PCL Department Publications - 2002
"A,B,C,D"
Francis J, Jung B, Zhang G, Cheng J, Ho W, Burnham WM, Eubanks JH: Kindling induces the
mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Neuroscience
113: 79-87 (2002).
Thavendiranathan P, Chow C, Cunnane S, Burnham WM: The effect of the classic ketogenic
diet on animal seizure models. Brain Research 959: 206-213 (2002).
Edwards HE, Dortok D, Tam J, Won D, Burnham WM: Prenatal Stress Alters Seizure
Thresholds and the Development of Kindled Seizures in Infant and Adult Rats. Hormones
Behavior 42: 437-447 (2002).
Likhodi SS, Burnham WM: On the anticonvulsant effect of acetone and the ketogenic diet.
Epilepsia 43: 1596 (2002).
Burnham WM : Epilepsy. In: Encyclopedia of Cognitive Science. Nature publishing group.
2: 1-7(2002).
Burnham WM : Why are complex partial seizures intractable? In: Burnham WM, Carlen PL,
and Hwang PA, (eds). Intractable Seizures Diagnosis, Treatment and Prevention. Plenum Press,
2002, New York, pp. 107-110
Tremblay LK, Naranjo CA, Cardenas L, Herrmann N, Busto UE: Probing brain reward system function
in Major Depressive Disorder: Altered response to d-amphetamine. Arch Gen Psychiatry 59: 409-416
(2002).
Cardenas L, Tremblay LE, Naranjo CA, Herrmann N, Zack M, Busto UE: Brain reward system activity
in major depression and comorbid nicotine dependence. J Pharmacol Exp Ther 302: 1265-1271
(2002).
"E,F,G"
George SR, O'Dowd BF, Lee SR: G-protein-coupled receptor oligomerization and its potential
for drug discovery. Nature Reviews Drug Discovery 1: 808-820 (2002).
Lamey M, Thompson M, Varghese G, Chi H, Sawzdargo M, George SR, O'Dowd BF: Distinct
residues in the carboxyl tail mediate agonist-induced desensitization and internalization of the
human dopamine D-1 receptor. J Biol Chem 277:9415-9421 (2002).
PCL Publications (2002) – Page 1
Levac BAR, O'Dowd BF, George SR:Oligomerization of opioid receptors: generation of novel
signaling units. Curr Opin Pharmacol 2: 76-81 (2002).
Lee DK, George SR, O'Dowd BF: Novel G protein-coupled receptor genes expressed in the
brain: Continued discovery of important therapeutic targets. Expert Opin Therap Targets 6:185202, (2002).
Demchyshyn LL, O'Dowd BF, George SR: Structure of mammalian D1 and D5 dopamine
receptors and their function and regulation in cells. In: Sidhu A, Laruelle M, Vernier P, (eds).
Dopamine Receptors and Transporters. Marcel Dekker, New York, 2002.
Lam V, Findley HW, Reed JC, Freedman MH and Goldenberg GJ: Comparison of DR5 and
Fas expression levels relative to the chemosensitivity of acute lymphoblastic leukemia cell lines.
Leukemia Res. 26: 503-513 (2002).
Basrani B, Santos JM, Tjaderhane L, Grad H, Gorduysus O, Huang J, Lawrence HP, Friedman
S: Substantial antimicrobial activity in chlorhexidine-treated human root dentin. Oral Surg Oral
Med Oral Pathol Oral Radiol Endon 94: 240-245 (2002).
"H"
Haas DA: An update on analgesics for the management of acute postoperative dental pain. J
Can Dental Assoc 68: 476-482 (2002).
Haas DA: An update on local anesthetics in dentistry. J Can Dental Assoc 68: 546-551 (2002).
Shojaei AR, Haas DA: Local anesthetic cartridges and latex allergy: a literature review. J Can
Dental Assoc 68: 603-607 (2002).
