James M. Murphy
1
05/09
CURRICULUM VITAE
James M. Murphy
Associate Dean for Research and Graduate Education
Dean’s Office, LD222
School of Science, IUPUI
and
Professor of Psychology
Department of Psychology, LD124
Psychobiology Program
School of Science, IUPUI
402 North Blackford Street
Indianapolis, IN 46202-3275
Phone: (317) 274-6762
Fax: (317) 274-6756
e-mail: jmurphy1@iupui.edu
and
Institute of Psychiatric Research, PR103
Indiana University School of Medicine, IUPUI
791 Union Drive
Indianapolis, IN 46202-4887
Phone: (317) 278-0910
Fax: (317) 274-1365
James M. Murphy
2
TABLE OF CONTENTS
Page
Appointments and Employment History.………………………………………………………..…..
3
Education and Degrees……………………………………………………………………………….
4
Teaching Experience........................................................................................……………
4
Graduate Program Student Committees.............................................................……………….
5-6
Postdoctoral Supervision..................................................................................………………….
6
Service Committees and Standing Positions........................................................………………
7
Professional Society Memberships and Services.................................................………………
8
Honors, Fellowships and Awards......................................................................…………………
9
Grants Funded and Completed ..........................................................................……………….
10-11
Current Grants …………………………………………..........................................………………
11
Full-Length Publications and Book Chapters.......................................................………………
12-20
Manuscripts In Press..........................................................................................…………………
21
Manuscripts Submitted for Publication or Under Revision......................................…………….
21
Published Abstracts and Presentations at National and International Meetings........………….
22-38
James M. Murphy
Appointments and Employment History
2008-present
Associate Dean for Research and Graduate Education
School of Science,
Indiana University Purdue University at Indianapolis
1994-present
Professor of Psychology
Department of Psychology, Purdue School of Science
Indiana University Purdue University at Indianapolis
1985-present
Faculty, Program in Medical Neuroscience
Indiana University School of Medicine, Indianapolis
1989-1994
Associate Professor of Psychology
Department of Psychology, Purdue School of Science
Indiana University-Purdue University at Indianapolis
1985-1989
Assistant Professor (part-time)
Department of Psychology, Purdue School of Science
Indiana University Purdue University at Indianapolis
1985-1989
Assistant Scientist of Neurobiology
Medical Neurobiology Program
Indiana University School of Medicine, Indianapolis
1982-1985
Instructor (part-time)
Department of Psychology, Purdue School of Science
Indiana University Purdue University at Indianapolis
1979-1985
Research Associate in Psychiatry
Institute of Psychiatric Research, Department of Psychiatry
Indiana University School of Medicine, Indianapolis
1977-1979
Visiting Assistant Professor
Department of Psychology
University of Virginia, Charlottesville, VA
3
James M. Murphy
4
Education and Degrees
B.A. (1971) Psychology, Edinboro University of Pennsylvania. Senior research paper: Failure to find
operant escape from non-contingent positive brain stimulation in rats.
M.A. (1974) Experimental Psychology, Bowling Green State University, OH. Masters Thesis Title: Rate of
central nervous system maturation and the development of long-term memory in neonatal mice.
Ph.D. (1978) Experimental Psychology, concentration in Psychobiology, Bowling Green State University,
OH. Ph.D. Dissertation Title: The role of catecholamines in the mediation of starvation- and
amphetamine-induced locomotor arousal in mice.
Teaching Experience
Department of Psychology, Purdue School of Science,
Indiana University-Purdue University at Indianapolis
Laboratory courses
Introductory Laboratory in Psychology
Laboratory in Motivation
Laboratory in Learning
Laboratory in Physiological Psychology
Lecture courses
Undergraduate
Introductory Psychology as a Biological Science
Learning
Drugs and Behavior
Behavioral Neuroscience/Physiological Psychology
Graduate
Behavioral Neuroscience/Physiological Psychology
Psychobiology of Learning and Motivation
Drugs of Abuse and Addictive Behavior
Psychopharmacology
Mentor courses
Honors Independent Study
Honors Research
Readings and Research in Psychology
Medical Neuroscience Program and Department of Psychiatry
Indiana University School of Medicine
Neurobiology for Psychiatry Residents (lectures on
Neurochemistry, Neuroanatomy and Neurobiology of Alcoholism)
Methods in Cell and Neurobiology (lectures on HPLC Theory and Methodology)
Assisted in Supervision of several Medical Student Research Rotations
Institute of Psychiatric Research
James M. Murphy
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Graduate Program Student Committees
Carla Trusty-Smith, M.S. committee member; Differences in laboratory measures of biological
consequences in Type I and Type II alcoholism: Validating evidence for the Cloninger typology.
Department of Psychology, IUPUI. Awarded December 1990.
Lisa Ehrman, Ph.D. preliminary advisory committee member; Department of Psychology, IUPUI. 199
Eric A. Engleman, Ph.D. committee member; Serotonin receptor subtypes and brain regions associated
with operant response suppression in an animal model of depression. Program in Medical
Neurobiology, Indiana University School of Medicine, Awarded December 1992.
Gregory J. Gatto, Ph.D. committee member; Reward-relevant actions of alcohol in selectively bred lines
of rats. Program in Medical Neurobiology, Indiana University School of Medicine, Awarded December
1992.
Sue C. Spaulding, M.S. committee member; The effects of HIV infection on neuropsychological test
performance: A quantitative review. Department of Psychology, IUPUI, July, 1993.
Robert L. Hewitt, M.S. committee member; Tolerance development to the ethanol suppressant effects of
the benzodiazepine inverse agonist RO19-4603, in alcohol preferring (P) rats. Department of
Psychology, IUPUI, May, 1994.
Michael Gibbs, M.S. advisory committee member; Program in Medical Neurobiology, Indiana University
School of Medicine.
Robert Kohl, Ph.D. advisory committee member; Program in Medical Neurobiology, Indiana University
School of Medicine.
Carrie Jones, Ph.D. preliminary examination committee member; Program in Medical Neurobiology,
Indiana University School of Medicine.
Simon N. Katner, Ph.D. committee chair and advisory committee chair; Program in Medical
Neurobiology, Indiana University School of Medicine,1995.
Paul McKinley, M.S. committee member; M.S. Degree awarded posthumously, Psychobiology Program,
Department of Psychology, IUPUI, 1998.
Jeffrey Broome, M.S. committee member, Program in Medical Neurobiology, Indiana University School
of Medicine, Glial cell line-derived neurotrophic factor protects midbrain dopamine neurons from the
lethal action of the weaver gene: A quantitative immunocytochemical study. January 1999.
Stephanie Rock, Ph.D. committee co-chair; Psychobiology Program, Department of Psychology, IUPUI,
Ethanol and cocaine interactive effects on local cerebral glucose utilization (LCGU). April 1999.
Jason Katner, M.S. committee chair, Psychobiology Program, Department of Psychology, IUPUI,
completed.
Jennifer Learn, Ph.D. Preliminary and advisory committee and Ph.D. dissertation committee member;
Program in Medical Neurobiology, Indiana University School of Medicine, completed.
Robert Sahr, Ph.D. advisory committee member; Program in Medical Neurobiology, Indiana University
School of Medicine, completed.
Daniel G. Smith, Ph.D committee chair; Psychobiology Program, Department of Psychology, IUPUI,
completed, May 2002.
Roberto I. Melendez, Ph.D. preliminary advisory committee chair; Psychobiology Program, Department
of Psychology, IUPUI, completed.
Roberto I. Melendez, Ph.D. committee chair; Psychobiology Program, Department of Psychology,
IUPUI, Completed.
Eric Claus, M.S. thesis committee member; Program in Clinical Rehabilitation, Department of
Psychology, IUPUI, in progress.
Alexis Behm, M.S. thesis committee chair. Program in Psychobiology, Department of Psychology,
IUPUI, completed. Preliminary qualification committee chair, in progress.
Christine Fontinella, Ph.D. Preliminary and advisory committee, Program in Medical Neurobiology,
Indiana University School of Medicine.
Katrina Foster. Ph.D. preliminary qualification committee member and dissertation committee member;
Psychobiology Program, Department of Psychology, IUPUI, completed.
Nicholas Gilpin, Ph.D. committee chair; Program in Psychobiology, Department of Psychology, IUPUI,
completed. Preliminary qualification committee, completed. Ph.D. dissertation committee, completed
December 2005
Lathan Hardy, M.S. thesis committee member; Program in Psychobiology, Department of Psychology,
IUPUI, completed.
James M. Murphy
6
James E. Woods, II. Ph.D. preliminary examination advisory committee and dissertation committee
member; Psychobiology Program, Department of Psychology, IUPUI, Completed.
Kelly Knopp, Ph.D. Preliminary and advisory committee, Program in Medical Neuroscience, Indiana
University School of Medicine, Completed. Dissertation committee member,completed
Vanessa Barth. Ph.D. Program in Medical Neuroscience, Indiana University School of Medicine,
advisory committee, completed. Dissertation committee member,completed
Michelle Carroll, Ph.D. committee member; Program in Psychobiology, Department of Psychology,
IUPUI, completed; Preliminary examination advisory committee chair, completed. Dissertation
committee chair, in progress.
Amy Kostrzewa, Ph.D. advisory committee member, Program in Medical Neuroscience, Indiana
University School of Medicine, in progress. Preliminary qualification committee, completed.
Dissertation member, in progress.
Kelle Franklin, Ph.D. committee chair; Program in Psychobiology, Department of Psychology, IUPUI,
completed. Dissertation committee chair, in progress
Scott Oster, Ph.D. committee chair; Program in Psychobiology, Department of Psychology, IUPUI,
completed; Dissertation committee chair, in progress
Jamie Toalston, Ph.D. committee chair; Program in Psychobiology, Department of Psychology, IUPUI,
completed; Dissertation committee chair, in progress
Dennise Garzon, M.S. thesis committee member; Program in Psychobiology, Department of
Psychology, IUPUI, completed.
William Eiler, M.S. thesis committee member; Program in Psychobiology, Department of Psychology,
IUPUI, completed; Dissertation committee chair, in progress
Megan Bertholomy, M.S. thesis committee chair; Program in Psychobiology, Department of Psychology,
IUPUI, in progress
Heather Musselman, M.S. thesis committee member; Program in Psychobiology, Department of
Psychology, IUPUI, in progress
Alexis Green, M.S. thesis committee member; Program in Psychobiology, Department of Psychology,
IUPUI, completed; Preliminary examination advisory committee member, completed. Dissertation
committee member, in progress.
Angela Henderson, M.S. thesis committee member; Program in Psychobiology, Department of
Psychology, IUPUI, in progress
Postdoctoral Supervision
Previous
Dr. Andrew D. Levy, Postdoctoral NIAAA Training Fellow
Dr. Robert B. Stewart, Postdoctoral Research Associate in Medicine
Dr. Wanda Dyr, Visiting Polish Scientist
Dr. Jack K. Chamberlain, Postdoctoral NIAAA Training Fellow
Dr. David McKinzie, Postdoctoral NIAAA Training Fellow
Dr. Satoshi Ikemoto, Postdoctoral Research Associate in Psychiatry
Dr. Karen Nowak, Postdoctoral NIAAA Training Fellow
Dr. Karen Nowak, Research Associate in Psychiatry
Dr. Eric Engleman, Research Associate in Psychiatry
Dr. Ying Zhang, Research Associate in Psychology and Psychiatry
Dr. Nancy Badia-Elder, Assistant Scientist in Psychology
James M. Murphy
7
Service Committees and Standing Positions
Department of Psychology, School of Science, IUPUI
Ad Hoc Grant Merit Review Committee, Chair (Fall 2001-Spring 2002)
Ad Hoc Introductory Textbook Selection Committee, Chair (Fall 1989-Spring 1990)
Ad Hoc Psychology Chair Search and Screen Committee (Fall 1990-Spring 1991)
Ad Hoc Psychology Grant Merit Committee (Fall 2001-Spring 2002)
Animal Care Supervisor (Fall 1989-Summer 1998)
Chair=s Council (Summer 1995-Summer 1998)
Departmental Space Committee, Chair (Fall 1997-Summer 1998)
Director of Psychobiology of Addictions Program (Summer 1993-Summer1998;Fall 2001-Summer
2008)
Director of Graduate Studies (Summer 1992-Summer 1993)
Executive Committee (Fall 1989-Summer 1991; Fall 2004-present)
Faculty Evaluation Committee (Summer 1995-Summer 1998; Chair Summer 1996-Fall 1998)
Graduate Goals Committee (Fall 1994)
Promotion and Tenure Committee (Fall 1994-Summer 1998; Fall 2000-Fall 2002; Fall 2005-present)
Psychobiology Committee (Fall 1993-Present)
Search and Screen Committee for Experimental Psychobiology Program (Fall 1991-Spring 1993)
Undergraduate Committee (Fall 1989-Fall 1991)
School of Science, IUPUI
Animal Facility Budget Committee (Chair, Fall 2000-Spring 2005; Summer 2008-present)
Animal Facility Space Committee (Chair, Fall 2000- Spring 2005-present)
Center for Therapeutic Behavioral Neuroscience (Member, Board of directors, Spring 2003)
Department of Geology, Promotion and Tenure Committee (Fall 1996-Spring 2004)
Institutional Animal Care and Use Committee (member Fall 1989-Spring 2005; Chair, Summer 2000Spring 2005)
Nominations and Awards Committee (member Fall 1990-Spring 1994; Chair, Fall 2000-Spring 2001
and Fall 2006 – Spring 2007)
Promotion and Tenure Area Committee (Fall 1994-Spring 1999; Fall 2001-Spring 2002)
School of Science Research Committee (member Fall 2005-Summer 2008; Chair Summer 2008present)
School of Science and School of Engineering & Technology joint building committee chair; (Fall
2008-present)
Teaching Committee (Fall 1989-Spring 1990)
School of Medicine, IUPUI
School of Medicine, Laboratory Animal Resource Advisory Committee (Spring 1997-present)
Animal Laboratory Task Force (Fall 2003-Fall 2004)
Institute of Psychiatric Research and Medical Neurobiology Program, School of Medicine, IUPUI
Coordinator: Institute of Psychiatric Research In-House
Research Seminar Series (Fall 1988-Spring 1993)
Department of Psychiatry Mentor Committees (3 faculty; various dates)
University, IUPUI
Institutional Animal Care and Use Committee (Fall 1989-Fall 1992)
Budgetary Affairs Committee (Summer 1990-Summer 1994)
Faculty Board of Review (Spring 1990-Spring 1992)
Nominations Committee (Fall 1991-Summer 1993)
Tenure and Promotion Committee (Fall 1994-Spring 1995)
University Faculty Council (Fall 1991-Summer 1993)
Evaluation Committee, Dean of Science (Fall 1995-Spring 1996)
James M. Murphy
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Professional Society Memberships
American Association for the Advancement of Science (p
American Psychological Society
Indiana Chapter of Society for Neuroscience
International Brain Research Organization
International Society for Biomedical Research on Alcoholism
Midwestern Psychological Association
Research Society on Alcoholism
Sigma Xi
Society for Neuroscience
Professional Journal Referee Services
Alcohol
Alcohol & Alcoholism
Alcoholism: Clinical and Experimental Research
Behavioral Teratology and Toxicology
Brain Research
Brain Research Bulletin
Drug and Alcohol Dependence
Journal of Neurochemistry
Journal of Pharmacology and Experimental Therapeutics
Life Sciences
Molecular Therapy
Neuropsychopharmacology
Pharmacology Biochemistry and Behavior
Physiology and Behavior
Proceedings of the National Academy of Sciences USA
Professional Grant Review Services
National Science Foundation, Washington, D.C., Ad hoc reviewer
Veterans Administration Medical Center, Indianapolis, IN, Ad hoc reviewer
Medical Research Council of Canada, Ad hoc reviewer
NIH, National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel, March 7, 1997
NIH, National Institute on Alcohol Abuse and Alcoholism, Small Business Innovation Research Grants,
March 2, 1998
NIH, National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel, March 3, 1998
NIH, National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel, October 30, 1998
NIH, National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel, August 10, 1999
National Institute on Alcohol Abuse and Alcoholism, Small Business Innovation Research Grants,
January 13, 2000
NIH, National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel, April 24-26, 2000
Veterans Administration, Ad hoc merit review, 2000.
NIH, National Institute on Alcohol Abuse and Alcoholism, Small Business Innovation Research Grants,
November 1, 2000
NIH, National Institute on Alcohol Abuse and Alcoholism, Ad hoc reviews, November 8, 2004
NIH, National Institute on Alcohol Abuse and Alcoholism, Ad hoc reviews, Development Center P20
reviews, May 30, 2007
NIH, National Institute on Alcohol Abuse and Alcoholism, Ad hoc reviews, NAL study section reviews,
October 11, 2007
Other Professional Services
President of Indianapolis Chapter of Society for Neuroscience. Term: May 1993-May 1995
Elections Committee, Research Society on Alcoholism, Spring 2000-Spring 2002
James M. Murphy
Honors, Fellowships and Awards
Summa Cum Laude (B.A.)
University Fellowship, 1973-1974; 1975-1976
Teaching Fellowship, 1974-1975
Bowling Green State University Distinguished Dissertation Award, 1978
Faculty Research Award, School of Science, IUPUI, 1994
Service Award, School of Science, IUPUI, 2000
School of Science, IUPUI, Special Service Recognition, Fall 2005
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James M. Murphy
10
Grants Funded (Completed)
Li, T.-K., Lumeng, L., McBride, W.J., Waller, M.B., and Murphy, J.M. (Co-I). Biochemistry of alcohol
drinking behavior and alcoholism, PHS RO1 AA03243, National Institute on Alcohol Abuse and
Alcoholism; Funded 7/1/83-6/30/88.
Richter, J.A., Simon, J.R., McBride, W.J., Murphy, J.M., (Co-I), Nurnberger, J.I., Jr., and Shekhar, A.
Spectrophotometer for IPR. Indiana University School of Medicine Grant-in-Aid. 1985.
Li, T.-K., Lumeng, L., McBride, W.J., Murphy, J.M., (Co-I), Froehlich, J., and Morzorati, S. Biochemistry
of alcohol drinking behavior and alcoholism, PHS RO1 AA03243, National Institute on Alcohol Abuse
and Alcoholism; Funded 7/1/88-6/30/90.
Li, T.-K., McBride, W.J., Morzorati, S., Murphy, J.M., (Co-I), and Stewart, R.B. Basic studies on animal
models of alcoholism. Regenstrief Foundation, Indianapolis, IN. Annual competitive renewal funding
1985-1992; last funded period 7/1/91-6/30/92.
Lumeng, L. (PI), Murphy, J.M. (Preceptor). Training grant on genetic aspects of alcoholism. National
Institute on Alcohol Abuse and Alcoholism; Funded 7/1/90-6/30/00.
Murphy, J.M. (PI). Blood Platelet Serotonin in Alcohol-Preferring and -Nonpreferring Rats and the
Effects of Ethanol. Pilot Project: Center on Genetic Determinants of Alcohol Ingestion, (Center PI, Dr.
