, Boston,
MA *CR
2039 — D0178 Mechanisms involved
in conjunctival immunological tolerance
breakdown by eye drop preservatives.
Jeremías G. Galletti1, 2, L. Gabelloni1, F.
Sabbione1, P. Chiaradia2, M. N. Giordano1, J. F.
Casiraghi2. 1Immunology Laboratory, Institute
of Experimental Medicine, National Academy of
Medicine/CONICET, Buenos Aires, Argentina;
2
Ophthalmology, Hospital de Clínicas, University of
Buenos Aires, Buenos Aires, Argentina
2040 — D0179 Gene expression in thyroid eye
disease relative to other orbital diseases. Stephen
R. Planck1, D. Choi2, C. A. Harrington3, C. N.
Czyz4, R. A. Dailey1, P. J. Dolman5, G. J. Harris6,
P. Stauffer1, D. J. Wilson1, J. T. Rosenbaum1, 7.
1
Casey Eye Institute, Oregon Health & Science
University, Portland, OR; 2Public Health and
Preventive Medicine, Oregon Health & Science
University, Portland, OR; 3Integrated Genomics,
Oregon Health & Science University, Portland, OR;
4
Department of Ophthalmology, Ohio University,
Columbus, OH; 5Department of Ophthalmology
and Visual Sciences, University of British
Columbia, Vancouver, BC, Canada; 6Department
of Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 7Devers Eye Institute, Legacy
Research Institute, Portland, OR *CR
2041 — D0180 An optical coherence
tomography based in vivo scoring system for
experimental autoimmune uveoretinitis. Colin
J. Chu1, P. Herrmann1, L. S. Carvalho1, S. E.
Liyanage1, J. W. Bainbridge1, 2, R. R. Ali1, 2, A. D.
Dick3, 2, U. F. Luhmann1. 1Department of Genetics,
UCL Institute of Ophthalmology, London, United
Kingdom; 2NIHR Biomedical Research Center for
Ophthalmology, Moorfields Eye Hospital, London,
United Kingdom; 3Unit of Ophthalmology, School
of Clinical Sciences, University of Bristol, Bristol,
United Kingdom *CR
2042 — D0181 Age related aqueous cytokine
and growth factor changes in cataract patients.
Jing Li, Y. Zheng, Y. Xu, S. Lee, Y. Rao, Q. Zhang, P.
Zhao. Ophthalmology, Xinhua Hospital affiliated to
Shanghai Jiao Tong University School of Medicine,
Shanghai, China
2043 — D0182 The Herpes Simplex Virus-1
Latency-Associated Transcript Promotes
Functional Exhaustion of Virus-Specific CD8+ T
Cells in Trigeminal Ganglia of Latently Infected
“humanized” HLA-transgenic rabbits. Lbachir
BenMohamed, X. Dervillez, H. Qureshi, A. A.
Chentoufi, C. Nguyen, O. R. Diaz, A. B. Nesburn, S.
L. Wechsler. Gavin Herbert Eye Institute, Univ of
California-Irvine, Irvine, CA
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
154
Monday – Posters – 2044 – 2062
2044 — D0183 Two Human Leukocyte Antigen
(HLA)-A*0201-Restricted Epitopes Identified
from Herpes Simplex Virus Glycoprotein B
are Recognized Exclusively by CD8+ T cells
from Asymptomatic Individuals and Protect
Against Ocular Herpes. Anthony B. Nesburn1,
X. Dervillez1, H. Qureshi1, A. A. Chentoufi1, O. R.
Diaz1, J. Sidney2, A. Sette2, M. C. Villacres3, S. L.
Wechsler1, L. BenMohamed1. 1Gavin Herbert Eye
Institute, University of California, Irvine, Irvine,
CA; 2Department of Vaccine Discovery, La Jolla
Institute for Allergy and Immunology, La Jolla,
CA 92037, La Jolla, CA; 3Maternal, Child and
Adolescent Center for Infectious Diseases and
Virology, Keck School of Medicine, University of
Southern California, Los Angeles, CA
2046 — D0185 Chemokine C-C motif ligand
7 as a Costimulatory Signal on Mast Cell
Activation and Motility. Chuan-Hui Kuo1, A.
Collins1, M. Ohbayashi1, S. Ono1, 2. 1Cincinnati
Children’s Hospital Medical Center, Cincinnati,
OH; 2Cincinnati University, Cincinnati, OH
2047 — D0186 Immunomodulatory therapy
and multiple sclerosis-associated uveitis.
Gueorgui T. Markov1, 2, K. Vongpaisarnsin2,
C. Foster2, 3. 1Ophthalmology, University Eye
Hospital ‘’Professor Pashev’’, Sofia, Bulgaria;
2
Massachusetts Eye Research and Surgery
Institution, Cambridge, MA; 3Harvard Medical
School, Boston, MA *CR
2048 — D0187 CD163+ and CD68+ cells in
the adult human eye. Svetlana Cherepanoff1, 2,
E. Hasic1, P. G. McMenamin3, M. C.
Gillies4. 1Anatomical Pathology, Prince of Wales
Hospital, Randwick, NSW, Australia; 2School of
Medical Sciences, University of NSW, Randwick,
NSW, Australia; 3Anatomy and Developmental
Biology, Monash University, Melbourne, VIC,
Australia; 4Save Sight Institute, University of
Sydney, Sydney, NSW, Australia *CR
2049 — D0188 Cytokine Production in the
Endotoxin-Induced Uveitis Model. Abrar
A. Rageh1, M. Jordan2, N. D. Heuss1, D. S.
Gregerson1, D. A. Ferrington1, S. R. Montezuma1.
1
Ophthalmology and Visual Neuroscience,
University of Minnesota, Minneapolis, MN;
2
Medical School, North Dakota University, Grand
Forks, ND
2052 — D0191 Response of uveitis-related
retinal vasculitis to therapy with systemic
infliximab. Pramod K. Sharma1, 2, G. T. Markov3, 1,
C. Foster1, 4. 1Uveitis, Massachusetts Eye Research
and Surgery Institution, Cambridge, MA;
2
Ophthalmology, VSS Medical College, Burla,
Sambalpur, India; 3Ophthalmology, University
Eye Hospital ‘’Professor Pashev’’, Sofia, Bulgaria;
4
Harvard Medical School, Boston, MA *CR
Exhibit Hall D0192-D0245
Monday, May 06, 2013 11:00 AM-12:45 PM
Cornea / Biochemistry/Molecular Biology
259 Corneal Immunology, Allergy,
Neovascularization
Moderators: Pedram Hamrah and Scott J. Robbie
2053 — D0192 CICATRICIAL CHANGES
IN OCULAR PEMPHIGUS. Patricia ChirinosSaldaña, I. Zuñiga-Gonzalez, J. C. HernandezCamarena, A. Navas, T. Ramirez-Luquín, A. RoblesContreras, M. C. Jimenez-Martinez, A. J. RamirezMiranda, E. O. Graue-Hernández. Cornea and
Refractive Surgery, Instituto de Oftalmología Conde
de Valenciana, Mexico DF, Mexico *CR
2054 — D0193 The Effect of Trigeminal
Neurons on the Expression of Maturation
Markers by Bone Marrow-Derived Dendritic
Cells. Sang-Mok Lee, W. Stevenson, K. Katikireddy,
H. Lee, T. H. Dohlman, S. K. Chauhan, J. Hua,
Z. Sadrai, M. Omoto, R. Dana. Schepens Eye
Research Institute, Massachusetts Eye and Ear
Infirmary, Harvard Medical School, Boston, MA
*CR
2055 — D0194 Effect of Interleukin17(IL-17) and IL-17 receptor on ocular surface
inflammation. Ai Yamada, T. Sakimoto, A. Ishimori,
T. Ohnishi, S. Sugaya, M. Sawa. Ophthalmology,
Nihon University School of Medicine, Tokyo, Japan
*CR
2056 — D0195 Host Mesenchymal Stem Cells
Home to Transplanted Cornea and Promote
Allograft Survival. Masahiro Omoto, Y. Jin, S. K.
Chauhan. Schepens Eye Research Institute, Harvard
Medical School, Boston, MA
2050 — D0189 Osteopontin is Expressed
by Microglia and T Cells and Regulated by
STAT3. Chengrong Yu, W. Kam, I. M. Dambuza, B.
Marrero, R. M. Mahdi, C. Egwuagu. Laboratory of
immunology, NEI, Bethesda, MD
2057 — D0196 The Cross-reactivity of
Subsequent Corneal Allografting After
Xenocorneal Transplantation Using
Decellularized Porcine Lamella Against
Allo-antigens in Primates. Hyuk Jin Choi1, 2,
J. Lee2, 3, M. Kim2, 3, W. Wee2, 3, H. Lee3, A. Ko3,
J. Lee4, H. Kang5. 1Ophthalmology, Healthcare
System Gangnam Center, Seoul National
University Hospital, Seoul, Republic of Korea;
2
Ophthalmology, Seoul National University
College of Medicine, Seoul, Republic of Korea;
3
Laboratory of Corneal Regenerative Medicine and
Ocular Immunology, Seoul Artificial Eye Center,
Seoul National University Hospital Biomedical
Research Institute, Seoul, Republic of Korea;
4
Xenotransplantation Research Center, Seoul
National University Hospital, Seoul, Republic of
Korea; 5Laboratory Medicine, Hallym University
College of Medicine, Anyang, Republic of Korea
2058 — D0197 Tear expression profiling
of cytokine, chemokine and soluble receptor
in keratoconus patients. Jeewon Mok, C. Joo.
Catholic Institutes of Visual Science, Catholic Univ
Korea, Seoul, Republic of Korea
2059 — D0198 HC-HA Suppresses
Inflammatory and Immune Responses and
Improves Murine Corneal Allograft Survival.
Hua He1, Y. Tan3, V. L. Perez3, 4, S. C. Tseng1, 2.
1
TissueTech. Inc., Miami, FL; 2Ocular Surface
Center, and Ocular Surface Research Education
Foundation, Miami, FL; 3Department of
Ophthalmology, Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL; 4Department of Microbiology and
Immunology, University of Miami Miller School of
Medicine, Miami, FL *CR
2060 — D0199 Polarization of Antiinflammatory M2 Macrophages by HC-HA
Complex Purified from Amniotic Membrane or
Reconstituted In Vitro. Sean Tighe1, H. He1, S.
Zhang1, S. C. Tseng1, 2. 1Tissue Tech Inc., Miami,
FL; 2Ocular Surface Center and Ocular Surface
Research Education Foundation, Miami, FL *CR
2061 — D0200 In Vivo Administration of
Interleukin-2 Increases Corneal Allograft
Survival through Expansion of CD4+CD25+
T Regulatory Cells. Maryam Tahvildari, P.
Emami-Naeini, Y. Chen, M. Omoto, J. Hua, S.
K. Chauhan, R. Dana. Schepens Eye Research
Institute, Massachusetts Eye and Ear, Department of
Ophthalmology, Harvard Medical School, Boston,
MA *CR
2062 — D0201 Proteomic Analysis of Plasma
and Mucosal Samples from Patients with
Stevens-Johnson Syndrome/Toxic Epidermal
Necrolysis. Julia Malalis1, C. Mata1, D. Kahn3, A.
Lin1, M. J. Mosier2, C. S. Bouchard1, J. Cunanan3,
O. Iqbal1, 3, D. Hoppensteadt3, J. Fareed3.
1
Ophthalmology, Loyola University Chicago Stritch
School of Medicine, Maywood, IL; 2Surgery,
Loyola University Medical Center, Maywood, IL;
3
Pathology, Loyola University Chicago Stritch
School of Medicine, Maywood, IL
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
155
Monday Posters
11:00 am – 12:45 pm
2045 — D0184 The Role of Endogenous TLR4
Ligand S100A8/A9 in Ocular Inflammation.
Christina Metea1, J. Ensign-Lewis1, A. Amram1, H.
L. Rosenzweig1, 2, T. Vogl3, J. Roth3, S. R. Planck1,
J. T. Rosenbaum1, 4. 1Casey Eye Institute, Oregon
Health & Science University, Portland, OR;
2
Department of Rheumatology, VA Medical Center,
Portland, OR; 3Institute of Immunology, University
of Münster, Münster, Germany; 4Devers Eye
Institute, Portland, OR *CR
2051 — D0190 Cataract and uveitis:
Comparison of two different anti inflammatory
regimens for the prevention of post-operative
complications. Nathalie Butel1, 2, E. Champion1, V.
Touitou1, C. Fardeau1, B. Bodaghi1, P. Le Hoang1.
1
pitie salpetriere hospital, paris, France; 2Foch
hospital, Suresnes, France *CR
2063 – 2086 – Monday – Posters
Monday Posters
11:00 am – 12:45 pm
2063 — D0202 Morphologic Dendritic
Immune Cells Parameters Reveal Differential
Characteristics between the Central and
Peripheral Cornea: an In Vivo Confocal
Microscopy Normative Data. Clara M. Colon1,
B. M. Cavalcanti1, 2, S. Aggarwal1, A. Cruzat1, 2, C.
Williams1, D. Critser4, A. Watts3, C. W. Sindt4, P.
Hamrah1, 2. 1Department of Ophthalmology, Ocular
Surface Imaging Center, Massachusetts Eye &
Ear Infirmary, Harvard Medical School, Boston,
MA; 2Department of Ophthalmology, Cornea and
Refractive Surgery Service, Massachusetts Eye &
Ear Infirmary, Harvard Medical School, Boston,
MA; 3Contact Lens Service, Massachusetts Eye &
Ear Infirmary, Harvard Medical School, Boston,
MA; 4Department of Ophthalmology & Visual
Sciences, Contact Lens Service, University of Iowa,
Iowa City, IA *CR, f
2064 — D0203 Antimicrobial peptides protect
the corneas from bacteria and fungi infection.
Chen Dong, C. Dong, N. Gao, G. Yoon, F. X. Yu.
Kresge eye institute, Detroit, MI
2065 — D0204 Effect of hydroxychloroquine
on the inflammation in antigen presenting cells
interacted with damaged corneal epithelial
cells. Chang Ho Yoon1, 2, J. Ryu2, M. Kim1, 2, W.
Wee1, 2. 1Ophthalmology, Seoul National University
Hostpital, Seoul, Republic of Korea; 2Laboraory
of Corneal Regenerative Medicine and Ocular
Immunology, Seoul Artificial Eye Center, Seoul
National University Hospital Clinical Research
Institute, Seoul, Republic of Korea
2066 — D0205 Reduced expression of IL17
following rejection in baby rat keratoplasty.
Antonia Hildebrand, T. Reinhard, J. Schwartzkopff.
Ophtalmology, Universitätsklinik Freiburg,
Freiburg, Germany
2067 — D0206 Vitamin D3 attenuates
Toll-like receptor 3 induced inflammation in
human corneal epithelial cells. Rose Y. Reins,
A. M. McDermott. College of Optometry, Univ of
Houston, Houston, TX
2068 — D0207 HC-HA Complex Purified from
Amniotic Membrane Exerts Anti-scarring Effect
by Suppressing TGFβ1 but Activating TGFβ3
Signaling in Human Corneal Fibroblasts. Fu Li2,
Y. Zhu2, H. He2, S. Zhang2, S. C. Tseng1. 1Ocular
Surface Research & Education Foundation, Miami,
FL; 2Tissue Tech Inc., Miami, FL *CR
2069 — D0208 The response of tear film
neutrophils to occasional overnight lens wear.
Maud Gorbet1, 2, D. Luensmann2, L. W. Jones2.
1
Systems Design Engineering, University of
Waterloo, Waterloo, ON, Canada; 2Centre for
Contact Lens Research - School of Optometry,
University of Waterloo, Waterloo, ON, Canada
*CR, f
2070 — D0209 TLR3, RIG-1 and MDA5 are
constitutively expressed on human corneal
limbal fibroblasts and induce proinflammatory
response. Alfredo Domínguez1, 2, R. Bolanos1,
J. Serafín2, J. Nieves-Hernández1, Y. Garfias1, 3.
1
Instituto de Oftalmología Conde de Valenciana,
Mexico City, Mexico; 2Department of Immunology,
National School of Biological Sciences, Instituto
Politécnico Nacional, Mexico City, Mexico;
3
Department of Biochemistry, Faculty of Medicine,
Universidad Nacional Autónoma de México,
Mexico City, Mexico *CR
2071 — D0210 Bilateral Up-regulation of
Limbal Intravascular Adhesion Molecules
Mediates Cell Infiltration into the Cornea after
Unilateral Trigeminal Nerve Axotomy. Deshea
L. Harris1, 2, T. Yamaguchi2, 1, A. Turhan2, U. von
Andrian3, P. Hamrah2, 1. 1Ophthal-Harvard Med
School, Schepens Eye Research Inst, Boston, MA;
2
Ophthal-Harvard Med School, Massachusetts
Eye and Ear Infirmary, Boston, MA; 3Program
in Cellular and Molecular Medicine-Children’s
Hospital Boston, Immune Disease Institute, Boston,
MA
2072 — D0211 Tear Molecule Levels and
Conjunctival Inflammatory Gene Expression
in Atopic Keratoconjunctivitis (AKC). Amalia
Enriquez-De-Salamanca1, 2, E. Trias1, V. MartinezTottil1, L. Cocho1, C. García-Vázquez1, M. J.
Gonzalez-Garcia1, 2, M. Calonge1, 2. 1Ocular Surface
Group, IOBA-University of Valladolid, Valladolid,
Spain; 2Biomedical Research Networking center in
Bioengineering, Biomaterials and Nanomedicine
(CIBER-BBN), Valladolid, Spain *CR
2073 — D0212 Measurement of wheat-specific
tear IgE in patients with allergic conjunctivitis.
Tatsuya Mimura. Department of Ophthalmology,
Tokyo Women’s Medical University Med. Cent.
East, Arakawa-ku, Japan f
2074 — D0213 In vitro toxicity of omalizumab
in conjuctival epithelial cells. Anne-Sophie
Benischke1, A. Neutzner1, 3, C. Tappeiner2, D.
Goldblum3. 1Department for Biomedicine,
University Basel, Basel, Switzerland; 2Department
of Ophthalmology, University Hospital of Bern,
Bern, Switzerland; 3Department of Ophthalomology,
University Basel, Basel, Switzerland
2075 — D0214 Effects of IL-13 Stimulation
on Primary Mouse Conjunctival Epithelial
Cultures. Johanna Tukler Henriksson, X.
Zhang, D. Li, C. S. De Paiva, S. C. Pflugfelder.
Ophthalmology, Baylor College of Medicine,
Houston, TX *CR
2076 — D0215 Increased proliferation of
cultured conjunctival epithelium in IFN-γ
deficient strains. Meng Chen, T. G. Coursey, J.
Tukler Henriksson, C. S. De Paiva, D. Li, S. C.
Pflugfelder. Ophthalmology, Baylor College of
Medicine, Houston, TX *CR
2077 — D0216 Detection of natural helper
cells in innate immune system-dependent
mouse conjunctivitis model. Yosuke Asada1, 2, A.
Matsuda1, K. Hori1, S. Iwamoto1, N. Ebihara1, S.
Nakae2, A. Murakami1. 1Ophthalmology, Juntendo
University School of Medicine, Tokyo, Japan;
2
Frontier Research Initiative, Institute of Medical
Science, University of Tokyo, Tokyo, Japan *CR
2078 — D0217 The Synergistic Effects between
Bevacizumab and Cyclosporin A (Cys A) reduced
the MMP-3 and MMP-13 Expression and the
Migration on Cultured Pterygial Fibroblast
Cells and Tissues. Yeoun-Hee Kim1, 2, Y. Park1, S.
Kang2, J. Jung2, K. Lee1. 1Ophthalmology, Cheil
Eye Hospital, Daegu, Republic of Korea; 2Biology,
Kyungpook National University, Daegu, Republic
of Korea
2079 — D0218 Topical Cyclosporine A
for the Management of Chronic Follicular
Conjunctivitis. Natasha V. Nayak1, A. M.
Kolomeyer1, J. S. Kim2, E. S. Kim2, C. Fang1, D.
S. Chu1, 2. 1Institute of Ophthalmology and Visual
Science, University of Medicine and Dentistry of
NJ, Newark, NJ; 2Metropolitan Eye Research &
Surgery Institute, Palisades Park, NJ *CR
2080 — D0219 Suppression of TLR3-Inducible
Gene Expression by EP3 in Conjunctival
Epithelium. Mayumi Ueta1, 2, S. Narumiya3, S.
Kinoshita1. 1Ophthalmology, Kyoto Prefectural
Univ of Medicine, kyoto, Japan; 2Research Center
for Inflammation and Regenerative Medicine,
Faculty of Life and Medical Sciences, Doshisha
University, kyotanabe, Japan; 3Department of
Pharmacology and Faculty of Medicine, Kyoto
University, kyoto, Japan *CR
2081 — D0220 Model of allergic
keratoconjunctivitis - Stat6 signaling in chronic
inflammation. Michael Conwell1, S. DaSilvaArnold2, N. Luo1, W. Li3, J. Travers2, Y. Sun1, 2.
1
Ophthalmology, Glick Eye Institute, Indianapolis,
IN; 2Dermatology, Indiana University, Indianapolis,
IN; 3Xiamen Eye Institute, Xiamen University,
Xiamen, China *CR
2082 — D0221 Molecular mechanism of
corneal neovascularization inhibition by decorin
therapy. Ashish Tandon, A. Sharma, J. T. Rodier,
R. R. Mohan. Ophthalmology, Mason Eye Institute,
Columbia, MO
2083 — D0222 Recurrent corneal inflammation
stimulates lymphatic vessel memory. Richard M.
Tempero, A. L. Conner, P. M. Kelley. Boys Town
National Rsch Hosp, Omaha, NE
2084 — D0223 The Effects and Underlying
Mechanism of Bevacizumab (Avastin) in
Inhibiting Corneal Neovascularization in a
Rabbit Closed Eye Contact Lens Wear Model.
Wei-Li Chen1, Y. Chen1, 2, F. Hu1. 1Ophthalmology,
National Taiwan University Hospital, Taipei,
Taiwan; 2Ophthalmology, E-Da University Hospital,
Kaohsiung, Taiwan
2085 — D0224 SAMHD1 is a Novel Regulator
of Soluble Flt-1. Leah Owen, D. G. Holt, H.
Uehara, B. K. Ambati. Ophthalmology, University
of Utah John Moran Eye Center, Salt Lake City, UT
2086 — D0225 Serum eye drops promote
vascular endothelial cell proliferation in
vitro and antagonize (antiangiogenic) VEGF
blockade in vivo. Deniz Hos, K. R. Koch, F.
Bock, C. Cursiefen, L. M. Heindl. Department of
Ophthalmology, University of Cologne, Cologne,
Germany *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
156
Monday – Posters – 2087 – 2111
2087 — D0226 Sterculic Acid Antagonizes
7-ketocholesterol-mediated Corneal
Angiogenesis. Joshua Chou, J. Amaral, J. W. Lee,
I. R. Rodriguez. Lab of Retinal Cell & Molecular,
NEI, Bethesda, MD
2088 — D0227 Role of IL-7 in Corneal
Lymphangiogenesis. Tatiana Ecoiffier1, M.
Iolyeva2, C. Halin2, L. Chen1. 1Vision Science,
University of California, Berkeley, School
of Optometry, Center for Eye Disease and
Development, Berkeley, CA, 94720, USA, CA;
2
Institute of Pharmaceutical Sciences, Swiss Federal
Institute of Technology, ETH Zurich, Zurich,
Switzerland
2089 — D0228 Suppression of Corneal
Angiogenesis by Toll-like Receptors. Lei Liu, J.
Wu, A. D. Dick. Dept of Ophthalmology, School
of Clinical Sciences, University of Bristol, Bristol,
United Kingdom *CR
2091 — D0230 Role of Non-Endothelial Cells
in Corneal Angiogenesis. Jin Zhao, T. Nagasaki.
Ophthalmology, Columbia University, New York,
NY
2092 — D0231 Impaired angiogenic response
in cornea by lacking TRPV1 in mice. Katsuo
Tomoyose, Y. Okada, T. Sumioka, K. Shirai, S.
Saika. Wakayama Medical University, Wakayama,
Japan
2093 — D0232 Photodynamic Ablation of
Lymphatic Vessels in the Cornea. Franziska
Bucher1, Y. Bi2, C. Cursiefen1, F. Bock1. 1Department
of Ophthalmology, University of Cologne, Cologne,
Germany; 2Department of Ophthalmology, Tongji
University School of Medicine, Shanghai, China
*CR
2094 — D0233 Formation and Regulation of
Lymphatic Valves during Inflammation. Tan N.
Truong1, E. I. Altiok1, E. Huang1, T. Ecoiffier1, D.
Yuen1, T. Uede2, L. Chen1. 1School of Optometry &
Vision Science, University of California, Berkeley,
Berkeley, CA; 2Division of Molecular Immunology,
Institute for Genetic Medicine, Hokkaido
University, Sapporo, Japan *CR
2095 — D0234 MicroRNA-184 Regulates
Corneal Lymphangiogenesis. Lu Chen, S.
Grimaldo, T. Ecoiffier, D. Yuen. Center for Eye
Disease & Development, Program in Vision Science
and School of Optometry, University of California,
Berkeley, CA
2097 — D0236 Novel Characterization of
MHC-Class II Positive Cells in Embryonic
Cornea during Spontaneous Lymphatic Events.
Don Yuen, G. Li, L. Chen. Center for Eye Disease
and Development, Program in Vision Science and
School of Optometry, University of California,
Berkeley, CA
2105 — D0244 Corneal Organ Culture
Angiogenesis Model. Sally S. Twining, H. Zhang,
D. J. Warejcka. Biochemistry and Ophthalmology,
Medical College of Wisconsin, Milwaukee, WI
2106 — D0245 UV-Crosslinking for Fixation
of Biosynthetic Corneal Collagen Implants.
Kerstin M. Wand1, K. Kobuch1, M. Baumann3, M.
Griffith2, M. M. Islam2, J. Junger3, R. T. Neuhann1,
C. Lohmann1. 1Ophthalmology, Klinikum rechts
der Isar, Technische Universität München, Munich,
Germany; 2Regenerative Medicine, Linkoping
University, Linkoping, Sweden; 3MLase AG,
Germering München, Germany *CR
Exhibit Hall D0334-D0357
2098 — D0237 Deletion of Foxc1 and/or
Foxc2 from neural crest cells leads to corneal
vascularization and anterior segment dysgenesis.
Tsutomu Kume, K. M. Schultz, A. Sasman, S. Seo.
Medicine, Northwestern Univ Sch of Med, Chicago,
IL
Monday, May 06, 2013 11:00 AM-12:45 PM
2099 — D0238 Topical Infliximab as an
inhibitor of corneal hemangiogenesis and
lymphangiogenesis. Giulio Ferrari, F. Bignami,
C. Giacomini, P. Rama. Ophthalmology -Cornea
Unit-Eye Repair, San Raffaele Scientific Institute,
Milan, Italy
Moderator: Shyam S. Chaurasia
2100 — D0239 Effect of LYVE-1 on FGF2induced lymphangiogenesis in vivo. Birgit
Regenfuss1, N. Platonova2, 3, G. Miquel2, 3, S.
Taouji4, E. Chevet4, A. Bikfalvi2, 3, C. Cursiefen1.
1
Ophthalmology, University of Cologne, Cologne,
Germany; 2INSERM U1029, Talence, France;
3
Université Bordeaux I, Talence, France; 4INSERM
U1053, Bordeaux, France *CR
2101 — D0240 Analysis of VEGFR-1 Isoforms
in Pax6-deficient Mice Corneas. Phillip A.
Moore1, P. J. Accola1, B. Artelt1, M. Aarnio1, J.
D. Lauderdale2. 1Dept Small Animal Med/Surg,
College Vet Med Univ Georgia, Athens, GA;
2
Department of Cellular Biology, Franklin College
of Arts and Sciences, The University of Georgia,
Athens, GA
2102 — D0241 Use of Amaranthus leucocarpus
lectin to determine corneal neo-vascularization.
Valeria L. Coria1, 2, G. A. Estua1, A. Domínguez1,
E. Zenteno2, J. Nieves-Hernández1, Y. Garfias1, 2.
1
Research Unit, Institute of Ophthalmology, Mexico
city, Mexico; 2Biochemistry Department, Faculty
of Medicine, Universidad Nacional Autónoma de
México, Mexico city, Mexico *CR
2103 — D0242 Netrin-4 mediates corneal
neovascularization. Anna-Karina Maier, S. V.
Klein, N. Kociok, A. Riechardt, E. Gundlach,
C. Steger, O. Strauss, A. M. Joussen. Charité,
University Medicine Berlin, Berlin, Germany
2104 — D0243 Subconjunctival and
intrastromal Bevacizumab to control of corneal
neovascularization and opacification. Silvia
Mendez, M. Santiago, E. Raposo, R. Touriño, M.
Rodriguez-Ares. Department of Ophthalmology,
University of Santiago de Compostela (USC)
Hospital Complex, Santiago de Compostela, Spain
Cornea
260 Conjunctiva Cell Biology
2107 — D0334 Development of a conjunctival
tissue substitute on the basis of plastic
compressed collagen. Cornelia Corinne
Drechsler1, A. Kureshi2, S. Reichl3, G. Geerling1,
J. T. Daniels2, S. Schrader1. 1Ophthalmology,
University Duesseldorf, Duesseldorf, Germany;
2
Institute of Ophthalmology, UCL - University
College London, London, United Kingdom;
3
Institut für Pharmazeutische Technologie, TU
Braunschweig, Braunschweig, Germany *CR
2108 — D0335 Lymphatic Microvessel Density
as a Predictive Marker for the Recurrence Time
of Pterygium: A 3-year Follow-up Study. Haotian
Lin1, L. Luo1, S. Ling2, W. Chen1, Z. Liu1, X. Zhong1,
C. Wu1, W. Chen1, Y. Liu1. 1State Key Laboratory
of Ophthalmology, Zhongshan Ophthalmic Center,
Guangzhou, China; 2Dept of Ophthalmology, Third
Affiliated Hospital of Sun Yat-sen University,
Guangzhou, China
2109 — D0336 NHE8 Participates in
Electrolyte and Water Secretion in Conjunctival
and Lacrimal Gland Epithelia. Mingwu Wang1,
J. Li2, F. K. Ghishan2, H. Xu2. 1Ophthalmology,
University of Arizona College of Medicine, Tucson,
AZ; 2Pediatrics, University of Arizona College of
Medicine, Tucson, AZ
2110 — D0337 Carboxypeptidase A3
expression in intraepithelial mast cells of chronic
allergic conjunctivitis. Kanji Hori, N. Ebihara,
T. Funaki, K. Ohtomo, Y. Asada, A. Murakami, A.
Matsuda. Ophthalmology, Juntendo Univ School of
Med, Bunkyo-ku, Japan *CR
2111 — D0338 TNFα is required for normal
tissue repair in injured mouse conjunctiva.
Osamu Yamanaka1, A. Kitano1, Y. Okada1, W.
W. Kao2, S. Saika1. 1Ophthalmology, Wakayama
Medical University, Wakayama, Japan;
2
Ophthalmology, University of Cincinnati,
Cincinnati, OH
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
157
Monday Posters
11:00 am – 12:45 pm
2090 — D0229 Subconjunctival Cyclosporine A
implants do not affect corneal neovascularisation
after transplantation: results of a randomized
clinical trial. Claus Cursiefen1, T. Reinhard2, F.
Bock1, H. Prokosch3. 1Dept of Ophthalmology,
University of Cologne, Koln, Germany; 2Dept. of
Ophthalmology, University of Freiburg, Freiburg,
Germany; 3Medical Informatics, University of
Erlangen, Erlangen, Germany *CR, f
2096 — D0235 Live Imaging of Lymphatic
Valve Formation after Corneal Transplantation.
Gyeong Jin Kang1, T. Ecoiffier1, Y. Hong2, L.
Chen1. 1Center for Eye Disease and Development,
Program in Vision Science and School of
Optometry, University of California, Berkeley, CA;
2
Department of Surgery, Norris Comprehensive
Cancer Center, University of Southern California,
Los Angeles, CA
2112 – 2130 – Monday – Posters
2112 — D0339 Substance P is a candidate
for conjunctival epithelial cell derived factors
inducing CCL2 expression in mast cells. Satoshi
Iwamoto1, S. Kawasaki2, Y. Asada1, K. Hori1, A.
Murakami1, N. Ebihara1, A. Matsuda1. 1Juntendo
Univ School of Med, Bunkyoku, Japan; 2Kyoto
Prefectual University, zyoukyoku, Japan *CR
Monday Posters
11:00 am – 12:45 pm
2113 — D0340 Giant Conjunctival Nevus:
Clinical Features and Natural Course in 32
Cases. Phoebe Mellen1, 2, A. C. Regillo1, S. Kaliki1, 3,
S. Lally1, C. L. Shields1, J. Shields1. 1Oncology
Service, Wills Eye Institute, Philadelphia, PA;
2
Jefferson Medical College, Philadelphia, PA;
3
Ocular Oncology Service, L.V. Prasad Eye
Institute, Hyderabad, India
2114 — D0341 Resolvin D1 Receptor Activation
Counter-regulates H1 histamine receptors in
human and rat conjunctival goblet cells. Robin R.
Hodges1, 2, D. Li1, 2, R. B. Carozza1, 2, M. A. Shatos1, 2,
N. Chiang3, 4, C. N. Serhan3, 4, D. A. Dartt1, 2.
1
Schepens Eye Research Institute, Massachusetts
Eye and Ear, Boston, MA; 2Department of
Ophthalmology, Harvard Medical School, Boston,
MA; 3Center Center for Experimental Therapeutics
and Reperfusion Injury, Harvard Institutes of
Medicine, Harvard Medical School, Boston, MA;
4
Department of Anesthesiology, Preoperative, and
Pain Management, Brigham and Women’s Hospital,
Boston, MA *CR
2115 — D0342 Efficacy of rituximab in severe
ocular cicatricial pemphigoid. Serge Doan1, S.
Stephan1, C. Prost2, M. Alexandre2, I. Cochereau1,
E. E. Gabison1. 1Ophthalmology, Bichat Hospital
& A de Rothschild Foundation, Paris, France;
2
Dermatology, Avicenne Hospital, Bobigny, France
*CR
2116 — D0343 Survival with Squamous Cell
Carcinoma of the Conjunctiva in the United
States 1973-2009. Aaron Hendrix1, M. Hendrix2.