Haas DA: Emergency Drugs. Dental Clin North Amer 46: 815-830 (2002).
Haas DA: Drugs in Dentistry. Compendium Pharmac Specialties L26-29 (2002).
Rosemond E, Peltekova V, Naples M, Thogersen H, Hampson DR: Molecular determinants of
high affinity binding to group III metabotropic glutamate receptors. J Biol Chem 277: 73337340 (2002).
PCL Publications (2002) – Page 2
Harper PA, Wong JMY, Lam MSM, Okey AB: Polymorphisms in the human AH receptor.
Chem-Biol Interactions 141:161-187 (2002).
"I, J"
Jorge-Nebert LF, Eichelbaum M, Griese E-U, Inaba T, Arias TD: Analysis of six SNPs of
NAT2 in Ngawbe and Embera Amerindians of Panama and determination of the Embera
acetylation phenotype employing caffeine. Pharmaogenetics 12: 39-45 (2002).
Fukuen S, Fukuda T, Maune H, Ikenaga Y, Yamamoto I, Inaba T, Azuma J: Novel detection
assay by PCR-RFLP and frequency of CYP3A5 SNPs, CYP3A5*3 and *6, in a Japanese
population. Pharmacogenetics 12: 331-334 (2002).
Matsumoto S, Ding LR, Ishii M, Fischer NE, Inaba T: The interaction of human and bovine
serum proteins with CYP3A in human liver microsomes: inhibition of testosterone 6betahydroxylation by albumin, alpha-globulins, alpha-1-acid glycoprotein and gamma-globulins.
Tox Letters 136: 33-41 (2002).
Fukuen S, Fukuda T, Matsuda H, Sumida A, Yamamoto I, Inaba T, Azuma J. Identification of
the novel splicing variants for the hPXR in human livers. Biochem Biophys Res Comm 298: 433438 (2002).
Costei A, Kozer E, Ho T, Ito S, Koren G. Perinatal outcome following third trimester exposure
to paroxetine. Arch Ped Adoles Med. 156:1129-1132 (2002).
"K"
Khanna JM, Morato GS, Kalant H: Effect of NMDA antagonists, antagonists, an NMDA
agonist, and serotonin depletion on acute tolerance to ethanol. Pharmacol Biochem Behav: 72:
291-298 (2002).
Kalant H: Editorial: Tolérance et dépendance - une entité commune, ou distinctive pour chaque
drogue? Alcoologie et Addictologie 24: 204-206 (2002)
Kalant H: Addiction. In: Adelman G, Smith BH (eds.). Encyclopedia of Neuroscience, 3rd ed.
New York: Elsevier Science (2002).
PCL Publications (2002) – Page 3
Kalow W: Both populations and individuals are evolutionary targets: Pharmacogenomic and
cultural indicators. The Pharmacogenomics Journal. 2: 12-19 (2002).
Kalow W: Pharmacogenetics and personalized medicine. Fund Clin Pharmacol 16: 337-342
(2002).
Sy SKB, Ciaccia A, Li W, Roberts EA, Okey A, Kalow W, Tang BK: Modeling of human
hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal
distribution in CYP3A4 gene expression. Eur J Clin Pharmacol 58: 357-365 (2002).
Sy SKB, Tang BK, Johnston JA, Roberts EA, Kalow W: Multivariate cluster analysis of a
human hepatic cytochrome P450 database. Eur J Clin Pharmacol 58: 554-562 (2002).
Khanna JM, Morato GS, Kalant H: Effect of NMDA antagonists, antagonists, an NMDA
agonist, and serotonin depletion on acute tolerance to ethanol. Pharmacol Biochem Behav 72:
291-298 (2002).
Kish SJ: How strong is the evidence that brain serotonin neurons are damaged in human users
of ecstasy? Pharmacol Biochem Behav 71: 845-855 (2002).