T.-K. Li), PHS P50 AA07611. National Institute on Alcohol Abuse and Alcoholism. Pilot Project:
9/1/88-11/30/90.
McBride, W.J., and Murphy, J.M., (Co-I). Preclinical testing of pharmacological agents for potential use
in the treatment of alcohol abuse. Lilly Research Laboratories, Funding approved 5/1/92-6/30/93.
Murphy, J.M., (PI), Stewart, R.B., and Brush, F.R. Behavior and behavioral pharmacology component of
program project: Neurobiology and genetics of alcohol-seeking behavior. (Program Project PI, Dr.
T.-K. Li), National Institute on Alcohol Abuse and Alcoholism; Funded 7/1/90-6/30/95.
McBride, W.J., and Murphy, J.M. Neurochemistry component of program project: Neurobiology and
genetics of alcohol-seeking behavior. (Program Project PI, Dr. T.-K. Li), National Institute on Alcohol
Abuse and Alcoholism; Funded 7/1/90-6/30/95.
Bosron, W.F., Dean, R.A., and Murphy, J.M., (Co-I). Enzymology and regulation of cocaine ester
metabolism. National Institute on Drug Abuse. Funded 8/1/92-7/30/95.
McBride, W.J., and Murphy, J.M., (Co-PI). CNS sites of rewarding actions of alcohol. National Institute
on Alcohol Abuse and Alcoholism; Funded 4/1/93-3/31/96.
Murphy, J.M., Zhou, F.C., and McKinzie, D.L. Influence of developmental environment on behavior of
selectively bred alcohol-preferring and -nonpreferring rats. Indiana Alcohol Research Pilot Project
Grant. Funded 7/1/94-11/30/95.
McBride, W.J., Murphy, J.M., (Co-I), Li, T.-K., Lumeng, L., and Ikemoto, S. Neural basis of the alcohol
deprivation effect. National Institute on Alcohol Abuse and Alcoholism; Funded 7/1/97-6/30/00,
Murphy, J.M., (PI), and Bowers, B. Innate stress reactivity and high alcohol preference. Pilot project
funded through the Indiana Alcohol Research Center. National Institute on Alcohol Abuse and
Alcoholism; Funded 12/1/98-11/30/00; $50,000 annual direct costs.
Murphy, J.M., (co-mentor), and McBride, W.J. National Research Service Award for Daniel G. Smith.
Local cerebral glucose utilization and alcohol relapse. National Institute on Alcohol Abuse and
Alcoholism; Funded 8/1/98-7/30/01; $21,800 annual direct costs
James M. Murphy
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Murphy, J.M., (component PI) Substrates of disinhibition and alcohol preference. Component of the
Indiana Alcohol Research Center. National Institute on Alcohol Abuse and Alcoholism; Funded
12/1/97-11/30/02; $108,000 annual direct costs
McBride, W.J., (PI) Murphy, J.M. (Co-I). CNS Sites for the Rewarding Actions of Alcohol. National
Institute of Alcohol Abuse and Alcoholism, Funded 04/01/00-03/31/05; $199,561 annual direct costs
Murphy, J.M., (PI), and Engleman, E.A. CNS sites mediating alcohol drinking behavior. National Institute
on Alcohol Abuse and Alcoholism; Funded 8/1/95-6/30/05; $175,000 annual direct costs
Stewart, R.B., Lumeng, L., Morzorati, S., Murphy, J.M. (Co-I), and Badia-Elder, N. Alcohol tolerance in
rat lines selected for preference. National Institute on Alcohol Abuse and Alcoholism; Funded
7/1/00-6/30/05 (in “no-cost” extension); $250,000 annual direct costs
McBride, W.J., Murphy, J.M., (Co-I), Li, T.-K., Lumeng, L., Thielen, R., and Rodd-Henricks. Neural basis
of the alcohol deprivation effect. National Institute on Alcohol Abuse and Alcoholism; Funded
4/1/01-3/31/06; $200,000 annual direct costs
Badia-Elder, N.E., Stewart, R.B., Li, T.-K., Murphy, J.M., (Co-I), and Engleman, E.A. Neuropeptide Y
and alcohol related behavior. National Institute on Alcohol Abuse and Alcoholism; Funded,
8/1/01-6/30/06; $175,000 annual direct costs
McBride W.J. (component PI) and Murphy, J.M. (Co-I) (component of Crabb, D.W.; PI, Indiana Alcohol
Research Center on Genetic Determinants of Alcohol Ingestion); component “Animal Genetics
Component.” National Institute on Alcohol Abuse and Alcoholism; Funded, 12/1/02-11/30/07;
$180,950 component annual direct costs
McBride, W.J., and Murphy, J.M., (Co-I). Neurobiological Factors in Adolescent Alcohol Drinking. NIH,
National Institute on Alcohol Abuse and Alcoholism; Funded 4/2001 - 04/12/05; $225,000 annual
direct costs
Grants Funded (Current)
Murphy, J.M. (PI) Activating effects of ethanol in selectively bred rats. NIH, National Institute on Alcohol
Abuse and Alcoholism; Funded 09/26/2005 - 06/30/2010; $140,000 average annual direct costs
Murphy, J.M., (PI), and Engleman, E.A. CNS sites mediating alcohol drinking behavior. NIH, National
Institute on Alcohol Abuse and Alcoholism; Funded 07/01/2007 - 06/30/2011; $191,250 annual direct
costs
McBride, W.J. (PI) (Murphy, J.M., serve as preceptor). Training grant on genetic aspects of alcoholism.
NIH, National Institute on Alcohol Abuse and Alcoholism; Funded 7/1/95-6/30/10.
James M. Murphy
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Full-Length Publications and Book Chapters
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Nagy, Z.M., and Murphy, J.M. (1974). Development of a short-term memory capacity for escape
training in neonatal C3H mice. Bulletin of the Psychonomic Society 3: 19-20.
Nagy, Z.M., and Murphy, J.M. (1974). Learning and retention of a discriminated escape response in
infant mice. Developmental Psychobiology 7: 185-192.
Nagy, Z.M., Murphy, J.M., and Ray, D. (1975). Development of behavioral arousal and inhibition in
the Swiss-Webster mouse. Bulletin of the Psychonomic Society 6: 146-148.
Murphy, J.M., and Nagy, Z.M. (1976). Neonatal hyperthyroidism alters the development of
behavioral arousal and inhibition in the mouse. Bulletin of the Psychonomic Society 8: 121-123.
Murphy, J.M., and Nagy, Z.M. (1976). Development of cholinergic inhibitory capacities in the
hyperthyroid mouse. Pharmacology Biochemistry & Behavior 5: 449-456.
Murphy, J.M., and Nagy, Z.M. (1976). Neonatal thyroxine stimulation accelerates the maturation of
both locomotor and memory processes in mice. Journal of Comparative and Physiological
Psychology 90: 1082-1091.
Nagy, Z.M., Murphy, J.M., and Ray, D. (1978). Relative aversion thresholds for shock in infant mice.
Developmental Psychobiology 11: 261-270.
Murphy, J.M., Meeker, R.B., Porada, K.J., and Nagy, Z.M. (1979). GABA-mediated behavioral
inhibition during ontogeny in the mouse. Psychopharmacology 64: 237-242.
Murphy, J.M., and Nagy, Z.M. (1979). Comparison of behavioral activity in two apparatus for food
deprived mice. Bulletin of the Psychonomic Society 14: 43-45.
Murphy, J.M., and Nagy, Z.M. (1979). FLA-63 blocks food-deprivation induced behavioral arousal in
the mouse. Physiological Psychology 7: 407-411.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1980). LCEC determination of monoamine
levels in nine brain regions of alcohol-preferring rats. Symposium on the Neurochemical and Clinical
Applications of LCEC 1: 63-64.
Gold, P.E., and Murphy, J.M. Brain noradrenergic responses to training and to amnestic frontal
cortex stimulation. (1980). Pharmacology Biochemistry & Behavior 13: 257-263.
Forster, M.J., Nagy, Z.M., and Murphy, J.M. (1981). Potentiation of amphetamine-induced
hyperactivity in the adult mouse following neonatal thyroxine administration. Bulletin of the
Psychonomic Society 18: 337-339.
Murphy, J.M., Flint, R.S., Calkins, P.M., Ciancone, M.T., and McBride, W.J. (1982). Application of
LCEC for the determination of the in vitro stimulated monoamine release from discrete regions of rat
brain. Symposium on the Biomedical Applications of LCEC and Voltammetry 3: No. 62.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1982). Regional brain levels of monoamines
in alcohol-preferring and -nonpreferring lines of rats. Pharmacology Biochemistry & Behavior 16:
145-149.
Gold, P.E., Murphy, J.M., and Cooley, S. (1982). Neuroendocrine modulation of memory during
development. Behavioral and Neural Biology 35: 277-293.
McBride, W.J., Flint, R.S., Ciancone, M.T., and Murphy, J.M. (1983). In vitro release of endogenous
monoamines and amino acids from several CNS regions of the rat. Neurochemical Research 8:
245-257.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1983). Monoamine and metabolite levels in
CNS regions of the P line of alcohol-preferring rats after acute and chronic ethanol treatment.
Pharmacology Biochemistry & Behavior 19: 849-856.
Flint, R.S., Murphy, J.M., and McBride, W.J. (1985). Release of endogenous dopamine,
3,4-dihydroxyphenylacetic acid and amino acid transmitters from rat striatal slices. Neurochemical
Research 10: 515-527.
Murphy, J.M., Cunningham, S.D., and McBride, W.J. (1985). Effects of 250 mg% ethanol on
monoamine and amino acid release from rat striatal slices. Brain Research Bulletin 14: 439-442.
Murphy, J.M., Waller, M.B., Gatto, G.J., McBride, W.J., Lumeng, L., and Li, T.-K. (1985).
Monoamine uptake inhibitors attenuate ethanol intake in alcohol-preferring (P) rats. Alcohol 2:
349-352.
Flint, R.S., Murphy, J.M., Calkins, P.M., and McBride, W.J. (1985). Monoamine, amino acid and
cholinergic interactions in slices of rat cerebral cortex. Brain Research Bulletin 15: 197-202.
James M. Murphy
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23. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1986). Effects of ethanol on monoamine
and amino acid release from cerebral cortical slices of the alcohol-preferring P-line of rats.
Alcoholism: Clinical and Experimental Research 10: 205-208.
24. Waller, M.B., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Effect of low dose
ethanol on spontaneous motor activity in alcohol-preferring and -nonpreferring rats. Pharmacology
Biochemistry & Behavior 24: 617-623.
25. Li, T.-K., Lumeng, L., McBride, W.J., Waller, M.B., and Murphy, J.M. (1986). Studies on an animal
model of alcoholism. In: Genetic and Biological Markers in Drug Abuse and Alcoholism, NIDA
Research Monograph No. 66, edited by M.C. Braude & H.M. Chao. Washington, DC, U.S.
Government Printing Office, 41-49.
26. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Alcohol preference and regional
brain monoamine contents of N/Nih heterogeneous stock rats. Alcohol and Drug Research 7: 33-37.
27. Murphy, J.M., Gatto, G.J., Waller, M.B., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Effects of
scheduled access on ethanol intake by the alcohol-preferring (P) line of rats. Alcohol 3: 331-336.
28. Li, T.-K., Lumeng, L., McBride, W.J., and Murphy, J.M. (1987). Rodent lines selected for factors
affecting alcohol consumption. Alcohol & Alcoholism Suppl. 1: 91-96.
29. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1987). Contents of monoamines in forebrain
regions of alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Pharmacology Biochemistry &
Behavior 26: 389-392.
30. Gatto, G.J., Murphy, J.M., Waller, M.B., McBride, W.J., Lumeng, L., and Li, T.-K. (1987). Chronic
ethanol tolerance through free-choice drinking in the P line of alcohol-preferring rats. Pharmacology
Biochemistry & Behavior 28: 111-115.
31. Gatto, G.J., Murphy, J.M., Waller, M.B., McBride, W.J., Lumeng, L., and Li, T.-K. (1987).
Persistence of tolerance to a single dose of ethanol in the selectively bred alcohol-preferring P rat.
Pharmacology Biochemistry & Behavior 28: 105-110.
32. Li, T-K., Lumeng, L., McBride, W.J., and Murphy, J.M. (1987). Alcoholism: Is it a model for the study
of disorders of mood and consummatory behavior? Annals of the New York Academy of Sciences
499: 239-249.
33. Lumeng, L., Murphy, J.M., McBride, W.J., and Li, T-K. (1987). Basic neurochemical mechanisms of
modulation of alcohol consumption in the P and NP rats. In: Pharmacology: Proceedings of the Xth
International Congress of Pharmacology, edited by M.J. Rand and C. Raper. New York: Elsevier,
727-730.
34. Khatib, S.A., Murphy, J.M., and McBride, W.J. (1988). Biochemical evidence for activation of
specific monoamine pathways by ethanol. Alcohol 5: 295-299.
35. Li, T.-K., Lumeng, L., Doolittle, D.P., McBride, W.J., Murphy, J.M., Froehlich, J.C., and Morzorati, S.
(1988). Behavioral and neurochemical associations of alcohol-seeking behavior. In: Biomedical and
Social Aspects of Alcohol and Alcoholism, edited by K. Kuriyama, A. Takada, and H. Ishii.
Amsterdam: Excerpta Medica, 435-438.
36. Li, T.-K., Lumeng, L., Froehlich, J.C., Murphy, J.M., and McBride, W.J. (1988). Genetic influence on
response to the reinforcing properties of ethanol in rats. In: Biomedical and Social Aspects of
Alcohol and Alcoholism, edited by K. Kuriyama, A. Takada, and H. Ishii. Amsterdam: Excerpta
Medica, 487-490.
37. Li, T.-K., Lumeng, L., McBride, W.J., Murphy, J.M., Froehlich, J.C., and Morzorati, S. (1988).
Pharmacology of alcohol preference in rodents. Advances in Alcohol & Substance Abuse 7: 73-86.
38. Lumeng, L., Murphy, J.M., McBride, W.J., and Li, T.-K. (1988). Behavioral and biochemical
correlates of alcohol drinking preference: Studies on the selectively bred P and NP rats. Australian
Alcohol and Drug Review 7: 17-20.
39. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1988). Effects of Ro 15-4513, fluoxetine and
desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and
-nonpreferring (NP) lines of rats. Pharmacology Biochemistry and Behavior 30: 1045-1050.
40. Murphy, J.M., McBride, W.J., Gatto, G.J., Lumeng, L., and Li, T.-K. (1988). Effects of acute ethanol
administration on monoamine and metabolite content in forebrain regions of ethanol- tolerant and
-nontolerant alcohol-preferring (P) rats. Pharmacol Biochem Behav 29: 169-174.
41. Murphy, J.M., Waller, M.B., Gatto, G.J., McBride, W.J., Lumeng, L., and Li, T.-K. (1988). Effects of
fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats.
Alcohol 5: 283-286.
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42. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989). Serotonin and ethanol preference. In:
Recent Developments in Alcoholism, Vol. 7, edited by M. Galanter. New York: Plenum, 187-209.
43. Gongwer, M.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1989). Regional brain
contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol
drinking lines of rats. Alcohol 6: 317-320, 1989.
44. Lumeng, L., Li, T.-K., McBride, W.J., Murphy, J.M., Morzorati, S., and Froehlich, J.C. (1989).
Mechanism(s) of modulation of alcohol consumption: Studies on the P and NP rats. In: Molecular
Mechanisms of Alcohol, edited by G.Y. Sun, Y.-H. Wei, P.K. Rudeen, W.G. Wood and A.Y. Sun.
Clifton, NJ: Humana Press, 359-370.
45. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989). Spiroxatrine augments the fluoxetine
induced reduction of ethanol intake by alcohol-preferring (P) rats. Pharmacology Biochemistry and
Behavior 34: 381-386.
46. Murphy, J.M., Gatto, G.J., McBride, W.J., Lumeng, L., and Li, T.-K. (1989). Operant responding for
oral ethanol in the alcohol-preferring P and alcohol-nonpreferring NP lines of rats. Alcohol 6:
127-131.
47. Wong, D.T., and Murphy, J.M. (1989). Serotonergic mechanisms in alcohol intake. In: Molecular
Mechanisms of Alcohol, edited by G.Y. Sun, Y.-H. Wei, P.K. Rudeen, W.G. Wood and A.Y. Sun.
Clifton, NJ: Humana Press, 133-146.
48. Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1990). Effects of fluoxetine and
desipramine on palatability-induced ethanol consumption in the alcohol-nonpreferring (NP) line of
rats. Alcohol 7: 531-536.
49. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1990). Serotonin, dopamine and GABA
involvement in alcohol drinking of selectively bred rats. Alcohol 7: 199-205. (Selected for Reprinting
in: Annual Review of Addictions Research and Treatment, 1992, 193-202.)
50. Murphy, J.M., Gatto, G.J., McBride, W.J., Lumeng, L., and Li, T.-K. (1990). Persistence of tolerance
in the P line of alcohol-preferring rats does not require performance while intoxicated. Alcohol 7:
367-369.
51. Engleman, E.A., Hingtgen, J.N., Zhou, F.C., Murphy, J.M., and Aprison, M.H. (1991). Potentiated
5-hydroxytryptophan response suppression following 5,7-dihydroxytyptamine raphe lesions in an
animal model of depression. Biological Psychiatry, 30: 317-320.
52. Levy, A.D., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1991). Microinjection of sulpiride
into the nucleus accumbens increases ethanol intake of alcohol-preferring (P) rats. Alcohol &
Alcoholism (Suppl. 1): 417-420.
53. McBride, W.J., Murphy, J.M., Gatto, G.J., Levy, A.D., Lumeng, L., and Li, T.-K. (1991). Serotonin
and dopamine systems regulating alcohol intake. Alcohol & Alcoholism (Suppl. 1): 411-416.
54. Stewart, R.B., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J. M. (1991). Chronic Alcohol
Consumption in alcohol-preferring P rats attenuates subsequent conditioned taste aversion
produced by ethanol injections. Psychopharmacology, 105: 530-534.
55. Zhou, F.C., Bledsoe, S., and Murphy, J. (1991). Serotonergic sprouting is induced by
dopamine-lesion in substantia nigra of adult rat brain. Brain Research, 556:108-116.
56. Engleman, E.A., Murphy, J.M., Zhou, F.C., and Hingtgen, J.N. (1992). Response suppression
induced with selective 5-HT agonists can be differentially blocked with LY53857 in an animal model
of depression. Neurochemical Research, 17: 483-488.
57. Engleman, E.A., Hingtgen, J.N., Zhou, F.C., Murphy, J.M., and Aprison, M.H. (1992). Evidence of
hypersensitive postsynaptic serotonin receptors in an animal model of depression. In R. Murison
(ed.), Endocrine and Nutritional Control of Basic Biological Function. Toronto: Holgrefe-Huber,
421-425.
58. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1992). Serotonin and alcohol consumption.
