RESEARCH PAPERS, BOOK CHAPTERS, BOOKS, GUEST EDITOR OF JOURNALS , COMMENTARIES FOR FACULTY OF 1000 RESEARCH PAPERS 1. Mahesh, V.B., Narasimhachari, N. and Seshadri, T.R. Synthetic Experiments in the Benzopyrone Series, Part XLII. A New Synthesis of 5:6:7-Trihydroxy Isoflavone Derivatives. Proc. Indian Acad.Sci. 39A:165-175, 1954. 2. Mahesh, V.B. and Seshadri, T.R. Chemical Components of Commerical Woods and Related Plant Materials. II. The Heartwood of Pinus encelsa Wall. J. Industr. Res. (India) 13B:835-841, 1954. 3. Mahesh, V.B. and Seshadri, T.R. Hydroxylation of Flavanones in the 3-Position. J. Chem. Soc. 2503-2505, 1955. 4. Mahesh, V.B. and Seshadri, T.R. Stereochemistry of 3-Hydroxy Flavanones. Proc. Indian Acad. Sci. 41A:210-223, 1955. 5. Mahesh, V.B. and Seshadri, T.R. Iodine Oxidation (Dehydrogenation) of Hydroxy-Flavanones to Hydroxy-Flavones. J. Sci. Industr. Res. (India) 14B:608-609, 1955. 6. Mahesh, V.B. and Seshadri, T.R. Isomerization of Isoflavones in Alkaline Medium. J. Sci. Industr. Res. (India) 14B: 671-672, 1955. 7. Mahesh, V.B., Neelakantan, S. and Seshadri, T.R. Selective Methylation of Chelated Hydroxyl Groups. J. Sci. Industri. Res. (India) 15B: 287-292, 1956. 8. Goel, R.N., Mahesh, V.B. and Seshadri, T.R. Modifications in the Iodine Oxidation of Hydroxy Flavanones and Their Methyl Ethers. Proc. Indian Acad. Sci. 47A:184-190, 1958. 9. Bush, I.E. and Mahesh, V.B. Adrenocortical Hyperfunction with Sudden Onset of Hirsutism J.Endocrinol. 18:1-25, 1959. 10. Bush, I.E. and Mahesh, V.B. Metabolism of 11-Oxygenated Steroids: Influence of theA/B Ring Junction on the Reduction of 11-Oxo Groups. Biochem. J. 71:705-717, 1959. 11. Bush, I.E. and Mahesh, V.B. Metabolism of 11-Oxygenated Steroids. Biochem. J. 71:718-742, 1959. 12. Mahesh, V.B. and Ulrich, F. Distribution of Enzyme Systems Responsible for Steroid Metabolism in Different Tissues and Subcellular Fractions. Nature 184:1147-1148, 1959. 13. Mahesh, V.B. and Ulrich, F. Metabolism of Cortisol in Various Tissues and Subcellular Particles. J. Biol. Chem. 235:356-360, 1960. 14. Conrad, S., Mahesh, V.B. and Herrmann, W. Quantitative Paper Chromatography of Conjugated 17-Ketosteroids in Plasma. J. Clin. Invest. 40:947-953, 1961. 15. Mahesh, V.B. and Greenblatt, R.B. Physiology and Pathogenesis of the Stein-Leventhal Syndrome. Nature 191:888-890, 1961. 16. Mahesh, V.B. and Greenblatt, R.B. Isolation of Dehydroepiandrosterone and 17alpha-Hydroxy-delta-5-Pregnenolone From the Polycystic Ovaries of the Stein-Leventhal Syndrome. J. Clinical Endocrinol Metab. 22:441-448, 1962. 17. Greenblatt, R.B., Roy, S., Mahesh, V.B., Barfield, W.E. and Jungck, E.C. Induction of Ovulation. Am. J. Obstet.Gynecol. 84:900-912, 1962. 18. Mahesh, V.B., Greenblatt, R.B., Aydar, C.K. and Roy, S. Secretion of Androgens by the Polycystic Ovary and Its Significance. Fertil. Steril. 13:513-530, 1962 19. Roy, S., Mahesh, V.B. and Greenblatt, R.B. Effect of Dehydroepiandrosterone and delta-4-Androstenedione on the Reproductive Organs of Female Rats: Production of Cystic Change in the Ovary. Nature 196:42-43, 1962. 20. Mahesh, V.B. and Herrmann, W. Isolation of Estrone and 11-Hydroxy Estrone from a Feminizing Adrenal Carcinoma. Steroids 1:51-61, 1962. 21 Mahesh,V.B .and Greenblatt, R.B. The In Vivo Conversion of Dehydroepiandrosterone and Androstenedione to Testosterone in the Human. Acta. Endocrinol. 41:400-406, 1962. 22. Roy, S., Greenblatt, R.B., Mahesh, V.B. and Jungck, E.C. Clomiphene Citrate: Further Observations on its Use in Induction of Ovulation in the Human and On Its Mode of Action. Fertil. Steril. 14:575-595, 1963. 23. Morris, J.M. and Mahesh, V.B. Further Observations on the Syndrome, "Testicular Feminization." Am. J. Obstet. Gynecol. 87:731-745, 1963. 24. Jungck, E.C., Roy, S., Greenblatt, R.B. and Mahesh, V.B. Effect of Clomiphene Citrate on Spermatogenesis in the Human. Fertil. Steril. 15:40-43, 1964. 25. Greenblatt, R.B., Mahesh, V.B., Rigas, L.C. and Shapiro, S.T. Physiologic and Clinical Aspects of Ovarian Hormones. Arch. Dermatol. 69:846-857, 1964. 26. Greenblatt, R.B., Dominquez, H., Mahesh, V.B. and Demos, R.J. Gondal Dysgenesis Intersex with X0/XY Mosaicism. J. Am. Med. Assoc. 188:221-224, 1964. 27. Roy, S. and Mahesh, V.B. Changes in Steroid Content of the Adrenal of Rats Following Prolonged Administration of Testosterone Propionate with or without ACTH. Endocrinology, 74:187-192, 1964. 28. Roy, S., Greenblatt, R.B. and Mahesh, V.B. Effects of Clomiphene and Intrasplenic Ovarian Autotransplantation on the Anovulatory Cystic Ovaries of Rats Having Androgen-Induced Persistent Estrus. Fertil. Steril. 15:310-316, 1964. 29. Mahesh, V.B. and Greenblatt, R.B. Steroid Secretions of the Normal and Polycystic Ovary. Recent Prog. Horm. Res. 20:341-394, 1964. 30. Mahesh, V.B. A Paper Chromatographic Method for Estrogen Determination. Steroids 3: 647-661, 1964. 31. Roy, S., Mahesh, V.B. and Greenblatt, R.B. Effects of Clomiphene on the Physiology of Reproduction in the Rat.Changes in the Hypophyseal-Gonadal Axis. Acta. Endocrinol. 47: 645-656, 1964. 32. Roy, S., Greenblatt, R.B. and Mahesh, V.B. Effects of Clomiphene on the Physiology of Reproduction in the Rat. II. Its Oestrogenic and Antioestrogenic Actions. Acta. Endocrinol. 47:657-668, 1964. 33. Roy, S., Mahesh, V.B. and Greenblatt, R.B. Effects of Clomiphene on the Physiology of Reproduction in the Rat. III. Inhibition of Uptake of Radioactive Oestradiol by the Uterus and the Pituitary Gland of Immature Rat. Acta. Endocrinol. 47:669-675, 1964. 34. Greenblatt, R.B. and Mahesh, V.B. Clinical Evaluation and Treatment of the Hirsute Female. Clin. Obstet. Gynecol. 7:1109-1119, 1964. 35. Greenblatt, R.B. and Mahesh, V.B. The Hirsute Female. North Carolina Medical Journal 25:190-194, 1964. 36. Byrd, J.R., Mahesh, V.B. and Greenblatt, R.B. Chromosomal Studies in the Stein-Leventhal Syndrome. J. Clin. Endocrinol. Metab. 24:939-940, 1964. 37. Mahesh, V.B., Greenblatt, R.B., Aydar, C.K., Roy, S., Puebla, R.A. and Ellegood, J.O. Urinary Steroid Excretion Patterns in Hirsutism. I. Use of Adrenal and Ovarian Suppression Tests in the Study of Hirsutism. J. Clin. Endocrinol. Metab. 24:1283-1292, 1964. 38. Mahesh, V.B. and Greenblatt, R.B. Urinary Steroid Excretion Patterns in Hirsutism. II:. Effect of Ovarian Stimulation with Human Pituitary FSH on Urinary 17-Ketosteroids. J. Clin. Endocrinol. Metab. 24:1293-1302, 1964. 39. Bush, I.E. and Mahesh, V.B. Metabolism of 11-Oxygenated Steroids. 1-Dehydro and 9-Fluoro Steroids. Biochem. J. 93:236-255, 1964. Some 40. Mahesh, V.B. Steroid Secretions Polycystic (Stein-Leventhal) Ovaries. Proceedings of the II International Congress of Endocrinology, Excerpta Med. Int. Congr. Ser. No. 83:944-949, 1964. 41. Greenblatt, R.B. and Mahesh, V.B. Pituitary-Ovarian Relationships. Metabolism 14:320-326, 1965. 42. Sato, T., Mahesh, V.B. and Greenblatt, R.B. Effect of Clomiphene Citrate (MRL 41) on Thyroid Function of Female Rats. Endocrinology 77:491-495, 1965. 43. Greenblatt, R.B., Zarate, A. and Mahesh, V.B. Methods Available for the Induction of Ovulation. Proceedings of the VI Pan American Congress of Endocrinology, Excerpta Med. Int. Congr. Ser. 112:129-133, 1965. 44. Mahesh, V.B. Androgen Secretion and Virilization. Proceedings of the VI Pan American Congress of Endocrinology, Excerpta Medica International Congress Series 112:213-217, 1965. 45. Haznam, M.W., Mahesh, V.B. and Greenblatt, R.B. Absorption of Topically Applied Estrogen Preparations. Dermatol. Int. 4: 86-91, 1965. 46. Sato, T., Greenblatt, R.B. and Mahesh, V.B. Levels of Luteinizing Hormone During the Menstrual Cycle Determined by Immunologic Techniques. Fertil. Steril. 16:223-228, 1965. 47. Greenblatt, R.B., McDonough, P.G. and Mahesh, V.B. Estrogen Therapy in Inhibition of Growth. J. Clin. Endocrinol. Metab. 26:1185-1191, 1966. 48. Mahesh, V.B., Zarate, A., Roper, B.K. and Greenblatt, R.B. Studies on the Action of 17-alpha Methyl-B-Nortestosterone as an Antiandrogen. Steroids 8:297-308, 1966. 49. Mahesh, V.B. Androgen Secretion in the Stein-Leventhal Syndrome. Proceedings of the Royal Society of Medicine 59:51-53, 1966. 50. Greenblatt, R.B., Faucher, G., Mahesh, V.B., Lunenfeld, B., Rabau, E., David, A. and Insler, V. Ovulation and Pregnancy in the Chiari-Frommel Syndrome, Report of 10 Cases. Fertil. Steril. 17:742-756, 1966. 51. Zarate, A., Mahesh, V.B. and Greenblatt, R.B. Effect of an Antiandrogen, 17alpha-Methyl-B- Nortestosterone, on Acne and Hirsutism. J. Clin. Endocrinol. Metab. 26:1394-1398, 1966. 52. Greenblatt, R.B., Mahesh, V.B. and Zarate, A. La Ovulation en el Humano. Sobretiro de la Revista de Investigacion Clinica Mexico, D.F. Vol. 28:477-483, 1966. 53. Uberoi, N.K., Mahesh, V.B., Black, J.B. and Meyer, R.K. Effect of 17alpha-Methyl-B- Nortestosterone on Ovulation and Ovarian Weight in Female Rats. Steroids 9:245-255, 1967. 54. Greenblatt, R.B., McDonough, P.G. and Mahesh, V.B. Le Syndrome de L'Exces Statural Chez La Jeune Fille. Gazaette Medicale de France 2:759-768, 1967. 55. Mahesh, V.B., McDonough, P.G. and Greenblatt, R.B. Endocrine Studies in a Patient with Virilism, Ovarian Stromal Hyperplasia, and Endometrial Carcinoma. Obstet. Gynecol. 30: 584-590, 1967. 56. Greenblatt, R.B., Byrd, J.R., McDonough, P.G. and Mahesh, V.B. The Spectrum of Gonadal Dysgenesis: A Clinical, Cytogenetic and Pathologic Study. Am. J. of Obstet. Gynecol. 98:151-172, 1967. 57. Greenblatt, R.B., McDonough, P.G. and Mahesh, V.B. Projection of Growth. J. of Clin. Endocrinol. 27:1761, 1967. 58. Greenblatt, R.B., Mahesh, V.B. and Faucher, G.L. Le Syndrome de Stein-Leventhal Est-II Une Entite? Gynecologie Practique 1:35-50, 1967. 59. Mahesh, V.B., Greenblatt, R.B. and Coniff, R.F. Urinary Steroid Excretion Before and After Dexamethasone Administration and Steroid Content of Adrenal Tissue and Venous Blood in Virilizing Adrenal Tumors. Am. J. Obstet. Gynecol. 100:1043-1054, 1968. 60. Greenblatt, R.B., Zarate, A. and Mahesh, V.B. Stimulation of Gonadal Function by Clomiphene Citrate. Clin. Endocrinol. 2:630-642, 1968. 61. Mahesh, V.B., Greenblatt, R.B. and Coniff, R.F. Adrenal Hyperplasia - A Case Report of Delayed Onset of the Congential Form or an Acquired Form. J. Clin. Endocrinol. 28:619-623, 1968. 62. Goldman, B.D. and Mahesh, V.B. Fluctuations in Pituitary FSH During the Ovulatory Cycle in the Rat and a Possible Role of FSH in the Induction of Ovulation. Endocrinology 83:97-106, 1968. 63. Goldman, B.D. and Mahesh, V.B. Surge of FSH at the Time of Ovulation and Its Possible Significance. Proceedings of the 3rd International Congress of Endocrinology, Excerpta Med. Int. Congr. Ser. 157:409, 1968. 64. Goldman, B.D. and Mahesh, V.B. A Possible Role of Acute FSH-Release in Ovulation in the Hamster, as Demonstrated by Utilization of Antibodies to LH and FSH. Endocrinology 84:236-243, 1969. 65. Mahesh, V.B. and McDonough, P.G. Urinary Steroid Excretion in a Hirsute Patient with Ovarian Cortical Stromal Hyperplasia and Endometrial Carcinoma. Am. J. Obstet. Gynecol. 104:602-603, 1969. 66. McDonough, P.G., Byrd, J.R. and Mahesh, V.B. Gonadal Dysgenesis with Spontaneous Menses - Report of a Patient Stimulated with HMG and HCG. Fertil. Steril. 20:451-459, 1969. 67. Faucher, G.L., Ellegood, J.O., Mahesh, V.B. and Greenblatt, R.B. Urinary Estrogens and Pregnanediol Before and After Insertion of an Intrauterine Contraceptive Device. Am. J. Obstet. Gynecol. 104:502-507, 1969. 68. Dalla Pria, S., Greenblatt, R.B. and Mahesh, V.B. An Antiandrogen in Acne and Idiopathic Hirsutism. Invest. Dermatol. 52:348-350, 1969. 69. Mahesh, V.B., Dalla Pria, S. and Greenblatt, R.B. Abnormal Lactation with Cushing's Syndrome - A Case Report. J. Clin. Endocr. Metab. 29:978-981, 1969. 70. Ellegood, J.O., Mahesh, V.B. and Greenblatt, R.B. Chorionic Gonadotropin Tests for the Diagnosis of Pregnancy and Chorionic Tumors. Postgrad. Med. 46:105-109, 1969. 71. McDonough, P.G., Mahesh, V.B. and Byrd, J.R. Gonadotropins. Fertil. Steril. 21:126-133, 1970. The Diagnostic Use of 72. Goldman, B.D. and Mahesh, V.B. Induction of Infertility in Male Rats by Treatment with Gonadotropin Antiserum During Neonatal Life. Biol. Reprod. 2:444-452, 1970. 73. Mahesh, V.B., McDonough, P.G. and Deleo, C.A. Endocrine Studies in the Arrhenoblastoma. Am. J. Obstet. Gynecol. 