蕭璦莉
(Ai-Li Shiau, Ph.D.)
台南市大學路 1 號, 成大醫學院；電話：(06) 2353535 ext. 5629；
傳真：(06) 2082705
電子郵件:
alshiau@mail.ncku.edu.tw
現職年月：特聘教授兼所長 (2015/08)
小檔案
學
歷
 英國愛丁堡大學分子生物學研究所博士 (1989-1993)
 台灣大學微生物學研究所碩士 (1978-1980)
 台灣大學公共衛生學系學士 (1973-1977)
經
歷
 成功大學微免所所長 (2015-迄今)
 成功大學微免所特聘教授 (2007-迄今)
 倫敦帝國學院血液科 (Department of Haematology, Division of
Investigative Science) 訪問研究員 (2007-2008)
 成功大學微免所教授 (2002-迄今)
 成功大學臨床醫學研究所合聘教授 (2002-迄今)
 成功大學微免所副教授 (1994-2002)
 成功大學醫學院微生物學科講師 (1986-1994)
 成功大學醫學院微生物學科助教 (1983-1986)
專長學門
 基因與細胞治療
 分子病毒學
 疫苗學
研究興趣
 轉譯醫學
 病毒致病機轉與治療新策略之研究
 自體免疫疾病致病機轉及治療之研究
1
PUBLICATION
Refereed papers
Publication Search http://www.ncbi.nlm.nih.gov/pubmed?term=shiau%20al
1.
Lu CS, Shieh GS, Wang CT, Su BH, Su YC, Chen YC, Su WC, Wu P, Yang
WH, Shiau AL*, Wu CL. Chemotherapeutics-induced Oct4 expression
contributes to drug resistance and tumor recurrence in bladder cancer.
Oncotarget 2016 May 26. doi: 10.18632/oncotarget.9602. [Epub ahead of print]
2. Peng JS, Chen SY, Wu CL, Chong HE, Ding YC, Shiau AL*, Wang CR.
Amelioration of experimental autoimmune arthritis through targeting synovial
fibroblasts by the intra-articular delivery of microRNA-140-3p and -5p. Arthritis
Rheumatol. 2016; 68: 370-81.
3. Su BH, Tseng YL, Shieh GS, Chen YC, Wu P, Shiau AL*, Wu CL.
Overexpression of prothymosin α antagonizes TGF-β signalling to promote the
development of emphysema. J. Pathol. 2016; 238: 412-22.
4. Su BH, Shieh GS, Tseng YL, Shiau AL*, Wu CL. Etoposide enhances antitumor
efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the
MDR1 promoter activity. Oncotarget 2015; 6: 38308-26.
5. Su YC, Ou HY, Wu HT, Wu P, Chen YC, Su BH, Shiau AL*, Chang CJ, Wu CL.
Prothymosin α overexpression contributes to the development of insulin
resistance. J Clin. Endocrinol. Metab. 2015; 100: 4114-23.
6. Chen SY, Shiau AL, Wu CL, Wang CR. Amelioration of experimental arthritis
by intra-articular injection of an epidermal growth factor receptor tyrosine kinase
inhibitor. Clin. Exp. Rheumatol. 2015; 33: 839-43.
7. Leu CH, Yang ML, Chung NH, Huang YJ, Su YC, Chen YC, Lin CC, Shieh GS,
Chang MY, Wang SW, Chang Y, Chao J, Chao L, Wu CL, Shiau AL*.
Kallistatin ameliorates influenza virus pathogenesis by inhibition of
kallikrein-related peptidase mediated cleavage of viral hemagglutinin.
Antimicrob. Agents Chemother. 2015;59: 5619-30.
8. Lee PH, Liu CM, Ho TS, Tsai YC, Lin CC, Wang YF, Chen YL, Yu CK, Wang
SM, Liu CC, Shiau AL, Lei HY, Chang CP. Enterovirus 71 virion-associated
galectin-1 facilitates viral replication and stability. PLoS One 2015;
10:e0116278.