In: C.A. Naranjo and E.M. Sellers (eds.), Novel Pharmacological Interventions for Alcoholism. New
York: Springer-Verlag, pp. 59-67.
59. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1992). Serotonin and ethanol drinking in the
alcohol-preferring (P) rat. Clinical Neuropharmacology, 15 (Suppl. 1A): 301-302.
60. Dyr, W., McBride, W.J., Lumeng, L., Li, T.-K. and Murphy J.M. (1993). Effects of D1 and D2
dopamine receptor agents on ethanol consumption in the high alcohol drinking (HAD) line of rats.
Alcohol, 10: 207-212.
James M. Murphy
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61. Li, T.-K., Lumeng, L., McBride, W.J., and Murphy, J.M. (1993). An experimental approach to
understanding the genetic and neurobiological basis of alcoholism. Transactions of the American
Clinical and Climatological Association. 104: 61-73.
62. McBride, W.J., Murphy, J.M., Gatto, G.J., Levy, A.D., Yoshimoto, K., Lumeng, L., and Li, T.-K.
(1993). CNS mechanisms of alcohol self-administration. Alcohol & Alcoholism (Suppl. 2): 463-467.
63. McBride, W.J., Murphy, J.M., Yoshimoto, K., Lumeng, L., and Li, T.-K. (1993). Serotonin
mechanisms in alcohol drinking behavior. Drug Development Research, 30: 170-177.
64. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1993). Serotonin regulation of alcohol
drinking. In: P.M. Vanhoutte, P.R. Saxena, R. Paoletti, N. Brunello and A.S. Jackson (eds.), Second
International Symposium on Serotonin from Cell Biology to Pharmacology and Therapeutics. Milan,
Italy: Kluwer Academic Publishers, 375-381.
65. Stewart, R.B., Gatto, G.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1993). Comparison of
alcohol-preferring P and -nonpreferring NP rats on tests of anxiety and on the anxiolytic effects of
ethanol. Alcohol, 10: 1-10.
66. Gatto, G.J., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1994). Ethanol self-infusion into
the ventral tegmental area by alcohol-preferring rats. Alcohol 11: 557-564.
67. June, H.L., Murphy, J.M., Mellor-Burke, J.J. Lumeng, L., and Li, T.-K. (1994). The benzodiazepine
inverse agonist Ro19-4603 exerts prolonged and selective suppression of ethanol intake in
alcohol-preferring (P) rats. Psychopharmacology, 115: 325-331.
68. Li, T.-K., Lumeng, L., McBride, W.J. and Murphy, J.M. Genetic and neurobiological basis of alcoholseeking behavior. Alcohol Alcohol. 29:697-700, 1994.
69. Stewart, R.B., Russell, R.N., Lumeng, L., Li, T.-K., and Murphy, J.M. (1994). Consumption of sweet,
salty, sour and bitter solutions by selectively-bred alcohol preferring P and nonpreferring NP lines of
rats. Alcoholism: Clinical and Experimental Research, 18: 375-381.
70. Zhou, F.C., Pu, C.F., Murphy, J., Lumeng, L., and Li, T.-K. (1994). Serotonergic Neurons in the
alcohol preferring rats. Alcohol 11: 397-403.
71. Engleman, E.A., Murphy, J.M. Zhou, F.C., Aprison, M.H., and Hingtgen, J.N. (1995) Operant
response suppression induced with systemic administraton of 5-hydroxytryptophan is centrally
mediated. Pharmacology Biochemistry and Behavior 52: 525-529.
72. June, H.L., Lin, M., Greene, T.L., Lewis, M.J., and Murphy, J.M. (1995). Effects of negative
modulators of GABAergic efficacy on ethanol intake: Correlation of biochemical changes with
pharmacological effect using a behavioral paradigm. Experimental and Clinical
Psychopharmacology 3: 252-260.
73. June, H.L., Duemler, S.E., Greene, T.L., Williams, J.A., Lin, M., Devaraju, S.L., Chen, S.H.A.,
Lewis, M.J., and Murphy, J.M. (1995). Effects of the benzodiazepine inverse agonist RO19-4603 on
the maintenance of tolerance to a single dose of ethanol. Journal of Pharmacology and
Experimental Therapeutics 274: 1105-1112.
74. June, H.L., Murphy, J.M., Hewitt, R.L., Greene, T.L., Lin, M., Mellor-Burke, J.J., Lumeng, L., and Li,
T.-K. (1996). Benzodiazepine receptor ligands with different intrinsic efficacies alter ethanol intake in
alcohol-nonpreferring (NP) rats. Neuropsychopharmacology 14: 55-66.
75. Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J. (1995). Genetic influences on alcohol
preference in animals. In: H. Begleiter and B. Kissin (eds.), Genetics of Alcoholism, Vol 1. New
York: Oxford University Press, pp. 165-201.
76. Stewart, R.B., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1996). Place conditioning
with alcohol in alcohol-preferring P and -nonpreferring NP rats. Pharmacology Biochemistry and
Behavior 53: 487-491.
77. McKinzie, D.L., Eha, R., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1996). Effects of
taste aversion training on the acquisition of alcohol drinking in adolescent P and HAD rat lines.
Alcoholism: Clinical and Experimental Research 20: 682-687.
78. Katner, S.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1996). Effects of cholinergic
agents on locomotor activity of P and NP rats. Alcoholism: Clinical and Experimental Research 20:
1004-1010.
79. Russell, R.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1996). Apomorphine and 7OH DPAT reduce ethanol intake of P and HAD rats. Alcohol 13: 515-519.
James M. Murphy
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80. June, H.L., Greene, T.L., Murphy, J.M., Hite, M., Williams, J.A, Cason, C.R., Mellor-Burke, J.J., Cox,
R., Duemler, S.E., Torres, L., Lumeng, L., and Li, T.-K. (1996). Effects of the benzodiazepine
inverse agonist RO19-4603 alone, and in combination with the benzodiazepine receptor
antagonists, flumazenil, ZK 93426, and CGS 8216 on ethanol intake in alcohol-preferring (P) rats.
Brain Research 734: 19-34.
81. Ikemoto, S., Murphy, J.M., and McBride, W.J. (1997). Self-infusion of GABAA antagonists directly
into the ventral tegmental area and adjacent regions. Behavioral Neuroscience 111: 369-380.
82. Katner, S.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1997). Involvement of the
cholinergic system in alcohol drinking behavior. Addiction Biology 2: 215-223.
83. Katner, S.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1997). Alcohol intake of P rats
is regulated by muscarinic receptors in the pedunculopontine nucleus and VTA. Pharmacology
Biochemistry and Behavior 54: 497-504.
84. Godfrey, C.D., Stewart, R.B., Froehlich, J.C., Li, T.-K., and Murphy, J.M. (1997). Comparison of rats
selectively bred for high and low ethanol intake in a forced swim test model of depression: Effects of
desipamine. Physiology & Behavior 62: 729-733.
85. Ikemoto, S., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). 6-OHDA-lesions of the
nucleus accumbens disrupt the acquisition but not the maintenance of ethanol consumption in the
alcohol-preferring P line of rats. Alcoholism: Clinical and Experimental Research 21: 1042-1046.
86. Ikemoto, S., Glazier, B.S., Murphy, J.M., and McBride, W.J. (1997). Role of dopamine D1 and D2
receptors of the nucleus accumbens in mediating reward. Journal of Neuroscience 17: 8580-8587.
87. June, H.L., Zucarelli, D., Torres, L., Craig, K.S., DeLong, J., Allen, A. Braun, M.R., Cason, C.R., and
Murphy, J.M. (1998). High affinity benzodiazepine antagonists reduce ethanol-reinforced
responding maintained by ethanol presentation in ethanol-preferring rats. Journal of Pharmacology
and Experimental Therapeutics 284: 1006-1914.
88. June, H.L., Torres, L., Cason, C.R., Hwang, B.H., Braun, M.R., and Murphy, J.M. (1998). The
novel benzodiazepine inverse agonist RO19-4603 antagonizes ethanol motivated behaviors:
Neuropharmacological studies. Brain Research 784:256-275.
89. June, H.L., Dejaravu, S.L., Eggers, M.W., Williams, J.A., Cason, C.R., Greene, T.L., Leviege, T.,
Braun, M.R., Torres, L., and Murphy, J.M. (1998). Benzodiazepine receptor antagonists modulate
the actions of ethanol in alcohol-preferring and -nonpreferring rats. European Journal of
Pharmacology, 342: 139-151.
90. Ikemoto, S., Glazier, B.S., Murphy, J.M., and McBride, W.J. (1998). Rats self-administer carbachol
directly into the nucleus accumbens. Physiology & Behavior, 63: 811-814.
91. Ikemoto, S., Murphy, J.M., and McBride, W.J. (1998). Regional differences within the rat ventral
tegmental area for muscimol self-infusions. Pharmacology Biochemistry and Behavior 61:87-92.
92. McKinzie, D.L., Eha, R., Cox, R. Stewart, R.B., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.K. (1998). Serotonin3 receptor antagonism of alcohol intake: Effects of drinking conditions. Alcohol
15:291-298.
93. McKinzie, D.L., Nowak, K.L., Yorger, L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K.
(1998) The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant
access conditions. Alcoholism: Clinical and Experimental Research 22: 1170-1176.
94. McKinzie, D.L., Nowak, K. L., Murphy, J.M., Li, T.-K., Lumeng, L., and McBride, W.J. (1998)
Development of alcohol drinking in rat lines selectively bred for divergent alcohol preference.
Alcoholism: Clinical and Experimental Research 22: 1584-1590.
95. Nowak, K.L., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1998) Blocking GABAA
receptors in the anterior ventral tegmental area attenuates ethanol intake of the alcohol-preferring P
rat. Psychopharmacology 139: 108-116.
96. McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1999). Rat lines selectively
bred for alcohol preference: A potential animal model for adolescent alcohol drinking. In: J.H.
Hannigan, L.P. Spear, N.E. Spear, and C. Goodlett (Eds.), Alcohol and Alcoholism: Effects on Brain
and Development. Lawrence Erlbaum Associates, Erlbaum. Mahwah, NJ, pp. 135-160.
97. McKinzie, D.L., Rodd, Z.A., Dagon, C.L., Murphy, J.M., and McBride, W.J. (1999). Cocaine is selfadministered into the shell region of the nucleus accumbens in Wistar rats. Annals of the New York
Academy of Sciences 877: 788-791.
98. McBride, W.J., Murphy, J.M., and Ikemoto, S. (1999) Localization of brain reinforcement
mechanisms: Intracranial self-administration and intracranial place conditioning studies. Behavioural
Brain Research 101: 129-152.
James M. Murphy
17
99. Nowak, K.L., McKinzie, D.L., McBride, W.J., and Murphy, J.M. (1999). Patterns of ethanol and
saccharin intake in P rats under limited-access conditions. Alcohol 19: 85-96.
100. McKinzie, D.L., Cox, R., Murphy, J.M., Li, T.-K. Lumeng, L., and McBride, W.J. (1999). Voluntary
ethanol drinking during the first three postnatal weeks in lines of rats selectively bred for divergent
ethanol preference. Alcoholism: Clinical and Experimental Research 23: 1892-1897.
101. Rodd-Henricks, Z.A., McKinzie, D.L., Shaikh, S.R., Murphy, J.M., McBride, W.J., Lumeng, L., and Li,
T.-K. (2000). The alcohol deprivation effect is prolonged in the alcohol preferring (P) rat after
repeated deprivations. Alcoholism: Clinical and Experimental Research 24: 8-16.
102. McKinzie, D.L., Sajdyk, T.J., McBride, W.J., Murphy, J.M., Lumeng, L., Li, T.-K., and Shekhar, A.
(2000). Acoustic startle and fear-potentiated startle responding in alcohol-preferring (P) and nonpreferring (NP) lines of rats. Pharmacology Biochemistry and Behavior 65:691-696.
103. Nowak, K.L., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2000) Involvement of
dopamine D2 autoreceptors in the ventral tegmental area on alcohol and saccharin intake of the
alcohol preferring P rat. Alcoholism: Clinical and Experimental Research 24: 476-483.
104. Nowak, K.L., Ingraham, C.M., McKinzie, D.L., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy,
J.M. (2000) An assessment of novelty-seeking behavior in alcohol-preferring and non-preferring
rats. Pharmacology Biochemistry and Behavior 66: 113-121.
105. Rodd-Henricks, Z.A., McKinzie, D.L., Crile, R.S., Murphy, J.M., and McBride, W.J. (2000) Regional
heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of
Wistar rats. Psychopharmacology 149: 217-224
106. Engleman, E.A., McBride, W.J., Wilber, A.A., Shaikh, S.R., Eha, R.D., Lumeng, L., Li, T.-K., and
Murphy, J.M. (2000) Reverse microdialysis of a dopamine uptake inhibitor in the nucleus
accumbens of alcohol-preferring rats: Effects on dialysate dopamine levels and ethanol intake.
Alcoholism: Clinical and Experimental Research 24: 795-801
107. Rodd-Henricks, Z.A., McKinzie, D.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2000)
The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is
dependent upon repeated deprivations. Alcoholism: Clinical and Experimental Research 24: 747753
108. Rodd-Henricks, Z.A., McKinzie, D.L., Edmundson, V.E., Dagon, C.L., Murphy, J.M., McBride, W.J.,
Lumeng, L., and Li, T.-K. (2000) Effects of 5-HT3 receptor antagonists on daily alcohol intake under
acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats. Alcohol 21: 73-85
109. McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (2000) Effects of MDL72222,
a serotonin3 antagonist, on operant responding for ethanol by alcohol-preferring P rats. Alcoholism:
Clinical and Experimental Research 24: 1500-1504.
110. Jones, A.E., McBride, W.J., Murphy, J.M., Lumeng, L., Li, T.-K., Shekhar, A., and McKinzie, D.L.
(2000) Effects of ethanol on startle responding in alcohol-preferring (P) and -nonpreferring (NP) rats.
Pharmacology Biochemistry and Behavior 67: 313-318.
111. Bell, R.L., McKinzie, D.L., Murphy, J.M., and McBride, W.J. (2000) Sensitivity and tolerance to the
motor impairing effects of moderate doses of ethanol. Pharmacology Biochemistry and Behavior 67:
583-586.
112. Badia-Elder, N.E., Stewart, R.B., Powrozek, T.A., Roy, K.F., Murphy, J.M., and Li, T.-K. (2001)
Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol preferring (P), and nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 25: 386-390
113. Bell, R.L., Stewart, R. B., Woods, J.E., II, Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J
(2001) Responsivity and development of tolerance to the motor impairing effects of moderate doses
of ethanol in alcohol-preferring (P) and -nonpreferring (NP) rat lines. Alcoholism: Clinical and
Experimental Research 25: 644-650
114. Smith, D.G., Learn, J.E., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2001) Long-term
effects of alcohol drinking on cerebral glucose utilization in alcohol-preferring P rats. Pharmacology
Biochemistry and Behavior 69: 543-553.
115. Rodd-Henricks, Z.A., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K.
(2001) Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on
alcohol intake of alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 25:
1140-1150.
116. Smith, D.G., Learn, J.E., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2001) Alcoholnaive alcohol-preferring (P) rats exhibit higher local cerebral glucose utilization than alcohol nonpreferring (NP) and Wistar rats. Alcoholism: Clinical and Experimental Research 25: 1309-1316.
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117. McKinzie DL, McBride WJ, Murphy JM, Lumeng L, Li T-K. (2002) Effects of amphetamine on
locomotor activity in adult and periadolescent alcohol-preferring P and -nonpreferring NP rats.
Pharmacology Biochemistry and Behavior 71: 29-36.
118. Melendez RI, Rodd-Henricks ZA, Engleman EA, Li T-K, McBride WJ, Murphy JM. (2002)
Microdialysis of dopamine in the nucleus accumbens of alcohol preferring (P) rats during
anticipation and operant self-administration of ethanol. Alcoholism: Clinical and Experimental
Research 26: 318-325.
119. Smith DG, Learn JE, McBride WJ, Lumeng L, Li T-K, Murphy JM. (2002) Cerebral glucose utilization
after relapse in ethanol drinking in alcohol-preferring P rats. Alcohol 27:115-126.
120. Bell RL, Rodd-Henricks ZA, Webster AA, Lumeng L, Li T-K, McBride WJ, Murphy JM. (2002) Heart
rate and motor activiating effects of orally self-administered ethanol in alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 26: 1162-1170.
121. Murphy JM, Stewart RB, Bell RL, Badia-Elder N E, Carr LG, McBride WJ, Lumeng L, Li T-K. (2002)
Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for
high and low alcohol preference. Behavior Genetics 32: 363-388.
122. Rodd-Henricks ZA, McKinzie DL, Li T-K, Murphy JM, McBride WJ. (2002) Cocaine is selfadministered into the shell but not the core of the nucleus accumbens of Wistar rats. Journal of
Pharmacology and Experimental Therapeutics 303: 1216-1226.
123. Rodd-Henricks ZA, Bell RL, Kuc KA, Murphy JM, McBride WJ, Lumeng L, Li T-K. (2002) Effects of
ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and
expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats. I. Periadolescent
exposure. Alcoholism: Clinical and Experimental Research 26: 1632-1641.
124. Rodd-Henricks ZA, Bell RL, Kuc KA, Murphy JM, McBride WJ, Lumeng L, Li T-K. (2002) Effects of
ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and
expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats. II. Adult exposure.
Alcoholism: Clinical and Experimental Research 26: 1642-1652.
125. Rodd-Henricks ZA, McKinzie DL, Melendez RI, Berry N, Murphy JM, McBride WJ. (2003) Effects of
serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral
tegmental area of Wistar rats. Psychopharmacology 165: 252-259.
126. Engleman EA, McBride WJ, Lumeng L, Li T-K, Murphy JM. (2003) Ethanol drinking experience
attenuates (-) sulpiride-induced increases in extracellular dopamine levels in the nucleus
accumbens of alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 27: 424431.
127. Melendez RI, Rodd-Henricks ZA, McBride WJ, Murphy JM. (2003) Alcohol stimulates the release of
dopamine in the ventral pallidum but not in the globus pallidus: A dual-probe microdialysis study.
Neuropsychopharmacology 28: 939-946.
128. Gilpin NW, Stewart RB, Murphy JM, Li T-K, Badia-Elder NE. (2003) Neuropeptide Y reduces oral
ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence.
Alcoholism: Clinical and Experimental Research 27: 787-794.
129. Bell RL, Rodd ZA, Hsu CC, Lumeng L, Murphy JM McBride, WJ. (2003). Amphetamine-modified
acoustic startle responding and prepulse inhibition in adult and adolescent P and NP rats.
Pharmacology Biochemistry and Behavior, 75: 163-171.
130. Bell RL, Rodd-Henricks ZA, Kuc KA, Lumeng L, Li T-K, Murphy JM, McBride WJ. (2003) Effects of
concurrent access to single concentration or multiple concentrations of ethanol on the intake of
ethanol by male and female periadolescent alcohol-preferring (P) rats. Alcohol 29: 137-148.
131. Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, Li T-K, McBride WJ. (2003) Effects of repeated
alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) rats.
Neuropsychopharmacology 28: 1614-1621.
132. Badia-Elder NE, Stewart RB, Powrozek TA, Murphy JM, Li T-K. (2003) Effects of neuropeptide Y
(NPY) on sucrose and ethanol intake and on anxiety-like behavior in high alcohol drinking (HAD)
and low alcohol drinking (LAD) rats. Alcoholism: Clinical and Experimental Research 27: 894-899
133. Rodd ZA, Melendez R, Bell RL, Kuc K, Zhang Y, Murphy JM, McBride WJ. (2004) Intracranial selfadministration of ethanol within the ventral tegmental area of male Wistar rats: Evidence for
involvement of dopamine neurons. Journal of Neuroscience 24: 1050-1057.
134. Thielen RJ, Engleman EA, Rodd ZA, Murphy JM, Lumeng L, Li T-K, McBride WJ. (2004) Ethanol
drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of
alcohol-preferring rats. Journal of Pharmacology and Experimental Therapeutics 309: 216-225.
James M. Murphy
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135. McBride WJ, Lovinger DM, Machu T, Thielen RJ, Rodd ZA, Murphy JM, Roache JD, Johnson BA.
(2004) Serotonin-3 Receptors in the Actions of Alcohol, Alcohol Reinforcement and Alcoholism.
Alcoholism: Clinical and Experimental Research 28: 257-267.
136. Rodd ZA, Bell RL, McKinzie DL, Webster AA, Murphy JM, Lumeng L, Li T-K, McBride WJ. (2004)
Low-dose stimulatory effects of ethanol during adolescence in rat lines selectively bred for high
alcohol intake. Alcoholism: Clinical and Experimental Research 28: 535-543.
137. Melendez RI, Rodd ZA, McBride WJ, Murphy JM. (2004) Involvement of the mesopallidal dopamine
system in ethanol reinforcement. Alcohol 32: 137-144.
138. Gilpin NW, Stewart RB, Elder RL, Kho Y, Murphy JM, Li T-K, Badia-Elder NE. (2004) Sedative and
motor-impairing effects of neuropeptide Y in selectively bred P and NP rats. Pharmacology
Biochemistry and Behavior 78: 65-73.
139. Rodd ZA, Bell RL, Melendez RI, Kuc KA, Lumeng L, Li T-K, Murphy JM, McBride WJ. (2004)
Comparison of intracranial self-administration of ethanol within the posterior ventral tegmental area
between alcohol-preferring (P) and Wistar rats. Alcoholism: Clinical and Experimental Research 28:
1212-1219.
140. Engleman EA, Ingraham CM, O’Brien CE, McBride WJ, Murphy JM. (2004) Effect of housing
conditions on sulpiride-induced increases in extracellular dopamine (DA) levels in the nucleus
accumbens of alcohol-preferring (P) rats. Brain Research 1022: 247-250.
141. Gilpin NW, Stewart RB, Murphy JM, Badia-Elder NE. (2004) Neuropeptide Y (NPY) in the
paraventricular nucleus of the hypothalamus increases ethanol intake in high- and low-alcoholdrinking rats. Alcoholism: Clinical and Experimental Research 28: 1492-1498.
142. Bell RL, Rodd ZA, Hsu CC, Lumeng L, Li T-K, Murphy JM, McBride WJ. (2004) Effects of
concurrent access to ethanol to a single concentration or multiple concentrations of ethanol on
alcohol intake by periadolescent high-alcohol-drinking rats. Alcohol 33: 107-115.
143. Rodd ZA, Bell RL, Sable HJK, Murphy JM, McBride WJ. (2004) Recent advances in animal models
of alcohol craving and relapse. Pharmacology Biochemistry and Behavior 79: 439-450.
144. Bell RL, Rodd ZA, Boutwell CL, Hsu CC, Lumeng L, Murphy JM, Li T-K, McBride WJ. (2004) Effects
of long-term episodic access to ethanol on the expression of an alcohol deprivation effect in low
alcohol-consuming rats. Alcoholism: Clinical and Experimental Research 28: 1867-1874.
145. Bell RL, Rodd ZA, Murphy JM, McBride WJ. (2005). Use of selectively bred alcohol-preferring rats
to study alcohol abuse, relapse and craving. In: Comprehensive Handbook of Alcohol Related
Pathology, pp. 1517-1535, V.R. Preedy and R.R. Watson (Eds), Academic Press, Elsevier Science:
New York.
146. Rodd ZA, Bell RL, Zhang Y, Murphy JM, Goldstein A, Zaffaroni A, Li T-K, McBride WJ. (2005)
Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the
ventral tegmental area of alcohol-preferring (P) rats: Involvement of dopamine and serotonin.
Neuropsychopharmacology 30: 330-338.
147. Melendez RI, Rodd ZA, McBride WJ, Murphy JM. (2005) Dopamine receptor regulation of ethanol
intake and extracellular dopamine in the ventral pallidum of alcohol preferring (P) rats. Drug and
Alcohol Dependence 77: 293-301.
148. Rodd ZA, Bell, RL McQueen VK, Davids MR, Hsu CC, Murphy JM, Li T-K, Lumeng L, McBride WJ.
(2005) Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior
ventral tegmental area to the reinforcing effects of ethanol. Alcoholism: Clinical and Experimental
Research 29: 358-366.
149. McBride WJ, Bell RL, Rodd ZA, Strother WN, Murphy JM. (2005) Adolescent alcohol drinking and
its long-range consequences: Studies with animal models. In Recent Developments in Alcoholism,
Vol. 17 Alcohol Problems in Adolescents and Young Adults (M. Galanter, ed) Kluwer
Academic/Plenum Publishers, New York.
150. Rodd ZA, Bell RL, Kuc KA, Zhang Y, Murphy JM, McBride WJ (2005) Intracranial self-administration
of cocaine within the posterior ventral tegmental area of Wistar rats: Evidence for involvement of
serotonin-3 receptors and dopamine neurons. Journal of Pharmacology and Experimental
Therapeutics 313: 134-145, 2005.
151. Gilpin NW, Stewart RB, Murphy JM, Badia-Elder NE. (2005) Sensitized effects of neuropeptide Y on
multiple ingestive behaviors in P rats following ethanol abstinence. Pharmacol Biochemistry and
Behavior 81: 740-749.
James M. Murphy
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152. Rodd ZA, Bell RL, McQueen VK, Davids MR, Hsu CC, Murphy JM, Li TK, Lumeng L, McBride WJ.
(2005) Prolonged increase in the sensitivity of the posterior ventral tegmental area to the reinforcing
effects of ethanol following repeated exposure to cycles of ethanol access and deprivation. Journal
of Pharmacology and Experimental Therapeutics. 315: 648-57.
153. Bell RL, Rodd, ZA, Sable HJK, Schultz JA, Hsu CC, Lumeng L, Murphy JM, McBride WJ (2006)
Daily patterns of ethanol drinking in peri-adolescent and adult alcohol-preferring (P) rats.
Pharmacology Biochemistry and Behavior, 83: 35-46.
154. Engleman EA, Ingraham CM, McBride WJ, Lumeng L, Murphy JM (2006) Extracellular dopamine
levels are lower in the medial prefrontal cortex of alcohol-preferring (p) rats than wistar rats. Alcohol,
38: 5-12.
155. Rodd ZA, McKinzie DL, Bell RL, McQueen VK, Murphy JM, Schoepp DD, McBride WJ. (2006) The
metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol
self-administration in alcohol-preferring (P) rats. Behavioural Brain Research 171: 207-215.
156. Oster SM, Toalston JE, Kuc KA, Pommer TJ, Murphy JM, Lumeng L, Bell RL, McBride WJ, Rodd
ZA. (2006) Effects of multiple alcohol deprivations on operant ethanol self-administration by highalcohol-drinking replicate rat lines. Alcohol 38: 155-164
157. Bell RL, Rodd, ZA, Lumeng L, Murphy JM, McBride WJ (2006) The alcohol-preferring P rat and
animal models of excessive alcohol drinking. Addiction Biology, 11: 270-288.
158. Carroll MR, Rodd, ZA, Murphy JM and Simon JR (2006) Chronic ethanol consumption increases
dopamine uptake in the nucleus accumbens of high alcohol drinking rats. Alcohol 40: 103-109.
159. Bell RL, Rodd, ZA,Schultz JA, Peper Cl, Lumeng L, Murphy JM, McBride WJ (2008) Effects of short
deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high
alcohol-consuming rats. Alcohol 42: 407-416.
160. Toalston JE, Oster SM, Kuc KA, Pommer TJ, Murphy JM, Lumeng L, Bell RL, McBride WJ, Rodd
ZA. (2008) Effects of alcohol and saccharin deprivations on concurrent ethanol and saccharin
operant self-administration by alcohol-preferring (P) rats. Alcohol 42: 277-284
161. Engleman EA, Ingraham CM, Franklin KM, Keith CM, McClaren JA, Schultz JA, Morzorati SL,
O’Conner S, Thielen RJ, Murphy JM, McBride WJ (2008) In vivo time-course changes in ethanol
levels sampled with subcutaneous microdialysis. Alcoholism: Clinical and Experimental Research,
32: 435-442.
162. Bell RL, Rodd ZA, Toalston JE, McKinzie DL, Lumeng L, Li TK, McBride WJ, Murphy JM (2008)
Autonomic activation associated with ethanol self-administration in adult female P rats. Pharmacol
Biochem Behav. 91:223-232.
163. Engleman EA, Rodd ZA, Bell RL and Murphy JM (2008) The role of 5-HT3 receptors in drug abuse
and as a target for pharmacotherapy. CNS & Neurological Disorders - Drug Targets, 7: 454-467.
164. Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, McBride WJ. (2009) Effects of concurrent access
to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcoholdrinking (HAD) rats. Addiction Biology 14: 152-164.
James M. Murphy
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Manuscripts in Press
Franklin KM, Engleman EA, Ingraham CM, McClaren JA, Keith CM; McBride WJ and Murphy JM (in
press) A single, moderate ethanol exposure alters Extracellular dopamine levels and dopamine D2
receptor function in the nucleus accumbens of Wistar rats. Alcoholism: Clinical and Experimental
Research
Manuscripts Submitted for Publication or Under Revision
Engleman EA, Ding Z-M, Oster SM, Toalston JE, Bell RL, Murphy JM, McBride WJ and Rodd ZA (under
revision) Ethanol is Self-Administered into the Nucleus Accumbens Shell, but not the Core: Evidence
of Genetic Sensitivity. Alcoholism: Clinical and Experimental Research
James M. Murphy
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Published Abstracts and Presentations at Professional Meetings
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Murphy, J.M., and Culbertson, J.L. (1971). Failure to find escape from noncontingent positive brain
stimulation in rats. Presented at the annual meeting of the Eastern Psychological Association, New
York, NY.
Murphy, J.M., and Nagy, Z.M. (1975). Acceleration of central nervous system maturation results in
earlier onset of memory capacities in neonatal mice. Presented at the annual meeting of the
Midwestern Psychological Association, Chicago, IL.
Gold, P.E., and Murphy, J.M. (1979). Brain norepinephrine and retrograde amnesia. Society for
Neuroscience Abstracts 5: 316.
Murphy, J.M., Cooley, S.G., and Gold, P.E. (1979). Enhancement of 24-hour retention in
preweanling rats by post-training hormone administration. Society for Neuroscience Abstracts 5:
321.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1980). The effects of chronic alcohol
consumption on the levels of monoamines in different CNS regions of alcohol-preferring rats.
Society for Neuroscience Abstracts 6: 610.
Flint, R.S., Murphy, J.M., Cinancone, M.T., and McBride, W.J. (1981). In vitro release of
endogenous dopamine and 3,4-dihydroxyphenylacetic acid from rat striatum. Society for
Neuroscience Abstracts 7: 198.
McBride, W.J., Flint, R.S., Ciancone, M.T., and Murphy, J.M. (1981). In vitro release of endogenous
monoamines and amino acids from nine CNS regions. Society for Neuroscience Abstracts 7: 199.
Murphy, J.M., McBride, W.J., Ciancone, D.J., Lumeng, L., and Li, T.-K. (1981). The effect of chronic
alcohol consumption on neurotransmitter systems in alcohol-preferring rats. Society for
Neuroscience Abstracts 7: 314.
Flint, R.S., Calkins, P.M., Murphy, J.M., and McBride, W.J. (1982). Transmitter interactions
assessed by changes of endogenous release. Transactions of the American Society for
Neurochemistry 13: 278.
McBride, W.J., and Murphy, J.M. (1984). Effects of ethanol on monoamine and amino acid release.
Alcoholism: Clinical and Experimental Research 8: 106.
Murphy, J.M., Waller, M.B., McBride, W.J., Lumeng, L., and Li, T.-K. (1984). Serotonin and
norepinephrine uptake inhibitors attenuate ethanol intake in the P (alcohol-preferring) line of rats.
Alcoholism: Clinical and Experimental Research 8: 109.
McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1985). Effects of ethanol on transmitter
release from cortical slices of P rats. Alcoholism: Clinical and Experimental Research 9: 207.
McBride, W.J., Murphy, J.M., Waller,M.B., Lumeng, L., and Li, T.-K. (1985). Neurochemical
evidence for the development of neuronal tolerance in the alcohol-preferring P line of rats. Society
for Neuroscience Abstracts 11: 291.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1985). CNS amino acid transmitter levels in
P (alcohol-preferring) rats and effects of ethanol. Alcoholism: Clinical and Experimental Research 9:
207.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1985). Regional brain serotonin content in
alcohol-preferring and -nonpreferring rats from the N/Nih heterogeneous stock. Society for
Neuroscience Abstracts 11: 290.
Waller, M.B., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1985). Studies on the
reinforcing properties of ethanol in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental
Research 9: 207.
Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Acquisition of tolerance
to ethanol through free-choice drinking in alcohol-preferring (P) rats. Alcoholism: Clinical and
Experimental Research 10: 111.
Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Persistence of acute
tolerance in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 10: 111.
Li, T.-K., Lumeng, L., McBride, W.J., and Murphy, J.M. (1986). Different alcohol-evoked responses
in rodent lines selected for high and low voluntary alcohol drinking. Third congress of the
International Society for Biomedical Research on Alcoholism, Helsinki, Finland, June 25-30.
McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1986). Levels of monoamines and
metabolites in the nucleus accumbens and frontal cortex of selectively bred alcohol preferring and
nonpreferring lines of rats. Society for Neuroscience Abstracts 12: 1143.
James M. Murphy
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Murphy, J.M., Gongwer, M., Elsner, G., and McBride, W.J. (1986). Acute ethanol intoxication
decreases aspartate content in the CNS of Wistar rats. Alcoholism: Clinical and Experimental
Research 10: 117.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Acute ethanol intoxication elevates
regional brain monoamine metabolites in the Wistar rat. Alcoholism: Clinical and Experimental
Research 10: 117.
Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1987). The effects of fluoxetine
on ethanol intake in the alcohol-nonpreferring (NP) line of rats. Society for Neuroscience Abstracts
13: 338.
Khatib, S.A., Murphy, J.M., and McBride, W.J. (1987). Differential effects of acute ethanol on the
dopaminergic and serotonergic systems in rat brain. Alcoholism: Clinical and Experimental
Research 11: 203.
McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1987). Involvement of monoamines in
drinking behavior of selectively bred alcohol-preferring rats. Presented at the 95th annual meeting
of the American Psychological Association, New York, NY, August 28-September 1.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1987). Effects of serotonergic agents on
ethanol intake of the high alcohol drinking (HAD) line of rats. Alcoholism: Clinical and Experimental
Research 11: 208.
Murphy, J.M., Morzorati, S.L., Hingtgen, J.N., Matney, S.L., Lumeng, L., and Li, T.-K. (1987).
Response suppression to serotonergic drugs is attenuated in the P line of alcohol-preferring rats.
Society for Neuroscience Abstracts 13: 340.
Gongwer, M.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1988). Absence of
tolerance in monoamine systems to acute ethanol in the alcohol-preferring P line of rats.
Alcoholism: Clinical and Experimental Research 12: 308.
Gongwer, M., Murphy, J.M., and McBride, W.J. (1988). Effect of Ro15-4513 on acute
ethanol-induced changes in intoxication score, ambulatory activity and monoamine metabolite
levels. Society for Neuroscience Abstracts 14: 521.
Levy, A.D., McBride, W., Murphy, J., Lumeng, L., and Li, T.-K. (1988). Genetically selected lines of
high- and low-alcohol-drinking rats: Operant studies. Society for Neuroscience Abstracts 14: 41.
Li, T.-K., Lumeng, L., Froehlich, J.C., Murphy, J.M., and McBride, W.J. (1988). Genetic influence on
response to the reinforcing properties of ethanol in rats. Fourth Congress of the International
Society for Biomedical Research on Alcoholism Abstracts, Kyoto, Japan, June 26-July 2.
Li, T.-K., Lumeng, L., McBride, W.J., Murphy, J.M., Froehlich, J.C., and Morzorati, S. (1988).
Behavioral and neurochemical associations of alcohol-seeking behavior. Fourth Congress of the
International Society for Biomedical Research on Alcoholism Abstracts, Kyoto, Japan, June 26-July
2.
McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1988). Effects of Ro 15-4513 on ethanol
intake of the alcohol-preferring P line of rats. Alcoholism: Clinical and Experimental Research 12:
315.
Murphy, J.M., Gongwer, M.A., McBride, W.J., Lumeng, L., and Li, T.-K. (1988). Contents of
serotonin, dopamine and their metabolites in the CNS of high- and low-alcohol-drinking lines of rats.
Society for Neuroscience Abstracts 14: 195.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1988). Effects of serotonin and dopamine
agents on ethanol intake of alcohol-preferring P rats. Alcoholism: Clinical and Experimental
Research 12: 306.
Engleman, E.A., Hingtgen, J.N., Zhou, F.C., Murphy, J.M., and Aprison, M.H. (1989). Potentiated
5-hydroxytryptophan (5-HTP) response suppression following 5,7-dihydroxytryptamine (5,7-DHT)
raphe lesions in rats tested in a model of depression. Society for Neuroscience Abstracts 15: 1282.
Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L. and Li, T.-K. (1989). Persistence of acute
tolerance to ethanol in the P line of rats does not require performance while intoxicated. Society for
Neuroscience Abstracts 15: 38.
Gatto, G.J., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989). Effects of serotonin
(5HT) agonists on alcohol drinking behavior of the NP (alcohol-nonpreferring) line of rats.
Alcoholism: Clinical and Experimental Research 13: 305.
Gatto, G.J., Murphy, J.M., Stewart, R.B., McBride, W.J., Lumeng, L., and Li, T.-K. (1989). Passive
avoidance behavior in alcohol-preferring and -nonpreferring lines of rats. Alcoholism: Clinical and
Experimental Research 13: 306.
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Levy, A.D., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989). Effects of
intra-accumbens infusions of DA and 5-HT on ethanol intake of alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 13: 305.
