Year in Review
Division of Neonatology
2010-2011
University of California San Francisco
Fetal Surgery Works! This year, Dr. Diana Farmer (Pediatric Surgery), Nalin Gupta (Neurosurgery) and the UCSF Fetal Treatment Center reported results of the first randomized,
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controlled multi-center surgical study to show efficacy of fetal closure for spina bifida. UCSF
neonatologists, social workers and nurses all played a role in this important study.
UCSF Division of Neonatology
Annual Review News Letter
2010-2011
William H. Tooley -- Bruce O. Berg dinner 2011at the Cliff House
Dear Faculty, Fellows, Co-workers, Alumni and other Friends,
In the annual letter, I will cover developments and achievements during the
past academic year and our prospects and plans for progress in the coming year. One
of the notable events was the promotion of former Chief of Pediatric Neurology,
Donna Ferriero, MD, to become Chair of Pediatrics at UCSF School of Medicine
and Physician-in-Chief of the USCF Benioff Children’s Hospital. The photo above
is from the 2011 Tooley-Berg dinner in honor of Dr. Joseph J. Volpe, Bronson
Crothers Distinguished Professor of Neurology at Harvard Medical School (pictured
front row center). Dr. Volpe was jointly hosted this year by the Department of Neurology as the 12th annual Bruce O. Berg Visiting Professor, and so we shared a great
evening with colleagues from Pediatric Neurology.
For Alumni, we are pleased to extend “Dinning Rights” and an open invitation to all former trainees and faculty of the Program to join us for the Tooley dinner
as the Division’s guest. It’s one way we can try to stay in touch. We will send an announcement prior to the event with contact information.
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I. Times of Economic Challenge and new ‘Developments’
The University of California continues under economic strain of a weak State
budget, and this affects the UCSF Department of Pediatrics and the Division. All
divisions were asked to make cuts in their annual operating budget. I am happy to
report that the Division of Neonatology has exceeded its target for budget reduction
set by the Department of Pediatrics, due to increased grant support in the form of Kawards and faculty that have retired or will be moving on to new exciting positions t
other academic institutions (See “Special K” below). The Division continues in
sound financial position looking forward into the 2011-12 academic year.
Former UCSF ICN patient who underwent
hypothermia therapy for hypoxic-ischemic encephalopathy in the Neurointensive Care Nursery (NICN), an innovative clinical care collaborative (detailed below).
Fundraising is important for programmatic expansion and support of faculty
research, especially new junior faculty that are making the transition to independence. The Director of Development in Pediatrics, Maureen Royer, is working to
raise such funds for the Division. Interest of alumni and friends of the Division in
this regard would be greatly appreciated. Please consider making a gift! Details can be
found in the “How to Help” section of the website:
http://neonatology.ucsf.edu/about/how-to-help.aspx. Or, you can contact Maureen
Royer directly (415.476.3628, mroyer@support.ucsf.edu).
II. Faculty News
New Faculty
We are thrilled to welcome several new faculty to the Division.
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Timothy Sanders, MD, PhD, is a recent graduate of the UCSF fellowship program
who we have retained as junior faculty. In addition to clinical coverage at UCSF
Moffitt-Parnassus ICN, Tim will continue his research (with supervisor Maria Barna
of the CVRI) on mechanisms used by the Sonic hedgehog signaling to pattern the
developing limb bud.
Olivier Danhaive, MD. Former UCSF visiting professor and attending physician at
Bambino Gesú Hospital in Rome, Italy, Dr. Danhaive, will be joining the permanent
faculty commencing in the 2011-12 academic year as the new Director of the SFGH
nursery. Dr. Danhaive completed his neonatology fellowship training at Boston
Children’s Hospital and has research interests in pulmonary biology.
Transitions:
Magda Petryniak, MD. Magda (pictured with
husband, Greg Potter) completed her fellowship at UCSF and was a sucessful junior
faculty member who’s research focuses on the fundamental biology of
oligodendrocytes in the developing brain and their role in myelination. Her mentors
were John Rubenstein and David Rowitch. Magda was recipient of a KO8 award and
the Polin Prize, allocated to her by Dr. John Clemments. After a nationwide search,
she is now moving on to take an independent laboratory/physician-scientist position
at Oregon Health Sciences University, Portland Oregon. We wish Magda every
success.
David McCulley, MD. David (pictured with wife,
Jill Wildonger) is a graduate of the UCSF neonatology fellowship who has been a
junior faculty member since 2009. He performed his research in the laboratory of
Brian Black (CVRI) on the cellular origins of the cardiac outflow tract, as well as the
signaling pathways critical for its normal development. He and his wife, Jill, plan to
move this winter to take up joint faculty appointments at the University of Wisconsin in Madison. David and Jill are always welcome to visit us and warm up (except in
summer, of course).
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Robert Piecuch, MD. We said goodbye to Dr. Bob, who ran the High Risk Infant
Follow Up program for over 20 years, and who left for drier pastures as medical director of the ICN at Desert Regional Medical Center in Palm Springs. Through the
Follow Up program and with his dynamic personality, Dr. Bob has uniquely connected with our families and referring communities in his many years at UCSF, and
as we made our final visits to many of our satellite clinics, the pediatricians and families came out to thank and say goodbye to him. Many continue to email him with
their children's updates as they finish high school and go to college. In addition, Bob
has been instrumental in the creation of the statewide CCS High Risk Infant FollowUp Program, with the NeuroIntensive Care Nursery, and in overseeing the incredible
growth and productivity of the clinic over the last 20 years. We know Bob will be
back to visit, but we hope he also knows how much he will be missed!
Susan Sniderman, MD. After 38 years
as a neonatologist at Mt. Zion Hospital and UCSF, Susan Sniderman (pictured with
Alma Martinez and David Rowitch) is retiring from her current position as Chief of
Neonatology at SFGH and attending neonatologist at UCSF. Her main interests
have been in improving the outcome and survival in neonatal lung disease and
in cardiopulmonary physiology in the fetus and newborn. Dr. Sniderman participated in early clinical trials to improve the survival of preterm infants by using antenatal steroids to help mature the surfactant deficient lung and prophylactic administration of exogenous synthetic surfactant in very preterm neonates. She is Chair of
the SFGH Committee on Human Research at UCSF.
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Diana Farmer, MD, FRCS. Dr. Farmer
joined the UCSF faculty in 1998 as professor of surgery, pediatrics and obstetrics,
gynecology and reproductive sciences. She became the Surgeon in Chief of the UCSF
Benioff Children’s Hospital. She is the principal investigator for a number of research projects, most notably the multi-center fetal treatment study of prenatal myelomeningocele closure, which showed efficacy (results, featured on the cover were
published recently in the NEJM). She was admitted as a Fellow of the Royal College
of Surgeons, and was the recent recipient of the UCSF Holly Smith award. Dr. Farmer moves on to become Chair of Surgery at UC Davis. But, we will still say,
“WWDD (What would Diana Do)?” when deciding on best surgical treatment options for our patients.
This section acknowledges junior faculty that have achieved distinguished career development awards (e.g., NIH K-series) within the past five years
(2006-2011):
1. Roberta Keller, MD, NIH K23, “Chronic sildenafil for severe diaphragmatic
hernia.”
2. Emin Maltepe, MD, PhD, NIH KO8, “HIF-dependent epigenetic responses
during hypoxia and differentiation.”
3. Magda Petryniak, MD, NIH KO8, “Genetic Mechanisms of Oligodendrogenesis
and Remyelination.”
4. Mike Kuzniewicz, MD, NIH K23, “Genetic Epidemiology of Respiratory Distress Syndrome.”
5. Ann Zovein, MD, Burroughs Wellcome Fund Career Award for Medical Scientists,
“Hematopoietic stem cell emergence from the vasculature.”
6. Trevor Burt, MD, NIH KO8, “Defining the transition from fetal to adult T cell
predominance in the human fetus and neonate.”