9. Lu CS, Hsieh JL, Lin CY, Tsai HW, Su BH, Shieh GS, Su YC, Lee CH, Chang
MY, Wu CL, Shiau AL*. Potent antitumor activity of Oct4 and hypoxia
dual-regulated oncolytic adenovirus against bladder cancer. Gene Ther. 2015;
22:305-15.
10. Chen SY, Shiau AL, Li YT, Lin CC, Jou IM, Liu MF, Wu CL, Wang CR.
Transcription factor snail regulates tumor necrosis factor α-mediated synovial
fibroblast activation in the rheumatoid joint. Arthritis Rheumatol. 2015;
67:39-50.
11. Chen YF, Wang SH, Chang SJ, Shiau AL, Her LS, Shieh GS, Chen CF, Chang
CC, Su YC, Wu CL, Wu TS. Zhankuic acid A as a novel JAK2 inhibitor for the
treatment of concanavalin A-induced hepatitis. Biochem. Pharmacol. 2014;
91:217-30.
12. Shiau AL, Shen YT, Hsieh JL, Wu CL, Lee CH. Scutellaria barbata inhibits
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angiogenesis through downregulation of HIF-1 α in lung tumor. Environ.
Toxicol. 2014; 29: 363-70.
Chang MY, Yang YS, Tsai ML, Lee CH, Chang CJ, Shiau AL*, Wu CL.
Adenovirus-mediated prothymosin α gene transfer inhibits the development of
atherosclerosis in ApoE-deficient mice. Int. J. Biol. Sci. 2014; 10:358-66.
Chen YF, Shiau AL, Wang SH, Yang JS, Chang SJ, Wu CL, Wu TS. Zhankuic
acid A isolated from Taiwanofungus camphoratus is a novel selective
TLR4/MD-2 antagonist with anti-inflammatory properties. J. Immunol. 2014;
192:2778-86.
Jou YC, Tsai YS, Hsieh HY, Chen SY, Tsai HT, Chen KJ, Wang ST, Shiau AL,
Wu CL, Tzai TS. Plasma thymosin-α1 level as a potential biomarker in urothelial
and renal cell carcinoma. Urol. Oncol. 2013; 31:1806-11.
Hsieh JL, Shiau AL, Lee CH, Yang SJ, Lee BO, Jou IM, Wu CL, Chen SH, Shen
PC. CD8+ T cell-induced expression of tissue inhibitor of metalloproteinses-1
exacerbated osteoarthritis. Int. J. Mol. Sci. 2013; 14:19951-70.
Shen PC, Lu CS, Shiau AL, Lee CH, Jou IM, Hsieh JL. Lentiviral small hairpin
RNA knockdown of macrophage inflammatory protein-1γ ameliorates
experimentally induced osteoarthritis in mice. Hum. Gene Ther. 2013; 24:
871-82.
Tsai YS, Chen YH, Cheng PC, Tsai HT, Shiau AL*, Tzai TS, Wu CL. TGF-beta
1 conjugated to gold nanoparticles results in protein conformational changes and
attenuates the biological function. Small 2013; 9:2119-28.
Su BH, Tseng YL, Shieh GS, Chen YC, Shiang YC, Wu P, Li KJ, Yen TH,
Shiau AL*, Wu CL. Prothymosin α overexpression contributes to the
development of pulmonary emphysema. Nat. Commun. 2013; 4:1906. doi:
10.1038/ncomms2906.
Li YT, Chen SY, Wang CR, Liu MF, Lin CC, Jou IM, Shiau AL*, Wu CL.
Amelioration of collagen-induced arthritis in mice by lentivirus-mediated
silencing of microRNA-223. Arthritis Rheum. 2012; 64: 3240-5.
Chen KR, Chang CH, Huang CY, Lin CY, Lin WY, Lo YC, Yang CY, Hsing
EW, Chen LF, Shih SR, Shiau AL, Lei HY, Tan TH, Ling P. TBK1-associated
protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like
receptors to antiviral immunity. J. Biol. Chem. 2012; 287:32216-21.
Hsieh JL, Lu CS, Huang CL, Shieh GS, Su BH, Su YC, Lee CH, Chang MY,
Wu CL, Shiau AL*. Acquisition of an enhanced aggressive phenotype in human
lung cancer cells selected by suboptimal doses of cisplatin following cell
deattachment and reattachment. Cancer Lett. 2012; 321:36-44.