107:183-187, 1970. 74. Servy, E., Greenblatt, R.B., Scholer, H.F.L. and Mahesh, V.B. Clomiphene et de ses Isomeres. Gynecologic Pratique, 6:453-466, 1970. L'Histoire du 75. Goldman, B.D., Mahesh, V.B. and Porter, J.C. The Role of the Ovary in Control of Cyclic LH Release in the Hamster, Mesocricetus auratus. Biol. Reprod. 4:57-65, 1971. 76. Dmowski, W.P., Scholer, H.F.L., Mahesh, V.B. and Greenblatt, R.B. Danazol – A Synthetic Steroid Derivative with Interesting Physiologic Properties. Fertil. Steril. 22:9-18, 1971. 77. Greenblatt, R.B., Dmowski, W.P., Scholer, H.F.L. and Mahesh, V.B. Clinical Studies with an Antigonadotropin - Danazol. Fertil. Steril. 22:102-112, 1971. 78. Gambrell, R.D., Greenblatt, R.B. and Mahesh, V.B. Post-Pill and Pill-Related Amenorrhea- Galactorrhea. Am. J. Obstet. Gynecol. 110:838-848, 1971. 79. Mahesh, V.B. Current Concepts on the Regulation of Ovulation and Corpus Luteum Function. J. Reprod. Fertil. 27:297-298, 1971. 80. Gambrell, R.D., Greenblatt, R.B. and Mahesh, V.B. Serum Gonadotropins Levels and Ancillary Studies in Stein-Leventhal Syndrome Treated with Clomiphene Citrate. Obstet. Gynecol. 38:850-862, 1971. 81. Mahesh, V.B. and Goldman, B.D. Secretion of FSH and LH during the Ovulatory Cycle and Their Role in the Induction of Ovulation and Corpus Luteum Function. In: Hormonal Steroids. Excerpta Med. Int. Congr. Ser. 219:662-669, 1972. 82. Greenblatt, R.B., Mahesh, V.B. and Gambrell, R.D. Arrhenoblastoma - Three Case Reports. Obstet. Gynecol. 39:567-576, 1972. 83. McDonough, P.G., Mahesh, V.B. and Ellegood, J.O. Steroid and Follicle-Stimulating Hormone, and Luteinizing Hormone Profiles in Identical Twins with Polycystic Ovaries. Am. J. Obstet. Gynecol. 113:1072-1077, 1972. 84. Gambrell, R.D., Greenblatt, R.B. and Mahesh, V.B. Serum Gonadotropins in a Variety of Anovulatory Women Treated with Clomiphene Citrate. Int. J. Gynecol. Obstet. 11:90-95, 1973. 85. Gambrell, R.D., Greenblatt, R.B. and Mahesh, V.B. Inappropriate Secretion of LH in the Stein-Leventhal Syndrome. Obstet. Gynecol. 42:429-440, 1973. 86. Baranczuk, R., Muldoon, T.G. and Mahesh, V.B. Progesterone Measurement Using "Stripped" Corticosteroid Binding Globulin (CBG). Steroids 22:273-284, 1973. 87. Eldridge, J.C., Dmowski, W.P. and Mahesh, V.B. Effects of Castration of Immature Rats on Serum FSH and LH, and of Various Steroid Treatments After Castration. Biol. Reprod. 10:438-446, 1974. 88. Carr, A.A. and Mahesh, V.B. Steroids 5:119- 131, 1974. Control of Aldosterone Secretion. Research on 89. Eldridge, J.C. and Mahesh, V.B. The Pituitary-Gonadal Axis Before Puberty: Evaluation of Testicular Steroids in the Male Rat. Biol. Reprod. 11:385-397, 1974. 90. Eldridge, J.C., McPherson, J.C. and Mahesh, V.B. Maturation of the Negative Feedback Control of Gonadotropin Secretion in the Female Rat. Endocrinology 94:1536-1540, 1974. 91. Mahesh, V.B. and Knudsen, J.F. Effect of Androgens on Ovulation. Contemp. Obstet. Gynecol. 3:15-21, 1974. 92. McPherson, J.C., III, Costoff, A., Eldridge, J.C. and Mahesh, V.B. Effect of Various Progestational Preparations on Gonadotropin Secretion in Ovariectomized Immature Female Rats. Fertil. Steril. 25:1063-1070, 1974. 93. Mills, T.M., Lin, T.J., Hernandez-Ayup, S., Greenblatt, R.B., Ellegood, J.O. and Mahesh, V.B. The Metabolic Clearance Rate (MCR) and Urinary Excretion of Oral Contraceptive Drugs I. Norethindrone. Am. J. Obstet. Gynecol. 120:764-772, 1974. 94. Mills, T.M., Lin, T.J., Hernandez-Ayup, S., Greenblatt, R.B., Ellegood, J.O. and Mahesh, V.B. The Metabolic Clearance Rate (MCR) and Urinary Excretion of Oral Contraceptive Drugs II. Mestranol. Am. J. Obstet. Gynecol. 120:773-778, 1974. 95. Costoff, A., Eldridge, J.C. and Mahesh, V.B. Pituitary Ultrastructure and Serum Gonadotropin Levels in the PMS-Primed Immature Rat. Cell Tissue Res. 151:79-92, 1974. 96. Costoff, A., Knudsen, J.F. and Mahesh, V.B. Correlation of Serum Gonadotropins, Ovarian and Uterine Histology in Immature and Prepubertal Rats. Anat. Rec. 180:497-507, 1974. 97. Parker, C.R., Jr., Servy, E., McDonough, P.G. and Mahesh, V.B. In Vivo Endocrine Studies in the Adrenal Rest Tumor of the Ovary. Obstet. Gynecol. 44:327-332, 1974. 98. McPherson, J.C., III, Costoff, A. and Mahesh, V.B. The Pituitary-Gonadal Axis Before Puberty: Effects of Various Estrogenic Steroids in the Ovariectomized Rat. Steroids 24:41-56, 1974. 99. Greenblatt, R.B. and Mahesh, V.B. Some New Thoughts on the Stein-Leventhal Syndrome. J. Reprod. Med. 13:85-88, 1974. 100. Greeley, G.H., Jr., Allen, M.B. and Mahesh, V.B. FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH. Proc. Soc. Expl. Biol. Med. 147:859-862, 1974. 101. Mahesh, V.B., McPherson, James C., III, Costoff, A. and Eldridge, C.J. Effects of Various Progestational Preparations on Gonadotropin Secretion in Ovariectomized Immature Female Rats. Fertil. Steril. 25:1063-1070, 1974. 102. Cidlowski, J.A., Black, J.B., Muldoon, T.G. and Mahesh, V.B. Development of Thyroidal Responsiveness to Estrogen in the Maturing Rat (38471). Proc. Soc. Expl. Biol. Med. 148:33-36, 1975. 103. Parker, C.R., Jr., Ellegood, J.O. and Mahesh, V.B. Comparative Evaluation of Antisera for 5"-Dihydrostestosterone Radioimmunoassay. J. Steroid Biochem. 6:9-13, 1975. 104. Parker, C.R., Jr., Ellegood, J.O. and Mahesh, V.B. Methods for Multiple Steroid Radio-immunoassay. J. Steroid Biochem. 6:1-8, 1975. 105. Costoff, A. and Mahesh, V.B. Primordial Follicles with Normal Oocytes in the Ovaries of Postmenopausal Women. J. Am. Geriatr. Soc. 23:193-196, 1975. 106. Oettinger, M., Psaroudakis, A., Mahesh, V.B. and Greenblatt, R.B. Effect of LHRH Stimulation in Anovulatory Women. Obstet. Gynecol. 45:614-618, 1975. 107. Mahesh, V.B., Muldoon, T.G., Eldridge, C.J. and Korach, K.S. The Role of Steroid Hormones in the Regulation of Gonadotropin Secretion. J. Steroid Biochem. 6:1025-1036, 1975. 108. Knudsen, J.F. and Mahesh, V.B. Initiation of Precocious Sexual Maturation in the Immature Rat Treated With Dehydroepiandrosterone. Endocrinology 97:458-468, 1975. 109. McPherson, J.C., Costoff, A. and Mahesh, V.B. Influence of Estrogen-Progesterone Combinations on Gonadotropin Secretion in Castrate Female Rats. Endocrinology 97:771-779, 1975. 110. Knudsen, J.F., Costoff, A. and Mahesh, V.B. Dehydroepiandrosterone-Induced Polycystic Ovaries and Acyclicity in the Rat. Fertil. Steril. 26:807-817, 1975. 111. Parker, C.R., Bruneteau, D.W., Greenblatt, R.B. and Mahesh, V.B. Peripheral, Ovarian, and Adrenal Vein Steroids in Hirsute Women: Acute Effects of Human Chorionic Gonadotropin and Adrenocorticotrophic Hormone. Fertil. Steril. 26:877-888, 1975. 112. Mahesh, V.B. Current Status of Luteinizing Hormone-Releasing Hormone in Diagnosis and Treatment of Disorders in Reproductive Function. J. Reprod. Med. 15:145-151, 1975. 113. Greeley, G.H., Jr., Allen, M.B., Jr. and Mahesh, V.B. Potentiation of Luteinizing Hormone Release by Estradiol at the Level of the Pituitary. Neuroendocrinology, 18:233-241, 1975. 114. Greeley, G.H., Jr., Muldoon, T.G. and Mahesh, V.B. Correlative Aspects of Luteinizing Hormone-Releasing Hormone Sensitivity and Cytoplasmic Estrogen Receptor Concentration in the Anterior Pituitary and Hypothalmus of the Cycling Rat. Biol. Reprod. 13:505-512, 1975. 115. McDonough, P.C., Ellegood, J.O., Byrd, J.R. and Mahesh, V.B. Ovarian and Peripheral Venous Steroids in XY Gonadal Dysgenesis and Gonadoblastoma. Obstet. Gynecol. 47:351-355, 1976. 116. Parker, C.R., Jr., Costoff, A., Muldoon, T.G. and Mahesh, V.B. Actions of Pregnant Mare Serum Gonadotropin in the Immature Female Rat: Correlative Changes in Steroids, Gonado-tropins, and Cytoplasmic Estradiol Receptors of the Anterior Pituitary and Hypothalamus. Endocrinology 98:129-138, 1976. 117. Parker, C.R., Jr. and Mahesh, V.B. Hormonal Events Surrounding the Natural Onset of Puberty in Female Rats. Biol. Reprod. 14:347-353, 1976. 118. Greenblatt, R.B., Colle, M.S. and Mahesh, V.B. Ovarian and Adrenal Steroid Production in the Postmenopausal Woman. Obstet. Gynecol. 47:383-387, 1976. 119. Greenblatt, R.B. and Mahesh, V.B. The Androgenic Polycystic Ovary. Am. J. Obstet. Gynecol. 125:712-726, 1976. 120. Greenblatt, R.B. and Mahesh, V.B. Interrelationship Between Excessive Levels of Circulating Androgens in Blood and Ovulatory Failure. J. Reprod. Med. 17:75-90, 1976. 121. Mills, T.M., Lin, T.J., Braselton, W.E., Jr., Ellegood, J.O. and Mahesh, V.B. Metabolism of Oral Contraceptive Drugs. The Formation and Disappearance of Metabolites of Norethindrone and Mestranol After Intravenous and Oral Adminstration. Am. J. Obstet. Gynecol. 126: 987-992, 1976. 122. Bhalla, V.K., Haskell, J., Grier, H. and Mahesh, V.B. Gonadotropin Binding Factor(s). Extraction of High Affinity Gonadotropin Binding Sites from Rat Testis and Partial Characterization of their Interaction with Human Follitropin, Lutropin and Chorio-gonadotropin. J. Biol. Chem. 251:4947-4957, 1976. 123. Parker, C.R., Jr. and Mahesh, V.B. Dehydroepiandrosterone (DHA) Induced Precocious Ovulation: Correlative Changes in Blood Steroids, Gonadotropins and Cytosol Estradiol Receptors of Anterior Pituitary Gland and Hypothalamus. J. Steroid Biochem. 8:173-177, 1977. 124. Braselton, W.E., Lin, T.J., Mills, T.M., Ellegood, J.O. and Mahesh, V.B. Identification and Measurement by Gas Chromatography-Mass Spectrometry of Norethindrone and Metabolites in Human Urine and Blood. J. Steroid Biochem. 8:9-18, 1977. 125. Greenblatt, R.B., Asch, R. H., Mahesh, V.B. and Bryner, J.R. Implantation of Pure Crystalline Pellets of Estradiol for Conception Control. Am. J. Obstet. Gynecol. 127:520-524, 1977. 126. McDonough, P.G., Byrd, J.R., Tho, P.T. and Mahesh, V.B. Phenotypic and Cytogenetic Findings in Eighty-Two Patients with Ovarian Failure-Changing Trends. Fertil. Steril. 28: 638-641, 1977. 127. Costoff, A., Greeley, G.H., Jr., Allen, M.B. and Mahesh, V.B. Ultrastructural and Physiological Studies of the Stalk-Sectioned Rat Pituitary Gland. Am. Surg. 3:351-362, 1977. 128. Abney, T.O., Grier, H. and Mahesh, V.B. Estradiol Binding Capacity in the Cryptorchid Rat Testis. Endocrinology 101:975-983, 1977. 129. Nagamani, M., Lin, T.J., McDonough, P.G., Watatani, H., McPherson, J.C. and Mahesh, V.B. Clinical and Endocrine Studies in Menopausal Women After Estradiol Pellet Implantation. Obstet. Gynecol. 50:541-547, 1977. 130. McPherson, J.C., III., Costoff, A. and Mahesh, V.B. Effects of Aging on the Hypothalamic- Hypophyseal-Gonadal Axis in Female Rats. Fertil. Steril. 28:1365-1370, 1977. 131. Mahesh, V.B., Toledo, S.P.A. and Mattar, E. Hormone Levels Following Wedge Resection in Polycystic Ovary Syndrome. Obstet. Gynecol. 51:64-69, 1978. 132. Greeley, G.H., Jr., Ildemaro, J. V. and Mahesh, V.B. Direct Effect of Estradiol Benzoate and Testosterone on the Response of the Male Rat Pituitary to Luteinizing Hormone Releasing Hormone (LHRH). Biol. Reprod. 18:256-263, 1978. 133. Ward, R.C., Costoff, A. and Mahesh, V.B. The Induction of Polycystic Ovaries in Mature Cycling Rats by the Administration of Dehydroepiandrosterone (DHA). Biol. Reprod. 18:614-623, 1978. 134. Nagamani, M., McDonough, P.G., Ellegood, J.O. and Mahesh, V.B. Maternal and Amniotic Fluid 17"-Hydroxyprogesterone Levels During Pregnancy: Diagnosis of Congenital Adrenal Hyperplasia in Utero. Am. J. Obstet. Gynecol. 130:791-794, 1978. 135. Asch, A.H., Greenblatt, R.B. and Mahesh, V.B. Pure Crystalline Estradiol Pellet Implantation for Contraception. Intern. J. Fertil. 23:100- 105, 1978. 136. Greeley, G.H., Jr. and Mahesh, V.B. Triiodothyronine (T3) Modulation of Gonadotropin Secretion in the Female Rat. Endocr. Res. Commun. 5:135-159, 1978. 137. Braselton, W.E., Jr., Lin, T.J., Ellegood, J.O., Mills, T.M. and Mahesh, V.B. Accumulation of Norethindrone and Individual Metabolites in Human Plasma During Short- and Long-Term Administration of a Contraceptive Dosage. Am. J. Obstet. Gynecol. 133:154-160, 1979. 138. McPherson, J.G., III. and Mahesh, V.B. Dose Related Effect of a Single Injection of Progesterone on Gonadotropin Secretion and Pituitary Sensitivity to LHRH in Estrogen-Primed Castrate Female Rats. Biol. Reprod. 20:763-772, 1979. 139. Mahesh, V.B. and Nazian, S.J. Role of Sex Steroids in the Initiation of Puberty. Journal Steroid Biochem. 11:587-591, 1979. 