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7. Fernando Gonzalez, MD, NIH KO8, ““Erythropoietin and Neurogenesis after
Neonatal Stroke.”
8. Henry Lee, MD, NIH K23, “Maternal, Clinician & Hospital Factors in Breast
milk for Premature Infants.”
A.
Graduating Fellows
Loc Le, MD, MPH. Dr. Le (pictured at
right, with first-year fellows (l-to-r) Lisa Bain and Andrea Wickremasinghe, and Lisa’s husband, Alex) performed his research in Indo-China supported by a UC Pacific
Rim grant where his project and work of collaborators helped to make phototherapy
more accessible in Vietnam. Dr. Le has accepted a faculty position at Cedars-Sinai
Hospital in L.A. where he plans to expand his important policy work applied to developing countries
Timothy Sanders, MD, PhD. Dr. Sanders graduated from the Fellowship and will
be staying as faculty based at Moffitt-Long Hospital (see “New Faculty”, above).
B.
New Fellows. We are happy to welcome two new fellows to the program:
Eunice Rhee, MD. Eunice will be joining our fellowship after completing her Pediatric Residency Program at New York Presbyterian Hospital/Weill Cornell in
New York. She received her undergraduate degree in Brain and Cognitive Sciences from
MIT in 2002. Prior to medical school, Eunice spent a year at Memorial Sloan Kettering
Cancer Center in the lab of Dr. Abu-Rustum (gynecologic oncology). She attended medical
school at UMDNJ/Robert Wood Johnson School of Medicine but spent a year in the middle as a
Clinical Research Training Program Fellow at NIH with Dr. Crystal Mackall exploring the
therapeutic use of monoclonal antibodies of TRAIL (TNF-related apoptosis inducing ligand)
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for pediatric solid tumors. She has continued research during residency studying the immunomodulation of omega-3 fatty acids on the inflammatory process in neonates. She enjoys
international travel, volleyball, bowling, cooking and singing and is looking forward to moving to the Bay Area. Eunice is exploring lab-based research options in immunology and developmental biology.
Luke Judge, MD, PhD. Many may already know Luke who was a pediatric resident here at UCSF. He attended Pomona College where he studied Chemistry before entering the MD/PhD program at the University of Washington, where he received his
degree in Molecular and Cellular Biology. Luke worked in the lab of Dr. Jeffrey Chamberlain where he did functional studies of dystrophin protein isoforms using transgenic mouse
models and recombinant viral vectors. He was accepted into the Molecular Medicine Program at UCSF and we are delighted he has chosen to pursue his fellowship training in Neonatology. Luke has a two lovely kids ages 8yrs and 4yrs old. Luke will be pursuing research
with mentorship from Bruce Conklin who uses induce pluripotent stem cells to study cardiac
disease. For his research, Luke has already obtained a California Institute for Regenerative
Medicine (CIRM) Scholar Award.
C.
Other Fellowship and Training News. Our fellowship selection for
three slots through the match in 2011 is ongoing. Our fellowship slots are highly
competitive with a current acceptance rate of about 1/25 applicants. We anticipate
another exceptional match this year. Notable events in the Fellowship Training Program this year include:
1)
This was a big administrative year for the UCSF Neonatal-Perinatal Medicine Fellowship Program. We had our much anticipated ACGME site visit for accreditation by the Residency Review Committee (RRC). The results are in and we
are proud to report the Fellowship Program was officially accredited by the RRC
for the maximum 5-year cycle before the next mandatory review. We say a BIG
thank you and good luck to our previous Program Coordinator, Sharlene Thompson, MPA, who helped us through the site visit and has since accepted a promotion
to become Program Coordinator for the training programs in the Department of
Anesthesia. We welcome our new Program Coordinator, Kate Shimshock, MSW,
who will also help coordinate the Pediatric Cardiology and Medical Genetics Programs.
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2)
The Annual Fellows Retreat occurred in June and was an opportunity to enjoy some well-deserved time together outside the hospital setting, as well as providing important feedback that was incorporated into the Annual Program review.
3)
The NICHD T32-funded Training Program was reconfigured to provide
enhanced opportunities for Fellows wishing to pursue clinical-translational research. We also have expanded our Program to incorporate areas of new strength at
UCSF including neuroscience and stem cell biology research.
4)
Dr. Gavin Henderson was awarded support through the Pediatric Department’s Institutional T32Grant for 2011-2012. He will continue his research into
the role of placental glycoprotein’sin the establishment of chorioamnionitis with
his research mentor, Dr. Susan Fisher (Stem Cell Program, OB/MFM).
5)
First-year fellow Dr. Luke Judge has already obtained a California Institute
for Regenerative Medicine (CIRM) Scholar Award. He will be pursuing research
with mentorship from Bruce Conklin, MD (Gladstone Institute at UCSF), who
uses induce pluripotent stem cells to study cardiac disease. For his research,
IV. Division Programs: Progress Report
The leadership has generated an inclusive plan for organization of major clinical and research efforts within the Division to provide pathways of career development, falling into two broad categories: 1) clinical services and 2) clinicaltranslational and basic science research.
1)
Clinical Service News
A.
William H. Tooley ICN at Moffitt-Long Hospital The patient census in the 2010-2011 year stabilized compared to the previous year,
but the Division of Neonatology and Department of Pediatrics had an overall financial loss
due to regulatory billing issues. Because the payment environment is uncertain, continuing
efforts to provide the best possible Outreach and service to our referring institutions and
physicians remains crucial. Neonatology remains committed to exploring strategic alliances
with other medical institutions and forging new Outreach affiliations, and some of these alUCSF Division of Neonatology•www.neonatology.ucsf.edu
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liances may come to fruition in the coming year.
Clinical director Yao Sun, MD, with pediatric neurologists
Kendall Nash, MD (left) and Emily Tam, MD (right). 2011 Tooley-Berg dinner.
Changes in the coming year: 1) Because of new residency hour constraints, 1st year
Pediatric Residents will no longer stay overnight for 24 hour in-house call. The effective reduction in residency hours has been offset by the Medical Center with funds to hire new
Neonatal Nurse Practitioners to maintain the staffing of the daytime teams. 2) Implementation of Apex, the new electronic medical record, on the inpatient services is anticipated to
occur in late Spring of 2012.
o Quality Improvement: Continuing QI projects in the ICN include: (1) Reduction
in blood stream infections, (2) Reduction in pressure ulcers, (3) Major disaster planning, and (4) improvement in hand hygiene. In addition, the ICN is participating in
a new California Perinatal Quality Care Collaborative (CPQCC) project to improve
the delivery room resuscitation of low birth weight infants.
o Family-centered care: The PareNT (Parent Nursing Team) Initiative has been
funded by the Medical Center and the School of Nursing to perform its first controlled trial of teaching parents how to provide comfort measures during painful procedures. The Comforting by Family (ComFy) study will start during this coming
academic year. o The Neuro-intensive Care Nursery: The UCSF Neuro-intensive Care Nursery
(NICN) reached a milestone with over150 referrals for therapeutic hypothermia
since opening in July 2008. The aim of this service is to develop a co-management
model with neurology and a strong nursing component to optimize delivery of neuro-protective therapies as well as serve as a research platform for future clinical trials
of new approaches that could optimize care for infants at risk for neurological injury.
Drs. Tom Shimotake, Sonia Bonifacio, Sally Sehring, Roberta Keller, Fernando
Gonzalez, Yao Sun, Emily Tam and Hannah Glass who have taken major roles in
implementing NICN protocols. Sue Peloquin has led the nursing effort and is
building a superb team of NICN nurses (There are currently 26 NICN nurses, and
19 ECMO/NICN nurses, who are becoming expert in neuromonitoring protocols.
This represents 1/3 of our nursing staff), and Deb Dewar has represented the NNPs.
