1.Name: Dr. N.K. Lokanath
2.Designation: Professor
3. Qualification: M.Sc. Ph.D.
4. Area of Specialization: Protein Crystallography hairman/Member of Authority/Committee etc:
Sl.
No.
Chairman/Member/Secretary
1 Member
Committee/Authority
BOS in Microbiology
Year (From-To)
-2008
Articles in Journal:
1.
High-throughput crystallization-to-structure pipeline at RIKEN SPring-8 Center:
Sugahara M, Asada Y, Shimizu K, Yamamoto H, Lokanath NK , Mizutani H,
Bagautdinov B, Matsuura Y, Taketa M, Kageyama Y, Ono N, Morikawa Y, Tanaka Y,
Shimada H, Nakamoto T, Sugahara M, Yamamoto M, Kunishima N. J Struct Funct
Genomics . 9 (2008) 21-28.
2.
Crystallization and preliminary X-ray diffraction studies of SDiA from Escherechia coli :
Wu CA, Lokanath NK , Kim DY, Nguyen LD, Kim KK. Acta Crystallogr F Biol
Crystallogr ., 64 (2008) 19-21.
3.
Crystal structures of NTPase from Pyrococcus horikoshii OT3 and its complexes: recognition of dinucleotide binding sites: Lokanath NK , Pampa KJ, Takio K, Kunishima
N. J. Mol. Biol. 375 (2008) 1013-1025.
4.
Purification, crystallization and preliminary X-ray diffraction studies of a putative UDP-
N -acetyl-D-mannosamine dehydrogenase from Pyrococcus horikoshii OT3: Lokanath
NK , Pampa, KJ, Kamiya, T, Kunishima N. Acta Crystallogr F Biol Crystallogr ., 63
(2007) 412-414.
5.
Dimeric core structure of modular stator subunit E of archaeal H
+
-ATPase. Lokanath
NK , Matsuura Y, Kuroishi C, Takahashi N, Kunishima N. J. Mol Biol . 366 (2007) 933-
944.
6.
Purification, crystallization and preliminary X-ray crystallographic analysis of the archaeal phosphoglycerate mutase PH0037 from Pyrococcus horikoshii OT3: Lokanath
NK , Kunishima N. Acta Crystallogr F Biol Crystallogr ., 62 (2006) 788-790.
7.
Crystal structures of native and xylosaccharide-bound alkali thermostable xylanase from an alkalophilic Bacillus sp . NG-27: structural insights into alkalophilicity and implications for adaptation to polyextreme conditions: Manikandan K, Bhardwaj A,

Gupta N, Lokanath NK , Ghosh A, Reddy VS, Ramakumar S. Protein Sci . 2006 15,
1951-1960.
8.
Purification, crystallization and initial X-ray crystallographic analysis of the putative
GTPase PH0525 from Pyrococcus horikoshii OT3: Lokanath NK , Yamamoto H,
Matsunaga E, Sugahara M, Kunishima N. Acta Crystallogr F Biol Crystallogr ., 61 (2005)
892-894.
9.
Structure of inorganic pyrophosphatase from Helicobacter pylori : Wu CA, Lokanath
NK , Kim D, Park HJ, Hwang HJ, Kim ST, Suh SW, Kim KK. Acta Crystallogr D Biol
Crystallogr ., D61 (2005), 1459-1464.
10.
Crystal structure of Novel NADP-dependent 3-hydroxyisobutyrate dehydrogenase from Thermus thermophilus HB8: Lokanath NK , Shiromizu I, Nodake Y, Sugahara, M,
Yokoyama S, Kuramitsu S, Miyano, M, Kunishima N. J. Mol Biol . 352 (2005) 905-917.
11.
The target of RNAIII-activating protein (TRAP) from Staphylococcus aureus : purification, crystallization and preliminary X-ray analysis: Han YH, Kim YG, Kim DY,
Ha, SC, Lokanath NK , Kim KK . Biochim Biophys Acta . 1748(1) 2005 134-136.
12.
Purification, crystallization and preliminary crystallographic analysis of the vacuole-type
ATPase subunit E from Pyrococcus horikoshii OT3: Lokanath NK , Ukita Y, Sugahara
Y, Kunishima N Acta Crystallogr F Biol Crystallogr ., 61 (2005) 56-58.
13.