Levy, A.D., Murphy, J.M., McBride, W.J., Lumeng, L. and Li, T.-K. (1989). Microinjection of the
serotonin agonist TFMPP into the nucleus accumbens increases ethanol drinking in P rats. Society
for Neuroscience Abstracts 15: 59.
Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1989). Effects of spiroxatrine on the
fluoxetine-induced reduction of ethanol intake by alcohol-preferring (P) rats. Alcoholism: Clinical
and Experimental Research 13: 305.
Murphy, J.M., McBride, W.J., Lumeng, L., Li, T.-K. and Wong, D.T. (1989). Suppression of alcohol
and food intake by LY264453, a new inhibitor of serotonin (5HT) and norepinephrine (NE) uptake.
Society for Neuroscience Abstracts 15: 58.
Stewart, R.B., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989). Differences in performance on
anxiety tests in rats genetically selected for ethanol preference. Society for Neuroscience Abstracts
15: 61.
Zhou, F.C. and Murphy, J.M. (1989). A serotonergic neurotrophic factor is induced by lesioning
dopamine neurons in substantia nigra of adult rat. Society for Neuroscience Abstracts 15: 1363.
Engleman, E.A., Hingtgen, J.N., Murphy, J.M., Zhou, F.C., and Aprison, M.H. (1990). Attenuated
5-hydroxytryptophan (5-HTP) induced response suppression following pretreatment with a selective
5-HT2 receptor agonist (DOI) in an animal model of depression. Society for Neuroscience Abstracts
16: 850.
Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1990). Intracranial
self-administration of ethanol into the ventral tegmental area of alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 14: 291.
Gatto, G.J., Murphy, J.M., Stewart, R.B., and McBride, W.J. (1990). Passive avoidance behavior in
alcohol-preferring and -nonpreferring lines of rats. Society for Neuroscience Abstracts 16: 434.
Levy, A.D., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1990). 5-HT3 but not 5-HT2
receptors in the nucleus accumbens may mediate alcohol drinking in alcohol-preferring (P) rats.
Society for Neuroscience Abstracts 16: 258.
Levy, A.D., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1990). Microinjection of
sulpiride into the nucleus accumbens increases ethanol drinking in alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 14: 321.
McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1990). Serotonin and dopamine systems
regulating alcohol intake. Presented at the joint meeting of the International Society for Biomedical
Research on Alcoholism and the Research Society on Alcoholism. Toronto, Ontario, Canada, June
17-22.
Murphy, J.M., Engleman, E., Burns, S., McBride, W.J., and Hingtgen, J.N. (1990). Operant
response suppression by the 5HT2 agonist DOI in alcohol-preferring (P) and -nonpreferring (NP)
rats. Society for Neuroscience Abstracts 16: 434.
Stewart, R.B., Murphy, J.M., Lumeng, L., and Li, T.-K. (1990). Performance on the plus-maze test
of anxiety in Wistar, alcohol-preferring (P) and -nonpreferring (NP) lines of rats: Effects of ethanol
and chlordiazepoxide (CDP). Society for Neuroscience Abstracts 16: 756.
Stewart, R.B., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1990) Tolerance to the
aversive effects of ethanol in selectively-bred alcohol-preferring (P) rats. Alcoholism: Clinical and
Experimental Research 14: 342.
Engleman, E.A., Hingtgen, J.N., Murphy, J.M., Zhou, F.C., and Aprison, M.H. (1991). LY53857
blocks response suppression (RS) induced with 5-HTP and DOI but not with 8-OH-DPAT in an
animal model of depression. Society for Neuroscience Abstracts 17: 281.
Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1991). Ethanol-associated
conditioned reinforcement in alcohol- preferring (P) rats. Alcoholism: Clinical and Experimental
Research 15: 313.
Murphy, J.M., Gatto, G.J., Dean, R.A., and Bosron, W.F. (1991). Intracranial self-administration
(ICSA) of ethylcocaine (EC), an active metabolite of ethanol and cocaine, to the prefrontal cortex in
rats. Alcoholism: Clinical and Experimental Research 15: 315.
Murphy, J.M., Stewart, R.B., Lumeng, L., Li, T.-K., and McBride, W.J. (1991). Effects of
serotonergic agents on ethanol drinking in the P line of alcohol-preferring rats. Society for
Neuroscience Abstracts 17: 1424.
James M. Murphy
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Stewart, R.B., Li, T.-K., McBride, W.J., Lumeng, L., and Murphy, J.M. (1991). Chronic tolerance in
ethanol-preferring P rats and enhanced responsiveness in ethanol-nonpreferring NP rats to the
effects of ethanol on spontaneous motor activity (SMA). Alcoholism: Clinical and Experimental
Research 15: 317.
Stewart, R.B., Russell, R.N., Franada, F., and Murphy, J.M. (1991). Effects of amphetamine and
scopolamine on motor activity in alcohol-preferring (P) and -nonpreferring (NP) rats. Society for
Neuroscience Abstracts 17: 1424.
Dyr, W., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1992). The effects of D1 and D2
dopamine receptor agents on ethanol consumption in the HAD line of high alcohol drinking rats.
Alcoholism: Clinical and Experimental Research 16: 396.
Engleman, E.A., Murphy, J.M., Zhou, F.C., Aprison, M.H., and Hingtgen, J.N. (1992). Operant
response suppression (RS) induced with systemic administration of 5-hydroxytryptophan (5-HTP) is
centrally mediated. Society for Neuroscience Abstracts 18: 1536.
Gatto, G.J., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.J. (1992). Effect of environmental
cues on intracranial self- administration (ICSA) of ethanol into the ventral tegmental area (VTA) in
alcohol-preferring (P) rats. Presented at the 18th annual Convention of the Association for Behavior
Analysis: International. San Francisco, CA, May 24-28.
Gatto, G.J., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.J. (1992). Extinction of intracranial
self-administration (ICSA) of ethanol into the ventral tegmental area (VTA) in alcohol-preferring (P)
rats. Alcoholism: Clinical and Experimental Research 16: 367.
Godfrey, C.D., Jing, S.L., Stewart, R.B., Froehlich, J.C., and Murphy, J.M. (1992). Comparison of
alcohol-preferring (P) and -nonpreferring (NP) rats in a forced-swims stress test. Society for
Neuroscience Abstracts 18: 541.
Godfrey, C.D., Stewart, R.B., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1992). The
effects of 8-OH-DPAT on behavioral activity in the alcohol-preferring P and -nonpreferring NP rats.
Alcoholism: Clinical and Experimental Research 16: 406.
Lovell, T.A., Engleman, E.A., Aprison, M.H., Hingtgen, J.N., and Murphy, J.M. (1992). 5-HT1A
receptor agonist and antagonist effects on suppression of responding in a model of depression.
Society for Neuroscience Abstracts 18: 1536.
McBride, W.J., Murphy, J.M., Levy, A.D., Gatto, G.J., Yoshimoto, K., Lumeng, L., and Li, T.-K.
(1992). CNS mechanisms of alcohol drinking in genetically selected lines of rats. Presented at the
Sixth Congress of the International Society for Biomedical Research on Alcoholism. Bristol,
England, June 21-26.
McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1992). Serotonin regulation of alcohol
drinking. Presented at the Second International Symposium on Serotonin from Cell Biology to
Pharmacology and Therapeutics. Houston, Texas, September 15-18.
Murphy, J.M., McBride, A.W., Wlodarek, C.A., McBride, W.J., Lumeng, L., and Li, T.-K. (1992).
Differences in the ontogeny of locomotor activity between the alcohol-preferring P and
-nonpreferring NP rats. Alcoholism: Clinical and Experimental Research 16: 406.
Stewart, R.B., Li, T.-K., McBride, W.J., Lumeng, L., and Murphy, J.M. (1992). Chronic ethanol
consumption in alcohol-preferring P rats attenuates subsequent conditioned place aversion
produced by ethanol injections. Alcoholism: Clinical and Experimental Research 16: 395.
Stewart, R.B., Li, T.-K., McBride, W.J., Lumeng, L., and Murphy, J.M. (1992). Place aversion
conditioning: Genetic differences in the aversive effects of ethanol in alcohol-preferring P and
-nonpreferring NP rats. Alcoholism: Clinical and Experimental Research 16: 395.
Stewart, R.B., Russell, R.N., Li, T.-K., and Murphy, J.M. (1992). Consumption of sweet, salty, sour
and bitter flavored solutions by selectively-bred alcohol-preferring P and -nonpreferring NP lines of
rats. Society for Neuroscience Abstracts 18: 541.
Dyr, W., Cox, R., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1993). Operant
responding for ethanol in high HAD and low LAD alcohol-drinking rats. Alcoholism: Clinical and
Experimental Research 17: 479.
Dyr, W., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1993). Multiple injections of 5-HT
antagonists reduce alcohol consumption of the P line of rats. Alcoholism: Clinical and Experimental
Research, 17: 482.
June, H.L., Green, T., Murphy, J.M., Lumeng, L., and Li, T.-K. (1993). Ro19-4603 selectively
attenuates ethanol intake in the alcohol-preferring P rats. Alcoholism: Clinical and Experimental
Research, 17: 481.
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Murphy, J.M., Dyr, W., McBride, W.J., Lumeng, L., and Li, T.-K. (1993). Sensitivity and tolerance to
the sedative effects of ethanol in the high- and low-alcohol-drinking (HAD and LAD) rats. Society for
Neuroscience Abstracts 19: 1455.
Zhou, F.C., Murphy, J., Lumeng, L., and Li, T.-K. (1993). Relationship of dopaminergic and
serotonergic neurons from raphe to nucleus accumbens in alcohol-preferring rats. Alcoholism:
Clinical and Experimental Research, 17: 479.
Chamberlain, J.K., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.J. (1994). Involvement of
serotonergic systems in sensitivity to ethanol. Alcoholism: Clinical and Experimental Research 18:
483.
Hewitt, R.L., June, H.L., Murphy, J.M., Mellor-Burke, J.J., Greene, T.L., Lin, M., Lumeng, L., and Li,
T.-K. (1994). Does tolerance develop to the ethanol suppressant effects of the benzodiazepine
inverse agonist, RO19-4603? Alcoholism: Clinical and Experimental Research 18: 487.
Ikemoto, S., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.J. (1994). Ethanol selfadministration into the VTA of the P rats using fixed ratio schedules. Alcoholism: Clinical and
Experimental Research 18: 518.
June, H.L., Chen, S.H.A., Duemler, S., Lin, M., Greene, T.L., Williams, J., Hewitt, R.L., MellorBurke, J.J., Lewis, M.J., and Murphy, J.M. (1994). Effects of RO19-4603 on the maintenance of
tolerance to a single dose of ethanol. Alcoholism: Clinical and Experimental Research 18: 521.
June, H.L., Murphy, J.M., Hewitt, R.L., Greene, T.L., Lin, M., Mellor-Burke, J.J., Chen, S.H.A.,
Lumeng, L., and Li, T.-K. (1994). Benzodiazepine receptor ligands with different intrinsic efficacies
alter ethanol intake in alcohol-nonpreferring (NP) rats. Alcoholism: Clinical and Experimental
Research 18: 487.
Katner, S.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1994). Muscarinic receptor
involvement in alcohol drinking and behavioral activity of P and NP rats. Alcoholism: Clinical and
Experimental Research 18: 487.
Russell, R.N., Froehlich, J.C., Stewart, R.B., Lumeng, L., Li, T.-K., and Murphy, J.M. (1994).
Comparison of alcohol-preferring P and -nonpreferring NP rats for the intravenous selfadministration (IVSA) of cocaine. Alcoholism: Clinical and Experimental Research 18: 519.
Russell, R.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1994). Effects of dopamine
D3 and D4 receptor agonists on ethanol consumption in high alcohol drinking (HAD) and alcoholpreferring (P) rats. Alcoholism: Clinical and Experimental Research 18: 488.
Duemler, S., June, H.L., Breen, T.E., Lewis, M.J., and Murphy, J.M. (1994). The benzodiazepine
inverse agonist RO19-4603 exerts prolonged antagonism of the locomotor depressant actions of
ethanol in alcohol-preferring (P) rats. Society for Neuroscience Abstracts 20: 499.
June, H.L., Greene, T.L., Lin, M., and Murphy, J.M. (1994). Differential sensitivity of the
benzodiazepine inverse agonist RO19-4603 on the locomotor depressant effects of ethanol in
alcohol-preferring (P) and -nonpreferring (NP) rats. Society for Neuroscience Abstracts 20: 1606.
Williams, J., June, H.L., Dejaravu, S., Lewis, M.J., and Murphy, J.M. (1994). The benzodiazepine
anatangonist CGS-8216 exerts prolonged and selective attenuation of ethanol intake in alcoholpreferring (P) rats. Society for Neuroscience Abstracts 20: 1606.
McKinzie, D.L., Eha, R., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1994). Early taste
aversion training is effective in preventing the onset of alcohol drinking in P and HAD rat lines.
Society for Neuroscience Abstracts 20: 1609.
Godfrey, C.D., Froehlich, J.C., Lumeng, L., Li, T.-K., and Murphy, J.M. (1994). Immobility in a swim
test is not associated with a genetic predisposition to alcohol preference. Society for Neuroscience
Abstracts 20: 1618.
June, H.L., Lewis, M.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1994). The benzodiazepine
antagonists CGS-8216 and ZK 93426 attenuate ethanol intake in alcohol preferring (P) rats.
American College of Neuropsychopharmacology Abstracts, 133.
June, H.L., Murphy, J.M., Lewis, M.J., Lumeng, L., and Li, T.-K. (1994). Differential sensitivity of the
benzodiazepine inverse agonist RO19-4603 on the locomotor depressant effects of ethanol in low
and high drinking F2 rats. American College of Neuropsychopharmacology Abstracts, 132.
Ikemoto, S., Glazier, B.S., Murphy, J.M., and McBride, W.J. (1995). Muscarinic receptors in the
nucleus accumbens mediate a reinforcing effect. Society for Neuroscience Abstracts 21: 1673.
Ikeomoto, S., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1995). Effects of 6-OHDA
lesions of the nucleus accumbens (ACB) on the acquisition and maintenance of alcohol drinking in
the aP line of rats. Alcoholism: Clinical and Experimental Research 19: 13A.
James M. Murphy
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June, H.L., Williams, J., Cason, C.R., Devaraju, S., Lin, M., Murphy, J.M., Lewis, M.J., Lumeng, L.,
and Li, T.-K. (1995). Low doses of gamma-hydroxybutyric acid (GHB) attenuate ethanol intake in
alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 19: 14A.
June, H.L., Murphy, J.M., Lewis, M.J. and Li, T.-K. (1995). The novel benzodiazepine partial
inverse agonist RO19-4603 produces selective and prolonged suppression of ethanol (EtOH) intake
and ethanol-reinforced responding in alcohol-preferring (P) rats. American College of
Neuropsychopharmacology 34: 96.
June, H.L., Cason, C.R., Braun, M.R., Torres, L., Allen, A., DeLong, J., Jackson, D., Murphy, J.M.,
Lewis, M.J., Lumeng, L., and Li, T.-K. (1995). Bretazenil exerts anxiolytic effects in alcoholpreferring (P) rats. Alcoholism: Clinical and Experimental Research 19: 65A.
Katner, S.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1995). Effects of nicotinic
agents on alcohol drinking and locomotor activity of P and NP rats. Alcoholism: Clinical and
Experimental Research 19: 12A.
Katner, S.N. McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1995). Involvement of the
pedunculopontine nucleus in regulating alcohol drinking. Society for Neuroscience Abstracts 21:
1699.
Lewis, M.J., June, H.L., Murphy, J.M., and Li, T.-K. (1995). Evaluation of high affinity
benzodiazepine partial agonists in alcohol-preferring (P) and nonpreferring (NP) rats. American
College of Neuropsychopharmacology 34: 195.
Li, T.-K., Lumeng, L., McBride, W.J., and Murphy, J.M. (1995). A pharmacogenetic rat model of
alcholism. American College of Neuropsychopharmacology 34: 12.
McBride, W.J., Cox, R., Eha, R., McKinzie, D.L., Lumeng, L., Li, T.-K., and Murphy, J.M., (1995).
Possible involvement of 5-HT-3 receptors in the anticipatory behavior of P rats for alcohol.
Alcoholism: Clinical and Experimental Research 19: 14A.
McKinzie, D.L., Cox, R., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1995). Postnatal
development of alcohol drinking behavior in P, NP and Wistar rats. Alcoholism: Clinical and
Experimental Research 19: 16A.
McKinzie, D.L., Eha, R., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1995). Ontogeny
of rapid tolerance to ethanol in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats.
Presented at the International Society for Developmental Psychobiology, San Diego, CA.
Craig, K., June, H.L., Braun, M.R., and Murphy, J.M. (1996). Benzodiazepine receptor antagonists
modulate the behavioral actions of ethanol. Alcoholism: Clinical and Experimental Research 20:
12A.
Zuccarelli, D., June, H.L., Durr, L.F., and Murphy, J.M. (1996). Benzodiazepine receptor
antagonists with different intrinsic efficacies modulate ethanol-reinforced responding in alcoholpreferring (P) rats. Alcoholism: Clinical and Experimental Research 20: 12A.
Cason, C.R., June, H.L., Matecka, D., and Murphy, J.M. (1996). Effects of the selective, high affinity
ligand ZG-63 for diazepam insensitive subtype of the benzodiazepine receptor on EtOH-reinforced
responding. Alcoholism: Clinical and Experimental Research 20: 12A.
Eggers, M.W., June, H.L., Ricks, D., and Murphy, J.M. (1996). The novel benzodiazepine agonist
RU 34000 and specific antagonist RU 40410 antagonize ethanol -reinforced responding in alcoholpreferring (P) rats. Alcoholism: Clinical and Experimental Research 20: 12A.
McKinzie, D.L., Eha, R., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1996). Evidence
for neuroadaptive changes that occur during abstinence and promote alcohol relapse. Alcoholism:
Clinical and Experimental Research 20: 15A.
McKinzie, D.L., Alexander, D., Eha, R., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K.
(1996). Effects of amphetamine on motor activity in periadolescent alcohol-preferring (P) and nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 20: 23A.
Ikemoto, S., Murphy, J.M., and McBride, W.J. (1996). Activation of GABAA receptors within
mesencephalic raphe nuclei mediates operant reinforcement. Alcoholism: Clinical and Experimental
Research 20: 61A.
Ikemoto, S., Glazier, B.S., Murphy, J.M., and McBride, W.J. (1996). Self-infusion of D1 and D2
agonists into the nucleus accumbens of rats. Society for Neuroscience Abstracts 22:
McKinzie, D.L.,Sajdyk, T.J., Murphy, J.M., McBride, W.J., Lumeng, L., Li, T.-K., and Shekhar, A.
(1996). Startle and fear-potentiated startle responding in the alcohol-preferring ( P) and nonpreferring (NP) rat. Society for Neuroscience Abstracts 22: 2071.