140. O'Conner, J.L., Allen, M.B. and Mahesh, V.B. Evaluation of In Vitro Incubation Systems for the Study of Gonadotropin Release. Endocr. Res. Commun. 6:15-36, 1979. 141 .Nagamani, M., McDonough, P.G., Ellegood, J.O. and Mahesh, V.B. Maternal and Amniotic Fluid Steroids Throughout Human Pregnancy. Am. J. Obstet. Gynecol. 134:674-680, 1979. 142. Nazian, S.J. and Mahesh, V.B. Alterations in End Organ Responsiveness to Testosterone During the Sexual Maturation of the Male Rat. Biol. Reprod. 21:465-471, 1979. 143. Nazian, S.J. and Mahesh, V.B. Sexual Maturation of the Male Rat. Influence of Androgens on the Pituitary Response to Single or Multiple Injections of LH-RH. Neuroendocrinology 29:313-322, 1979. 144.Bryner, J.R., Greenblatt, R.B., Ellegood, J.O. and Mahesh, V.B. Serum Levels of Estrone and Estradiol after Implantation of Estradiol Pellets. So. Med. 72:711-714, 1979. 145.Vasquez, J.M., Nazian, S.J. and Mahesh, V.B. Pituitary Sensitivity to LHRH in Hyper-prolactinemia Induced by Perphenazine and Renal Pituitary Transplant in Female Rats. Biol. Reprod. 22:486-492, 1980. 146. Nazian, S.J. and Mahesh, V.B. Delay in Some Aspects of the Sexual Maturation of the Male Rat Induced by Androstenedione. Biol. Reprod. 22:451-458, 1980. 147. Nazian, S.J. and Mahesh, V.B. Hypothalamic, Pituitary, Testicular, and Secondary Organ Functions and Interactions During the Sexual Maturation of the Male Rat. Arch. Androl. 4:283-303, 1980. 148. Poole, Max C., Mahesh, V.B. and Costoff, A. Intracellular Dynamics in Pituitary Mammotropes Throughout the Rat Estrous Cycle. I. Morphometric Methodology and Hormonal Correlations with Cellular and Nuclear Volumes. Am. J. Anat. 158:3-13, 1980. 149. Poole, M.C., Mahesh, V.B. and Costoff, A. Intracellular Dynamics in Pituitary Mammotropes Throughout the Rat Estrous Cycle. II. Changes in Synthetic and Secretory Organelles. Am. J. Anat. 158:15-28, 1980. 150. Grier, H.J., Horner, J. and Mahesh, V.B. The Morphology of Enclosed Testicular Tubules in a Teleost Fish, Poecilia Latipinna. Trans. Amer. Micros. Soc. 99:268-276, 1980. 151. O'Conner, J.L., Allen, M.B. and Mahesh, V.B. Castration Effects on the Response of Rat Pituitary Cells to Luteinizing Hormone-Releasing Hormone: Retention in Dispersed Cell Culture. Endocrinology 106:1706-1714, 1980. 152. Nazian, S.J. and Mahesh, V.B. LH-Induced Testicular Steroid Secretion After FSH Treatment in Immature and Young Adult Hypophysectomized Male Rats. Arch. Androl. 6:33-38, 1981. 153. Mahesh, V.B. The Endocrine Changes That Add Up To Puberty. Contemp. Obstet. Gynecol. 18:97-104, 1981. 154. Natrajan, P.K., Muldoon, T.G., Greenblatt, R.B. and Mahesh, V.B. Estradiol and Progesterone Receptors in Estrogen-Primed Endometrium. Am. J. Obstet. Gynecol. 140:387-392, 1981. 155. Manganiello, P.D., Nazian, S.J., Ellegood, J.O., McDonough, P.G. and Mahesh, V.B. Serum Progesterone, 17"-Hydroxyprogesterone, Human Chorionic Gonadotropin and Prolactin in Early Pregnancy and A Case of Spontaneous Abortion. Fertil. Steril. 36:55-60, 1981. 156. Poole, M.C., Mahesh, V.B. and Costoff, A. Morphometric Analysis of the Autophagic and Crinophagic Lysosomal Systems in Mammatropes Throughout the Estrous Cycle of the Rat. Cell and Tissue Research 220:131-137, 1981. 157. O'Conner, J.L., Wolfe, R.R., Allen, M.B. and Mahesh, V.B. Effect of Neonatal Andro-genization on the LHRH Response of Dispersed Pituitary Cell Cultures. Arch. Androl. 8:29-35, 1982. 158. Natrajan, P.K., Muldoon, T.G., Greenblatt, R.B. and Mahesh, V.B. Effect of Progestins on Estrogen and Progesterone Receptors of the Human Endometrium. J. Reprod. Med. 27: 227-230, 1982. 159. Bagnell, C.A., Mills, T.M., Costoff, A. and Mahesh, V.B. A Model for the Study of Androgen Effects on Follicular Atresia and Ovulation. Biol. Reprod. 27:903-914, 1982. 160. Gantt, P.A., Tho, P.T., Bhalla, V.K., McDonough, P.G., Costoff, A. and Mahesh, V.B. Effect of Ethanol Containing Liquid Diet Gonadotropin Receptor Depletion in Rat Testis. J. Pharmacol. Exp. Ther. 223:848-853, 1982. 161 .McPherson, J.C., III. and Mahesh, V.B. Induction of LH and FSH Surge in the Estrogen- Primed Castrated Male Rat by Progesterone. Biol. Reprod. 27:1222-1229, 1982. 162. Smanik, E.J., Young, H.K., Muldoon, T.G. and Mahesh, V.B. Analysis of the Effect of Progesterone In Vivo on Estrogen Receptor Distribution in the Rat Anterior Pituitary and Hypothalamus. Endocrinology 113:15-22, 1983. 163. Murphy, L.L. and Mahesh, V.B. Selective Release of FSH by 5alpha-Dihydroprogesterone in Immature Ovariectomized Estrogen-Primed Rats. Biol. Reprod. 30:594-602, 1984. 164. Murphy, L.L. and Mahesh, V.B. Selective Release of Luteinizing Hormone by 3alpha-Hydroxy- 5-alpha-Pregnane in Immature Ovariectomized Estrogen Primed Rats Biol. Reprod. 30:795-803, 1984. 165. O'Conner, J.L., Lapp, C.A. and Mahesh, V.B. Peptidase Activity in the Hypothalamus and Pituitary of the Rat: Fluctuations and Possible Regulatory Role of Luteinizing Hormone Releasing Hormone-Degrading Activity During the Estrous Cycle. Biol. Reprod. 30:855-862, 1984. 166. El Ayat, Ahamed A.B. and Mahesh, V.B. Stimulation of 17-Beta Hydroxy-Steroid Dehydrogenase in the Rat Anterior Pituitary Gland by Progesterone. J. Steroid Biochem. 20:1141-1145, 1984. 167. Bransome, E.D., Jr., Hendry, L.B., Muldoon, T.G., Mahesh, V.B., Hutson, M.S. and Campbell, L.K. Apparent Stereochemical Complementarity of Estrogens and Helical Cavities Between DNA Base Pairs: Implications for the Mechanism of Action of Steroids. Journal of Theoretical Biology 112:97-108, 1985. 168. Peduto, J.C. and Mahesh, V.B. Effects of Progesterone on Hypothalamic and Plasma LHRH. Neuroendocrinology 40:238-245, 1985. 169. Reindollar, R.H., Moretuzzo, R.W., Ellegood, J.O., Mahesh, V.B. and McDonough, P.G. The Effects of Single-Dose LHRH on Ovulatory Menstrual Function: Support for a Single LH- and FSH-Releasing Factor. Fertil. Steril. 43:185-195, 1985. 170. Murphy, L.L. and Mahesh, V.B. Selective Release of FSH and LH by 5alpha-Dihydroprogesterone and 3-alpha,5-alpha-Tetrahydroprogesterone in Pregnant Mare's Serum Gonadotropin-primed Immature Rats Exposed to Constant Light. Biol. Reprod. 32:795-803, 1985. 171. Mahesh, V.B. The Dynamic Interaction Between Steroids and Gonadotropins in the Mammalian Ovulatory Cycle. Neurosci. Biobehav. Rev. 9:245-260, 1985. 172. Ganapathy, M.E., Mahesh, V.B., Devoe, L.D., Leibach, F.H. and Ganapathy, V. Dipeptide transport in brush-border membrane vesicles isolated from normal term human placenta. Am. J. Obstet. Gynecol. 153:83-86, 1985. 173. Uberoi, N.K., Hendry, L.B., Muldoon, T.G., Myers, R.B., Segaloff, A., Bransome, E.D. and Mahesh, V.B. Structure-Activity Relationships of Some Unique Estrogens Related to Estradiol are Predicted by Fit Into DNA. Steroids 45:325-340, 1985. 174. Vasquez, J.M., Ben-Nunn, I., Greenblatt, R.B., Mahesh, V.B. and Keel, B.A. Correlation Between FSH, LH, Prolactin and Testosterone with Sperm Cell Concentration and Motility. Am. J. Obstet. Gynecol. 67:87-90, 1986. 175. Mills, T.M. and Mahesh, V.B. Gonadotropin Secretion in Polycystic Ovarian Syndrome and Related Diseases. Seminars in Reprod. Endocrinology 4:109-113, 1986. 176. Mahesh, V.B. and Mills, T.M. Pathogenesis of the Polycystic Ovary: Use of an Animal Model for Study. Seminars in Reprod. Endocrinology 4:115-122, 1986. 177. Hendry, L.B., Bransome, Jr., E.D., Lehner, A.F., Muldoon, T.G., Hutson, M.S. and Mahesh, V.B. The Stereochemical Complementarity of DNA and Reproductive Steroid Hormones Correlates with Biological Activity. Journal Steroid Biochem. 24:843-852, 1986. 178. Ganapathy, M.E., Leibach, F.H., Mahesh, V.B., Howard, J.C., Devoe, L.D. and Ganapathy, V. Characterization of Tryptophan Transport in Human Placental Brush-Border Membrane Vesicles. J. Biochem. 238:201-208, 1986. 179. Ganapathy, V., Balkovetz, D.F., Miyamoto, Y., Ganapathy, M.E. and Mahesh, V.B. Inhibition of Human Placental Na+-H+ Exchanger by Cimethidine. J. Pharm. Exper. Ther. 239:192-197, 1986. 180. Ganapathy, M.E., Leibach, F.H., Mahesh, V.B., Devoe, L.D. and Ganapathy, V. Interaction of Clonidine with Human Placental Na+-H+ Exchanger. Biochem. Pharm. 35:3989-3994, 1986. 181.Balkovetz, D.F., Leibach, F.H., Mahesh, V.B., Devoe, L.D., Gragoe, E.J. and Ganapathy, V. Na+-H+ Exchanger of Human Placental Brush-Border Membrane: Identification & Charac-terization. Am. J. Physiol. 251:C852-C860, 1986. 182. Padilla, S.L., Galle, P.C., Ellegood, J.O., Mahesh, V.B. and McDonough, P.G. Plasminogen in Peritoneal Fluid: A Possible Nonsteroidal Indicator of Ovulation. Fert. Steril. 46:1071-1076, 1986. 183. Rao, I.M. and Mahesh, V.B. Role of Progesterone in the Modulation of the Preovulatory Surge of Gonadotropins and Ovulation in the Pregnant Mare's Serum Gonadotropin-Primed Immature Rat and the Adult Rat. Biol. Reprod. 35:1154-1161, 1986. 184. Calderon, J.J., Muldoon, T.G. and Mahesh, V.B. Receptor Mediated Interrelationship Between Progesterone and Estradiol Action on the Anterior Pituitary-Hypothalamic Axis of the Ovariectomized Immature Rat. Endocrinology 120:2428-2435, 1987. 185. Lehner, A.F., Muldoon, T.G., Mahesh, V.B., Bransome Jr., E.D. and Hendry, L.B. Initial Studies of a Phytoestrogen-Deoxyribonucleic Acid Interaction. Molecular Endocrinology 1: 377-387, 1987. 186. Ganapathy, V., Balkovetz, D.F., Ganapathy, M.E., Mahesh, V.B., Devoe, L.D. and Leibach, F.H. Evidence for Histidyl and Carboxy Groups at the Active Site of the Human Placental Na+-H+ Exchanger. Biochem. J. 245:473-477, 1987. 187. Balkovetz, D.F., Miyamoto, Y., Tiruppathi, C., Mahesh, V.B., Leibach, F.H. and Ganapathy, V. Inhibition of Brush-Border Membrane Na+-H+ Exchanger by Loperamide. J. Pharm. Exper. Ther. 243:150-154, 1987. 188.Mahesh, V.B. and Muldoon, T.G. Integration of the Effects of Estradiol and Progesterone in the Modulation of Gonadotropin Secretion. J. Steroid Biochem. 27:665-675, 1987. 189. Greenblatt, R.B., Mahesh, V.B. and Sullivan, D. Gross Cystic Disease of the Breast. Maturitas 9:171-181, 1987. 190. Ganapathy, V., Ganapathy, M.E., Tiruppathi, C., Miyamoto, Y., Mahesh, V.B. and Leibach, F.H. Sodium-Gradient-Driven, High-Affinity, Uphill Transport of Succinate in Human Placental Brush-Border Membrane Vesicles. Biochem J. 249:179-184, 1988. 191. O'Conner, J.L. and Mahesh, V.B. A Possible Role for Progesterone in the Preovulatory Gonadotropin Surge Through Modulation of LHRH Degrading Activity. J. Steroid Biochem. 29:257-264, 1988. 192. Ganapathy, V., Ganapathy, M.E., Nair, C.N., Mahesh, V.B. and Leibach, F. Evidence for an organic cation-proton antiport system in brush-border membranes isolated from the human term placenta. J. Biol. Chemistry 263:4561-4568, 1988. 193. Miyamoto, Balkovetz, D.F., Leibach, F., Mahesh, V.B. and Ganapathy, V. (Na+-Cl-) gradient-driven, high-affinity, uphill transport of taurine in human placental brush-border membrane vesicles. FEBS Letters 231:263-267, 1988. 194. Sridaran, R. and Mahesh, V.B. Inhibitory effects of a gonadotropin-releasing hormone agonist on the luteal synthesis of progesterone, estradiol receptors, and prolactin surges during early pregnancy. Endocrinology 123:1740-1746, 1988. 195. Brann, D.W., Rao, I.M. and Mahesh, V.B. Antagonism of estrogen-induced prolactin release by progesterone. Biol. Reprod. 39:1067-1073, 1988. 196. Balkovetz, D.F., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. A Proton Gradient is the Driving Force for Uphill Transport of Lactate in Human Placental Brush-border Membrane Vesicles. Biochem J. 263:13823-13830, 1988. 197.Abney, T.O., Teran, A.Z., Mahesh, V.B., Mullins, W.B. and Greenblatt, R.B. Fibrocystic Breast Disease: The Significance of Beta-hCG and Other Polypeptides in Breast Cyst Fluid. Fertility and Sterility 49:638-643, 1988. 198. Sridaran, R. and Mahesh, V.B. Suppression of luteal estradiol receptors and progesterone synthesis by a gonadotropin-releasing hormone agonist [WY-40972] during midgestation. Biol. Reprod. 40:276-282, 1989. 199. Balkovetz, D.F., Tirruppathi, C., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. Evidence for an Imipramine-sensitive Serotonin Transporter in Human Placental Brush-border Membranes. Biochem J. 264:2195-2198, 1989. 200. Brann, D., Putnam, C. and Mahesh, V.B. Antagonism of Estrogen-induced Prolactin Release by Dihydrotesterone. Biol. Reprod. 40:1201-1208, 1989. 