1
Georgetown Preparatory School, Bethesda, MD;
2
Rockville Eye Associates, Rockville, MD
2117 — D0344 Effect of Cyclosporin A (Cys A)
to the Matrix Metalloproteinase (MMP)-3 and
MMP-13 on the Migration of Cultured Pterygial
Fibroblast Cells. Young Jeung Park1, Y. Kim1, 2,
S. Lee2, J. Jung2, K. Lee1. 1Ophthalmology, Cheil
eye hospital, Daegu, Republic of Korea; 2Biology,
Kyungpook National University, Daegu, Republic
of Korea
2118 — D0345 Histologic characteristics of
conjunctivochalasis and its correlation with
lymphangiectasis. Woo C. Park, J. Bae, W. Ryu.
of Ophthalmology, College of Medicine, Dong-A
University, Busan, Republic of Korea f
2119 — D0346 Cysteinyl leukotriene receptors
expression in the giant papillae of the chronic
allergic conjunctivitis. Kaori Ohtomo1, N.
Ebihara1, N. Yokoi2, S. Kawasaki2, A. Murakami1,
A. Matsuda1. 1Ophthalmology, Juntendo University
School of Medicine, Tokyo, Japan; 2Ophthalmology,
Kyoto Prefectural University of Medicine, Kyoto,
Japan *CR
2120 — D0347 Constitutive Expression of
PTX3 in HC-HA Complex by Human Amniotic
Membrane Cells. Su-Zhen Zhang1, H. He1, Y. Zhu1,
S. C. Tseng1, 2. 1R&D, TissueTech, Inc, MIAMI, FL;
2
Ocular Surface Center, MIAMI, FL *CR
2121 — D0348 Lymphatic and Blood Vessel
Density in Human Conjunctiva Following
Glaucoma Surgery. Mirela Krasniqi1, H.
Rassavong1, R. Bouhenni1, J. J. Dunmire1, S.
A. Al Shahwan2, I. Al Jadaan2, H. Alkatan2, D.
P. Edward2, 3. 1Ophthalmology, Summa-Health
System, Akron, OH; 2Ophthalmology, King Khaled
Eye Specialist Hospital, Riyadh, Saudi Arabia;
3
Ophthalmology, Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD
2122 — D0349 Molecular Mechanisms of
Inflammatory Apoptosis of Conjunctival
Epithelial Cells and T cells: Effect of Cyclosporin
A (CsA). Jianping Gao1, R. Sana1, V. L. Calder2,
M. Calonge3, W. Lee1, L. A. Wheeler1, M. E. Stern1.
1
Biological Sciences, Allergan, Inc, Irvine, CA;
2
Ocular Biology, Institute of Ophthalmology,
London, United Kingdom; 3Ocular Surface Group,
IOBA-University Of Valladolid, Valladolid, Spain
*CR
2123 — D0350 Immunohistochemical
alterations in cicatricial conjunctivitis associated
with Behcet’s disease. Kazunari Higa1, Y. Satake1,
D. Tomida1, K. Yamazoe2, T. Hayashi3, N. Toriyama1,
J. Shimazaki1. 1Department of Ophthalmology,
Tokyo Dental College, Ichikawa General Hospital,
Ichikawa, Japan; 2Department of Ophthalmology,
Keio University School of Medicine, Shinjuku-ku,
Japan; 3Department of Ophthalmology, Yokosuka
Kyosai Hospital, Yokosuka, Japan *CR
2127 — D0354 Effect of Nerve Growth
Factor on in vitro Human Primary Conjuntival
Epithelial Cell Apoptosis Induced by
Hyperosmolar Stress. Hungwon Tchah, S. Kang, E.
Kim, J. Kim. Department of Ophthalmology, Asan
Medical Center, Seoul, Republic of Korea
2128 — D0355 Use of Evicel as a Fibrin
Adhesive in Pterygium Surgery. Lena Dixit1, 2, T.
R. Shepler2. 1Baylor College of Medicine, Houston,
TX; 2University of Texas Southwestern at Austin,
Austin, TX
2129 — D0356 HLA-DR expression/
mobilization on the conjunctival epithelial cells
exposed to hyperosmolarity and desiccative
stress. Christophe Roubeix1, 2, L. Riancho1, 2, C.
Baudouin1, 3, F. Brignole-Baudouin1, 4. 1Institut de la
Vision, Paris, France; 2INSERM/UPMC Univ Paris
06, Paris, France; 3Quinze-Vingts National Hospital
of Ophthalmology, PARIS, France; 4Paris Descartes
University, Toxicology Department, PARIS, France
*CR
2130 — D0357 Conjunctival
Melanoacanthoma: A New Pigmented
Conjunctival Entity. Saeed F. Al Wadani1, 3, M. J.
Mines1, 2, L. Monroe4, C. Eberhart1. 1Wilmer Eye
Institute, Johns Hopkins University, Baltimore,
MD; 2Dept of Surgery, Ophthalmology Div,
Uniformed Services University, Bethesda, MD;
3
Ophthalmology, King Saud University, Riyadh,
Saudi Arabia; 4Eye and Laser Institute, Boca Raton,
FL
2124 — D0351 Characterization of the Gene
Expression Profile of Conjunctivochalasis.
Stella C. Paparizos1, R. Bouhenni1, J. J. Dunmire1,
T. L. Beyer1, K. K. Abu-Amero2, D. P. Edward3, 4.
1
Ophthalmology, Summa Health System, Akron,
OH; 2Ophthalmology, King Saud University,
Riyadh, Saudi Arabia; 3Ophthalmology, King
Khaled Eye Specialist Hospital, Riyadh, Saudi
Arabia; 4Ophthalmology, Wilmer Eye Institute,
Johns Hopkins University, Baltimore, MD
2125 — D0352 Topical Cyclosporine A for
the Treatment of Chronic Keratoconjunctivitis.
Jason S. Kim1, A. M. Kolomeyer1, C. Fang1, N. V.
Nayak1, E. Kim1, D. S. Chu1, 2. 1New Jersey Medical
School-University of Medicine and Dentistry
of New Jersey, Newark, NJ; 2Metropolitan Eye
Research and Surgery Institute, Palisades Park, NJ
*CR
2126 — D0353 Squamous Metaplasia May
Persist after Pterygium Excision and LimbalConjunctival Autograft. Soo Jeong Ryu1, S. Han3,
H. Yang1, W. Wee2, J. Hyon1. 1Ophthalmology,
Seoul National University Bundang Hospital,
Seongnam-si, Gyeonggi-do, Republic of Korea;
2
Ophthalmology, Seoul National University
Hospital, 101 Daehak-ro Jongno-gu, Seoul 110744, Republic of Korea; 3Ophthalmology, Samsung
Medical Center, 81 Irwon-ro Gangnam-gu, Seoul,
Republic of Korea
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
158
Monday – Workshops/SIGs
TCC LL 4/5
606/607
618-620
Monday, May 06, 2013 1:00 PM-2:30 PM
Monday, May 06, 2013 1:00 PM-2:30 PM
Monday, May 06, 2013 1:00 PM-2:30 PM
Low Vision Group
262 From Stolen Ideas to False
Data: Shining a Light on Scientific
Misconduct
264 Members-in-Training
Career Forum
261 Opportunities and Challenges
for Clinical Trials of Treatment or
Rehabilitation Strategies for
Vision Enhancement
Moderators: Robert W. Massof and Gary S. Rubin
— 1:00 RCTs in Low Vision Rehabilitation:
Lessons Learned from Trials in the UK Hospital
Eye Service. Robert Harper. Manchester Royal Eye
Hospital, Manchester, United Kingdom
Moderators: M Elizabeth Hartnett and
Cynthia Owsley
— 1:00 The Office of Research Integrity:
Institutional Investigations, DIO Oversight, and
Scientific Forensics. John E. Dahlberg. Office of
Research Integrity, HHS, Rockville, MD
This workshop is aimed at helping students, fellows,
residents, and junior faculty prepare for their next
career move. Invited speakers will provide their
perspectives on careers in academia, NIH intramural
laboratories, industry, and non-profit research
institutes. Small-group discussion will be held in
the form of various roundtables focusing on topics
ranging from preparing your CV to negotiating a
startup package. Bring your own lunch.
Moderators: Tonia S. Rex and Jason Porter
— 1:00 Career Development: Weighting the
Merits for the Individual Trainee of Persevering
in Academia - A Program Director’s Perspective.
Laura J. Frishman. College of Optometry,
University of Houston, Houston, TX
— 1:15 Transitioning from Academia to a
Start-up Company. Rafal Farjo. Research and
Development, Charlesson, Oklahoma City, OK *CR
— 1:25 Lessons Learned about Omics-based
Predictive Tests from the Nevins Laboratory at
Duke. Gilbert S. Omenn. Center for Computational
Medicine and Bioinformatics, Ann Arbor, MI *CR
— 1:30 A Personal Perspective for Career
Advancement in Biomedical Research: From
Academia to NIH Intramural Research. Anand
Swaroop. N-NRL, Bldg 6, National Eye Institute,
Bethesda, MD
— 1:50 Inside Scientific Misconduct: Why
Transparency Matters. Adam Marcus. Retraction
Watch, Montclair, NJ
— 1:45 Pursuing a Career in a Pure Research
Environment. Gareth R. Howell. Jackson
Laboratory, Bar Harbor, ME
— 2:15 Discussion
— 2:00 Career Development Roundtables
— 1:54 Opportunities and Challenges:
Mobility-related Outcome Measures. Alexandra
R. Bowers. Ophthal, Harvard Med School, Schepens
Eye Res Inst, Mass Eye and Ear, Boston, MA
611-614
TCC 301/302
Monday, May 06, 2013 1:00 PM-2:30 PM
Monday, May 06, 2013 1:00 PM-2:30 PM
— 2:12 Challenges of Matching Effective
Endpoints to Treatment and Participant Ability.
Ronald A. Schuchard. Rehabilitation R&D /
Neurosurgery, VAPAHCS / Stanford University,
Palo Alto, CA *CR
263 NEI Grants Workshop: All about
Funding Opportunity Announcements
(FOAs)
265 China-ARVO Networking Forum
— 1:18 Difficulties in Designing Clinical Trials:
Recruitment and Retention. Joan Stelmack. VA
Affairs-Bldg 113, Hines VA Hospital, Hines, IL
— 1:36 Outcome Measures: What Constitutes
Success? Hannah M. Dunbar. Visual Neuroscience,
UCL Inst of Ophthalmology, London, United
Kingdom
All applications for NEI funding must be submitted
through a Funding Opportunity Announcement
(FOA). In this grants workshop, NEI staff will
present the whats and whys of FOAs, and point out
how a scientist should read and select one.
Moderator: Lore Anne McNicol
— 1:00 FOAs: What? Ellen S. Liberman. NEI,
NIH, Bethesda, MD
— 1:20 FOAs: Why? Michael A. Steinmetz. NEI,
NIH, Bethesda, MD
— 1:40 FOAs: How to Read Them. Houmam
Araj. NEI, NIH, Rockville, MD
— 2:00 FOAs: How to Choose One. Lore Anne
McNicol. NEI, Bethesda, MD
This is the 8th annual China-ARVO Networking
Forum. The purpose of this event is to provide a
platform for vision researchers from China, the
USA and other countries to interact, discuss and
exchange knowledge in the field of vision research
and ophthalmology and to promote collaboration
among the scientists. Speakers include leading
ophthalmic researchers from China and the USA.
Topics will align with the 2013 ARVO ‘Lifechanging Research’ theme that will show how the
researchers’ innovations benefit people’s lives who
are suffering from major blinding eye diseases.
Everyone is welcome to attend the meeting; a
limited lunch will be provided.
Moderators: David R. Hinton, Kanxing Zhao and
Chi-Chao Chan
— 2:20 Discussion
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
159
Monday Workshops/SIGs
1:00 pm – 2:30 pm
Clinical trials are essential in establishing the
efficacy of new and existing treatments and
rehabilitation strategies for vision enhancement.
However, many challenges may arise in the design
and carrying out of a rigorous clinical trial that
requires long-term follow-up and selection of
meaningful outcome measures appropriate for
both the intervention and subject population.
Opportunities and challenges in this emerging
field will be discussed by a panel of speakers with
extensive experience in conducting clinical trials
with visually impaired individuals.
Several examples of scientific misconduct have
been in the news. This workshop will present what
scientific misconduct constitutes, what process
should be followed if scientific misconduct is
suspected, what means are present to protect
whistleblowers and also explore methods to reduce
misconduct in the future. Examples of misconduct
and of good behavior to reduce the possibility of
fraudulent data are presented. Speakers include
leaders in investigative oversight who have been
involved in the process and science writers of
scientific misconduct.
Monday – Workshops/SIGs
— 1:00 Phenomenon or Hypostasis—
New findings of the potential role of a low
cerebrospinal fluid pressure in Primary Open
Angle Glaucoma and related observations. Ningli
Wang. Ophthalmology, Beijing Tongren Eye Center,
Beijing, China
— 1:10 Epigenetics Modifications in Diabetic
Retinopathy. Renu A. Kowluru. Ophthalmology,
Wayne State Univ/Kresge Eye Inst, Detroit, MI
— 1:20 Polyloidal Choroidal Vasculopathy
in China. Youxin Chen. Department of
Ophthalmology, Peking Union Medical College
Hospital, Beijing, China
Monday Workshops/SIGs
1:00 pm – 2:30 pm
— 1:30 Protective Effects of AREDS2
Formula on a Mouse Model with Focal Retinal
Degeneration. Chi-Chao Chan. Immunopath
Sect, Lab of Immunol, National Eye Institute/NIH,
Bethesda, MD
— 1:40 Targeted Sequencing of 189 Genes
Associated with Hereditary Retinal Diseases
(HRDs) in Diverse Patients: A New Diagnostic
Platform for IRDs. Chen Zhao. Ophthalmology,
Nanjing Medical University 1st affiliated Hospital,
Nanjing, China
— 1:50 Mitochondrial Optic Neuropathy.
Alfredo A. Sadun. Neuro-Ophthal/Keck-USC Sch of
Med, Doheny Eye Institute, Los Angeles, CA
— 2:00 Discussion
— 2:20 Award to OCAVER Members
6A
Monday, May 06, 2013 1:00 PM-2:30 PM
Retinal Cell Biology / Biochemistry/
Molecular Biology
266 Endocannabinoid Signaling in the
Retina - From Biochemistry to Disease
to Therapy - SIG
This SIG focusses on advances in endocannabinoid
signaling research. Retina and eye specific data as
well as insights from biochemistry, neurophysiology
and pharmacology will be presented with the goal to
identify viable pathways towards therapeutic use in
diseases of the retina.
Moderators: Peter Koulen and Simon Kaja
— Cannabinoid Receptor Expression in the
Retina. Jean-François Bouchard. School of
Optometry, University of Montreal, Montreal, QC,
Canada
6C
— Lipidomic Analysis of Endocannabinoid
Signaling. Kent D. Chapman. University of North
Texas, Denton, TX
Retina / Retinal Cell Biology / Visual
Psychophysics / Physiological Optics / Visual
Neuroscience
6B
Monday, May 06, 2013 1:00 PM-2:30 PM
Glaucoma / Clinical/Epidemiologic Research /
Cornea / Lens / Physiology/Pharmacology
267 Translating Ocular Biomechanics
into Clinical Practice - SIG
Biomechanics is thought to play a critical role in
many ophthalmic disorders. While translational
biomechanics in ophthalmology is still in its
infancy, its use could provide significant advances
in diagnosis and treatment. The aim of this SIG is
to discuss how engineers and clinicians can work
collaboratively to effectively bring biomechanics to
the clinic for the benefit of patients.
Moderators: Michael J. Girard and
Nicholas G. Strouthidis
— SIG Organizer. Michael J. Girard.
Bioengineering, National University of Singapore,
Singapore, Singapore
— Translational Biomechanics: Current
State and Future Prospects. Harry Quigley.
Ophthalmology, Johns Hopkins Wilmer Eye Inst,
Baltimore, MD *CR
— Corneal Biomechanics. William J. Dupps. Cole
Eye Inst and Lerner Rsch Inst, Cleveland Clinic,
Cleveland, OH *CR
— Anterior Segment Biomechanics. Tin Aung.
Glaucoma, Singapore National Eye Center,
Singapore, Singapore *CR
— Lens Biomechanics using Brillouin
Microscopy. Seok H. Yun. Wellman Center for
Photomedicine, Massachusetts Gen Hosp &
Harvard Univ, Cambridge, MA *CR
Monday, May 06, 2013 1:00 PM-2:30 PM
268 Adaptive Optics Retinal Imaging:
Emerging Applications and Expected
Benefits - SIG
Adaptive optics has enabled imaging photoreceptors
and other microscopic retinal structures. Its
translation from lab to clinic is under progress.
Based on recent results, this SIG will discuss the
expected use and benefits of AO in several diseases.
Moderators: Alain Gaudric, Nagahisa Yoshimura,
Jacque L. Duncan and Mark E. Pennesi
— SIG Organizer. Alain Gaudric. Ophthalmology,
Lariboisiere Hospital-University Paris 7, Paris,
France
— AOSLO imaging of inherited retinal
dystrophies. Mina M. Chung. Ophthalmology,
Flaum Eye Inst Univ of Rochester, Rochester, NY
*CR
— Difference of cone abnormalities between
type1 and type2 idiopathic macular
telangiectasia. Sotaro Ooto. Ophthalmology &
Visual Sciences, Kyoto University Graduate School
of Medicine, Kyoto, Japan
— The role of adaptive optics retinal imaging in
patients with type 1 diabetes. Marco Lombardo.
IRCCS Fondazione GB Bietti, Rome, Italy
— Follow-up study of geographic atrophy using
adaptive optics. Kiyoko Gocho. Ophthalmology,
Nippon Med Univ, Chiba Hokusoh Hosp, Inzai,
Japan
— Adaptive optics imaging of the parietal
structure of retinal vessels in health and disease.
Michel Paques. Clinical Investigation Center 503,
Quinze-Vingts Hospital, INSERM, Paris, France
*CR
— Optic Nerve Head Biomechanics. Ian A.
Sigal. Ophthalmology, University of Pittsburgh,
Pittsburgh, PA
— SIG Organizer. Peter Koulen. Ophthalmology/
Vision Research Center, University of MissouriKansas City, Kansas City, MO
— SIG Organizer. Simon Kaja. Ophthalmology,
Univ of Missouri-Kansas City, Kansas City, MO
— Neuroprotection of the Retina by
N-acylethanolamines. Simon Kaja.
Ophthalmology, Univ of Missouri-Kansas City,
Kansas City, MO
— Endocannabinoids in the Retina: From
Marijuana to Neuroprotection. Stephen Yazulla.
Neurobiology & Behavior, Stony Brook University,
Stony Brook, NY
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
160
Monday – Workshops/SIGs
608
609
615-617
Monday, May 06, 2013 1:00 PM-2:30 PM
Monday, May 06, 2013 1:00 PM-2:30 PM
Monday, May 06, 2013 1:00 PM-2:30 PM
Retinal Cell Biology / Biochemistry/Molecular
Biology / Physiology/Pharmacology / Retina
Glaucoma
Cornea / Eye Movements / Strabismus /
Amblyopia / Neuro-Ophthalmology / Glaucoma /
Retinal Cell Biology / Retina
269 Using Stem Cells to Model Retinal
Degenerative Disease - SIG
270 New Insights on the Exploration of
Glaucoma Pathogenesis Using Imaging
Devices - SIG
Recent improvements in imaging technologies
provide high resolution images of deeper layer and
wider area of the eye with sophisticated analyzing
techniques. This SIG will discuss the recent study
outcomes in terms of the exploration of glaucoma
pathogenesis using these imaging techniques.
Moderators: Budd A. Tucker and David M. Gamm
— SIG Organizer. Kyung Rim Sung.
Ophthalmology, Asan Medical Center, University of
Ulsan, Seoul, Republic of Korea
— SIG Organizer. Budd A. Tucker.
Ophthalmology, Inst for Vision Rsrch, Univ of
Iowa, Iowa City, IA
Moderators: Joel S. Schuman and Gadi Wollstein
— SIG Organizer. David M. Gamm.
Ophthalmology and Visual Sciences, Univ of
Wisconsin-Madison, Madison, WI *CR
— Angle closure glaucoma; novel insights
from Anterior Segment Optical Coherence
Tomography imaging. Tin Aung. Glaucoma,
Singapore National Eye Center, Singapore,
Singapore *CR
— Using patient specific iPSCs to model
inherited photoreceptor degenerations. Budd A.
Tucker. Ophthalmology, Inst for Vision Rsrch, Univ
of Iowa, Iowa City, IA
— Optic disc change in children with incipient
myopia; implication for glaucoma development.
Tae-Woo Kim. Ophthalmology, Seoul National Univ
Bundang Hosp, Seongnam, Republic of Korea
— Modeling retinal disease with iPS cells:
How far can we take it? David M. Gamm.
Ophthalmology and Visual Sciences, Univ of
Wisconsin-Madison, Madison, WI *CR
— Macular and choroidal imaging. Kyung Rim
Sung. Ophthalmology, Asan Medical Center,
University of Ulsan, Seoul, Republic of Korea
— Modeling of complement dysregulation in
genotyped human RPE cultures. Dean Bok. Jules
Stein Eye Institute, Univ of California Los Angeles,
Los Angeles, CA
— Lamina cribrosa deformation: cause or
effect of glaucomatous retinal ganglion cell
axonopathy? Sung Chul Park. Department of
Ophthalmology, New York Eye and Ear Infirmary,
New York, NY
— Use of ES/iPS Derived RPE Cells in a Screen
for RPE Cytoprotective and Differentiation
Promoting Molecules. Donald J. Zack.
Ophthalmology, Wilmer Eye Inst, Johns Hopkins
Univ, Baltimore, MD *CR
— Ganglion cell imaging, where are we now?
Christopher K. Leung. 3/F, University Eye Center,
Hong Kong Eye Hospital, Hong Kong, Hong Kong
*CR
Proteomics and metabolomics represent the
highest level of gene expression and are unbiased
methods. This SIG will address issues that will
allow the efficient use of these techniques in
research programs of the attendees; instrumentation,
experimental design, and analysis will be covered.
Moderator: Roger W. Beuerman
— SIG Organizer. Roger W. Beuerman. Singapore
Eye Research Inst, Singapore, Singapore *CR
— Experimental Design and Issues in
Proteomics/Metabolomics, clinical trials. Roger
W. Beuerman. Singapore Eye Research Inst,
Singapore, Singapore *CR
— Matching the instrument to the research
question, new technologies. Lei Zhou. Ocular
Proteomics, Singapore Eye Research Institute,
Singapore, Singapore *CR
— Learning how to use mass spectrometry.
Sanjoy K. Bhattacharya. Bascom Palmer Eye
Institute, Univ of Miami Miller Sch of Med, Miami,
FL
— Proteomics in Glaucoma Research. Franz H.
Grus. Experimental Ophthalmology, University
Medical Center, Mainz, Germany
— Quantitative proteomics. John W. Crabb. Cole
Eye Institute, Cleveland Clinic, Cleveland, OH *CR
TCC 304
— Utilization of retinitis pigmentosa patients’
iPS cells. Masayo Takahashi. Laboratory for Retinal
Regeneration, Ctr for Developmental Biology
RIKEN, Kobe, Japan
Monday, May 06, 2013 1:00 PM-2:30 PM
Retina / Biochemistry/Molecular Biology /
Physiology/Pharmacology
272 Managing Patients with DME,
Neovascular AMD, and RVO: How to
Utilize Data from Clinical Trials - SIG
This SIG will provide a forum for interpretation
of the significance of the results and discussion
as to how the results will be translated into
clinical practice. There will be no rehash of data
presented elsewhere at ARVO. The audience will be
encouraged to participate in the discussion.
Moderator: Quan Dong Nguyen
— SIG Organizer. Quan Dong Nguyen. Diseases
of the Retina & Uveitis, Johns Hopkins Univ,
Wilmer Eye Inst, Baltimore, MD *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
161
Monday Workshops/SIGs
1:00 pm – 2:30 pm
Development of effective treatments for retinal
degenerative disease is highly dependent upon
knowledge of disease mechanism. This SIG will
explore how stem cells, ranging from iPSCs to
tissue specific precursors, can be used to interrogate
disease pathophysiology and in turn aid in the
development of new approaches for treatment of
degenerative retinal diseases.
271 Tips and Techniques for Using
Proteomics and Metabolomics in Your
Clinical and Translational Research SIG
Monday – Workshops/SIGs
— What approach do you use for treatment
with anti-VEGF agents in patients with DME?
Are there DME patients who do not respond to
anti-VEGF agents and if so how does one define/
identify a non-responder? Quan Dong Nguyen.
Diseases of the Retina & Uveitis, Johns Hopkins
Univ, Wilmer Eye Inst, Baltimore, MD *CR
Monday Workshops/SIGs
1:00 pm – 2:30 pm
— Which anti-VEGF agent do you most
commonly use for patients with new onset
macular edema due to CRVO?What is your
current protocol for treatment of patients
with macular edema due to BRVO? Peter A.
Campochiaro. Ophthalmology and Neuroscience,
Johns Hopkins Wilmer Eye Inst, Baltimore, MD
*CR
— Are there greater safety concerns with
the use of bevacizumab than with other antiVEGF agents in DME, AMD, and RVO?
Is there evidence of retinal toxicity from
prolonged suppression of VEGF? Diana V. Do.
Ophthalmology, Johns Hopkins Wilmer Eye Inst,
Baltimore, MD *CR
— Do monthly injections of an anti-VEGF
agent provide better visual outcomes than prn
injections in patients with neovascular AMD? Is
there an advantage to monthly visits with prn
treatment over streamlined monthly visits for
monthly injections? Jeffrey S. Heier. Ophthalmic
Consultants of Boston, Boston, MA *CR
— What is the role of wide-angle retinal imaging
in the management of vaso-occlusive diseases?
What are the major determinants of final visual
outcome in patients with RVO? David M. Brown.
Retina Consultants of Houston, Houston, TX *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
162
Monday – Papers/Minisymposium – 2131 – 2148
6A
Monday, May 06, 2013 2:45 PM-4:30 PM
Biochemistry/Molecular Biology
273 Application of Pharmacologic /
Chemical Biologic Approaches to Eye
Disease - Minisymposium
Application of pharmacology/chemical biology
approaches to eye diseases. These would range
from understanding basic biology or biochemistry,
to animal studies to patient applications (i.e,
translation).
Moderators: T. Michael Redmond and
Terri L. Young
— 2:45 Introduction
2132 — 3:15 Interrogating chemical libraries
for therapeutic insights. James Inglese. PreClinical Innovation, National Center for Advancing
Translational Sciences (NCATS), Rockville, MD
2133 — 3:40 Dietary Omega 3 Fatty Acids
and Retinopathy. Lois E. Smith. Ophthalmology,
Harvard Univ/Childrens Hospital, Boston, MA
2134 — 4:05 A Kinetic Brake to Prevent
Vitamin A Dimerization. Iyas Washington. CUMC,
New York, NY
6B
Monday, May 06, 2013 2:45 PM-4:30 PM
Glaucoma
274 Surgery and Laser
Moderators: Keith Barton, Gunther R. Schlunck
and Mark B. Sherwood
2135 — 2:45 Prospective Randomized Study
Comparing ExPRESS to Trabeculectomy: 1 Year
Results. Yvonne M. Buys1, L. Drori Wagschal4, Y.
Jin2, D. Jinapriya3, G. E. Trope1. 1Ophthalmology
& Vision Sciences, University of Toronto, Toronto,
ON, Canada; 2Dalla Lana School of Public Health,
University of Toronto, Toronto, ON, Canada;
3
Ophthalmology, Queen’s University, Kingston,
ON, Canada; 4Ophthalmology, Shaare Zedek
Medical Center, Jerusalem, Israel *CR, f
2136 — 3:00 SPARC Deficiency Prolongs
Bleb Survival In A Mouse Model Of Glaucoma
Filtration Surgery By Attenuating Proinflammatory and Pro-fibrotic Gene Expression.
Tina Wong1, 2, S. N. Finger2, L. Seet2. 1Singapore
National Eye Centre, Singapore, Singapore; 2Ocular
Therapeutics and Drug Delivery, Singapore Eye
Research Institute, Singapore, Singapore *CR
2138 — 3:30 Comparison of
Phacoemulsification Combined with ab interno
Trabeculectomy (AIT), or with Trabeculectomy
(Trab), and Phaco Alone for the Management
of Cataract and Open-Angle Glaucoma. Marc
Toeteberg-Harms1, S. S. Swaminathan1, S. Jea1, A.
Marvasti2, K. Choi1, J. Kim1, L. R. Pasquale1, D. J.
Rhee1. 1Harvard Medical School, Massachusetts Eye
and Ear Infirmary, Boston, MA; 2Boston University,
School of Medicine, Boston, MA *CR
2139 — 3:45 Characterization of human
ocular fibroblast-subpopulations to prevent
fibrosis following fistulating glaucoma surgeries.
Thomas Stahnke1, M. Löbler2, A. Wree3, O. Stachs1,
K. Schmitz2, R. F. Guthoff1. 1Department of
Ophthalmology, University of Rostock, Rostock,
Germany; 2Institute of Biomedical Engineering,
University of Rostock, Rostock, Germany; 3Institute
of Anatomy, University of Rostock, Rostock,
Germany
2140 — 4:00 Novel Insight into the
Inflammatory and Cellular Responses following
Experimental Glaucoma Surgery: a Roadmap
for Inhibiting Fibrosis. Li-Fong Seet1, 3, T.
Wong1, 2. 1Ocular Therapeutics & Drug Delivery,
Singapore Eye Research Institute, Singapore,
Singapore; 2Department of Ophthalmology, Yong
Loo Lin School of Medicine, National University
of Singapore, Singapore, Singapore; 3Department
of Research, Duke-NUS Graduate Medical School
Singapore, Singapore, Singapore *CR
2141 — 4:15 Excimer Laser Trabeculostomy:
Five Year Post-OP Observations. Richard P.
Stodtmeister1, L. Kleineberg1, M. S. Berlin3, L. E.
Pillunat1, U. F. Giers2. 1Ophthalmology, University
Hospital Carl Gustav Carus, Dresden, Germany;
2
Eye Clinic Detmold, Detmold, Germany;
3
Glaucoma Institute Beverly Hills, Los Angeles,
CA *CR
2143 — 3:00 Prospective study of vitrectomy
for floaters: improvement in contrast sensitivity
and standardized VFQ testing. Kenneth M.
Yee1, 2, L. C. Huang1, 3, C. A. Wa1, 2, A. A. Sadun2, J.
Sebag1, 2. 1VMR Institute, Huntington Beach, CA;
2
Neuro-Ophthalmology, USC/Doheny Eye Institute,
Los Angeles, CA; 3University of Miami School of
Medicine, Miami, FL *CR
2144 — 3:15 Hydroxyl Free-Radical
Formation during Vitrectomy. Nathan Ravi1, 2,
P. D. Hamilton2, 1. 1Ophthalmology and Energy,
Environmental and Chemical Engineering,
Washington University, St Louis, MO;
2
Ophthalmology Research, VA Health Care System,
St. Louis, MO
2145 — 3:30 Thermodynamics of vitreoretinal
surgery in human eyes and implication of
changes in rheology of endotampoandes. Mario
R. Romano1, 2, V. Romano3, R. Vinciguerra1, J. L.
Vallejo-garcia1, C. Costagliola2, P. Vinciguerra3.
1
Ophthalmology, Istituto Clinico Humanitas, Milan,
Italy; 2Ophthalomology, University of Molise,
Campobasso, Italy; 3Ophthalomology, Second
University of Naples, Napoli, Italy *CR
2146 — 3:45 Assessment of Microarchitectural
Changes During Vitrectomy Surgery for
Vitreomacular Traction Syndrome Utilizing
Intraoperative Optical Coherence Tomography.
Tiffany J. Tam1, 2, S. K. Srivastava1, P. K. Kaiser1,
D. F. Martin1, G. M. Smith1, J. P. Ehlers1. 1Cole Eye
Institute, Cleveland Clinic Foundation, Cleveland,
OH; 2Case Western Reserve University School of
Medicine, Cleveland, OH *CR
2147 — 4:00 Time Interval Before Reoperation Influences Visual Outcomes in Repeat
Macular Hole and Macular Pucker Surgery. Billy
X. Pan1, 2, K. M. Yee1, 2, F. N. Ross-Cisneros2, A. A.
Sadun2, J. Sebag1, 2. 1VMR Institute, Huntington
Beach, CA; 2Ophthalmology, USC/Doheny Eye
Inst, Los Angeles, CA *CR
2148 — 4:15 The Value of Routine
Preoperative Medical Testing Before
Vitreoretinal Surgery. Ajay Shalwala1, R. Y.
Hwang1, A. K. Tabing2, S. J. Kim1. 1Vanderbilt Eye
Institute, Nashville, TN; 2Vanderbilt University
School of Medicine, Nashville, TN
6C
Monday, May 06, 2013 2:45 PM-4:30 PM
Retina
275 Vitreoretinal Surgery I
Moderators: Marc D. de Smet and Noemi Lois
2142 — 2:45 Long-term Safety of Vitrectomy
for Patients with Floaters. Christianne A. Wa1, 2,
K. M. Yee1, 2, L. C. Huang2, 3, A. A. Sadun1, 2, J.
Sebag1, 2. 1Neuro-Ophthalmology, USC/ Doheny
Eye Institute, Los Angeles, CA; 2VMR Institute,
Huntington Beach, CA; 3University of Miami
School of Medicine, Miami, FL *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
163
Monday Papers
Minisymposium
2:45 pm – 4:30 pm
2131 — 2:50 Therapeutics and Diagnostics for
the Elimination of Onchocerciasis. Kim D. Janda.
Chemistry, Immunology and Microbial Sciences,
The Scripps Research Institute, La Jolla, CA
2137 — 3:15 One year results of intracameral
bevacizumab as an adjunct to trabeculectomy
in open angle glaucoma patients. Evelien
Vandewalle1, T. Zeyen1, T. Van Bergen2,
L. Spielberg3, W. Spileers1, I. Stalmans2.
1
Ophthalmology, UZ Leuven, Leuven, Belgium;
2
Ophthalmology, KU Leuven, Leuven, Belgium;
3
Ophthalmology, Rotterdam Eye Hospital,
Rotterdam, Netherlands f
2149 – 2166 – Monday – Papers/Minisymposium
6E
Monday, May 06, 2013 2:45 PM-4:30 PM
Glaucoma
276 Imaging II, GL
2155 — 4:15 Axonal Transport Deficits Exceed
Retinal Nerve Fiber Layer (RNFL) Changes
after 3-weeks of Chronic Intraocular Pressure
(IOP) Elevation in Young and Old Rats. Carla
J. Abbott, T. E. Choe, C. F. Burgoyne, B. Fortune.
Discoveries in Sight Research Laboratories, Devers
Eye Institute and Legacy Research Institute, Legacy
Health, Portland, OR *CR
Monday Papers/
Minisymposium
2:45 pm – 4:30 pm
Moderators: David Huang and Ernst R. Tamm
2149 — 2:45 Enhancement of Lamina Cribrosa
Visibility in Optical Coherence Tomography
Images using Adaptive Compensation.
