approach to chiral taxanes, molecules received
worldwide importance for their anticancer
properties; first enantiospecific total synthesis of
neopupukeananes, etc.
Representative Publications
• A. Srikrishna, T. J. Reddy and P. P. Kumar,
Synthesis of taxanes-the carvone approach: a simple,
efficient, stereo- and enantioselective synthesis of the
functionalised A-ring, Chem. Commun. 1996, 1369.
• A. Srikrishna, C. V. Yelamaggad and P. P. Kumar,
Rearrangement approaches to sesqui-terpenes
containing contiguous quaternary carbon atoms. Total
synthesis of (±)-myltayl-8(12)-ene and (±)-6epijunicedranol, J. Chem. Soc., Perkin Trans. 1
1999, 2877.
A. Srikrishna
Professor, Ph.D. Univ of Hyderabad (with G.
Mehta), Postdoc. Univ of Chicago (with P.E.
Eaton) and Columbia Univ. (with G. Stork).
• A. Srikrishna and S.J. Gharpure, Enantio-specific
total synthesis of (-)-4-thiocyanatoneo-pupukeanane,
INSA Young Scientist, Zaheer Young Scientist
J. Org. Chem. 2001, 65, 4379.
Award, B. M. Birla Award,
Shanti Swarup Bhatnagar Award, F.A.Sc.,
• A. Srikrishna and K. Anebouselvy, EnantioF.N.A.Sc., F.N.A
specific first total synthesis of (+)-cis, anti, cis-3Tel: 2293-2215 (office); 2360-0550 (home);
hydroxy-1,8,12,12-tetramethyl-4-oxatricycloFax: 2360-0529/2360-0683
[6.4.0.02,6]dodecan-9-yl senecioate,
the
optical
E-mail:ask@orgchem.iisc.ernet.in
antipode of a natural thapsane isolated from Thapsia
villosa, Tetrahedron Lett., 2003, 44, 1031.
Research Interests
rr. Srikrishna's research group is interested
in several aspects of organic synthesis, ranging
from the development of synthetic methodologies
and reagents for regioselective transformations, to
total synthesis of natural products. His group has
developed radical cyclisation and annulation based
strategies for the construction of a variety of
bridged compounds and natural products of
contemporary interest. An efficient, novel and
exclusive formation of a cyclopropane ring via 3exo trig radical cyclisation reaction has been
discovered by his group. Total synthesis of many
natural products containing challenging molecular
architecture and multiple contiguous quaternary
carbon atoms have been accomplished, most
notable being the first racemic as well as
enantiospecific total synthesis of tricyclic thapsane
sesquiterpenes, containing a unique carbon
framework with stereochemical intricacies;
synthesis of epijunicedranol, a sesquiterpene
containing four contiguous quaternary carbon
atoms; initiation of a new, novel and imaginative
•
A. Srikrishna and D. H. Dethe, Enantiospe-cific
first total synthesis and assignment of absolute
configuration of the sesquiterpene (-)-cucumin H,
Org. Lett., 2003, 5, 2295.
O
R-Carvone
Our interests also cover the elucidation of
structure and residual interactions in the
mis-/un-folded states of proteins, to mimic
the undesired conformations accessed by
polypeptides, leading to pathological
diseases like, the Alzheimer’s, and other
amyloidogenic diseases. The unique
elucidation of the protein folding pathway
from a rigid un-folded state is also in the
purview of our research.
Erode N. Prabhakaran
Assistant Professor
PhD : 2000 (IIT Kanpur)
Post doc : Boehringher Ingelheim Post Doctoral
Fellow (J.N.Johnston) IUB; NIH Post Doctoral
fellow (J.M.Scholtz & C.N.Pace) Texas A&M
Tel: 2293-3380
Fax: 2360 0529
Email: eprabhak@orgchem.iisc.ernet.in
Research Interests
We are interested in understanding the
forces and interactions responsible for
polypeptide structure, function, folding
and misfolding at the molecular and the
atomic levels. Such understanding is
crucial for elucidation of the protein
folding mechanism and for curing of
several pathological disorders that
originate from misfolding of proteins.
We use synthetic organic chemistry to
develop structure-constraining tools like
covalent spacers & linkers between main
chain peptides, to freeze polypeptides in
desired conformations whose interactions
will be probed in detail using different
spectroscopic
techniques.
Leadoptimization of structural mimics of
functional domains of biologically
significant enzymes will be done for their
functional mimicry. The development of
small molecule functional mimics will be
the stepping stone for synthesis of artificial
enzymes, which is our long term endeavor.