201. Smanik, E., Calderon, J., Muldoon, T.G. and Mahesh, V.B. Effect of Progesterone on the Activity of Occupied Nuclear Estrogen Receptor In Vitro. Molecular and Cellular Endocrinology 64:111-117, 1989. 202. Kulanthaivel, P.K., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. Tyrosine Residues are Essential for the Activity of the Human Placental Taurine Transporter. Biochemica et Biophysica Acta 985:139-146, 1989. 203. Ganapathy, V., Kulanthaivel, P., Tiruppathi, C., Mahesh, V.B. and Leibach, F.H. Inactivation of the Human Placental Serotonin Transporter by Tyrosyl Group-Specific Reagents. The Journal of Pharmacology and Experimental Therapeutics 251:9-15, 1989. 204. Brann, D.W., Putnam, C.D. and Mahesh, V.B. Corticosteroid Regulation of Gonadotropin and Prolactin Secretion in the Rat. Endocrinology 126:159-166, 1990. 205. Kulanthaivel, P., Leibach, F., Mahesh, V., Cragoe, E. and Ganapathy, V. The Na+-H+ Exchanger of the Placental Brush-border Membrane Is Pharmacologicaly Distinct from That of the Renal Brush-border Membrane*. Journal of Biological Chemistry 265:1249-1252, 1990. 206. Brann, D.W., Putnam, C.D. and Mahesh, V.B. Corticosteroid Regulation of Gonadotropin Secretion and Induction of Ovulation in the Rat. Proceedings of the Society for Experimental Biology and Medicine 193:176-180, 1990. 207. Brann, D.W., Putnam, C.D. and Mahesh, V.B. GABAA Receptor Mediate 3alpha-Hydroxy-5-alpha-Pregnan-20-one Induced Gonadotropin Secretion. Endocrinology 126:1854-1859, 1990. 208. Brann, D.W., Putnam, C.D. and Mahesh, V.B. Dose-Related Effects of Progesterone and 5 Alpha-Dihydroprogesterone upon Estrogen-Induced Prolactin Release. Journal of Neuroendocrinology 2:341-345, 1990. 209. Fuentes, M.A., Muldoon, T.G. and Mahesh, V.B. Role of 17-alpha-hydroxysteroid dehydrogenase in the modulation of nuclear estradiol receptor binding by progesterone in the rat anterior pituitary gland and the uterus. Journal of Steroid Biochemistry and Molecular Biology 37:57-63, 1990. 210. Fuentes, M.A., Muldoon, T.G. and Mahesh, V.B. Inhibitory Effect of 5-Alpha- Dihydroprogesterone on Nuclear Estrogen Receptor Binding of the Anterior Pituitary and Uterus in the Rat. Neuroendocrinology 52:213-220, 1990. 211. Brann, D.W., Putnam, C.D. and Mahesh, V.B. Similarities and differences in progesterone and androgens in modulation of LH, FSH and PRL release: Unexpected properties of flutamide. Journal of Steroid Biochemistry 36:287-294, 1990. 212. Fuentes, M.A., Muldoon, T.G. and Mahesh, V.B. Inhibitory Effect of Progesterone on Occupied Estrogen Receptors of Anterior Pituitary and Uterus in Adult Rats. Journal of Neuroendocrinology 2:517-522, 1990. 213. Conway, B.A., Mahesh, V.B. and Mills, T.M. Effect of dihydrotestosterone on the growth and function of ovarian follicles in intact immature female rats primed with PMSG. Journal of Reproduction and Fertility 90:267-277, 1990. 214. Kulanthaivel, P., Simon, B.J., Burckhardt, G., Mahesh, V.B., Leibach, F.H. and Ganapathy, V. The ATP-Binding Site of the human Placental H+ Pump Contains Essential Tyrosyl Residues. Biochemistry 29:10807-10813, 1990. 215. Brann, D.W. and Mahesh, V.B. Endogenous excitatory amino acid regulation of the progesterone-induced LH and FSH surge in estrogen-primed ovariectomized rats. Neuroendocrinology 53:107-110, 1991. 216. Brann, D.W. and Mahesh, V.B. Validation of the Mechanisms Proposed for the Stimulatory and Inhibitory Effects of Progesterone on Gonadotropin Secretion in the Estrogen-Primed Rat. A Possible Role for Adrenal Steroids. Steroids 56:103-111, 1991. 217. Rao, I.M., Mills, T.M., Anderson, E. and Mahesh, V.B. Heterogeneity in Granulosa Cells of Developing Rat Follicles. The Anatomical Record 229:177-185, 1991. 218. Rao, I.M., Allsbrook, Jr., W.C., Conway, B.A., Martinez, J.E., Beck, J.R., Pantazis, C.G., Mills, T.M., Anderson, E. and Mahesh, V.B. Flow cytometric analysis of granulosa cells from developing rat follicles. Journal of Reproduction and Fertility 91:521-530, 1991. 219. Brann, D.W. and Mahesh, V.B. Endogenous excitatory amino acid involvement in the preovulatory and steroid-induced surge of gonadotropins in the female rat. Endocrinology 128:1541-1547, 1991. 220. Brann, D.W. and Mahesh, V.B. Regulation of gonadotropin secretion by steroid hormones. Frontiers in Neuroendocrinology 12:165-207, 1991. 221. Putnam, C.D., Brann, D.W. and Mahesh, V.B. Acute activation of the ACTH-adrenal axis: Effect upon gonadotropin and prolactin secretion in the female rat. Endocrinology 128: 2558-2566, 1991. 222. Brann, D.W. and Mahesh, V.B. Detailed Examination of the Mechanism and Site of Action of Progesterone and Corticosteroids in the Regulation of Gonadotropin Secretion: Hypothalamic Gonadotropin Releasing Hormone and Catecolamine Involvement. Biology of Reproduction 44:1005-1015, 1991 . 223. Putnam, C.D., Brann, D.W., Kolbeck, R.C. and Mahesh, V.B. Inhibition of uterine contractility by progesterone and progesterone metabolites: Mediation by progesterone and gamma amino butyric acidA receptor systems. Biology of Reproduction 45:246-272, 1991. 224. Brann, D.W. and Mahesh, V.B. The role of corticosteroids in reproduction. The FASEB Journal. (Invited "State of the Art" Review) 5:2691-2698, 1991. 225.Chakravorty, A., Mahesh, V.B. and Mills, T.M. Regulation of follicular development by diethylstilboestrol in the immature rat ovary. Journal of Reproduction and Fertility 92:307- 321, 1991. 226. Chakravorty, A., Mahesh, V.B. and Mills, T.M. Inhibition of proliferative potential of specific-sized follicles in the rat ovary by diethylstilboestrol. Journal of Reproduction and Fertility 92:323-332, 1991. 227. Hendry, L.B. and Mahesh, V.B. Stereochemical complementarity of progesterone and cavities between base pairs in partially unwound double stranded DNA using computer modeling and energy calculations to determine degree of fit. Journal of Steroid Biochemistry and Molecular Biology 39:133-146, 1991. 228. Kulanthaivel, P., Cool, D.R., Ramamoorthy, S., Mahesh, V.B., Leibach, F.H. and Ganapathy, V. Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line. Journal of Biochemistry 277:53-58, 1991. 229. Ramamoorthy, S., Tiruppathi, C., Nair, C., Mahesh, V., Leibach, F. and Ganapathy, V. Relative sensitivity in inhibition by cimetidine and clonidine differentiates between the two types of Na+-H+ exchangers in cultured cells. Biochemistry Journal 280:317-322, 1991. 230. Cool, D.R., Leibach, F.H., Bhalla, V.K., Mahesh, V.B. and Ganapathy, V. Expression and Cyclic AMP-dependent Regulation of a High Affinity Serotonin Transporter in the Human Placental Choriocarcinoma Cell Line (JAR). Journal of Biological Chemistry 266:15750-15757, 1991. 231. Brann, D.W., McDonald, J.K., Putnam, C.D. and Mahesh, V.B. Regulation of hypothalamic gonadotropin-releasing hormone and neuropeptide Y concentrations by progesterone and corticosteroids in immature rats: Correlation with Luteinizing hormone and follicle-stimulating hormone release. Neuroendocrinology 54:425-432, 1991. 232. Zamorano, P., Steinsapir, J. and Mahesh, V.B. Effect of 5"-Dihydrotestosterone and Dexamethasone on Estrogen Receptors of the Anterior Pituitary and the Uterus. Steroids 57:18-26, 1992. 233. Mahesh, V.B. and Brann, D.W. Interaction between ovarian and adrenal steroids in the regulation of gonadotropin secretion. Journal of Steroid Biochemistry and Molecular Biology 41:495-513, 1992. 234. Brann, D.W. and Mahesh, V.B. Excitatory amino acid regulation of gonadotropin secretion: modulation by steroid hormones. Journal of Steroid Biochemistry and Molecular Biology 41:847-850, 1992. 235. Hendry, L.B. and Mahesh, V.B. Stereochemical complementarity of progesterone, RU486 and cavities between base pairs in partially unwound double stranded DNA assessed by computer modeling and energy calculations. Journal of Steroid Biochemistry and Molecular Biology 41:647-651, 1992. 236. Brann, D.W. and Mahesh, V.B. Excitatory amino acid neurotransmission: Evidence for a role in neuroendocrine regulation. Trends in Endocrinology & Metabolism 3:120-124, 1992. 237. Brann, D, O'Conner, J., Wade, M. and Mahesh, V. LH and FSH subunit mRNA concentrations during the progesterone-induced gonadotropin surge in ovariectomized estrogen-primed immature rats. Molecular and Cellular Neurosciences 3:171-178, 1992. 238. Brann, D.W., Putnam-Roberts, C.D. and Mahesh, V.B. Progesterone and corticosteroid regulation of hypothalamic and pituitary opioid content during LH surge induction. Molecular and Cellular Neurosciences 3:191-198, 1992. 239. Brann, D.W., Zamorano, P.L., Putnam-Roberts, C.D. and Mahesh, V.B. Gamma aminobutyric acid-opioid interactions in the regulation of gonadotropin secretion in the immature female rat. Neuroendocrinology 56:445-452, 1992. 240. Lesoon, L.A. and Mahesh, V.B. Stimulatory and inhibitory effects of progesterone on FSH secretion by the anterior pituitary. Journal of Steroid Biochemistry and Molecular Biology 42:479-491, 1992. 241. Hendry, L.B., Muldoon, T.G. and Mahesh, V.B. The metabolic pathways for hormonal steroids appear to be reflected in the stereochemistry of DNA. Journal of Steroid Biochemistry and Molecular Biology 42:659-670, 1992. 242. Putnam-Roberts C., Brann, D.W. and Mahesh, V.B. Role of 5-alpha-reduction in progesterone's ability to release FSH in estrogen-primed ovariectomized rats. Journal of Steroid Biochemistry and Molecular Biology 42:875-882, 1992. 243. Kulanthaivel, P., Furesz, T.C., Moe, A.J., Smith, C.H., Mahesh, V.B., Leibach, F.H. and Ganapathy, V.Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na+-H + exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane. Biochem. J. 284:3338, 1992. 244. Ramamoorthy, S., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. Active transport of dopamine in human placental brush-border membrane vesicles. Am. J. Physiol. 262: C1189-C1196, 1992. 245. Ramamoorthy, S., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. Selective impairment of taurine transport by cyclosporin A in a human placental cell line. Pediatric Research 32:125-127, 1992. 246. Ramamoorthy, S., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. Modulation of the activity of amino acid transport system L by phorbol esters and calmodulin antagonists in a human placental choriocarcinoma cell line. Biochimica et Biophysica Acta 1136:181-188, 1992. 247. Ramamoorthy, S., Cool, D.R., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. Reconstitution of the human placental 5-hydroxytryptamine transporter in a catalytically active form after detergent solubilization. Biochem. J. 286:89-95, 1992. 248. Chorich, L., Rosser, M., Howard, E., Zamorano, P. and Mahesh, V.B. Rat anterior pituitary estrogen receptor mRNA levels after estrogen and progesterone treatment. Molecular and Cellular Neurosciences 3:487-496, 1992. 249. Bhalla, V.K., Behzadian, M.A., George, P.E., Howard, E.F., Mahesh, V.B. and Abney, T.O. Cell specific distribution of LH/hCG receptor messenger ribonucleic acid in rat testicular Leydig cells. Endocrinology 131:2485-2487, 1992. 250. Gao, X., Greenbaum, L., Mahesh, V. and Brann, D. Characterization of the kinin system in the ovary during ovulation in the rat. Biology of Reproduction 47:945-951, 1992. 251. Prasad, P.D, Leibach, F.H., Mahesh V.B. and Ganapathy, V. Specific interaction of 5-(N-Methyl-N-isobutyl) amiloride with the organic cation-proton antiporter in human placental brush-border membrane vesicles. J. Biol. Chem. 267:23632-23639, 1992. 252. Rosser, M., Chorich, L., Howard, E., Zamorano, P. and Mahesh, V.B. Changes in rat uterine estrogen receptor mRNA levels during estrogen and progesterone induced estrogen receptor depletion and subsequent replenishment. Biology of Reproduction 48:89-98, 1993. 253. Simone, D.A. and Mahesh, V.B. An autoregulatory process for androgen production in rat thecal-interstitial cells. Biology of Reproduction 48:46-56, 1993. 254. Brann, D.W., Zamorano, P.L., Ping, L. and Mahesh, V.B. Role of excitatory amino acid neurotransmission during puberty in the female rat. Molecular and Cellular Neurosciences 4: 107-112, 1993. 255. Chakravorty, A., Mahesh, V.B. and Mills, T.M. Oestrogen and gonadotropin control of peptides regulating granulosa cell mitosis in the immature rat ovary. J. of Reproduction and Fertility 97:91-100, 1993. 