Crystal structure of Glycine Cleavage System: T-protein from Pyrococcus horikoshii OT3 at 1.5 Å resolution: Lokanath NK , Kuroishi C, Okazaki N, Kunishima
N. Proteins 58 (2004) 769-773.
14.
A poxvirus protein forms a complex with left-handed Z-DNA: crystal structure of a
Yatapoxvirus Zα bound to DNA: Ha SC, Lokanath NK , Van Quyen D, Wu CA,
Lowenhaupt K, Rich A, Kim YG, Kim KK. Proc. Natl. Acad. Sci. U S A . 101 (2004)
14367-14372.
15.
Crystal structure of alodolase from Thermus thermophilus HB8 showing contribution of oligomeric state to thermostability: Lokanath NK , Shiromizu I, Ohshima N, Nodake Y,
Sugahara, M, Yokoyama S, Kuramitsu S, Miyano M, Kunishima N. Acta Crystallogr D
Biol Crystallogr ., 60 (2004) 1816-1823.
16.
Purification, crystallization and preliminary crystallographic analysis of the glycinecleavage system component T-protein from Pyrococcus horikoshii OT3: Lokanath NK ,
Kuroishi C, Okazaki N, Kunishima N Acta Crystallogr D Biol Crystallogr ., 60 (2004)
1450-1452.
17.
Crystallization and preliminary X-ray crystallographic studies of NADP-dependent 3hydroxyisobutyrate dehydrogenase from Thermus thermophilus HB8: Lokanath NK ,
Shiromizu I, Nodake Y, Sugahara, M, Yokoyama S, Kuramitsu S, Miyano M, Kunishima
N. Acta Crystallogr D Biol Crystallogr ., 59 (2003) 2294-2296.
18.
Crystal structure of the protease domain of a heat-shock protein HtrA from Thermotoga maritima : Kim DY, Kim DR, Ha SC, Lokanath NK , Lee CJ, Hwang HY, Kim KK. J
Biol Chem ., 278 (2003) 6543-6551.
19.
Structural studies on C-2 substitution in a new set of synthetic aminodideoxy sugars: the steric bulk at C-2 influences the puckering of the pyranose ring: Suresh CG, Ravindran B,
Pathak T, Rao K, Shashidhara Prasad J, Lokanath NK.
Carbohydr Res ., 337 (2002)
1507-1512.

20.
Cloning, purification, crystallization and preliminary X-ray studies of RFC boxes II-VIII of replication factor C from Methanococcus jannaschii : Lee I, Lokanath NK , Min K, Ha
SC, Kim DY, Kim KK, Acta Crystallogr D Biol Crystallogr ., 58 (2002) 519-521. *
21.
Photoreduction of benzophenone analogues by alcohol and ether self recognition and molecualr assemblies: Mallesha H, Dinesha ND, Rangappa KS, Shashikanth
S, Lokanath NK , Sridhar MA, Shashidhara Prasad J, Ind. J. Chem ., 41B (2002) 196-200.
22.
Crystal structure of bis(diphenylphosphino)ethane bis(2selenopyridinato)platinum(II). Lokanath NK , Devarajegowda HC, Sridhar MA,
Shashidhara Prasad J, Narayan S, Jain VK. Anal Sci ., 17 (2001) 565-566.
23.
Crystal structure of diphenyl pyraline tetrachloroferrate: Lokanath NK , Sridhar MA,
Shashidhara Prasad J, Ramappa PG. Anal Sci., 17 (2001) 1135-1136.
24.
Crystal structure of a cholesterol based dimesogen: Sridhar MA, Lokanath NK ,
Shashidhara Prasad J, Yelammagad CV, Varshney SK, Liq. Cryst ., 28 (2001) 45-49.
25.
Synthesis and crystal structure of 1,3-dimethyl benzotriazolium trifluoromethane sulfonate: Rangappa KS, Mallesha H, Anil Kumar NV, Lokanath NK , Sridhar MA,
Shashidhara Prasad J, Mol. Cryst. Liq. Cryst ., 357 (2001) 291-298.
26.
Crystal structure of undecyloxybenzoic acid: Lokanath NK , Revannasiddaiah D, Sridhar
MA, Shashidhara Prasad J, Mol. Cryst. Liq. Cryst ., 357 (2001) 299-304.
27.