The NICN has been featured in various news stories, see:
http://neonatology.ucsf.edu/news/default.aspx
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NICN Concept. Components of the UCSF NICN comprise: (1, 2) dedicated neonatal neurology and epileptology
services, (3) neonatal neuroimaging, (4) NIDCAP-trained
and neuro-focused ICU nursing staff and long-term neurodevelopmental follow up clinic, (5) delivering already tested
therapies such as hypothermia, and importantly, (6) NIHfunded clinical research studies and integration with basic
scientists of the NBRI to create a translational pipeline and
capability to test novel neuroprotective agents.
The NICN is helping to change
the standard of care for infants at risk for newborn neurological problems. We are
now implementing new and improved protocols for the following broad categories of
patients: (1) Full term HIE/Stroke/Seizures, (2) Pre-term ELBW, (3) Congenital
CNS malformations, (4) Post-op surgical/pain control. In each group, there are
compelling reasons to think that enhanced neuro-monitoring, neuro-imaging and/or
neurological input will improve management. In support of this, new papers published in the past year are showing how NICN care is improving standards (see “Appendix,” below). The NICN concept will be presented at various professional meetings including the National Association of Children’s Hospital and Related Institutions (NACHRI) national meeting this year. Clinical research in the NICN continues to be active (see “Clinical Investigation,” below).
B.
Community & San Francisco General Hospital ICNs
We maintain strong relationships with the community through our ICNs at Santa
Rosa Memorial Hospital, ValleyCare and Natividad. No new community ICN sites have
been added during the past year; however, strategic planning for further development is ongoing and additional collaborations are expected to evolve. Dr. Susan Sniderman has been
recalled from retirement and continues to direct the SFGH nursery service this year but she
will be handing off to Dr. Olivier Danhaive, the new Director of the SFGH ICN.
C.
The High Risk Infant Follow-up Clinic (HRIF)
According to Dr. Liz Rogers, new Director of the HRIF clinic, “Yet again, a year of
change for the ICN Follow-Up Program. The clinic continues to grow. We enrolled 205
infants into the program last year, including 50 patients who were born at 28 gestational
weeks or less and 43 patients admitted with neonatal encephalopathy who underwent therapeutic hypothermia. We enrolled 75 patients referred from the Fetal Treatment Center, clinical research protocols (e.g., PreMRI study) or CDH clinic. In addition, we have referred
many patients to other High Risk Infant Follow Up Programs through CCS. We now have
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data for over 5200 infants in our Follow Up database. We have graduated many 8 and 9
year olds this year, and it is with great pride on our part and theirs that they receive their
graduation certificates, and then often visit the ICN to see the place they were born and
spent their first months.”
Dr. Liz Rogers (right), Follow-Up Clinic Director, with
neonatologist Dr. Sonia Bonifacio, NICN co-Director. 2011 Tooley-Berg dinner.
“We continue to assess for cerebral palsy and cognitive delays, but also screen for social-behavioral disorders such as autism spectrum disorders, sensory processing problems, and
attention deficit and hyperactivity. We have presented our data at the AAP and PAS meetings in the past year and hope to expand our research into these areas. We continue to welcome collaborative research with many groups seeking to study our population, and currently have a medical student on the Health and Societies Pathway who has CHR approval to do
a study on barriers to compliance with the Follow Up Program in order to better understand
our attrition rates and work to improve them. We have improved space for our visits on the
4th floor of ACC. Come visit us in clinic anytime - the parents love seeing familiar faces!”
D.
Future of the Clinical Service at Mission Bay
Our reputation for excellence will no doubt be further
augmented by the move to the new UCSF Benioff Children’s Hospital located at Mission
Bay. We have broken ground at the new site and move in is anticipated in 2015! Check the
web cam at http://missionbayhospitals.ucsf.edu/multimedia/live-webcam. Plans for the new
hospital include a vigorous development effort for new programs. We are grateful to the Benioff family for their inspirational gift and ongoing support. Building the new UCSF Children’s Hospital is a milestone in the Department of Pediatrics at UCSF. Under our new Chair
of Pediatrics, Donna Ferriero, we will build an extra-ordinary clinical-translational enterprise that will lead advances in clinical care and research.
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2)
Summary of Division Research
http://neonatology.ucsf.edu/research/default.aspx
Research in the Division falls into two broad categories: (A) Clinical Investigation,
Epidemiology, Informatics & Health Science Policy, (B) Basic/Lab-based Investigation. The
following sections outline current activities and plans to expand these programs.
A) Clinical Investigation
Given the extensive research activity in the ICN, we have expanded the process for
initiating research studies in the ICN when broader input is needed, through creation of the
Neonatal Clinical Research Committee, coordinated by Drs. Roberta Keller and Ron
Clyman. We have seen an exceptional number of NEW clinical research grants and protocols including:
o TOLSURF (Multicenter PI-R Ballard), investigates late surfactant administration + inhaled NO in patients at risk for BPD. Enrollment has been brisk,
soon to include 20 participating US Hospitals. This is an NIH funded study.
o PROP (Co-PIs-P Ballard/ R Keller), a biomarker study for BPD, part of a
multicenter consortium. Enrollment will start this summer. This is an NIH
funded study.
o NEAT (PI-Y Wu), testing safety of ErythroPOeitin + hypothermia in HIE.
This is a Thrasher Foundation- funded study.
o Indomethacin/feeding study (PI-Clyman), testing tolerance of feeds during
indomethAcin therapy.
o PDA ligation/hypotension study (PI-R Clyman),
o ProPheno seizure study (PI-H Glass), evaluating anti-convulsant needs in patients with uncomplicated neonatal seizures.
o Omega 3-FA and brain injury study (PI-E Tam), investigating regulation of
nutrition in brain injury.
o NEC biomarkers study (PIs-Cooper/Sun), a biomarker study for NEC.
o PreMRI (PI-AJ Barkovich), renewal of this protocol to identify trajectory of
brain development by MR imaging in pre-term infants. This is an NIH
funded study.
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Research Infrastructure. The UCSF CTSA Pediatric Clinical Research Center
(PCRC) nurses and PCRC medical director continue to work with investigators in developing their protocols to optimally recruit and enroll our potential research patient population.
The PCRC currently supports more than 30 research studies and continues to provide educational and procedural support to the NICN staff (e.g., critical care transport education).
There will be new challenges in the future as we try to continue this level of investigator support at a time when an increasing amount of the PCRC costs will be shifted back onto the
investigators. In addition to externally-funded studies, the PCRC is supporting a number of
investigator-initiated studies within the ICN that are currently starting enrollment.
The Clinical Trials Core of the Fetal Treatment Center has been instrumental in
supporting complex clinical trials, such as the MOMS trial (outcomes in pre- vs. postnatal
repair of myelomeningocele, PI-D Farmer,) and the PMD clinical trial (PI-D Rowitch), an
industry sponsored trial testing safety of neural stem cell transplant in patients with the rare
congenital leukodystrophy, Pelizaeus-Merzbacher Disease.
Future Directions. Dr. Roberta Keller will supervise: (1) Development of a Clinical Research section for the Neonatology website, which will include links to affiliated programs, resources and services. (2) An introductory clinical research pamphlet and encounter
for families with a baby newly admitted to the ICN. We hope to that these educational resources will optimize participation in research protocols and avoid overwhelming families
during a stressful period.
B)
Basic/Lab-Based Investigation
Dr. Rowitch leads development of lab-based investigation in the Division. We plan
development of integrated programs for translational research, which incorporate both basic
science and clinical research components. This idea is demonstrated by the historical links of
the CVRI to the ICN.
The Newborn Brain Research Institute (NBRI) was also conceived as a translational
research project linked to the NICN. New basic NBRI research is showing how key developmental regulatory pathways (Sonic hedgehog and Wnt) are involved in human newborn
neurological injuries. Pre-clinical studies of Dr. Fernando Gonzales and Donna Ferriero
have lead to a clinical study of EPO with hypothermia (PI- Yvonne Wu), providing an example of how the NBRI serves to promote new treatments. Efforts of the NBRI have been
featured in the press: http://neonatology.ucsf.edu/news/default.aspx).