Ross BM, Moszczynska A, Peretti FJ, Adams V, Schmunk GA, Kalasinsky KS, Ang L,
Mamalias N, Turenne SD, Kish SJ: Decreased activity of brain phospholipid metabolic
enzymes in human users of cocaine and methamphetamine. Drug Alcohol Depend 67: 73-79
(2002).
Fitzmaurice P, Ang L, Guttman M, Rajput A, Furukawa Y, Kish SJ: Brain aconitase activity is
not decreased in progressive supranuclear palsy. Neurology 59:137-138 (2002).
Furukawa Y, Kapatos G, Haycock JW, Worsley J, Wong H, Kish SJ, Nygaard TG: Brain
biopterin and tyrosine hydroxylase in asymptomatic dopa-responsive dystonia. Annals
Neurology 51:637-641 (2002).
Furukawa Y, Vigouroux S, Wong H, Guttman M, Rajput AH, Ang L, Briand M, Kish SJ, Briand
Y: Brain proteosomal function in sporadic Parkinson=s disease and related disorders. Annals
Neurology 51:779-782 (2002).
PCL Publications (2002) – Page 4
Koren G, Cohn T, Chitayat D, Kapur B, Remington G, Reid DM, Zipursky RB: Use of
Atypical Antipsychotics During Pregnancy and the Risk of Neural Tube Defects in Infants. Am J
Psychiatry. 159: 136-137 (2002).
Koren G, Cohn T, Chitayat D, Kapur B, Remington G, Reid DM, Zipursky RB: Use of atypical
antipsychotics during pregnancy and the risk of neural tube defects in infants. Op cit. 159: 136-7
(2002)
Nulman I, Rovet J, Stewart DE, Wolpin J, Pace-Asciak P, Shuhaiber S, Koren G: Child
development following exposure to TCA of fluoxetine throughout fetal life:a prospective,
controlled study. Op cit. 159: 1189-95 (2002).
Koren G, Boskovic R, Hard M, Maltepe C, Navioz Y, Einarson A: Motherisk-PUQE
(pregnancy-unique quantification of emesis and nausea) scoring system for nausea and vomiting
of pregnancy. Am J Obstet Gynecol. 185: S228-31 (2002).
Magee LA, Chandra K, Mazzotta P, Stewart D, Koren G, Guyatt GH: Development of a
health-related quality of life instrument for nausea and vomiting of pregnancy. Op cit 185:
S323-8 (2002).
Koren G, Levichek Z: The teratogenicity of drugs for nausea and vomiting of pregnancy:
perceived versus true risk. Op cit. 185: S248-52 (2002).
Magee LA, Mazzotta P, Koren G: Evidence-based view of safety and effectiveness of
pharmacologic therapy for nausea and vomiting of pregnancy. (NVP). Op cit. 185: S256-61
(2002
Kozer E, Nikfar S, Costei A, Boscovic R, Nulman I, Koren G: Aspirin consumption during the
first trimester of pregnancy and congenital anomalies: A meta-analysis. Op cit. 187: 1623-30
(2002).
Koren G: Drinking alcohol while breastfeeding. Will it harm my baby? Can Fam Physician.
48:39-41 (2002).
Chandra K, Einarson A, Koren G: Taking ginger for nausea and vomiting during pregnancy. Op
cit 48:1441-2 (2002).
Goldman RD, Koren G: Influenza vaccination during pregnancy. Op cit 48: 1768-9 (2002).
Yagev Y, Koren G: Eating fish during pregnancy. Risk of exposure to toxic levels of
methylmercury. Op cit 48:1619-21 (2002).
Levichek Z, Atanackovic G, Oepkes D, Maltepe C, Einarson A, Magee L, Koren G: Nausea and
vomiting of pregnancy. Evidence based treatment algorithm. Op cit. 48: 267-8 (2002).
Liaschko A, Koren G: Cystic fibrosis during pregnancy. Op cit 48: 463-4 (2002).
