blood
JOURNAL OF
THE AMERICAN
SOCIETY OF
HEMATOLOGY
Blood, Journal of The American Society of Hematology
(print ISSN 0006-4971, online ISSN 1528-0020), is published semimonthly, except 3 times in November, by The
American Society of Hematology (ASH), 1900 M Street,
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futurearticles
15 JULY 2008
ASH 50TH ANNIVERSARY REVIEW
Forging a field: the golden age of iron biology
N. C. Andrews
PERSPECTIVE
The revised World Health Organization diagnostic criteria for polycythemia vera,
essential thrombocytosis, and primary myelofibrosis: an alternative proposal
J. L. Spivak and R. T. Silver
REVIEW ARTICLE
Dynamics of factor VIII interactions determine its immunologic fate in hemophilia A
S. Lacroix-Desmazes, A.-M. Navarrete, S. André, J. Bayry, S. V. Kaveri, and S. Dasgupta
HOW I TREAT
Acquired factor VIII inhibitors
M. Franchini and G. Lippi
CHEMOKINES,
CYTOKINES, AND
INTERLEUKINS
Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with
increased levels of ligand in circulation and tissues
A. E. Cardona, M. E. Sasse, L. Liu, M. Mizutani, S. M. Cardona, C. Savarin, T. Hu, and
R. M. Ransohoff
Coactivator function of RIP140 for NF␬B/RelA-dependent cytokine gene expression
I. Zschiedrich, U. Hardeland, A. Krones-Herzig, M. Berriel Diaz, A. Vegiopoulos, J. Müggenburg,
D. Sombroek, T. G. Hofmann, R. Zawatzky, X. Yu, N. Gretz, M. Christian, R. White, M. G. Parker, and
S. Herzig
CLINICAL TRIALS AND
OBSERVATIONS
Common variable immunodeficiency disorders: division into distinct clinical phenotypes
H. Chapel, M. Lucas, M. Lee, J. Bjorkander, D. Webster, B. Grimbacher, C. Fieschi, V. Thon,
M. R. Abedi, and L. Hammarstrom
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15 JULY 2008
Idiopathic CD4ⴙ lymphocytopenia: natural history and prognostic factors
D. I. Zonios, J. Falloon, J. E. Bennett, P. A. Shaw, D. Chaitt, M. W. Baseler, J. W. Adelsberger,
J. A. Metcalf, M. A. Polis, S. J. Kovacs, J. A. Kovacs, R. T. Davey, H. C. Lane, H. Masur, and I. Sereti
HEMATOPOIESIS AND
STEM CELLS
PDGF, TGF-b, and FGF signaling is important for differentiation and growth of
mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and
signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic,
and ostoegenic lineages
F. Ng, S. Boucher, S. Koh, K. S. R. Sastry, L. Chase, U. Lakshmipathy, C. Choong, Z. Yang,
M. C. Vemuri, M. S. Rao, and V. Tanavde
Notch-dependent control of myelopoiesis is regulated by fucosylation
L. Zhou, L. W. Li, Q. Yan, B. Petryniak, Y. Man, C. Su, J. Shim, S. Chervin, and J. B. Lowe
Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis
D. L. Waning, B. Li, N. Jia, Y. Naaldijk, W. S. Goebel, H. HogenEsch, and K. T. Chun
HEMOSTASIS,
THROMBOSIS, AND
VASCULAR BIOLOGY
ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized
phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein
response
O. V. Oskolkova, T. Afonyushkin, A. Leitner, E. von Schlieffen, P. S. Gargalovic, A. J. Lusis,
B. R. Binder, and V. N. Bochkov
Synergistic interactions between interferon-␥ and TRAIL modulate c-FLIP in endothelial
cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura
plasma–associated apoptosis
R. Stefanescu, D. Bassett, R. Modarresi, F. Santiago, M. Fakruddin, and J. Laurence
Interleukin-3 promotes expansion of hemopoietic-derived CD45ⴙ angiogenic cells and
their arterial commitment via STAT5 activation
A. Zeoli, P. Dentelli, A. Rosso, G. Togliatto, A. Trombetta, L. Damiano, P. F. di Celle, L. Pegoraro,
F. Altruda, and M. F. Brizzi
IMMUNOBIOLOGY
Tumor-specific Th17-polarized cells eradicate large established melanoma
P. Muranski, A. Boni, P. A. Antony, L. Cassard, K. R. Irvine, A. Kaiser, C. M. Paulos, D. C. Palmer,
C. E. Touloukian, K. Ptak, L. Gattinoni, C. Wrzesinski, C. S. Hinrichs, K. W. Kerstann, L. Feigenbaum,
C.-C. Chan, and N. P. Restifo
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NEOPLASIA
Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
Y.-W. Qiang, J. D. Shaughnessy Jr, and S. Yaccoby
Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell
leukemia/lymphoma
T. Hidaka, S. Nakahata, K, Hatakeyama, M. Hamasaki, K. Yamashita, T. Kohno, Y. Arai, T. Taki,
K. Nishida, A. Okayama, Y. Asada, R. Yamaguchi, H. Tsubouchi, J. Yokota, M. Taniwaki, Y. Higashi,
and K. Morishita
Brief report SAGE analysis demonstrates increased expression of TOSO contributing to
Fas-mediated resistance in CLL
R. Proto-Siqueira, R. A. Panepucci, F. P. Careta, A. Lee, A. Clear, K. Morris, C. Owen, E. G. Rizzatti,
W. A. Silva Jr, R. P. Falcão, M. A. Zago, and J. G. Gribben
RED CELLS
Vascular dysfunction in a murine model of severe hemolysis
A. C. Frei, Y. Guo, D. W. Jones, K. A. Pritchard Jr, K. A. Fagan, N. Hogg, and N. J. Wandersee
H3 K79 dimethylation marks developmental activation of the ␤-globin gene but is reduced
upon LCR-mediated high-level transcription
T. Sawado, J. Halow, H. Im, T. Ragoczy, E. H. Bresnick, M. A. Bender, and M. Groudine
TRANSPLANTATION
Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic
hematopoietic cell transplantation: particular activity against advanced hematologic
malignancies
R. Marks, K. Potthoff, J. Hahn, G. Ihorst, H. Bertz, A. Spyridonidis, E. Holler, and J. Finke
Unrelated donor transplants in adults with Philadelphia-negative acute lymphoblastic
leukemia in first complete remission
D. I. Marks, W. S. Pérez, W. He, M.-J. Zhang, M. R. Bishop, B. J. Bolwell, C. N. Bredeson,
E. A. Copelan, R. P. Gale, V. Gupta, G. A. Hale, L. M. Isola, A. A. Jakubowski, A. Keating,
T. R. Klumpp, H. M. Lazarus, J. L. Liesveld, R. T. Maziarz, P. L. McCarthy, M. Sabloff, G. Schiller,
J. Sierra, M. S. Tallman, E. K. Waller, P. H. Wiernik, and D. J. Weisdorf
The reactivity of Bw4ⴙ HLA-B and HLA-A alleles with KIR3DL1: implications for patient
and donor suitability for haploidentical stem cell transplantations
B. A. Foley, D. De Santis, E. Van Beelen, L. J. Lathbury, F. T. Christiansen, and C. S. Witt
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