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We have brought on line a new support core facility, The Pediatric Research Neuropathology Laboratory< http://ucpnc.pathology.ucsf.edu/>, to help encourage new lines of
patient-oriented investigation into human neurological disorders. This laboratory facility has
already banked over 100 brain specimens for new research into human newborn neurological
injury, supporting new lines of investigation in human neonatal brain development and injury (Fancy et al., 2011, Nature Neuroscience; Sanai et al., Nature)
Our progress will be measured by traditional metrics such as papers published by the
Division, extramural-funding obtained, honors and awards, and most importantly, new opportunities for fully independent lab-based investigators. The NBRI is currently recruiting
for a new lab-based faculty member.
Division Productivity 2010-present
In the past 18 months the fellows have published 7 papers and reviews and
the faculty has published 116 papers and reviews. See the Appendix below for further details. These numbers indicated that the Division continues to be a leader in
academic productivity amongst our peer institutions in Neonatology in the country.
2011 William H. Tooley Professor – Dr. Joseph J. Volpe
Dr. Joseph J. Volpe, Bronson Crothers Distinguished Professor
of Neurology at Harvard Medical School was the 12th Donald G. Berg Distinguished
Lecturer and 14th William H. Tooley Visiting Professor in 2011. Dr. Volpe, considered the father of neonatal neurology, is an internationally recognized clinician and
investigator of newborn neurological injury. Joe spent an intense few days with neonatologists and pediatric neurologists at UCSF discussing latest treatments for infants
at risk for neurological injuries and he delivered several outstanding lectures. Next
year’s Tooley Lecturer will be announced shortly.
Dr. Clements says a few words on his
85th birthday. 2011 Tooley-Berg dinner.
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Former Chief Pediatric Neurologists Bruce Berg, MD and Donna Ferriero, MD, who became the new Chair of Pediatrics at UCSF in 2011. 2011 Tooley-Berg
dinner.
The 2012 Tooley Lecturer will be Professor Alan H. Jobe, MD, PhD, Director of Perinatal Research at Cincinnati Children’s Hospital, who will be visiting us
in mid-late May. For Alumni, we are pleased to extend “Dinning Rights” and an
open invitation to all former trainees and faculty of the Program to join us for the
Tooley dinner as the Division’s guest. We will send an announcement with further
details and contact information in due course.
Staff Appreciation
The support of our outstanding staff is essential to smooth operations of the
Division and we are very thankful to Zoe Ann Hinson-Pardini, Division Administrator, Mary Ulman (assistant to Dr. Rowitch), Cheryl Fong (assistant to Dr. Sun) and
we are pleased to welcome Kate Shimshock, our new coordinator for the neonatology
fellowship program (led by Dr. Shimotake).
Grants Administrator Buffy Hespelt, Neuroscientist Zena Vexler,
Division Administrator, Zoe Ann
Hinson-Pardini and neonatologist
Colin Partridge.
In Closing
While a somewhat challenging year, given the financial pressure faced by the
Division, we continue to make progress. Extramural grant support has increased substantially this year, and we have begun a fund raising campaign to further enable
program development in this climate. We have made progress in terms of quality
improvement and new models of clinical practice (e.g., the NICN), which may further distinguish the Division as a place of clinical innovation. Clinical research and
basic research are both showing in strong growth mode, and I believe we are providing opportunities for our fellows and junior faculty to develop strong research portfolios. It is bittersweet to see our former trainees move on to other institutions, and I
am glad that we had a part of their training. For current, fellows and faculty, I’d like
to say thanks to all of you for your superb work in the ICN and in your research, and
to our alumni, thanks for your ongoing interest in the Division.
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Humbly submitted,
David H. Rowitch, MD, PhD, Professor of Pediatrics & Neurological Surgery, Chief
of Neonatology, Howard Hughes Medical Institute Investigator, UCSF
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Appendix:
List of all peer-reviewed research papers and reviews published or in press over the past
18 months (2010-present)
FELLOWS
Dzietko, Mark
1. Magnetic Resonance Imaging (MRI) as a Translational Tool for the Study of Neonatal
Stroke. Dzietko M, Wendland M, Derugin N, Ferriero DM, Vexler ZS. J Child Neurol.
2011 Jun 13. [Epub ahead of print]
2. Neurotoxic effects of MDMA (ecstasy) on the developing rodent brain. Dzietko M, Sifringer M, Klaus J, Endesfelder S, Brait D, Hansen HH, Bendix I, Felderhoff-Mueser U.
Dev Neurosci. 2010 Aug;32(3):197-207. Epub 2010 Jul 10.
Rhee, Eunice
1. Eunice H. Rhee, Michael M. Espiritu, Jeffrey M Perlman, and Susanna CunninghamRundles “DHA, an Omega-3 PUFA, Modulates the Inflammatory Response of the
Neonatal Cord Blood Cells against an Inflammatory Stimulus” The Art and Science of
Pediatrics Vol 8. 2010
2. Eunice H. Rhee, Elaine Barfield. “Say Yes to Immunizations” NY Metro Parents. 2010
Nov 19 Issue
Sanders, Timothy
1. Park, A.M., Sanders, T.A., and Maltepe, E. Hypoxia inducible factor and HIF stabilizing
agents in neonatology. Seminar Fetal Neonatal Med 15(4): 196-202, 2010.
Wickremasinghe, Andrea
1. Wickremasinghe AC, Hartman TK, Voigt RG, Katusic SK, Weaver AL, Colby CE, Barbaresi WJ. Evaluation of the ability of neurobiological, neurodevelopmental and socioeconmic variables to predict cognitive outcomes in premature infants. Accepted for publication in Child: care, health and development (accepted on June 5 2011).
2. Wickremasinghe AC, Karon BS, Cook WJ. Accuracy of neonatal transcutaneous bilirubin
measurement in the outpatient setting. Accepted for publication in Clinical Pediatrics
(accepted on June 21, 2011).
FACULTY
Ballard, Phillip
1. Merrill JD, Ballard PL, Courtney SE, Durand DJ, Hamvas A, Hibbs AM, Lu KW, Ryan
RM, Reynolds AM, Spence K, Steinhorn RH, Truog WE, Eichenwald EC, Ballard RA.
Pilot trial of late booster doses of surfactant for ventilated premature infants. J Perinatol.
2011 Feb 10. [Epub ahead of print]
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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2. Gonzalez RF, Allen L, Gonzales L, Ballard PL, Dobbs LG. HTII-280, a biomarker specific to the apical plasma membrane of human lung alveolar type II cells. J Histochem
Cytochem. 2010 Oct;58(10):891-901. Epub 2010 Jun 21.
3. Golombek SG, Truog WE, Ballard RA, Ballard PL. Re: 'The use of iNO in the newborn
period: results from the European iNO registry'. Acta Paediatr. 2010 Sep;99(9):1283.
doi: 10.1111/j.1651-2227.2010.01847.x. No abstract available.
4. Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales
LW, Kolla V, Matthay MA. Regulated gene expression in cultured type II cells of adult
human lung. Am J Physiol Lung Cell Mol Physiol. 2010 Jul;299(1):L36-50. Epub 2010
Apr 9.
5. Walsh MC, Hibbs AM, Martin CR, Cnaan A, Keller RL, Vittinghoff E, Martin RJ,
Truog WE, Ballard PL, Zadell A, Wadlinger SR, Coburn CE, Ballard RA; NO CLD
Study Group. Two-year neurodevelopmental outcomes of ventilated preterm infants
treated with inhaled nitric oxide. J Pediatr. 2010 Apr;156(4):556-61.e1. Epub 2010 Feb
6.