PCL Publications (2002) – Page 5
Abadi S, Einarson A, Koren G: Use of warfarin during pregnancy. Op cit 48: 695-7 (2002).
Einarson A, Koren G: Bacterial vaginosis during pregnancy. Should we screen for and treat it?
Op cit. 48: 877-8 (2002).
Einarson A, Portnoi G, Koren G: Update on Motherisk. Seven years of questions and answers.
Op cit. 48:1301-4 (2002).
Ratnapalan S, Koren G: Taking ACE inhibitors during pregnancy. Is it safe? Op cit 48:1047-9
(2002).
Koren G, Chan D, Klein J, Karaskov T: Estimation of fetal exposure to drugs of abuse,
environmental tobacco smoke, and ethanol. Ther Drug Monit. 24: 23-25 (2002).
Kozer E, Parvez S, Minassian BA, Kobayashi J, Verjee Z, Koren G: How high can we go with
phenytoin? Op cit 24: 386-9 (2002).
Kapur B, Soldin OP, Koren G: Potential prevention of neural tube defects by assessment of
women of childbearing age through monitoring of folate. Op cit 24: 628-30 (2002).
Nevin AC, Parshuram C, Nulman I, Koren G, Einarson A: A survey of physicians knowledge
regarding awareness of maternal alcohol use and the diagnosis of FAS. BMC Fam Pract. 3: 2
(2002).
Koren G: Trends of medication errors in hospitalized children. J Clin Pharmacol 42: 707-10
(2002).
Koren G, Money D, Boucher M, Aoki F, Petric M, Innocencion G, Wolosk M, Remple V,
Pelland F, Geist R, Ho T, Bar-Oz B, Loebstein R: Serum concentrations, efficacy, and safety of a
new intravenously administered varicella zoster immune globulin in pregnant women. Op cit
42: 267-74 (2002).
Schmid R, Koren G, Klein J, Katz J: The stability of a ketamine-morphine solution. Anesth
Analg. 94: 898-900 (2002).
Taddio A, Gurguis MG, Koren G: Lidocaine-Prilocaine Cream Versus Tetracaine Gel for
Procedural Pain in Children. Ann Pharmacother. 36:687-692 (2002).
Hemels ME, Koren G, Einarson TR: Increased use of antidepressants in Canada: 1981-2000. Op
cit 36:1375-9 (2002).
Koren G: SSRI's in Pregnancy-Are they safe? Pediatr Res. 51: 424-425 (2002).
Koren L, Mokady O, Karaskov T, Koren G, Geffen E: A novel method using hair for
determining hormonal levels in wildlife. Animal Behavior 63: 403-6 (2002).
PCL Publications (2002) – Page 6
Koren G, Klinger G, Ohlsson A: Fetal Pharmacotherapy. Drugs 62:757-73 (2002).
Bailey B, Forget S, Koren G: Pregnancy outcome of women who failed appointments at a
teratogen information service clinic. Reprod Toxicol. 16: 77-80 (2002).
Koren G: Ethical framework for observational studies of medicinal drug exposure in pregnancy.
Teratology 65:191-5 (2002).
Koren G: Comment on antiepileptics and antipsychotics. Op cit 66: 273 (2002).
Sgro MD, Barozzino T, Mirghnai HM, Moscato L, Akoury H, Koren G, Chitayat DA:
Pregnancy outcome post renal transplantation. Op cit. 65: 5-9 (2002).
Aleksa K, Koren G: Ethical issues in including pediatric cancer patients in drug development
trials. Pediatr Drugs. 4: 257-65 (2002).
Freedman B, Koren G: Reliability of maternal reporting in identifying major congenital
malformations. Vet Hum Toxicol. 44:180-1 (2002).
Nikfar S, Abdollahi M, Moretti ME, Magee LA, Koren G: Use of proton pump inhibitors during
pregnancy and rates of major malformations: a meta-analysis. Dig Dis Sci. 47: 1526-9 (2002).