Chen SY, Shiau AL, Li YT, Lin YS, Lee CH, Wu CL, Wang CR. Suppression of
collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of
Toll-like receptor 7 short hairpin RNA gene. Gene Ther. 2012; 19:752-60.
Lee BF, Lee CH, Chiu NT, Hsia CC, Shen LH, Shiau AL*. Hypoxia imaging
predicts success of hypoxia-induced cytosine deaminase/5-fluorocytosine gene
therapy in a murine lung tumor model. Cancer Gene Ther. 2012; 19:255-62.
Huang YJ, Shiau AL*, Chen SY, Chen YL, Wang CR, Tsai CY, Chang MY, Li
YT, Leu CH, Wu CL. Multivalent structure of galectin-1-nanogold complex
serves as potential therapeutics for rheumatoid arthritis by enhancing receptor
clustering. Eur. Cell Mate. 2012; 23:170-81.
Feng YH, Wu CL, Shiau AL, Lee JC, Chang JG, Lu PJ, Tung CL, Feng LY,
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Huang WT, Tsao CJ. MicroRNA-21-mediated regulation of Sprouty2 protein
expression enhances the cytotoxic effect of 5-fluorouracil and metformin in
colon cancer cells. Int. J. Mol. Med. 2012; 29:920-26.
Lee CH, Hsieh JL, Wu CL, Hsu HC, Shiau AL*. B cells are required for
tumor-targeting Salmonella in host. App. Microbiol. Biotechnol. 2011;
92:1251-60.
Lin YY, Liao JD, Ju YH, Chang CW, Shiau AL. Focused ion beamfabricated Au
micro/nanostructures used as a surface enhanced Raman scattering-active
substrate for trace detection of molecules and influenza virus. Nanotechnology
2011; 22:185308.
Yang ML, Chen YH, Wang SW, Huang YJ, Leu CH, Yeh NC, Chu CY, Lin CC,
Shieh GS, Chen YL, Wang JR, Wang CH, Wu CL, Shiau AL*. Galectin-1 binds
to influenza virus and ameliorates influenza virus pathogenesis. J. Virol. 2011;
85: 10010-20.
Lee CH, Hsieh JL, Wu CL, Hsu PY, Shiau AL*. T cell augments the antitumor
activity of tumor-targeting Salmonella. Appl. Microbiol. Biotechnol. 2011;
90:1381-8.
Chang CH, Lai LC, Cheng HC, Chen KR, Syue YZ, Lu HC, Lin WY, Chen SH,
Huang HS, Shiau AL, Lei HY, Qin J, Ling P. TBK1-associated protein in
endolysosomes (TAPE) is an innate immune regulator modulating the TLR3 and
TLR4 signaling pathways. J. Biol. Chem. 2011; 286:7043-51.
Shen PC, Shiau AL, Jou IM, Lee CH, Tai MH, Juan HY, Lin PR, Liu GS, Wu
CL, Hsieh JL. Inhibition of cartilage damage by proopiomelanocortin
prohormone overexpression in a rat model of osteoarthritis. Exp. Biol. Med. 2011;
236:334-40.
Chen SY, Wu CL, Lai MD, Lin CC, Yo YT, Jou IM, Lee CH, Weng CT, Shiau
AL*, Wang CR. Amelioration of rat collagen-induced arthritis through CD4+ T
cells apoptosis and synovial interleukin-17 reduction by indoleamine
2,3-dioxygenase gene therapy. Hum. Gene Ther. 2011; 22:145-54.
Feng YH, Wu CL, Tsao CJ, Chang JG, Lu PJ, Yeh KT, Uen YH, Lee JC, Shiau
AL*. Deregulated expression of sprouty2 and microRNA-21 in human colon
cancer: Correlation with the clinical stage of the disease. Cancer Biol. Ther.
2011; 11:111-21.
Hsieh JL, Shen PC, Shiau AL, Jou IM, Lee CH, Wang CR, Teo ML, Wu CL.