Nicholas G. Strouthidis1, 2, J. Mari3, S. Park4, 5,
M. J. Girard2, 6. 1Glaucoma Research Unit, NIHR
Biomedical Research Centre at Moorfields Eye
Hospital NHS Foundation Trust and UCL Institute
of Ophthalmology, London, United Kingdom;
2
Singapore Eye Research Institute, Singapore,
Singapore; 3INSERM 1032, Université de Lyon,
Lyon, France; 4Moise and Chella Safra Advanced
Ocular Imaging Laboratory, Einhorn Clinical
Research Center, New York Eye and Ear Infirmary,
New York, NY; 5Department of Ophthalmology,
New York Medical College, Valhalla, NY; 6In
Vivo Biomechanics Laboratory, Department of
Bioengineering, National University of Singapore,
Singapore, Singapore
2150 — 3:00 Peripapillary choroidal volume
in eyes with and without primary open-angle
glaucoma. Michael Sullivan-Mee1, N. B. Patel2, D.
Pensyl1, K. D. Halverson1. 1Optometry, Albuquerque
VA Med Center, Albuquerque, NM; 2University of
Houston, College of Optometry, Houston, TX
2151 — 3:15 Association between Iris Surface
Features and Iris Thickness in Asian Eyes.
Elizabeth Sidhartha1, 2, P. GUPTA1, 2, J. Liao1,
Y. Tham1, 2, C. Y. Cheung1, 2, T. Y. Wong1, 2, T.
Aung1, 2, C. Cheng1, 2. 1Singapore Eye Research
Institute, Singapore, Singapore; 2Department of
Ophthalmology, National University of Singapore,
Singapore, Singapore *CR
2152 — 3:30 Magnification Errors after
Refractive Change by Cataract Surgery on
Optic Nerve Head Analysis. Kazuhiko Mori,
T. Nakayama, Y. Ikeda, M. Ueno, H. Yoshikawa,
Y. Maruyama, S. Kinoshita. Department of
Ophthalmology, Kyoto Prefectural Univ of Med,
Kamigyo-Ku, Japan *CR
2153 — 3:45 Lamina Cribrosa Reversal
after Trabeculectomy : Long-term Followup Result. Tae-Woo Kim1, 2, E. Lee1, 2, R. N.
Weinreb3. 1Ophthalmology, Seoul National
University College of Medicine, Seoul, Republic
of Korea; 2Ophthalmology, Seoul National Univ
Bundang Hosp, Seongnam, Republic of Korea;
3
Ophthalmology, University of California San
Diego, La Jolla, CA *CR
2154 — 4:00 A prospective study on laminar
and pre-laminar displacement in patients with
chronic progressive glaucoma. Zhongheng Wu,
S. Biswas, C. K. Leung. CUHK, Hong Kong, Hong
Kong *CR
606/607
Monday, May 06, 2013 2:45 PM-4:30 PM
Immunology/Microbiology
277 Corneal Infection and
Inflammation
2161 — 4:00 IL-23 and CCL20 in the corneal
response to epithelial abrasion. Yuan Gao1, 3, A.
R. Burns2, C. W. Smith1. 1Pediatrics, Baylor College
of Medicine, Houston, TX; 2College of Optometry,
University of Houston, Houston, TX; 3Clinical
College of Ophthalmology, Tianjin Medical
University, Tianjin, China
2162 — 4:15 Molecular Epidemiology of
Methicillin Resistant Staphylococcus aureus
(MRSA) Causing Ocular Infections in South
India. Nithya Velusamy1, R. Sivakumar2, L.
Prajna1. 1Microbiology, Aravind Medical Research
Foundation, Madurai, India; 2Department of Uvea,
Aravind Eye Hospital and Post Graduate Institute of
Ophthalmology, Madurai, India
609
Moderators: James Chodosh and Deepak Shukla
Monday, May 06, 2013 2:45 PM-4:30 PM
2156 — 2:45 Adenoviral Pathogenesis in
Epidemic Keratoconjunctivitis: the Failure
of Hexon Gene Sequence to Predict Corneal
Tropism. James Chodosh1, G. Singh1, X. Zhou1, J.
Rajaiya1, M. A. Yousuf1, J. Lee1, C. M. Robinson1,
D. Seto2, D. Dyer3, M. S. Jones2. 1Ophthalmology,
Mass Eye & Ear - Harvard Medical School,
Boston, MA; 2School of Systems Biology, George
Mason University, Manassas, VA; 3Microbiology
and Immunology, University of Oklahoma Health
Sciences Center, Oklahoma City, OK *CR
Lens / Retinal Cell Biology
2157 — 3:00 Establishing a New Role for
the Enzyme Heparanase in Ocular Herpes
Infection. Deepak Shukla. Ophthal/Visual Sciences,
University of Illinois at Chicago, Chicago, IL
2158 — 3:15 The role of corneal Plasmacytoid
Dendritic Cells in acute herpes simplex virus
infection. Kai Hu1, 2, D. L. Harris2, T. Yamaguchi1, 2,
H. Ghiasi4, U. von Andrian3, P. Hamrah1, 2.
1
Ophthalmology, Massachusetts Eye & Ear
Infirmary, Boston, MA; 2Schepens Eye Research
Institute, Boston, MA; 3Immune Disease Institute,
Program in Cellular and Molecular Medicine at
Children’s Hospital, Boston, MA; 4Ophthalmology
Research, Cedar Sinai Medical Center, Los Angeles,
CA
2159 — 3:30 In Vivo Confocal Microscopy
Demonstrates Bilateral Increase in Epithelial
Corneal Dendritic Immune Cells in Unilateral
Herpes Zoster Ophthalmicus. Bernardo M.
Cavalcanti1, 2, A. Cruzat1, 2, D. Pavan-Langston1,
E. A. Samayoa1, 2, P. Hamrah1, 2. 1Department of
Ophthalmology - Cornea & Refractive Surgery,
Massachusetts Eye & Ear Infirmary, Harvard
Medical School Department of Ophthalmology,
Boston, MA; 2Department of Ophthalmology Ocular Surface Imaging Center, Massachusetts
Eye & Ear Infirmary, Harvard Medical School
Department of Ophthalmology, Boston, MA *CR
2160 — 3:45 Penetrating keratoplasty to one
eye abolishes immune privilege and promotes
corneal allograft rejection in the opposite
eye, even to grafts from unrelated donors.
Jerry Y. Niederkorn, K. Paunicka, J. Mellon.
Ophthalmology, Univ Texas Southwestern Med Ctr,
Dallas, TX *CR
278 Regulation of Eye Development via
Common Transcription Factors and
Signaling Pathways-Minisymposium
Major advances in the field of ocular development
offer novel insights into the causes of ocular
developmental abnormalities in human and provide
insight into the formation of eye at the cellular,
molecular and genetic levels. Understanding of
normal eye development is required for better
diagnosis and treatment of ocular defects including
the rational design of cell replacement therapies
that include adult stem cells and tissue-engineering
using cells generated through the process of
embryonic stem (ES) cell differentiation. The goal
of this Minisymposium is to provide an integrative
view of eye development and to demonstrate
multifunctionality of key regulatory genes such
as Pax6, Sox2 and AP-2 in different eye cells
and tissues. Studies in Drosophila have led to
novel concepts how signals from multiple signal
transduction pathways converge to regulate a small
network of regulatory genes using combinatorial
principles that are generally applicable for
mammalian systems.
Moderators: Ales Cvekl and Ruth Ashery-Padan
2163 — 2:45 Regulation of Drosophila Eye
Development via Common Transcription
Factors and Signaling Pathways. Nicholas Baker.
Genetics, Albert Einstein College of Medicine,
Bronx, NY
2164 — 3:10 Pax6 and Sip1 in Lens and
Retinal Development. Ruth Ashery-Padan. Human
Molecular Genetics and Biochemistry, Tel-Aviv
University, Tel Aviv, Israel
2165 — 3:30 Foxe3 and Lens Development.
Olga Medina-Martinez. Molecular & Cellular
Biology, Baylor College of Medicine, Houston, TX
2166 — 3:50 Notch Signaling in the
Mammalian Eye. Nadean L. Brown. Cell Biology
and Human Anatomy, University of California
Davis, Davis, OH
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
164
Monday – Papers/Minisymposium – 2167 – 2181
2167 — 4:10 Role of AP-2 Genes in Lens
and Retinal Development. Judith A. West-Mays.
Dept of Path/Molec Med, McMaster University,
Hamilton, ON, Canada
615-617
Monday, May 06, 2013 2:45 PM-4:30 PM
Clinical/Epidemiologic Research
279 Retinal Health and Diabetic
Retinopathy: Evidence for Mechanisms,
Treatment, and Risk
Moderators: Tunde Peto and Fang Ko
2169 — 3:00 A Population Based ultra
wide-field digital image grading study for
AMD-like pathologies at the peripheral retina.
Imre Lengyel1, F. Jonasson3, G. Thorleifsson4,
A. Csutak5, T. Peto2. 1Ocular Biology and
Therapeutics, UCL Institute of Ophthalmology,
London, United Kingdom; 2Reading centre, NIHR
Biomedical Research Centre for Ophthalmology,
at Moorfields Eye Hospital NHS Foundation Trust
and UCL Institute of Ophthalmology, London,
United Kingdom; 3Department of Ophthalmology,
Landspitali University Hospital, Reykjavik, Iceland;
4
DECODE, Reykjavik, Iceland; 5Department of
Ophthalmology, University of Debrecen, Debrecen,
Hungary *CR
2170 — 3:15 Potential Targets for Preventative
Eye Care Among those with Diabetes. Fang Ko1,
S. Vitale2, D. S. Friedman1, 3. 1Wilmer Eye Institute,
Johns Hopkins, Baltimore, MD; 2Division of
Epidemiology and Clinical Applications, National
Eye Institute, Bethesda, MD; 3Johns Hopkins
Bloomberg School of Public Health, Baltimore,
MD *CR
2171 — 3:30 Epidemiology of retinopathy in
African Americans with impaired fasting glucose
and type 2 diabetes in the Jackson Heart Study.
Lucia Sobrin1, A. Penman2, 3, S. T. Hoadley4, J. G.
Wilson2, H. A. Taylor2, C. J. Chen4. 1Retina/Uveitis,
Harvard Med Mass Eye & Ear Infirmary, Boston,
MA; 2Medicine, University of Mississippi Medical
Center, Jackson, MS; 3Biostatistics, University
of Mississippi Medical Center, Jackson, MS;
4
Ophthalmology, University of Mississippi Medical
Center, Jackson, MS
2173 — 4:00 Are Routine Retinal Examinations
useful for Patients with Dementia? Mark Wong1,
C. Y. Cheung1, 2, Y. Ong1, 3, S. Hilal4, 5, Y. Zheng1, M.
Chew1, P. Yap6, D. Seow7, C. Chen4, 5, T. Y. Wong1, 3.
1
Singapore Eye Research Institute, Singapore,
Singapore; 2Centre for Quantitative Medicine,
Duke-NUS Graduate Medical School, Singapore,
Singapore; 3Department of Ophthalmology, Yong
Yoo Lin School of Medicine, Singapore, Singapore;
4
Memory Aging and Cognition Centre, National
University Health System, Singapore, Singapore;
5
Department of Pharmacology, National University
of Singapore, Singapore, Singapore; 6Department
of Geriatric Medicine, KhooTeckPuat Hospital,
Singapore, Singapore; 7Department of Geriatric
Medicine, Singapore General Hospital, Singapore,
Singapore *CR
2174 — 4:15 Vision-Threatening Diabetic
Retinopathy and Incident Cardiovascular
Disease: A Systematic Review and MetaAnalysis. Mohammad K. Ikram1, J. Xie2, M. Cotch3,
B. E. Klein4, P. Mitchell5, J. Shaw6, R. Varma7,
E. L. Lamoureux2, T. Y. Wong1. 1Singapore Eye
Research Institute, Singapore, Singapore; 2Centre
for Eye Research Australia, Melbourne, VIC,
Australia; 3Division of Epidemiology and Clinical
Applications, National Eye Institute, Intramural
Research Program, National Institutes of Health,
Bethesda, MD; 4Department of Ophthalmology and
Visual Sciences, University of Wisconsin School
of Medicine and Public Health, Madison, MD;
5
Department of Ophthalmology and Westmead
Millenium Institute, Centre for Vision Research,
University of Sydney, Sydney, NSW, Australia;
6
Baker IDI Heart and Diabetes Institute, Melbourne,
VIC, Australia; 7Department of Ophthalmology and
Visual Sciences, University of Illinois College of
Medicine at Chicago, Chicago, IL *CR
618-620
Monday, May 06, 2013 2:45 PM-4:30 PM
Physiology/Pharmacology
280 AMD and Drugs
Moderators: Teresio Avitabile, Jeffrey W. Kiel and
Pinakin G. Davey
2175 — 2:45 A Phase 2b Study of Fovista™, a
Platelet Derived Growth Factor (PDGF) inhibitor
in combination with a Vascular Endothelial
Growth Factor (VEGF) inhibitor for Neovascular
Age-Related Macular Degeneration (AMD). David
S. Boyer. Ophthalmology, Retina Vitreous Assoc
Med Group, Los Angeles, CA *CR, f
2176 — 3:00 Multifunctional Antioxidants
Protect Cells From Mitochondrial Dysfunction
and Abeta Neurotoxicity. Hiroyoshi Kawada1, P.
F. Kador1, 2. 1Pharmaceutical Sciences, University
of Nebraska Medical Center, Omaha, NE;
2
Ophthalmology, University of Nebraska Medical
Center, Omaha, NE *CR
2177 — 3:15 Integrin Peptide Therapy:
The First Wet AMD Experience. Peter K.
Kaiser1, D. S. Boyer2, P. A. Campochiaro5, J.
Guerrero-Naranjo8, J. S. Heier7, J. Kornfield6,
B. D. Kuppermann3, H. Quiroz-Mercado4, S.
Salinas Longoria8, S. Schwartz4. 1Division of
Ophthalmology, Cole Eye Institute, Cleveland,
OH; 2Retina Vitreous Associates, Los Angeles, CA;
3
Dept of Ophthalmology, Unversity of California,
Irvine, Irvine, CA; 4Dept of Ophthalmology,
Unversity of Colorado, Denver, Denver, CO; 5Dept
of Ophthalmology, Wilmer Eye Institute - Johns
Hopkins, Baltimore, MD; 6Dept of Chemical
Engineering, California Institute of Technology,
Pasadena, CA; 7Ophthalmic Consultants of Boston,
Boston, MA; 8Dept of Ophthalmology, Association
Para Evitar La Ceguera, Mexico City, Mexico
*CR, f
2178 — 3:30 Topical Pazopanib for the
Treatment of Previously Untreated Choroidal
Neovascularization due to Age-related Macular
Degeneration. Rishi Singh1, J. I. Wurzelmann2,
L. Ye3, M. A. Fries4, J. Norris2, M. Hossain4, T. M.
Trivedi4, D. S. Kelly4. 1Cole Eye Institute, Cleveland
Clinic, Cleveland, OH; 2GlaxoSmithKline,
Research Triangle Park, NC; 3GlaxoSmithKline,
Upper Providence, PA; 4GlaxoSmithKline, King of
Prussia, PA *CR, f
2179 — 3:45 IKK2 Inhibition Using TPCA1/PLGA Microspheres Attenuates the Laser
Induced Choroidal Neovascularization. Qiutang
Li1, 2, S. Gaddipati1, 2, M. Miller2, J. O. Trent2, 3, H.
J. Kaplan1, Q. Lu1, 2. 1Department of Ophthal and
Visual Science, University of Louisville, Louisville,
KY; 2JG Brown Cancer Center, University of
Louisville, Louisville, KY; 3Department of
Medicine, University of Louisville, Louisville, KY
2180 — 4:00 Effects of intravitreally injected
ranibizumab and aflibercept on retina and
choroid of monkey eyes. Ulrich Schraermeyer, S.
Julien. Experimental Vitreoretinal Surgery, Centre
for Ophthalmology, Tubingen, Germany *CR
2181 — 4:15 Development and Implementation
of an ELISA to Detect “Anti- Ranibizumab”
Immunity in Age-Related Macular Degeneration
Patients. Aaron L. Magno1, 2, M. Lai1, 2, C. Pierce1,
K. M. Davern3, M. E. Wikstrom4, T. W. Chalberg5,
I. Constable2, E. P. Rakoczy1, 2. 1Molecular
Ophthalmology, Lions Eye Institute, Perth, WA,
Australia; 2Centre for Ophthalmology and Visual
Sciences, The University of Western Australia,
Perth, WA, Australia; 3Monoclonal Antibody
Facility, Western Australian Institute for Medical
Research, Perth, WA, Australia; 4Centre for
Experimental Immunology, Lions Eye Institute,
Perth, WA, Australia; 5Avalanche Biotechnologies,
San Francisco, CA *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
165
Monday Papers
Minisymposium
2:45 pm – 4:30 pm
2168 — 2:45 The Relationship between
Axial Length, Retinal Function, and Oxygen
Consumption: A Potential Protective Mechanism
in Diabetic Retinopathy. Ryan Man1, E. L.
Lamoureux1, 2, Y. Taouk1, J. Xie1, J. E. Noonan1,
R. Kawasaki1, J. Wang1, 3, C. D. Luu1. 1Centre for
Eye Research Australia, University of Melbourne,
East Melbourne, VIC, Australia; 2Singapore Eye
Research Institute, Singapore, Singapore; 3Centre
for Vision Research, Westmead Millenium institute,
Sydney, NSW, Australia
2172 — 3:45 Real-World Utilization of AntiVEGFs in Diabetic Macular Edema and Retinal
Vein Occlusion: Injection Frequency, Patient
Monitoring, and Concomitant Therapy Use.
Szilard Kiss1, Y. Liu2, J. Brown3, N. M. Holekamp4,
A. Almony5, J. Campbell2, J. W. Kowalski2.
1
Ophthalmology, Weill Cornell Medical College,
New York, NY; 2Allergan, Inc., Irvine, CA; 3IMS
Health, Inc., Woodland Hills, CA; 4Washington
University School of Medicine, St. Louis, MO;
5
Carolina Eye Associates, Southern Pines, NC *CR
2182 – 2200 – Monday – Papers/Minisymposium
TCC LL 4/5
TCC 303
Monday, May 06, 2013 2:45 PM-4:30 PM
Monday, May 06, 2013 2:45 PM-4:30 PM
Visual Psychophysics / Physiological Optics
Cornea
281 Low Vision: Central Vision Loss
282 Dry Eye and Lacrimal Gland II
Moderators: George T. Timberlake and
Susana T. Chung
Moderators: Gordon W. Laurie and
Harumitsu Hirata
2182 — 2:45 Optical attachment for
binocular imaging with the Scanning Laser
Ophthalmoscope (SLO). George T. Timberlake1,
W. Ward2. 1Research, Kansas City VA Medical
Center, Kansas City, MO; 2Ward Electro-Optics,
Inc., Gallatin, MO
2189 — 2:45 Fully Functional Bioengineered
Lacrimal Gland Regeneration as an Organ
Replacement Regenerative Therapy. Masatoshi
Hirayama1, M. Ogawa2, M. Oshima3, T.
Kawakita1, S. Shimmura1, T. Tsuji2, 3, K. Tsubota1.
1
Ophthalmology, Keio Univ School of Medicine,
Tokyo, Japan; 2Organ Technologies Inc., Tokyo,
Japan; 3Research Institute for Science and
Technology, Tokyo University of Science, Chiba,
Japan *CR
Monday Papers/
Minisymposium
2:45 pm – 4:30 pm
2183 — 3:00 Does the location of the PRL
correspond to the retinal location with the best
acuity? Susana T. Chung, J. Bernard. School of
Optometry, University of California, Berkeley, CA
2184 — 3:15 Retinal Fixation Locus in Patients
with Bilateral Central Scotomas: Letter Targets
are Better Suited for Visual Testing than Targets
that Fill in. Joshua Pratt, H. E. Bedell, J. M.
Ohara, S. Woo. University of Houston College of
Optometry, Houston, TX
2185 — 3:30 Qualitative and Quantitative
Assessment of Metamorphopsia in Retinopathy
Patients. Emily K. Wiecek1, 2, K. Lashkari2, 3, S. C.
Dakin1, 4, P. Bex2, 3. 1Institute of Ophthalmology,
University College London, London, United
Kingdom; 2Opthalmology, Harvard Medical,
Boston, MA; 3Opthalmology, Massachusetts Eye
and Ear, Boston, MA; 4NIHR Biomedical Research
Centre for Ophthalmology, Moorfields Eye
Hospital, London, United Kingdom *CR
2186 — 3:45 The effects of central and
peripheral visual losses on reaching and
grasping. Aachal Kotecha1, 2, R. T. Fahy2, G. S.
Rubin2, 1. 1NIHR BRC for Ophthalmology, UCL
Institute of Ophthalmology & Moorfields Eye
Hospital, London, United Kingdom; 2Visual
Neuroscience, UCL Institute of Ophthalmology,
London, United Kingdom
2187 — 4:00 Effect of central vision loss on
mutual gaze perception. Alexandra R. Bowers1,
S. S. Sheldon1, J. Quint2, H. Hecht3. 1Schepens
Eye Res Inst, Mass Eye and Ear, Ophthalmology,
Harvard Med School, Boston, MA; 2Indiana
University School of Optometry, Bloomington, IN;
3
Psychologisches Institut, Johannes GutenbergUniversitat, Mainz, Germany
2188 — 4:15 Association of Self-Reported
Task Difficulty with Binocular Central Scotoma
Locations. Nicole C. Ross, J. E. Goldstein, R. W.
Massof. Ophthalmology, Johns Hopkins Univeristy,
School of Medicine, Baltimore, MD
2190 — 3:00 Identification of Novel
Epithelial Stem/Progenitor Cell Population in
Murine Uninjured Lacrimal Gland. Helen P.
Makarenkova1, A. Gromova1, D. Voronov1, 2, M.
Yoshida1, R. Meech3. 1Cell and Molecular biology,
The scripps Research Institute, La Jolla, CA;
2
Institute for Information Transmission Problems,
Russian Academy of Sciences, Moscow, Russian
Federation; 3Department of Clinical Pharmacology,
Flinders University, Bedford Park, SA, Australia
2191 — 3:15 Stem-like Cells in Serum Free
In-vitro Cultures of Human Lacrimal Gland.
Shubha Tiwari1, M. J. Ali1, M. Balla1, M. N. Naik1,
S. Honavar1, V. R. Palkonda1, G. K. Vemuganti2, 1.
1
Stem Cell Biology Lab, L V Prasad Eye Institute,
Hyderabad, India; 2School of Medical Sciences,
University of Hyderabad, Hyderabad, India
2192 — 3:30 Umbilical mesenchymal stem cell
transplantation for dry eye in the mouse model.
Hongshan Liu, Y. Zhang, Y. Yuan, J. Zhang, C. Liu,
W. Kao. Ophthalmology, University of Cincinnati,
Cincinnati, OH
2193 — 3:45 Short exposure to intense tear
hyperosmolarity leads to functional alterations
of the corneal nerves involved in tearing
and/or ocular pain: Implications for dry eye
disease. Harumitsu Hirata, M. L. Oshinsky, N. T.
Fried. Neurology, Thomas Jefferson University,
Philadelphia, PA
2194 — 4:00 Mice with Desiccating StressInduced Dry Eye Develop Trigeminal Neuralgia,
Despite Decreased Corneal Sensitivity and Nerve
Fiber Degeneration. Chris S. Schaumburg1, K.
S. Held1, E. Oh1, S. Ugarte1, L. A. Wheeler1, M.
Calonge2, J. Y. Niederkorn3, S. C. Pflugfelder4,
R. I. Fox5, M. E. Stern1. 1Biological Sciences,
Allergan, Irvine, CA; 2IOBA, University of
Valladolid, Valladolid, Spain; 3Ophthalmology,
UT Southwestern Med Center, Dallas, TX;
4
Ophthalmology, Baylor College of Medicine,
Houston, TX; 5Division of Reumatology, Scripps
Memorial Hospital, Lo Jolla, CA *CR
2195 — 4:15 Multiplexed Quantitative
Analysis of 51 Proteins in Human Tears using
High Resolution Multiple Reaction Monitoring
(HR-MRM) Mass Spectrometry. Lei Zhou1, 2, L.
Tong1, R. W. Beuerman1, 2. 1Singapore Eye Research
Institute, Singapore, Singapore; 2Ophthalmology,
National University of Singapore, Singapore,
Singapore *CR
TCC 304
Monday, May 06, 2013 2:45 PM-4:30 PM
Cornea
283 Endothelium
Moderators: Shiro Amano and Albert S. Jun
2196 — 2:45 Decline in DJ-1 Leads to
Decreased Nuclear Translocation of Nrf2 and
Results in p53-mediated Apoptosis of Human
Corneal Endothelial Cells. Cailing Liu, Y. Chen,
U. V. Jurkunas. Schepens/Massachusetts Eye
and Ear, Department of Ophthalmology, Harvard
Medical School, Boston, MA *CR
2197 — 3:00 MicroRNA Analysis in Fuchs
Endothelial Corneal Dystrophy. Mario
Matthaei1, 2, J. Hu1, L. Kallay1, C. Cursiefen2, J.
Qian1, A. S. Jun1. 1Anterior Segment / Cornea,
Wilmer Eye Inst, Johns Hopkins Univ, Baltimore,
MD; 2Department of Ophthalmology, University of
Cologne, Cologne, Germany *CR
2198 — 3:15 Identification of New markers
of Human Corneal Endothelial Cells. Jodhbir S.
Mehta1, A. Cheong2, G. S. Peh1, W. Sun2. 1Cornea
Refractive Tissue Engineering, SNEC / SERI,
Singapore, Singapore; 2Experimental Therapeutic
Unit, A Star, Singapore, Singapore *CR
2199 — 3:30 Tight Junction Transmembrane
Protein Claudin Subtype Expression and
Distribution in Human Corneal Endothelium.
Emi Inagaki, S. Hatou, S. Yoshida, H. Miyashita,
K. Tsubota, S. Shimmura. Ophthalmology, Keio
University, Tokyo, Japan *CR
2200 — 3:45 Corneal endothelial cells provide
evidence of accelerated cellular senescence
associated with HIV infection: a case-control
study. Sophia Pathai1, 2, S. D. Lawn3, 2, P. G. Shiels5,
H. A. Weiss4, C. Cook6, R. Wood2, C. E. Gilbert1.
1
International Centre for Eye Health, London
School of Hygiene & Tropical Medicine, London,
United Kingdom; 2Desmond Tutu HIV Centre,
University of Cape Town, Cape Town, South
Africa; 3Dept of Clinical Research, London School
of Hygiene & Tropical Medicine, London, United
Kingdom; 4MRC Tropical Epidemiology Group,
London School of Hygiene & Tropical Medicine,
London, United Kingdom; 5Dept of Epigenetics,
Institute of Cancer Sciences, University of
Glasgow, Glasgow, United Kingdom; 6Dept of
Ophthalmology, University of Cape Town, Cape
Town, South Africa *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
166
Monday – Papers/Minisymposium – 2201 – 2207
2201 — 4:00 Efficacy and Safety Evaluation of
Cell-Injection Therapy using Cultivated Human
Corneal Endothelial Cells. Noriko Koizumi1, 2, N.
Okumura1, 2, T. Shiina3, S. Suzuki3, S. Nakamura4,
Y. Sakamoto1, K. Yamasaki1, M. Ueno2, J. Hamuro2,
S. Kinoshita2. 1Biomedical Engineering, Doshisha
University, Kyotanabe City, Japan; 2Ophthalmology,
Kyoto Prefectural University of Medicine, Kyoto,
Japan; 3Molecular Life Sciences, Tokai University
School of Medicine, Isehara, Japan; 4Research
Center for Animal Life Science, Shiga University of
Medical Science, Otsu, Japan *CR
2206 — 3:50 ER Stress as a Target for Retinal
Ganglion Cell and CNS Neuroprotection. Yang
Hu. Shriners Research Center, Temple University
School of Medicine, Philadelphia, PA
2207 — 4:10 Molecular Pathways Mediating
Neuronal Plasticity and Development in
Thalamus and Visual Cortex. Elizabeth M.
Quinlan. University of Maryland, College Park, MD
2202 — 4:15 Activation of the Rho/ROCK
Signaling Pathway in the Apoptosis of Corneal
Endothelial Cells. Naoki Okumura1, 2, A.
Odajima1, 2, E. P. Kay1, W. Chen1, M. Ueno2, J.
Hamuro2, S. Kinoshita2, N. Koizumi1. 1Biomedical
Engineering, Doshisha University, Kyotanabe,
Japan; 2Ophthalmology, Kyoto Prefectural
University of Medicine, Kyoto, Japan *CR
Monday Papers
Minisymposium
2:45 pm – 4:30 pm
TCC 305
Monday, May 06, 2013 2:45 PM-4:30 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology / Glaucoma / Retinal Cell
Biology / Visual Neuroscience
284 Neuroprotection in the Visual
Pathway: Common Mechanisms
in Retina, Optic Nerve and BrainMinisymposium
This minisymposium will introduce the attendants
to the latest progress in our understanding
of molecular mechanisms involved in
neurodegenerative processes, where modulation
provides neuroprotective effects. Emphasis will
be placed on generating discuss about potential
common pathways involved in various cells and
diseases as a means of identifying targets for broadbased neuroprotective strategies.
Moderators: Benjamin Thompson and
Kenneth S. Shindler
— 2:45 Introduction
2203 — 2:50 RPE And Neurosensory Retina
Degeneration. Overlapping Mechanisms with
CNS Neurodegenerative Disease. Joshua L.
Dunaief. FM Kirby Ctr/Ophthalmology, University
of Pennsylvania Library, Philadelphia, PA *CR
2204 — 3:10 Mechanisms of Erythropoeitin
Mediated Photoreceptor and Ganglion Cell
Neuroprotection. Tonia S. Rex. Ophthalmology,
Vanderbilt University, Nashville, TN *CR
2205 — 3:30 Oxidation-Dependent Signaling
as a Target for Retinal Ganglion Cell and
Photoreceptor Neuroprotection. Leonard A. Levin.
Ophthalmology, McGill University, Montreal, QC,
Canada *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
167
2208 – 2229 – Monday – Posters
Exhibit Hall A0077-A0113
Monday, May 06, 2013 2:45 PM-4:30 PM
Retinal Cell Biology
285 Stem and iPS Cells
Moderator: Marcus Fruttiger
Monday Posters
2:45 pm – 4:30 pm
2208 — A0077 Transforming growth factor
beta secretion by human embryonic stem cell
derived retinal pigment epithelium. Hossein
Nazari Khanamiri1, 2, D. Zhu3, 4, C. Spee1, 4, M. S.
Humayun1, 4, D. R. Hinton3, 4. 1Ophthalmology, Keck
School of Medicine of the University of Southern
California, Los Angeles, CA; 2Ophthalmology,
Rassoul Akram Hospital, Tehran University of
Medical Sciences, Tehran, Islamic Republic of
Iran; 3Pathology, Keck School of Medicine of the
University of Southern California, Los Angeles,
CA; 4Doheny Eye Institute, Los Angeles, CA *CR
2209 — A0078 Identification of transcriptional
regulators underlying retinal fate determination
from human induced pluripotent stem cells.
Akshayalakshmi Sridhar1, M. M. Steward1, M.
Gupta1, J. S. Meyer1, 2. 1Department of Biology,
Indiana University Purdue University Indianapolis,
Indianapolis, IN; 2Stark Neuroscience Research
Institute, Indiana University, Indianapolis, IN
2210 — A0079 Human neural stem cells
phagocytose photoreceptor outer segments and
preserve synaptic contacts in the degenerating
rodent retina. Alexandra Capela1, L. FernandezSanchez2, T. J. McGill3, B. Lu4, R. Lund5, S. Huhn1,
N. Cuenca2. 1Neural Group, StemCells Inc, Newark,
CA; 2Physiology, Genetics and Microbiology,
University of Alicante, Alicante, Spain; 3Casey Eye
Institute, Oregon Health and Science University,
Portland, OR; 4Regenerative Medicine Institute,
Cedars Sinai Medical Center, Los Angeles, CA;
5
Moran Eye Center, University of Utah, Salt Lake
City, UT *CR
2211 — A0080 Evaluation of Spontaneous
Differentiation of hESCs into RPE Cells in the
Absence of bFGF. Lee R. Ferguson, S. Grover, K.
Chalam. Ophthalmology, University of Florida,
Jacksonville, FL
2212 — A0081 Differentiation and
characterization of retinal ganglion cells
derived from human induced pluripotent stem
cells. Jason S. Meyer1, 2, A. Sridhar1, M. Gupta1,
M. M. Steward1. 1Biology, Indiana University
Purdue University Indianapolis, Indianapolis, IN;
2
Stark Neurosciences Research Institute, Indiana
University, Indianapolis, IN
2213 — A0082 Notch mediated activation of
mammalian Müller stem cells. Iqbal Ahmad, C.
B. Del Debbio, S. Parameswaran. Ophthalmology
& Visual Sciences, Univ of Nebraska Medical Ctr,
Omaha, NE
2214 — A0083 HMGA2 regulates the
self-renewal of retinal progenitors. Sowmya
Parameswaran, I. Ahmad. Ophthalmology and
Visual Sciences, University of Nebraska Medical
Center, Omaha, NE
2215 — A0084 Involvement of miRNAs in the
regulation of Retinal Stem Cells. Xiaohuan Xia,
I. Ahmad. Ophthalmology and Visual Sciences,
University of Nebraska Medical Center, Omaha, NE
2216 — A0085 De novo formation of vascular
structures in vitro. Georgios Kontos1, 2, P.
Antonopoulou2, D. A. Sim2, J. Mckenzie2, M.