Koren G: Adverse effects of assisted reproductive technology and pregnancy outcome. Pediatr
Res. 52: 136 (2002).
Chandra K, Magee L, Koren G: Discordance between physical symptoms versus perception of
severity by women with nausea and vomiting in pregnancy. (NVP). BMC Pregnancy
Childbirth. 2: 5 (2002).
Von Dadelszen P, Magee LA, Lee SK, Stewart SD, Simone C, Koren G, Walley KR, Russell
JA: Activated protein C in normal human pregnancy and pregnancies complicated by severe
preeclampsia: a therapeutic opportunity? Crit Care Med. 30:1883-92 (2002).
Till C, Koren G, Rovet JF: Agreement between prospective and retrospective reports of
maternal exposure to chemicals during pregnancy. J Occup Environ Med. 44: 708-13 (2002).
Kozer E, Scolnik D, Macpherson A, Keays T, Shi K, Luk T, Koren G: Variable associated with
medication errors in pediatric emergency medicine. Pediatrics 110: 737-42 (2002).
Geshundheit B, Kirby M, Lau W, Koren G, Abdelhaleem M: Thrombocytopenia and
megakaryocyte dysplasia: an adverse effect of valproic acid treatment. J Pediatr Hematol
Oncol. 24: 589-90 (2002).
Goldman RD, Koren G: Biologic markers of pain in the vulnerable infant. Clin Perinatol. 29:
415-25 (2002).
PCL Publications (2002) – Page 7
Forman R, Koren G, Shear NH: Erythema mulitforme, Stevens-Johnson syndrome and toxic
epidermal necrolysis in children: a review of 10 years' experience. Drug Safety 25: 965-72
(2002).
Kagan-Kreiger S, Selby P, Vohra S, Koren G: Paternal alcohol exposure and turner syndrome.
Alcohol. 37: 613-7 (2002).
Costei AM, Kozer E, Ho T, Ito S, Koren G: Perinatal outcome following third trimester
exposure to paroxetine. Arch Pediatr Adolesc Med. 156:1129-32 (2002).
Klein J, Chan D, Koren G: Neonatal hair analysis as a biomarker for in utero alcohol exposure.
N Engl J Med. 347: 2086 (2002).
Kozer E, Scolnik D, Keays T, Shi K, Luk T, Koren G: Large errors in the dosing of
medications for children. Op cit 346:1175-6 (2002).
Stempak D, Gammon J, Klein J, Koren G, Baruchel S: Single-dose and steady state
pharmacokinetics of celecoxib in children. Clin Pharmacol Ther. 72: 490-7 (2002).
"L"
Lanctôt KL, Herrmann N, van Reekum R, Eryavec G, Naranjo CA: Gender, aggression and
serotonergic function are associated with response to sertraline for behavioral disturbances in
Alzheimer's disease. Int J Ger Psychiatry 17:531-41 (2002).
Schaffer A, Levitt AJ, Hershkop SK, Oh P, MacDonald C, Lanctôt KL: Utility scores of
symptom profiles in major depression. Psychiatry Res 110:189-197 (2002).
Oh PI, Lanctôt KL, Yoon A, Lee DSC, Paes BA, Simmons BS, Parison D, Manzi P, on behalf
of the COMPOSS Investigators: Palivizumab prophylaxis for respiratory syncytial virus in
Canada: utilization and outcomes. Pediatric Infect Dis J 21(6):512-8 (2002).
Paradiso-Hardy FL, Papastergiou J, Lanctôt KL, Cohen EA: Thrombotic thrombocytopenic
purpura associated with clopidogrel: Further evaluation. Can J Cardiol. 18:771-3 (2002).
Lanctôt KL, Herrmann N, Eryavec G, van Reekum R, Reed K, Naranjo CA: Central
serotonergic activity is related to the aggressive behaviours of Alzheimer's disease.