Ballard, Roberta
1. Golombek SG, Truog WE, Ballard RA, Ballard PL. Re: 'The use of iNO in the newborn
period: results from the European iNO registry'. Acta Paediatr. 2010 Sep;99(9):1283.
doi: 10.1111/j.1651-2227.2010.01847.x. No abstract available.
2. Askie LM, Ballard RA, Cutter G, Dani C, Elbourne D, Field D, Hascoet JM, Hibbs AM,
Kinsella JP, Mercier JC, Rich W, Schreiber MD, Srisuparp P, Subhedar NV, Van Meurs
KP, Voysey M, Barrington K, Ehrenkranz RA, Finer N; Meta-Analysis of Preterm Patients on inhaled Nitric Oxide (MAPPiNO) Collaboration. Inhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysis. BMC Pediatr. 2010 Mar 23;10:15. Review.
3. Walsh MC, Hibbs AM, Martin CR, Cnaan A, Keller RL, Vittinghoff E, Martin RJ,
Truog WE, Ballard PL, Zadell A, Wadlinger SR, Coburn CE, Ballard RA; NO CLD
Study Group. Two-year neurodevelopmental outcomes of ventilated preterm infants
treated with inhaled nitric oxide. J Pediatr. 2010 Apr;156(4):556-61.e1. Epub 2010 Feb
6.
4. Hibbs AM, Black D, Palermo L, Cnaan A, Luan X, Truog WE, Walsh MC, Ballard RA.
Accounting for multiple births in neonatal and perinatal trials: systematic review and case
study. J Pediatr. 2010 Feb;156(2):202-8. Epub 2009 Dec 6. Review.
Bonifacio, Sonia
1. Bonifacio SL, Glass HC, Peloquin S, Ferriero DM. A new neurological focus in neonatal
intensive care. Nature Reviews Neurology. Accepted July 2011.
2. Glass HC, Nash K, Bonifacio SL, Sullivan J, Barkovich AJ, Ferriero DM, Cilio MR. Seizures and MRI brain injury in newborns cooled for hypoxic ischemic encephalopathy.
Journal of Pediatrics, Accepted July 2011.
3. Glass HC, Bonifacio SL, Shimotake T, Ferriero DM. Neurocritical Care for Neonates.
Current Treatment Options Neurology. Accepted June 2011.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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4. Harbert MJ, Tam EW, Glass HC, Bonifacio SL, Haeusslein LA, Barkovich AJ, Glidden
DV, Ferriero DM. Hypothermia is Correlated with Seizure Absence in Perinatal Stroke.
Journal of Child Neurology. 2011 Jun 23.
5. Xu D, Bonifacio SL, Charlton NN, P Vaughan C, Lu Y, Ferriero DM, Vigneron DB,
Barkovich AJ. MR spectroscopy of normative premature newborns. J Magn Reson Imaging. 2011 Feb;33(2):306-11. doi: 10.1002/jmri.22460.
6.
Bonifacio SL, Glass HC, Vanderpluym J, Agrawal AT, Xu D, Barkovich AJ, Ferriero
DM. Perinatal events and early magnetic resonance imaging in therapeutic hypothermia.
J Pediatr. 2011 Mar;158(3):360-5. Epub 2010 Oct 20.
7. Bonifacio SL, Glass HC, Chau V, Berman JI, Xu D, Brant R, Barkovich AJ, Poskitt KJ,
Miller SP, Ferriero DM. Extreme premature birth is not associated with impaired development of brain microstructure. J Pediatr. 2010 Nov;157(5):726-32.e1.
8. Glass HC, Bonifacio SL, Peloquin S, Shimotake T, Sehring S, Sun Y, Sullivan J, Rogers
E, Barkovich AJ, Rowitch D, Ferriero DM. Neurocritical care for neonates. Neurocrit
Care. 2010 Jun;12(3):421-9.
Review Articles & Book Chapters
1. Bonifacio SL, Gonzalez FF, Ferriero DM. “Central Nervous System Injury and Neuroprotection” in Avery’s Diseases of the Newborn, 9th edition. Ed. Gleason CA, Devaskar
SU, In Press, 2010
Burt, Trevor
1. Mold JE, Venkatasubrahmanyam S, Burt TD, Michaëlsson J, Rivera JM, Galkina SA,
Weinberg K, Stoddart CA, McCune JM. Fetal and adult hematopoietic stem cells give
rise to distinct T cell lineages in humans. Science. 2010 Dec 17;330(6011):1695-9. Erratum in: Science. 2011 Feb 4;331(6017):534.
2. Burt TD, Seu L, Mold JE, Kappas A, McCune JM. Naive human T cells are activated
and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. J Immunol. 2010 Nov 1;185(9):5279-88. Epub 2010 Oct 4.
Clyman, Ronald
1. Waleh N, Seidner S, McCurnin D, Giavedoni L, Hodara V, Goelz S, Liu BM, Roman
C, Clyman RI. Anatomic Closure of the Premature Patent Ductus Arteriosus: The Role
of CD14+/CD163+ Mononuclear Cells and Vascular Endothelial Growth Factor
(VEGF) in Neointimal Mound Formation. Pediatr Res. 2011 Jun 17. [Epub ahead of
print]
2. Shah NA, Hills NK, Waleh N, McCurnin D, Seidner S, Chemtob S, Clyman R. Relationship between Circulating Platelet Counts and Ductus Arteriosus Patency after Indomethacin Treatment. J Pediatr. 2011 Jun;158(6):919-923.e2. Epub 2010 Dec 30.
3. Waleh N, McCurnin DC, Yoder BA, Shaul PW, Clyman RI. Patent ductus arteriosus
ligation alters pulmonary gene expression in preterm baboons. Pediatr Res. 2011
Mar;69(3):212-6.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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4. Loeliger M, Shields A, McCurnin D, Clyman RI, Yoder B, Inder TE, Rees SM. Ibuprofen treatment for closure of patent ductus arteriosus is not associated with increased risk
of neuropathology. Pediatr Res. 2010 Oct;68(4):298-302.
5. Waleh N, Hodnick R, Jhaveri N, McConaghy S, Dagle J, Seidner S, McCurnin D, Murray JC, Ohls R, Clyman RI. Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency. Pediatr Res.
2010 Oct;68(4):292-7.
6. Jhaveri N, Moon-Grady A, Clyman RI. Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin
treatment. J Pediatr. 2010 Sep;157(3):381-7, 387.e1.
7. Chen S, Tacy T, Clyman R. How useful are B-type natriuretic peptide measurements for
monitoring changes in patent ductus arteriosus shunt magnitude? J Perinatol.
2010;30:780-5. “PMCID: PMC Journal – In Process”
8. Jhaveri N, Soll RF, Clyman RI. Feeding practices and patent ductus arteriosus ligation
preferences-are they related? Am J Perinatol. 2010 Sep;27(8):667-74. Epub 2010 Mar
11.
9. Clyman R, Chemtob S. Vessel remodeling in the newborn: platelets fill the gap. Nat
Med. 2010 Jan;16(1):33-5. No abstract available.
Review Articles & Book Chapters
1. Clyman RI: Patent ductus arteriosus and ductus venosus in the preterm infant. In Rudolph’s Pediatrics, 22nd ed, Rudolph CD, Rudolph AM, Hostetter M, Lister G (eds).
New York, NY, McGraw-Hill Medical Publishing Co., 2011, pp.238-242.
2. Clyman RI: Patent ductus arteriosus in the premature infant. In Avery’s Diseases of the
Newborn, 9th ed, Gleason CA, Devaskar S (eds). Philadelphia, PA, W.B. Saunders Co.,
(in press).
3. Clyman RI: Regulation of the Ductus Arteriosus. In Evidence Based Handbook of Neonatology, Oh W (ed). Singapore, World Scientific Publishing Company (in press).