Fruttiger2. 1Macclesfield District General Hospital,
Macclesfield, United Kingdom; 2UCL Institute of
Ophthalmology, London, United Kingdom *CR
2217 — A0086 Bone marrow-derived stem cells
repair retinal vasculature in mouse model of
oxygen-induced retinopathy. Baraa Noueihed1, 2,
M. Blais2, J. Rivera2, A. Madaan1, 2, S. Chemtob1, 2.
1
Pharmacology and Therapeutics, McGill
University, Montreal, QC, Canada; 2Ste-Justine
Hospital Research Center, Montreal, QC, Canada
2218 — A0087 Generation of Retinal
Precursors using Human Embryonic and
Induced Pluripotent Stem Cells: Comparison
of the Efficiency of Differing Cell Culture
Conditions. Conor Ramsden, M. B. Powner, P.
J. Coffey. ORBIT, Institute of Ophthalmology,
London, United Kingdom *CR
2219 — A0088 Long-term Efficacy and Safety
of an RPE Cell Monolayer Derived From
Human Embryonic Stem Cells Implanted
into the Subretinal Space of the RCS Rat.
Ramiro Ribeiro1, 2, M. J. Koss1, 4, B. Diniz1, 3, R.
A. Brantfernandes1, 3, L. Liu1, 5, P. B. Thomas1, B.
B. Thomas1, 6, G. J. Chader1, 6, D. R. Hinton1, 6,
M. S. Humayun1, 6. 1Ophthalmology, Doheny Eye
Institute, Los Angeles, CA; 2Ophthalmology,
FEPAR, Curitiba, Brazil; 3Ophthalmology, Federal
University of São Paulo, São Paulo, Brazil;
4
Ophthalmology, Goethe University, Frankfurt,
Germany; 5Ophthalmology, Chang Gung Memorial
Hospital, Taoyuan, Taiwan; 6Ophthalmology, Keck
School of Medicine of the University of Southern
California, Los Angeles, CA *CR
2220 — A0089 Adipose-derived Stem
Cells (ADSCs) Delay the Process of Retinal
Degeneration in RCS Rats by Anti-apoptotic
Mechanisms. Zongyi Li1, 2, J. Wang1, 2, X. Shi2, J.
Zhang1, 2, L. Lu1, 2, W. Li1, 3, G. Xu1, 2. 1Department
of Ophthalmology of Shanghai Tenth People’s
Hospital, and Tongji Eye Institute, Tongji University
School of Medicine (TUSM), Shanghai, China;
2
Department of Regenerative Medicine and Stem
Cell Research Center, TUSM, Shanghai, China;
3
Department of Ophthalmology, Drexel University
College of Medicine, Philadelphia, PA
2221 — A0090 Differentiaiton of human
cord mesenchymal stem cells into retinal
cells in porcine retinal pigment epithelial cell
conditioned media. Haibin Tian1, 2, P. Li1, 2, L.
Wang1, 2, C. Lian1, 2, W. Wang1, 2, C. Jin1, 2, L. Lu1, 2,
W. Li1, 3, G. Xu1, 2. 1Department of Ophthalmology of
Shanghai Tenth Hospital, and Tongji Eye institute,
Tongji University School of Medicine (TUSM),
Shanghai, China; 2Department of Regenerative
Medicine and Stem Cell Research Center, TUSM,
Shanghai, China; 3Department of Ophthalmology,
Drexel University College of Medicine,
Philadelphia, PA
2222 — A0091 Characterization of a new
retinal cell line (MU-PH1) expressing stem cell
markers from adult mouse. Nicolas Cuenca1, V.
Gomez-Vicente1, A. Flores4, P. Lax1, C. Murciano4,
A. Yañez4, M. Gil4, D. Gonzalbo4, V. Maneu2, 3.
1
Physiology, Genetics and Microbiology, University
of Alicante SPAIN, Alicante, Spain; 2Optics,
Pharmacology and Anatomy, University of Alicante,
Alicante, Spain; 3Teófilo Hernando Institute of I+D
of drugs, University Autonoma of Madrid, Madrid,
Spain; 4Microbiology and Ecology, University of
Valencia, Valencia, Spain *CR
2223 — A0092 Retinal Neuron Derived from
WERI-Rb1 Improve Visual Function of RD1
and DBA/2J Mice. Jian Ge, Y. Liu, H. Hu, F.
Deng. Glaucoma, Zhongshan Ophthalmic Center,
Guangzhou, China
2224 — A0093 Somatic Epigenetic Memory in
iPSC-drived from Adult RPE. Shenghai Zhang,
J. Wu. Eye & ENT Hospital, Fudan University,
Shanghai, China
2225 — A0094 Generation Of iPSCs From
Adult Proliferating RPE Stem Cells. Barbara
Corneo1, T. A. Blenkinsop1, P. Lederman1, N.
C. Boles1, J. Saini1, G. Kusek1, S. D’Souza2, C.
Schaniel2, J. H. Stern1, S. Temple1. 1Neuroscience,
Neural Stem Cell Institute, Rensselaer, NY; 2Mount
Sinai School of Medicine, New York, NY *CR
2226 — A0095 Profiling endothelial progenitor
cells in adult blood. Panagiota Antonopoulou1, 2,
G. Kontos2, D. A. Sim2, J. Mckenzie2, M. Fruttiger2.
1
Ophthalmology, NHS Fife Queen Margaret
Hospital, Dunfermline, United Kingdom; 2Institute
of Ophthalmology, UCL, London, United Kingdom
*CR
2227 — A0096 Human Embyronic Stem Cell
Derived Polarized Retinal Pigment Epithelial
Cells have Higher Resistance to Oxidative
Stress-Induced Cell Death than Non-Polarized
Cultures. Jamie Hsiung2, 3, D. Zhu2, 3, D. R.
Hinton1, 3. 1Doheny Eye Institute, Los Angeles,
CA; 2Ophthalmology, Keck School of Medicine of
University of Southern California, Los Angeles,
CA; 3Pathology, Keck School of Medicine of
University of Southern California, Los Angeles,
CA *CR
2228 — A0097 Differential miRNA expression
profile of early passage iPS-RPE compared to
later passage iPS-RPE. Heuy-Ching H. Wang1,
A. Muniz1, 2, M. L. Plamper1, J. Choi1, 2, W. A.
Greene1, 2. 1Ocular Trauma, US Army Institute
of Surgical Research, Fort Sam Houston, TX;
2
National Research Council, Washington, DC
2229 — A0098 Effects of specific FGF
isoforms on retinal progenitor cell fate in a
human pluripotent stem cell model of retinal
development. Eric Clark1, K. Wallace1, D. Kuai1,
W. Shen1, J. Phillips1, 2, S. J. Dickerson4, M. Miller4,
R. Singh1, D. M. Gamm2, 3. 1Waisman Center,
University of Wisconsin, Madison, WI; 2McPherson
Eye Research Institute, University of Wisconsin,
Madison, WI; 3Department of Ophthalmology and
Visual Sciences, University of Wisconsin, Madison,
WI; 4Cellular Dynamics International, Inc.,
Madison, WI *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
168
Monday – Posters – 2230 – 2249
2230 — A0099 A Multiplex High Content High
Throughput Screening Platform Using iPS Cells
Derived RPE. Fnu Ruchi1, B. Corneo2, J. Davis1, B.
King1, Q. Wan1, K. J. Miyagishima1, S. Temple2, S.
S. Miller1, M. Ferrer1, K. Bharti1. 1NIH, Bethesda,
MD; 2Neural Stem Cell Institute, Rensselear, NY
*CR
2231 — A0100 The Potential of Limbal
Neurosphere Cells to Differentiate into Retinal
Cell Phenotypes. Xiaoli Chen, H. A. Thomson, P.
Hossain, A. J. Lotery. University of Southampton,
Southampton, United Kingdom *CR
2232 — A0101 In vitro differentiation of
human bone marrow-derived stem cells towards
retinogenic fate. Isai Mathivanan, J. Balmer, L.
Tamò, V. Enzmann. Department of Ophthalmology,
Inselspital, Bern, Switzerland
2234 — A0103 Feline Müller glia with stem cell
characteristics differentiate towards a retinal
ganglion cell phenotype in vitro. Karen Eastlake,
S. Becker, H. Jayaram, P. B. Cottrill, M. F. Jones,
G. Limb. Institute of Ophthalmology, UCL, London,
United Kingdom
2235 — A0104 Immunohistochemical And
Histopathological Characterisation of Allogenic
GFP+ Pig Retinal Progenitor Cells After
Transplantation Into the Sub-Retinal Space.
Murilo Abud1, 2, P. Y. Baranov1, C. Hicks3, S. Patel3,
J. Sinden3, C. V. Regatieri1, D. L. Isaac2, M. Ávila2,
M. J. Young1. 1Ophthalmology, Mass Eye and Ear/
Schepens Eye Institute / Harvard Medical School,
Boston, MA; 2Ophthalmology, Federal University
of Goiás, Goiania, Brazil; 3Reneuron, Guildford,
United Kingdom *CR
2236 — A0105 Differentiation of
retinoblastoma cancer stem cells as in vitro
model of optic nerve. Steve Brocchini1, 2, M.
M. Kuijten1, 2, A. Dahlmann-Noor1, P. T. Khaw1.
1
National Institute for Health Research (NIHR)
Biomedical Research Centre at Moorfields Eye
Hospital NHS Foundation Trust and UCL Institute
of Ophthalmology, London, United Kingdom; 2UCL
School of Pharmacy, London, United Kingdom *CR
2237 — A0106 Translational development of
human retinal progenitor cells for treatment
of retinitis pigmentosa. Jing Yang1, G. P. Lewis2,
B. Lu3, N. Turovets1, G. Luna2, S. Girman3, G.
Bauer4, S. K. Fisher2, S. Wang3, H. J. Klassen1.
1
Ophthalmology, University of California Irvine,
Irvine, CA; 2University of California, Santa
Barbara, Santa Barbara, CA; 3Cedears-Sinai
Medical Center, Los Angeles, CA; 4University of
California, Davis, Sacramento, CA *CR
2239 — A0108 Vascular Endothelial Growth
Factor (VEGF) induced proliferation of human
fetal derived ciliary epithelium stem cells is
mediated by Jagged - N Cadherin pathway.
Akshay Anand1, C. Abburi1, S. Prabhakar1, J.
Kalra2, A. Huria3. 1Neurology, Post Graduate
Institute of Medical Education and Research,
Chandigarh, India; 2Obstetrics & Gynaecology,
Post Graduate Institute of Medical Education
and Research, Chandigarh, India; 3Obstetrics &
Gynaecology, Government Medical College and
Hospital, Chandigarh, India
2240 — A0109 Differentiation of Retinal
Ganglion Cells from Induced Pluripotent Stem
Cells. Binbin Xie1, X. Zhang2, T. Hashimoto2,
A. Tien2, A. Chen2, J. Ge1, X. Yang2. 1State Key
Laboratory of Ophthalmology, Zhong-Shan
Ophthalmic Center, Sun Yat-Sen University,
Guangzhou, China; 2Jules Stein Eye Institute,
University of California, Los Angeles, Los Angeles,
CA
2241 — A0110 Differentiation and
transplantation of mouse ESC- and iPSCderived retina-like sheets in retinal degeneration
mouse. Juthaporn Assawachananont1, M.
Mandai1, J. Kaneko1, S. Okamoto1, C. Yamada1, M.
Eiraku2, Y. Sasai2, M. Takahashi1. 1Lab for Retina
Regeneration, Riken Ctr for Developmtl Biol,
Kobe, Japan; 2Organogenesis and Neurogenesis
Group, Riken Center for Developmental Biology,
Kobe, Japan
2242 — A0111 A new method for subretinal
transplantation of human adult stem cells
preserves retinal structure along the entire
retina and rescues retinal function in a rat model
of retinal dystrophies. Ifat Sher-Rosenthal1, A.
Tzameret1, M. Belkin1, A. J. Treves2, A. Nagler3, Y.
Rotenstreich1. 1Goldschleger Eye Research Institute,
Sheba Medical Center, Tel Hashomer, Israel;
2
Cancer Reserch Center, Sheba Medical Center, Tel
Hashomer, Israel; 3Hematology Division, Sheba
Medical Center, Tel Hashomer, Israel *CR
2243 — A0112 Retinal Ganglion Cell
Transplantation After Optic Nerve Injury.
BO QU1, 2, J. Hertz1, R. D. Patel1, Y. Wang1, J.
L. Goldberg1. 1Bascom Palmer Eye Institute and
Interdisciplinary Stem Cell Institute, University of
Miami, miami, FL; 2The 4th Affiliated Hospital of
China Medical University, Shenyang, China
2244 — A0113 Maturation of Stem Cell
Derived Retinal Pigment Epithelium Changes Its
Electrophysiological Properties. Soile Nymark1,
K. M. Juuti-Uusitalo2, H. Skottman2, J. Hyttinen1.
1
Department of Biomedical Engineering, Tampere
University of Technology, Tampere, Finland;
2
Institute of Biomedical Technology, University of
Tampere, Tampere, Finland
Exhibit Hall B0049-B0103
Monday, May 06, 2013 2:45 PM-4:30 PM
Glaucoma
286 Structure and Function II
Moderator: Linda M. Zangwill
2245 — B0049 Longitudinal Assessment of
Retinal Ganglion Cell Degeneration In Vivo.
Gustavo C. Munguba, D. Lam, L. Ge, S. Galeb, S.
Samad, M. L. Tapia, A. Camp, X. Xing, R. K. Lee.
Ophthalmology, University of Miami BPEI, Miami,
FL *CR
2246 — B0050 Lamina Cribrosa Position and
Superior Visual Field Loss in Glaucoma. Yiyi
Liu1, 3, S. Park1, 2, R. L. Furlanetto1, C. F. Netto1,
U. J. Damle4, J. M. Liebmann1, 5, R. Ritch1, 2.
1
Moise and Chella Safra Advanced Ocular Imaging
Laboratory, Einhorn Clinical Research Center,
New York Eye and Ear Infirmary, New York, NY;
2
Department of Ophthamology, New York Medical
College, Valhalla, NY; 3New York Medical College,
Valhalla, NY; 4Robert Wood Johnson Medical
School, New Brunswick, NJ; 5Department of
Ophthamology, New York University School of
Medicine, New York, NY *CR
2247 — B0051 Between-Subject Differences
Account for More Dissociation Between Rim
Area and Visual Sensitivity Than WithinSubject Fluctuations. Iván Marín-Franch1, 2,
W. H. Swanson1. 1School of Optometry, Indiana
University, Bloomington, IN; 2Optometry and
Visual Science, City University London, London,
United Kingdom
2248 — B0052 A Test of a Schematic Model of
Glaucomatous Damage of the Macula. Donald
C. Hood1, A. S. Raza2, I. Traynis3, C. De Moraes4,
J. M. Liebmann4, 5, R. Ritch5, 6. 1Psychology and
Ophthalmology, Columbia University, New York,
NY; 2Neurobiology and Behavior, Columbia
University, New York, NY; 3School of Medicine,
Tufts University, Boston, MA; 4Ophthalmology,
NYU School of Medicine, New York, NY; 5Einhorn
Clinical Research Center, New York Eye & Ear
Infirmary, New York, NY; 6Ophthalmology, New
York Medical College, Valhalla, NY *CR
2249 — B0053 Ganglion cell complex and
peripapillary RNFL alterations in patients with
open angle glaucoma. Monica Mosca, A. Rossi, R.
Sala, R. Ratiglia. Eye Clinic, Fondazione IRCCS
“Cà Granda - Ospedale Maggiore Policlinico”,
Milano, Italy
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
169
Monday Posters
2:45 pm – 4:30 pm
2233 — A0102 RGC differentiation from ES
cells: Influence of FGF2 and Notch signalling.
Divya Sivaraman1, 2, A. Vazhanthodi1, S. Hattar2,
J. James1. 1Neurobiology, Rajiv Gandhi Centre for
Biotechnology, Trivandrum, India; 2Biology, Johns
Hopkins University, Baltimore, MD
2238 — A0107 Aquaporin expression and
function in human pluripotent stem cell
-derived retinal pigment epithelial cells. Kati
M. Juuti-Uusitalo1, C. Delporte2, F. Gregoire2, J.
Perret2, V. Savolainen3, S. Nymark3, J. Hyttinen3,
H. M. Uusitalo4, 5, F. Willermain6, H. Skottman1.
1
Institute of Biomedical Technology, University
of Tampere, Tampere, Finland; 2Laboratory of
Pathophysiological and Nutritional Biochemistry,
Université Libre de Bruxelles, Brussels, Belgium;
3
Department of Biomedical Engineering, Tampere
University of Technology, Tampere, Finland; 4SILK
Department of Ophthalmology, University of
Tampere, Tampere, Finland; 5Eye Center, Tampere
University Hospital, Tampere, Finland; 6Department
of Ophthalmology, CHU St Pierre and Brugmann
and I.R.I.B.H.M, Brussels, Belgium
Monday Posters
2:45 pm – 4:30 pm
2250 – 2270 – Monday – Posters
2250 — B0054 Platelet Function Influences on
Disc Hemorrhages in Patients with Open-Angle
Glaucoma. Seonghee Shim1, J. Kim1, C. Choi1, K.
Park2. 1Ophthalmology, Sungkyunkwan University
School of Medicine, Kangbuk Samsung Hospital,
Seoul, Republic of Korea; 2Ophthalmology, Seoul
National University College of Medicine, Seoul,
Republic of Korea
2257 — B0061 Maps Relating OCT Retinal
Nerve Fiber Layer to Visual Fields Influence
Evaluations of Structure-Function Models. Ali
S. Raza1, 2, D. C. Hood1, 3. 1Psychology, Columbia
University, New York, NY; 2Neurobiology and
Behavior, Columbia University, New York, NY;
3
Ophthalmology, Columbia University, New York,
NY *CR
2251 — B0055 Diagnostic Innovations in
Glaucoma Study (DIGS): Relationship between
Disease Severity and Reproducibility of
Estimated Number of Retinal Ganglion Cells
in Glaucoma. Amir Marvasti1, 2, R. Lisboa1, 3, L.
M. Zangwill1, R. N. Weinreb1, F. A. Medeiros1.
1
Hamilton Glaucoma Center, Department of
Ophthalmology, University of California, San
Diego, San Diego, CA; 2Boston University,
School of Medicine, Boston, MA; 3Department of
Ophthalmology, Federal Univ of São Paulo, São
Paulo, Brazil *CR, f
2258 — B0062 A Novel Method Of Measuring
Optic Disc Tilt. Seng-Chee Loon1, 2, V. Koh1, 2,
W. Wong2, X. LI2, T. Y. Wong1, 2, T. Aung3, 2, P. R.
Healey4. 1Ophthalmology, National University
Hospital of Singapore, Singapore, Singapore;
2
Eye, Singapore Eye Research Institute, Singapore,
Singapore; 3Eye, Singapore National Eye Centre,
Singapore, Singapore; 4Ophthalmology, University
of Sydney, Sydney, NSW, Australia *CR, f
2252 — B0056 Acute systemic hemodynamic
effects on intraocular pressure in rats with
unilateral experimental ocular hypertension.
Jonathan C. Li1, V. Gupta1, Y. You1, K. Ng1, S.
Graham1, 2. 1Department of Ophthalmology and
Visual Sciences, Australian School of Advanced
Medicine, Macquarie University, Sydney, NSW,
Australia; 2Save Sight Institute, Sydney University,
Sydney, NSW, Australia
2253 — B0057 Glaucoma Severity Correlates
with Lamina Cribrosa Depth and Thickness.
Martha Kim, K. D. Bojikian, D. Choi, M. A.
Slabaugh, P. P. Chen. Ophthalmology, University of
Washington School of Medicine, Seattle, WA *CR
2254 — B0058 Inter-ethnicity Comparison
of Anterior Chamber Biometry and Iris
Measurements between Narrow Angle and
Open Angle Cohorts Using ASOCT. Ye Elaine
Wang1, 2, Y. LI1, 3, D. Wang1, 4, M. He4, S. C. Lin1.
1
Ophthalmology, University of California, San
Francisco, San Francisco, CA; 2Duke University
School of Medicine, Durham, NC; 3Ophthalmology,
Number Third Affiliated Hospital of Nanchang
University, Nanchang, China; 4State Key Laboratory
of Ophthalmology, Zhongshan Ophthalmic Center,
Sun Yat-sen University, Guangzhou, China
2255 — B0059 Comparison of Regression
Analysis in structural and functional monitoring
of glaucoma patients. Gijs Thepass1, J. van der
Schoot1, K. A. Vermeer1, H. G. Lemij1, 2. 1Rotterdam
Ophthalmic Institute, Rotterdam Eye Hospital,
Rotterdam, Netherlands; 2Glaucoma Service,
Rotterdam Eye Hospital, Rotterdam, Netherlands
*CR, f
2256 — B0060 Evaluation of filtering blebs
with transconjunctival oozing by anterior
segment optical coherence tomography.
Nakashima Kei-Ichi, T. Inoue, A. Fukushima, H.
Saori, T. Kawaji, H. Tanihara. Department of
Ophthalmology, Kumamoto University, Faculty of
Life Sciences, Kumamoto, Japan
2259 — B0063 Three-Dimensional (3-D)
Histomorphomety of Normal Human Optic
Nerve Head (ONH) Connective Tissue at
physiologic and elevated IOP. Lan Wang1, H.
Yang2, M. A. Fazio1, B. Smith1, C. C. Cheetham1,
J. C. Downs1, J. Reynaud2, H. Lockwood2, C. F.
Burgoyne2, C. A. Girkin1. 1Ophthal-CEFH, Univ
of Alabama at Birmingham, Birmingham, AL;
2
Discoveries in Sight, Devers Eye Institute, Legacy
Research Institute, Portland, OR *CR
2260 — B0064 Longitudinal analysis of
progression in Korean patients with normal
tension glaucoma. Sun Hee Lim, Y. Park, K. Choi.
Ophthalmology, Ewha Womans University School
of Medicine, Seoul, Republic of Korea
2261 — B0065 Symmetry of the Pupillary
Light Reflex and its Relationship to Retinal
Nerve Fiber Layer Thickness and Visual Field
Defect in Subjects With and Without Glaucoma.
Dolly S. Chang1, 2, K. S. Arora1, M. V. Boland1,
D. S. Friedman1, 2. 1Ophthalmology, Wilmer Eye
Institute, Johns Hopkins University, Baltimore, MD;
2
Epidemiology, Bloomberg School of Public Health,
Johns Hopkins University, Baltimore, MD *CR
2262 — B0066 Trabeculectomy bleb assessment
via three-dimensional anterior segment optical
coherence tomography. Takahiro Kawaji, T. Inoue,
R. Matsumura, U. Kuroda, N. Kei-Ichi, H. Tanihara.
Ophthalmology, Kumamoto University, Chuo-ku,
Kumamoto, Japan
2263 — B0067 Visual and structural prognosis
of the untreated fellow eyes of unilateral
normal tension glaucoma patients. Hyun-kyung
Cho1, J. Han1, W. Suh2, C. Kee1. 1Department
of Ophthalmology, Samsung Medical Center,
Sungkyunkwan University School of Medicine,
Seoul, Republic of Korea; 2Department of
Ophthalmology, Hallym Sacred Heart Hospital,
College of Medicine, University of Hallym,
Anyang, Republic of Korea
2264 — B0068 Determinants of angle
narrowing after mydriasis. Syogo Arimura, Y.
Takamura, T. Tomomatsu, Y. Takihara, M. Inatani.
Ophthalmology, University of Fukui, Yoshida,
Japan f
2265 — B0069 Quantification of the filtering
bleb’s structure using Anterior segment optical
coherence tomography. Taiki Kokubun, S. Tsuda,
Y. Shiga, Y. Yokoyama, K. Omodaka, R. Watanabe,
M. Ryu, S. Kunimatsu-Sanuki, H. Takahashi, T.
Nakazawa. Ophthalmology, Tohoku University
Graduate School of Medicine, Sendai, Japan *CR
2266 — B0070 An optical coherence
tomographic study of macular ganglion cell layer
and inner plexiform layer, and circumpapillary
retinal nerve fiber layer in 2 years after
a diagnosis of preperimetric glaucoma.
Kazuhide Kawase1, H. Inuzuka2, 1, T. Yamamoto1.
1
Ophthalmology, Gifu University, Gifu, Japan;
2
Ophthalmology, Gifu Municipal Hospital, Gifu,
Japan *CR
2267 — B0071 Effect of experimental glaucoma
on the visual pathway function and superior
colliculus glial structure. Melina P. Bordone, M.
González Fleitas, R. E. Rosenstein. Department
of Human Biochemistry, School of Medicine,
University of Buenos Aires/CEFYBO, CONICET,
Buenos Aires, Argentina
2268 — B0072 Non-Invasive Estimation of
Intracranial Pressure by Magnetic Resonance
Imaging Assisted Orbital Subarachnoid Space
Measurement: The Beijing Intracranial and
Intraocular Pressure (iCOP) Study. Xiaobin
Xie2, 1, N. Wang1, X. Zhang3, J. B. Jonas4, J. Xian5,
R. Ritch6, 7. 1Beijing Tongren Eye Center, Beijing
Tongren Hospital, Capital Medical University,
Beijing Ophthalmology and Visual Sciences Key
Laboratory, Beijing, China; 2Ophthalmology, Eye
Hospital of China Academy of Chinese Medical
Sciences, Beijing, China; 3Neurology, Beijing
Tongren Hospital, Capital Medical University,
Beijing, China; 4Ophthalmology, Medical Faculty
Mannheim of the Ruprecht-Karls-University
Heidelberg, Mannheim, Germany; 5Radiology,
Beijing Tongren Hospital, Capital Medical
University, Beijing, China; 6Einhorn Clinical
Research Center, New York Eye and Ear Infirmary,
New York, NY; 7Department of Ophthalmology,
New York Medical College, Valhalla, NY *CR, f
2269 — B0073 Measurement of minimum rim
width (MRW) using Cirrus Optic Nerve Head
Volumes in a Chinese Population. Chen-Hsin
Sun1, T. A. Tun2, J. S. de Leon2, M. J. Girard3, 5, T.
Aung2, N. G. Strouthidis4, 2. 1Duke-NUS Graduate
Medical School, Singapore, Singapore; 2Glaucoma,
Singapore National Eye Center, Singapore,
Singapore; 3Bioengineering, National University
of Singapore, Singapore, Singapore; 4Glaucoma
Research Unit, NIHR Biomedical Research Centre
at Moorfields Eye Hospital NHS Foundation Trust
and UCL Institute of Ophthalmology, London,
United Kingdom; 5Singapore Eye Research
Institute, Singapore, Singapore *CR
2270 — B0074 Optic nerve head (ONH)
connective tissue (CT) deformation within NonHuman Primate (NHP) eyes with moderate to
severe (M/S) Experimental Glaucoma (EG).
Galen Williams1, R. Ren1, H. Yang1, J. C. Downs2,
S. K. Gardiner1, C. F. Burgoyne1. 1Discoveries in
Sight Research Laboratories, Devers Eye Institute,
Portland, OR; 2Ophthalmology, University of
Alabama at Birmingham, Birmingham, AL *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
170
Monday – Posters – 2271 – 2292
2271 — B0075 Reproducibility of Peripapillary
Choroidal Thickness Measurements with
Enhanced Depth Imaging Spectral-Domain
Optical Coherence Tomography. Paula D. Borba,
V. G. Prado, P. D. Silva, I. Matsubara, T. S. Prata,
R. M. Vessani, A. Paranhos. Departamento de
Oftalmologia, Universidade Federal de Sao Paulo,
Sao Paulo, Brazil *CR
2272 — B0076 In Vivo Identification of
Laminar and Pre-laminar ONH Structures using
Enhanced Depth Imaging Spectral-Domain
Optical Coherence Tomography. Paula D. Silva,
V. G. Prado, P. D. Borba, I. Matsubara, R. M.
Vessani, A. Paranhos, T. S. Prata. Ophthalmology,
Federal University of Sao Paulo, Sao Paulo, Brazil
*CR
2274 — B0078 The Prevalence of Relative
Afferent Pupillary Defects in Patients with
Normal Visual Fields. Alice Zhang1, 2, L. Lu2,
M. Ali2, B. M. Faria2, P. Martinez2, L. Liang2, H.
Guzel2, M. A. Tawfik2, G. L. Spaeth2. 1Jefferson
Medical College, Philadelphia, PA; 2Glaucoma
Research, Wills Eye Institute, Philadelphia, PA *CR
2275 — B0079 Retinal nerve fiber layer and
posterior pole asymmetry analysis by spectral
domain-OCT: structure function relationship
with visual field sensitivity in glaucoma. Manuele
Michelessi1, M. Centofanti2, 1, F. Oddone2, L. Tanga2,
D. Iannetta1, P. Pasculli1, M. Ferrazza2, G. Manni1.
1
University of Rome Tor Vergata, Rome, Italy;
2
Fondazione G.B. Bietti-IRCCS, Rome, Italy *CR
2276 — B0080 Rates of functional and
structural change are significantly correlated in
eyes with early to moderate glaucoma. Shaban
Demirel, L. Deng, D. Goren, M. Pathak, S. L.
Mansberger, B. Fortune, S. K. Gardiner. Devers
Eye Institute, Legacy Health, Portland, OR *CR
2277 — B0081 Pressure Induced Changes
in the Human Optic Nerve Head assessed by
Immunofluorescent Computed Tomography
(ICT). Donald J. Brown, G. J. Parfitt, K. Reeid,
Y. Xie, J. V. Jester. Gavin Herbert Eye Institute,
University of California, Irvine, Ivine, CA
2278 — B0082 Comparison between
peripapillary choroidal thickness and retinal
nerve fiber layer (RNFL) damage in healthy,
ocular hypertension and glaucomatous eyes.
Emanuele Gerace, A. Cutini, S. Fragiotta, M.
Marenco, F. Verboschi, C. Carnevale, E. M.
Vingolo. Department of Ophthalmology, Sapienza University of Rome, Rome, Italy
2280 — B0084 Agreement between the
Heidelberg Edge perimetry and the Moorfields
regression analysis classifications in healthy
and glaucoma individuals. Blanca Monsalve1,
A. Ferreras2, M. Ara2, S. Otin2, C. Cortes1.
1
Ophthalmology, Hospital Univ Gregorio Marañón,
Madrid, Spain; 2Ophthalmology, Miguel Servet
University Hospital, Zaragoza, Spain *CR
2281 — B0085 Combining Nerve Fiber Layer
and Ganglion Cell Complex Parameters for
Glaucoma Diagnosis using Fourier-Domain
Optical Coherence Tomography. Xinbo Zhang1,
O. Tan1, R. Varma4, 5, J. S. Schuman3, D. S.
Greenfield2, D. Huang1. 1Cassey Eye Institute,
Oregon Health & Science University, Portland,
OR; 2Bascom Palmer Eye Institute, University of
Miami, Miami, FL; 3Ophthalmology, University
of Pittsburgh, Pittsburgh, PA; 4Ophthalmology,
University of Southern California, Los Angeles,
CA; 5Illinois Eye and Ear Infirmary, University of
Illinois at Chicago, Chicago, IL *CR, f
2282 — B0086 Comparison of Retinal Nerve
Riber Layer and Optic Disk Algorithms with
Optical Coherence Tomography with 10 degree
of head rotation. Rafael Castañeda Diez, L. A.
Zarate, J. Jimenez-Roman. Glaucoma, Asociacion
Para Evitar la Ceguera, Mexico City, Mexico
2283 — B0087 Correlation between
peripapillary retinal nerve fiber layer thickness
and visual field defect in glaucoma. Andre Luiz
Silva, L. S. Melo, M. Campos, I. M. Tavares.
Ophthalmology, Federal University of Sao Paulo,
Sao Paulo, Brazil
2284 — B0088 Relationship between the mean
deviation of the visuald field (Humphrey) and
the analysis of the retinal fiber layer thickness of
the optical coherence tomography (Stratus OCT)
for moderates and severes glaucomatous eyes.
Idriss Badat1, E. Dumas de La Roque1, M. Mercie1,
B. Tougeron1, N. Yani1, N. Bouamama1, J. Morin2,
P. Ingrand1, M. Boissonnot1, N. Leveziel1. 1Service
d’ophtalmologie, CHU La Milétrie, Poitiers,
France; 2Département d4ophtalmologie, Hopital
Rosemond-Maisonneuve, Montréal, QC, Canada
2285 — B0089 Myopia in Primary Angle
Closure Glaucoma. Kailing Yong1, T. Gong2, M.
E. Nongpiur1, 3, H. Lee2, L. Cheng2, S. Perera1,
T. Aung1, 4. 1Singapore National Eye Centre and
Singapore Eye Research Institute, Singapore,
Singapore; 2Bioinformatics Institute, A*STAR
(Agency for Science, Technology and Research),
Singapore, Singapore; 3Duke-NUS Graduate
Medical School, Singapore, Singapore; 4Yong Loo
Lin School of Medicine, National University of
Singapore, Singapore, Singapore *CR
2286 — B0090 Comparison between deviation
map of circumpapillary retinal nerve fiber layer
and macular ganglion cell-inner plexiform layer
measurements using high-definition optical
coherence tomography in the detection of early
glaucoma. Yun Jeong Choi1, 2, M. Kim1, 2, K. Kim1, 2,
J. Jeoung1, 2, K. Park1, 2, D. Kim1, 2. 1Ophthalmology,
Seoul National University College of Medicine,
Seoul, Republic of Korea; 2Ophthalmology, Seoul
National University Hospital, Seoul, Republic of
Korea
2287 — B0091 Reproducibility of the
measurement of Optic Nerve Head Hemoglobin
levels. Carmen Mendez-Hernandez1, I. RodriguezUña1, P. Arribas Pardo1, F. Saenz-Frances1, M.
González-de-la-Rosa2, J. M. Martinez de la Casa1,
E. Santos-Bueso1, J. Garcia-Feijoo1. 1Glaucoma,
Instituto de Investigación Sanitaria San Carlos
(IdISSC) Fundación de Investigación Biomédica
del Hospital Clínico San Carlos, Madrid, Spain;
2
Hospital Universitario de Canarias., La Laguna,
Spain *CR, f
2288 — B0092 Macular Ganglion Cell
Imaging Study: Glaucoma Diagnostic Accuracy
of Spectral-Domain Optical Coherence
Tomography. Jin Wook Jeoung1, Y. Choi1, S. Kim2,
K. Park1, D. Kim1. 1Department of Ophthalmology,
Seoul National University Hospital, Seoul National
University College of Medicine, Seoul, Republic
of Korea; 2Department of Ophthalmology, Seoul
National University Boramae Hospital, Seoul,
Republic of Korea
2289 — B0093 Relationship between Axonal
Subtypes and Size of Retinal Nerve Fiber
Bundles. Ye Zhou1, 2, X. Zhao2, X. Huang2, 1.