Neuropsychopharmacology 27: 647-655 (2002).
Optenberg SA, Lanctôt KL, Herrmann N, Oh PI: Antidepressant selection, healthcare resource
consumption and costs in a large workplace environment - U.S. and Canadian perspectives. Clin
Drug Invest. 22(10): 685-94 (2002).
PCL Publications (2002) – Page 8
Dergal JM, Gold JL, Laxer DA, Lee MSW, Binns MA, Lanctôt KL, Freedman M, Rochon PA:
Potential interactions between herbal medicines and conventional drug therapies used by older
adults attending a memory clinic. Drugs Aging 19:879-86 (2002).
Lê AD: Effects of nicotine on alcohol consumption. Alcohol Clin Exp Res. 26:1915-6 (2002).
McBride W, Lê AD, Noronha A: Central nervous system mechanisms in alcohol relapse.
Alcohol Clin Exp Res. 26:280-6 (2002).
Lê AD, Harding S, Juzytsch W, Fletcher PJ, Shaham Y: The role of corticotropin-releasing
factor in the median raphe nucleus in relapse to alcohol. J Neurosci. 22:7844-9 (2002).
Lê AD, Shaham Y: Neurobiology of relapse to alcohol in rats. Pharmacol Ther. 94:137-56
(2002).
"M"
Yeung JY, Canning KJ, Zhu G, Pennefather P, MacDonald JF, Orser BA: Tonically activated
GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for
extracellular GABA. Mol Pharmacol 63: 2-8 (2002).
Kotecha SA, Oak JN, Jackson MF, Perez Y, Orser BA, Van Tol HM, MacDonald JF: A D2
class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor
transmission. Neuron. 35: 1-20 (2002).
Meng Y, Zhang Y, Tregoubov V, Janus, C, Cruz L, Jackson M, Lu WY, MacDonald JF, Wang
JY, Falls DL, Jia Z: Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.
Neuron. 35: 121-33 (2002).
Caraiscos VB, Mihic SJ, MacDonald JF, Orser BA: Tyrosine kinases enhance the function of
glycine receptors in rat hippocampal neurons and human alpha(1)beta glycine receptors. J
Physiol. 539: 495-502 (2002).
Kotecha SA, MacDonald JF: Signaling molecules and receptor transduction cascades that
regulate NMDA receptor-mediated synaptic transmission. Int Rev Neurobiol vol 54, (2002).
Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW: Oxidative
damage increases with age and β-amyloid deposition in a canine model of human brain aging. J
Neurochem 82: 375-81 (2002).
PCL Publications (2002) – Page 9
Chan, ADF, Nippak P, Murphey H, Ikeda-Douglas C, Muggenberg B, Head E, Cotman CW,
Milgram NW: Visuospatial Impairments in Aged Canines: The Role of Cognitive-Behavioral
Flexibility. Behav Neurosci 116: 443-54 (2002).
Siwak CT, Murphey HL, Muggenburg BA, Milgram NW: Age-Dependent Decline in
Locomotor Activity in Dogs is Environment Specific. Physiol and Behav 75: 65-70 (2002).
Milgram NW, Zicker E, Head BA, Muggenburg H, Murphey C, Ikeda-Douglas, Cotman CW:
Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol
Aging 23: 805 (2002).
Cotman CW, Head E, Bruce A, Muggenburg S, Zicker and Milgram NW: Brain Aging in the
Canine: A Diet Enriched in Antioxidants Reduces Cognitive Dysfunction. Neurobiol Aging 23:
737 (2002).
Milgram NW, Head E, Muggenburg B, Holowachuk D, Murphey H, Estrada CJ, Ikeda-Douglas
S C, Zicker and C.W. Cotman: Landmark discrimination learning in the dog: effects of age, an
antioxidant fortified diet, and cognitive Strategy. Neurosci Biobehav Rev 26: 679-95 (2002).