4. Clyman RI. Reply. J Pediatr, 2010; [Epub ahead of time]
5. Clyman RI: Mechanisms regulating closure of the ductus arteriosus. In Fetal and Neonatal Physiology, 4th ed, Polin R, Fox W, and Abman S (eds). Philadelphia, PA, W.B.
Saunders Co., (in press).
6. Clyman RI, Couto J, Murphy GM. Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? In Seminars in Perinatology: PDA:
Mechanisms and Management, ed Reese J (in press)
7. Noori S, Clyman RI. The very low birthweight neonate with a hemodynamically significant ductus arteriosus during the first postnatal week. In Hemodynamics and Cardiology:
Neonatology Questions and Controversies, Second Edition (eds, Polin R, Kleinman C, Seri
I.
Gonzalez, Fernando
1. Gonzalez FF, Fang A, Ferriero DM. Is erythropoietin the answer? Pediatr Res. 2011
Jan;69(1):2-3. No abstract available.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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2. Spadafora R, Gonzalez FF, Derugin N, Wendland M, Ferriero D, McQuillen P. Altered
fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal
stroke. Dev Neurosci. 2010 Jul;32(2):101-13. Epub 2010 May 4.
3. Gonzalez FF, Ferriero DM. Neuroprotection in the newborn infant. Clin Perinatol. 2009
Dec;36(4):859-80, vii. Review.
Gregory, George
1. Politis GD, Schneider WJ, Van Beek AL, Gosain A, Migliori MR, Gregory GA, Fisher
QA, Flick R. Guidelines for pediatric perioperative care during short-term plastic reconstructive surgical projects in less developed nations. Anesth Analg. 2011 Jan;112(1):18390. No abstract available.
Hawgood, Sam
1. Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P,
Nobuhara KK, Hawgood S, Fineman JR. Congenital diaphragmatic hernia: endothelin-1,
pulmonary hypertension, and disease severity. Am J Respir Crit Care Med. 2010 Aug
15;182(4):555-61. Epub 2010 Apr 22.
2. T. Madan, Reid KB, Clark H, Singh M, Nayak A, Sarma PU, Hawgood S, Kishore U.
Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary
aspergillosis. Mol Immunol. 47(10):1923-30, 2010.
Keller, Roberta
1. Jancelewicz T, Vu LT, Keller RL, Jelin EB, Bratton BJ, Townsend TC, Nobuhara KK.
Outcomes of multigestational pregnancies affected by congenital diaphragmatic hernia. J
Pediatr Surg. 2010 Sep;45(9):1753-8.
2. Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P,
Nobuhara KK, Hawgood S, Fineman JR. Congenital diaphragmatic hernia: endothelin1, pulmonary hypertension, and disease severity. Am J Respir Crit Care Med. 2010 Aug
15;182(4):555-61. Epub 2010 Apr 22.
3. Walsh MC, Hibbs AM, Martin CR, Cnaan A, Keller RL, Vittinghoff E, Martin RJ,
Truog WE, Ballard PL, Zadell A, Wadlinger SR, Coburn CE, Ballard RA; NO CLD
Study Group. Two-year neurodevelopmental outcomes of ventilated preterm infants
treated with inhaled nitric oxide. J Pediatr. 2010 Apr;156(4):556-61.e1. Epub 2010 Feb
6.
4. Jancelewicz T, Vu LT, Keller RL, Bratton B, Lee H, Farmer D, Harrison M, Miniati D,
Mackenzie T, Hirose S, Nobuhara K. Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution. J Pediatr Surg. 2010
Jan;45(1):155-60; discussion 160.
Review Articles & Book Chapters
1. Keller RL. “Management of the Infant with Congenital Diaphragmatic Hernia” in The Newborn
Lung: Neonatology Questions and Controversies, 2nd edition. Ed. Bancalari E, In Press, 2011.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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2. Keller RL, Ballard RA. “Bronchopulmonary Dysplasia” in Avery’s Diseases of the Newborn, 9th edition. Ed. Gleason CA, Devaskar SU, In Press, 2010.
3. Keller RL, Guevara-Gallardo S, Farmer DL. “Surgical Disorders of the Chest and Airways” in Avery’s Diseases of the Newborn, 9th edition. Ed. Gleason CA, Devaskar SU, In
Press, 2010.
4. Keller RL. “Congenital Diaphragmatic Hernia” in Pediatric Pulmonary Hypertension. Ed.
Beghetti M, In Press, 2010.
John Clements, Joe Kitterman and George Gregory. 2011 Tooley-Berg dinner.
Kitterman, Joseph
1. Kaplan FS, Zasloff MA, Kitterman JA, Shore EM, Hong CC, Rocke DM. Early mortality and cardiorespiratory failure in patients with fibrodysplasia ossificans progressiva. J
Bone Joint Surg Am. 2010 Mar;92(3):686-91.
Alan Shotkin, Director of Santa Rosa Memorial Hospital ICN, Mike Kuzniewicz, of UCSF
and Kaiser Perminente Division of Research
and Jennifer Hom.
Kuzniewicz, Michael
1. Erickson SE, Vasilevskis EE, Kuzniewicz MW, Cason BA, Lane RK, Dean ML, Rennie
DJ, Dudley RA. The effect of race and ethnicity on outcomes among patients in the intensive care unit: a comprehensive study involving socioeconomic status and resuscitation preferences. Crit Care Med. 2011 Mar;39(3):429-35.
2. Vasilevskis EE, Kuzniewicz MW, Cason BA, Lane RK, Dean ML, Clay T, Rennie DJ,
Dudley RA. Predictors of early postdischarge mortality in critically ill patients: a retrospective cohort study from the California Intensive Care Outcomes project. J Crit Care.
2011 Feb;26(1):65-75. Epub 2010 Aug 16.
3. Usatin D, Liljestrand P, Kuzniewicz MW, Escobar GJ, Newman TB. Effect of neonatal
jaundice and phototherapy on the frequency of first-year outpatient visits. Pediatrics.
2010 Apr;125(4):729-34. Epub 2010 Mar 15.
Lee, Henry
1. Lee HC, Ramachandran P, Madan A. Morbidity risk at birth for Asian Indian Small for
Gestational Age Infants. American Journal of Public Health. 2010; 100(5):820-822.
2. Blumenfeld Y, Lee HC, Pullen K, Wong A, Pettit K, Taslimi M. Ultrasound Estimation
of Fetal Weight in Small for Gestational Age Pregnancies. Journal of Maternal-Fetal &
Neonatal Medicine. 2010; 23(8):790-793.
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3. Lee HC, Chitkara R, Halamek LP, Hintz SR. A National Survey of Pediatric Residents
and Delivery Room Training Experience. Journal of Pediatrics. 2010; 157(1):158-161.
4. Lee HC, Hintz SR, Tyson JE, Parikh NA, Langer J, Gould JB. Prediction of Mortality
for Extremely Premature Infants in a Population Based Cohort. Pediatrics. 2010;
126(3):e644-650.
5. Lee HC, Subeh M, Gould JB. Low Apgar Score and Mortality in Extremely Preterm
Neonates Born in the United States. Acta Paediatrica. 2010; 99(12):1785-1789.
6. Blumenfeld YJ, Lee HC, Gould JB, Langen ES, Jafari A, El-Sayed YY. The Effect of Preterm Premature Rupture of Membranes on Neonatal Mortality Rates. Obstetrics & Gynecology. 2010; 116(6):1381-6.
7. Wirtschafter D, Powers R, Pettit J, Lee HC, Boscardin WJ, Subeh M, Gould JB. Nosocomial Infection Reduction in Very Low Birth Weight Infants with a Statewide Quality
Improvement Model. Pediatrics. 2011; 127(3):419-426.
8. Lee HC, Lyndon A. Blumenfeld YJ, Dudley RA, Gould JB. Antenatal Steroid Administration for Premature Infants in California. Obstetrics & Gynecology. 2011;
117(3):603-609.