James M. Murphy
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116. June, H.L., Murphy, J.M., Froehlich, J.C., Lewis, M.J., and Lumeng, L. (1996). Characterization of
nalmefene, the 6-methylene derivative of naltrexone on ethanol reinforced behaviors. American
College of Neuropsychopharmacology 35: 164.
117. June, H.L., Murphy, J.M., Matecka, D., Lewis, M.J., and Lumeng, L. (1996). Gabaergic transmission
in the mesoaccumbens is involved in alcohol self-administration in alchol-preferring (P) rats.
American College of Neuropsychopharmacology 35: 224.
118. Goodlett, C.R., McKinzie, D.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1997).
Comparison of morris maze place learning in juvenile rats of the HAD and LAD selected lines.
Alcoholism: Clinical and Experimental Research 21: 17A.
119. McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). The effects of 5-HT3
receptor antagonists on operant responding for ethanol in alchol-preferring (P) rats. Alcoholism:
Clinical and Experimental Research 21: 107A.
120. McKinzie, D.L., Eha, R., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). Effects of
high dose ethanol and the development of tolerance in high alcohol-drinking (HAD) and low alcoholdrinking (LAD) lines of rats. Alcoholism: Clinical and Experimental Research 21:42A.
121. McKinzie, D.L., Cox, R., McBride, W.J., Stewart, R.B., Murphy, J.M., Lumeng, L., and Li, T.-K.
(1997). Sensitivity and rapid tolerance to the sedative effects of penobarbital in alcohol-preferring
(P) and -nonpreferring NP rats. Alcoholism: Clinical and Experimental Research 21: 42A.
122. Nowak, K.L., McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). The
development of alcohol-drinking behavior in single- and pair-housed alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 21: 108A.
123. Nowak, K.L., Brenneman, M.G., Dagon, C.L., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy,
J.M. (1997). Blocking GABA-A receptors in the anterior VTA attenuates ethanol intake of the
alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 21: 74A.
124. Nowak, K.L., McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997).
Patterns of operant responding for and drinking of ethanol and saccharin in P rats using a 2-hr
alternate-day-access schedule. Alcoholism: Clinical and Experimental Research 21:11A.
125. Nowak, K.L., McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997).
Heightened response to novelty in the alcohol-preferring P rat. Alcoholism: Clinical and
Experimental Research 21:15A.
126. Stewart, R.B., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). Sweet preference and spontaneous
motor activity are correlated with alcohol intake in the F2 progeny of an alcohol-preferring (P) and nonpreferring (NP) rat cross. Alcoholism: Clinical and Experimental Research 21: 16A.
127. McKinley, P.J., Meisch, R.A., Murphy, J.M., and Stewart, R.B. (1997). Choice between
concurrently-available oral ethanol doses: Effects of fixed-ratio schedule and body-weight
reduction. Alcoholism: Clinical and Experimental Research 21: 12A.
128. June, H.L., Lewis, M.J., and Murphy, J.M. GABAergic transmission in the meso-accumbens is
involved in ethanol motivated behaviors. Presented at the 41st annual meeting of the Behavioral
Pharmacology Society, Philadelphia, Pennsylvania, May 30-31. 1997.
129. Cason, C.R., June, H.L., Fredericks, M., Cheatham, G., Chen, A., Cook, J., Gan, T., and Murphy,
J.M. (1997) Gabaergic regulation of the reinforcing properties of alcohol in Wistar rats. Society for
Neuroscience Abstracts 23: 959
130. June, H.L., Cheatham, G., Fredericks, M., Cason, C.R., Chen, A., Cook, J., Gan, T., and Murphy,
J.M. (1997) Gabaergic regulation of the sedative properties of alcohol in the striatum of Wistar rats.
Society for Neuroscience Abstracts 23: 958
131. Mckinzie, D.L., Glazier, B.S., Murphy, J.M., Li, T.-K., Lumeng, L., and McBride, W.J. (1997) cocaine
is self-administered into the anterior nucleus accumbens shell region of alcohol-preferring rats.
Society for Neuroscience Abstracts 23: 1105.
132. McKinzie, D.L., Dagon, C.L., McBride, C.L., Murphy, J.M., Lumeng, L., Li, T.-K., and Shekhar, A.
Enhanced disruption of prepulse inhibition in P versus NP rats following low-dose ethanol
administration. Presented at the World congress on Psychiatric Genetics. Santa Fe, New Mexico,
October 19-23, 1997.
133. McKinzie, D.L., Nowak, K.L., Dagon, C.L., Rodd, Z.A., Murphy, J.M., McBride, W.J., Lumeng, L.,
and Li, T.-K. (1998). Behavioral sensitization to repeated cocaine administrations in the alcoholpreferring (P) and alcohol-nonpreferring (NP) rat lines. Alcoholism: Clinical and Experimental
Research 22: 99A.
James M. Murphy
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134. McKinzie, D.L., Dagon, C.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1998). The
effects of acamprosate on ethanol-reinforced responding in the alcohol-preferring (P) rat.
Alcoholism: Clinical and Experimental Research 22: 14A.
135. Nowak, K.L., McKinzie, D.L., Dagon, C.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K.
(1998). Differences in an operant measurement of impulsivity between alcohol-preferring (P) and
alcohol-nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 22: 54A.
136. Nowak, K.L., Crile, R.S., McBride, W.J., Lumeng, L., Li, T.-K. and Murphy, J.M. (1998). Effects of
manipulating dopamine D-2 receptors in the anterior VTA of the alcohol-preferring (P) rat.
Alcoholism: Clinical and Experimental Research 22: 14A.
137. Rodd, Z.A., Nowak, K.L., McKinzie, D.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K.
(1998). Alcohol deprivation effect as a funciton of deprivation length and deprivation exposures in
the alcohol-preferring (P) rat. Alcoholism: Clinical and Experimental Research 22: 15A.
138. Stewart, R.B., McKinley, P.J., Bottoms, D.M., Bottoms, N.A., and Murphy, J.M. (1998). Sensitivity
and tolerance to the motor-impairing effects of ethanol in rats of the selectively bred high alcohol
drinking (HAD) and low alcohol drinking (LAD) lines. Alcoholism: Clinical and Experimental
Research 22: 91A.
139. Stewart, R.B., Murphy, J.M., and McKinley, P.J. (1998). Decreases in ethanol-maintained leverpress responding in rats following naloxone pretreatment: The effects of varying the available
ethanol concentration. Alcoholism: Clinical and Experimental Research 22: 13A.
140. Stewart, R.B., Murphy, J.M., Lumeng, L., and Li, T.-K. (1998). Intake of saccharin solution in
selectively-bred high and low alcohol drinking (HAD and LAD) lines of rats and in the F2 progeny of
HAD and LAD rat crosses. Alcoholism: Clinical and Experimental Research 22: 55A.
141. Engleman, E.A., McBride, W.J., Wilber, A.A., Shaikh, S.R., Eha, R.D., Lumeng, L., Li, T.-K., and
Murphy, J.M. (1998) Reverse microdialysis of dopamine (DA) uptake inhibitors into the nucleus
accumbens (NAc) of alcohol preferring (P) rats: Effects on extracellular DA levels and ethanol
(EtOH) intake. Society for Neuroscience Abstracts 24: 1478.
142. Nowak, K.L., Crile, R.S., McKinzie, D.L., Murphy, J.M. Lumeng, L., and Li, T.-K. Differences in
measures of aggression in alcohol-preferring and non-preferring rat lines.(1998) Society for
Neuroscience Abstracts 24: 748.
143. Rodd, Z.A., McKinzie, D.L., Dagon, C.L., Murphy, J.M. and McBride, W.J. (1998) Intracranial selfadministration of ethanol into the posterior VTA by Wistar rats. Society for Neuroscience Abstracts
24: 1479.
144. McKinzie, D.L., Rodd, Z.A., Dagon, C.L., Murphy, J.M., and McBride, W.J. Cocaine is selfadministered into the shell region of the nucleus accumbens in Wistar rats. Presented at the New
York Academy of Sciences Conference: Advancing from the Ventral Striatuum to the Extended
Amygdala: Implications for Neuropsychiatry and Drug Abuse. October 18-21, 1998 Charlottesville,
VA.
145. Rodd-Henricks, Z.A., McKinzie, D.L., Li, T.-K., Murphy, J.M. and McBride, W.J. Regional
heterogeneity within the rat ventral tegmental area for intracranial self-administration of alcohol.
(1998) Presented at the annual meeting of the American College of Neuropsychopharmacology,
December, 1998, Los Crobas, Puerto Rico.
146. Badia-Elder, N.E., Stewart, R.B., Woods, J.E., II, Powrozek, T.A., Murphy, J.M., Lumeng, L., and Li,
T.-K. (1999) Ethanol-induced conditioned taste aversion in high alcohol drinking (HAD) and low
alcohol drinking (LAD) rats. Alcoholism: Clinical and Experimental Research 23: 104A.
147. Bell, R.L., McKinzie, D.L., Murphy, J.M., and McBride, W.J. (1999) Assessing sensitivity and
tolerance to the motor impairing effects of moderate doses of ethanol. Alcoholism: Clinical and
Experimental Research 23: 98A.
148. Engleman, E.A., McBride, W.J., Wilber, A.A., Shaikh, S.R., Eha, R.D., Lumeng, L., Li, T.-K., and
Murphy, J.M. (1999) Ethanol drinking experience potentiates the increase in extracellular dopamine
(DA) in nucleus accumbens (NAc) with GBR12909 (GBR) in alcohol-preferring (P) rats. Alcoholism:
Clinical and Experimental Research 23: 48A.
149. Goodlett, C. R., McKinzie, D.L., Crile, R.S., Murphy, J.M., Lumeng, L., Li, T.-K ., and McBride, W.J.
(1999) Alcohol induces dose-dependent impairments of spatial navigation learning in adolescent
HAD and LAD rats. Alcoholism: Clinical and Experimental Research 23: 55A.
150. Jones, A.E., Crile, R.S., Murphy, J.M., McBride, W.J., Lumeng, L., Li, T.-K ., and McKinzie, D.L.
(1999) Effects of background noise on habituation to the acoustic startle response in the alcohol
preferring (P) and non-preferring (NP) rat. Alcoholism: Clinical and Experimental Research 23: 98A.
James M. Murphy
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151. Jones, A.E., Dagon, C.T., Murphy, J.M., Lumeng, L., Li, T.-K ., McBride, W.J., Shekhar, A., and
McKinzie, D.L. (1999) Effects of fenfluramine and amphetamine on the startle reflex response in
alcohol preferring (P) and nonpreferring (NP) lines of rats. Alcoholism: Clinical and Experimental
Research 23: 104A.
152. Jones, A.E., Edmundson, V.E., Murphy, J.M., McBride, W.J., Lumeng, L., Li, T.-K ., and McKinzie,
D.L. (1999) Effects of acute ethanol administration on body temperature ih high alcohol drinking
(HAD) and low alcohol drinking (LAD) rats. Alcoholism: Clinical and Experimental Research 23:
99A.
153. McKinzie, D.L., Edmundson, V.E., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K . (1999)
Oral acamprosate effects on ethanol-reinforced responding in the alcohol preferring (P) rat.
Alcoholism: Clinical and Experimental Research 23: 20A.
154. McKinzie, D.L., Edmundson, V.E., Rodd-Henricks, Z.A., Murphy, J.M., McBride, W.J., Lumeng, L.,
and Li, T.-K . (1999) Effects of acute and chronic cocaine on ethanol drinking and body
temperature in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 23:
101A.
155. Nowak, K.L., McBride, W.J., Lumeng, L., Li, T.-K. and Murphy, J.M. (1999). Suppression of alcohol
intake of the alcohol preferring P rat following dorsal raphe injections of 8-OH-DPAT. Alcoholism:
Clinical and Experimental Research 23: 20A.
156. Rock, S., Neal-Belveau, B.S., and Murphy, J.M. (1999) Ethanol and cocaine interactive effect on
local cerebral glucose utilization (LCGU). Alcoholism: Clinical and Experimental Research 23:
101A.
157. Rodd-Henricks, Z.A., McKinzie, D.L., Li, T.-K., Crile, R.S., Murphy, J.M., and McBride, W.J., (1999)
Intracranial self-administration of ethanol into the posterior VTA of Wistar rats is mediated by 5-HT3
receptors. Alcoholism: Clinical and Experimental Research 23: 49A.
158. Rodd-Henricks, Z.A., McKinzie, D.L., Edmundson, V.E., Murphy, J.M., McBride, W.J., Lumeng, L.,
and Li, T.-K. (1999) Serotonin-3 receptor antagonists reduce alcohol intake during acquisition and
maintenance but not following a period of alcohol deprivation in alcohol preferring (P) rats.
Alcoholism: Clinical and Experimental Research 23: 49A.
159. Rodd-Henricks, Z.A., McKinzie, D.L., Shaikh, S.R., Edmundson, V.E., Murphy, J.M., McBride, W.J.,
Lumeng, L., and Li, T.-K. (1999) The alcohol deprivation effect in high alcohol drinking (HAD) rat
lines is dependent upon repeated deprivations. Alcoholism: Clinical and Experimental Research 23:
17A.
160. Stewart, R.B., Badia-Elder, N.E., Powrozek, T.A., Woods, J.E., II, Murphy, J.M., Lumeng, L., and Li,
T.-K. (1999) comparisons of high alcohol drinking (HAD) and low alcohol drinking (LAD) rats on an
elevated plus maze test of anxiety. Alcoholism: Clinical and Experimental Research 23: 105A.
161. Bell, R.L., Jones, A.E., McKinzie, D.L., McBride, W.J., and Murphy, J.M. (1999) Tolerance develops
to the stimulation of heart rate by alcohol. Society for Neuroscience Abstracts, 25:1078
162. Rodd-Henricks, Z.A., McKinzie, D.L., Murphy, J.M., McBride, W.J., Lumeng, L. and Li, T.-K. (1999)
Tolerance develops to the stimulation of heart rate by alcohol. Society for Neuroscience Abstracts,
25:1077
163. Smith, D.G., Learn, J.E., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1999) Local
cerebral glucose utilization in alcohol-preferring P rats. Society for Neuroscience Abstracts, 25:1577
164. Smith, D.G., Learn, J.E., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1999) Local
cerebral glucose utilization in alcohol-deprived and alcohol non-deprived alcohol-preferring P rats.
Presented at the workshop meeting of the Indiana Alcohol Research Center and National Institute
of Alcohol Abuse and Alcoholism meeting AAlcoholism: What Can Research Offer in the 21st
Century@, Indianapolis, IN, December 8-9, 1999.
165. Badia-Elder, N.E., Stewart, R.B., Powrozek, T.A., Murphy, J.M., and Li, T.-K. (2000) Effects of
neuropeptide Y (NPY) on ethanol intake and anxiety in high and low alcohol drinking (HAD/LAD)
rats. Alcoholism: Clinical and Experimental Research 24: 82A.
166. Badia-Elder, N.E., Stewart, R.B., Powrozek, T.A., Roy, K.F., Murphy, J.M., and Li, T.-K. (2000)
Effect of neuropeptide Y (NPY) on ethanol intake in Wistar, alcohol-preferring (P), and nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 24: 82A.
167. Bell, R.L., Stewart, R.B., Woods, J.E., Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J.
(2000) Alcohol-preferring (P) and -nonpreferring (NP) rats differ in motor impairment after moderate
doses of alcohol. Alcoholism: Clinical and Experimental Research 24: 88A
James M. Murphy
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168. Bell, R.L., Rodd-Henricks, Z.A., Kelly, K.R., Webster, A.A., Lumeng, L., Li, T.-K., McBride, W.J.,
and Murphy, J.M. (2000) Alcohol drinking stimulates heart rate in alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 24: 49A.
169. Engleman, E.A., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2000) Ethanol drinking
experience attentuates (-)sulpiride-induced increases in extracellular dopamine (DA) levels in
nucleus accumbens (NAc) of alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental
Research 24: 85A
170. Jones, A.E., Bell, R.L., Crile, R.S., McKinzie, D.L., Murphy, J.M., Lumeng, L., Li, T.-K., and
McBride, W.M. (2000) Effects of ethanol on startle responding and prepulse inhibition in adolescent
high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Alcoholism: Clinical and
Experimental Research 24: 94A.
171. Melendez, R.I., Engleman, E., Bell, R.L., Schmitz, C., McBride, W.J., Li, T.-K., and Murphy, J.M.
(2000) Behavioral activity of alcohol-preferring (P) rats during anticipation and operant responding
for oral reinforcers. Alcoholism: Clinical and Experimental Research 24: 51A
172. Nowak, K.L., Sajdyk, T.J., Ingraham, C.M., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M.
(2000) Alcohol intake of the alcohol-preferring P rat is decreased by microinjections of neuropeptide
Y into the basolateral amygdala. Alcoholism: Clinical and Experimental Research 24: 82A.
173. Nowak, K.L., Thielen, R.J., Ingraham, C.M., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M.
(2000) Microinjections of 8-OH-DPAT into the dorsal raphe increase alcohol intake of the alcoholnonpreferring NP rat. Alcoholism: Clinical and Experimental Research 24: 86A.
174. Powrozek, T.A., Badia-Elder, N.E., Murphy, J.M., and Stewart, R.B. (2000) Negative contrast effect
in rats following a shift from a high to a low ethanol concentration. Alcoholism: Clinical and
Experimental Research 24: 53A.
175. Rodd-Henricks, Z.A., Bell, R.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2000)
Repeated deprivations enhance the reinforcing properties of ethanol in alcohol preferring (P) rats.
Alcoholism: Clinical and Experimental Research 24: S17:5
176. Rodd-Henricks, Z.A., Jones, A.R., Webster, A.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li,
T.-K. (2000) Repeated deprivations shift preference for higher ethanol concentrations and enhance
the magnitude and duration of the alcohol deprivation effect in the alcohol preferring (P) rat.
Alcoholism: Clinical and Experimental Research 24: 14A.
177. Rodd-Henricks, Z.A., Bell, R.L., Webster, A.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li,
T.-K. (2000) Low-dose ethanol stimulates locomotor activity in alcohol preferring adolescent rats.
Alcoholism: Clinical and Experimental Research 24: 57A
178. Rodd-Henricks, Z.A., Bell, R.L., Melendez, R.I., Jones, A.R., Murphy, J.M., McBride, W.J., Lumeng,
L., and Li, T.-K. (2000) Repeated deprivations enhance operant alcohol self-administration in the
alcohol preferring (P) rat. Alcoholism: Clinical and Experimental Research 24: 52A.
179. Smith, D.G., Learn, J.E., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2000) Changes in
local cerebral glucose utilization following alcohol-relapse drinking in alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 24: 53A.
180. Stewart, R.B., Roy, K.F., Badia-Elder, N.E., Li, T.-K., and Murphy, J.M. (2000) Sucrose intake
following chronic oral ethanol self-administration in high alcohol drinking HAD rats. Alcoholism:
Clinical and Experimental Research 24: 53A.