Cheung R, Kassirian S, Mitchell J: Diurnal regulation of the G protein G11a and guanine
nucleotide-regulated phospholipase C activity in rat retina. Exp Eye Res. 75: 371-374 (2002).
Cheung R, Mitchell J: Mechanisms of regulation of G11a protein by dexamethasone in
osteoblastic UMR-106-01 cells. Am J Physiol. 282: E24-E30 (2002).
Erclik M, Mitchell J: The role of protein kinase C-d in parathyroid hormone stimulation of
IGF-binding protein-5 mRNA expression in UMR-106-01 cells. Am J Physiol. 282: E534-E541
(2002).
Mittmann N, Jivraj F, Wong A, Yoon A. Meta-analysis of oral fluoroquinolones in the
treatment of community-acquired pneumonia and acute exacerbations of chronic bronchitis. Can
J Infect Dis 13: 293-300 (2002).
Iskedjian M, Einarson TR, MacKeigan LD, Shear NH, Addis A, Mittmann N, Ilersich AL.
Relationship between daily dose frequency and adherence to antihypertensive pharmacotherapy:
Evidence from a meta-analysis. Clin Therap 24:302-316 (2002).
Chung P, Parker C, Panzarella T, Gospodarowicz MK, Jewett MAS, Milosevic M, Catton CN,
Bayley AJ, Tew B, Moore MJ, Sturgeon JFG, Warde P: Surveillance in stage I testicular
seminoma B risk of late relapse. Can J Urol. 9: 1637-1640 (2002.).
PCL Publications (2002) – Page 10
Juffs HG, Moore MJ, Tanncok IF: The role of systemic chemotherapy in the management of
muscle-invasive bladder cancer. Lancet Oncology 3: 738-747 (2002).
Belanger K, Moore MJ, Baker S, Dionne J, Maclean M, Jolivet J, Siu L, Soulieres D, Wainman
N, Seymour L: Phase I and pharmacokinetic study of a novel L-nucleoside troxacitabine given
as a 30 minute infusion every 21 days. J Clin Oncol. 20:2567-2574 (2002).
Moore MJ: Pancreatic cancer: what the oncologist can offer for palliation. Can J Gastroenterol.
16:121-4 (2002).
Stadler WM, Hayden A, von der Maase H, Roychowdry D, Dogliotti L, Donald Kaufmann D,
Moore MJ: Long Term survival in patients treated with gemcitabine plus cisplatin for advanced
transitional cell cancer. Urol Oncol. 7:153-7 (2002).
Tolcher AW, Reyno L, Venner PM, Ernst SD, Moore MJ, Geary RS, Chi K, Hall S, Walsh W,
Dorr, A, Eisenhauer E: A randomized phase II and pharmacokinetic study of the antisense
oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone refractory prostate cancer.
Clin Cancer Res. 8:2530-2535 (2002).
Michael M, Hedley D, Oza A, Feld R, Pintilie M, Goel R, Maroun J, Jolivet J, Fields A, Lee IM,
Moore MJ: The palliative benefit of irinotecan in 5-fluorouracil-refractory colorectal cancer: its
prospective evaluation by a Multicenter Canadian Trial. Clin Colorectal Cancer 2: 93-101
(2002).
"N"
Tremblay LK, Naranjo CA, Cardenas L, Herrmann N, Busto UE: Probing the brain reward
system in major depressive disorder: Altered response to d-amphetamine. Archives of General
Psychiatry 59: 409-416 (2002).
Lanctot KL, Herrmann N, van Reekum R, Eryavec G, Naranjo CA: Gender, aggression and
serotonergic function are associated with response to sertraline for behavioral disturbances in
Alzheimer's disease. Int J Ger Psychiatry 17: 531-541 (2002).
Naranjo CA, Chu AY, Tremblay LK: Neurodevelopmental liabilities in alcohol dependence;
central serotonin and dopamine dysfunction. Neurotox Res 4: 343-361 (2002).