Intraarticular gene transfer of thrombospondin-1 suppresses the disease
progression of experimental osteoarthritis. J. Orthop. Res. 2010; 28:1300-6.
Wang CR, Shiau AL, Chen SY, Cheng ZS, Li YT, Lee CH, Yo YT, Lo CW, Lin
YS, Juan HY, Chen YL, Wu CL. Intra-articular lentivirus-mediated delivery of
galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis.
Gene Ther. 2010; 17:1225-33.
Feng YH, Tsao CJ, Wu CL, Chang JG, Lu PJ, Yeh KT, Shieh GS, Shiau AL*,
Lee JC. Sprouty2 protein enhances the response to gefitinib through epidermal
growth factor receptor in colon cancer cells. Cancer Sci. 2010; 101:2033-8.
Shiau AL, Teo ML, Chen SY, Wang CR, Hsieh JL, Chang MY, Chang CJ, Chao
J, Chao L, Wu CL, Lee CH. Inhibition of experimental lung metastasis by
systemic lentiviral delivery of kallistatin. BMC Cancer 2010; 31:245-54.
Lee CH, Wu CL, Shiau AL*. Toll-like receptor 4 signaling promotes tumor
growth. J. Immunother. 2010; 33:73-82.
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40. Tsai YS, Shiau AL, Chen YF, Tsai HT, Tzai TS, Wu CL. Enhancement of
antitumor activity of gammaretrovirus carrying IL-12 gene through genetic
modification of envelope targeting HER2 receptor: a promising strategy for
bladder cancer therapy. Cancer Gene Ther. 2010; 17:37-48.
41. Chen SY, Shiau AL, Shieh GS, Su CH, Lee CH, Lee HL, Wang CR, Wu CL.
Amelioration of experimental arthritis by telomerase-dependent conditionally
replicating adenovirus that targets synovial fibroblasts. Arthritis Rheum. 2009;
60:3290-302.
42. Jou YC, Tung CL, Tsai YS, Shen CH, Syue-Yi C, Shiau AL, Tsai HT, Wu CL,
Tzai TS. Prognostic relevance of prothymosin-alpha expression in human upper
urinary tract transitional cell carcinoma. Urology 2009; 74:951-7.
43. Su WC, Liu WL, Cheng CW, Chou YB, Hung KH, Huang WH, Wu CL, Li YT,
Shiau AL, Lai MY. Ribavirin enhances interferon signaling via stimulation of
mTOR and p53 activities. FEBS Lett. 2009; 583:2793-8.
44. Yo YT, Shieh GS, Hsu KF, Wu CL, Shiau AL*. Licorice and licochalcone-A
induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2
expression and the mTOR pathway. J. Agric. Food Chem. 2009; 57:8266-73.
45. Tsai YS, Shiau AL*, Chen YF, Tsai HT, Lee HL, Tzai TS, Wu CL.
Enhancement of antitumor immune response by targeted interleukin-12
electrogene transfer through antiHER2 single-chain antibody in a murine bladder
tumor model. Vaccine 2009; 27:5383-92.
46. Hsu KF, Wu CL, Huang SC, Wu CM, Hsiao JR, Yo YT, Chen YH, Shiau AL*,
Chou CY. Cathepsin L mediates resveratrol-induced autophagy and apoptotic
cell death in cervical cancer cells. Autophagy 2009; 5:451-60.
47. Lee CH, Wu CL, Chen SH, Shiau AL*. Humoral immune responses inhibit the
antitumor activities mediated by Salmonella enterica serovar choleraesuis. J.
Immunother. 2009; 32:376-88.
48. Hsieh JL, Lee CH, Teo ML, Lin YJ, Huang YS, Wu CL, Shiau AL*.
Transthyretin-driven oncolytic adenovirus suppresses tumor growth in orthotopic
and ascites models of hepatocellular carcinoma. Cancer Sci. 2009; 100:537-45.
49. Wu MH, Hong TM, Cheng HW, Pan SH, Liang YR, Hong HC, Chiang WF,
Wong TY, Shieh DB, Shiau AL, Jin YT, Chen YL. Galectin-1-mediated tumor
invasion and metastasis, up-regulated matrix metalloproteinase expression, and
reorganized actin cytoskeletons. Mol. Cancer Res. 2009; 7:311-8.
