noninvasive
revolutionary
Blood Cell Storage Inc.
North Canal Office Park
146 North Canal Street
Suite No. 330
Seattle, WA 98103, USA
Tel.: 206-632-7314
Fax: 206-632-7349
info@bloodcellstorage.com
www.bloodcellstorage.com
noninvasive
“...it’s in the bag”
“...it’s in the bag”™
revolutionary
Publications and Presentations
Platelet Concentrates in pH Reading Containers
M. Dijkstra-Tiekstra, J. de Wildt-Eggen, L. Scholten-Pijper, A. Setroikromo, C. van Delden
Time Course of pH in Platelet Concentrates after Bacterial Contamination
T. Montag, S.-B. Nicol, U. Schurig, J Brachert, A. Sauer, T, Müller, C.K. Schneider Paul-Ehrlich Institut,
Mikrobielle Sicherheit, D Langen, German Red Cross-Blood Transfusion Service NSTOP, D Institute Springe
Non-Invasive Measurement of Platelet Concentrate pH with Fiber Optic Fluorescence Detector: D. de Korte,
R. Vlaar, Eric C.W.N Gouwerok, I. De Cuyper, E. Jan Klip, A. Verhoeven, Sanquin Research at CLB, Amsterdam,
Netherlands; M. Reed, S. Geelhood, BCSI Seattle, WA USA
Daily Non-Invasive Fluorescence Ratio Measurement of Platelet Concentrate pH Can Detect the Presence
of Bacteria: L. Barker, O. Nanassy, M. Reed, S. Geelhood, R. Pfalzgraf, BCSI Seattle, WA; G. Cangelosi,
Seattle Biomedical Research Institute, Seattle, WA. (AABB 2006 SP49)
Non-Invasive Measurement of Platelet Concentrate pH with a Fiber Optic Fluorescence Detector: M.W. Reed, S.J.
Geelhood, BCSI, Seattle, WA USA; A.J. Verhoeven, D. de Korte, Sanquin Research at CLB, Amsterdam, Netherlands
Effect of Extracellular pH on Platelet Concentrate: D. de Korte, D.W.C. Dekkers, I.M. De Cuyper, R. Verhaar,
P. van der Meer, and A.J. Verhoeven; Sanquin Research at CLB, Amsterdam, Netherlands
The Efficacy and Platelet Biocompatibility of a Non-invasive Fluorescent pH Detector, S.J. Geelhood1, M.W. Reed1,
T.A. Horbett2, 1 Blood Cell Storage, Inc. Seattle, WA, 2University of Washington, Seattle, WA
BCSI pH1000 Specifications
Dimensions
LxWxH
36 cm x 39.7 cm x 11.4 cm
(14.2 in x 15.6 in x 4.5 in)
Weight
2.35 kg (5.2 lbs)
External Connections
• PS2 for Barcode Reader
• RS-232 DB-9 (male), for serial communication
• Ethernet
Power Requirements
(AC Power Adapter)
Input power to power adapter:
• 100 - 240 VAC, 50 to 60 Hz, 0.6 A max, 15 W max
• Main supply voltage fluctuations must not exceed ± 10% of nominal value.
• Transient over voltages typically present on the main supply is expected to be impulse
withstand (over voltage) category II of IEC 60364-4-43.
Adapter output power: 9VDC, 1.7A max.
(Note: Input connectors are available for; Continental Europe, the United Kingdom,
North America and Australia.)
Operating Temperature Range
5 - 40°C (41 - 104°F)
Operating Humidity Range
5 - 80% relative humidity, non-condensing
Operating Altitude
Maximum altitude 2000 m (6562 ft.)
Pollution Degree Classification
Pollution Degree 2
Operating Environment
The instrument is intended for indoor use only.
Transport and Storage
Conditions
Temperature: -10 - 50°C (14 - 122°F)
Humidity: 5 - 98% relative humidity, non-condensing
Atmospheric pressure: 50 kPa - 106 kPa (0.5 atm - 1 atm)
Keypad
10 character alphanumeric keys
2 special function keys
Display
2 line by 20 character Liquid Crystal Display (LCD)
BCSI pH1000
™
World’s first noninvasive
Platelet Concentrate pH Detector.
BCSI pH1000 Platelet Storage Bag Specifications
NOT FOR SALE IN THE U.S.
Volume:
1300 ml total for a nominal 300 ml of platelet concentrate
Sample Ports:
2 twist off sample ports
Fluid Path:
Sealed, sterile, pyrogen free & excellent biocompatibility
Material:
PVC/citrate — Soft flexible film with high transparency
pH Reading:
Fast and accurate reading from pH 6.2 to 7.8 (reported at 22°C)
Blood Cell Storage Inc.
© BCSI 2007
10/07
CE MARK 0344
NOT FOR SALE IN THE U.S.
CE MARK 0344
• pH is an indicator of platelet quality
The BCSI pH1000: Platelet Concentrate
pH Detector System
• Low or rapidly declining pH may identify units with:
BCSI developed a novel and proprietary system that provides a method for
– Transportation damage
noninvasively monitoring the health of platelets inside the bag. BCSI’s optical
– Poor storage characteristics
sensing technology is incorporated directly into a platelet storage bag, allowing
– Bacterial contamination
multiple measurements with no sampling. The BCSI pH1000 detection system
• Most countries require pH measurement
consists of a fluorometer that measures light emissions and a biochemical sensor
Why Use a Non-Invasive System?
located in an insert incorporated into one of the platelet bag’s ports (“...it’s in the
• Eliminates the risk of contaminating platelet units during pH testing
and intensity as proprietary biochemicals in the insert sense pH changes inside the
• Eliminates loss of platelets due to quality control
bag. The fluorometer measures the fluorescent light intensity of the biochemical
• Rapid, easy-to-use, non-invasive system allows every bag to be measured
sensor. The reading is not affected by different colors of plasma, including those
• pH1000™ reduces the likelihood of user error
from women on contraceptives, those containing excessive fat, and those with high
Why Measure pH of Stored Platelets?
bag”). When the sensor is illuminated, it emits a glow. This glow changes color
red blood cell counts. The optical sensing technology allows noninvasive pH
monitoring of the health of platelets, it allows for multiple readings over days of
storage while maintaining the sterility within the bag.
BCSI pH1000: pH Measured Over Time
BCSI pH1000 tracks pH
accurately over days
7 .5
BCSI pH
7 .4
Four sterile BCSI platelet
storage bags with pH reading
inserts were equipped with
septum adaptors to allow
daily (invasive) reading with
a Bayer Rapidlab blood gas
analyzer. Noninvasive BCSI pH
readings were consistent
with the blood gas readings.
The mean difference from
average pH determined
by both methods was 0.045
(n=32, SD 0.058).
Blood Gas pH
7 .3
BCSI pH Detector “...it’s in the bag”
Fast – takes only seconds per measurement, including self-calibration
User Friendly – easy to use
NonInvasive – eliminates risk of contamination
REVOLUTIONARY – take multiple readings up to time of transfusion
ECONOMICAL – allows optimal use of scarce resources
Space Efficient – only 36 cm x 39.7 cm (14.2 in x 15.6 in)
pH AT 37°C
7 .2
7 .1
7
6 .9
6 .8
6 .7
6 .6
6 .5
0
1
2
3
4
5
6
7
STORAGE TIME, DAYS
8
9
10
11