1
Biomedical Engineering, University of Miami,
Miami, FL; 2Ophthalmology, Miller School of
Medicine, University of Miami, Miami, FL
2290 — B0094 Determination of Optic Disc
Hemoglobin Quantity in Ocular Hypertension,
Compared With Optical Coherence Tomography.
Paula Arribas Pardo1, J. Garcia-Feijoo1, M.
González-de-la-Rosa2, I. Rodriguez-Uña1, C.
Berrozpe Villabona1, F. Saenz-Frances1, J. M.
Martinez de la Casa1, E. Santos-Bueso1, C. MendezHernandez1. 1Glaucoma. Instituto de Investigación
Sanitaria San Carlos (IdISSC) Fundación de
Investigación Biomédica del Hospital Clínico San
Carlos, Madrid, Spain., Madrid, Spain; 2Hospital
Universitario de Canarias., La Laguna, Spain
*CR, f
2291 — B0095 The Relationship Between
Morphological Changes and Reduction of Active
Areas of Aqueous Outflow in Eyes with Primary
Open Angle Glaucoma. Elliot D. Cha, R. Jin, H.
Gong. Ophthalmology, Boston University School of
Medicine, Boston, MA
2292 — B0096 A Novel Rat Model to Study
the Role of Intracranial Hypotension in Optic
Neuropathy. Uttio Roy Chowdhury, B. H.
Holman, C. R. Hann, C. K. Bahler, M. P. Fautsch.
Ophthalmology, Mayo Clinic, Rochester, MN
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
171
Monday Posters
2:45 pm – 4:30 pm
2273 — B0077 Descriptive study of the
anterior chamber angle using anterior segment
Fourier Domain OCT and its relationship to
the morphometry of the eye in the normal
population. José Ignacio Fernández-Vigo1, C.
Fernandez-Vigo Escribano3, J. García Bella1, J.
M. Martinez de la Casa1, J. Garcia-Feijoo1, J.
Fernández-Vigo López2. 1Ophthalmology, Hospital
Clinico San Carlos, Madrid, Spain; 2CIOA Universidad de Extremadura, Badajoz, Spain;
3
Centro de Oftalmologia Barraquer, Barcelona,
Spain *CR
2279 — B0083 Comparison of the strengths
of ‘moving correlations’ between SD-OCT and
SLP nerve fiber layer thickness and standard
automated perimetry. Casie Goldman, S. Demirel,
C. L. Blachly, M. D. Whitworth, S. L. Mansberger,
S. K. Gardiner, D. Goren. Devers Eye Institute,
Legacy Research Institute, Portland, OR *CR
2293 – 2313 – Monday – Posters
2293 — B0097 Effect of Pupil Dilation on Angle
Metrics Obtained from Spectral-Domain Optical
Coherence Tomography (SD-OCT). Xiaojing
Pan, V. Chopra, B. A. Francis, Z. Yuan Zhang, M.
Nittala, J. Maram, L. V. Fou, P. W. Romano, C. J.
Barnett, S. Sadda. Doheny Eye Institute, University
of Southern California, Los Angeles, CA *CR
Monday Posters
2:45 pm – 4:30 pm
2294 — B0098 Structure and function in
multifocal pupillographic objective perimetry
(mfPOP). Maria Kolic1, 2, A. Y. Chain3, A. C.
James1, 2, T. Maddess1, 2, C. F. Carle1, 2. 1ARC CoE
in Vision Science, Australian National University,
Canberra City, ACT, Australia; 2Eccles Institute
of Neuroscience, Australian National University,
Canberra, ACT, Australia; 3ANU Medical School,
Australian National University, Canberra City, ACT,
Australia *CR
2295 — B0099 Continuous Likelihood Ratios
for Glaucoma Diagnosis Using the Combined
Index of Structure and Function. Tammy TungMei Kuang1, 2, R. Lisboa1, 3, A. J. Tatham1, L. M.
Zangwill1, R. N. Weinreb1, J. M. Liebmann4, 5,
C. A. Girkin6, N. Khachatryan1, N. Hammel1, F.
A. Medeiros1. 1Department of Ophthalmology,
Hamilton Glaucoma Center, California, CA;
2
Department of Ophthalmology, Taipei Veterans
General Hospital, Taipei, Taiwan; 3Department of
Ophthalmology, Federal University of São Paulo,
São Paulo, Brazil; 4School of Medicine, New
York University, New York, NY; 5Department of
Ophthalmology, Einhorn Clinical Research Center,
New York Eye and Ear Infirmary, New York, NY;
6
School of Medicine, University of Alabama,
Birmingham, AL *CR, f
2296 — B0100 The Geometric Factors related
to Central Visual Field Defect in Normal
Tension Glaucoma. Hyungyu Yoo, M. Lee, J. Ahn.
Department of Ophthalmology, Ajou University
School of Medicine, Suwon, Republic of Korea
2297 — B0101 Evaluation of Optic Nerve
Head for Diagnosis Of Glaucoma in Cadaver
Eyes Without Prior History. Srinivasan
Senthilkumari1, M. Neethu2, R. Santhi3, S.
Krishnadas4, V. Muthukkaruppan5. 1Department of
Ocular Pharmacology, Aravind Medical Research
Foundation, Madurai, India; 2Glaucoma Clinic,
Aravind Eye Hospital, Madurai, India; 3Department
of Pathology, Aravind Medical Research
Foundation, Madurai, India; 4Glaucoma Clinic,
Aravind Eye Hospital, Madurai, India; 5Department
of Immunology and Cell Biology, Aravind Medical
Research Foundation, Madurai, India
2298 — B0102 Diagnostic power of the new
colorimetry photographic device (Laguna
ONhE) in glaucomatous and hypertensive
eyes: comparative study with Spectralis optical
coherence tomography and HRT III confocal
tomography. Ignacio Rodriguez-Uña1, C. MendezHernandez1, M. González-de-la-Rosa2, F. SaenzFrances1, P. Arribas Pardo1, J. M. Martinez de
la Casa1, J. Garcia-Feijoo1. 1Glaucoma, Instituto
de Investigación Sanitaria San Carlos (IdISSC)
Fundación de Investigación Biomédica del Hospital
Clínico San Carlos, Madrid, Spain; 2Hospital
Universitario de Canarias, La Laguna, Spain
*CR, f
2299 — B0103 Three-dimensional quantitative
analysis of collagen fibre architecture in human
peripapillary sclera. Jacek K. Pijanka1, T.
Sorensen2, T. D. Nguyen3, H. Quigley4, C. Boote1.
1
Structural Biophysics, School of Optometry
and Vision Sciences, Cardiff University, Cardiff,
United Kingdom; 2Diamond Light Source, Didcot,
United Kingdom; 3The Department of Mechanical
Engineering, The Johns Hopkins University,
Baltimore, MD; 4Glaucoma Centre of Excellence,
Wilmer Ophthalmological Institute, Johns Hopkins
University School of Medicine, Baltimore, MD *CR
Exhibit Hall B0244-B0270
Monday, May 06, 2013 2:45 PM-4:30 PM
Multidisciplinary Ophthalmic Imaging
287 Imaging Technologies and
Applications
Moderator: Cynthia A. Toth
2300 — B0244 Comparison of intraoperative
refraction measured by ORA wavefront
aberrometer and postoperative refraction after
cataract surgery. Maria Rahman1, A. Yeh2, N.
Hord2, M. X. Wang2, R. Yang2, A. Waymire2, B.
Brown2. 1Saint James School of Medicine, The
Valley, Anguilla; 2Wang Vision Institute, Nashville,
TN
2301 — B0245 An Anatomically Correct
Widefield Phantom for Retinal Optical
Coherence Tomography. Anthony T. Corcoran1, 2,
G. Muyo2, J. van Hemert2, S. Pemberton2, A.
Harvey1. 1Physics and Astronomy, University of
Glasgow, Glasgow, United Kingdom; 2Research,
Optos Plc, Dunfermline, United Kingdom *CR
2305 — B0249 Relationship of Pre-orbital and
Orbital Volume to Blowout Fractures. Emile
Sharifi1, T. Le2, K. Howe1, L. M. Mitsumori3, A.
Jian-Amadi1. 1Department of Ophthalmology,
Univ of Washington, Seattle, Seattle, WA; 2School
of Medicine, University of Washington, Seattle,
WA; 3Department of Radiology, University of
Washington, Seattle, WA
2306 — B0250 Remote Observer Rapid
Cataract Screening Based on Fundus Photo.
Ann Choi1, 2, D. Hjelmstad3, 2, J. N. Taibl2, 1, K.
Martin2, S. I. Sayegh2. 1University of Illinois
Urbana Champaign, Urbana, IL; 2The EYE Center,
Champaign, IL; 3Arizona State University, Metro
Phoenix, AZ
2307 — B0251 Imaging stimulus-evoked
reflectance changes in human retina. Daniel Y.
Tso1, 2, Q. Du1, 2, R. Miller1, 3. 1Dept of Neurosurgery,
SUNY Upstate Medical Univ, Syracuse, NY;
2
SUNY Eye Institute (SEI), Syracuse, NY; 3SUNY
Binghamton, Binghamton, NY
2308 — B0252 A New Miayake-Apple view
using nasal endoscope. Ho Sik Hwang, J. Won, J.
Paik, S. Yang. Department of Ophthalmology, Seoul
St Mary’s Hospital, Seoul, Republic of Korea
2309 — B0253 Injuries to the Globe: A
Combined Radiographic and Clinical Approach.
Anastasia Traband, R. Ghafouri. Boston University
Medical Center, Boston, MA
2310 — B0254 Histologic Confirmation of
High Resolution MRI Ocular Imaging. James
P. Bolling1, P. Foroutan2, D. R. Salomao1, Z. K.
Wszolek1, G. V. Martinez2. 1Ophthalmology, Mayo
Clinic, Jacksonville, FL; 2Research, Moffit Cancer
Center, Tampa, FL
2302 — B0246 Ultrasonographic differentiation
of avulsed retinal vessels presenting with vitreous
hemorrhage after trauma. Maria E. Bretana1,
E. N. Kegley3, A. C. Schefler2. 1Ophthalmic
Echography, Retinal Consultants of Houston,
Houston, TX; 2Ophthalmology, Retinal Consultants
of Houston, Houston, TX; 3Photography, Retinal
Consultants of Houston, Houston, TX
2311 — B0255 In Vivo Human Eye Magnetic
Resonance Imaging at 7.0 Tesla in Volunteers
and Patients: Preliminary data. Oliver Stachs1, J.
Rieger2, P. Krueger3, S. Hadlich3, A. Pohlmann2, T.
Niendorf2, R. F. Guthoff1, S. Langner3. 1Department
of Ophthalmology, University of Rostock, Rostock,
Germany; 2Berlin Ultrahigh Field Facility, MaxDelbrück Center for Molecular Medicine, Berlin,
Germany; 3Department of Radiology, Ernst-MoritzArndt University Greifswald, Greifswald, Germany
*CR
2303 — B0247 Project MACULA
(MACulopathy Unveiled by Laminar Analysis):
a website of AMD histopathology. Kenneth
R. Sloan1, L. Hannon1, J. D. Messinger2, C. A.
Curcio2. 1Computer and Information Science,
UAB, Birmingham, AL; 2Ophthalmology, UAB,
Birmingham, AL
2312 — B0256 Congenital Bilateral Absence
of the Abducens Nerve. Lauren C. Ditta1, A. F.
Choudhri2, 3, M. Hoehn1. 1Ophthalmology, Hamilton
Eye Institute, Memphis, TN; 2Radiology, University
of Tennessee Health Science Center, Memphis,
TN; 3Radiology, Le Bonheur Children’s Hospital,
Memphis, TN
2304 — B0248 Polarimetry in ex vivo
retina from donors with Alzheimer’s disease.
Francisco Avila1, 3, L. Emptage1, M. L. Kisilak1, 2,
J. M. Bueno3, M. C. Campbell1, 2. 1Physics and
Astronomy, University of Waterloo, Waterloo, ON,
Canada; 2School of Optometry and Vision Science,
University of Waterloo, Waterloo, ON, Canada;
3
Laboratorio de Optica, Centro de Investigacion
en Optica y Nanofisica, Universidad de Murcia,
Murcia, Spain *CR
2313 — B0257 Postmortem Imaging of the
Posterior Segment of Eyes with Histopathologic
Correlation. Timothy Saunders1, P. Gore2, N.
Sprehe2, P. R. Pavan1, C. E. Margo1. 1University of
South Florida, Tampa, FL; 2Lions Eye Institute for
Transplant & Research, Tampa, FL
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
172
Monday – Posters – 2314 – 2335
2314 — B0258 The Accuracy of the 30 Degree
Test in Detecting Increased Intracranial Pressure
When Compared to CSF Opening Pressure on
Lumbar Puncture. Sungwon Rachel Kyung1, P.
Wall2, B. C. Hayden2, P. J. Rychwalski2. 1School
of Medicine, Case Western Reserve University,
Cleveland, OH; 2Ophthalmology, Cleveland Clinic
Cole Eye Institute, Cleveland, OH
2315 — B0259 Telepresence with multimedia
solutions during ophthalmology residency.
Thomas Kandl, L. Y. Huang, B. Szirth, A. S. Khouri.
Ophthalmology, UMDNJ-New Jersey Medical
School, Newark, NJ *CR
2316 — B0260 Orbital Volume as a Predictor
for Degree of Enophthalmos in Blowout
Fractures. Thao Phuong Le1, K. Howe1, L. M.
Mitsumori3, A. Jian-Amadi2, E. Sharifi2. 1University
of Washington, Seattle, WA; 2Ophthalmology,
University of Washington, Seattle, WA; 3Radiology,
University of Washington, Seattle, WA
2318 — B0262 Spatially programmable LEDbased illumination in the fundus camera. Dietmar
Link, S. Klee, J. Haueisen. Institute of Biomedical
Engineering and Informatics, Ilmenau University of
Technology, Ilmenau, Germany
2319 — B0263 Can Meaningful
Pharmacological Dilation of Pupils Occur After
Death? Jeffrey R. Golen1, T. Saunders1, N. Sprehe2,
P. Gore2, S. S. Malavade1, P. R. Pavan1, C. E.
Margo1. 1Department of Ophthalmology, University
of South Florida, Tampa, FL; 2Lions Eye Institute
for Transplant & Research, Tampa, FL
2320 — B0264 In situ monitoring cytochrome
c in dying RGC-5 cells by Raman microscopy.
Takeshi Morimoto1, H. Kanda1, L. Chiu2, K.
Fujita2, S. Kawata2, M. Nakamura3, K. Nishida4,
T. Fujikado1. 1Applied Visual Science, Osaka
Univ Graduate Sch of Med, Suita, Japan; 2Applied
Physics, Osaka Univ Graduate Sch of Eng, Suita,
Japan; 3Ophthalmology, Kobe Univ Graduate Sch
of Med, kobe, Japan; 4Ophthalmology, Osaka Univ
Graduate Sch of Med, Suita, Japan *CR
2321 — B0265 Portable Supine OCT for
Examination Under Anesthesia and Surgical
Guidance. Marco Ruggeri1, F. Cabot2, C. P. de
Freitas1, A. Canto2, M. C. Aguilar1, B. L. Lam2, S. H.
Yoo1, 2, J. A. Parel1. 1Ophthalmic Biophysics Center,
Bascom Palmer Eye Institute, University of Miami
Miller School of Medicine, Miami, FL; 2Anne Bates
Leach Eye Hospital, Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL *CR
2323 — B0267 Precision in positioning of
follow up examinations using optical coherence
tomography (OCT). Alexander Dietzel1, E.
Nagel1, 2. 1Biomedical Engineering, TU Ilmenau,
Institute of Biomedical Engineering and
Informatics, Ilmenau, Germany; 2Ophthalmology
practice, Rudolstadt, Germany
2324 — B0268 The Impact of Torsional Head
Movement on Disc to Fovea Angle Measurements
Used to Correct Optical Coherence Tomography
Scans. Adam Botwinick1, 2, A. S. Raza2, 3, D.
L. Wang2, D. C. Hood4. 1Medicine, Columbia
University, New York, NY; 2Psychology, Columbia
University, New York, NY; 3Neurobiology and
Behavior, Columbia University, New York, NY;
4
Psychology and Ophthalmology, Columbia
University, New York, NY *CR
2325 — B0269 Handheld Spectral Domain
Optical Coherence Tomography Imaging in
Undilated Preterm Infants in the NICU. Du
Tran-Viet1, R. S. Maldonado1, E. L. Yuan1, A. Y.
Tong3, C. A. Toth2. 1Ophthalmology, Duke Eye
Center - Duke University Medical Center, Durham,
NC; 2Biomedical Engineering, Duke University,
Durham, NC; 3Duke University School of Medicine,
Durham, NC *CR
2326 — B0270 Characteristics of Infantile
Nystagmus using Hand-Held Ultra-High
Resolution Spectral Domain Optical Coherence
Tomography in Infants and Small Children.
Helena Lee1, V. Sheth1, M. Bibi1, G. Maconachie1,
A. Patel1, F. A. Proudlock1, R. J. McLean1, M.
Michaelides2, 3, M. G. Thomas1, I. Gottlob1.
1
Ophthalmology Group, University of Leicester,
Leicester, United Kingdom; 2UCL Institute of
Ophthalmlogy, University College London, London,
United Kingdom; 3Moorfields Eye Hospital,
London, United Kingdom *CR
Exhibit Hall B0286-B0302
Monday, May 06, 2013 2:45 PM-4:30 PM
Visual Psychophysics / Physiological Optics
288 Refractive Errors, Myopia I
Moderator: Frances J. Rucker
2327 — B0286 Daily interruptions to hyperopic
defocus can reduce induced eye growth in
marmosets. Alexandra Benavente-Perez, A. Nour,
L. Yan, K. Roden, K. Abarr, D. Troilo. Biological
Sciences, SUNY College of Optometry, New York,
NY
2328 — B0287 Luminance and Color Changes
with Defocus Provide Differential Cues For
Emmetropization. Molly Fellows1, G. Kaur2,
A. Tang1, F. J. Rucker1. 1Biomedical Science &
Disease, New England College of Optometry,
Boston, MA; 2Southern California College of
Optometry, Fullerton, CA
2329 — B0288 Myelinated Retinal Nerve
Fibers associated Local Scleral Excavation
and Induced Axial Myopia: Investigation
using Spectral-domain Optical Coherence
Tomography. Baek-Lok Oh, J. Hwang, S. Woo.
Ophthalmology, Seoul National University College
of Medicine, Seoul National University Bundang
Hospital, Seognam, Republic of Korea
2330 — B0289 Comparing the Historical
and Contemporary Ocular Biometry of
Emmetropes. Jos J. Rozema1, 2, D. A. Atchison3, M.
B. Tassignon1, 2. 1Dept of Ophthalmology, Antwerp
University Hospital, Edegem, Belgium; 2Dept
of Medicine and Healthy Science, University of
Antwerp, Wilrijk, Belgium; 3School of Optometry
& Institute of Health and Biomedical Innovation,
Queensland University of Technology, Brisbane,
QLD, Australia
2331 — B0290 Effects of Eyeglass Correction
on Oral Reading Fluency in Elementary and
Middle School Children. Irene Campus1, M.
Crescioni1, T. K. Green1, J. D. Twelker1, 2, J. M.
Miller1, 2, E. M. Harvey1, 2. 1Ophthalmology and
Vision Science, University of Arizona, Tucson, AZ;
2
College of Public Health, University of Arizona,
Tucson, AZ
2332 — B0291 Peripheral photoreceptor
activity during accommodation and
emmetropization. Brian P. Schmidt1, M. Neitz2,
J. Neitz2. 1Graduate Program in Neurobiology and
Behavior, University of Washington, Seattle, WA;
2
Ophthalmology, University of Washington, Seattle,
WA *CR
2333 — B0292 Relation between refractive
astigmatism and change in spherical equivalent
with age in a sample of Native American children
age 3 to 18 years of age. Erin M. Harvey1, 2, J. D.
Twelker1, 2, J. M. Miller1, 2. 1Ophthalmology and
Vision Science, University of Arizona, Tucson, AZ;
2
College of Public Health, University of Arizona,
Tucson, AZ
2334 — B0293 Change in coma and spherical
aberration with accommodation in Native
American children of a tribe having elevated
levels of Corneal Astigmatism. Joseph M.
Miller1, 2, E. M. Harvey1, J. Schwiegerling2, 1.
1
Ophthal & Vision Science, University of Arizona,
Tucson, AZ; 2College of Optical Sciences,
University of Arizona, Tucson, AZ *CR
2335 — B0294 Monochromatic Aberrations,
Vision and Refractive Error in Healthy Young
Adults. David A. Mackey1, S. Yazar1, A. W. Hewitt1,
H. Forward1, C. M. McKnight1, A. X. Tan1, J. A.
Mountain2. 1Centre for Ophthalmology and Visual
Science, University of Western Australia, Lions Eye
Institute, Perth, WA, Australia; 2Centre for Child
Health Research, University of Western Australia,
Telethon Institute for Child Health Research, Perth,
WA, Australia
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
173
Monday Posters
2:45 pm – 4:30 pm
2317 — B0261 The impact on staff efficiency of
implementing a DICOM-compatible workflow
in an academic ophthalmology practice. Ravi
Pandit1, 3, M. V. Boland1, 2. 1Glaucoma Center of
Excellence, Wilmer Eye Institute, Johns Hopkins
University School of Medicine, Baltimore, MD;
2
Health Sciences Informatics, Johns Hopkins
University School of Medicine, Baltimore, MD;
3
Johns Hopkins Bloomberg School of Public Health,
Baltimore, MD
2322 — B0266 Comparison of retinal
measurements by spectral-domain optical
coherence tomography systems using a model
eye. Adam M. Dubis, F. A. Folgar, E. L. Yuan, S.
Farsiu, C. A. Toth. Ophthalmology/Eye Institute,
Duke University Eye Center, Durham, NC *CR
2336 – 2356 – Monday – Posters
2336 — B0295 Refractive Astigmatism and
the components of Astigmatism in preschool
children of China. Jia Huang, X. Zhou, X. Qu.
Ophthalmology, Eye Ear Nose and Throat Hospital
of Fudan University, Shanghai, China
2337 — B0296 Refractive and Corneal
Astigmatism in Autistic Spectrum Disorder.
Julie-Anne Little1, P. M. Anketell1, S. M. Gallagher2,
K. J. Saunders1. 1Biomedical Sciences, University
of Ulster, Coleraine, United Kingdom; 2School of
Psychology, University of Ulster, Coleraine, United
Kingdom
Monday Posters
2:45 pm – 4:30 pm
2338 — B0297 Unmet Need for Corrective
Eyeglasses: Follow-up Results from a Los
Angeles County Hospital Survey. Lloyd
M. Cuzzo1, 2, J. L. Berry1, 2, P. A. Quiros1, 2.
1
Ophthalmology, Doheny Eye Institute, Los
Angeles, CA; 2Keck School of Medicine, University
of Southern California, Los Angeles, CA
2339 — B0298 Epidemiological profile of
ophthalmological care in the Public Service in
Brazil. Marisa N. Figueiredo1, L. S. Stival1, M. L.
Machado1, J. J. Nassaralla2. 1Cornea and Refractive
Surgery, Instituto de Olhos de Goiânia, Goiania,
Brazil; 2Retina and Vitreous, IOG, Goiania, Brazil
f
2340 — B0299 Comparison of a Novel Cell
Phone-Based Refraction Technique (Netra-G)
with Subjective Refraction. Hilary Gaiser1, B.
Moore1, V. Pamplona2, N. Solaka1, D. Schafran1, D.
Merrill2, N. Sharpe2, J. R. Geringer2, R. Raskar2.
1
New England College of Optometry, Boston, MA;
2
EyeNetra Inc, Somerville, MA *CR
2341 — B0300 Comparison of Cycloplegic
Handheld Autorefraction with Conventional
Cycloplegic Retinoscopy in a Pediatric
Population. Smitha Inaganti1, N. Krishan-Dave2.
1
Ophthalmology, New York Medical College, New
York, NY; 2Ophthalmology, Metropolitan Hospital,
New York, NY
2342 — B0301 Evaluating Calibrated
Retinoscopy. Clinton N. Sims. Self Employed, Self
employed, Fort Myers, FL *CR
2343 — B0302 Ocular Refractive State
In Fighting Bulls. Juan I Seva1, M. Sanes1, F.
Martinez-Gomariz1, M. Lo Sapio2, J. M. Bueno2.
1
Facultad de Veterinaria, Universidad de Murcia,
Murcia, Spain; 2Laboratorio de Optica, Universidad
de Murcia, Murcia, Spain
Exhibit Hall C0001-C0019
Monday, May 06, 2013 2:45 PM-4:30 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
289 Neuro-Ophthalmology:
Inflammation, Ischemia, and Trauma
Moderator: Steven A. Newman
2344 — C0001 Concussion Screening in High
School Football Using the King-Devick Test.
Vladimir Yevseyenkov, K. Kaupke, S. Lebsock,
M. Kaminsky. Vision Rehabilitation, Midwestern
University, Glendale, AZ
2345 — C0002 The King-Devick (K-D) test
of rapid eye movements: a bedside correlate of
disability and quality of life in multiple sclerosis.
Elana S. Rosenberg1, S. Moster2, R. E. Sakai2, J.
A. Wilson2, G. Cutter3, S. L. Galetta4, 1, L. Balcer4,
1 1
. Ophthalmology, New York University School of
Medicine, New York, NY; 2Neurology, University
of Pennsylvania, Philadelphia, PA; 3University of
Alabama, Birmingham, AL; 4Neurology, New York
University School of Medicine, New York, NY *CR
2346 — C0003 Pattern-reversal visual evoked
potential, visual field and nerve fiber layer
thickness in neuromyelitis optica. Katharina
Stecher1, D. G. Brum2, V. M. Castro1, J. S. Paula1,
A. A. Barreira2, A. Messias1. 1Ophthalmology,
University of Sao Paulo, Ribeirao Preto, Brazil;
2
Neuroscience, University of Sao Paulo, Ribeirao
Preto, Brazil
2347 — C0004 Association between retinal
impairment and disease severity in Multiple
Sclerosis. Santiago Ortiz-Perez1, 2, E. H. MartinezLapiscina3, 2, I. Gabilondo3, 2, E. Fraga-Pumar3, 2,
S. Llufriu3, A. Saiz3, 2, B. Sanchez-Dalmau3, 2, P.
Villoslada1, 2. 1Institut Clinic D’Oftalmologia,
Hospital Clinic, Barcelona, Spain; 2Neuroimmunology, Institut Clinic d’investigacions
Biomedicas August Pi i Sunyer (IDIBAPS),
Barcelona, Spain; 3Neurology, Hospital Clinic,
Barcelona, Spain *CR
2348 — C0005 Retinal Nerve Fiber Layer
Thickness As Prognostic Indicator For The
Conversion To Clinically Definite Multiple
Sclerosis In Clinically Isolated Syndrome With
Acute Retrobulbar Optic Neuritis. Barbara
Giambene1, M. Grammatico Di Tullio2, L.
Massacesi2, U. Menchini1. 1Clinica Oculistica,
Università di Firenze, Firenze, Italy; 2Neurologia 2,
Università di Firenze, Firenze, Italy
2349 — C0006 Perimetric results in patients
with Multiple Sclerosis without optic neuritis.
Katja Goebel1, C. Erb2. 1Ophthalmology, Schloss
Park Clinic, Berlin, Germany; 2Eye clinic,
Wittenbergplatz, Berlin, Germany
2351 — C0008 The Central Response of the
Multi-focal electroretinograms (mf-ERG) and
the Threshold of the Static Visual Field (VF) in
Patients with Optic Nerve Lesions. Ari Kamei1,
E. Nagasaka2. 1Ari Eye Clinic, Oshu-Mizusawa,
Japan; 2Mayo Corp., Inazawa, Japan
2352 — C0009 A Comparison of Transition
Zones from Relatively Healthy to Severely
Affected Retinal Nerve Fiber Layer in
Glaucoma and NAION Patients. Monica
Chen1, A. S. Raza2, E. Su3, J. G. Odel4, C. De
Moraes5, J. M. Liebmann5, 6, R. Ritch6, 7, D. C.
Hood8. 1Biochemistry, Columbia University,
New York, NY; 2Neurobiology and Behavior,
Columbia University, New York, NY; 3School of
Medicine, Columbia University, New York, NY;
4
Ophthalmology, Columbia University, New York,
NY; 5Ophthalmology, NYU School of Medicine,
New York, NY; 6Einhorn Clinical Research Center,
New York Eye & Ear Infirmary, New York, NY;
7
Ophthalmology, New York Medical College,
Valhalla, NY; 8Psychology and Ophthalmology,
Columbia University, New York, NY *CR
2353 — C0010 Arteritic and Non-arteritic
Anterior Ischemic Optic Neuropathy:
Relative Incidence in Saudi Arabia. Timothy J.
McCulley, L. Phan, T. M. Bosley, Z. M. alsadah.
Ophthalmology, Wilmer Eye Institute, Johns
Hopkins, Baltimore, MD
2354 — C0011 Biopsy-Proven Giant Cell
Arteritis in an Urban African American
Population: a Hematologic and Demographic
Profile. Matthew S. Katz1, B. Katz1, 2.
1
Ophthalmology, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY;
2
Neurology and Neurosurgery, Montefiore Medical
Center - Albert Einstein College of Medicine,
Bronx, NY
2355 — C0012 Traumatic Avulsion of the
Optic Nerve. David Shiple, S. A. Newman.
Ophthalmology, Univ of Virginia Hlth Sci,
Charlottesville, VA
2356 — C0013 Clinical and Laboratory
Findings and Visual Disorders in Patients with
Macroprolactinoma. Juliana F. Araujo1, 6, E. F.
Almeida Sobrinho2, 5, T. Oikawa4, A. M. Santos3,
T. S. Rodrigues Neto3, V. F. Simões3, P. A. Paixao2,
6
, L. A. Fernandes2, 6, L. B. Botelho Vergara2, 6.
1
Faculdade de Medicina, Centro Universitario
do Para, Belém, Brazil; 2Instituto de Ciencias da
Saude, Universidade Federal do Para, Belem,
Brazil; 3Centro de Ciencias Biologicas e da Saude,
Universidade Estadual do Pará, Belem, Brazil;
4
Universidade Federal do Para, Belem, Brazil;
5
Hospital Universitario Bettina Ferro de Souza,
Universidade Federal do Para, Belem, Brazil;
6
Nucleo de Medicina Tropical, Universidade
Federal do Para, Belem, Brazil
2350 — C0007 Clinical features of retinal
diseases masquerading as retrobulbar optic
neuritis. Libin Jiang. Eye Center, Beijing Tongren
Hospital, Beijing, China
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
174
Monday – Posters – 2357 – 2376
2357 — C0014 Evaluation of Inner Retinal
Layers in Eyes with Temporal Hemianopic
Visual Loss from Chiasmal Compression using
Optical Coherence Tomography. Mario L.
Monteiro1, K. Hokazono1, D. B. Fernandes1, A. S.
Raza2, D. L. Wang2, D. C. Hood2, 3. 1Ophthalmology,
University of Sao Paulo, Sao Paulo, Brazil;
2
Psychology, Columbia University, New York, NY;
3
Ophthalmology, Columbia University, New York,
NY *CR
2358 — C0015 Photosensitive Post -TBI
Patients Show a Disproportionate Discomfort
Index Compared to Brightness Sense Compared
to Normal Subjects and Migraineurs. Susan
C. Anderson1, J. M. Full1, P. Poolman1, 2, J. N.
Pienta2, A. F. Russo3, R. H. Kardon1, 2. 1Center
for the Prevention and Treatment of Visual
Loss, Iowa City VA Health Care System, Iowa
City, IA; 2Ophthalmology&Visual Sciences,
University of Iowa, Iowa City, IA; 3Molecular
Physiology&Biophysics, University of Iowa, Iowa
City, IA *CR
2360 — C0017 Prevalence of Structural
Abnormalities of the Retinal Nerve Fiber Layer
(RNFL) and Ganglion Cell Layer Complex
(GCLC) by OCT in Veterans with Traumatic
Brain Injury (TBI). Randy H. Kardon1, 2,
M. K. Garvin1, 4, J. Wang1, 4, K. Cockerham3,
S. C. Anderson1, 2, J. M. Full1, 2, S. Lemke3,
G. C. Cockerham3. 1Center of Excellence for
the Prevention and Treatment of Visual Loss,
Department of Veterans Affairs, Rehabilitation
Research and Development Division, Iowa City, IA;
2
Ophthalmology and Visual Sciences, University of
Iowa, Iowa City, IA; 3Ophthalmology, Department
of Veterans Affairs, Palo Alto, CA; 4Electrical and
Computer Engineering, University of Iowa, Iowa
City, IA *CR
2361 — C0018 Central Visual Rehabilitation
for Cortical Vision Loss using Targeted
Luminance Variance Overlaid on an Athletic
Training Video Game. Roma Patel, K. Khaderi.
Ophthalmology, UC Davis, Sacramento, CA *CR
2362 — C0019 Grating acuity deficit and
interocular acuity difference in children with
cerebral visual impairment. Nívea N. Cavascan,
P. Y. Sacai, S. R. Salomao, A. Berezovsky.
Universidade Federal de São Paulo, São Paulo,
Brazil
Monday, May 06, 2013 2:45 PM-4:30 PM
Retina
290 DME
Moderator: Quan Dong Nguyen
2363 — C0064 Effect of Focal Laser and
anti-VEGF Therapy on Choroidal Thickness
in Diabetic Macular Edema as measured by
Enhanced-Depth Imaging Optical Coherence
Tomography. Varsha Manjunath1, G. Yiu1, S. J.
Chiu2, S. Stinnett1, S. Farsiu2, T. H. Mahmoud1.
1
Ophthalmology, Duke University Eye Center,
Durham, NC; 2Biomedical Engineering, Duke
University, Durham, NC *CR
2364 — C0065 The role of the macular
intraretinal cysts in evolution of capillary drop
out in diabetic macular retinopathy. A new
mechanism. Bilal Haj Najeeb1, C. Simader1,
U. Schmidt-Erfurth2. 1Vienna reading center,
Department of Ophthalmology, University
of Vienna, Vienna, Austria; 2Department of
Ophthalmology, University of Vienna, Vienna,
Austria *CR
2365 — C0066 Microperimetry-Guided
Micropulsed Laser Photo Stimulation for
the Treatment of Diabetic Macular Edema.
Renato Peroni1, 2, J. A. Cardillo4, 3, A. J. Dare2, R.