181. Stewart, R.B., Woods, J.E., II, Lumeng, L., Murphy, J.M., and Li, T.-K. (2000) Tolerance to the
motor-impairing effects of ethanol: Comparison of replicate lines of high alcohol drinking (HAD) and
low alcohol drinking (LAD) rats. Alcoholism: Clinical and Experimental Research 24: 89A.
182. Thielen, R.J., Nowak, K.L., Ingraham, C.M., Bell, R.L., McBride, W.J., Murphy, J.M., Lumeng, L.,
and Li, T.-K. (2000) Assessment of postsynaptic 5-HT1A receptor function in wistar, P and NP rats
using 8-OH-DPAT-induced hypothermia. Alcoholism: Clinical and Experimental Research 24: 94A.
183. Stewart, R., Bell, R., Murphy, J., McBride, W., Lumeng L., and Li, T.-K. Ethanol tolerance in lines of
rats selectively bred for oral ethanol preference. Presented at the 10th Congress of the International
Society for Biomedical Research on Alcoholism, Yokohama, Japan, July2-8, 2000.
184. Rodd-Henricks, Z.A., Bell, R.L., Murphy, J.M. and McBride, W.J. (2000) Intracranial selfadministration of cocaine into the posterior ventral tegmental area of rats. Society for Neuroscience
Abstracts 26: 1833.
185. Bell, R.L., Rodd-Henricks, Z.A., Webster, A.A., Lumeng, L., Li, T.-K., McBride, W.J., and Murphy,
J.M. (2000) Alcohol drinking alters activity in alcohol-preferring rats. Society for Neuroscience
Abstracts 26: 1818.
James M. Murphy
32
186. Engleman, E.A., McBride, W.J., Li, T.-K., Lumeng, L., and Murphy, J.M. (2000) Microinjection of
ethanol (EtOH) into the ventral tegmental area (VTA) produces conditioned place aversion in
alcohol-preferring rats. Society for Neuroscience Abstracts 26: 1818.
187. Melendez, R.I., Engleman, E., Schmitz, C., McBride, W.J., Li, T.-K., and Murphy, J.M. (2000)
Extracellular levels of dopamine (DA) in the nucleus accumbens of alcohol-preferring rats during
anticipation and operant responding for oral reinforcers. Society for Neuroscience Abstracts 26:
1818.
188. Badia-Elder, N.E., Stewart, R.B., Roy, K.F., Kennedy, M.J., Murphy, J.M., and Li, T.-K. (2001)
Effects of microinfusions of neuropeptide Y (NPY) into the central nucleus of the amygdala (CeA)
on ethanol intake in high alcohol drinking HAD1 rats. Alcoholism: Clinical and Experimental
Research 25: 15A.
189. Badia-Elder, N.E., Stewart, R.B., Roy, K.F., Kennedy, M.J., Murphy, J.M., and Li, T.-K. (2001)
Effects of neuropeptide Y (NPY) on ethanol-induced sleep time in alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 25: 15A.
190. Bell, R.L., Rodd-Henricks, Z.A., Kuc, K.A., Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J.
(2001) Alcohol consumption during periadolescence in alcohol-preferring (P) rats using a single or
multiple concentrations of ethanol. Alcoholism: Clinical and Experimental Research 25: 20A
191. Bell, R.L., Rodd-Henricks, Z.A., Hsu, K.A., Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J.
(2001) Alcohol consumption during periadolescence in high alcohol drinking (HAD) rats using a
single or multiple concentrations of ethanol. Alcoholism: Clinical and Experimental Research 25:
20A
192. Rodd-Henricks, Z.A., Bell, R.L., Kuc, K.A., Melendez, R.I., Murphy, J.M., McBride, W.J., Lumeng,
L., and Li, T.-K. (2001) Access to multiple ethanol concentrations by high alcohol-drinking (HAD)
rats contribute to the expression of a robust alcohol deprivation effect (ADE) which is enhanced
with repeated deprivations. Alcoholism: Clinical and Experimental Research 25: 20A
193. Melendez, R.I., Rodd-Henricks, Z.A., Kuc, K.A., McBride, W.J., and Murphy, J.M. (2001) Regulation
of ethanol reinforcement in the posterior ventral tegmental area by dopamine neurons. Alcoholism:
Clinical and Experimental Research 25: 60A
194. Roy, K.F., Kennedy, M.J. Badia-Elder, N.E., Murphy, J.M., Neal-Beliveau, B., and Stewart, R.B.
(2001) Effects of chronic amphetamine on motor activity and responding maintained by oral ethanol
in rats. Alcoholism: Clinical and Experimental Research 25: 62A.
195. Bell, R.L., Rodd-Henricks, Z.A., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K.
(2001) Effects of periadolescent ethanol drinking on oral ethanol self-administration by adult
alcohol-preferring (P) rats. I. Acquisition and extinction. Alcoholism: Clinical and Experimental
Research 25: 63A
196. Rodd-Henricks, Z.A., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K.
(2001) Effects of periadolescent ethanol drinking on oral ethanol self-administration by adult
alcohol-preferring (P) rats. II. Spontaneous recovery. Alcoholism: Clinical and Experimental
Research 25: 63A
197. Engleman, E.A., Bell, R.L., Rodd-Henricks, Z.A., Ingraham, C.M., McBride, W.J., Li, T.-K.,
Lumeng, L., and Murphy, J.M. (2001) Conditioned place preference with morphine in alcoholpreferring (P) and Wistar rats. Alcoholism: Clinical and Experimental Research 25: 64A
198. Bell, R.L., Rodd-Henricks, Z.A., Hsu, C.C., Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J.
(2001) Effects of amphetamine on the acoustic startle response of alcohol-preferring (P) and
-nonpreferring (NP) rats. Society for Neuroscience Abstracts 27, Program no. 444.11.
199. Engleman, E.A., Thielen, R.J., O’Brien, C.E., Jones, A.R., McBride, W.J.,Lumeng, L., Li, T.-K., and
Murphy, J.M. (2001) Effects of ethanol drinking experience on dopamine D2 autoreceptor function
in the nucleus accumbens of alcohol-preferring (P) rats. Society for Neuroscience Abstracts 27,
Program no. 981.8.
200. Melendez, R.I., Rodd-Henricks, Z.A., Zhang, Y., McBride, W.J., and Murphy, J.M. (2001) Systemic
ethanol injection increases extracellular dopamine in the ventral pallidum but not globus pallidus.
Society for Neuroscience Abstracts 27, Program no. 540.6.
201. Rodd-Henricks, Z.A., Bell, R.L., Melendez, R.I., Kuc, K.A., Murphy, J.M., McBride, W.J. (2001)
Interaction between the reinforcing effects of cocaine and ethanol in the posterior ventral tegmental
area of rats. Society for Neuroscience Abstracts 27, Program no. 981.16.
James M. Murphy
33
202. Smith, D.G., Learn, J.E., McBride, W.J., Li, T.-K., Lumeng, L., and Murphy, J.M. (2001) Effects of
relapse drinking on CNS functional activity of alcohol-preferring (P) rats. Society for Neuroscience
Abstracts 27, Program no. 444.8
203. Engleman, E.A., Bell, R.L., Rodd-Henricks, Z.A., Ingraham, C.A., McBride, W.J., Li, T.-K., Lumeng,
L., and Murphy, J.M. (2002) Consummatory and naltrexone-induced withdrawal behaviors after
chronic morphine in P and NP rats. Alcoholism: Clinical and Experimental Research 26: 21A
204. Bell, R.L., Rodd-Henricks, Z.A., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K.,
(2002) Binge drinking induces excessive alcohol intake in the alcohol-preferring P rat. Alcoholism:
Clinical and Experimental Research 26: 61A
205. Bell, R.L., Rodd-Henricks, Z.A., Hsu, C.C., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.J.
(2002) Expression of an alcohol deprivation effect by alcohol non-preferring (NP) rats given
concurrent access to multiple concentrations of ethanol. Alcoholism: Clinical and Experimental
Research 26: 61A
206. Rodd-Henricks, Z.A., Fontinella, C.V., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng,
L., and Li, T.-K. (2002) Effects of concurrent access to and deprivation of ethanol and saccharin on
the expression of a deprivation effect in alcohol-preferring (P) rats. Alcoholism: Clinical and
Experimental Research 26: 61A
207. Rodd-Henricks, Z.A., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K.
(2002) Effects of ethanol drinking during adulthood on operant ethanol self-administration in
alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 26: 62A
208. Rodd-Henricks, Z.A., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K.
(2002) A robust alcohol deprivation effect is expressed by alcohol preferring (P) rats following a
brief initial exposure period. Alcoholism: Clinical and Experimental Research 26: 62A
209. Rodd-Henricks, Z.A., Sable, H.J.K., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L.,
and Li, T.-K. (2002) Repeated alcohol deprivations retard extinction responding and enhance
Pavlovian spontaneous responding by alcohol-preferring (P) rats. Alcoholism: Clinical and
Experimental Research 26: 62A
210. Elder, R.L., Stewart, R.B., Carroll, M.R., Badia-Elder, N.E., and Murphy, J.M. (2002) Differences to
response in restraint stress in high alcohol drinking (HAD1) and low alcohol drinking (LAD1) rats in
an elevated plus maze test of anxiety. Alcoholism: Clinical and Experimental Research 26: 97A
211. Stewart, R.B., Badia-Elder, N.E., Elder, R.L., Murphy, J.M., Lumeng, L., and Li, T.-K. (2002) Acute
tolerance to the motor-impairing effects of ethanol in selectively-bred replicate high alcohol drinking
(HAD1, HAD2) and low alcohol drinking (LAD1, LAD2) lines. Alcoholism: Clinical and Experimental
Research 26: 97A
212. Badia-Elder, N.E., Stewart, R.B., Gilpin, N.W., Elder, R.L., Murphy, J.M., and Li, T.-K. (2002)
Effects of neuropeptide Y (NPY) on ethanol-induced sleep time in alcohol-preferring (P) and –
nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 26: 99A
213. Melendez, R.I., Rodd-Henricks, Z.A., Pommer, T., Li, T.-K., McBride, W.J., and Murphy, J.M. (2002)
Effects of dopamine D2 receptor inhibition in the ventral pallidum of the alcohol-preferring (P) rat on
ethanol intake and extracellular levels of dopamine. Alcoholism: Clinical and Experimental
Research 26: 111A
214. Rodd-Henricks, Z.A., Melendez, R.I., Kuc, K.A., Bell, R.L., McBride, W.J., Li, T.-K. and Murphy,
J.M., (2002) Inhibition of 5-HT3 receptors within the posterior VTA retards the acquisition of operant
self-administration of ethanol by alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental
Research 26: 112A
215. Melendez, R.I., Rodd-Henricks, Z.A., Li, T.-K. McBride, W.J., and Murphy J.M. Dopamine efflux in
the ventral pallidum of alcohol- preferring (P) rats during anticipation and operant self –
administration of ethanol Program No. 289.10. 2002 Abstract Viewer/Itinerary Planner. Washington,
DC: Society for Neuroscience, 2002.
216. Engleman, E.A., Thielen, R.J., O'Brien, C.E., Hill, T.E., Lumeng, L.,.Li, T.-K, McBride, W.J., and
Murphy, J.M.. Chronic ethanol drinking and prolonged or repeated deprivations reduce dopamine
(DA) transmission in the nucleus accumbens (ACB) Program No. 309.1. 2002 Abstract
Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002.
217. Sable, H.J.K., Rodd-Henricks, Z.A.,.Bell, R.L, Zhang, Y.,.Lumeng, L, McBride, W.J., Li, T.-K., and
Murphy, J.M.. Intracranial self-administration of ethanol into the nucleus accumbens shell by
alcohol preferring (P) rats. Program No. 309.6. 2002 Abstract Viewer/Itinerary Planner.
Washington, DC: Society for Neuroscience, 2002.
James M. Murphy
34
218. Bell, R.L., Rodd-Henricks, Z.A., Hsu, C.C., Lumeng L., Li, T.-K., Murphy, J.M., and McBride, W.J.
Acoustic startle response after long-term consumption of ethanol in alcohol-nonpreferring (NP) rats.
Program No. 783.3. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for
Neuroscience, 2002.
219. Bell, R.L., Rodd-Henricks, Z.A., Boutwell, C.L., Hsu, C.C., Chernet, K.R., Murphy, J.M., Lumeng L.,
Li, T.-K., and McBride, W.J.. Effects of repeated deprivations on ethanol drinking by adolescent and
adult alcohol-preferring P and –nonpreferring NP rats. International Society for Developmental
Psychobiology, Orlando FL 2002.
220. Bell, R.L., Rodd, Z.A., Boutwell, C.L., Murphy, J.M., Lumeng L., Li, T.-K., and McBride, W.J. (2003)
Expression of an alcohol deprivation effect (ADE) by low alcohol drinking (LAD) rats given
concurrent access to multiple concentrations of alcohol. Alcoholism: Clinical and Experimental
Research 27: 16A.
221. Bell, R.L., Rodd, Z.A., Schultz, J.A., Murphy, J.M., Lumeng L., Li, T.-K., and McBride, W.J. (2003)
Expression of an alcohol deprivation effect by high alcohol drinking (HAD) rats given binge-like
access to multiple concentrations of alcohol. Alcoholism: Clinical and Experimental Research 27:
16A.
222. Bell, R.L., Rodd, Z.A., Murphy, J.M., and McBride, W.J. (2003) Environmental modulation of
genetically-predisposed ethanol consumption in rats. Alcoholism: Clinical and Experimental
Research 27: 16A.
223. Bell, R.L., Rodd, Z.A., Hsu.C.C., Murphy, J.M., Lumeng L., Li, T.-K., and McBride, W.J. (2003)
Expression of an alcohol deprivation effect by alcohol nonpreferring (NP) rats given access to a
single concentration of ethanol. Alcoholism: Clinical and Experimental Research 27: 16A.
224. Bell, R.L., Rodd, Z.A., Schultz, J.A., Murphy, J.M., Lumeng L., Li, T.-K., and McBride, W.J. (2003)
Naltrexone disrupts acauisition of ethanol intake in female peri-adolescent alcohol-preferring (P)
rats. Alcoholism: Clinical and Experimental Research 27: 17A.
225. Pommer, T.J., Rodd, Z.A., Bell, R.L., McQueen, V.K., Toalston, J.E., Engleman, E.A., Lumeng L.,
McBride, W.J., Li, T.-K., and Murphy, J.M. (2003) Effects of 5-HT3 antagonists within the nucleus
accumbens shell on operant self-administration of ethanol by inbred alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 27: 61A.
226. Rodd, Z.A., Bell, R.L., Pommer, T.J., McQueen, V.K., Li, T.-K., Lumeng L., McBride, W.J., and
Murphy, J.M. (2003) Effects of 5-HT3 antagonists within the posterior VTA on operant selfadministration of ethanol by alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental
Research 27: 61A.
227. Engleman, E.A., Ingraham, C.M., O’Brien, C.E., McBride, W.J., and Murphy, J.M. (2003) Systemic
ethanol administration fails to alter extracellular dopamine levels in the medial prefrontal cortex.
Alcoholism: Clinical and Experimental Research 27: 92A.
228. Toalston, J.E., Rodd, Z.A., Melendez, R.I., Engleman, E.A., Lumeng L., McBride, W.J., and
Murphy, J.M. (2003) Local perfusion of the D1 anatgonist (SCH-23390) increases extracellular
dopamine (DA) levels in the ventral pallidum (VP) of Wistar and alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 27: 92A.
229. Welchel, S.A., Kho, Y., Elder, R.L., Gilpin, N.W., Stewart, R.B., Murphy, J.M., Li, T.-K., and BadiaElder, N.E. (2003) Neuropeptide Y and ethanol produce an additive suppression of motor activity in
alcohol-preferring (P) and non-alcohol-preferring (NP) rats. Alcoholism: Clinical and Experimental
Research 27: 126A.
230. Gilpin, N.W., Stewart, R.B., Murphy, J.M., Li, T.-K., and Badia-Elder, N.E. (2003) Effects of
microinfusions of neuropeptide Y into the central nucleus of the amygdala (CeA) on ethanol intake
in high alcohol drinking (HAD1) and low alcohol drinking (LAD1) rats. Alcoholism: Clinical and
Experimental Research 27: 126A.
231. Gilpin, N.W., Stewart, R.B., Welchel, S.A., Murphy, J.M., Li, T.-K., and Badia-Elder, N.E. (2003)
The effects neuropeptide Y on oral ethanol intake in high alcohol drinking (HAD1) rats following
multiple periods of imposed ethanol abstinence. Alcoholism: Clinical and Experimental Research
27: 127A.
232. Gilpin, N.W., Stewart, R.B., Murphy, J.M., Li, T.-K., and Badia-Elder, N.E. (2003) Neuropeptide Y
reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol
abstinence. Alcoholism: Clinical and Experimental Research 27: 127A.
James M. Murphy
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233. Rodd, Z.A., Bell, R.L., McQueen, V.K., Pommer, T.J., Lumeng L., Li, T.-K., Murphy, J.M., and
McBride, W.J. (2003) 5-HT3 receptors in the ventral tegmental area regulate alcohol drinking and
the reinforcing effects of alcohol. Alcoholism: Clinical and Experimental Research 27: 167A.
234. Rodd, Z.A., Bell, R.L., Sable, H.J., Pommer, T.J., McQueen, V.K., Lumeng, L.,.Murphy, J.M., and
McBride, W.J. Naltrexone reduces two measures of alcohol craving in inbred alcohol - preferring
(iP) rats. Program No 665.11. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for
Neuroscience, 2003.
235. Engleman, E.A., Ingraham, C.M., O'Brien, C.E., McBride, W.J., and Murphy, J.M. Effect of housing
conditions on sulpiride - induced increases in extracellular dopamine levels in the nucleus
accumbens of alcohol - preferring ( P ) rats. Program No 793.11. 2003 Abstract Viewer/Itinerary
Planner. Washington, DC: Society for Neuroscience, 2003.
236. Bell, R.L., Rodd, Z.A., Boutwel, C.L., Hsu, C.C., Lumeng, L., Li, T.-K., Murphy, J.M. and
McBride, W.J. Acoustic startle response (ASR) and prepulse inhibition (PPI) after long-term
consumption of ethanol in low alcohol-drinking (LAD) rats. Program No 853.10. 2003 Abstract
Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003.
237. Engleman, E.A., Ingraham, C.M., McBride, W.J., and Murphy, J.M. (2004) Extracellular dopamine
levels are lower in the medial prefrontal cortex alcohol-preferring (P) rats. Alcoholism: Clinical and
Experimental Research 28: 11A.
238. Carroll, M.E., Engleman, E.A., Murphy, J.M., and Simon, J.R. (2004) Dopamine and serotonin
uptake in the nucleus accumbens, striatum and hippocampus of naive high alcohol drinking (HAD2) and low alcohol drinking (LAD-2) rats. Alcoholism: Clinical and Experimental Research 28: 11A.