256. Brann, D.W., Ping, L. and Mahesh, V.B. Possible role of non-NMDA receptormediated neurotransmission in steroid-induced and preovulatory gonadotropin surges in the rat. Molecular and Cellular Neurosciences 4:292-297, 1993. 257. Rao, I.M., Gadson, P.F., Jr., Anderson, E., Hornsby, P.J. and Mahesh, V.B. Characterization of progesterone biosynthesis in a transformed granulosa cell line. Molecular and Cellular Endocrinology 94:121-128, 1993. 258. Ramamoorthy, S., Kulanthaivel, P., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. Solubilization and functional reconstitution of the human placental taurine transporter. Biochemica et Biophysica Acta 1145:250-256, 1993. 259. Brann, D.W., Zamorano, P.L., Chorich, L.P. and Mahesh, V.B. Steroid hormone effects on NMDA receptor binding and NMDA receptor mRNA levels in the hypothalamus and cerebral cortex of the adult rat. Neuroendocrinology 58:666-672, 1993. 260. Brann, D.W., O'Conner, J.L., Wade, M.F., Zamorano, P.L. and Mahesh, V.B. Regulation of anterior pituitary gonadotropin subunit mRNA levels during the preovulatory gonadotropin surge: A physiological role of progesterone in regulating LHbeta and FSH-beta mRNA levels. Journal of Steroid Biochemistry and Molecular Biology 46:427-437, 1993. 261. Copland, J.A., Hendry, L.B., Chu, C.K., Wood, J.C., Wrenn, R.W., Pantazis, C.G. and Mahesh, V.B. Inhibition of estrogen stimulated mitogenesis by 3phenylacetylamino-2, 6-piperidinedione and its para-hydroxy analog. Journal of Steroid Biochemistry and Molecular Biology 46:451-462, 1993. 262. O'Conner, J.L., Wade, M.F., Brann, D.W. and Mahesh, V.B. Direct anterior pituitary modulation of gonadotropin secretion by neuropeptide Y (NPY): Role of gonadal steroids. Neuroendocrinology 58:129-135, 1993. 263. Brann, D.W. and Mahesh, V.B. Role of excitatory amino acids in reproduction. Advances in Contraceptive Delivery Systems 9:176-177, 1993. 264. Mahesh, V.B. and Brann, D.W. Relationship between anterior pituitary estrogen receptor dynamics and the preovulatory gonadotropin surge. Advances in Contraceptive Delivery Systems 9:221-222, 1993. 265. Gao, XX, Greenbaum, L.M., Mahesh, V.B. and Brann, D.W. The kinin system and ovulation. Advances in Contraceptive Delivery Systems 9:223-230, 1993. 266. Zhou, Y., Chorich, L.P., Mahesh, V.B and Ogle, T.F. Regulation of estrogen receptor protein and messenger ribonucleic acid by estradiol and progesterone in rat uterus. Journal of Steroid Biochemistry and Molecular Biology 46:687-698, 1993. 267. Simone, D.A., Chorich, L.P. and Mahesh, V.B. Mechanisms of action for an androgen-mediated autoregulatory process in rat thecal-interstitial cells. Biology of Reproduction 49: 1190-1201, 1993. 268. Bhalla, V.K., Abney, T.O. and Mahesh, V.B. Gonadotropin receptor gene expression in regenerating Leydig cells following a single in vivo injection of ethylene dimethylsulfonate. Endocrine Journal 1:427-434, 1993. 269. Ramamoorthy, S., Leibach, F.H., Mahesh, V.B and Ganapathy, V. Partial purification and characterization of the human placental serotonin transporter. Placenta 14:449-461, 1993. 270. Ramamoorthy, S., Cool, D.R., Mahesh, V.B., Leibach, F.H., Melikian, H.E., Blakely, R.D. and Ganapathy, V. Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. Journal of Biological Chemistry 268:21626-21631, 1993. 271. Jayanthi, L.D., Prasad, P.D., Ramamoorthy, S., Mahesh, V.B., Leibach, F.H. and Ganapathy, V. Sodium- and chloride-dependent, cocaine-sensitive, high-affinity binding of nisoxetine to the human placental norepinephrine transporter. Biochemistry 32:1217812185, 1993. 272. Brann, D.W., Chorich, L.P. and Mahesh, V.B. Effect of progesterone on galanin mRNA levels in the hypothalamus and the pituitary: correlation with the gonadotropin surge. Neuroendocrinology 58:531-538, 1993. 273. Ogle, T.F., Soares, M.J., Zhou, Y., Chorich L., and Mahesh, V.B. Regulation of the estrogen receptor and estrogen receptor mRNA in rat Decidua basalis and placenta during pregnancy. Steroid Biochem. (Life Sci. Adv.) 12:1-12, 1993. 274. Brann, D.W., Chorich, L.P., Zamorano, P.L. and Mahesh, V.B. Presence of NMDA receptor mRNA in the anterior pituitary of the female rat: steroid modulation and changes during gonadotropin surge induction. Molecular and Cellular Neurosciences 4:571-575, 1993. 275. Mahesh, V.B. and Brann, D.W. Modulation of the preovulatory gonadotropin surge by progesterone induced changes in anterior pituitary estrogen receptors. Assisted Reproductive Technology/Andrology 5:1-14, 1994. 276. Brann, D.W. and Mahesh, V.B. Neuroendocrine regulation of gonadotropin secretion: Role of excitatory amino acids. Assisted Reproductive Technology/Andrology 5:201-211, 1994. 277. Gao, X.X., Greenbaum, L.M., Mahesh, V.B. and Brann, D.W. Role of kinin system in female reproduction. Assisted Reproductive Technology/Andrology 5:197-199, 1994. 278. Zhou, Y., Mahesh, V.B. and Ogle, T.F. The role of rat uterine microsomal estrogen receptor in ovarian steroid hormone action. Endocrine Journal 2:53-62, 1994. 279. Ping, L., Mahesh, V.B., Wiedmeier, V.T. and Brann, D.W. Release of glutamate and aspartate from the preoptic area during the progesterone-induced LH surge: in vivo microdialysis studies. Neuroendocrinology 59:318-324, 1994. 280. Brann, D.W and Mahesh, V.B. Excitatory amino acids: function and significance in reproduction and neuroendocrine regulation. Invited Review Frontiers in Neuroendocrinology 15: 3-49, 1994. 281. Hendry, L.B., Chu, C.K., Copland, J.A. and Mahesh, V.B. Antiestrogenic piperidinediones designed prospectively using computer graphics and energy calculations of DNA/ligand complexes. J. Steroid Biochem. & Molecular Biology 48:495-505, 1994. 282. Hendry, L.B., Chu, C.K., Rosser, M.L., Copland, J.A., Wood, J.C. and Mahesh, V.B. Design of novel antiestrogens. J. Steroid Biochem. & Molecular Biology 49:269280, 1994. 283. Prasad, P.D., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. Relationship between thyroid hormone transport and neutral amino acid transport in JAR human choriocarcinoma cells. Endocrinology 134:574-581, 1994. 284. Ping, L., Mahesh, V.B. and Brann, D.W. A physiological role for NMDA and nonNMDA receptors in pulsatile gonadotropin secretion in the adult female rat. Endocrinology 135:113-118, 1994. 285. Brann, D.W. and Mahesh, V.B. Role of NMDA and non-NMDA neurotransmission in the induction of puberty and pulsatile LH secretion. Assisted Reproductive Technology/Andrology 6B:11-14, 1994. 286. Mahesh, V.B. and Brann, D.W. Role of estrogens and progesterone in inducing the preovulatory pattern of LH and FSH secretion. Assisted Reproductive Technology/Andrology 6B:18-20, 1994. 287. Jayanthi, L.D., Ramamoorthy S., Mahesh, V.B., Leibach, F.H. and Ganapathy, V. Calmodulin-dependent regulation of catalytic function of the human seratonin transporter in placental choriocarcinoma cells. J. Biol. Chem. 269:14424-14429, 1994. 288. Prasad, P.D., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. Human placenta as a target organ for cocaine action: Interaction of cocaine with the placental seratonin transporter. Placenta 15:267-278, 1994. 289. Steinsapir, J., Mora, G., Muldoon, T.G., Mahesh, V.B. and Hendry, L.B. Androgenic activity of antiandrogens predicted by fit into DNA. Am. J. of Therapeutics 1:236-244, 1994. 290. Brandsch, M., Leibach, F.H., Mahesh, V.B. and Ganapathy, V. Calmodulindependent modulation of pH sensitivity of the amino acid transport system L in human placental choriocarcinoma cells. Biochim. Biophy. Acta. 1192:177-184, 1994. 291. Prasad, P.D., Mahesh, V.B., Leibach, F.H. and Ganapathy, V. Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. Biochim. Biophy. Acta. 1222:309314, 1994. 292. Brann, D.W. and Mahesh, V.B. LH secretion: Control by excitatory amino acids. Assisted Reproductive Technology/Andrology 7:1-8, 1995. 293. Mahesh, V.B. and Brann, D.W. Steroidal regulation of gonadotropin secretion: role of progesterone and adrenal steroids. Assisted Reproductive Technology/Andrology 7:1525, 1995. 294. Brann, D.W., Greenbaum, L., Mahesh, V.B. and Gao, X. Changes in kininogens and kallikrein in the plasma, brain and uterus during pregnancy in the rat. Endocrinology 136:46-51, 1995. 295. Brann, D.W., Hendry, L.B. and Mahesh, V.B. Emerging diversities in the mechanism of action of steroid hormones. (Invited Review) J. Steroid Biochem. & Molec. Biol. 52:113-133, 1995. 296. Ping, L., Mahesh, V.B. and Brann, D.W. Effect of NMDA and non-NMDA receptor antagonists on pulsatile luteinizing hormone secretion in the adult male rat. Neuroendocrinology 61:226-234, 1995. 297. Ramamoorthy, J.D., Ramamoorthy, S., Mahesh, V.B., Leibach, F.H. and Ganapathy V. Cocain-sensitive F-receptor and its interaction with steroid hormones in the human placental syncytiotrophoblast and in choriocarcinoma cells. Endocrinology 136:924-932, 1995. 298. Brann, D.W. and Mahesh, V.B. Glutamate: A major neuroendocrine excitatory signal mediating steroid effects on gonadotropin secretion. J. Steroid Biochem. & Molec. Biol. 53:325-329, 1995. 299. O'Conner, J.L., Wade, M.F., Brann, D.W. and Mahesh, V.B. Evidence that progesterone modulates anterior pituitary neuropeptide Y levels during the progesteroneinduced gonadotropin surge in the estrogen-primed intact immature female rat. J. Steroid Biochem. & Molec. Biol., 52:497-504, 1995. 300. Bhat, G.K., Mahesh, V.B., Zhen, W.C., Chorich, L.P., Zamorano, P.L. and Brann, D.W. Localization of the N-methyl-D-aspartate R1 receptor subunit in specific anterior pituitary hormone cell types of the female rat. Neuroendocrinology 62:178-186, 1995. 301. Bhat, G.K., Mahesh, V.B., Lamar, C.A., Ping, L. Aguan, K. and Brann, D.W. Histochemical localization of nitric oxide neurons in the hypothalamus: Association with gonadotropin-releasing hormone neurons and co-localization with N-methyl-D-aspartate receptors. Neuroendocrinology 62:187-197, 1995. 302. Hendry, L.B. and Mahesh, V.B. A putative step in steroid hormone action involves insertion of steroid ligands into DNA facilitated by receptor proteins. J. Steroid Biochem. & Molec. Biol., 55:173-183, 1995. 303. Hendry, L.B., Mahesh, V.B., Bransome, Jr., E.D., Hutson, M.S. and Campbell, L.K. A stereochemical rationale for the genetic code derived from complementary fit of amino acids into cavities formed in codon/anticodon sequences in double stranded DNA: Further evidence based upon noncomplementarity of untranslated amino acids. World Wide Webb Journal of Biology, Vol. 1, http://fentonnet.com.epress.wjbio, 1995. 304. Unda, R., Brann, D.W. and Mahesh, V.B. Progesterone suppression of glutamic acid decarboxylase (GAD67) mRNA levels in the preoptic area: Correlation to the luteinizing hormone surge. Neuroendocrinology 62:562-570, 1995. 305. Ramamoorthy, S., Ramamoorthy, J.D., Prasad, P.D., Bhat, G.K., Mahesh, V.B., Leibach, H. and Ganapathy, V. Regulation of the human serotonin transporter by interlukin-1B. Biochem. Biophys. Res. Com. 216:560-567, 1995. 306. Lamar, C.A., Mahesh, V.B. and Brann, D.W. Regulation of gonadotropin-releasing hormone (GnRH) secretion by heme molecules: A regulatory role for carbon monoxide? Endocrinology 137:790-793, 1996. 307. Rapkin, A.J., Shoupe, D., Reading, A., Bohn, Y., Brann, D.W. and Mahesh, V.B. Decreased Central opioid activity in premenstrual syndrome: Luteinizing hormone response to naloxone. J. Soc. Gynecol. Invest. 3:93-98, 1996. 308. Hendry, L.B., Chu, D.K., Mahesh, V.B., Bransome, E.D., Jr., Hutson, M.S. and Campbell, L.K. A stereochemical rationale for the genetic code, and a novel drug design methodology based on modeling the fit of small molecules to sites on DNA. Compumed 1994 Congress Proceedings, 1996. 309. Mahesh, V.B., Brann, D.W. and Hendry L.B. Diverse modes of progesterone and its metabolites. J. Steroid Biochem. & Molec. Biol. 56:209-219, 1996. 310. Zhou, Z., Mahesh, V.B., Zamorano, P.L. and Brann, D.W. Decreased gonadotropinreleasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: A possible role in reproductive aging. Endocrinology 137:2334-2338, 1996. 311. Reilly, C.M., Cannady, W.E., Mahesh, V.B., Stopper, V.S., De Sevilla, L.M. and Mills, T.M. Duration of estrogen exposure prior to follicle-stimulating hormone stimulation is critical to granulosa cell growth and differentiation in rats. Biology of Reproduction 54:1336-1342, 1996. 