50. Hsieh JL, Shen PC, Shiau AL, Jou IM, Lee CH, Teo ML, Wang CR, Chao J,
Chao L, Wu CL. Adenovirus-mediated kallistatin gene transfer ameliorates
disease progression in a rat model of osteoarthritis induced by anterior cruciate
ligament transection. Hum. Gene Ther. 2009; 20:147-58.
51. Tsai YS, Jou YC, Lee GF, Chen YC, Shiau AL, Tsai HT, Wu CL, Tzai TS.
Aberrant prothymosin-alpha expression in human bladder cancer. Urology 2009;
73:188-92.
52. Chang CC, Shieh GS, Wu P, Lin CC, Shiau AL*, Wu CL. Oct-3/4 expression
reflects tumor progression and regulates motility of bladder cancer cells. Cancer
Res. 2008; 68:6281-91.
53. Wang CR, Shiau AL*, Chen SY, Lin LL, Tai MH, Shieh GS, Lin PR, Yo YT,
Lee CH, Kuo SM, Liu MF, Jou IM, Yang CY, Shen PC, Lee HL, Wu CL.
Amelioration of collagen-induced arthritis in rats by adenovirus-mediated PTEN
gene transfer. Arthritis Rheum. 2008; 58:1650-6.
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54. Hsu KF, Wu CL, Huang SC, Hsieh JL, Huang YS, Chen YF, Shen MR, Chung
WJ, Chou CY, Shiau AL*. Conditionally replicating E1B-deleted adenovirus
driven by thesquamous cell carcinoma antigen 2 promoter for uterine cervical
cancer therapy. Cancer Gene Ther. 2008; 15:526-34.
55. Chang MY, Shiau AL, Chen YH, Chang CJ, Chen HH, Wu CL. Increased
apoptotic potential and dose-enhancing effect of gold nanoparticles in
combination with single-dose clinical electron beams on tumor-bearing mice.
Cancer Sci. 2008; 99:1479-84.
56. Lee CH, Wu CL, Shiau AL*. Toll-like receptor 4 mediates an antitumor host
response induced by Salmonella choleraesuis. Clin. Cancer Res. 2008;
14:1905-12.
57. Wu CL, Shieh GS, Chang CC, Yo YT, Su CH, Chang MY, Huang YH, Wu P,
Shiau AL*. Tumor-selective replication of an oncolytic adenovirus carrying
oct-3/4 response elements in murine metastatic bladder cancer models. Clin.
Cancer Res. 2008; 14:1228-38.
58. Hsu M, Wu SY, Chang SS, Su IJ, Tsai CH, Lai SJ, Shiau AL, Takada K, Chang
Y. Epstein-Barr virus lytic transactivator Zta enhances chemotactic activity
through induction of interleukin-8 in nasopharyngeal carcinoma cells. J. Virol.
2008; 82:3679-88.
59. Lee CH, Wu CL, Shiau AL*. Salmonella choleraesuis as an anticancer agent in a
syngeneic model of orthotopic hepatocellular carcinoma. Int. J Cancer. 2008;
122:930-5.
60. Wang CR, Chen SY, Shiau AL, Wu CL, Jou IM, Chao L, Chao J. Upregulation
of kallistatin expression in rheumatoid joints. J. Rheumatol. 2007; 34:2171-6.
61. Chu CY, Wang SY, Chen ZW, Chien MS, Huang JP, Chen JJ, Hong LS, Shiau
AL*, Tsai JL, Wu CL. Heterologous protection in pigs induced by a
plasmid-cured and crp gene-deleted Salmonella choleraesuis live vaccine.
Vaccine 2007; 25:7031-40.
62. Chen YH, Tsai CY, Huang PY, Chang MY, Cheng PC, Chou CH, Chen DH,
Wang CR, Shiau AL*, Wu CL. Methotrexate conjugated to gold nanoparticles
inhibits tumor growth in a syngeneic lung tumor model. Mol. Pharm. 2007;
4:713-22.