Our laboratory is equipped for organic
synthesis; for design of constrained
topological mimics of biologically
important protein domains; for solution
and solid phase synthesis of constrained
peptidic and non-peptidic oligomers; for
isolation and characterization of these
peptidic and non-peptidic mimics; and for
assay of biological properties of these
molecules.
Representative Publications
Protein structure, stability and solubility in water
and other solvents. C. Nick Pace; Saul Trevino:
Erode Prabhakaran; J. Martin Scholtz., Phil. Trans.
R. Soc. Lond. B, 2004, 359 (1448), 1225-1234.
Free Radical-Mediated Aryl Amination and its Use
in a Convergent [3+2] Strategy for Enantioselective
Indoline -Amino Acid Synthesis. Viswanathan,
Rajesh; Prabhakaran, Erode N.; Plotkin, Michael
A.; Johnston, Jeffrey N., J. Am. Chem. Soc., 2003,
125, 163-168.
Reverse Turn Induced π-Facial Selectivity during
Polyaniline-Supported Cobalt(II) Salen Catalyzed
Aerobic Epoxidation of N-Cinnamoyl L-Proline
Derived Peptides. Nandy, Jyoti P.; Prabhakaran,
Erode N.; Kumar, Kiran S.; Kunwar, A.C.; Iqbal,
Javed., J. Org. Chem., 2003, 68(5), 1679-1692.
Free Radical Mediated Vinyl Amination: Access to
N,N-Dialkyl Enamines and their β-Stannyl and βThio Derivatives. Prabhakaran, Erode N.; Nugent,
Benjamin M.; Cox, Amie L.; Johnston, Jeffrey N.,
Org. Lett., 2002, 4(24), 4197-4200.
Synthesis of Small Cyclic Peptides via Reverse
Turn Induced Ring Closing Metathesis of
Tripeptides. Prabhakaran, Erode N.; Rao,
Nageshwara I.; Boruah, Anima; Iqbal, Javed., J.
Org. Chem., 2002, 67, 8247-8250.
Representative Publications
Additive induced polymorphous behaviour of a
conformationally locked hexol, G. Mehta, S. Sen,
K. Venkatesan, CrystEngComm.9, 144 (2007).
Structures of Conformationally Locked Cyclitols:
An Analysis of Hydrogen-Bonded Architectures
and their Implications in Crystal Engineering. G.
Mehta, S. Sen, S.S. Ramesh Eur. J. Org. Chem.
423 (2007) (cover picture).
Goverdhan Mehta
Honorary Professor/
CSIR Bhatnagar Fellow
Ph.D. Poona University (with Dr. Sukh Dev)
Shanti Swarup Bhatnagar Prize 1978
FASc, FNA, FRS
Fellow of the Third World Academy of
Sciences; Alexander von Humboldt Research
Award
Tel: 080-2293-2850/2360-2367 (Office)
2293-2200/2360-0254 (Home)
Fax: 080-2360-0936/2360-0529
Email: gm@orgchem.iisc.ernet.in
Research Interests
∗ Total synthesis of complex
natural and non-natural products
∗ Chemistry and reactivity of
strained carbocyclic systems
Total synthesis of the putative structure of the
novel triquinane based sesquiterpenoid natural
product dichomitol. G. Mehta, K. Pallavi,
Tetrahedron Lett. 47, 8355 (2006).
Total synthesis of (+)-Merrilactone, G. Mehta, R.
Singh, Angew. Chem. Int. Ed. Engl. 45, 953
(2006).
A rapid acquisition of the bicyclo[3.3.1]nonan-9one core present in garsubellin A and related
phloroglucins,
G.
Mehta,
M.K.
Bera,
Tetrahedron Lett. 47, 689 (2006).
A sequential RCM/fragmentation protocol
towards chiral, stereodefined medium ring
sesquiterpenoids. A carvone route to E and Z
germacrenes, G. Mehta, R.S. Kumaran,
Tetrahedron Lett. 46, 8831 (2005).
Enantioselective total synthesis of polyketide
natural product (−)-EI-1941-2: A novel
interleukin-converting enzyme (ICE) inhibitor,
G. Mehta, S. Roy, Tetrahedron Lett. 46, 7927
(2005).
A total synthesis of Guanacastepene C, G.Mehta,
K.Pallavi, J.D.Umarye, Chem.Commun. 4456
(2005).
Enantioselective total synthesis of bioactive
natural product Sch 642305: A structurally novel
inhibitor of bacterial DNA primase and HIV-1
Tat transactivation, G. Mehta, H.M. Shinde,
Chem. Commun. 3703 (2005)
First total synthesis of Yanuthones: Novel
farnesylated epoxycyclohexenoid marine natural
products, G. Mehta, S.C. Pan, Tetrahedron Lett.