312. Zamorano, P.L., Mahesh, V.B. and Brann, D.W. Quantitative RT-PCR for neuroendocrine studies -a minireview. Neuroendocrinology (MiniReview), 63:397-407, 1996. 313. Bhat, G., Mahesh, V.B., Aguan, K. and Brann, D.W. Evidence that brain-nitric oxide synthase is the major nitric oxide synthase isoform in the hypothalamus of the adult female rat and that nitric oxide potently regulates hypothalamic cGMP levels. Neuroendocrinology 64:93-102, 1996. 314. Hoffman, W.H., Shin, M.Y., Donohoue, P.A., Helman, S.W., Brown, S.L., Rosculet, G. and Mahesh, V.B. Phenotypic evolution of classic 21-hydroxylase deficiency. Clin. Endocr. 45:103-109, 1996. 315. Trott, E.A., Plouffe, Jr., L., Hansen, K., Hines, R., Brann, D.W. and Mahesh, V.B. Ovulation induction in clomiphene-resistant anovulatory women with normal dehydroepiandrosterone sulfate levels: Beneficial effects of the addition of dexamethasone during the follicular phase. Fertility and Sterility 66:484-486, 1996. 316. Mora, G.R., Prins, G.S. and Mahesh, V.B. Autoregulation of androgen receptor protein and messenger RNA in rat ventral prostate is protein synthesis dependent. J. Steroid. Biochem. & Molec. Biol. 58:539-549, 1996. 317. Aguan, K., Mahesh, V.B., Ping, L., Bhat, G. and Brann, D.W. Evidence for a physiological role for nitric oxide in the regulation of the LH surge: Effect of central administration of antisense oligonucleotides to nitric oxide synthase. Neuroendocrinology 64:449-455, 1996. 318. Mora, G.R. and Mahesh, V.B. Autoregulation of androgen receptor in rat ventral prostate: Involvement of c-fos as a negative regulator. Molec. Cell. Endocr. 124:111120, 1996. 319. Zuo, Z., Mahesh, V.B., Zamorano, P.L. and Brann, D.W. Decreased GnRH neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: A possible role in reproductive aging. Endocrinology 137:2334-2338, 1996 320. Zamorano, P., Mahesh, V.B., De Sevilla, L.M., Chorich, L.P., Bhat, G.K. and Brann, D.W. Expression and localization of the leptin receptor in endocrine and neuroendocrine tissues of the rat. Neuroendocrinology 65:223-228, 1997. 321. Brann, D.W., Bhat, G.K., Lamar, C.A. and Mahesh, V.B. Gaseous transmitters and neuroendocrine regulation. Neuroendocrinology 65:385-395, 1997. 322. Ogle, T.F, Dai, D., George, P. and Mahesh, V.B. Stromal cell progesterone and estrogen receptors during proliferation and regression of the decidua basalis in the pregnant rat. Biol. Reprod. 57:495-506, 1997. 323. Brann, D.W. and Mahesh, V.B. Excitatory amino acids: Evidence for a role in the control of reproduction and anterior pituitary hormone secretion. Endocrine Reviews 18:678-700, 1997. 324. Ping, L., Mahesh, V.B., Bhat, G.K. and Brann, D.W. Regulation of gonadotropinreleasing hormone and luteinizing hormone secretion by AMPA receptors. Neuroendocrinology 66:246-253, 1997. 325.Zamorano, P.L., De Sevilla, L., Mahesh, V.B. and Brann, D.W. Production and refolding of recombinant leptin. BioTechniques . 23, No.5, 1997. 326. Rapkin, A.J., Morgan, M., Goldman, L., Brann, D.W., Simone, D. and Mahesh, V.B. Progesterone metabolite allopregnanolone in women with premenstrual syndrome. Obstetrics and Gynecology 90:709-714, 1997. 327. O'Conner, J.L., Wade, M.F., Prendergast, P., Edwards, D.P., Boonyaratanakornkit, V. and Mahesh, V.B. A 361 base pair region of the rat FSH-b promoter contains multiple progesterone receptor binding sequences and confers progesterone responsiveness. Molec. & Cell. Endocr. 136:67-78, 1997. 328. Hendry, L.B., Bransome, E.D. and Mahesh, V.B. The ligand insertion hypothesis in the genomic action of steroid hormones. J. Steroid. Biochem. & Molec. Biol. 65:75-89, 1998. 329. Bhat, G.K., Mahesh, V.B., Ping, L., Chorich, L., Wiedmeier, V.T. and Brann, D.W. Opioid-glutamate-nitric oxide connection in the regulation of luteinizing hormone secretion in the rat. Endocrinology 139:955-960, 1998. 330. Shi, B., Mahesh, V.B., Bhat, G.K., Ping, L. and Brann, D.W. Evidence for a role of bradykinin neurons in the control of gonadotropin-hormone releasing hormone secretion. Neuroendocrinology 67:209-218, 1998. 331. Mahesh, V.B. and Brann, D.W. Neuroendocrine mechanisms underlying the control of gonadotropin secretion by steroids. Steroids 63:252-256 , 1998. 332. Ogle, T.F., Dai, D., George, P. and Mahesh, V.B. Regulation of the progesterone receptor and estrogen receptor in decidua basalis by progesterone and estradiol during pregnancy. Biol. Reprod. 58:1188-1198, 1998. 333. Buchanan, C.L., Mahesh, V.B., Zamorano, P.L. and Brann, D.W. Central nervous system effects of leptin. Trends Endocrinol. Metab. 9:146-150, 1998 (Invited MiniReview). 334.Zamorano, P.L., Mahesh, V.B., De Sevilla, L. and Brann, D.W. Excitatory amino acid receptors and puberty. Steroids 63:268-270, 1998. 335 .Mahesh, V.B. and Brann, D.W. Regulation of the preovulatory gonadotropin surge by endogenous steroids. Steroids 63:616-629, 1998 (Invited MiniReview). 336. Mahesh, V.B., Zamorano, P., De Sevilla, L., Lewis, D. and Brann, D.W. Characterization of ionotropic glutamate receptors in rat hypothalamus, pituitary and immortalized gonadotropin-releasing hormone (GnRH) neurons (GT1-7 Cells). Neuroendocrinology 69:397-407, 1999. 337. Shi, B., Bhat, G., Mahesh, V.B., Brotto, M., Nosek, T.M. and Brann, D.W. Bradykinin receptor localization and cell signaling pathways used by bradykinin in the regulation of gonadotropin-releasing hormone secretion. Endocrinology 140:4669-4676, 1999. 338 Brann, D.W., De Sevilla, L., Zamorano, P.L. and Mahesh, V.B. Regulation of leptin gene expression and secretion by steroid hormones. Steroids 64:659-663, 1999. 339. Lamar, C.A., Bhat, G.K., Mahesh, V.B. and Brann, D.W. Evidence that neuronal nitric oxide synthase but not heme oxygenase increases in the hypothalamus on proestrus afternoon. Neuroendocrinology 70:360-367, 1999. 340. Brann, DW., De Sevilla, L., Zamorano, PL., and Mahesh, VB. Regulation of leptin gene expression and secretion by steroid hormones. Steroids 64: 659-663,1999. 341. Hendry, L.B., Roach, L.W. and Mahesh, V.B. Multidimensional screening and design of pharmaceuticals by using endocrine pharmacophores. Steroids 64:570-575, 1999. 342. Mora, G.R. and Mahesh, V.B. Autoregulation of the androgen receptor at the translational level: Testosterone induces accumulation of androgen receptor mRNA in the rat ventral prostate polyribosomes. Steroids 64:587-591, 1999. 343. O'Conner, J.L., Wade, M.F., Edwards, D.P. and Mahesh, V.B. Progesterone and regulation of the follicle-stimulating hormone (FSH-beta) gene. Steroids 64:592-597, 1999. 344. Akinbami, M.A., Philip, G.H., Sridaran, R., Mahesh, V.B. and Mann, D.R. Expression of mRNA and proteins for testicular steroidogenic enzymes and brain and pituitary mRNA for glutamate receptors in rats exposed to immobilization stress. J. Steroid. Biochem. & Molec. Biol. 70:143-150, 1999. 345. Cannady, WE., Brann, DW., and Mahesh, VB. The potential role of periovarian fat andleptin the initiation of puberty. Intl. J. Obesity & Related Metabolic Disorders Suppl. 12, S 146-147, 2000. 346. Buchanan,CD., Mahesh, VB., and Brann, DW. Estrogen-astrocyte-luteinizing hormone releasing hormone signaling :A role for transforming growth factor-beta-1. Biol. Reprod. 62: 1710-1721, 2000. 347. Mahesh, VB., Roach, LW., Cannady, WE., Ogle, TF., Brann, DW., Bransome, ED., and Hendry, LB. Gene based pharmacophores for drug design. Med. Chem. Res. 10 : 440455, 2001. 348. Brann, D.W., Greenbaum, L.M., Mahesh, V.B. and Gao, X. Activation of the kinin system in the ovary during ovulation: Role of endogenous progesterone. BMC Physiol. 2:7, 2002. 349. Dhandapani, K.M., Wade, M.F., Mahesh, V.B. and Brann, D.W. Basic fibroblast growth factor induces TGF-beta release in an isoform and glioma-specific manner. Neuroreport. 13:239-41, 2002. 350. Brann, D.W., Wade, M.F., Dhandapani, K.M., Mahesh, V.B. and Buchanan, C.D. Leptin and reproduction. Steroids 67:95-104, 2002. 351. Brann, DW., Unda, R., Mahesh, VB. Role of progesterone receptorin restrained glutamic acid decarboxylase gene expression in the hypothalamus during the preovultory luteinizing hormone surge. Neuroendocrinology 76: 283-289, 2002. 352. Mehta, SH., Dhandapani, KM., De Seville, LM., Webb, RC Mahesh, VB., and Brann, DW. Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat. Neuroendocrinology 77: 44-50, 2003. 353 Dhandapani, KM., Mahesh, VB., and Brann, DW. Astrocytes and brain function: implications for reproduction. Exp. Boil. Med. 228:253-260, 2003. Review 354. Dhandapani, KM., Hadman, M., De Seville, L., Wade, MF. Mahesh, VB., and Brann, DW. Astrocyte protection of neurons: Role of transforming growth factor – beta signaling via c-Jun-AP-1 protective pathway. J. Biol. Chem. 278: 44329-44339, 2003. 355. Mahesh, VB, Ewing DE, Sidell N, Bransome Jr ED and Hendry LB. New Technology for drug discovery based upon insertion of ligands into gene sequences by nuclear receptor proteins. Med. Chem. Res. 13: 497-508, 2004 356. Brann, DW, and Mahesh VB. The aging reproductive neuroendocrine axis. Steroids 70: 273-283, 2005 357 .Dhandapani KM, Wade FM, Mahesh VB, and Brann DW. Astrocyte derived transforming growth factor- β mediates the neuroprotective effects of 17β-estradiol: Involvement of non-classical genomic signaling pathways. Endocrinology 146:27492759, 2005. 358. Brann DW, Zamorano PL, DeSevilla L and Mahesh VB. Expression of glutamate receptor subunits in the hypothalamus of the female rat during the afternoon of the proestrous LH surge and effects of antiprogestin treatment and aging. Neuroendocrinology 81: 120-128, 2005 359. Wade FM, Wakade C, Mahesh VB, and Brann DW. Differential expression of the peripheral benzodiazepine receptor and gremlin during adipogenesis as identified by differential display analysis. Obesity Research 13: 818-822, 2005 360. Dhandapani KM, Wade FM, Mahesh VB and Brann DW. Neuroprotection by stem cell factor in rat cortical neurons involves Akt and NFқB. J. Neurochem. 95: 9-19, 2005 PMID 16181409 361. Khan MM, Hadman M, Wakade C, DeSevilla L, Dhandapani KM, Mahesh VB, Vadlamudi RK and Brann DW. Cloning, expression and localization of MNAR/PELP1 in rodent brain: Colocalization in estrogen receptor-α but not in gonadotropin-releasing hormone-positive neurons. Endocrinology 146:5215-5227, 2005. E Pub Sept. 1 PMID 16143197 362. Mahesh, VB and Brann DW. Regulatory role of excitatory amino acids in reproduction. Endocrine 28: 271-280, 2005 PMID 16388116. 363 Mahesh VB, Dhandapani, KM and Brann DW. Role of astrocytes in reproduction and neuroprotection. Mol.Cell.Endocrinol. 246: 1-9, 2006 E Pub Jan 18,2006 PMID 16388890. 364. Dhandapani KM, Khan MM, Wade FM,Wakade C, Mahesh VB, Brann DW. Induction of transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK/ERK signaling and AP-1 activation. J Neurosci Res. 85: 1033-1045, 2007 E Pub Mar 4; PMID: 17335076 365. Brann DW, Dhandapani K, Wakade C, Mahesh VB, Khan MM. Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications. Steroids. 72: 381-405, 2007; [Epub Feb 21] PMID: 17379265 366. Hendry, LB, Mahesh, VB, Bransome, ED Jr, and Ewing, DE: Small molecule intercalation with double stranded DNA: Implications for normal gene regulation and for predicting the biological efficacy and genotoxicity of drugs and other chemicals, Mutat. Res.: Fundam. Mol. Mech. Mutagen., 623, 53-71, 2007. E-pub. March 24, 2007 doi:10.1016/j.mrfmmm.2007.03.009 367. Dhandapani, KM, Mahesh, VB, Brann, DW: Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. J Neurochem.: 102,522-538, 2007 PMID: 17596214. 368. Wakade, C, Khan, MM, DeSevilla LM, Zhang, Q-G, Mahesh, VB, and Brann, DW: Cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase. Endocrinology Sept. 27, 2007 as doi:10.1210/en.2007-0899. 369. Wakade C, Khan MM, De Sevilla LM, Zhang QG, Mahesh VB, Brann DW. Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase. Endocrinology.: 149:367-79, 2008. Epub 2007 Sep 27. 370. Mahesh, VB, Ewing, DE, Hendry, LB. Assessing activity and toxicity of drugs in silico based on DNA structure. Medicinal Chemistry Research, 17: 159-168, 2008. DOI 10.1007/S00044-007-9046-3 371. Zhang,Q-G, Wang,R, Khan,M, Mahesh,VB, Brann,DW. Role of Dickkopf-1 (Dkk1), an Antagonist of the Wnt- β-Catenin Signaling Pathway, in Estrogen-Induced Neuroprotection and Attenuation of Tau Phosphorylation. J.Neuroscience; 28: 84308441, 2008 372. Brann DW, Mahesh VB. New insights into estrogen signaling and actions in the brain. Molecular and Cellular Endocrinology, 290:1, 2008 PMID: 18599192 373. Brann DW, Zhang Q-G, Wang RM, Mahesh VB, Vadlamudi RK. PELP1—A novel estrogen receptor-interacting protein in the brain. Molecular & Cellular Endocrinology. 