Lanctot KL, Herrmann N, Eryavec G, van Reekum R, Reed K, Naranjo CA: Central
serotonergic activity is related to the aggressive behaviours of Alzheimer's disease. Am J
Psychiatry 27: 646-654 (2002).
Cardenas L, Tremblay LK, Naranjo CA, Herrmann N, Zack M, Busto UE. Brain reward system
activity in major depression and comorbid nicotine dependence. J Pharmacol Exp Therap 302:
1265-1271 (2002).
PCL Publications (2002) – Page 11
Sproule BA, Naranjo CA, Turksen IB. Fuzzy pharmacology: Theory and applications. Trends
in Pharmacological Sciences 23: 412-417 (2002).
Kilic K, Sproule BA, Turksen IB, Naranjo CA. Fuzzy system modeling in pharmacology. An
improved algorithm. Fuzzy Sets and Systems 130: 253-264 (2002).
Neuman MG, Benhamou JP, Bourliere M, Ibrahim A, Malkiewicz I, Asselah T, MartinotPeignoux M, Shear NH, Katz GG, Akremi R, Benali S, Boyer N, Lecomte L, Le Breton V, Le
Guludec G, Marcellin P: Serum tumour necrosis factor-alpha and transforming growth factorbeta levels in chronic hepatitis c patients are immunomodulated by therapy. Cytokine. 17:108-17
(2002).
Neuman M, Angulo P, Malkiewicz I, Jorgensen R, Shear N, Dickson ER, Haber J, Katz G,
Lindor K: Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of
liver damage in primary biliary cirrhosis. J Gastroenterol Hepatol. 17:196-202 (2002).
Popat A, Shear NH, Malkiewicz I, Thomson S, Neuman MG: Mechanism of Impila (Callilepis
laureola)-induced cytotoxicity in Hep G2 cells. Clin Biochem. 35:57-64 (2002).
Neuman MG, Benhamou JP, Malkiewicz IM, Ibrahim A, Valla DC, Martinot-Peignoux M,
Asselah T, Bourliere M, Katz GG, Shear NH, Marcellin P: Kinetics of serum cytokines reflect
changes in the severity of chronic hepatitis C presenting minimal fibrosis. J Viral Hepatitis
9:134-40 (2002).
Neuman MG: Apoptosis in liver disease. Rom J Gastroenterol. 11: 3-7 (2002).
Neuman MG, Haber JA, Malkiewicz IM, Cameron RG, Katz GG, Shear NH: Ethanol signals
for apoptosis in cultured skin cells. Alcohol 26:179-90 (2002).
Neuman MG, Thompson S, Malkiewicz IM, Popat A, Shear NH: Response to the editor for
Mechanism of Impila (Callilepis laureola)-induced cytotoxicity in Hep G2 cells. Clin Biochem.
35:179-80 (2002).
Neuman MG, Cameron RG, Haber JA, Katz GG, Blendis LM: An electron microscopic and
morphometric study of ursodeoxycholic effect in primary biliary cirrhosis. Liver 22: 235-244
(2002).
Molina P, Diehl AM, Guidot A, McClain C, Valla DC, Lang C, Neuman MG: Molecular
Pathology and Clinical Aspects of Alcohol-Induced Tissue Injury. Alcoholism: Clin Exp Res 26:
120-128 (2002).
Neuman MG, Benhamou JP, Ibrahim A, Malkiewicz IM, Spircu T, Martinot-Peignoux M, Shear
NH, Katz GG, Akremi R, Bourliere M, Marcellin P: Role of cytokines in the assessment of the
PCL Publications (2002) – Page 12
severity of chronic hepatitis C and the prediction of response to therapy. Rom J Gastroenterol.
11: 97-103 (2002).
Neuman MG: Synergetic signaling for apoptosis in vitro by ethanol and acetaminophen.
Alcohol. 27: 89-98 (2002).
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