46, 5219 (2005)
Total synthesis of a novel polyketide natural
product (+)-integrasone, an HIV-1 integrase
inhibitor, G. Mehta, S. Roy, Chem. Commun.
3210 (2005)
Representative Publications
•
“Synthetic multivalent glycoclusters and
their importance to probe intricate
carbohydrate-protein
interactions”,
Srinivas, O.; Jayaraman, N. Proc. Indian
Natl. Sci. Acad. 2005, 71 A, 187-212.
N. Jayaraman
•
“Synthesis and Langmuir studies of
bivalent
and
monovalent
α-Dmannopyranosides with Lectin Con A”,
Narasimha Murthy, B.; Sampath, S.;
Jayaraman, N. Langmuir 2005, 21, 95919596.
•
“Synthesis and reactivity profiles of
phosphinated poly(alkyl aryl ether)
dendrimers”,
Nithyanandhan,
J.;
Jayaraman, N. Tetrahedron 2005, 61,
11184-11191.
•
“Observation of chiral smectic phase
(SmC*)
in
azobenzene
linked
bolaamphiphiles containing free sugars”
Abraham, S.; Paul, S.; Narayan, G.;
Prasad, S. K.; Shankar Rao, D. S.;
Jayaraman, N.; Das, S. Adv. Funct.
Mater. 2005, 15, 1579-1584 (Illustration
in the journal cover picture).
•
“Surface plasmon resonance studies of
bivalent
and
monovalent
α-Dmannopyranoside
glycolipids-lectin
interactions”, Bandaru, N. M.; Voelcker,
N. H.; Jayaraman, N. Glycobiology 2006,
16, 822-832.
•
“Synthesis of large generation poly(ether
imine)
(PETIM)
dendrimers”,
Jayamurugan, G,; Jayaraman, N.
Tetrahedron 2006, 62, 9582-9588.
Associate Professor, Ph.D. IIT Kanpur, (with
Professor S. Ranganathan), Postdoctoral Fellow,
University of Birmingham, England; University
of California, Los Angeles, USA, (with
Professor Sir J.F. Stoddart)
Tel.: 080-2293-2578 (office); 2357-0147 (home)
Fax: 080-2360-0529 (office)
E-Mail: jayaraman@orgchem.iisc.ernet.in
Research Interests
Primary research interests are in the following areas
of
chemical
synthesis
and
studies:
hCarbohydrate Chemistry h Dendrimer Chemistry
h Liquid Crystals
hOrganic Synthesis
h Supramolecular Chemistry
Major focus of research of the group at present are:
• Synthesis of oligosaccharides and cluster
glycosides
• Studies of carbohydrate-protein interactions by
biophysical methods
• Chemical modifications of monosaccharides
• Carbohydrate-based liquid crystals
• Synthesis and studies of new types of
dendrimers
Representative Publications
•
•
K. R. Prabhu
Senior Scientific Officer
Ph.D: IISc, Bangalore
(with Prof. S. Chandrasekaran),
Postdoc: University of Missouri, Columbia, MO,
USA, (With Prof. K. V. Katti, and Prof. W. A.
Volkert)
Tel.: 080-2293-2646 (office); 2360-0039 (home)
Fax: 080-2360-0529 (office)
E-Mail: prabhu@orgchem.iisc.ernet.in
•
•
Research Interests
Dr. Prabhu’s research interests are in the following
areas of chemical synthesis and studies:
hReagents and Methodologies
hOrganophosphorus Chemistry
hOrganic Synthesis
hGreen Chemistry
At present his research work is focused on the
various aspects of organic synthesis with the major
emphasis on synthetic methodology. Synthesis of
phosphorus based chiral and achiral ligands and
their utility in catalytic and biological application is
one of the motifs. Development of catalytic
working model for enantioselective reactions with
different transition metals (Rh, Pd, Ni, Al, Cu, W,
Mo) is another main focused area. Development of
general strategy for the catalytic homogeneous and
heterogeneous reactions in user-friendly methods
and their applications in large-scale reactions under
eco-friendly conditions is another important area of
focus.
•
•
“A
Tandem
Sulfur
Transfer/Reduction/Michael
Addition
Mediated by Benzyltriethylammonium
Tetrathiomolybadate”, Prabhu, K. R.;
Sivananda, P. S., and Chandrasekaran,
S,: Angew. Chem. Int. Ed. Eng., (2000),
39, 4316.
“Unprecedented No Solvent Mediated
Selective Bisaminolysis: Aminopropyl
Phosphine as a Novel Synthon for Air
Stable Bisamido-Bisprimaryphosphines”,
Prabhu, K. R., Gali, H.; Pillarsetty, N.
and Katti, K. V.: J. Am. Chem. Soc.,
(2000), 122, 1554-1555.
