Zhigang Tian, M.D., Ph.D
.
Professor & Director, Institute of Immunology
University of Science & Technology of China
443 Huangshan Street, Hefei City, Anhui 230027, P.R.China
Tel:(551) 360-0845 ; 360-7379 (Sectarian); 3607377(Lab)
Fax: (551) 360-6783; E.mail: tzg@ustc.edu.cn;
Education and Appointment
05/2001–present: Professor, Univ Sci Tech China, China
04/1989-05/2001: Assist/Asso/Full Professor, Shandong Acad Med Sci, China
03/1986-03/1989: Ph.D., Immunology, Normal Bethune Med Univ, China.
03/1983-08/1985: M.S.,Immunol,Shandong Acad Med Sci, China
03/1978-12/1982: M.D., Shanxi Medical University, China
05/2002–04/2003: Visiting Professor, Kanazawa Univ Cancer Inst, Japan
1/2002–4/2002, Visiting Scientist, NIAAA, NIH, USA
2/1999–8/1999: Visiting Professor, Med College Virginia, Richmond, USA
8/1994-6/1996: Visiting Scientist, NCI, NIH, USA
Speciality & Research Field of Interest
NK cells, liver immunology and major diseases (cancer, infection and autoimmunity)
Resent Selective Publications
1. Han QJ, Zhang C, Zhang J, Tian ZG. Reverse of HBV-induced immune tolerance by an immunostimulatory 3p-HBx-siRNA in a retinoic acid inducible gene I (RIG-I) -dependent manner. Hepatology 2011 , in press.
2.
Jin Z, Sun R, Wei H, Gao X, Chen Y, Tian Z. Accelerated liver fibrosis in hepatitis B virus transgenic mice: Involvement of natural killer T cells. Hepatology. 2010 ; 53:219-29
3.
Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis. Hepatology 2009 , 49:940-9
4.
Gao B, Jeong WI, Tian Z. Liver: An organ with predominant innate immunity.
Hepatology. 2008 ; 47:729-36.
5.
Chen QF, Wei HM, Sun R, Zhang J, Tian Z. Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury.
Hepatology 2008 , 47:648-58
6.
Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology. 2007 ; 46(3):706-15.
7.
Zhou R, Wei H, Sun R, Tian ZG. NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice
Proc Natl Acad Sci U S A. 2007 ; 104(18):7512-5.
8.
Dong Z, Zhang J, Sun S, Wei H, Tian ZG. Impairment of liver regeneration correlates with over-activated hepatic NKT cells in HBV transgenic mice. Hepatology 2007;
45(6):1400-12.
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9.
Li B, Sun R, Wei H, Gao B, Tian ZG. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. Hepatology. 2006 ;
43(6):1211-9.
10.
Jiang W, Sun R, Wei HM, Tian ZG. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Proc
Natl Acad Sci USA 2005 ; 102 (47): 17077-17082.
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