290: 2-7, 2008. PMID: 18599192. 374. Mahesh VB, Neil Sidell N, Ewing DE, BransomeJr ED, Hendry LB A Molecular Guidance System Based Upon Target Genes, NuclearReceptors and Ligands Applied to Drug Discovery and Prediction ofToxicity. Mini-Reviews in Medicinal Chemistry, 8, 1252-1264 , 2008 375. Khan M, De Sevilla L, Mahesh VB, Brann DW Enhanced Glutamatergic and Decreased Gabaergic Synaptic Appositions to GnRH Neurons on Proestrus in the Rat: Modulatory Effect of Aging. PLoS ONE 5, 2009 e10172. doi:10.1371/journal.pone.0010172 376. Dhandapani KM, Khan MM, Wade FM,Wakade C, Mahesh VB, Brann DW. Induction of transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK/ERK signaling and AP-1 activation. J Neurosci Res. 85: 1033-1045, 2007 E Pub Mar 4; PMID: 17335076 377. Brann DW, Dhandapani K, Wakade C, Mahesh VB, Khan MM. Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications. Steroids. 72: 381-405, 2007; [Epub Feb 21] PMID: 17379265 [PubMed - as supplied by publisher] 378. Hendry, LB, Mahesh, VB, Bransome, ED Jr, and Ewing, DE: Small molecule intercalation with double stranded DNA: Implications for normal gene regulation and for predicting the biological efficacy and genotoxicity of drugs and other chemicals, Mutat. Res.:Fundam. Mol. Mech. Mutagen. 623: 53-71, 2007. E-pub. March 24, 2007 doi:10.1016/j.mrfmmm.2007.03.009 379 Dhandapani, KM, Mahesh, VB, Brann, DW: Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. J Neurochem.: 102: 522-538, 2007. PMID: 17596214. 380. Wakade, C, Khan, MM, DeSevilla LM, Zhang, Q-G, Mahesh, VB, and Brann, DW: Cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase. Endocrinology Sept. 27, 2007 as doi:10.1210/en.2007-0899. 381. Wakade C, Khan MM, De Sevilla LM, Zhang QG, Mahesh VB, Brann DW. Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase. Endocrinology. 149:367-79,2008 Epub 2007 Sep 27. 382. Mahesh, VB, Ewing, DE, Hendry, LB. Assessing activity and toxicity of drugs in silico based on DNA structure. Medicinal Chemistry Research,:17: 159168,2008 DOI 10.1007/S00044-007-9046-3 383. Zhang,Q-G, Wang,R, Khan,M, Mahesh,VB, Brann,DW. Role of Dickkopf-1 (Dkk1), an Antagonist of the Wnt- β-Catenin Signaling Pathway, in Estrogen-Induced Neuroprotection and Attenuation of Tau Phosphorylation. J.Neuroscience 28: 84308441,2008 384. Brann DW, Mahesh VB. New insights into estrogen signaling and actions in the brain. Molecular and Cellular Endocrinology, 290:1, 2008. PMID: 18599192 385. Brann DW, Zhang Q-G, Wang RM, Mahesh VB, Vadlamudi RK.(2008)PELP1—A novel estrogen receptor-interacting protein in the brain. Molecular & Cellular Endocrinology. 290: 2-7,2008. PMID: 18599192. 386. Mahesh VB, Neil Sidell N, Ewing DE, BransomeJr ED, Hendry LB AMolecular Guidance System Based Upon Target Genes, NuclearReceptors and Ligands Applied to Drug Discovery and Prediction ofToxicity. Mini-Reviews in Medicinal Chemistry 8: 1252-1264, 2008 387. Khan M, De Sevilla L, Mahesh VB, Brann DW Enhanced Glutamatergic and Decreased Gabaergic Synaptic Appositions to GnRH Neurons on Proestrus in the Rat: Modulatory Effect of Aging. PLoS ONE 5 e10172 2010. doi:10.1371/journal.pone.0010172 388 Mahesh VB. Hirsutism, virilism, polycystic ovarian disease, and the steroidgonadotropin- feedback system: A Career Retrospective. Am. J. Physiol.Endocrinol.Metab. 320:E4-E18, 2102 Commentaries in Faculty of 1000 Luteinizing Hormone Plasmid Therapy Results in Long-Lasting High Circulating Lh and Increased Sperm Production in European Sea Bass (Dicentrarchus labrax). Mazón MJ, Zanuy S, Muñoz I, Carrillo M, Gómez A. Biol Reprod 2013; 88(2):32 PMID: 23255338 DOI: 10.1095/biolreprod.112.102640 Last edited: 01 Mar 2013 View Evaluation Molecular profiling of postnatal development of the hypothalamus in female and male rats. Walker DM, Kirson D, Perez LF, Gore AC. 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Greenblatt, R.B., (ed.), Charles C. Thomas, Publishers. Springfield, IL, pp. 179-194, 1963. 3. Greenblatt, R.B., Dominquez, C.J. and Mahesh, V.B. Achard-Thiers Syndrome. In: The Hirsute Female. Greenblatt, R.B., (ed.), Charles C. Thomas, Publishers, Springfield, IL., pp. 251-268, 1963. 4. Mahesh, V.B. and Greenblatt, R.B. Significance of Excessive Androgen Production by the Polycystic Ovary and Its Relationship to Enzymatic Abnormalities. In: Pituitary-Ovarian Endocrinology. Dorfman, R.I. and Castro, M.N., (eds.), Holden-Day, Inc., San Francisco, CA., pp. 60-73, 1963. 5. . Mahesh, V.B. Paper Chromatography of Estrogens. In: Estrogen Assays in Clinical Medicine. Paulsen, C.A., (ed.), University of Washington Press, Seattle, WA., pp. 30-34, 1964. 6. . Mahesh, V.B. Flourimetric Determination of Urinary Estrogens. In: Estrogen Assays in Clinical Medicine. Paulsen, C.A., (ed.), University of Washington Press, Seattle, Washington, pp. 89-99, 1964. 7. Mahesh, V.B. Effect of Human Pituitary Gonadotropin of the Synthesis of Steroids by the Normal and Polycystic Ovary. In: Estrogen Assays in Clinical Medicine. Paulsen, C.A., University of Washington Press, WA, pp. 221-228, 1964. 8. . Greenblatt, R.B. and Mahesh, V.B. Induction of Ovulation with Clomiphene Citrate. Special Chapter in Year Book of Endocrinology. Schwartz, T.B. (ed.), pp. 248-267, 1964-65. 9. . Mahesh, V.B. Response of the Ovary to Suppressing and Stimulating Agents. In: Ovulation. Greenblatt, R.B., (ed.), J.B. Lippincott Company, pp. 166-177, 1966. 10. . Mahesh, V.B. and Greenblatt, R.B. Hirsutism. In: Adolescent Gynecology. Heald, P., (ed.), William and Wilkins Co., pp. 77-103, 1966. 11. . Mahesh, V.B. and Greenblatt, R.B. Adrenogenital Syndrome. In: Management of Amenorrhea. Collins, C.J., (ed.), Charles C. Thomas, Springfield, IL, pp. 1-39, 1966. 12. 12. Mahesh, V.B., Greenblatt, R.B. and Coniff, R.F. Investigation of the Hirsute or Virilized Female. In: Advances in Obstetrics and Gynecology. Marcus and Marcus, (eds.) William and Wilkins Co., pp. 372-385, 1967. 13. Mahesh, V.B. Testicular Feminization. In: Congenital Anamolies. Rashad, M.N., (ed.), Belfast, Ireland, pp. 599-611, 1967. 14. Greenblatt, R.B., Zarate, A. and Mahesh, V.B. Induction of Ovulation in the Human with Clomiphene Citrate. In: Revista Venezolana de Obstetricia Y Ginecologia. Augero, Oscar, (eds.) Venezuela, pp. 477-483, 1967. 15. Mahesh, V.B. and Greenblatt, R.B. Adrenal and Ovarian Variants of the Stein-Leventhal Syndrome. Transactions of the Third Meeting of the International Study Group for Steroid Hormones. In: Research on Steroids. Vol. III, pp. 249-257, 1967. 16. Mahesh, V.B. and Greenblatt, R.B. Hormonal Studies in Females with Virilizing Adrenal Tumors. Transactions of the Third Meeting of the International Study Group for Steroid Hormones. In: Research on Steroids. Vol. III, pp. 221-231, 1967. 17. Mahesh, V.B. and Greenblatt, R.B. Proceedings of the II Annual Symposium on the Physiology and Pathology of Human Reproduction. In: The Ovary. Inquilla, W. and Greenblatt, R.B. (eds.), Charles C. Thomas, Springfield, IL., pp. 149-165, 1968. 18. Greenblatt, R.B., McDonough, P.G. and Mahesh, V.B. Estrogen Therapy for Inhibition of Linear Growth. Clin. Endocrinol. 2:117-131, 1968. 19. Mahesh, V.B. Evaluation of Androgen Function. In: Progress in Infertility. Behrman & Kistner, (eds.), Little Brown & Co., pp. 987-997, 1968. 20. Greenblatt, R.B., Zarate, A.T. and Mahesh, V.B. Other Ovulation-Inducing Agents: Clomiphene and Other Regimens. In: Textbook of Gynecologic Endocrinology. Jay J. Gold, M.D., F.A.C.P., (ed.), Hoeber Medical Divison, Harper & Row, New York, N.Y., pp. 406-420, 1968. 21. Mahesh, V.B. Secretion of Androgens by the Ovary. Proceedings of the Florentine Conference. In: The Ovary. Inquilla, W. and Greenblatt, R.B., (eds.), Charles C. Thomas, Springfield, IL, pp. 72-81, 1969. 22. Greenblatt, R.B. and Mahesh, V.B. Hormones. In: Colliers Encylopedia, Corwell-Collier Educational Corporation, pp. 243-250, 1969. 23. Greenblatt, R.B., Mahesh, V.B. and Scholer, H.F.L. Endocrine Functions of the Male and Female Gonads. In: Tice's Practice of Medicine, Harper & Row, Vol. III. Chapter 32, pp. 1-38, 1970. 24. Greenblatt, R.B., Gambrell, R.D., Mahesh, V.B. and Scholer, H.F.L. Clomiphene and Its Isomers. In: Nobel Symposium 15, Control of Human Fertility. Diczfalusy, E. and Borell, U. (eds.), John Wiley and Sons, N.Y., pp. 263-280, 1971. 25. Mahesh, V.B., Greenblatt, R.B., Scholer, H.F.L. and Ellegood, J.O. Steroid and Gonadotropin Secretion in the Polycystic Ovary Syndrome. In: Recent Advances in Endocrinology, Excerpta. Med. Int. Congr. Ser. 238:160-167, 1971. 26. Mahesh, V.B., Muldoon, T.G., Eldridge, J.C. and Korach, K.S. Studies on the Regulation of FSH and LH Secretion by Gonadal Steroids. In: Gonadotropins. Saxena, B., (ed.), John Wiley and Sons, pp. 730-748, 1972. 27. Mahesh, V.B. and Stahl, N.L. Hirsutism and Virilism. In: Clinician V., Monograph Honoring Gregory Pincus. Greenblatt, R.B., (ed.), (Guest Editor-in-Chief), Medcom Press, NY, pp. 66-75, 1972. 28. Greenblatt, R.B., Mahesh, V.B. and Gambrell, R.D., Jr. Arrhenoblastoma: Three Case Reports. In: The Searle Review of Obstetrics and Gynecologic Literature 1973. Science and Medicine Publishing Co., Inc., pp. 567-576, 1973. 29. Mahesh, V.B. Studies on the Role of FSH and LH in the Induction of Ovulation. In: Human Reproduction. DaPaz, A.C., Hasegawa, T., Notake, Y. and Hayashi, M., (eds.), Igaku Shoin Ltd., Tokyo, pp. 9-18, 1974. 30. Greenblatt, R.B. and Mahesh, V.B. Clomiphene and Corpus Luteum Function. In: Human Reproduction. Dapaz, A.C., Hasegawa, T., Notake, Y. and Hayashi, M., (eds.), Igaku Shoin Ltd., Tokyo, pp.18-24, 1974. 31. Mahesh, V.B. Current Concepts and Problems in Understanding the Process of Aging. Monograph entitled "The Menopausal Syndrome." Greenblatt, R.B., Mahesh, V.B. and McDonough, P.G. (eds.), MedCom. Med. Update Ser. MedCom Press, N.Y., pp. 3-5, 1974. 32. Greenblatt, R.B. and Mahesh, V.B. Hirsutism. In: Dr/2, Ria: Reproductive Endocrinology. Odell, W.B. (ed.) (Guest) MedCom, Inc., NY, pp. 30-37, 1974. 33. Control of the Secretion of Gonadotropins by Gonadal Steroids in the Immature State and During Puberty. In: Proceedings of the Fifth Asia and Oceania Congress Endocrinology. Chandigarh, India, pp. 1-12, 1974. 34. Greenblatt, R.B., Zarate, A. and Mahesh, V.B. Other Ovulation Inducing Agents-Clomiphene and Other Regimens. In: Textbook of Gynecologic Endocrinology. Jay J. Gold, (ed.), Harper and Row, Hagerstown, Maryland, pp. 384-398, 1975. 35. Mahesh, V.B. The Interrelationship Between Steroids and Gonadotropin Secretion During the Ovulatory Cycle. In: Recent Advances in Human Reproduction. Excerpta Med. Princeton, pp. 161-173, 1975. 36. Mahesh, V.B. The Inter-Relationship between Steroids and Gonadotropin Secretion During the Ovulatory Cycle. In: Recent Advances in Endometriosis. Robert B. Greenblatt, (ed.), Excerpta Med., Amsterdam, pp. 32-45, 1976. 37. Mahesh, V.B. Gonadotrophins in the Menopause. In: Consensus on Menopause Research. Van Keep, P.A., Greenblatt, R.B. and Albeaux-Fernet, M., (eds.), MTP Press Limited, Lancaster, England, pp. 11-18, 1976. 38. Allen, M.B., Jr., G.H. Greeley, Jr., A. Costoff, V.B. Mahesh and K.Y. Little. Experimental Models for Study of Pituitary Function. In: The Pituitary - A Current Review. Marshall B. Allen and Virendra B. Mahesh (eds.), Academic Press, NY, pp. 235-260, 1977. 39. Mahesh, V.B. and J.C. McPherson, III. Steroid Hormone Feedback System for the Control of Pituitary Function. In: The Pituitary - A Current Review. Marshall B. Allen, Jr. and Virendra B. Mahesh, (eds.), Academic Press, N.Y., pp. 261-294, 1977. 40. Mills, T.M. and Mahesh, V.B. Gonadotropin Secretion in the Menopause. In: Clinics in Obstetrics and Gynecology. Greenblatt, R.B. and Studd, J., (eds.), W.B. Saunders Company Ltd., London, England, pp. 71-84, 1977. 