Crystal and molecular structure of 3,5,6-trichloro-2-pyridinol complexes: Sridhar
MA, Lokanath NK , Shashidhara Prasad J, Akmal Pasha, Mol. Cryst. Liq. Cryst ., 369
(2001) 153-165.
28.
Crystal structure of 4-n-Nonylbenzoic acid: Lokanath NK , Revannasiddaiah D, Sridhar
MA and Shashidhara Prasad J, Liq. Cryst ., 27 (2000) 767-774.
29.
Crystal structure of octyloxybenzoic acid: Lokanath NK , Revannasiddaiah D, Sridhar
MA and Shashidhara Prasad J, Mol. Cryst. Liq. Cryst ., 348 (2000) 7-13.
30.
Synthesis and structural characterization of Na
2
MnP
2
O
7
crystal: Lokanath NK , Sridhar
MA, Shashidhara Prasad J, Gopalakrishna GS, Ashamanjari KG, J. Mat. Sci. Letts ., 23
(2000) 175-178.
31.
Structural studies of some phenoxazine derivatives: Sridhar MA, Ramegowda
M, Lokanath NK , Shashidhara Prasad J, Ere Gowda GB, Thimmaiah, KN, Mol.Cryst.
Liq. cryst ., 312 (1999) 189-214.
32.
Silicagel support mediated nonphotolytic cleavage of the rhenium-rhenium bond of
[{NC
5
H
4
N = NC
6
H
4
(R)}(CO)
3
Re0]
2
. Synthesis of the monomeric species Re1{NC
5
H
4
N
= NC
6
H
4
(R)}(CO)
3
Cl, crystal structure, spectroscopic and electron-transfer properties:
Samanta R, Munshi P, Santra B.K, Lokanath NK , Sridhar M.A, Shashidhara Prasad J,
Lahiri GK, J.
Organometllic Chem ., 579 (1999) 311-320.
33.
Synthesis and structural characterization of (Na
2
CoP
2
O
7
)
2
crystal: Lokanath NK , Sridhar
MA, Shashidhara Prasad J, Gopalakrishna GS, Ashamanjari KG, J. Mat. Sci. Letts ., 18
(1999) 1723-1726.
34.
Structure of 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorodecyl 1,10-ditosylate by X-ray crystallography and 19F-NMR spectroscopy: Soma De, Lokanath NK , Sridhar MA,
Shashidhara Prasad J, Venkatesan K, Bhattacharya S, J. Mol. Str ., 479 (1999) 75-81. *
35.
Crystal and molecular structure of dibromamine-T: Yathirajan HS, Rangappa KS,
Nagendra P, Mohana KN, Sridhar MA, Lokanath NK , Shashidhara Prasad J, Ind. J.
Chem ., 38A (1999) 1169-1172.

36.
Crystal structure of di-(2,7-disubstituted-9 fluorenyl) glutamate: Surendranath
V, Lokanath NK , Sridhar MA, Shashidhara Prasad J, Liq. Cryst ., 24 (1998) 361-368.
37.
Crystal structure of (2,4-dichlorophenoxy)acetohydrazide: Lokanath NK , Sridhar MA,
Shashidhara Prasad J, Nagaraja HS, Mohan Rao P, Acta Crystallogr ., C54 (1998) 669-
670.
38.
Syntheses, structure, reactivity and species recognition studies of oxo-vanadium(V) and molybdenum(VI) complexes: Rao CP, Sreedhara A, Rao PV, Bindu Verghese M,
Rissanen K, Kolehmainen E, Lokanath NK , Sridhar MA, Shashidhara Prasad J, J.
Chem. Soc ., Dalton Trans. (1998) 2383-2393.
39.
Crystal structure of two triazoles: Sridhar MA, Lokanath NK , Shashidhara Prasad J,
Rangappa KS, Anil Kumar NV, Bhadre Gowda DG, Mol. Cryst. Liq. Cryst ., 319 (1998)
137-146.
40.
Crystal and molecular structure studies of some organic haloamines: Lokanath NK ,
Sridhar MA, Shashidhara Prasad J, Yathirajan HS, Mohana KN, Rangappa KS, Mol.
Cryst. Liq. Cryst ., 319 (1998) 271-290.
41.
Recognition of oxovanadium(V) species and its separation from other metal species through selective complexation by some acyclic ligands: Rao CP, Sreedhara A,
Venkateswara Rao P, Lokanath NK , Sridhar MA, Shashidhara Prasad J, Kari
Rissanen, Polyhedron , 18 (1998) 289-297.