Jorge3. 1Retina Department, Hospital de Olhos de
Araraquara, Araraquara, Brazil; 2Retina Department,
Centro Brasileiro de Especialidades Oftalmológicas,
Araraquara, Brazil; 3Retina Department,
Universidade de São Paulo, Ribeirão Preto, Brazil;
4
Retina Department, Universidade Federal de São
Paulo, São Paulo, Brazil
2366 — C0067 Bevacizumab suppresses retinal
blood flow to reduce macular thickness in diffuse
diabetic macular edema. Masahiko Shimura1, S.
Watarai1, K. Yasuda1, D. Muramatsu1, 2, H. Goto2,
T. Nakazawa3. 1Ophthalmology, Tokyo Medical
University Hachioji Medical Center, Hachioji,
Japan; 2Ophthalmology, Tokyo Medical University,
Tokyo, Japan; 3Ophthalmology, Tohoku University
Graduate School of Medicine, Sendai, Japan *CR
2367 — C0068 Cataract and Diabetic Macular
Edema: a Prospective Comparative Trial
Investigating Phacoemusification Associated with
Intravitreal Micronized Triamcinolone Acetonide
or Bevacizumab. Gianluca Besozzi, A. Ferrara, E.
Epifani, D. Intini, M. Apruzzese, A. R. Provenzano,
M. Vetrugno. Ophthalmology, GVM Care and
Research - Italy, Bari, Italy
2368 — C0069 Oxygenation of retinal
vessels before and after laser therapy in
sight threatening diabetic macular edema.
Rosina Zakri, C. Angwin, S. Walker, N. Patel.
Ophthalmology, East Kent NHS Trust, Canterbury,
United Kingdom *CR, f
2369 — C0070 Truck Drivers Suffer Significant
Economic Harm Due to Diabetic Macular
Edema. Sunil S. Patel1, C. Peters2, K. L. Garcia1,
A. Jaimes1, B. Miller3, S. M. Kymes2, A. Turpcu3.
1
Retina Research Institute of Texas, Abilene, TX;
2
Washington University School of Medicine, Saint
Louis, MO; 3Genentech, Inc, South San Francisco,
CA *CR
2370 — C0071 Spectral-Domain Optical
Coherence Tomography Parameters Associated
with Baseline Vision in Diabetic Cystoid Macular
Edema. Abdulrahman M. Alfaran1, A. Mousa1, N.
G. Ghazi2. 1Ophthalmology, King Saud University,
Riyadh, Saudi Arabia; 2Vitreoretina, KIing Khalid
EyeSpecialist Hospital, RIYADH, Saudi Arabia
2371 — C0072 Diabetic Macular Edema
Treatment with Bevacizumab vs. Ranibizumab:
A Microperimetry Study. Antonio Brunno
Nepomuceno1, F. P. Almeida1, A. Messias1, E.
Takaki1, J. A. Ribeiro1, J. A. Cardillo2, I. U. Scott3,
R. Jorge1. 1Ophthalmology, School of Medicine of
Ribeirao Preto, University of São Paulo, Ribeirão
Preto, Brazil; 2Ophthalmology, Hospital de Olhos
de Araraquara, Araraquara, Brazil; 3Ophthalmology,
Ophthalmology & Public Health Sciences, Penn
State College of Medicine, Hershey,PA, PA f
2372 — C0073 Autoregulation of retinal vessel
diameter in diabetic macular edema is not
altered by intravitreal ranibizumab. Anastasia
P. Siegel, M. Haustein, N. Terai, L. E. Pillunat,
R. P. Stodtmeister, E. Spoerl. Ophthalmology, TU
Dresden, Dresden, Germany *CR
2373 — C0074 Baseline predictors of
3-year responses to ranibizumab and laser
photocoagulation therapy in patients with visual
impairment due to diabetic macular edema
(DME): the RESTORE study. Paul Mitchell,
V. Chong. Ophthalmology, University of Sydney,
Sydney, NSW, Australia *CR, f
2374 — C0075 Effect of combined treatment
of diabetic macular edema on macular ischemia.
Alexandros Deligiannidis1, J. Lorenzo Carrero2,
I. Perez Flores2, T. Paraskevopoulos3, P. Bolivar
Montesa1. 1CHUVI Vigo, Vigo, Spain; 2POVISA
Hospital, VIGO, Spain; 3“G. Gennimatas” General
Hospital of Athens, Athens, Greece
2375 — C0076 Reduced Energy Macular Laser
Phototherapy for the Treatment of Diabetic
Macular Edema. Alessandro J. Dare1, 2, J. A.
Cardillo3, 4, R. Jorge4, R. Belfort3, M. E. Farah3.
1
Ophthalmology, CBEO, Ribeirao Preto, Brazil;
2
Retina, Consultores de Retina e Vítreo, Ribeirão
Preto, Brazil; 3Ophthalmology, Federal University
of São Paulo, São Paulo, Brazil; 4Ophthalmology,
University of São Paulo - USP, Ribeirão Preto,
Brazil *CR
2376 — C0077 Relevance of inner versus outer
retinal thickness in diabetic macular edema in
the RELATION study. Tina Ristau1, J. Voegeler3,
G. E. Lang2, S. Liakopoulos1. 1Cologne Image
Reading Center, Department of Ophthalmology,
University of Cologne, Cologne, Germany;
2
Department of Ophthalmology, University of
Ulm, Ulm, Germany; 3Novartis Pharma GmbH,
Nuernberg, Germany *CR, f
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
175
Monday Posters
2:45 pm – 4:30 pm
2359 — C0016 Effect of Retinal Defocus on
Simple Eye-Foot Reaction Time in Traumatic
Brain Injury. Jennifer Gould, K. J. Ciuffreda, N.
K. Yadav, P. Thiagarajan. SUNY State College of
Optometry, New York, NY
Exhibit Hall C0064-C0118
2377 – 2402 – Monday – Posters
2377 — C0078 Photocoagulation for peripheral
nonperfusion-areas to prevent the recurrence of
diabetic macular edema after single intravitreal
injection of bevacizumab. Yoshihiro Takamura, T.
Tomomatsu, T. Matsumura, Y. Takihara, M. Inatani.
Ophthalmology, University of Fukui, Eiheiji
Yoshida, Japan f
2378 — C0079 Outcomes of Focal Laser
Photocoagulation for Diabetic Macular Edema
(DME) at Los Angeles County (LAC+USC)
Medical Center. Grace M. Richter, S. Patel, M.
Nittala, D. Bach, S. R. Sadda. Ophthalmology,
LAC+USC / Doheny, Los Angeles, CA *CR
Monday Posters
2:45 pm – 4:30 pm
2379 — C0080 Navigated Laser
Photocoagulation to Reduce Frequency of
Bevacizumab Injections (ivB) for Diabetic
Macular Edema: 1-Year Results. Giulio
Barteselli, S. Lee, I. Kozak, J. Chhablani, S. ElEmam, W. Freeman. Ophthal-Jacobs Retina Ctr,
Univ of California San Diego, La Jolla, CA *CR
2380 — C0081 Morphologic and functional
effects of Diode(810nm) and Yellow(577nm)
Subthreshold Micropulse Laser in CenterInvolving Diabetic Macular Edema. Stela
Vujosevic1, F. Martini1, E. Convento1, E. Longhin2,
E. Pilotto1, E. Midena1, 2. 1Department of
Ophthalmology, University of Padova, Padova,
Italy; 2Fondazione GB Bietti-IRCCS, Roma, Italy
2381 — C0082 Subthreshold Micropulse Diode
Laser Photocoagulation As Monotherapy For
Mild to Moderate Diabetic Macular Edema.
Rohit Adyanthaya, G. Zavala, V. H. Gonzalez.
Valley Retina Institute, McAllen, TX *CR
2382 — C0083 Tissue sparing micropulse laser
for the treatment of diabetic macular oedema.
Shanu Subbiah1, 2, M. Donaldson1, 2, M. Pradhan1.
1
Ophthalmology, University of Auckland, Auckland,
New Zealand; 2Ophthalmology, Auckland District
Health Board, Auckland, New Zealand
2383 — C0084 Efficacy of dexamethasone
intravitreal implant in diabetic macular edema.
Sophie Bonnin, B. M. Dupas, J. Perol, A. Erginay,
R. Tadayoni, P. Massin. Ophthalmology, Hôpital
Lariboisière, Université Paris Diderot - Sorbonne
Paris Cité, APHP, Paris, France *CR
2384 — C0085 Dexamethasone Intravitreal
Implant at the Time of Cataract Surgery in
Patients with Diabetic Macular Edema. Elena
Gusson1, G. Panozzo2, S. Casati1. 1Ophthalmology,
Verona University of Medicine, Verona, Italy;
2
Ophthalmology, Bussolengo Public Hospital,
Verona, Italy
2385 — C0086 Dexamethasone Intravitreal
Implant for Diabetic Macular Edema. Giacomo
Panozzo1, E. Gusson2, S. Casati2. 1Ophthalmology,
Bussolengo Public Hospital, Verona, Italy;
2
Ophthalmology, Verona University of Medicine,
Verona, Italy
2386 — C0087 Intravitreal Dexamethasone
Implant in Patients with Refractory Diabetic
Macular Edema. Pietro Frascio, F. Allavena, M.
Nicolò, S. Telani, C. E. Traverso. Clinica Oculistica,
Genova, Italy
2387 — C0088 Multicenter OZurdex
Assessment foR diabeTic macular edema:
MOZART study. Silvia Soare1, C. Hajjar2,
E. Parrat3, P. Merite4, S. Pommier5, F. Meyer4,
O. Prost-Magnin6, F. Matonti8, S. Guigou7.
1
Ophtalmology, Centre Hospitalier Henri Duffaut,
Avignon, France; 2Ophtalmology, P 1,5 Collective,
Basse-Terre, France; 3Ophtalmology, P 1,5
Collective, Baie-Mehault, France; 4Ophtalmology,
P 1,5 Collective, Aix en Provence, France;
5
Ophtalmology, P 1,5 Collective, Isle sur Sorgue,
France; 6Ophtalmology, P 1,5 Collective, Dijon,
France; 7Ophtalmology, P 1,5 Collective, Avignon,
France; 8Ophtalmology, P 1,5 Collective, Marseille,
France *CR
2388 — C0089 Real-life use of ranibizumab
in the treatment of diabetic macular edema:
results on visual acuity at month 6 in a French
Phase IV study (LUDIC study). Pascale Massin1,
L. Kodjikian2, M. Lelez3, A. Erginay1, S. Quéré4, V.
Schneider4. 1Ophthalmology, Hopital Lariboisiere,
Paris, France; 2Ophthalmology, Hôpital de la Croix
Rousse, Lyon, France; 3Ophthalmology, Hôpital
Bretonneaux, Tour, France; 4Research Deparment,
Novartis Pharma, Reuil Malamison, France *CR, f
2389 — C0090 Beneficial Effects of Intravitreal
Fasudil in Diabetic Macular Edema. Ali HafeziMoghadam1, R. Nourinia2, S. Zandi1, S. Nakao1, H.
Ahmadieh2. 1Radiology, Harvard Medical School,
Boston, MA; 2Ophthalmology, Labbafinejad
Medical Center, Tehran, Islamic Republic of Iran
2390 — C0091 The LUCIDATE study: a
randomized clinical trial to evaluate the longterm functional and anatomical effects of
repeated ranibizumab therapy compared with
laser in diabetic macular edema. Oliver Comyn,
T. Peto, C. Bunce, M. M. Neveu, G. E. Holder, P. J.
Patel, C. A. Egan, J. W. Bainbridge, P. G. Hykin.
NIHR Biomedical Research Centre at Moorfields
Eye Hospital and University College London
Institute of Ophthalmology, London, United
Kingdom *CR, f
2391 — C0092 Bevacizumab and Ranibizumab
in the treatment of diabetic macular oedema:
Can results from clinical trials be reproduced
in the National Health Service? Nicholas
Brennan1, 2, M. P. Treacy3, 2, C. Ramsden1, 2, N. Lee1.
1
Ophthalmology, Hillingdon Hospital, London,
United Kingdom; 2Ophthalmology, Institute of
ophthalmology, moorfields eye hospital, London,
United Kingdom; 3Ophthalmology, Royal Victoria
Eye and Ear Hospital, Adelaide Road, Dublin,
Ireland *CR
2392 — C0093 Viaual Outcomes Following
Bevacizumab Treatment in Diabetic Macular
Edema. Jluwi Almasaud1, A. M. Alfaran2, A.
Mousa2, N. G. Ghazi1. 1king khaled eye special
hospital, Riyadh, Saudi Arabia; 2king saud
university, Riyadh, Saudi Arabia
2393 — C0094 The Formation and Effect
of Posterior Vitreous Detachment During the
Treatment of Diabetic Macular Edema with
Bevacizumab. Sundeep Kasi, J. M. Stewart.
Ophthalmology, University of California San
Francisco, San Francisco, CA
2394 — C0095 Effects of intravitreal
ranibizumab on retinal hard exudates in patients
from the RIDE & RISE diabetic macular edema
trials. Michael S. Ip1, A. Domalpally1, D. Chen2, J.
S. Ehrlich2. 1Ophthalmology, Univ of WisconsinMadison, Madison, WI; 2Genentech, Inc., South San
Francisco, CA *CR, f
2395 — C0096 Ranibizumab for the treatment
of diabetic macular edema in patients treated
with Bevacizumab. Gisela Velez. 1Ophthalmology,
Univ of Massachusetts Med School, Worcester,
MA; 2Central Massachusetts Retina and Uveitis
Center, Worcester, MA
2396 — C0097 Intravitreal injections of
ranibizumab (Lucentis) with deferred laser
grid laser photocoagulation for the treatment of
diabetic macular edema with visual impairment:
intermediate results of LLOMD study. CazetSupervielle Agathe, M. Boissonnot, N. Leveziel.
Ophthalmology, University Hospital of Poitiers,
Poitiers, France f
2397 — C0098 Pegaptanib in the treatment
of ischemic diabetic macular edema. Christine
A. Kiire, R. Morjaria, R. M. Purbrick, S. Charisis,
S. Habal, V. Chong. Ophthalmology, Oxford Eye
Hospital, Oxford, United Kingdom *CR, f
2398 — C0099 Comparison of Bevacizumab
and Ranibizumab on Central Sub-Foveal
Thickness and Visual Acuity in Diabetic
Macular Edema. Loren S. Jack1, 2, C. R. Blake2.
1
Ophthalmology, University of South Carolina/
Palmetto Health, Columbia, SC; 2Ophthalmology,
William Jennings Bryan Dorn Veterans
Administration Memorial Center, Columbia, SC
2399 — C0100 Impaired Vascular Endothelial
Function in Patients with Diabetic Macular
Edema. Kengo Takahashi, T. Nagaoka,
A. Ishibazawa, K. Sogawa, A. Yoshida.
Ophthalmotology, Asahikawa Medical University,
Asahikawa, Japan
2400 — C0101 Association between Diabetic
Macular Edema and Chronic Kidney Disease
in Patients with Type 2 Diabetes. Akihiro
Ishibazawa, T. Nagaoka, K. Takahashi, A.
Takahashi, H. Yokota, A. Yoshida. Ophthalmology,
Asahikawa Medical University, Asahikawa, Japan
2401 — C0102 Response of Hyperreflective
Foci in Diabetic Macular Edema to Laser.
Anne-Marie Firan, R. Mathew, S. Sivaprasad.
Ophthalmology, King’s College Hospital, London,
United Kingdom *CR
2402 — C0103 External Limiting Membrane
and Inner Segment/Outer Segment Status at
pre- and post-pars plana vitrectomy in DME.
Noriko Miyamoto1, 2, M. Kuroda1, 2, S. Ito1, 2, M.
Shimozono1, 2, K. Ishida1, 2, Y. Kurimoto1, 2. 1Dept of
Ophthalmology, Kobe City Medical Center General
Hospital, Kobe, Japan; 2Institute of Biomedical
Research and Innovation, Kobe, Japan *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
176
Monday – Posters – 2403 – 2422
2403 — C0104 Association between Near
Infrared Autofluorescence and Optical
Coherence Tomography in Diabetic Macular
Edema. Shin Yoshitake, T. Murakami, A. Uji, K.
Ogino, N. Unoki, T. Horii, M. Hata, S. Arichika,
K. Nishijima, N. Yoshimura. Department of
Ophthalmology and Visual Sciences, Kyoto
University Graduate School of Medicine, Kyoto,
Japan *CR
2404 — C0105 Association between perifoveal
hyperfluorescence and serous retinal detachment
in diabetic macular edema. Tomoaki Murakami1,
A. Uji1, K. Ogino1, N. Unoki1, T. Horii1, S.
Yoshitake1, M. Hata1, K. Nishijima2, N. Yoshimura1.
1
Ophthalmology & Visual Sciences, Kyoto Univ
Grad Sch of Med, Kyoto, Japan; 2Nishijima Eye
Clinic, Kyoto, Japan *CR
2406 — C0107 Real-life use of ranibizumab
in the treatment of diabetic macular edema: the
population of a French Phase IV Study (LUDIC
study). Ali Erginay1, P. Massin1, L. Kodjikian2,
M. Le Lez3, S. Quéré4, V. Schneider4. 1Service d’
Ophtalmologie, Hôpital Lariboisière, Paris, France;
2
Service d’ Ophtalmologie, Hôpital de la CroixRousse, Lyon, France; 3Service d’ Ophtalmologie,
Hôpital Bretonneau, Tours, France; 4Research
Departement, Novartis Pharma, Rueil-Malmaison,
France *CR, f
2407 — C0108 No IOP-Elevation in patients
treated with Anti-VEGF ranibizumab for
diabetic macular edema. Peter P. Ciechanowski1,
M. Stahel1, F. Moser1, S. Lortz1, H. M. Fassnacht1,
N. T. Graf2, S. Estermann1, M. Becker1, S. Michels1.
1
Ophthalmology, Triemli Hospital Zurich, Zurich,
Switzerland; 2Graf Biostatistics, Winterthur,
Switzerland *CR
2408 — C0109 Association between OCT
findings and response to treatment in diabetic
macular edema. Young Joo Cho, D. Lee, M.
Kim, H. Koh. Ophthalmology, Institute of Vision
Research, Department of Ophthalmology, Yonsei
University College of Medicine, Seoul, Republic
of Korea
2409 — C0110 Efficacy of Ranibizumab in
the Treatment of Diabetic Macular Edema
Refractory to Bevacizumab. Harrison Sciulli, D.
G. Miller, J. Coney, M. A. Novak, J. P. Schartman,
L. J. Singerman, H. Zegarra. Retina Associates of
Cleveland, Cleveland, OH *CR
2411 — C0112 The Structural-Functional
Correlation in Patients with Diabetic Macular
Edema. Magdalena Sinczak, A. Sachdev, R.
Morjaria, V. Chong. Ophthalmology, Oxford
University Hospitals NHS Trust, Oxford, United
Kingdom *CR
2412 — C0113 Intravitreal Bevacizumab and
Ranibizumab for Diabetic Macular Edema; A
single center retrospective study. Daniel Choi,
J. I. Lim. Ophthalmology, University of Illinois at
Chicago, Chicago, IL *CR
2413 — C0114 Ranibizumab 0.5mg and 2.0mg
to Treat Diabetic Macular Edema in Patients
With Poor Response to Bevacizumab. Dante
J. Pieramici1, M. Nasir1, A. Castellarin1, R. F.
See1, S. Couvillion1, M. Bennett2, M. Rabena1, J.
Giust1, L. C. Wan1, R. L. Avery1. 1California Retina
Consultants, Santa Barbara, CA; 2Hawaii Retina
Institute, Honolulu, HI *CR, f
2414 — C0115 ILM peeling in non tractional
diabetic macular edema not responsive to
standard treatment. Paola A. Salvetti, L. Bonavia,
F. Bottoni, S. de Angelis, R. Secondi, M. G. Cereda,
G. Staurenghi. Dpt of Clinical Science, Eye Clinic
Sacco Hospital, Milano, Italy *CR
2415 — C0116 Dynamic Vessel Analysis May
Show an Improvement of Endothelial Function
by Intravitreal Ranibizumab in Diabetic
Macular Edema. Sylvana Ventzke, D. Sandner, E.
Spoerl, L. E. Pillunat, R. P. Stodtmeister. University
Eye Clinic, Dresden, Germany *CR
2416 — C0117 F/A and ICG guided, subthreshold, reduced fluence Focal Laser
Photocoagulation Treatment (SRFLPT) in
patients with Diabetic Clinically Significant
Macular Edema (CSME). Georgios Papastergiou,
F. El-Jabali, K. E. Waite, M. D. Bennett. Retina
Institute of Hawaii, Honolulu, HI f
2417 — C0118 The Impact of Systemic Factors
on Clinical Response to Vegf Inhibitors for
Diabetic Macular Edema. Simone Matsuda, T. J.
Tam, R. Singh, G. M. Smith, J. P. Ehlers. Cleveland
Clinic, Cleveland, OH *CR
Exhibit Hall C0119-C0150
Monday, May 06, 2013 2:45 PM-4:30 PM
Retina
291 DR: Clinical Research II
Moderators: James T. Handa and
Ingrid E. Zimmer-Galler
2418 — C0119 Diabetic Macular Ischemia
In Type 1 Diabetes. Zaman K. Durani1, 2, D. A.
Sim3, P. A. Keane3, M. Karampelas3, J. ZarranzVentura3, M. Fruttiger3, P. J. Patel3, A. Tufail3, C.
A. Egan3. 1St George’s Student Union, St Georges
Univ of London, London, United Kingdom;
2
Pharmacy, Moorfields Eye Hospital, London,
United Kingdom; 3NIHR Biomedical Research
Centre for Ophthalmology, Moorfields Eye Hospital
NHS Foundation Trust and UCL Institute of
Ophthalmology, Londno, United Kingdom *CR
2419 — C0120 Comparing the Microperimetric
to Structural Findings in Patients with Branch
Retinal Vein Occlusion and Diabetic Macular
Edema. Amun Sachdev, M. Sinczak, R. Morjaria,
V. Chong. Ophthalmology, Oxford University
Hospitals NHS Trust, Oxford, United Kingdom *CR
2420 — C0121 Quantitative Analysis of
Diabetic Macular Ischemia using Optical
Coherence Tomography. Pearse A. Keane1, 2, D. A.
Sim1, 2, S. S. Fung1, M. Karampelas2, S. R. Sadda4,
M. Fruttiger2, P. J. Patel1, 3, A. Tufail1, 3, C. A. Egan1,
3 1
. NIHR Biomedical Research Centre, Moorfields
Eye Hospital NHS Foundation Trust, London,
United Kingdom; 2Institute of Ophthalmology,
University College London, London, United
Kingdom; 3Medical Retina, Moorfields Eye
Hospital NHS Foundation Trust, London, United
Kingdom; 4Doheny Eye Institute, University of
Southern California, Los Angeles, CA *CR
2421 — C0122 Deviation from the Optimal
Branching Relationship of Retinal Vessels in
Diabetes Mellitus. Angela R. McAllister1, M. D.
Abramoff1, 3, X. Xu2. 1Ophthalmology and Visual
Sciences, University of Iowa, Iowa City, IA;
2
Electrical and Computer Engineering, University
of Iowa, Iowa City, IA; 3VA Hospital, Iowa City,
IA *CR
2422 — C0123 Retinal bifurcation angles in
severe non-proliferative diabetic retinopathy.
Shahin Golestani1, T. Banaee2, R. Daneshvar3, A.
Nabavi4. 1eye research center, khatam eye hospital,
Mashhad, Islamic Republic of Iran; 2vitroretinal
surgery, khatam eye hospital, Mashhad, Islamic
Republic of Iran; 3glaucoma center, khatam eye
hospital, Mashhad, Islamic Republic of Iran;
4
statistics center, emam reza hospital, Mashhad,
Islamic Republic of Iran *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
177
Monday Posters
2:45 pm – 4:30 pm
2405 — C0106 Equations to Convert Retinal
Thickness Measurements from Spectral
Domain OCT Machines to “Equivalent” Time
Domain OCT Measurements. Jared S. Nielsen.
Vitreoretinal Diseases and Surgery, Wolfe Eye
Clinic, West Des Moines, IA *CR
2410 — C0111 New software to assess retinal
non-perfusion on Optomap® Wide-Field Fundus
Fluorescein Angiography in Diabetic Macular
Oedema. Anna Sala-Puigdollers1, S. Caputo1, H.
Jaberansari2, J. Gray1, Y. D’Souza1, S. J. Charles1,
L. B. Young1, D. B. Henson1, 3, D. McLeod3, P. E.
Stanga1, 3. 1Vitreoretinal Unit, Manchester Royal
Eye Hospital, Manchester, United Kingdom;
2
School of Medicine, University of Manchester,
Manchester, United Kingdom; 3Manchester
Academic Health Science Centre and Centre for
Ophthalmology and Vision Research, Institute of
Human Development, University of Manchester,
Manchester, United Kingdom *CR
2423 – 2445 – Monday – Posters
Monday Posters
2:45 pm – 4:30 pm
2423 — C0124 Comparative Evaluation
of Non-Mydriatic Camera Images by NonOphthalmic and Ophthalmic Photographers as
part of a Primary Care Based Teleophthalmoogy
Diabetic Surveillance Program. Rajeev S.
Ramchandran1, V. Desmore1, T. A. Pannell1, W.
Fischer1, C. Sisson2. 1Ophthalmology, Flaum
Eye Institute, Rochester, NY; 2Biomedical
Photographic Communications, Rochester Institute
of Technology, Rochester, NY *CR
2424 — C0125 Endothelial Progenitor Cells
(EPCs) Detection In The Peripheral Blood Of
Young Diabetic Patients with Type 1 Diabetes
Mellitus (T1DM)- A Pilot Study. Chrysanthi
Tsika1, Z. Kapsala1, C. Pontikoglou2, V. Louvari3, D.
Mamoulakis3, H. A. Papadaki2, M. K. Tsilimbaris1.
1
Department of Neurology and Sensory Organs,
Eye CLinic of University Hospital of Heraklion,
University of Crete, Medical School, Heraklion,
Greece; 2Department of Internal Medicine,
Hematology Clinic of the Univesity Hospital of
Heraklion, University of Crete, Medical School,
Heraklion, Greece; 3Endocrinology & Diabetes,
Department of Pediatrics, University of Crete,
Medical School, Heraklion, Greece
2425 — C0126 Differences in Aqueous
Concentrations of Various Cytokines in
Macular Edema Due to Non-proliferative and
Proliferative Diabetic Retinopathy. Jing Feng, Y.
Jiang. Ophthalmology, Peking University People’s
Hospital, Beijing, China
2426 — C0127 Factors Affecting Successful
Completion of Panretinal Photocoagulation. Jan
A. Kylstra, H. E. Wright, R. Trivedi. Ophthalmology,
Medical Univ of South Carolina, Charleston, SC
*CR
2427 — C0128 Auto Anti-retinal Antibodies in
Diabetic Retinopathy. John R. Heckenlively, A. J.
Karoukis, M. I. Othman, T. W. Gardner. Ophthal &
Vis Sciences, Univ of Michigan-Kellogg Eye Ctr,
Ann Arbor, MI *CR
2428 — C0129 Subretinal layer thickness
ratio changes for early detection of diabetes.
Ryan Shelton1, J. N. Taibl2, 3, N. D. Shemonski1, S.
I. Sayegh2, S. A. Boppart1. 1Beckman Institute for
Advanced Science and Technology, University of
Illinois at Urbana-Champaign, Urbana, IL; 2Anterior
Segment & Vitreoretinal Surgury, The Eye Center/
The Retina Center, Champaign, IL; 3University of
Illinois at Urbana-Champaign, Urbana, IL *CR
2429 — C0130 Laser Photocoagulation For
Diabetic Retinopathy Using 532-nm Standard
Laser Versus Navigated Pattern Laser. Stephanie
Y. Lu1, 2, K. Y. Lin1. 1Ophthalmology, University of
California, Irvine, Irvine, CA; 2Ophthalmology,
Veterans Affairs Healthcare, Long Beach, CA
2430 — C0131 Diabetic self-management
and its association with diabetic retinopathy in
patients with type 2 diabetes. Ningpu Liu, N. Li, X.
Yang, Y. Deng, H. Gu, X. Ren, J. Xu, K. Ma. Beijing
Tongren Eye Center, Beijing Tongren Hospital,
Beijing, China
2431 — C0132 Association between Dibetic
Foot Ulcer and Diabetic Retinopathy. Duck
Jin Hwang1, 2, K. Lee1, 3, M. Park1, 3, S. Choi1, 4,
J. Park1, 4, K. Park1, 2, S. Woo1, 2. 1Seoul National
University College of Medicine, Seoul, Republic
of Korea; 2Ophthalmology, Seoul National
University Bundang Hospital, Seongnam, Republic
of Korea; 3Orthopedics, Seoul National University
Bundang Hospital, Seongnam, Republic of Korea;
4
Endoclinology, Seoul National University Bundang
Hospital, Seongnam, Republic of Korea
2432 — C0133 Retinal morphometry changes
observed in vivo measured with SD-OCT after
pan-retinal photocoagulation in patients with
proliferative diabetic retinopathy. Christoph
Mitsch, M. Bolz, B. Pemp, A. Reitner, C. D.
Scholda, U. Schmidt-Erfurth. Ophthalmology and
Optometrics, Medical University of Vienna, Vienna,
Austria *CR
2433 — C0134 Proliferative diabetic
retinopathy, maculopathy and choroidal
neovascularization: concurrent pathology.
Neda Minakaran1, G. Vafidis2, E. Mensah2.
1
Ophthalmology, Whipps Cross University Hospital,
London, United Kingdom; 2Ophthalmology, Central
Middlesex Hospital, London, United Kingdom
2434 — C0135 Metamizole as analgesic during
panretinal photocoagulation in proliferative
diabetic retinopathy. Rafael B. Araújo1, L. C.
Zacharias1, W. Y. Takahashi1, M. M. Leitão1, V.
P. Nascimento1, G. S. Melo2. 1Ophthalmology,
Universidade de São Paulo, São Paulo, Brazil;
2
Universidade Federal do Rio Grande do Norte,
Natal, Brazil *CR, f
2435 — C0136 The Relationship of Retinal
Vessel Caliber to Diabetic Macular Ischemia.
Gerald Liew1, 2, D. A. Sim1, 3, P. A. Keane1, 3, A.
G. Tan2, P. Mitchell2, J. Wang2, T. Y. Wong4, M.
Fruttiger3, A. Tufail1, 3, C. A. Egan1, 3. 1Moorfields
Eye Hospital NHS Foundation Trust, London,
United Kingdom; 2University of Sydney, Sydney,
NSW, Australia; 3UCL Institute of Ophthalmology,
London, United Kingdom; 4National University of
Singapore, Singapore, Singapore *CR
2436 — C0137 The influence of hemodialysis
treatment on retinal thickness and macular
edema in patients with diabetic retinopathy.
Lior Lipsky, O. Spierer, N. Azem, M. Shaked, M.
Neudorfer. Ophthalmology, Tel Aviv medical center,
Tel Aviv, Israel
2437 — C0138 Vision Risk Perception in
Older African Americans with Diabetes. Bianca
Collymore1, A. P. Murchison1, 2, R. J. Casten2, 1, L. A.
Hark1, 2, D. M. Weiss1, D. M. Johnson1, B. Rovner2, 1,
J. D. Henderer3, J. A. Haller1, 2. 1Wills Eye Insitute,
Philadelphia, PA; 2Thomas Jefferson University,
Philadelphia, PA; 3Ophthalmology, Temple
University Hospital, Philadelphia, PA *CR, f
2439 — C0140 Combination of intravitreal
injection of Pegaptanib plus progressive PRP
versus full PRP alone in patients with High
Risk Proliferative Diabetic Retinopathy. Sérgio
Leal1, 2, J. Figueira1, 2, L. Ribeiro1, M. Cachulo1, 2,
R. Silva1, 2, S. Nunes1, A. M. Pedroso1, M. Costa1,
J. G. Cunha-Vaz1. 1AIBILI - Association for
Innovation and Biomedical Research on Light and
Image, Coimbra, Portugal; 2CRIO / CHUC - Centro
de Responsabilidade Integrado de Oftalmologia,
Centro Hospitalar e Universitário de Coimbra,
Coimbra, Portugal *CR, f
2440 — C0141 Evaluation of systemic safety
by intravitreal injections of vascular endothelial
growth factor inhibitors for diabetic macular
edema: systematic review of literature and metaanalysis. Yasuko Yanagida, T. Yamaguchi, T. Ueta.
University of Tokyo, Tokyo, Japan
2441 — C0142 Morphological and functional
outcomes of different pattern of diabetic macular
oedema treated with 23gauge vitrectomy.
Giancarlo Sborgia1, L. Micelli Ferrari2, M.
Lorusso1, S. Ciani1, 2, M. Leozappa1, T. Micelli
Ferrari1. 1Medical Retina, Miulli, Acquaviva delle
Fonti, Italy; 2Azienda Ospedaliera Policlinico
Consorziale, Bari, Italy
2442 — C0143 Change of retinochoroidal
thickness after pars plana vitrectomy with
endophotocoagulation for proliferative diabetic
retinopathy. Kentaro Yamamoto, T. Iwase, H.
Ushida, H. Terasaki. Ophthalmology, Nagoya
University Hospital, Nagoya, Japan
2443 — C0144 Comparison of Outcomes
in the Use of Intravitreal Bevacizumab Vs.
Triamcinolone for Patients with Diabetic
Macular Edema at the Time of Cataract Surgery
(The DiMECAT Trial). Sukhpal S. Sandhu1, 2,
M. Constantinou1, 2, J. L. Morrison1, 2, C. J.
D’Sylva1, 2, R. Kawasaki1, 3, S. Wickramsinghe1, 2, S.
al-Qureshi1, 2, L. Lim1, 2. 1Centre for Eye Research
Australia, Melbourne, VIC, Australia; 2University of
Melbourne, Melbourne, VIC, Australia; 3Yamagata
University Faculty of Medicine, Yamagata, Japan
*CR, f
2444 — C0145 Identifying progression of
retinal disease in eyes with NPDR in diabetes
type 2 using non-invasive procedures. Jose G.