41. Mahesh, V.B., Mills, T.M., Lin, T.J., Ellegood, J.O. and Braselton, W.E. Metabolism, Metabolic Clearance Rate, Blood Metabolites and Blood Half-life of Norethindrone and Mestranol. In: Pharmacology of Steroid Contraceptive Drugs. Garattini, S. and Berendes, H.W. (eds.), Raven Press, N.Y. pp. 117-130, 1977. 42. Mahesh, V.B. Excessive Androgen Secretion and Use of Anti-androgens in Endocrine Therapy. In: Androgens and Anti-Androgens. Martini, L. and Mottee, M. (eds.), Raven Press, NY, pp. 321-326, 1977. 43. Mahesh, V.B., McPherson, J.C. Regulation of Gonadotropin Secretion by Estradiol and Progesterone. In: Endocrinology of the Ovary. Scholler, R., (ed.), Editions SEPE, Paris, France, pp. 109-131, 1978. 44. Mills, T.M. and Mahesh, V.B. Pituitary Function in the Aged. In: Geriatric Endocrinology. Greenblatt, R.B., (ed.), Raven Press, N.Y., pp. 1-12, 1978. 45. Mahesh, V.B. Hormonal Patterns and Interrelationships During the Ovulatory Cycle. In: Induction of Ovulation. Greenblatt, R.B., (ed.), Lea & Febiger, Philadelphia, pp. 129-160, 1979. 46. Mahesh, V.B. and McPherson, J.C. Modulation of Gonadotropin Secretion by Steroids. In: Recent Advance in Reproduction and Regulation of Fertility. Talwar, G.P., (ed.), Elsevier/ North-Holland, pp. 8-18, 1979. 47. Mahesh, V.B. The Polycystic Ovary Syndrome and its Pathogenesis. In: Proc. IX World Congr. Gynecol. Obstet., Nakayama, (eds.), Elsevier/North-Holland publishers. October 25-31, 1979. 48. Mahesh, V.B. The Normal Menstrual Cycle and Ovulation. In: The Infertile Female. James R. Givens, Editor, Year Book Medical Publisher, Inc., pp. 49-72, 1979. 49. Bransome, Edwin D. Jr., Lawrence B. Hendry, Virendra B. Mahesh, C. Robert Baisden. What is the Future of Liquid Scintillation Counting (LSC) in Clinical Chemistry and in Clinical Research. In: LSC Recent Application in Development. Volume 2: Sample Preparation and Application. Peng, C.T., Harrocks, T. and Elpen, E.L., (eds.), Academic Press, NY, pp. 525-534, 1980. 50. Mahesh, V.B. Current Concepts of the Pathophysiology of the Polycystic Ovary Syndrome. In: Endocrine Physiopathology of the Ovary. R.I. Tozzini, G. Reeves and R.L. Pineda, (eds.), Elsevier/North-Holland Biomedical Press, pp. 275-295, 1980. 51. Natrajan, P., Greenblatt, R.B., Mahesh, V.B. Induction of Ovulation with Clomiphene Citrate. In: Endocrine Physiopathology of the Ovary. R.I. Tozzini, G. Reeves and R.L. Pineda, (eds.), Elsevier/North-Holland Biomedical Press, pp. 365-373, 1980. 52. Mahesh, V.B., Greenblatt, R.B., Zarate, A. Other Ovulation-Induction Agents: Clomiphene and other Regimens. In: Gynecologic Endocrinology, 3rd Edition. Jay J. Gold and John B. Josimovich, (eds.), Harper and Row Publishers, pp. 459-474, 1980. 53. Mahesh, V.B., O'Conner, J.L. and Allen, M.B. In Vivo Model for the Study of Pituitary- Gonadal Relationships. In: Functional Correlates of Hormone in Reproduction. Mahesh, V.B., Muldoon, T.G., Saxena, B.B. and Sadler, W.A. (eds.), Elsevier/North-Holland; NY, pp. 45-61, 1981. 54. O'Conner, J.L., Wolfe, R.R. and Mahesh, V.B. Direct Pituitary Effects of Neonatal Androgenization on the LHRH Response of Dispersed Pituitary Cell Cultures. In: Functional Correlates of Hormone Receptors in Reproduction. Mahesh, V.B., Muldoon, T.G., Saxens B.B. and Sadler, W.A. (eds.), Elsevier/North-Holland, NY, pp. 503-505, 1981. 55. Hendry, L.B., Bransome, E.D., Muldoon, T.G., Mahesh, V.B., Campbell, L.K., and Hutson, M.S. Unique Stereochemical Complimentarity Between Estrogens and DNA. In: Functional Correlates of Hormone in Reproduction. Mahesh, V.B., Muldoon, T.G., Saxena, B.B. and Salder, W.A., (eds.), Elsevier/North-Holland, N.Y., pp. 565-571, 1981. 56. Mahesh, V.B. Luteinizing Hormone Releasing Hormone and its Applications. In: Medizinische Klinik. 76:468-470, 1981. 57. Mahesh, V.B., Muldoon, T.G., Smanik, E.J. and Young, H.K. Interaction Between the Ovaries and the Hypothalamic Pituitary Axis in the Regulation of Gonadotropin Secretion. In: Recent Advances in Fertility Research, Part A: Developments in Reproductive Endocrinology. Muldoon, T.G., Mahesh, V.B. and Perez-Ballester, B. (eds.), Alan R. Liss, Inc., NY, pp. 165-192, 1982. 58. Mahesh, V.B., Costoff, A., Mills, T.M., Bagnell, C.A. The Polycystic Ovary Syndrome and Experimental Models for the Study of its Pathogenesis. In: Recent Advances in Fertility Research, Part A: Developments In Reproductive Endocrinology. Muldoon, T.G., Mahesh, V.B. and Perez-Ballester, B. (eds.), Alan R. Liss, Inc., NY, pp. 301-313, 1982. 59. Mahesh, V.B. Various Concepts of Pathogenesis of Polycystic Ovarian Disease. In: Hirsutism and Virilism. Mahesh, V.B., and Greenblatt, R.B. (eds.), John Wright, PSG, Inc., Boston, MA, pp. 247-276, 1983. 60. Greenblatt, R.B. and Mahesh, V.B. The Androgenic Polycystic Ovary. In: Hirsutism and Virilism, Mahesh, V.B., and R.B. Greenblatt (eds.), John Wright, PSG, Inc., Boston, MA, pp. 213-237, 1983. 61. Mahesh, V.B. Hormone Secretion and Steroidogenesis in the Polycystic Ovary Syndrome. In: Steroid Converting Enzymes and Diseases. Pal, S.B. and Fotherby, K. (eds.), Walter de Gruyter, Berlin, 1984. 62. Mahesh, V.B. Nature and Mechanism of Steroid Modulation of Gonadotropin Secretion. In: Hormone Receptors in Growth and Reproduction. Saxena, B.B., Catt, K.J., Birnbaumer, L. and Martini, L., (eds.), Serono Symposia Publications, Raven Press, NY, Vol. 9, pp. 201-225, 1984. 63. Mahesh, V.B., Murphy, L.L. and Peduto, J.C. Modulation of FSH and LH Secretion by Progesterone and its Metabolites. In: Sterols, Steroids and Bone Metabolism. Martini, L., Gordan, G.S. and Sciarra, F. (eds.), Elsevier Science Publishers B.V., Amsterdam, pp. 71-78, 1984. 64. Mahesh, V.B. Forward. In: Unwanted Hair - Its Cause and Treatment. Greenblatt, R.B., Mahesh, V.B. and Gambrell, R.D. (eds.), The Parthenon Press, Carnforth, Lancs, United Kingdom, pp. 11-13, 1985. 65. Greenblatt, R.B. and Mahesh, V.B. beta -hCG in Breast Cyst Fluid. In: Endocrinology of the Breast and Clinical Aspects. Angeli, A., Bradlow, H.L. and Dogliotti, L. (eds.), New York Academy of Sciences: New York, pp. 632-633, 1986. 66. Hendry, L.B., Muldoon, T.G., Bransome, Jr., E.D., Lehner, A.F., Hutson, M.S., Uberoi, N.K., Myers, R.B., Segaloff, A. and Mahesh, V.B. Predicting Hormonal Activity From the Stereochemistry of Nucleic Acids: A Prospective Study with Novel Estrogenic Steroids. In: Advances in Gene Technology: Molecular Biology of the Endocrine System. Puett, D., Ahmad, F., Black, S., Lopez, D.M., Melner, M.H., Scott, W.A. and Whelan, W.J. (eds.), Cambridge University Press, New York, pp. 292-293, 1986. 67. Lehner, A.F., Muldoon, T.G., Mahesh, V.B., Bransome, Jr., E.D. and Hendry, L.B. The Phytoestrogen Coumestrol Appears Capable of Insertion Between Base Pairs in Agreement with a Stereochemical Rationale for Hormone Action. In: Advances in Gene Technology: Molecular Biology of the Endocrine System. Puett, D., Ahmad, F., Black, S., Lopez, D.M., Melner, M.H., Scott, W.A. and Whelan, W.J. (eds.), Cambridge University Press, New York, pp. 303-304, 1986. 68. Muldoon, T.G. and Mahesh, V.B. Receptor-Weighted Mechanistic Approach to Analysis of the Actions of Estrogen & Progesterone on Gonadotropin Secretion. In: Regulation of Ovarian and Testicular Function. Mahesh, V.B., Dhindsa, D.S., Anderson, E. & Kalra, S.P. (eds.), Plenum Publishing Corp., New York, pp. 47-64, 1987. 69. Mahesh, V.B., Murphy, L.L. and O'Conner, J.L. Selective Modulation of FSH and LH Secretion by Steroids. In: Regulation of Ovarian and Testicular Function. Mahesh, V.B., Dhindsa, D.S., Anderson, E. & Kalra, S.P. (eds.), Plenum Publishing Corp., New York, pp. 131-152, 1987. 70. Mahesh, V.B., Mills, T.M., Bagnell, C.A. and Conway, B.A. Animal Models for Study of Polycystic Ovaries and Ovarian Atresia. In: Regulation of Ovarian and Testicular Function. Mahesh, V.B., Dhindsa, D.S., Anderson, E. & Kalra, S.P. (eds.), Plenum Publishing Corp., New York, pp. 237-257, 1987. 71. Hendry, L.B., Muldoon, T.G. and Mahesh, V.B. Stereochemical Complementarity of Anti-estrogens and DNA. In: Regulation of Ovarian and Testicular Function. Mahesh, V.B., Dhindsa, D.S., Anderson, E., & Kalra, S.P. (eds.), Plenum Publishing Corp., New York, pp. 743-747, 1987. 72. Brann, D.W., Putnam, C.D. and Mahesh, V.B. Regulation of Follicle-Stimulating Hormone secretion by natural and synthetic corticosteroids. In: Regulation and Action of Follicle Stimulating Hormone, Hunzicher-Dunn, M. and Schwartz, N.B. (eds.) Springer-Verlag, New York, pp. 303-309, 1991. 73. Mahesh, V.B. Integration of the effects of ovarian and adrenal steroids in the regulation of gonadotropin secretion in the mammalian ovulatory cycle. In: Clinical Physiology, Thombre, D.P. (ed.), All India Press, Kennedy Nagar, Pondicherry, India, pp. 7-20, 1991. 74. Mahesh, V.B. Studies on the pathogenesis of the polycystic ovary. In: Clinical Physiology, Thombre, D.P. (ed.), All India Press, Kennedy Nagar, Pondicherry, India, pp. 65-80, 1991. 75. Mahesh, V.B., Brann, D.W., Putnam, C.D. Modulation of GABAergic neurotransmission by progestins. In: Biological Psychiatry, Racagni, N., Brucello, N. and Fukuda, T. (eds) Excerpta Medical International Congress Series 968, Volume 2, pp. 518-521, 1991. 76. Hendry, L.B., Chu, C.K., Huang, H., Wood, J.C., Copland, J.A. and Mahesh, V.B. Structure-Activity Relationships, Molecular Modelling and Antitumor Activity of Phenylacetylamino-2,6-Piperidinediones. In: Recent Advances in Chemotherapy, Adam, D., Buchner, T. and Rubenstein, E. (eds.) Futuramed Publishers, Munich, Germany, pp. 2498-2499, 1991. 77. Rao, I.M., Hornsby, P.J. and Mahesh, V.B. Induction of steroidogenesis in a retrovirus transformed rat granulosa cell line. In: Molecular Basis of Reproductive Endocrinology, Leung, P.C.K., Hsuch, A.J.W. & Friesen, H.G. (eds.), Springer-Verlag, New York, pp. 222-229, 1993. 78. Brann, D.W., Mills, T.M. and Mahesh, V.B. Female Reproduction: The Ovulatory Cycle. In: Reproductive Toxicology, Witorsch, R.J. (ed.), Raven Press, New York, pp. 23-44, 1995. 79. Hendry, L.B., Chi, C.K., Mahesh, V.B. Bransome, E.D., Hutson, M.S. and Campbell, L.K. A Steroidochemical Rationale for the Genetic Code and a Novel Drug Design Methodology Based on Modeling of the Fit of Small Molecules to Sites on DNA. World Scientific Press, Chicago, 1996. 80. Brann, D.W. and Mahesh, V.B. Role of Excitatory Amino Acids in Reproduction. In: Excitatory Amino Acids: Their Role in Neuroendocrine Function, Brann, D.W. and Mahesh, V.B. (eds.), CRC Press, Florida, pp. 133-166, 1996. 81. Hendry, L.B., Chu, D.K., Mahesh, V.B., Bransome, E.D., Hutson, M.S. and Campbell, L.K. A Stereochemical Rationale for the Genetic Code and a Novel Drug Design Methodology Based on Modeling of the Fit of Small Molecules to Sites on DNA. In: Proceedings of the 1st World Congress on Computational Medicine, Public Health and Biotechnology, World Scientific Press, Chicago, 1996. 82. Mahesh, V.B. and Brann, D.W. Steroid Control of Hypothalamic Function. In: CNS Neurotransmitters and Neuromodulators: Neuroactive Steroids, Stone, T.W. (ed.), CRC Press, Florida, pp. 177-209, 1997. 83. Mahesh, V.B. Animal Models for the Study of the Polycystic Ovary Syndrome. In: Androgen Excess Disorders in Women, Azziz, R., Nestler, J.E. and Dewailly, D. (eds.), Lippincott-Raven Publishers, Pennsylvania, 1997. BOOKS EDITED 1. The Menopausal Syndrome, Greenblatt, R.B., Mahesh, V.B. and McDonough, P.G., editors. Med. Com. Press, N. Y., 1974. 2. The Pituitary - A Current Review, Allen, Marshall B. and Mahesh, V.B., editors. Academic Press, N. Y., 1977. 3. Functional Correlates of Hormone Receptors in Reproduction, Mahesh, V.B., Muldoon, T.G., Saxena, B.B. and Salder, W.A., editors. Elsevier/North-Holland, N. Y., 1981. 4. Recent Advances in Fertility Research, Part A & B, Muldoon, T.G., Mahesh, V.B. and Perez- Ballester, B., editors. Alan R. Liss, Inc., N. Y., 1982. 5. Hirsutism and Virilism, Mahesh, V.B. and Greenblatt, R.B., editors. John Wright, PSG, Inc., Boston, MA, 1983. 6. Unwanted Hair - Its Cause and Treatment, Greenblatt, R.B., Mahesh, V.B., and Gambrell, R.D., editors. The Parthenon Press, Carnforth, Lancs, United Kingdom, 1985. 7. Regulation of Ovarian and Testicular Function, Mahesh, V.B., Dhindsa, D.H., Anderson, E. and Kalra, S.P., editors. Plenum Press, New York, 1987. 8. Excitatory Amino Acids: Their Role in Neuroendocrine Function, Brann, D.W. and Mahesh, V.B. CRC Press, Boca Raton, Florida, 1996.