Iar
db_HP_01
Institute for Animal Reproduction
db mouse（C57BLKS/J Iar -+Leprdb /+Leprdb ）
Model animal for non-insulin-dependent
diabetes mellitus
db/db, male,
8-week-old
Origin
db mouse, C57BLKS/J Iar -+Leprdb/+Leprdb,
is introduced to the Institute for Animal
Reproduction from Hamamatsu University
School of Medicine in 1985.
Coat color
db/db (homo) and m+/db (hetero): Black
m+/m+ (misty): Gray
m+/db, male,
8-week-old
Characteristics
This strain is a NIDDM, non-insulin-dependent
diabetes mellitus, model animal that shows similar
symptoms of human’s obesity diabetes.
This shows overeating and obesity caused by
abnormality of the leptin receptor.
m+/m+, male,
8-week-old
Homo mouse indicates increases of weight and blood
glucose level after three to four weeks of its birth.
Genetic symbol, Leprdb, is added since causational
gene is abnormality of the leptin receptor.
Growth chart (db/db, male)
Blood glucose level in mg/dL (db/db, male)
Body weight in grams w/S.D.
45.0
40.0
35.0
30.0
25.0
20.0
15.0
10.0
n=39
Diet: Autoclaved MF
5.0
Blood glucose level in mg/dL w/S.D.
50.0
0.0
4
5
6
7
8
9
10
11
12
n=39
Diet: Autoclaved MF
4
Age in weeks
Data has been taken since
June 2014.
650.0
600.0
550.0
500.0
450.0
400.0
350.0
300.0
250.0
200.0
150.0
100.0
50.0
0.0
6
8
10
12
Age in weeks
Institute for Animal Reproduction
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http://www.iar.or.jp/english/index.html
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Fast: non
Observation: between 10 am and 11 am
Measurement instrument: Blood glucose test meter GT-1641 ARKRAY,
Inc.
Blood collection: facial vein
Limit value: 600 mg/dL (When the value exceeds 600 mg/dL, it indicates
600 mg/dL)