Cunha-Vaz. 1AIBILI - Association for Innovation
and Biomedical Research on Light and Image,
Coimbra, Portugal; 2EVICR.net - European Vision
Institute Clinical Research Network, Coimbra,
Portugal *CR, f
2445 — C0146 Retinal Oximetry Demonstrates
Differences in Vessel Oxygen Saturation
by Severity of Diabetic Retinopathy. Alexa
M. Waters, J. Miller, J. Mwanza, S. Garg.
Ophthalmology, University of North Carolina,
Chapel Hill, NC
2438 — C0139 Comparing Opt-in Versus Optout Recruitment Strategies for Ophthalmology
Research. David M. Weiss1, A. P. Murchison1, 2,
L. A. Hark1, 2, B. Collymore1, R. J. Casten2, 1,
R. Brawer2, J. D. Plumb2, B. Rovner2, 1, J. D.
Henderer3, J. A. Haller1, 2. 1Wills Eye Institute,
Philadelphia, PA; 2Thomas Jefferson University,
Philadelphia, PA; 3Ophthalmology, Temple
University Hopital, Philadelphia, PA *CR, f
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
178
Monday – Posters – 2446 – 2469
2446 — C0147 Plasma and vitreous fluid
levels of Dickkopf-1 in patients with diabetic
retinopathy. Fangfang Qiu1, J. He1, 4, Y. Zhou1,
Z. Liu1, J. Ma2, Z. Liu1, 3. 1Eye Institute, Xiamen
University, Xiamen, China; 2Department of
Physiology, The University of Oklahoma Health
Sciences Center, Oklahoma, OK; 3Xiamen Eye
Center Affiliated to Xiamen University, Xiamen,
China; 4ye Institute, Li Ka Shing Faculty of
Medicine, University of Hong Kong, Hong Kong,
China *CR
2448 — C0149 Influence of Baseline HbA1c on
Electroretinographic Changes During Long-term
Insulin Pump Therapy. Oliver Niels Klefter, M.
Larsen. Department of Ophthalmology, Glostrup
University Hospital, Glostrup, Denmark f
2449 — C0150 Effect of Metformin on the
Development of Diabetic Retinopathy. Christina
L. Ryu, M. Munie, S. Noorulla, P. A. Edwards,
X. Qiao, H. Gao. Ophthalmology, Henry Ford
Hospital, Detroit, MI
Exhibit Hall D0055-D0083
Monday, May 06, 2013 2:45 PM-4:30 PM
Biochemistry/Molecular Biology
292 Phototransduction, Retinal
Development, Molecular Biology
and Biochemistry
Moderator: Alecia K. Gross
2450 — D0055 Retinal Horizontal cell
numbers are modulated by neuron specific
methyl transferase, PRMT8. Ratnesh Singh1, Y.
Mori2, S. Miyata2, M. Tohyama2, V. Ramamurthy1.
1
Ophthalmology, West Virginia University,
Morgantown, WV; 2Anatomy and Neuroscience,
Osaka University, Osaka, Japan
2451 — D0056 Characterization of
recombinant intra-melanosomal domain of
human tyrosinase. Monika B. Dolinska1, P. S.
Backlund2, B. P. Brooks1, Y. V. Sergeev1. 1OGVFB,
National Eye Institute, Bethesda, MD; 2NICHD/
NIH, Bethesda, MD
2453 — D0058 Characterization and PostTranslational Modifications of Proline-Rich
Protein 4 (PRR4) in Basal and Reflex Tear
Proteome of Human. Natarajan Perumal, S.
Funke, N. Pfeiffer, F. H. Grus. Experimental
Ophthalmology, University Medical Center Mainz,
Mainz, Germany *CR
2454 — D0059 Steric Volume Exclusion Leads
to Size-dependent Protein Distribution in Mouse
Ciliary Photoreceptors. Mehdi Najafi1, 2, P. D.
Calvert1, 2. 1Department of Ophthalmology, SUNY
Upstate Medical University, Syracuse, NY; 2SUNY
Eye Institute, Syracuse, NY
2455 — D0060 Refined estimates of rhodopsin
deactivation kinetics from mouse rods lacking
rhodopsin phosphorylation or Arr1 binding.
Owen P. Gross1, 2, E. N. Pugh2, 4, M. E. Burns2,
3 1
. Vollum Institute, Oregon Health & Science
University, Portland, OR; 2Center for Neuroscience,
UC Davis, Davis, CA; 3Ophthalmology & Vision
Science, UC Davis, Davis, CA; 4Cell Biology and
Human Anatomy, UC Davis, Davis, CA
2456 — D0061 Robust self-association of
arrestin-1 is a neuroprotective mechanism.
Eugenia V. Gurevich1, X. Song1, J. Seo1, F.
Baameur1, S. A. Vishnivetskiy1, Q. Chen1, M.
Kim2, J. Chen3, W. L. Hubbell2, V. V. Gurevich1.
1
Pharmacology, Vanderbilt University, Nashville,
TN; 2University of California Los Angeles, Los
Angeles, CA; 3University of Southern California,
Los Angeles, CA
2457 — D0062 Adaptive acceleration in
mouse rods is mediated by slow feedback via
guanylate cyclase activating proteins. Marie E.
Burns1, 2, O. P. Gross1, C. M. Krispel3, 4. 1Center for
Neuroscience, Univ of California-Davis, Davis,
CA; 2Cell Biology and Human Anatomy, Univ of
California-Davis, Davis, CA; 3Ophthalmology &
Vision Science, Univ of California-Davis, Davis,
CA; 4Wilmer Eye Institute, Johns Hopkins Hospital,
Baltimore, MD
2458 — D0063 Critical role of central 139 loop
in stability and binding selectivity of arrestin-1.
Sergey A. Vishnivetskiy, F. Baameur, K. R.
Findley, V. V. Gurevich. Pharmacology, Vanderbilt
University, Nashville, TN
2459 — D0064 Modulation of Mouse Rod
cGMP-Gated Channels by Grb14. Raju V.
Rajala1, M. L. Woodruff2, G. L. Fain2, 3. 1Ophthal/
Dean McGee Eye Inst, Univ of Oklahoma Hlth Sci
Ctr, Oklahoma City, OK; 2Integrative Biology and
Physiology, UCLA, Los Angeles, CA; 3Jules Stein
Eye Inst, UCLA, Los Angeles, CA
2460 — D0065 Independent manipulation
of binding selectivity and self-association
of arrestin-1. Vsevolod V. Gurevich1, S. A.
Vishnivetskiy1, Q. Chen1, M. C. Palazzo1, E. K.
Brooks2, C. Altenbach2, T. M. Iverson1, W. L.
Hubbell2. 1Pharmacology, Vanderbilt University,
Nashville, TN; 2JSEI, UCLA, Los Angeles, TN
2461 — D0066 A New Form of Photoreceptor
Light Adaptation: Enhanced Current Following
Sustained Illumination. Alex S. McKeown, T.
W. Kraft. Vision Sciences, Univ of Alabama at
Birmingham, Birmingham, AL
2462 — D0067 EM-structure and functional
properties of the rhodopsin-transducin complex.
Beata Jastrzebska, T. Orban, M. Golczak, A.
Engel, K. Palczewski. Pharmacology, Case Western
Reserve University, Cleveland, OH *CR
2463 — D0068 Mechanisms of Retinal Vascular
Alteration in Hyperhomocysteinemia. Amany
M. Tawfik1, 2, S. Markand1, 2, S. Magyerdi2, 3, M. A.
Al-Shabrawey2, 3, S. B. Smith1, 2. 1Cellular Biology &
Anatomy, Georgia Health Sciences Univ, Augusta,
GA; 2Vision Discovery Institute, GHSU, Augusta,
GA; 3Oral Biology/Anatomy, GHSU, Augusta, GA
2464 — D0069 A Prospective Study of InOffice Diagnostic Vitreous Sampling in Patients
with Vitreoretinal Pathology, 2007-2011. Bert M.
Glaser, S. M. Ecker, J. C. Hines, A. O. Igbre. Ocular
Proteomics, National Retina Institute, Towson, MD
*CR
2465 — D0070 Mouse Vitreoretinal Proteome.
Jessica M. Skeie1, 2, S. H. Tsang3, V. B. Mahajan1, 2.
1
Ophthalmology and Visual Sciences, University
of Iowa, Iowa City, IA; 2Omics Laboratory,
University of Iowa, Iowa City, IA; 3Bernard and
Shirlee Brown Glaucoma Laboratory, Department
of Ophthalmology, Columbia University, New York,
NY
2466 — D0071 The novelty of Toll like
receptor-4 ligand and RGC degeneration.
Yasunari Munemasa, K. Takada, K. Kojima, S.
Ueno, Y. Kitaoka. Ophthalmology, St Marianna
University, Kawasaki, Japan *CR
2467 — D0072 Retinal disruption in MTHFR
deficient mice. Shanu Markand1, 3, A. M. Tawfik1, 3,
S. Sonne2, P. M. Martin2, 3, S. B. Smith1, 3. 1Cellular
Biology Anatomy, Georgia Health Sciences
University, Augusta, GA; 2Biochemistry, Georgia
Health Sceinces University, Augusta, GA; 3Vision
Discovery Institute, Georgia Health Sciences
University, Augusta, GA
2468 — D0073 A conserved miRNA pathway
regulates competence in retinal progenitor cells.
Anna La Torre, S. A. Georgi, T. A. Reh. Biological
Structure, University of Washington, Seattle, WA
2469 — D0074 Optimizing Laser Capture
Microdissection to Study Spatiotemporal Gene
Expression in the Retinal Ganglion Cell Layer.
Steve Huynh, D. C. Otteson. University of Houston,
College of Optometry, Houston, TX
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
179
Monday Posters
2:45 pm – 4:30 pm
2447 — C0148 Evaluation of Choroidal
Thickness in High-Risk Proliferative Diabetic
Retinopathy Treated With Panretinal
Photocoagulation Associated or Not With
Intravitreal Bevacizumab Injections: A 3
Months, Randomized, Controlled and Masked
Clinical Trial. Rony C. Preti1, A. Mutti1, L. M.
Vazquez1, D. A. Ferraz1, L. C. Zacharias1, M.
K. Carra2, D. E. Pelayes3, M. L. Monteiro1, W.
Y. Takahashi1. 1Ophthalmology, University of
Sao Paulo, Sao Paulo, Brazil; 2Endocrinology,
University of Sao Paulo, Sao Paulo, Brazil;
3
Ophthalmology, Center for Applied Research and
High Complexity in Ophthalmology, Buenos Aires,
Argentina *CR, f
2452 — D0057 Interactions between Dopamine
Receptor D4 and Visual Arrestins. Janise D.
Deming1, 2, K. Lim1, 2, B. M. Brown1, 2, J. Pak1, 2, K.
Van Craenenbroeck3, C. M. Craft1, 2. 1Mary D. Allen
Lab for Vision Research, Doheny Eye Institute,
Los Angeles, CA; 2Ophthalmology & Cell &
Neurobiology, Keck School of Medicine of Univ.
Southern Calif., Los Angeles, CA; 3Physiology,
University of Gent, Gent, Belgium
2470 – 2492 – Monday – Posters
2470 — D0075 A Non-Radioactive Assay
for Measuring Retinal Base Excision Repair
Capability. Vincent T. Ciavatta1, 2, P. P. Cunha2, J.
H. Boatright2, S. M. Tang2. 1Rehabilitation R & D,
Center of Excellence, US Dept of Veterans Affairs,
Decatur, GA; 2Ophthalmology, Emory University
School of Medicine, Atlanta, GA
2471 — D0076 Evolutionarily Conserved
Minor Spliceosome is Required for
Differentiating Mouse Retinal Neurons. Rahul
N. Kanadia, A. M. Kilcollins. Physiology and
Neurobiology, University of Connecticut, Storrs, CT
Monday Posters
2:45 pm – 4:30 pm
2472 — D0077 Retinal pigment epithelial
cells evade apoptosis during TGF-β1-induced
epithelial-mesenchymal transition adopting
survivin. Jungeun Lee, J. Choi, C. Joo. Catholic
Institutes of Visual Science, College of Medicine,
Catholic University of Korea, Seoul, Republic of
Korea
2473 — D0078 Regulation of Set-β’s subcellular
localization and posttranslational modifications
affect axon growth and regeneration. Melina
I. Morkin1, E. F. Trakhtenberg1, 2, Y. Wang1, S.
Fernandez3, G. M. Mlacker4, J. L. Goldberg1, 2.
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2Neuroscience Program, University of
Miami, Miami, FL; 3University of Miami, Miami,
FL; 4Miller School of Medicine, University of
Miami, Miami, FL
2474 — D0079 Early Ischemia-reperfusion
Injury Induces Retinal Vascular Permeability
in a VEGF Receptor 2 Dependent Manner
Followed by Occludin Phosphorylation and
Ubiquitination. Arivalagan Muthusamy, C. Lin,
H. Lindner, S. Shanmugam, S. F. Abcouwer, D. A.
Antonetti. Ophthalmology & Vis Sciences, Univ of
Michigan Kellogg Eye Ctr, Ann Arbor, MI
2475 — D0080 Oligonucleotide-mediated
gene correction in human primary fibroblasts.
Magdalena M. Staniszewska, M. B. Consugar, M.
H. Farkas, E. A. Pierce. Ocular Genomics Institute,
Department of Ophthalmology, Massachusetts Eye
and Ear Infirmary, Harvard Medical School, Boston,
MA *CR
2476 — D0081 Compensation for the loss of
the alpha7 nAChR in the retina of the alpha7
nAChR knockout mouse. Marci L. Smith1, F.
Souza2, C. E. Strang2, B. J. Morley3, K. T. Keyser2.
1
Psychology, University of Alabama at Birmingham,
Birmingham, AL; 2Vision Science, University of
Alabama at Birmingham, Birmingham, AL; 3Boys
Town National Research Hospital, Omaha, NE
2477 — D0082 The role of extracellular
histones in retinal detachment. Hiroki Kawano1,
T. Ito2, I. Maruyama2, T. Sakamoto1. 1Opthalmology,
Kagoshima University Graduate School of Medical
and Dental School, Kagoshima, Japan; 2Systems
Biology in Thromboregulation, Kagoshima
University Graduate School of Medical and Dental
Sciences, Kagoshima, Japan
2478 — D0083 Prdm8 and Bhlhb4 in the retina
and CNS. Sasha Woods1, A. Stewart2, C. Jung3, S.
Ross4, 5, A. D. Dick1, C. Warburton6, R. R. McInnes3,
D. Atan1. 1Academic Unit of Ophthalmology,
University of Bristol, Bristol, United Kingdom;
2
School of Biosciences, Cardiff University,
Cardiff, United Kingdom; 3Molecular Genetics,
University of Toronto, Toronto, ON, Canada;
4
Department of Neurobiology, Harvard Medical
School, Boston, MA; 5Department of Neurobiology
and Anesthesiology, University of Pittsburgh,
Pittsburgh, PA; 6Physiology and Pharmacology,
University of Bristol, Bristol, United Kingdom *CR
Exhibit Hall D0084-D0097
Monday, May 06, 2013 2:45 PM-4:30 PM
Visual Neuroscience
293 Biology and Function of Rod and
Cone Photoreceptors
Moderator: Kwoon Y. Wong
2479 — D0084 Rod outer segments metabolism
and retinal degenerative diseases: new
perspectives. Isabella Panfoli1, D. Calzia1, S.
Candiani2, G. Garbarino2, L. Manni3, F. Caicci3, C.
Canale4, S. Ravera1, A. Diaspro4, C. E. Traverso5.
1
DIFAR, Università di Genova, Genova, Italy;
2
DISTAV, Università di Genova, Genova, Italy;
3
Dip.to di Biologia, Università di Padova, Padova,
Italy; 4Dip.to di Nanofisica, Istituto Italiano di
Tecnologia (IIT), Genova, Italy; 5DINOGMIClinica Oculistica, Università di Genova, Genova,
Italy
2480 — D0085 UNC119 Knockdown Results in
Visual Impairment in Zebrafish. Hadas StiebelKalish2, 1, N. Rainy3, Y. Gothilf3, Y. Nisgav5, T.
Livnat5, M. Bach4. 1Ophthalmology, Rabin Medical
Center, Petah Tikva, Israel; 2Sackler School of
Medicine, Tel Aviv University, Tel Aviv, Israel;
3
Department of Neurobiology, George S. Wise
Faculty of Life Sciences, Tel Aviv University,
Tel Aviv, Israel; 4Department of Ophthalmology,
University of Freiburg, Freiburg, Germany;
5
Laboratory of Eye Research, Felsenstein Medical
Research Center, Petah Tikva, Israel
2481 — D0086 Structural characterization
of mouse and human rhodopsin in native
membranes. Allison Whited, J. Detweiler, P. S.
Park. Case Western Reserve University, Cleveland,
OH
2482 — D0087 Analysis of the Expression
of the Rhodopsin Gene Rh1 in Retinas of
Nocturnal and Diurnal Dipsadidae Snakes
and Comparative Study of the Density of
Photoreceptors and GCL Cells. Einat Hauzman1,
D. M. Bonci2, M. Neitz3, J. Neitz3, D. F. Ventura1, 2.
1
Neuroscience and Behavior, University of
São Paulo, São Paulo, Brazil; 2Experimental
Psychology, University of São Paulo, São Paulo,
Brazil; 3Department of Ophtalmology, University of
Washington, Seattle, WA *CR
2483 — D0088 R9AP-overexpression in rods
increases rod-driven optomotor sensitivity
to high temporal frequencies at mesopic
illumination levels. Yumiko Umino, E. C. Solessio.
Ophthalmology, Center for Vision Research, SUNY
Eye Institute, SUNY Upstate Medical University,
Syracuse, NY
2484 — D0089 Measuring cone recovery
kinetics after bleaching. Sascha Klee, D. Link,
P. Bessler, J. Haueisen. Institute of Biomedical
Engineering and Informatics, Ilmenau University of
Technology, Ilmenau, Germany
2485 — D0090 Achromatopsia-associated
mutation in CNGA3 potentiates the
phosphoinositide sensitivity of cone
photoreceptor CNG channels by altering
intersubunit interactions. Gucan Dai, M. D.
Varnum. Program in Neuroscience, Washington
State University, Pullman, Pullman, WA
2486 — D0091 Studying GCAP-independent
Ca2+ Feedback in Mammalian Cones. Frans
Vinberg1, J. Chen2, V. J. Kefalov1. 1Ophthalmology
& Visual Sciences, Washington University School
of Medicine, Saint Louis, MO; 2University of
Southern California, Los Angeles, CA
2487 — D0092 Endocytosis at rod
photoreceptor synapses. Karlene M. Cork, W. B.
Thoreson. University of Nebraska Medical Center,
Omaha, NE
2488 — D0093 Mechanisms of Photoreceptor
Synaptic Ribbon Plasticity in the Hibernating
Ground Squirrel Retina. Fengyu Qiao1, S. Chen1,
D. Merriman2, W. Li1. 1NEI/NIH, Bethesda, MD;
2
Univ. of Wisconsin-Oshkosh, Oshkosh, WI
2489 — D0094 Synaptojanin1 is Involved
in Trafficking Synaptic Proteins in Cone
Photoreceptors. Ashley George, S. E. Brockerhoff.
Biochemistry, University of Washington, Seattle,
WA
2490 — D0095 Fast Glutamate Uptake by
EAAT2 Prevent Glutamate Depletion in Rod
Photoreceptors. Lauren A. Purpura1, H. Ripps2,
W. Shen1. 1College of Medicine, Florida Atlantic
University, Boca Raton, FL; 2Ophthalmology and
Visual Science, University of Illinois College of
Medicine, Chicago, IL
2491 — D0096 The endothelin receptor A
(ETA) would be involved in the intrarretinal
transmission of visual stimuli. Vicente Bermudez,
A. M. Suburo. Cell and Molecular Medicine,
Universidad Austral - FCB, Pilar, Argentina
2492 — D0097 Rod-Cone Coupling Studied
in Single Mouse Cones: Impact and Regulation.
Sabrina Asteriti1, 2, C. M. Gargini2, L. A. Cervetto2,
L. Cangiano1. 1Dept. of Translational Research,
University of Pisa, Pisa, Italy; 2Dept. of Pharmacy,
University of Pisa, Pisa, Italy
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
180
Monday – Posters – 2493 – 2512
Exhibit Hall D0098-D0106
Monday, May 06, 2013 2:45 PM-4:30 PM
Visual Neuroscience
294 Retinal Development
Moderator: Peter G. Fuerst
2493 — D0098 Examining the role of celsr3
in amacrine cell development in the zebrafish
retina. Alaron Lewis1, J. T. Mahoney2, N. Wilson1,
S. E. Brockerhoff1. 1Biochemistry, University of
Washington, Seattle, WA; 2Science and Technology,
University of Washington, Bothell, WA
2495 — D0100 Genetic Regulation of Type 3b
Cone Bipolar Cell Number. Irene E. Whitney1, 2,
P. W. Keeley1, 2, S. Borhanian1, 2, B. E. Reese3, 2.
1
Molecular, Cellular, and Developmental Biology,
University of California at Santa Barbara, Santa
Barbara, CA; 2Neuroscience Research Institute,
University of California at Santa Barbara, Santa
barbara, CA; 3Psychological & Brain Sciences,
University of California at Santa Barbara, Santa
barbara, CA
2496 — D0101 A Locus on Chromosome 11
Regulates Spacing of Cholinergic Amacrine Cells
in the Mouse Retina. Patrick W. Keeley1, 3, I. E.
Whitney1, 3, B. E. Reese2, 3. 1Molecular, Cellular, and
Developmental Biology, University of California,
Santa Barbara, CA; 2Psychological and Brain
Sciences, Unviersity of California, Santa Barbara,
CA; 3Neuroscience Research Institute, University of
California, Santa Barbara, CA
2497 — D0102 DSCAM is required for
functional retinal circuitry. Arash Ng1, E.
Zampaglione1, P. G. Fuerst3, 4, R. W. Burgess5, A.
M. Litke2, D. Feldheim1, A. Sher2. 1MCD Biology,
University of California, Santa Cruz, Santa Cruz,
CA; 2Sanra Cruz Institute of Particle Physics,
University of California, Santa Cruz, Santa
Cruz, CA; 3Biological Sciences, University of
Idaho, Moscow, ID; 4WWAMI Medical Program,
University of Washington, Seattle, WA; 5Jackson
Laboratory, Bar Harbor, ME
2498 — D0103 Dopamine D1 receptor regulates
the functional development of retina. Ning
Tian1, Q. He2, P. Wang1. 1Ophthalmology & Visual
Science, University of Utah, Salt Lake City, UT;
2
College of Pharmacy, The Ohio State University,
Columbus, OH
2500 — D0105 Development of the cone
photoreceptor-to-cone bipolar cell synapse
depends on visual activity. Felice Dunn1, A. W.
Azevedo2, R. O. Wong1. 1Biological Structure,
University of Washington, Seattle, WA;
2
Neurobiology, Harvard Medical School, Boston,
MA
2501 — D0106 Unconvential Myosin VI
motor protein is required for iris development
and outer retinal function. Ivy S. Samuels1, 2,
B. A. Bell2, G. M. Sturgill-Short1, 2, L. Shi3, N. S.
Peachey1, 2, P. M. Nishina3. 1Research Service, Louis
Stokes Cleveland VA Medical Center, Cleveland,
OH; 2Department of Ophthalmic Research, Cole
Eye Institute, Cleveland Clinic, Cleveland, OH;
3
The Jackson Laboratory, Bar Harbor, ME
Exhibit Hall D0107-D0117
Monday, May 06, 2013 2:45 PM-4:30 PM
Visual Neuroscience
295 Amacrine and Glial Cells
Moderator: William Grimes
2502 — D0107 Correlation of retinal blood
vessels with functional sublaminas of the inner
plexiform layer. Elena Ivanova, A. Toychiev, C.
Yee, B. T. Sagdullaev. Burke-Cornell Medical
Research Institute, White Plains, NY
2503 — D0108 Pure feedforward amacrine
cells. Robert E. Marc, F. R. Vazquez-Chona, J. V.
Hoang, C. L. Sigulinsky, C. B. Watt, B. W. Jones, J.
R. Anderson, J. Lauritzen. Ophthalmology-Sch of
Med, Univ of Utah/Moran Eye Center, Salt Lake
City, UT *CR
2504 — D0109 Viral transfer of the geneticallyencoded chloride indicator Clomeleon into
ChAT/Cre retinae to study chloride dynamics
in “starburst” amacrine cells. Tanja Grau1, S.
Michalakis2, 3, T. Euler1. 1Institute for Ophthalmic
Research, University of Tuebingen, Tuebingen,
Germany; 2Center for Integrated Protein Science
Munich, Ludwig-Maximilians-University Munich,
Munich, Germany; 3Department of Pharmacy Center for Drug Research, Ludwig-MaximiliansUniversity Munich, Munich, Germany
2506 — D0111 Direct In-Vivo Measurement of
Nitric Oxide in the Rat Retina. Micah J. Guthrie,
C. R. Osswald, J. J. Kang Mieler. Biomedical
Engineering, Illinois Institute of Technology,
Chicago, IL
2507 — D0112 Characterization of the
vesicular nucleotide transporter (VNUT)
in mammalian retina. Matthew Voas1, 2, N.
Muddasani2, Y. Moriyama3, S. Stella1, 2. 1Department
of Ophthalmology, UMKC School of Medicine,
Kansas City, MO; 2Basic Medical Sciences, UMKC
School of Medicine, Kansas City, MO; 3Membrane
Biochemistry, Okayama University Graduate
School of Medicine, Okayama, Japan
2508 — D0113 Dopamine Regulation of
Dye-Coupling in Fountain Amacrine Cells of
the Rabbit Retina. Christopher M. Whitaker, S.
C. Massey. Ophthalmology and Visual Science,
University of Texas, HSC at Houston, Houston, TX
2509 — D0114 Sparse network principles
of GABAergic amacrine cell heterocellular
coupling. Crystal L. Sigulinsky, J. Lauritzen, J. V.
Hoang, C. B. Watt, B. W. Jones, J. R. Anderson, S.
Mohammed, R. E. Marc. Ophthalmology-School of
Medicine, University of Utah/Moran Eye Center,
Salt Lake City, UT *CR
2510 — D0115 Secondary Cell Death of
Amacrine Cells Under Excitotoxic and Ischemic
Conditions is Mediated by Gap Junctions
Formed with Neighboring Ganglion Cells.
Stewart A. Bloomfield1, 2, T. Atlasz1, B. Volgyi1, A.
Akopian1, 2. 1Dept of Physiology & Neuroscience,
New York Univ Sch of Medicine, New York, NY;
2
Biological and Visual Sciences, SUNY College of
Optometry, New York, NY
2511 — D0116 Immunohistochemical
identification and characterization of a widefield amacrine cell type in marmoset retina. Felix
Weltzien1, 2, S. Di Marco3, D. A. Protti3, T. Daraio1,
P. R. Martin1, 2, U. Grunert1, 2. 1Department of
Ophthalmology and Save Sight Institute, University
of Sydney, Sydney, NSW, Australia; 2Australian
Research Council Centre of Excellence in Vision
Science, University of Sydney, Sydney, NSW,
Australia; 3School of Medical Sciences, University
of Sydney, Sydney, NSW, Australia
2512 — D0117 Mechanisms for enhancement
of direction selectivity in the starburst amacrine
cell. Khaldoun Hamade1, W. R. Taylor2, R. G.
Smith1. 1Department of Neuroscience, University
of Pennsylvania, Philadelphia, PA; 2Casey Eye
Institute, Oregon Health and Sciences University,
Portland, OR
2505 — D0110 The study of retinal neurons
in the GlyT2-EGFP transgenic mouse. Annie
Espinal1, 2, J. Perez-Leon1, M. Miranda-Arango2.
1
Quimico-Biologico, UACJ, Juarez, Mexico;
2
Department of Biological Sciences and Border
Biomedical Research Center, University of Texas at
El Paso, El Paso, TX
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
181
Monday Posters
2:45 pm – 4:30 pm
2494 — D0099 Transgene Insertion near
Musashi1 Disrupts Zebrafish Short-Wavelength
Cone Development. Ralph F. Nelson1, S. Rizvi1,
P. M. Cohen1, V. P. Connaughton3, 1, S. Suzuki4,
H. Codore2, S. A. Bergeron2, R. O. Wong4, H.
A. Burgess2. 1Basic Neurosciences Program,
NINDS NIH, Bethesda, MD; 2Unit on Behavioral
Neurogenetics, NICHD NIH, Bethesda, MD;
3
Biology, American University, Washington, DC;
4
Biological Structure, Univeristy of Washington,
Seattle, WA
2499 — D0104 Early Visual Stimulation
Leads to Visual Enhancement. Amanda Mui1,
T. S. Obertone1, M. K. Han2, J. T. Sellers1, M. H.
Aung1, 4, H. Park1, J. H. Boatright1, M. T. Pardue1,
3 1
. Ophthalmology, Emory University, Atlanta,
GA; 2Viral Immunology Center, Georgia State
University, Atlanta, GA; 3Rehabilitation Center of
Excellence, Atlanta VA Medical Center, Atlanta,
GA; 4Neuroscience, Emory University, Atlanta, GA
*CR
2513 – 2535 – Monday – Posters
Exhibit Hall D0118-D0162
Monday, May 06, 2013 2:45 PM-4:30 PM
Immunology/Microbiology
296 Autoimmune Ocular Disease/
Allergy
Moderators: Colleen M. Cebulla and Junko Hori
2513 — D0118 Immune Marker Changes in
Patients with Non-Paraneoplastic Autoimmune
Retinopathy. Jennifer Dailey, B. Liu, Z. Li, S.
Jawad, R. B. Nussenblatt, H. Sen. Laboratory of
Immunology, National Eye Institute, Bethesda, MD
Monday Posters
2:45 pm – 4:30 pm
2514 — D0119 HLA polymorphisms and
autoimmune markers in non-paraneoplastic
autoimmune retinopathy (AIR). Landon Grange,
M. D. Dalal, Y. F. Wang, C. Chan, R. B. Nussenblatt,
H. Sen. National Eye Institute, National Institutes of
Health, Bethesda, MD f
2515 — D0120 Novel Non-invasive in vivo
Quantification of Ocular Inflammation using
Optical Coherence Tomography in Mice. Thomas
C. MacPherson, J. Cao, G. D. Yancopoulos,
S. J. Wiegand. Ophthalmology, Regeneron
Pharmaceuticals, Inc., Tarrytown, NY *CR
2516 — D0121 Optical Coherence
Tomography, Fundus Autofluorescence, and
Fluorescein Angiography in Non-Paraneoplastic
Autoimmune Retinopathy. Monica D. Dalal, L.
Grange, Y. Wang, C. Chan, R. B. Nussenblatt, H.
Sen. Laboratory of Immunology, NEI, Bethesda,
MD
2517 — D0122 Characterizing Peripheral
Biomarkers in Patients with Autoimmune
Retinopathy by Flow Cytometry. Ryan E.
Tsuchida, J. Huang, J. R. Heckenlively, K. T.
Jayasundera. Ophthalmology and Visual Science,
University of Michigan - Kellogg Eye Center, Ann
Arbor, MI
2518 — D0123 Investigation of murine
experimental autoimmune uveoreitinitis
by Optical Coherence Tomography. Kouzo
Harimoto1, M. Ito2, M. Takeuchi1. 1Ophthalmology,
National Defense Medical College, Tokorozawa,
Japan; 2Developmental Anatomy and Regenerative
Biology, National Defense Medical College,
Tokorozawa, Japan
2519 — D0124 Intraocular leukocyte response
after IL-23 intravitreal injection as measured
by intravital microscopy. Hyun Woong Kim1,
C. Metea2, S. R. Planck2, J. T. Rosenbaum2,
3 1
. ophthalmology, Busan Paik Hospital, Inje
University, Busan, Republic of Korea; 2Casey Eye
Institute, Oregon Health & Science University,
Portland, OR; 3Devers Eye Institute, portland, OR
*CR
2520 — D0125 Steroid refractory Th17 cells
have unperturbed glucocorticoid receptor
expression and trafficking. Philippa J. Lait1, 2,
L. P. Schewitz-Bowers1, 2, A. Dhanda2, B. L.
Conway-Campbell2, A. D. Dick1, 2, R. W. Lee1, 2.
1
Inflammation and Immunotherapy Theme, National
Institute for Health Research Biomedical Research
Centre at Moorfields Eye Hospital NHS Foundation
Trust and UCL Institute of Ophthalmology,
University Hospitals Bristol NHS Foundation
Trust, London, United Kingdom; 2Academic Unit
of Ophthal, University of Bristol, Bristol, United
Kingdom *CR
2521 — D0126 Human monocyte subsets
differentially drive T helper cell polarization:
implications for the pathogenesis and treatment
of autoimmune uveitis. Baoying Liu1, A. Dhanda2,
Z. Li1, R. Villasmil1, R. W. Lee2, R. B. Nussenblatt1.
1
Lab Immunology, National Eye Institute/NIH,
Bethesda, MD; 2Inflammation and Immunotherapy
Theme, National Institute for Health Research
Biomedical Research Centre, Moorfields Eye
Hospital NHS Foundation Trust and UCL Institute
of Ophthalmology, University Hospitals Bristol
NHS Foundation Trust and University of Bristol,
Bristol, United Kingdom *CR
2522 — D0127 The spectrum of inflammatory
ocular involvement in systemic lupus
erythematosus in a multidisciplinary uveitis unit.
Laura Pelegrin1, A. Montehermoso1, M. Figueras1,
M. Sainz de la Maza1, B. Sanchez-Dalmau1, V.
Llorens1, B. Molins1, M. Mesquida1, G. Espinosa2,
A. Adan Civera1. 1Ophthalmology, Hospital Clinic
de Barcelona, Barcelona, Spain; 2Autoimmune
Disease, Hospital Clinic de Barcelona, Barcelona,
Spain *CR
2523 — D0128 An unexpected role for the
innate immune receptor NOD2 in suppression
of experimental autoimmune uveitis. Ellen J.
Lee1, 2, J. M. Furtado1, 3, B. Brown1, 2, E. E. Vance1, 2,
J. Sacdal1, 2, V. Bhargava1, 2, J. R. Smith1, P. Silver4,
R. R. Caspi4, H. L. Rosenzweig2, 1. 1Ophthalmology,
Oregon Health & Science University, Portland, OR;
2
Veterans Affairs Medical Center, Portland, OR;
3
Ophthalmology, Federal University of São Paulo,
São Paulo, Brazil; 4Laboratory of Immunology,
National Eye Institute/NIH, Bethesda, MD
2524 — D0129 Exhausted effector memory
CD8 T cells expand in chronic EAU. Joanne
Boldison1, D. A. Copland2, P. J. Lait2, T. K.
Khera2, A. D. Dick2, 1, L. B. Nicholson1, 2. 1Cellular
and Molecular Mediicine, University of Bristol,
Bristol, United Kingdom; 2Academic Unit of
Ophthalmology, University of Bristol, Bristol,
United Kingdom *CR
2525 — D0130 Intratracheal Administration
of Interphotoreceptor Retinoid-Binding
Protein Peptide Suppress Murine Experimental
Autoimmune Uveitis. Toshikatsu Kaburaki1,
X. Jin2, M. Uchiyama2, M. Takamoto1, H.
Nakahara1, H. Kawashima3, S. Amano1, M.