9. Miller SS, Lee HC, Gould JB. Hypothermia in very low birth weight infants: distribution,
risk factors, and outcomes. Journal of Perinatology. 2011; 31(Suppl 1):S49-56.
10. McCallie KR, Lee HC, Mayer O, Cohen RS, Hintz SR, Rhine WD. Improved outcomes
with a standardized feeding protocol for very low birth weight infants. 2011; 31(Suppl
1):S61-7.
11. Lee HC, Chien AT, Bardach NS, Clay T, Gould JB, Dudley RA. The Impact of Statistical Choices on Neonatal Intensive Care Unit Quality Ratings Based on Nosocomial Infection Rates. Archives of Pediatric & Adolescent Medicine. 2011; 165(5):429-434.
Review Articles and Book Chapters:
1. Lee HC, Gould JB. Epidemiology of Breech Delivery. In: Textbook of Perinatal Epidemiology. E Sheiner, ed., Nova Science Publishers. 2010
2. Sridhar S, Arguello S, Lee HC. Transition to Oral Feeding in Preterm Infants. NeoReviews. 2011 12(3):e141-147.
3. Lee HC, Madan A. Hematologic Problems of the Newborn. In: Rudolph’s Pediatrics,
22nd Ed. Rudolph, Rudolph, Lister, First, Gershon (eds.) McGraw-Hill Medical Publishing Co. 2011
I
ICN social worker Stephanie Berman, Emin Maltepe and wife Linda Chang. 2011
Tooley-Berg dinner.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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Maltepe, Emin
1. Hunkapiller NM, Gasperowicz M, Kapidzic M, Plaks V, Maltepe E, Kitajewski J, Cross
JC, Fisher SJ. A role for Notch signaling in trophoblast endovascular invasion and in the
pathogenesis of pre-eclampsia. Development. 2011 Jul;138(14):2987-98.
2. Park AM, Sanders TA, Maltepe E. Hypoxia-inducible factor (HIF) and HIF-stabilizing
agents in neonatal care. Semin Fetal Neonatal Med. 2010 Aug;15(4):196-202. Epub
2010 Jul 4. Review.
3. Maltepe E, Bakardjiev AI, Fisher SJ. The placenta: transcriptional, epigenetic, and physiological integration during development. J Clin Invest. 2010 Apr 1;120(4):1016-25. doi:
10.1172/JCI41211. Epub 2010 Apr 1. Review.
4. Delle Piane, L., Lin, W., Liu, X., Donjacour, A., Minasi, P., Revelli, A., Maltepe, E. and
Rinaudo, P. Effect of the method of conception and embryo transfer procedure on mid
gestation placenta and fetal development in a IVF mouse model. Human Repr. 2010
Aug;25(8):2039-46. Epub 2010 Jun 24.
Martinez, Alma
1. Weiner E, Billamay S, Partridge JC, Martinez A. Antenatal Education for Expectant
Mothers Results in Sustained Improvement in Knowledge of Newborn Care. Journal of
Perinatology 2010 Aug 5. (Epub ahead of print).
2. Genzel-Borociczeny O, Hempelman J, Zoppelli L, Martinez A. Predictive value of the 1minute Apgar score for survival at 23 to 26 weeks gestational age. Acta Paediatrica 2010
Jul 28. (Epub ahead of print).
McCulley, David
1. Agarwal P, Verzi MP, Nguyen T, Hu J, Ehlers ML, McCulley DJ, Xu SM, Dodou E,
Anderson JP, Wei ML, Black BL. The MADS box transcription factor MEF2C regulates
melanocyte development and is a direct transcriptional target and partner of SOX10.
Development. 2011 Jun;138(12):2555-65.
2. Blow MJ, McCulley DJ, Li Z, Zhang T, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry
M, Wright C, Chen F, Afzal V, Bristow J, Ren B, Black BL, Rubin EM, Visel A, Pennacchio LA. ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet.
2010 Sep;42(9):806-10. Epub 2010 Aug 22.
Partridge, Colin
1. Weiner EA, Billamay S, Partridge JC, Martinez AM. Antenatal education for expectant
mothers results in sustained improvement in knowledge of newborn care. J Perinatol.
2011 Feb;31(2):92-7. Epub 2010 Aug 5.
Review Articles & Book Chapters
1. Partridge JC, Swaiman KF, Ashwal S, Ferriero DM. Pain management and palliative
care. In: Pediatric Neurology; Principles and Practice 5th edition. (eds) Mosby Elsevier,
Philadelphia, PA. (In press, 2011)
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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Petryniak, Magda
1. Potter GB, Rowitch DH, Petryniak MA. Myelin restoration: progress and prospects for
human cell replacement therapies. Arch Immunol Ther Exp (Warsz). 2011
Jun;59(3):179-93. Epub 2011 Apr 2.
2. Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien AC, Fu H, Petryniak MA, Potter GB, Liu Z, Powers JF, Runquist IS, Rowitch DH, Stiles CD. Phosphorylation state
of Olig2 regulates proliferation of neural progenitors. Neuron. 2011 Mar 10;69(5):90617.
Piecuch, Robert
1. Tam EW, Rosenbluth G, Rogers EE, Ferriero DM, Glidden D, Goldstein RB, Glass
HC, Piecuch RE, Barkovich AJ. Cerebellar hemorrhage on magnetic resonance imaging
in preterm newborns associated with abnormal neurologic outcome. J Pediatr. 2011
Feb;158(2):245-50. Epub 2010 Sep 15.
2. Mercier CE, Dunn MS, Ferrelli KR, Howard DB, Soll RF; Vermont Oxford Network
ELBW Infant Follow-Up Study Group. Neurodevelopmental outcome of extremely low
birth weight infants from the Vermont Oxford network: 1998-2003. Neonatology. 2010
Jun;97(4):329-38. Epub 2009 Nov 24. Erratum in: Neonatology. 2010;98(4):419.
Rogers, Elizabeth
1. Tam EW, Rosenbluth G, Rogers EE, Ferriero DM, Glidden D, Goldstein RB, Glass
HC, Piecuch RE, Barkovich AJ. Cerebellar hemorrhage on magnetic resonance imaging
in preterm newborns associated with abnormal neurologic outcome. J Pediatr. 2011
Feb;158(2):245-50. Epub 2010 Sep 15.
2. Glass HC, Bonifacio SL, Peloquin S, Shimotake T, Sehring S, Sun Y, Sullivan J, Rogers
E, Barkovich AJ, Rowitch D, Ferriero DM. Neurocritical care for neonates. Neurocrit
Care. 2010 Jun;12(3):421-9.
Rowitch, David
1. N. Sanai, T. Nguyen, R.A. Ihrie, Z. Mirzadeh, H-H. Tsai, M. Wong, N. Gupta, M. S.
Berger, E. Huang, J-M. Garcia-Verdugo, D. H. Rowitch* and A. Alvarez-Buylla. Corridors of Migratory Neurons in Human Brain and Their Depletion During Infancy. Nature, In press.
2. V. M. Heine, A. Griveau, C. Chapin, P. L. Ballard, J. K. Chen and D. H. Rowitch*
(2011) Small Molecule Smoothened Agonist Prevents Glucocorticoid-induced Neonatal
Cerebellar Injury. Science Translational Medicine, In press.
3. Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH*. Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci. 2011 Jun 26.
doi: 10.1038/nn.2855. [Epub ahead of print].
4. Mehta S, Huillard E, Kesari S, Maire CL, Golebiowski D, Harrington EP, Alberta JA,
Kane MF, Theisen M, Ligon KL, Rowitch DH*, Stiles CD. The central nervous systemrestricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell. 2011 Mar 8;19(3):359-71.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
26
5. Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien AC, Fu H, Petryniak MA, Potter GB, Liu Z, Powers JF, Runquist IS, Rowitch DH*, Stiles CD. Phosphorylation state
of Olig2 regulates proliferation of neural progenitors. Neuron. 2011 Mar 10;69(5):90617.
