Berocca® is suitable for regular consumption The tailored multi-vitamin supplement by Bayer contains all essential nutrients to optimize mental and physical performance Maintaining a healthy and active lifestyle is key to perform above average, both mentally and physically. However, since the modern world moves at a fast pace, many achievement-driven individuals face a lot of challenges and stressful situations, which in turn leads to a quicker depletion of essential nutrients. Supplementation with multi-vitamin and mineral combinations, such as Berocca®, helps promote good health. Berocca® can easily be added to the daily diet and fill most nutrient gaps to provide the energy that is needed for sustained performance. Vitamins and minerals are necessary to improve growth and development of living cells and are important components in cell metabolism. Humans are not able to synthesize all vitamins necessary for the body. Instead, these compounds need to be regularly taken in through food. Studies show that the body does not distinguish between synthetic and natural vitamins1 as many synthetic versions of vitamins are chemically identical to their natural counterparts. There is, however, a difference between fat-soluble and watersoluble vitamins. Fat-soluble vitamins, such as vitamin A, can easily accumulate in the body and therefore cause adverse effects at high concentrations. Because water-soluble vitamins are generally not stored in the body and display a favorable safety profile, an upper intake level for this group often does not exist. 1 Mangels AR, Block G, Frey CM et al. The bioavailability to humans of ascorbic acid from oranges, orange juice, and cooked broccoli is similar to that of synthetic ascorbic acid. J Nutr 1993;123:1054-1061. - 1/3 - As a neurotropic vitamin combination, Berocca® Performance only contains the watersoluble vitamins B1 (thiamine), B2 (riboflavin), B3 (niacin/nicotinamide), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folic acid), B12 (cobalamine) and vitamin C. In addition, Berroca® Performance contains calcium, magnesium, and zinc. All these vitamins and minerals are essential for both body and mind. During stressful periods, mild deficiencies in these vitamins and minerals are enough to cause exacerbation of deficiency symptoms such as irritability, fatigue, and diminished concentration. In Berocca® Performance, all micronutrients are high-dosed to counteract subclinical deficiencies. Nevertheless, the dosages conform to European food standards and are well in line with Tolerable Upper Intake Levels (UL), as established by the European Food Safety Authority. ULs describe how much micronutrient an individual can take long-term without suffering any adverse health effects. For water-soluble vitamins, often there is no UL defined and therefore marked as “not determinable” (ND) due to lack of data of adverse effects. This is because vitamins from this group are readily excreted via urine and thus rarely accumulate within the body to cause any such adverse effects. Table 1: Current formula of Berocca® Performance 2 Ingredient Dosage UL (EU)2 Vitamin B1 15 mg ND Vitamin B2 15 mg ND Nicotinamide 50 mg 900 mg Pantothenic acid 23 mg ND Vitamin B6 10 mg 25 mg Biotin 150 µg ND Folic acid 400 µg 1,000 µg Vitamin B12 1 µg ND Vitamin C 500 mg ND Calcium 100 mg 2,500 mg Magnesium 100 mg 250 mg (only supplements or additives) Zinc 10 mg 25 mg Italy. Scientific Committee on Food and Scientific Panel on Dietetic products, Nutrition and Allergies. Tolerable Upper Intake Levels for Vitamins and Minerals Tolerable Upper Intake Levels for Vitamins and Minerals. Parma: European Food Safety Authority (EFSA); 2006. - 2/3 - Berocca® Performance is one of the most well-studied multi-vitamin supplementations, therefore its efficacy and safety are backed by many randomized controlled clinical trials.3 They underline Berocca® Performance’s high safety profile, even with regard to a regular daily consumption over long periods. Even though Berocca ® Performance contains high doses of multi-vitamins, it is not recommended as a substitute for proper sleep habits, diet or nutrition. About Bayer HealthCare The Bayer Group is a global enterprise with core competencies in the fields of health care, agriculture and high-tech materials. Bayer HealthCare, a subgroup of Bayer AG with annual sales of EUR 18.9 billion (2013), is one of the world’s leading, innovative companies in the healthcare and medical products industry and is based in Leverkusen, Germany. The company combines the global activities of the Animal Health, Consumer Care, Medical Care and Pharmaceuticals divisions. Bayer HealthCare’s aim is to discover, develop, manufacture and market products that will improve human and animal health worldwide. Bayer HealthCare has a global workforce of 56,000 employees (Dec 31, 2013) and is represented in more than 100 countries. More information is available at www.healthcare.bayer.com. Our online press service is just a click away: press.healthcare.bayer.com Follow us on Facebook: http://www.facebook.com/healthcare.bayer Follow us on Twitter: https://twitter.com/BayerHealthCare Contact: Patrick Kaiser, Phone +41 58 272-7616 E-mail: patrick.kaiser@bayer.com September 2014 Forward-Looking Statements This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer’s public reports which are available on the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments. 3 Kennedy DO, Haskell CF. Vitamins and cognition: what is the evidence? Drugs 2011;71(15):1957-1971. - 3/3 -