42.
Crystal structure of octyl benzoic acid: Lokanath NK , Krishne Gowda D,
Revannasiddaiah D, Abdoh MMM, Sridhar MA, Shashidhara Prasad J, Mol. Cryst. Liq.
Cryst ., 312 (1998) 153-164.
43.
Crystal structure of 4-(4'-chlorophenyl)-2,6-dimethyl-3,5-dimethoxy carbonyl-1,4dihydro pyrridine: Lokanath NK , Sridhar MA, Shashidhara Prasad J, Maitreya Joshi,
Dharmendra A Thaker, Anamik Shah, Z. Kristallogr ., 212 (1997) 13-14.
44.
Crystal structure of 3-(6H-dibenzo[b,e]thiepin-11-ylidene) propyl-dimethyl amine hydrochloride-cobalt chloride complex: Lokanath NK , Sridhar MA, Shashidhara Prasad
J, Bhojya Naik HS, Ramappa PG, Z. Kristallogr ., 212 (1997) 15-16.
45.
Crystal structure of metaclopromide-manganese chloride complex: Lokanath NK ,
Sridhar MA, Shashidhara Prasad J, Z. Kristallogr ., 212 (1997) 19-20.
46.
Crystal structure of 10-(3'-N-morpholinopropyl)-2-trifluoro phenoxazine hydrochloride: Lokanath NK , Sridhar MA, Shashidhara Prasad J, Rame Gowda M,
Eregowda GB, Thimmaiah KN, Z. Kristallogr ., 212 (1997) 21-22.
47.
Crystal structure of 10-(3'-chloropropyl)-2-chlorophenoxazine: Rame Gowda
M, Lokanath NK , Sridhar MA, Shashidhara Prasad J, Eregowda GB, Thimmaiah KN, Z.
Kristallogr ., 212 (1997) 23-24.
48.
Crystal structure of 10-(N-piperdino acetyl)-2-trifluromethyl phenoxazine: Lokanath
NK , Rame Gowda M, Sridhar MA, Shashidhara Prasad J, Eregowda GB, Thimmaiah
KN, Z. Kristallogr ., 212 (1997) 25-26.
49.
Crystal structure of 10-(3'-N-morpholinopropyl)-2-trifluoro methyl phenoxazine: Rame
Gowda M, Lokanath NK , Sridhar MA, Shashidhara Prasad J, Eregowda GB, Thimmaiah
KN, Z. Kristallogr ., 212 (1997) 27-28.
50.
Crystal structure of N-[O-anisole] anthranilic acid: Lokanath NK , Sridhar MA,
Shashidhara Prasad J, Bhadre Gowda DG, Rangappa KS, Z. Kristallogr ., 212 (1997) 29.
51.
Crystal structure of 1-benzyl-1,2,3-triazole: Sridhar MA, Lokanath NK , Shashidhara
Prasad J, Bhadre Gowda DG, Rangappa KS, Z. Kristallogr ., 212 (1997) 30.

52.
Crystal structure of 1-(anilino)-1(-phenyl methylino)penta carbonyl chromium: Lokanath NK , Sridhar MA, Shashidhara Prasad J, Manjunatha Swamy,
Rangappa KS, Z. Kristallogr ., 212 (1997) 31-32.
53.
Crystal structure of 1-methyl-3-phenyl-1,2,3-triazolinium perchlorate: Sridhar
MA, Lokanath NK , Shashidhara Prasad J, Bhadre Gowda DG, Rangappa KS, Z.
Kristallogr ., 212 (1997) 33-34.
54.
Crystal structure of N-p-methoxybenzylidene p-phenylazoaniline: Revannasiddaiah
D, Lokanath NK , Krishne Gowda D, Sridhar MA, Shashidhara Prasad J, Z. Kristallogr .,
212 (1997) 387-388.
55.
Crystal structure of 4-cyanophenyl 4-heptylbenzoate: Lokanath NK , Revannasiddaiah
D, Krishne Gowda D, Sridhar MA, Shashidhara Prasad J, Z. Kristallogr ., 212 (1997) 385-
386.
56.
Crystal structure of 1-benzyl-4-phenyl-1,2,3-triazole: Lokanath NK , Sridhar MA,
Shashidhara Prasad J, Bhadre Gowda DG, Rangappa K.S, Z. Kristallogr ., 212 (1997) 35-
36.