63. Yo YT, Hsu KF, Shieh GS, Lo CW, Chang CC, Wu CL, Shiau AL*.
Coexpression of Flt3 ligand and GM-CSF genes modulates immune responses
induced by HER2/neu DNA vaccine. Cancer Gene Ther. 2007; 14:904-17.
64. Shiau AL, Chen SY, Chang MY, Su CH, Chung SY, Yo YT, Wang CR, Wu CL.
Prothymosin α lacking the nuclear localization signal as an effective gene
therapeutic strategy in collagen-induced arthritis. J. Immunol. 2007;
178:4688-94.
65. Hsu KF, Huang SC, Shiau AL, Cheng YM, Shen MR, Chen YF, Lin CY, Lee
BH, Chou CY. Increased expression level of squamous cell carcinoma antigen 2
and 1 ratio is associated with poor prognosis in early-stage uterine cervical
cancer. Int. J Gynecol. Cancer 2007; 17:174-81.
66. Tsai CY, Shiau AL, Chen SY, Chen YH, Cheng PC, Chang MY, Chen DH,
Chou CH, Wang CR, Wu CL. Amelioration of collagen-induced arthritis in rats
by nanogold. Arthritis Rheum. 2007; 56:544-54.
67. Lee CH, Wu CL, Shiau AL*. Hypoxia-induced cytosine deaminase gene
expression for cancer therapy. Hum Gene Ther. 2007; 18:27-38.
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68. Shiau AL, Lin YP, Shieh GS, Su CH, Wu WL, Tsai YS, Cheng CW, Lai MD,
Wu CL. Development of a conditionally replicating pseudorabies virus for
HER-2/neu-overexpressing bladder cancer therapy. Mol. Ther. 2007; 15:131-8.
69. Chen YC, Chang MY, Shiau AL, Yo YT, Wu CL. Mitochondrial ribosomal
protein S36 delays cell cycle progression in association with p53 modification
and p21(WAF1/CIP1) expression. J. Cell Biochem. 2007; 100:981-90.
70. Shieh GS, Shiau AL, Yo YT, Lin PR, Chang CC, Tzai TS, Wu CL. Low-dose
etoposide enhances telomerase-dependent adenovirus-mediated cytosine
deaminase gene therapy through augmentation of adenoviral infection and
transgene expression in a syngeneic bladder tumor model. Cancer Res. 2006;
66:9957-66.
71. Chen SH, Yao HW, Huang WY, Hsu KS, Lei HY, Shiau AL, Chen SH. Efficient
reactivation of latent herpes simplex virus from mouse central nervous system
tissues. J. Virol. 2006; 80:12387-92.
72. Tzai TS, Tsai YS, Shiau AL, Wu CL, Shieh GS, Tsai HT. Urine prothymosin-α
as novel tumor marker for detection and follow-up of bladder cancer. Urology
2006; 67:294-9.
73. Shiau AL, Chen CC, Yo YT, Chu CY, Wang SY, Wu CL. Enhancement of
humoral and cellular immune responses by an oral Salmonella choleraesuis
vaccine expressing porcine prothymosin alpha. Vaccine 2005; 23:5563-71.
74. Huang TJ, Lu CC, Tsai JC, Yao WJ, Lu X, Lai MD, Liu HS, Shiau AL. Novel
autoregulatory function of hepatitis B virus M protein on surface gene expression.
J. Biol. Chem. 2005; 280:27742-54.
75. Lee CH, Wu CL, Tai YS, Shiau AL*. Systemic administration of attenuated
Salmonella choleraesuis in combination with cisplatin for cancer therapy. Mol.
Ther. 2005; 11:707-16.
76. Li KJ, Shiau AL, Chiou YY, Yo YT, Wu CL. Transgenic overexpression of
prothymosin alpha induces development of polycystic kidney disease. Kidney Int.
2005; 67:1710-22.
77. Jou IM, Shiau AL, Chen SY, Wang CR, Shieh DB, Tsai CS, Wu CL.
Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced
arthritis. Arthritis Rheum. 2005; 52:339-44.