6. Monje M, Mitra SS, Freret ME, Raveh TB, Kim J, Masek M, Attema JL, Li G, Haddix
T, Edwards MS, Fisher PG, Weissman IL, Rowitch DH, Vogel H, Wong AJ, Beachy
PA. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma.
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4453-8. Epub 2011 Mar 1.
7. Cole FS, Alleyne C, Barks JD, Boyle RJ, Carroll JL, Dokken D, Edwards WH, Georgieff
M, Gregory K, Johnston MV, Kramer M, Mitchell C, Neu J, Pursley DM, Robinson
WM, Rowitch DH. NIH Consensus Development Conference statement: inhaled nitricoxide therapy for premature infants. Pediatrics. 2011 Feb;127(2):363-9. Epub 2011 Jan
10.
8. Otero JJ, Rowitch D*, Vandenberg S. OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms. J Neurooncol. 2010 Dec 31. [Epub ahead of
print]
9. Cole FS, Alleyne C, Barks JD, Boyle RJ, Carroll JL, Dokken D, Edwards WH, Georgieff
M, Gregory K, Johnston MV, Kramer M, Mitchell C, Neu J, Pursley DM, Robinson W,
Rowitch DH. NIH Consensus Development Conference: Inhaled Nitric Oxide Therapy
for Premature Infants. NIH Consens State Sci Statements. 2010 Oct 29;27(5). [Epub
ahead of print]
10. Harrington EP, Zhao C, Fancy SP, Kaing S, Franklin RJ, Rowitch DH*. Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination. Ann Neurol.
2010 Nov;68(5):703-16.
11. Biran V, Heine VM, Verney C, Sheldon RA, Spadafora R, Vexler ZS, Rowitch DH, Ferriero DM. Cerebellar abnormalities following hypoxia alone compared to hypoxicischemic forebrain injury in the developing rat brain. Neurobiol Dis. 2011
Jan;41(1):138-46. Epub 2010 Sep 16.
12. Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D'Souza C, Fouse SD, Johnson
BE, Hong C, Nielsen C, Zhao Y, Turecki G, Delaney A, Varhol R, Thiessen N, Shchors
K, Heine VM, Rowitch DH, Xing X, Fiore C, Schillebeeckx M, Jones SJ, Haussler D,
Marra MA, Hirst M, Wang T, Costello JF. Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature. 2010 Jul 8;466(7303):253-7.
13. Zawadzka M, Rivers LE, Fancy SP, Zhao C, Tripathi R, Jamen F, Young K, Goncharevich A, Pohl H, Rizzi M, Rowitch DH, Kessaris N, Suter U, Richardson WD, Franklin
RJ. CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell. 2010 Jun 4;6(6):578-90.
14. Heine VM, Priller M, Ling J, Rowitch DH*, Schüller U. Dexamethasone destabilizes
Nmyc to inhibit the growth of hedgehog-associated medulloblastoma. Cancer Res. 2010
Jul 1;70(13):5220-5. Epub 2010 Jun 8.
15. de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S,
Stegmüller J, Schüller U, Salih DA, Rowitch D, Brunet A, Bonni A. A FOXO-Pak1
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27
transcriptional pathway controls neuronal polarity. Genes Dev. 2010 Apr 15;24(8):799813.
16. Schiffman JD, Hodgson JG, VandenBerg SR, Flaherty P, Polley MY, Yu M, Fisher PG,
Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD. Oncogenic BRAF
mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant
astrocytomas. Cancer Res. 2010 Jan 15;70(2):512-9. Epub 2010 Jan 12.
17. Glass HC, Bonifacio SL, Peloquin S, Shimotake T, Sehring S, Sun Y, Sullivan J, Rogers
E, Barkovich AJ, Rowitch D, Ferriero DM. Neurocritical care for neonates. Neurocrit
Care. 2010 Jun;12(3):421-9.
Review Articles & Book Chapters
1. Fancy SP, Chan JR, Baranzini SE, Franklin RJ, Rowitch DH. Myelin regeneration: a
recapitulation of development? Annu Rev Neurosci. 2011;34:21-43.
2. Rowitch DH, Lo B. Role of academic medical centers in cell-based therapeutic clinical
trials. Transl Res. 2011 May;157(5):320-1. Epub 2011 Jan 25. No abstract available.
3. Potter GB, Rowitch DH, Petryniak MA. Myelin restoration: progress and prospects for
human cell replacement therapies. Arch Immunol Ther Exp (Warsz). 2011
Jun;59(3):179-93. Epub 2011 Apr 2.
4. Rowitch DH, Kriegstein AR. Developmental genetics of vertebrate glial-cell specification. Nature. 2010 Nov 11;468(7321):214-22. Review.
5. Silbereis JC, Huang EJ, Back SA, Rowitch DH. Towards improved animal models of
neonatal white matter injury associated with cerebral palsy. Dis Model Mech. 2010 NovDec;3(11-12):678-88.
6. Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH, Franklin RJ.
Overcoming remyelination failure in multiple sclerosis and other myelin disorders. Exp
Neurol. 2010 Sep;225(1):18-23. Epub 2010 Jan 4. Review.
Neonatal ophthalmologist, Bill Good, with
pediatrician Bill Gonda, husband of Sally
Sehring. 2011 Tooley-Berg dinner.
Sehring, Sally
1. Glass HC, Bonifacio SL, Peloquin S, Shimotake T, Sehring S, Sun Y, Sullivan J, Rogers
E, Barkovich AJ, Rowitch D, Ferriero DM. Neurocritical care for neonates. Neurocrit
Care. 2010 Jun;12(3):421-9.
Shimotake, Thomas
1. Glass HC, Bonifacio SL, Peloquin S, Shimotake T, Sehring S, Sun Y, Sullivan J, Rogers
E, Barkovich AJ, Rowitch D, Ferriero DM. Neurocritical care for neonates. Neurocrit
Care. 2010 Jun;12(3):421-9.
Taeusch, William
UCSF Division of Neonatology•www.neonatology.ucsf.edu
28
1.
Lu KW, Pérez-Gil J, Echaide M, Taeusch HW. Pulmonary surfactant proteins and polymer combinations reduce surfactant inhibition by serum. Biochim Biophys Acta. 2011
Jun 27. [Epub ahead of print]
2. Lopez-Rodriguez E, Echaide M, Cruz A, Taeusch HW, Perez-Gil J. Meconium impairs
pulmonary surfactant by a combined action of cholesterol and bile acids. Biophys J. 2011
Feb 2;100(3):646-55.
3. Iwanicki JL, Lu KW, Taeusch HW. Reductions of phospholipase A(2) inhibition of
pulmonary surfactant with hyaluronan. Exp Lung Res. 2010 Apr;36(3):167-74.
4. Lu KW, Taeusch HW. Combined effects of polymers and KL(4) peptide on surface activity of pulmonary surfactant lipids. Biochim Biophys Acta. 2010 Jun;1798(6):1129-34.
Epub 2010 Feb 25.
Ann Zovein with husband Jam. 2011 Tooley-Berg dinner.
Zovein, Ann
1. Hofmann JJ, Zovein AC, Koh H, Radtke F, Weinmaster G, Iruela-Arispe ML. Jagged1
in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into
Alagille syndrome. Development. 2010 Dec;137(23):4061-72.
2. Zovein AC, Turlo KA, Ponec RM, Lynch MR, Chen KC, Hofmann JJ, Cox TC, Gasson
JC, Iruela-Arispe ML. Vascular remodeling of the vitelline artery initiates extravascular
emergence of hematopoietic clusters. Blood. 2010 Nov 4;116(18):3435-44. Epub 2010
Aug 10.
3. Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman
I, Lane TF, Iruela-Arispe ML. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell. 2010 Jan
19;18(1):39-51.
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