Niimi2. 1Ophthalmology, Univ of Tokyo School of
Medicine, Bunkyo-Ku, Japan; 2Surgery, Teikyo
University School of Medicine, Itabashi-ku,
Japan; 3Ophthalmology, Jichi Medical University,
Shimotsuke-shi, Japan *CR
2526 — D0131 Incidence of Endogenous
Intraocular Inflammation in the Central Tokyo
of Japan for 8 Years from 2004 to 2012. Motoko
Serizawa, Y. Ito, R. Tsukada, H. Takahashi, H.
Taniguchi, J. Hori. Opthalmology, Nippon Medical
School, Bunkyo-ku, Japan
2527 — D0132 Non-infectious Uveitis:
Emotional and personality findings. Matilde
Lopez, C. A. Couto, M. Frick, E. Hurtado Jallaza,
B. A. Schlaen, N. Taubenslag. University of Buenos
Aires, Buenos Aires, Argentina
2528 — D0133 Increased reliability of
diagnosis of ocular cicatricial pemphigoid
using avidin-biotin complex immunoperoxidase
technique. Stephen D. Anesi, P. Artornsombudh,
C. Foster. Massachusetts Eye Research & Surgery
Institution, Cambridge, MA *CR
2529 — D0134 Incidence and Prevalence of
Episcleritis and Scleritis in Northern California.
Grace Honik1, I. G. Wong2, 3, D. C. Gritz1.
1
Montefiore Medical Center, Bronx, NY; 2Proctor
Foundation UCSF, San Francisco, CA; 3Stanford
University, Stanford, CA
2530 — D0135 Application of the diagnostic
criteria of the International Workshop on Ocular
Sarcoidosis in patients with sarcoid uveitis in
a tertiary center. Eva Jakob1, R. Max1, M. D.
Becker2, F. Mackensen1. 1Interdisciplinary Uveitis
Center, University of Heidelberg, Heidelberg,
Germany; 2Eye Hospital, Triemli Hospital, Zürich,
Switzerland *CR
2531 — D0136 Telomere Length of peripheral
leukocytes is shortened in Ocular Sarcoidosis
patients. Ian A. Thompson1, B. Liu1, H. Sen1, B.
Dumitriu2, R. Calado2, S. Hirani1, M. Morgan2,
S. Jawad1, N. Young2, R. B. Nussenblatt1.
1
Immunology, NEI, Bethesda, MD; 2Hematology
Branch, NHLBI, Bethesda, MD
2532 — D0137 Induction of Corneal
Inflammation in the Collagen-Induced Scleritis
Model. Hiroko Taniguchi, Y. Kitahara, J. Hori.
Ophthalmology, Nippon Medical School, Bunkyoku, Japan
2533 — D0138 Factors in the Initial
Presentation to Predict Subsequent Ocular
Complications of Stevens-Johnson Syndrome
and Toxic Epidermal Necrolysis. Shin-yi Chen1,
W. Chung2, D. H. Ma1. 1Ophthalmology, Chang
Gung Memorial Hospital, Taoyuan, Taiwan;
2
Dermatology, Chang Gung Memorial Hospital,
Taoyuan, Taiwan
2534 — D0139 Corneal Pathology Profile in
the Absence of a Functional Type I Interferon
Pathway Following HSV-1 Infection. Ana J.
Chucair-Elliott1, C. D. Conrady2, M. Zheng1, D.
J. Carr1, 2. 1Ophthalmology, Univ of Oklahoma
Hlth Sci Ctr, Oklahoma City, OK; 2Microbiology
and Immunology, Univ of Oklahoma Hlth Sci Ctr,
Oklahoma City, OK
2535 — D0140 IRF-8 Antagonizes Th17
and Tc17 Expansion and Restrains Th17
Inflammatory Responses During Autoimmune
Uveitis. Sung-Hye Kim, C. Yu, B. Marrero, C.
Egwuagu. Laboratory of Immunology, NEI,
Bethesda, MD
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
182
Monday – Posters – 2536 – 2561
2536 — D0141 Evaluation of JAK inhibition
with topical tofacitinib in an experimental
autoimmune uveitis model (EAU). Jing-Feng
Huang1, Y. Zhang2, B. Hirakawa3. 1La Jolla
BioConsulting, San Diego, CA; 2bioTheranostics,
Inc., San Diego, CA; 3Pfizer Inc., San Diego, CA
*CR
2537 — D0142 Characteristics of patients who
attain remission of inflammatory eye disease
following treatment and discontinuation of
methotrexate. Kevin Lai, T. Truong, T. Jenkins,
Z. A. Kresch, S. Kedhar, V. Diaz, J. V. Mauro, C.
Samson. Ophthalmology, New York Eye and Ear
Infirmary, New York, NY *CR
2538 — D0143 Switching Tumor Necrosis
Factor Alpha Antagonists in Patients with
Scleritis. Kourtney Houser, H. B. Leisy, S. M.
Huddleston, R. Walton. Ophthalmology, Hamilton
Eye Institute, University of Tennessee Health
Science Center, Memphis, TN
2540 — D0145 Treatment of Pediatric Uveitis
with Adalimumab: The MERSI Experience.
Claudia P. Castiblanco, C. Foster. Massachusetts
Eye and Research Institution, Cambridge, MA *CR
2541 — D0146 Tumor Necrosis Factor-Alpha
Inhibitors in the Treatment of Non-infectious,
Non-necrotizing Scleritis. Ashwinee Ragam1,
A. M. Kolomeyer1, C. Fang1, Y. Xu1, D. S. Chu1, 2.
1
The Institute of Ophthalmology and Visual
Science, New Jersey Medical School, University of
Medicine and Dentistry of New Jersey, Newark, NJ;
2
Metropolitan Eye Research and Surgery Institute,
Palisades Park, NJ *CR
2542 — D0147 Rituximab in the treatment
of refractory scleritis in patients with
granulomatosis with polyangiitis (Wegener’s
granulomatosis): The Mexican experience.
Juan Carlos Serna-Ojeda1, C. Recillas-Gispert2,
L. F. Flores-Suarez3. 1Institute of Ophthalmology
“Conde de Valenciana”, Mexico City, Mexico;
2
Ophthalmology, I.N.C.M.N.S.Z, Mexico City,
Mexico; 3Instituto Nacional de Enfermedades
Respiratorias, Mexico City, Mexico *CR
2543 — D0148 Treatment Outcomes in
Uveitic Macular Edema with Serous Retinal
Detachment. Stephen M. Huddleston, K. Houser, D.
K. Bennett, R. Walton. Ophthalmology, University
of Tennessee, Memphis, TN
2544 — D0149 Retrospective study of clinical
results in patients diagnosed with pars planitis
treated with via pars plana vitrectomy. Gustavo
Vela, S. Voorduin. Fundación Hospital Nuestra
Señora de la Luz, Mexico City, Mexico
2546 — D0151 Cytosine Arabinoside for the
treatment of Ocular Inflammatory disorders:
a pilot study. Mehrine Shaikh1, 2, S. S. Siddique2,
M. S. Dacey2, C. Foster2. 1Ophthalmology, George
Washington University Hospital, Washington, DC;
2
Ophthalmology, Ocular immunology and uveitis
foundation, Cambridge, MA *CR
2547 — D0152 Pigment Epithelium-Derived
Factor (PEDF) hypersensitivity in CAR & AMD.
Charles E. Thirkill. Ocular Immunology, UC Davis,
Davis, CA
2548 — D0153 PGD2 Promotes Eosinophil
Chemotaxis, Degranulation and Syk
Phosphorylation. Ellen B. Cook1, 2, J. L. Stahl1, 2,
E. A. Schwantes3, S. K. Mathur3, N. Barney1, 2.
1
Ophthalmology and Visual Sciences, University of
Wisconsin, Madison, WI; 2McPherson Eye Research
Institue, University of Wisconsin, Madison,
WI; 3Medicine, Allergy Division, University of
Wisconsin, Madison, WI *CR
2549 — D0154 CCR7 Expression Profiles in
Conjunctival Biopsies from Seasonal Allergic
Conjunctivtis Patients Following Challenge.
Rose Mathew1, A. Mohd Zaki3, G. Galatowicz3,
V. L. Calder3, D. R. Saban1, 2. 1Ophthalmology,
Duke University, School of Medicine, Durham,
NC; 2Immunology, Duke University, School of
Medicine, Durham, NC; 3Ophthalmology, UCL
Institute of Ophthalmology, London, United
Kingdom *CR
2550 — D0155 Effects of D-β-Hydroxybutyrate
(HBA) on eosinophil infiltration in allergic
conjunctivitis model rat. Ryuji Hisamura, S.
Nakamura, T. Imada, K. Tsubota. opthalmology,
Keio University, Shinjuku-ku, Japan *CR
2551 — D0156 An Evaluation of the Effects
of the Repeat Conjunctival Allergen Challenge
(CAC) Model in Various Strains of Albino Mice.
Kortni Violette, L. Belen, J. Brackett, A. Whitlock.
Ora, Inc., Andover, MA *CR
2552 — D0157 Ocular Allergy 2013:A Survey
of Current Trends. Emily Schoemmell, P. J.
Gomes, D. L. Welch. Allergy, Ora, Inc, Adover, MA
*CR
2553 — D0158 Confounding Factors on
Computerized Assessment of Conjunctival
Redness Induced by Conjunctival Allergen
Challenge (CAC). Yesha Raval, J. D. Rodriguez, K.
J. Lane, P. J. Gomes. Allergy, ORA, Andover, MA
*CR, f
2555 — D0160 Modified Allergen Challenge
Induces Chronic Allergic Conjunctivitis that is
alleviated by Treatment with Topical Steroid.
Paulo J. Gomes, E. Angjeli, K. J. Lane, D. L. Welch.
Allergy, ORA, Andover, MA *CR, f
2556 — D0161 Evaluation of Brimonidine
Tartrate for Prevention of Hyperemia Associated
with Allergic Conjunctivitis. Matt J. Chapin1, G.
Horn2, P. J. Gomes1. 1ORA, Andover, MA; 2Eye
Therapeutics, Schaumburg, IL *CR, f
2557 — D0162 Inflammation at the Cellular
Level in the Chronic Allergic Conjunctivitis
Model Using Confocal Imaging. Endri Angjeli, P.
J. Gomes, S. Breton, K. J. Lane. Ora, Inc., Andover,
MA *CR, f
Exhibit Hall D0358-D0408
Monday, May 06, 2013 2:45 PM-4:30 PM
Cornea / Anatomy/Pathology
297 Corneal Epithelium and Imaging II
Moderator: Haydee E. Bazan
2558 — D0358 Effects of smoking on corneal
healing time. Jacquelyn Jetton1, D. Stone1, Y.
Kim2. 1Ophthalmology, University of Oklahoma Dean McGee Eye Institute, Oklahoma City, OK;
2
Biostatistics and Epidemiology, University of
Oklahoma College of Public Health, Oklahoma
City, OK
2559 — D0359 FIH-1/c-kit signaling: a
novel regulator of corneal epithelial glycogen
metabolism. Han Peng1, J. V. Katsnelson1, 3,
W. Yang1, M. A. Brown2, R. M. Lavker1.
1
Dermatology, Northwestern University, Chicago,
IL; 2Microbiology-Immunology, Northwestern
University, Chicago, IL; 3Rush University Medical
School, Chicago, IL
2560 — D0360 Human Corneal Limbal
Epithelial Cells Up-regulate Angiogenic Factors
Following Exposure to Peroxynitrite. Negin
Ashki, A. M. Chan, Y. Qin, M. Kiyohara, L. K.
Gordon. University of California Los Angeles, Los
Angeles, CA *CR
2561 — D0361 Development of a Human
Cultivated Nasal Mucosal Epithelial Cell
Sheet for the Treatment of Severe Ocular
Surface Diseases. Masakazu Kobayashi1, T.
Nakamura1, 2, M. Yasuda3, Y. Hata2, S. Okura1, N.
Okumura1, 2, N. Koizumi1, 2, H. Yasu3, S. Kinoshita2.
1
Biomedical Engineering, Doshisha University,
Kyotanabe, Japan; 2Ophthalmology, Kyoto
Prefectural University of Medicine, Kyoto, Japan;
3
Otolaryngology-Head and Neck Surgery, Kyoto
Prefectural University of Medicine, Kyoto, Japan
*CR
2554 — D0159 Evaluation of the Effects
of Cis-UCA in a Murine Model for Allergic
Conjunctivitis. James T. McLaughlin1, A.
Whitlock1, L. Belen1, J. Brackett1, B. Blank2. 1Ora,
Inc., Andover, MA; 2Laurantis Pharma, Turku,
Finland *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
183
Monday Posters
2:45 pm – 4:30 pm
2539 — D0144 Anti-Tumor Necrosis Factor
Agents in Inflammatory Eye Disease. Careen
Y. Lowder1, M. M. Choudhary2, R. hajj-ali3, S.
K. Srivastava1. 1Cole Eye Institute, Cleveland
Clinic, Cleveland, OH; 2Internal Medicine,
Cleveland Clinic, Cleveland, OH; 3Orthopedics
and Rheumatologic Institute, Cleveland Clinic,
Cleveland, OH *CR
2545 — D0150 Mid-term efficacy and safety
of adalimumab in refractory pediatric uveitis:
a retrospective monocentric study. Benjamin
Penaud1, E. Champion1, C. Fardeau1, P. Le Hoang1,
P. Quartier2, B. Bodaghi1. 11Ophthalmology
department, Pitié-Salpêtrière hospital, Paris, France;
2
Pediatric rheumatology, Necker Hospital, Paris,
France *CR
2562 – 2587 – Monday – Posters
2562 — D0362 Cdc42 expression increases
during corneal epithelial wound healing in vivo
and suppression of its expression delays wound
closure. Swetha Pothula1, G. Chandrasekher1, 2, H.
E. Bazan3. 1Pharmaceutical Sciences, South Dakota
State University, Brookings, SD; 2Internal Medicine,
Sanford School of Medicine of University of South
Dakota, Sioux Falls, SD; 3Neuroscience and Eye
Center, LSU Health Sciences Center, New Orleans,
LA
Monday Posters
2:45 pm – 4:30 pm
2563 — D0363 Overexpression of SIRT1
promotes high glucose-attenuated corneal
epithelial wound healing via p53 regulation of
the IGFBP3/IGF-1R/AKT pathway. Ye Wang, L.
Xie. Shandong Eye Institute, Qingdao, China
2564 — D0364 Conditional Deletion of Notch1
in Mouse Corneal Epithelium Leads to the Loss
of the Epithelial Barrier Function. Asadolah
Movahedan1, N. -. Afshar1, H. M. Sagha1, R. M.
Lavker2, A. R. Djalilian1. 1Ophthalmology & Visual
Sciences, Univ of Illinois at Chicago, Chicago, IL;
2
Dermatology, Northwesrtern University, Chicago,
IL
2565 — D0365 Wnt2 and beta-catenin
signaling are important for corneal wound
healing in diabetic rats. Haijing Sun, F. Wang, I.
Bettahi, F. X. Yu. Wayne state university, Detroit, MI
2566 — D0366 Clinical Factors Can Predict
the Outcome of Autologous Cultivated Limbal
Epithelial Transplantation. Anupam Bagdi1, S.
Basu1, H. Ali2, V. S. Sangwan1. 1Cornea, L V Prasad
Eye Institute, Hyderabad, India; 2Biostatistics and
Clinical Epidemiology, L V Prasad Eye Institute,
Hyderabad, India
2567 — D0367 Utilizing contact lenses as
carriers for human corneal limbal epithelial and
induced pluripotent stem cells. Nir Erdinest, A.
Solomon. Ophthalmology, Hadassah Hebrew Univ
Med Ctr, Jerusalem, Israel
2568 — D0368 Lumican Is Required for
Epithelium Migration during Healing of Corneal
Epithelium Debridement. Jianhua Zhang, V. J.
Coulson-Thomas, Y. Yuan, O. Yamanaka, H. Liu, W.
W. Kao. Ophthalmology, University of Cincinnati,
Cincinnati, OH
2569 — D0369 In Keratoconus are
Epithelial and Stromal Changes Correlated?
Colton Heinrich1, A. P. Kemp1, J. H. Mathew1,
J. Goosey2, 1, J. P. Bergmanson1. 1College of
Optometry, University of Houston, Houston, TX;
2
Ophthalmology, Houston Eye Associates, Houston,
TX *CR
2570 — D0370 Expression of the neural stem
cell marker Hes3 in the rodent and human
ocular surface. Matina Economopoulou1, J.
Masjkur2, F. Raiskup1, M. Karl3, R. H. Funk4,
T. Chavakis2, L. E. Pillunat1, A. AndroutsellisTheotokis2. 1Ophthalmology, University Clinic
Dresden, Dresden, Germany; 2Department of
Internal Medicine (MK3), University Clinic
Dresden, Dresden, Germany; 3Center for
Regenerative Therapies Dresden, Dresden,
Germany; 4Department of Anatomy, University
Clinic dresden, Dresden, Germany
2571 — D0371 Corneal condition and anterior
segment pathology in patients with bullous
keratopathy. Elena Adjievska, P. I. Vassileva, N.
Surchev, T. Hergeldzhieva-Fileva. University Eye
Hospital “Prof. Pashev”, Sofia, Bulgaria
2572 — D0372 HO-2 knockdown delays
wound healing in Human Corneal Epithelial
(HCE) cells by altering the signaling of EGFR
and FAK mediated pathway. Adna Halilovic, D.
Lin, G. Joseph, B. Shkolnik, M. L. Schwartzman.
Pharmacology, New York Medical College,
Valhalla, NY
2573 — D0373 Decreased Incidence of
Perioperative Corneal Injuries Following an
Ophthalmology Educational Initiative For
Anesthesia Providers at an Academic Medical
Center. Amanda L. Ely, I. U. Scott, T. F. Ali, D.
Kerchner, D. Liang, M. Wilkinson. Ophthalmology,
Penn State Hershey Ophthalmology, Hershey, PA
2574 — D0374 Molecular Identification and
Functional Characterization of the Vitamin C
Transporters Expressed by Human Corneal
Epithelial Cells (HCEC). Varun Khurana, A.
Vadlapudi, R. Vadlapatla, D. Pal, A. K. Mitra.
Pharmaceutical Sciences, University of Missouri
Kansas City, Kansas City, MO
2575 — D0375 An animal model for epithelial
downgrowth. Jessica E. Weinstein, M. J. Weiss, J.
L. Goldberg. Ophthalmology, Bascom Palmer Eye
Inst, Univ of Miami, Miami, FL *CR
2576 — D0376 Descriptive Study of Ocular
Surface changes in Patients with Congenital
Glaucoma. Simone Finzi, R. M. Santo, M. Matsuda,
E. W. Oltrogge, M. H. Mendes, F. E. Naves, R. P.
Azevedo, F. Lazar, B. C. Cardoso, A. Betinjane.
Ophthalmology, University of Sao Paulo, Sao
Paulo, Brazil
2577 — D0377 Lacking Muc16 affects intraepithelial differentiation and wound healing in
corneal epithelium in mice. Shizuya Saika1, K.
Shirai1, Y. Okada1, M. Miyajima2, D. Cheon3, R. R.
Behringer3. 1Ophthalmology, Wakayama Medical
University, Wakayama, Japan; 2Animal Center,
Wakayama Medical University, Wakayama, Japan;
3
Genetics, University of Texas M.D. Anderson
Cancer Center, Texas, TX
2578 — D0378 Longitudinal Assessment of
Neuropathy in Diabetes using novel ophthalmic
MARKers (LANDMark): Baseline findings.
Nathan Efron1, 2, N. Pritchard1, 2, K. Edwards1, 2, G.
P. Sampson1, 2, A. Russell3, 4, I. N. Petropoulos4, 5, U.
Alam4, 5, H. Fadavi4, 5, M. Tavakoli4, 5, R. A. Malik4, 5.
1
Institute of Health & Biomedical Innovation,
Queensland University of Technology, Kelvin
Grove, QLD, Australia; 2School of Optometry
and Vision Science, Queensland University of
Technology, Kelvin Grove, QLD, Australia;
3
Department of Diabetes and Endocrinology,
Princess Alexandra Hospital, Woolloongabba,
QLD, Australia; 4School of Medicine, University
of Queensland, St Lucia, QLD, Australia; 5Centre
for Endocrinology and Diabetes, Institute of
Human Development, University of Manchester,
Manchester, United Kingdom
2579 — D0379 Expression of Olfactory
Receptor Genes on Mouse Ocular Surface.
Vladlen Z. Slepak1, A. Pronin1, K. Levay1, Y. Tan2,
D. Velmeshev3, M. Faghihi3, V. I. Shestopalov2.
1
Molecular and Cellular Pharmacology, University
of Miami, Miami, FL; 2Opthalmology, University
of Miami, Miami, FL; 3Psychiatry, University of
Miami, Miami, FL
2580 — D0380 Neuropeptide from trigeminal
nerve promotes the stratification of human
corneal epithelial cells. Ji-Ae Ko, C. Ohki, T.
Chikama, Y. Kiuchi. Department of Ophthalmology,
Hiroshima Univ Grad Sch of Biomed Sci,
Hiroshima, Japan
2581 — D0381 Role of PININ in the Regulation
of Alternative Splicing of Long Non-coding
RNAs. Jeong-Hoon Joo, S. P. Sugrue. Anatomy and
Cell Biology, University of Florida, Gainesville, FL
2582 — D0382 Localisation of Yap/Taz
in corneal epithelia: a marker of mechanosensitivity and role in epithelial homeostasis.
Che J. Connon, R. R. Jones, J. W. Foster. School
of Chemistry, Food and Pharmacy, University of
Reading, Reading, United Kingdom
2583 — D0383 Vitamin D Receptor Knockout
Affects Mouse Corneal Tight Junctions. Mitchell
A. Watsky, R. A. Elizondo, Z. Yin. Physiology, Univ
of Tennessee Health Sci Ctr, Memphis, TN
2584 — D0384 Pharmacological Analysis of
Epidermal Growth Factor Receptor Ligands
on Corneal Epithelial Cells. Brian P. Ceresa1, 2,
J. L. Peterson2. 1Pharmacology and Toxicology,
University of Louisville, Louisville, KY; 2Cell
Biology, University of Oklahoma HSC, Oklahoma
City, OK
2585 — D0385 The Anti-inflammatory
Effects of Resolvin-D1 on Human Corneal
Epithelial Cells. Abraham Solomon, N. Erdinest.
Ophthalmology, Hadassah-Hebrew Univ Med Ctr,
Jerusalem, Israel
2586 — D0386 Non-invasive corneal
examination of individuals with PANK2
mutation. Marine Hovakimyan1, K. Falke1, R. F.
Guthoff1, S. A. Schneider2, H. Zimmermann3, A.
U. Brandt3, F. Paul3, J. Wuerfel3, P. Dusek4, O.
Stachs1. 1Department of Ophthalmology, University
of Rostock, Rostock, Germany; 2Department of
Neurology, University of Kiel, Kiel, Germany;
3
NeuroCure, Charité - University Medicine Berlin,
Berlin, Germany; 4Department of Neurology
and Center of Clinical Neuroscience, Charles
University, Prague, Czech Republic *CR
2587 — D0387 Forme Fruste Keratoconus
Detection by Pattern Analysis of Corneal,
Epithelial, and Stromal Thickness Maps with
Optical Coherence Tomography. Yan Li1, O. Tan1,
R. Brass2, J. L. Weiss3, D. Huang1. 1Ophthalmology,
Oregon Health and Science University, Portland,
OR; 2Brass Eye Center, Latham, NY; 3Gordon &
Weiss Vision Institute, San Diego, CA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
184
Monday – Posters – 2588 – 2608
2588 — D0388 Anterior Segment OCT
Evaluation of Ocular Graft-versus-Host Disease.
Peng Li1, Y. Sun4, 5, Y. Inamoto3, S. Lee3, T. T.
Shen2, 1, R. K. Wang1, 2. 1Bioengineering, University
of Washington, Seattle, WA; 2Ophthalmology,
University of Washington, Seattle, WA; 3Fred
Hutchinson Cancer Research Center, Seattle, WA;
4
Graduate Institute of Clinical Medicine, National
Taiwan University, Taipei, Taiwan; 5Ophthalmology,
Buddhist Tzu-Chi General Hospital, Taipei Branch,
New Taipei, Taiwan *CR
2589 — D0389 Intravital Imaging of the
Cellular Dynamics of LysM-Positive Cells in a
Corneal Suture Mouse Model. Ayaka Koga1, 2, M.
Ueta2, 3, R. Minamiyama1, 2, M. Ishii4, N. Koizumi1, 2,
S. Kinoshita2. 1Biomedical Engineering, Doshisha
University, Kyotanabe, Japan; 2Ophthalmology,
Kyoto Prefectural University of Medicine, Kyoto,
Japan; 3Research Center for Inflammation and
Regenerative Medicine, Doshisha University,
Kyotanabe, Japan; 4Laboratory of Biological
Imaging, WPI-Immunology Frontier Research
Center, Osaka University, Suita, Japan *CR
2591 — D0391 In vivo corneal confocal
microscopy (IVCM) and ocular surface
assessments in patients with mechanical
microkeratome vs femtosecond laser-assisted
LASIK. Munira Hussain, J. Greene, N. Raval, M.
Brumm, S. I. Mian, R. M. Shtein. Ophthalmology
and Visual Sciences, University of Michigan, Ann
Arbor, MI
2592 — D0392 In Vivo Ocular Imaging of the
Anterior Segment of the Canine using HighResolution Optical Coherence Tomography
and Confocal Microscopy. Ann R. Strom1, D.
E. Cortes2, S. M. Thomasy1, P. H. Kass3, V. K.
Raghuanthan1, M. J. Mannis2, C. J. Murphy1, 2.
1
Department of Surgical and Radiological Sciences,
University of California, Davis, Davis, CA;
2
Department of Ophthalmology & Vision Science,
University of California, Davis, CA; 3Department of
Population Health and Reproduction, University of
California, Davis, CA *CR
2593 — D0393 Nerve trunks in the peripheral
cornea and limbus have an intimate association
with macrophages. Yashar Seyed-Razavi1, H.
R. Chinnery2, P. G. McMenamin1. 1Anatomy and
Developmental Biology, Monash University,
Melbourne, VIC, Australia; 2School of Medicine
(Optometry), Deakin University, Melbourne, VIC,
Australia
2594 — D0394 Corneal Curvature Variations
Early After Trabeculectomy. Laura Landi, D.
Musetti, A. Bagnis, M. Papadia, R. Scotto, C.
Traverso. University Eye Clinic, Genova, Italy *CR
2603 — D0403 Comparison of Dual
Scheimpflug imaging parameters in eyes with
forme fruste keratoconus, keratoconus and
low and high ametropia. Maria A. Henriquez,
L. Izquierdo, H. M. Moreyra. Ophthalmology,
Oftalmo-Salud, Lima, Peru
2596 — D0396 Measured Corneal Power and
Astigmatism After LASIK with Spectral Domain
Optical Coherence Tomography (SDOCT)
Reflects Change in Manifest Refraction. Ryan P.
McNabb1, S. Farsiu2, 1, S. Stinnett3, 2, J. A. Izatt1, 2, A.
N. Kuo2. 1Biomedical Engineering, Duke University,
Durham, NC; 2Ophthalmology, Duke University
Medical Center, Durham, NC; 3Biostatistics, Duke
University Medical Center, Durham, NC *CR
2604 — D0404 Structural changes in the
retina and cornea during diabetic neuropathy.
Maxwell Stem1, M. Hussain1, M. Chan2, S. J.
Chiu2, P. Srinivasan2, J. M. Sundstrom1, T. W.
Gardner1, S. Farsiu2, R. Pop-Busui1, R. M. Shtein1.
1
Ophthalmology and Visual Sciences, University
of Michigan, Ann Arbor, MI; 2Biomedical
Engineering, Duke University, Durham, NC *CR
2597 — D0397 Confocal microscopy: New tool
for the follow-up of conjunctival intraepithelial
neoplasia. Vitor S. Maduro1, L. Vieira1, A.
Magriço1, A. Santos1, M. Martins2. 1Ophthalmology
Cornea, CHL-ZC, Lisboa, Portugal; 2Pathology
Department, CHL-ZC, Lisboa, Portugal
2598 — D0398 Phenotypic characterization
of Reis-Bücklers corneal dystrophy.
Qingfeng Liang1, X. Sun1, Z. Pan1, A.
Labbe1, 2. 1ophthalmology, Beijing Institute of
Ophthalmology,Beijing Tongren Eye Center,
Beijing Tongren Hospital, Capital Medical
University, Beijing, China; 2Ophthalmology,
Quinze-Vingts National Eye Center, Paris and
Versailles Saint-Quentin-en-Yvelines University,
Versailles, France., Pairs, France
2599 — D0399 In Vivo Morphology of the
Limbal Palisades of Vogt Correlates with
Progressive Stem Cell Deficiency in AniridiaRelated Keratopathy. Tor P. Utheim1, 2, N.
S. Lagali3, U. Eden3, X. Chen2, R. Riise4, A.
Dellby3, P. Fagerholm3. 1Avdeling for medisinsk
biokjemi, Oslo University Hospital, Oslo, Norway;
2
SynsLaser Kirurgi AS, Oslo, Norway; 3Department
of Clinical and Experimental Medicine, Faculty of
Health Sciences Linköping University, Linköping,
Sweden; 4Department of Ophthalmology, Innlandet
Hospital, Elverum, Norway
2600 — D0400 Laser In Vivo Confocal
Microscopy Demonstrates Diminishment of
Subbasal Nerve Plexus in Early Stage Fuchs
Endothelial Corneal Dystrophy. Shruti Aggarwal,
B. M. Cavalcanti, A. Cruzat, L. Regali, U. V.
Jurkunas, P. Hamrah. Cornea, Ophthalmology,
Massachusetts Eye& Ear Infirmary, Boston, MA
*CR
2605 — D0405 Repeatability of peripheral
(near-limbal) corneal thickness measurements of
Pentacam Scheimpflug corneal topography. Raul
Martin1, S. Jonuscheit2, 3, M. J. Doughty2, A. del Rio
San Cristóbal1, L. J. Mackintosh2, D. MacTaggart2,
M. Hiscock2. 1Optometry Research Group, IOBA
Eye Institute, Valladolid, Spain; 2Vision Sciences,
Department of Life Sciences, Glasgow Caledonian
University, Glasgow, United Kingdom; 3Diabetes
Research Group, Institute for Applied Health
Research, Glasgow Caledonian University,
Glasgow, United Kingdom *CR
2606 — D0406 Comparison of corneal shape
and ocular aberrations in eyes with forme
fruste keratoconus to that of normal cornea.
Ryotaro Ueki1, 2, N. Maeda1, M. Fuchihata1, S.
Koh1, T. Kitaoka2, K. Nishida1. 1Ophthalmology,
Osaka Univ School of Medicine, Osaka-Shi,
Japan; 2Ophthalmology, Nagasaki Univ School of
Medicine, Nagasaki-Shi, Japan *CR
2607 — D0407 Depth resolved fluorescence
lifetime of fluorescein across the cornea. Yueren
Wang1, S. Peters2, M. Hammer2, Y. Jiang1, T.
Kemerly1, U. B. Kompella3, S. P. Srinivas1. 1Indiana
University, Bloomington, IN; 2University of Jena,
Jena, Germany; 3University of Colorado, Denver,
CO *CR
2608 — D0408 Analysis of Interocular Ocular
Surface Aberrations Using Surface Aberrometry.
Varadharajan Jayakumar, N. Hutchings, V.
Lakshminarayanan, L. W. Jones. Optometry and
Vision Science, University of Waterloo, Waterloo,
ON, Canada *CR
2601 — D0401 New Diagnostic Parameters
in Staging Limbal Stem Cell Deficiency Using
In Vivo Laser Scanning Confocal Microscopy.
Eric H. Chan1, M. N. Nakatsu2, S. X. Deng2. 1David
Geffen School of Medicine at UCLA, Los Angeles,
CA; 2Cornea Division, Jules Stein Eye Institute, Los
Angeles, CA
2602 — D0402 Incidence and type of higher
order corneal aberrations in the cataract
population. Neil M. Vyas1, B. A. Henderson2.
1
Ophthalmology, Boston University, Boston, MA;
2
Ophthalmic Consultants of Boston, Boston, MA
*CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
185
Monday Posters
2:45 pm – 4:30 pm
2590 — D0390 Superior and Inferior Limbal
Epithelial and Vascular Structure Characterized
Using Ultra-High Resolution Optical Coherence
Tomography. Emmanuel B. Alabi1, N. Hutchings1,
Y. Feng1, K. K. Bizheva2, T. L. Simpson1. 1School
of Optometry and Vision Science, University of
Waterloo, Waterloo, ON, Canada; 2Physics and
Astronomy, University of Waterloo, Waterloo, ON,
Canada *CR
2595 — D0395 Changes in Corneal
Densitometry and Visual Function Following
Collagen Crosslinking. Fiorella K. Saponara,
L. H. Suh, S. L. Trokel. Ophthalmology & Visual
Sciences, Columbia University, Kaohsiung, Taiwan
*CR
2609 – 2611 – Monday – Lectures
6E
Monday, May 06, 2013 5:30 PM-6:30 PM
299A Proctor Award and Lecture
The Proctor Award is presented annually to
recognize outstanding research in the basic or
clinical sciences as applied to ophthalmology.
— 5:30 Introduction. King-Wai Yau.
Neuroscience, Johns Hopkins School of Med,
Baltimore, MD
2609 — 5:35 Timing is Everything: GTPase
Regulation in Phototransduction. Vadim Y.
Arshavsky. Ophthalmology, Duke University,
Durham, NC
Monday Lectures
5:30 pm – 7:30 pm
2610 — 6:00 Timing is Everything: GTPase
Regulation in Phototransduction. Theodore G.
Wensel. Biochemistry, Baylor College of Medicine,
Houston, TX
6E
Monday, May 06, 2013 6:45 PM-7:30 PM
299B Weisenfeld Award and Lecture
The Weisenfeld Award is presented annually
to an individual in recognition of distinguished
scholarly contributions to the clinical practice of
ophthalmology.
— 6:45 Introduction. Martin B. Wax. PanOptica
Inc, Westlake, TX
2611 — 6:50 Soaring Aspirations - Lessons
from My Mentors and Colleagues. David L.
Epstein. Department of Ophthalmology, Duke Eye
Center, Durham, NC
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
186