78. Lin CF, Chiu SC, Hsiao YL, Wan SW, Lei HY, Shiau AL, Liu HS, Yeh TM,
Chen SH, Liu CC, Lin YS. Expression of cytokine, chemokine, and adhesion
molecules during endothelial cell activation induced by antibodies against
dengue virus nonstructural protein 1. J. Immunol. 2005; 174:395-403.
79. Shiau AL, Liu PS, Wu CL. Novel strategy for generation and titration of
recombinant adeno-associated virus vectors. J. Virol. 2005; 79:193-201.
80. Lee CH, Wu CL, Shiau AL*. Endostatin gene therapy delivered by Salmonella
choleraesuis in murine tumor models. J. Gene Med. 2004; 6:1382-93.
81. Lee CH, Wu CL, Shiau AL*. Systemic administration of attenuated Salmonella
choleraesuis carrying thrombospondin-1 gene leads to tumor-specific transgene
expression, delayed tumor growth and prolonged survival in the murine
melanoma model. Cancer Gene Ther. 2005; 12:175-84.
82. Lin CC, Chou CW, Shiau AL, Tu CF, Ko TM, Chen YL, Yang BC, Tao MH,
Lai MD. Therapeutic HER2/Neu DNA vaccine inhibits mouse tumor naturally
overexpressing endogenous neu. Mol. Ther. 2004; 10:290-301.
83. Hsiao JR, Jin YT, Tsai ST, Shiau AL, Wu CL, Su WC. Constitutive activation of
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STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and
correlates with better prognosis. Br. J. Cancer 2003; 89:344-9.
Hsieh JL, Wu CL, Lai MD, Lee CH, Tsai CS, Shiau AL*. Gene therapy for
bladder cancer using E1B-55 kD-deleted adenovirus in combination with
adenoviral vector encoding plasminogen kringles 1-5. Br. J Cancer 2003;
88:1492-9.
Hsieh JL, Wu CL, Lee CH, Shiau AL*. Hepatitis B virus X protein sensitizes
hepatocellular carcinoma cells to cytolysis induced by E1B-deleted adenovirus
through the disruption of p53 function. Clin. Cancer Res. 2003; 9:338-45.
Lin CF, Lei HY, Shiau AL, Liu CC, Liu HS, Yeh TM, Chen SH, Lin YS.
Antibodies from dengue patient sera cross-react with endothelial cells and induce
damage. J. Med. Virol. 2003; 69:82-90.
Lin CF, Lei HY, Shiau AL, Liu HS, Yeh TM, Chen SH, Liu CC, Chiu SC, Lin
YS. Endothelial cell apoptosis induced by antibodies against dengue virus
nonstructural protein 1 via production of nitric oxide. J. Immunol. 2002;
169:657-64.
Shiau AL, Liu CW, Wang SY, Tsai CY, Wu CL. A simple selection system for
construction of recombinant gD-negative pseudorabies virus as a vaccine vector.
Vaccine 2002; 20:1186-95.
Shiau AL, Lin PR, Chang MY, Wu CL. Retrovirus-mediated transfer of
prothymosin gene inhibits tumor growth and prolongs survival in murine bladder
cancer. Gene Ther. 2001; 8:1609-17.
Shiau AL, Chen YL, Liao CY, Huang YS, Wu CL. Prothymosin α enhances
protective immune responses induced by oral DNA vaccination against
pseudorabies delivered by Salmonella choleraesuis. Vaccine 2001; 19:3947-56.
Shiau AL, Chu CY, Su WC, Wu CL. Vaccination with the glycoprotein D gene
of pseudorabies virus delivered by nonpathogenic Escherichia coli elicits
protective immune responses. Vaccine 2001; 19:3277-84.
Shiau AL, Lin CY, Tzai TS, Wu CL. Postoperative immuno-gene therapy of
murine bladder tumor by in vivo administration of retroviruses expressing mouse
interferon-gamma. Cancer Gene Ther. 2001; 8:73-81.
Fan YF, Lu CC, Chen WC, Yao WJ, Wang HC, Chang TT, Lei HY, Shiau AL,
Su IJ. Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in
serum and liver at different replicative stages of chronic HBV infection.
Hepatology 2001; 33:277-86.