239. Pommer, T.J., Rodd, Z.A., Bell, R.L., McQueen, V.K., Kostrzewa, A.L., Lumeng, L., McBride, W.J.,
and Murphy, J.M. (2004) The ventral tegmental area and nucleus accumbens express regional
heterogeneity to the effects of 5-HT3 antagonists on operant ethanol self-administration in alcoholpreferring (P) rats. Alcoholism: Clinical and Experimental Research 28: 12A.
240. Rodd, Z.A., Bell, R.L., Zhang, Y., Gryszowka, V.E., Lumeng, L., Murphy, J.M. and McBride, W.J.
(2004) Stimulating 5-HT3 receptors in the posterior ventral tegmental area (VTA) of alcohol
preferring (P) rats is reinforcing. Alcoholism: Clinical and Experimental Research 28: 12A.
241. Gilpin, N.W., Stewart, R.B., Murphy, J.M., and Badia-Elder, N.E. (2004) Dose-dependent effects of
neuropeptide Y (NPY) on ethanol intake in alcohol-preferring (P) rats following multiple periods of
imposed ethanol abstinence. Alcoholism: Clinical and Experimental Research 28: 54A.
242. Gilpin, N.W., Stewart, R.B., Murphy, J.M., and Badia-Elder, N.E. (2004) Decreased autonomic and
behavioral sensitivity to naloxone during long-term abstinence following chronic daily ethanol and
withdrawal. Alcoholism: Clinical and Experimental Research 28: 55A.
243. Stewart, R.B., Badia-Elder, N.E., Stogsdill, T.R., Loholdt, J.M., Smith, R.J., Murphy, J.M. and
Lumeng, L. (2004) Behavioral phenotyping of inbred alcohol preferring and nonpreferring (IP, INP)
rat strains. Alcoholism: Clinical and Experimental Research 28: 89A.
244. Stewart, R.B., Elder, R.L., Badia-Elder, N.E., Smith, R.J., Murphy, J.M. and Gilpin, N.W. (2004)
Scheduled-induced ethanol drinking in alchol-preferring and –nonpreferring (P,NP) and replicate
high and low drinking (HAD1/LAD1, HAD2/LAD2) lines of rats. Alcoholism: Clinical and
Experimental Research 28: 89A.
245. Rodd, Z.A., Bell, R.L., Strother, W.N., Sable, H.J.K., Aloor, H., McClintick, J.N., Stephens, M.,
Jerome, R., Liu, W.M., Lumeng, L., Murphy, J.M., Edenberg, H.J. and McBride, W.J. (2004) Selfinfusion of ethanol into the posterior ventral tegmental area (VTA) alters gene expression in VTA
projection areas. Alcoholism: Clinical and Experimental Research 28: 89A
246. Bell, R.L., Rodd, Z.A., Schultz, J.A., Hsu, C.C., Lumeng, L., Li, T.-K., Murphy, J.M. and McBride,
W.J. (2004) Pattern of ethanol drinking by peri-adolescent alcohol-preferring (P) rats. Alcoholism:
Clinical and Experimental Research 28: 95A.
247. Sable, H.J.K., Bell, R.L., Rodd, Z.A., Schultz, J.A., Murphy, J.M. and McBride, W.J. (2004) Effects
of naltrexone on the acquisition of ethanol intake in adolescent and adult alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 28: 95A.
248. Rodd, Z.A., Bell, R.L., Kuc, K.A., Gryszowka, V.E., Lumeng, L., Murphy, J.M. and McBride, W.J.
(2004) Alcohol-preferring (P) rats are more sensitive than Wistar rats to the reinforcing effects of
cocaine in the nucleus accumbens shell. Alcoholism: Clinical and Experimental Research 28: 97A.
249. Bell, R.L., Rodd, Z.A., Boutwell, C.L., Lumeng, L., Li, T.-K., McBride, W.J. and Murphy, J.M. (2004)
A conditioned heart rate response during deprivation in ethanol-experienced alcohol-preferring (P)
rats. Alcoholism: Clinical and Experimental Research 28: 98A.
James M. Murphy
36
250. Bell, R.L., Rodd, Z.A., Boutwell, C.L., Stewart, R.B., Badia-Elder, N.E., Murphy, J.M. and McBride,
W.J. (2004) Ethanol odor alters prepulse inhibition, but not acoustic startle responding, in ethanolexperience adult P rats. Alcoholism: Clinical and Experimental Research 28: 98A.
251. Rodd, Z.A., McKinzie, D.L., Bell, R.L., Sable, H.J.K., Lumeng, L., Murphy, J.M., Schoepp, D.D. and
McBride, W.J. (2004) LY404039, a metabotropic glutamate 2/3 agonist, reduces alcohol craving in
alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 28:134A.
252. Bell, R.L., Rodd, Z.A., Boutwell, C.L., Murphy, J.M. Lumeng, L., Li, T.-K. and McBride, W.J. (2004)
Repeated daily scheduled access results in binge-like ethanol consumption in adult inbred P rats.
Alcoholism: Clinical and Experimental Research 28: 143A.
253. Bell, R.L., Rodd, Z.A., Sahr, A.E., Murphy, J.M. and McBride, W.J. (2004) Ethanol consumption
during adolescence and its long-term consequences. Alcoholism: Clinical and Experimental
Research 28: 175A.
254. Rodd, Z.A., Bell, R.L., Lumeng, L., Li, T.-K., Murphy, J.M., Edenberg, H.J. and McBride, W.J.
(2004) Gene expression in limbic regions following ethanol eslf-infusion into the posterior ventral
tegmental area (VTA). Alcoholism: Clinical and Experimental Research 28: 183A.
255. Oster S.M., Thielen R.J.,.Engleman E.A, Ingraham C.M.,.Moran A.D, Marunde R.L., Lumeng
L.,.Murphy J.M, McBride W.J. Effects of amount of ethanol drinking on extracellular levels of
serotonin in the nucleus accumbens of P rats. Program No 117.12. 2004 Abstract Viewer/Itinerary
Planner. Washington, DC: Society for Neuroscience, 2004.
256. Kostrzewa A.L., Rodd Z.A., Bell R.L., Murphy J.M., McBride W.J. Nicotine is self-administered into
the posterior ventral tegmental area of Wistar rats. Program No 121.10. 2004 Abstract
Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004.
257. Rodd Z.A,.Bell R.L, McQueen V.K., Davids M.R., Hsu C.C., Lumeng L., Murphy J.M., McBride W.J.
Exposure to repeated deprivation cycles results in prolonged alterations in the sensitivity to the
reinforcing effects of alcohol within the posterior VTA in alcohol-preferring (P) rats. Program No
489.1. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004.
258. Bell R.L, Rodd Z.A., Sable H.J.K., McQueen V.K., Davids M.R., Murphy J.M., Lumeng L., McBride
W.J. Cannabinoid CB1 antagonist reduces alcohol intake during acquisition, maintenance, and
relapse in inbred alcohol preferring (IP) rats. Program No 489.6. 2004 Abstract Viewer/Itinerary
Planner. Washington, DC: Society for Neuroscience, 2004.
259. Gryszowka V.E., Rodd Z.A., Bell R.L., Lumeng L., Murphy J.M., McBride W.J. The reinforcing
properties of 5-HT3 receptors in the ventral tegmental area (VTA): Evidence for regional
heterogeneity and genetic influence. Program No 580.6. 2004 Abstract Viewer/Itinerary Planner.
Washington, DC: Society for Neuroscience, 2004.
260. Oster SM, Rodd ZA, McQueen VK, Bell RL, Lumeng L, McBride WJ, Murphy JM. The CB1 agonist,
CP 55,940, increased ethanol consumption during acquisition in high alcohol-drinking (HAD-2) rats.
Alcoholism: Clinical and Experimental Research 29: 12A, 2005
261. Toalston JE, Rodd ZA, Davids MR, Bell RL, Engleman EA, Murphy JM, McBride WJ.
Microinjections of ethanol into the posterior, but not anterior, ventral tegmental area (VTA) increase
dopamine release in the nucleus accumbens. Alcoholism: Clinical and Experimental Research 29:
13A, 2005.
262. Rodd ZA, McKinzie DL, Bell RL, Pommer TJ, Lumeng L, Murphy JM, Schoepp DD, McBride WJ.
LY255582 reduces alcohol seeking, relapse drinking, and maintenance drinking in alcoholpreferring (P) rats. Alcoholism: Clinical and Experimental Research 29: 18A, 2005.
263. Rodd ZA, Bell RL, Pommer TJ, McQueen VK, Lumeng L, Murphy JM, McKinzie DL, McBride WJ.
The CB1 antagonist SR141716 transiently reduces operant ethanol self-administration during
relapse drinking and maintenance, and inhibits alcohol seeking alcohol-preferring (P) rats.
Alcoholism: Clinical and Experimental Research 29: 19A, 2005.
264. Bell RL, Rodd ZA, Schultz JA, Troy KM, Lumeng L, Murphy JM, McBride WJ. Pattern of ethanol
drinking by adolescent and adult high alcohol drinking (HAD-2) rats. Alcoholism: Clinical and
Experimental Research 29: 19A, 2005.
265. Franklin KM, Engleman EA, Ingraham CM, McBride WJ, Murphy JM. Effects of single and repeated
ethanol injections on D2 autoreceptor function in the nucleus accumbens (NACC) of Wistar rats.
Alcoholism: Clinical and Experimental Research 29: 93A, 2005.
James M. Murphy
37
266. Bell RL, Rodd ZA, Sable HJK, McKinzie DL, McQueen VK, Schultz JA, Murphy JM, Lumeng L,
McBride WJ. Assessing the role of the opioid system as a pharmacotherapeutic target in the
treatment of alcoholism: Old and new. Alcoholism: Clinical and Experimental Research 29: 187A,
2005.
267. McKinzie DL, Rodd ZA, Bell RL, Murphy JM, Schoepp DD, McBride WJ. Promising novel
pharmacotherapeutics in the treatment of alcoholism: What’s around the corner? Alcoholism:
Clinical and Experimental Research 29: 188A, 2005.
268. Oster SM, Rodd Z.A, Toalston JE, Murphy JM, Bell RL, McBride WJ. Ethanol self -administration
into the posterior ventral tegmental area is not mediated by GABAA receptors. Program Number:
680.20, 2006 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.
269. Toalston JE, Rodd Z.A, Oster SM, Murphy JM, Bell RL, McBride WJ. Activating serotonin -3
receptors in the posterior ventral tegmental area is reinforcing and requires stimulation of dopamine
neurons. Program Number: 227.12, 2006 Abstract Viewer/Itinerary Planner. Washington, DC:
Society for Neuroscience.
270. Rodd ZA, Toalston JE, Davids MR, Bell RL, Engleman, EA, Murphy JM, and McBride WJ.
Microinjections of acetaldehyde into the posterior ventral tegmental area (VTA) increases dopamine
release in the nucleus accumbens. Alcoholism: Clinical and Experimental Research 30: 132A,
2006.
271. Rodd ZA, Toalston JE, Davids MR, Bell RL, Engleman, EA, Murphy JM, and McBride WJ. Chronic
alcohol drinking alters the sensitivity of dopamine (DA) neurons in the posterior ventral tegmental
area (VTA) to the local activating effects of ethanol. Alcoholism: Clinical and Experimental
Research 30: 133A, 2006.
272. Carroll MR, Rodd ZA, McBride WJ, Murphy JM, and Simon JR. Chronic EtOH consumption
increases DA uptake in the ACb of female HAD-1 rats. Alcoholism: Clinical and Experimental
Research 30: 181A, 2006.
273. Toalston JE, Rodd Z.A, Oster SM, Murphy JM, Bell RL, McBride WJ. Effects of peri-adolescent
ethanol drinking on oral saccharin self-administration by adult alcohol preferring (P) rats.
Alcoholism: Clinical and Experimental Research 30: 187A, 2006.
274. Engleman EA, Thielen RJ, Rodd ZA, Murphy JM and McBride WJ. Neurochemical measures of
neuroadaptations of the ventral tegmental area – nucleus accumbens dopamine system after
chronic alcohol drinking. Alcoholism: Clinical and Experimental Research 30: 246A, 2006.
275. Bell RL, Rodd ZA, Kimpel MW, Strother WN, Jerome R, McClintick JN, Murphy JM, Lumeng L,
Edenberg HJ, McBride WJ. Repeated scheduled drinking-in-the-dark (DID) access to ethanol and
its effects on gene expression in adult inbred P rats. Alcoholism: Clinical and Experimental
Research 30: 265A, 2006.
276. Bell RL, Rodd ZA, Larson LA, Toalston JE, Cook JB, Oster SM, Lumeng L, McBride WJ, Murphy
JM. Peri-adolescent ethanol exposure reduces basal heart rate but not autonomic reactivity to selfadministered ethanol in adult P rats Alcoholism: Clinical and Experimental Research 31: 21A.
Presented at the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11,
2007.
277. Bell RL, Rodd ZA, Schultz JA, Toalston JE, Oster SM, Murphy JM, Lumeng L, McBride WJ. An
evaluation of the consummatory behavior of genetically selected alcohol-preferring rats during
adolescence and adulthood. Alcoholism: Clinical and Experimental Research 31: 23A. Presented at
the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007
278. Toalston JE, Rodd ZA, Oster SM, Murphy JM, Bell RL, McBride WJ. Effects of saccharin or ethanol
drinking by alcohol-preferring (P) rats during peri-adolescence on EtOH self-administration during
adulthood. Alcoholism: Clinical and Experimental Research 31: 73A. Presented at the 30th annual
meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007
279. Oster SM, Pommer TJ, Toalston JE, Murphy JM, Bell RL, McBride WJ, Rodd ZA. Exposure to
multiple concentrations of ethanol under operant oral self-administration conditions: Effects of
repeated ethanol deprivations. Alcoholism: Clinical and Experimental Research 31: 74A. Presented
at the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007
280. Pommer T J, Oster S M, Toalston JE, Murphy JM, Bell RL, McBride WJ, Rodd ZA. Introduction of a
‘lock-out’ during concurrent access to multiple ethanol concentrations: Effects of repeated
deprivations Alcoholism: Clinical and Experimental Research 31: 74A. Presented at the 30th annual
meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007
James M. Murphy
38
281. Franklin KM, Engleman EA, Ingraham CM, Sentir AM, McBride WJ, Murphy JM. Effects of single
and repeated systemic ethanol administration on dopamine D2 autoreceptor function in the nucleus
accumbens of Wistar rats. Alcoholism: Clinical and Experimental Research 31: 84A. Presented at
the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007
282. Engleman EA, Ingraham CM, Franklin KM, Keith CM, McClaren JA, Morzorati SL, O’Connor S,
Thielen RJ, Murphy JM, McBride WJ. Measuring ethanol levels using subcutaneous microdialysis.
Alcoholism: Clinical and Experimental Research 31: 177A. Presented at the 30th annual meeting of
the Research Society on Alcoholism, Chicago, IL July 7-11, 2007
283. Toalston JE, Murphy JM, Bell RL, McBride WJ. ADOLESCENT CONSUMPTION OF Ethanol, but
not saccharin, increases the reinforcing properties of ethanol in adulthood. Alcoholism: Clinical and
Experimental Research 31: 307A. Presented at the 30th annual meeting of the Research Society on
Alcoholism, Chicago, IL July 7-11, 2007
284. Engleman EA, Ingraham CM, Sentir AM, Franklin KM, McBride WJ, Murphy JM. Heterogenity of 5HT3 effects in the shell and core subregions of the nucleus accumbens. Society for Neuroscience
Abstracts 780.19/E40. Presented at the 37th annual meeting of the Society for Neuroscience, San
Diego, CA, November 3-7, 2007
285. Franklin KM, Engleman EA, Ingraham CM, W. J. McBride WJ, Murphy JM. A single, moderate
ethanol exposure increases extracellular dopamine levels and reduces extraction fractions in the
nucleus accumbens of Wistar rats. Society for Neuroscience Abstracts 909.18/FF2. Presented at
the 37th annual meeting of the Society for Neuroscience, San Diego, CA, November 3-7, 2007
286. Cook JB, Bracken AL, Rodd ZA, Toalston, JE, Lumeng L, Murphy JM, McBride WJ, Bell RL. The
effects of ethanol consumption during peri-adolescence or adulthood on subsequent ethanolinduced motor impairment in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental
Research 32: 91A. Presented at the Joint Scientific Meeting of the Research Society on Alcoholism
and the International Society for Biomedical Research on Alcoholism, June 27-July 2, 2008,
Washington, D.C
287. Oster SM, Ding Z-M, Hauser SR, Pommer TJ, Bell RL, Murphy JM, McBride WJ, Rodd ZA.
Microinjection of atrial naturietic peptide into the nucleus accumbens shell reduces ethanol selfadministration in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 32:
166A. Presented at the Joint Scientific Meeting of the Research Society on Alcoholism and the
International Society for Biomedical Research on Alcoholism, June 27-July 2, 2008, Washington,
D.C
288. Oster SM, Z.M. Ding, Toalston, JE, Bell RL, Pommer TJ, Lumeng L, Murphy JM, Rodd ZA, WJ
McBride. Alcohol drinking increases the sensitivity of the nucleus accumbens shell to the reinforcing
effects of cocaine in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 32:
166A. Presented at the Joint Scientific Meeting of the Research Society on Alcoholism and the
International Society for Biomedical Research on Alcoholism, June 27-July 2, 2008, Washington,
D.C
289. Dhaher R, Rodd ZA, Whalen CP, Getachew B, Hauser S, McBride WJ, Murphy JM, Bell RL.
Lesions of the amygdala, but not the nucleus accumbens, decrease the maintenance of ethanol
self- administration in alcohol-prefering (P) rats. Alcoholism: Clinical and Experimental Research
32: 167A. Presented at the Joint Scientific Meeting of the Research Society on Alcoholism and the
International Society for Biomedical Research on Alcoholism, June 27-July 2, 2008, Washington,
D.C.
290. Franklin KM, Engleman EA, Blankenship RL, Ingraham CM, Murphy JM. Caffeine increases ethanol
self-administration in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research
33: 223A. Presented at the Annual Meeting of the Research Society on Alcoholism, June 20-24,
2009, San Diego, CA
291. Engleman EA, Ingraham CM, Franklin KM, Blankenship RL, McBride WJ, Murphy JM. Chronic
ethanol (EtOH) drinking increased dopamine (DA) transmission in the ventral pallidum (VP) and the
prefrontal cortex (PFC). Alcoholism: Clinical and Experimental Research 33: 80A. Presented at the
Annual Meeting of the Research Society on Alcoholism, June 20-24, 2009, San Diego, CA
292. Toalston JE, Rodd ZA, Oster SM, Bell RL, Murphy JM, McBride WJ. Peri-adolescent ethanol
drinking increases the sensitivity of the ventral tegmental area to the reinforcing effects of ethanol in
adulthood. Alcoholism: Clinical and Experimental Research 33: 96A. Presented at the Annual
Meeting of the Research Society on Alcoholism, June 20-24, 2009, San Diego, CA
James M. Murphy
39