57.
Crystal structure of 4-isothiocyanatophenyl 4-pentylbicyclo [2,2,2] octane-1-carboxylate:
Sridhar MA, Lokanath NK , Revannasiddaiah D, Shashidhara Prasad J, Mol. Cryst.
Liq .
Cryst ., 299 (1997) 509-515.
Papers in Conference / Conference/Seminar participated:
(1)First crystal structure of the 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase: Lokanath NK,
Nakamura M, Ohshima N, Takio, K, Kunishima N. Fifth East Asian Biophysics Symposium &
Forty-Fourth Annual Meeting of the Biophysical Society of Japan (EABS & BSJ), 12-16
November, 2006, Okinawa, Japan.
(2)Crystal structure of modular stator subunit E of archaeal ATPase from pyrococcus horikoshii
OT3: Lokanath NK, Kuroishi C, Sugahara M, Kunishima N. Amercan Crystallographic
Association (ACA), 22-27 July, 2006 Honolulu, Hawaii, USA.
(3)The fourth international workshop on X-ray damage to biological crystalline samples, 7-8
March, 2006, SPring-8, Japan.
(4)Crystal Structure of Novel NADP-dependent 3-hydroxyisobutyrate dehydrogenase from
Thermus thermophilus HB8: Lokanath NK, Ohshima N, Takio K, Shiromizu I, Kuroishi C,
Okazaki N, Kuramitsu S, Yokoyama S, Miyano M, Kunishima N. XX Congress of the
International Union of Crstallography (IUCr), 23-31 August, 2005 Firenze, Italy.
(5)Crystal structure of Glycine Cleavage System: T-protein from Pyrococcus horikoshii OT3 at
1.5 Å resolution: Lokanath NK, Kuroishi C, Okazaki N, Kunishima N The Third International
Conference on Structural Genomics, 17-21 November, 2004 Washington DC, USA.
(6)Crystal structure of Malate dehydrogeanse from Pyrococcus horikoshii OT3 revealed a new type of NADP folding: Lokanath NK, Fujimoto Y, Kumei M, Kunishima N. The Eighth
Conference on Biology and Synchrotron Radiation, 7-11 September, 2004, Himeji, Japan.
(7)Annual Meeting of Structural-Biological Whole Cell Project of Thermus thermophilus HB8,
30 July - 1st August, 2004, SPring-8, Japan.
(8)Crystal structure of NADP-dependent 3-hydroxyisobutyrate dehydrogenase from Thermus thermophilus HB8: Lokanath NK, Ohshima N, Uchida Y, Shiromizu I, Sugahara, M, Kunishima

N. Second International Symposium "Current Trends in Drug Discovery & Research", 17-20
February, 2004, CDRI, Lucknow, India.
-glucosidase at atomic resolution  (9)Structure of and complex with glucose: Lokanath NK,
Shiromizu I, Matsunaga E, Tanaka T, Kunishima N. The First Pacific-Rim International
Conference on Protein Science, 14-18 April, 2004, Pacifico Yokohama, Japan.
(10)RIKEN/BBSRC Symposium of Japan-UK Protein Structural Biology, 11-12 September,
2003, SPring-8, Japan.
(11)Annual Meeting of Structural-Biological Whole Cell Project of Thermus thermophilus HB8,
1-3 August, 2003, SPring-8, Japan.
(12)Crystal structure of alodolase from Thermus thermophilus HB8 showing contribution of oligomeric state to thermostability: Lokanath NK, Shiromizu I, Matsunaga E, Tanaka T,
Kunishima N. International symposium on Diffraction Structural Biology, 28th May-2nd June,
2003, Tsukuba, Japan.
(13)The Eighth Harima International Forum of Structural Biology of Biological Machinary, 19-
20 March, 2003, SPring-8, Japan.
(14)Structure of NADP-dependent 3-hydroxyisobutyrate dehydrogenase: Lokanath NK and
Kunishima N. Annual Meeting of Structural-Biological Whole Cell Project of Thermus thermophilus HB8, 26-27 July, 2002, SPring-8, Japan.
(15)Structure of ribosome recycling factor with different ligands: Lokanath NK, Jin-hee Joeng,
Chunai-Wu, Kyeong Kyu Kim. The Fourth Asian Crystallography Association, 18-21
November, 2001, Bangalore, India.