Tzai TS, Shiau AL, Liu LL, Wu CL. Immunization with TGF-β antisense
oligonucleotide-modified autologous tumor vaccine enhances the antitumor
immunity of MBT-2 tumor-bearing mice through upregulation of MHC class I
and Fas expressions. Anticancer Res. 2000; 20:1557-62.
Tzai TS, Shiau AL, Wu CL, Tsai YS. Postoperative administration of
interleukin-12 significantly enhances the anti-tumor immune response of MBT-2
bladder cancer bearing mice. Proc. Nat.l Sci. Counc. Repub. China B. 2000;
24:56-62.
Wu CL, Wu P, Shiau AL. A computerized management system for cell bank.
Anal. Biochem. 1999; 275:260-2.
Murray K, Shiau AL. The core antigen of hepatitis B virus as a carrier for
immunogenic peptides. Biol. Chem. 1999; 380:277-83.
Shiau AL, Yang HM, Wu P, Wu CL. Provision of positive and negative
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selections in retroviral vectors containing the cytosine deaminase gene. Gene
Ther. 1998; 5:1571-4.
99. Wu CL, Leu TS, Chang TT, Shiau AL*. Hepatitis C virus core protein fused to
hepatitis B virus core antigen for serological diagnosis of both hepatitis C and
hepatitis B infections by ELISA. J. Med. Virol. 1999; 57:104-10.
100. Tzai TS, Shiau AL, Wu CL, Chow NH, Tsai YS. Modulating the antitumor
immunity of MBT-2 murine bladder tumor bearing mice by postoperative
administration of interferon-alpha. Anticancer Res. 1998; 18:3355-61.
101. Tzai TS, Lin CI, Shiau AL, Wu CL. Antisense oligonucleotide specific for
transforming growth factor-β1 inhibit both in vitro and in vivo growth of MBT-2
murine bladder cancer. Anticancer Res. 1998; 18:1585-9.
102. Shiau AL, Wu CL. The inhibitory effect of Staphylococcus epidermidis slime on
the phagocytosis of murine peritoneal macrophages is interferon-independent.
Microbiol. Immunol. 1998; 42:33-40.
103. Shiau AL, Murray K. Mutated epitopes of hepatitis B surface antigen fused to
the core antigen of the virus induce antibodies that react with the native surface
antigen. J. Med. Virol. 1997; 51:159-66.
104. Tzai TS, Shiau AL, Lin CS, Wu CL, Lin JS. Modulation of the
immunostimulating effect of autologous tumor vaccine by anti-TGF-β antibody
and interferon-α on murine MBT-2 bladder cancer. Anticancer Res. 1997;
17:1073-8.
105. Wu CL, Shiau AL, Lin CS. Prothymosin α promotes cell proliferation in
NIH3T3 cells. Life Sci. 1997; 61:2091-101.
106. Shiau AL, Wu CL, Huang KY. The effect of thymosin on experimental herpes
simplex virus infections. J. Formosan Med. Assoc. 1988; 87:34-42.
Book chapters
1.
Wang CR, Shiau AL, Wu CL. Utility of animal models in research of
immunological and rheumatological disorders and identification of potential
therapeutics. In: Taiwan Rheumatology Textbook 2nd ed, 2011. Edited by
Rheumatology Society of ROC.
2.
Wang CR, Shiau AL, Wu CL. Targeting MIP-1α and its receptor CCR5 in rodent
models of rheumatoid arthritis. In: Chemokines Research Trends, 2007. Edited
by Grinwald LR, Hauppauge, Nova Publishers, New York. ISBN:
1-60021-588-2
蕭璦莉、蔡朝淵、李哲欣，奈米科技-基礎、應用與實作
第八章 生物奈
米世界，高立圖書有限公司，2005年2月，209-233。
3.
Patent
1. 吳文鑾、楊玫琳、蕭璦莉、吳昭良。2011。干擾素誘導之表現雙股ＲＮＡ之
核酸分子。中華民國專利證書：發明第 I 347362 號。
2. 吳昭良、蕭璦莉、蔡朝淵。2012。用以抑制血管內皮細胞生長因子作用之醫
藥組合物。中華民國專利證書：發明第 I369209 號。
English
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