“The Chemistry of Tetrathiomolybdate:
Applications in Organic Synthesis”.
Prabhu, K. R.; Devan, N., and
Chandrasekaran, S.; Synlett, (2002), 1762
(Review).
“Selective Reduction of Anomeric
Azides
to
Amines
with
Tetrathiomolybdate: Synthesis of β-DGlycosylamines”, Sridhar, P. R.,
Prabhu, K. R., and. Chandrasekaran ,
S.: J. Org. Chem, (2003), 68(13), 52615264.
“Synthesis of Thioglycosides by
Tetrathiomolybdate Mediated Michael
Additions of Masked Thiolates”: P. R.
Sridhar, P. R.; Prabhu, K. R., and
Chandrasekaran, S, Eur. J. Org. Chem.,
(2004), 4809.
“Unprecedented
Rhodium-mediated
Catalytic Transfer Hydrogenation of a
Phosphonate Functionalized Olefin in
Ecofriendly Media”: Raghuraman, K.,
Pillarsetty, N. , Prabhu, K. R. , Katti, K.
K. and Katti, K. V., Inorganica Chimica
Acta, (2004), 357, 2933
Representative Publications
Enantiodivergent synthesis of both antipodes
of gypsy moth pheromone disparlure. Prasad,
K.R.; Anbarasan, P. J. Org. Chem. 2007 (in
press).
Stereoselective total synthesis of (−)-9-deoxygoniopypyrone. Prasad, K.R.; Dhaware, M. G.
Synlett, 2007 (in press).
Kavirayani R. Prasad
Ph D: National Chemical Laboratory, Pune
(with Dr. N. N. Joshi)
AvH Postdoctoral Fellow : University of
Muenster, Germany (with Prof. Dieter
Hoppe); Temple University, Philadelphia,
USA (with Prof. Franklin A. Davis)
Tel: 2293-2524; Fax: 23600529
Email: prasad@orgchem.iisc.ernet.in
Research Interests
Research in our group is in the area of
organic synthesis with a focus on
developing efficient methods for the
construction of molecular structures
of therapeutic importance. The focus
is on the aspects of construction of CC and C-Heteroatom bond formation
by
means
of
asymmetric
catalysis/synthesis from chiral pool
sources. Natural products of current
interest include styryllactones, insect
pheromones, γ-lactones, polyethers,
Annonaceae acetogenins, indolizidine
and isoquinoline alkaloids.
Stereoselective synthesis of γ-alkyl(aryl)-α,βdihydroxy-γ-butyrolactones and naturally
occurring lipid guggultetrol. Prasad, K.R.;
Chandrakumar, A. Tetrahedron 2007, 63,
1798.
Stereoselective synthesis of (−)-centrolobine.
Prasad, K.R.; Anbarasan, P. Tetrahedron,
2007, 63, 1089.
Stereoselective
synthesis
of
(−)microcarapalide. Prasad, K.R.; Penchalaiah,
K.;
Choudhary,
A.;
Anbarasan,
P.
Tetrahedron Lett, 2007, 48, 309.
Stereoselective synthesis of (−)-muricatacin
from l-(+)-tartaric acid. Prasad, K. R.;
Anbarasan, P. Tetrahedron: Asymmetry,
2006, 17, 2765.
Nucleophilic addition reactions of 1,4diketones derived from tartaric acid:
Synthesis of TADDOL analogues. Prasad, K.R.;
Chandrakumar, A. Synthesis, 2006, 2159.
Stereoselective
synthesis
of
(+)goniothalesdiol. Prasad, K.R.; Gholap, S. L. J.
Org. Chem. 2006, 71, 3643.
Stereoselective synthesis of (+)-boronolide
and (−)-5-epi-boronolide. Prasad, K.R.;
Anbarasan, P. Tetrahedron: Asymmetry,
2006, 17, 1146.
Enantiodivergent synthesis of both antipodes
of hydroxy-exo-brevicomin from L-(+)-tartaric
acid.
Prasad,
K.R.;
Anbarasan,
P.
Tetrahedron, 2006, 62, 8303.
Asymmetric synthesis of α-methoxyarylacetic
acid
derivatives.
Prasad,
K.R.;
Chandrakumar, A. Tetrahedron: Asymmetry
2005, 16, 1897.
Asymmetric synthesis of unsaturated αbenzyloxyaldehydes: An enantioselective
synthesis of (+)-exo-brevicomin. Prasad, K.R.;
Anbarasan, P. Tetrahedron: Asymmetry
2005, 16, 3951.
An expeditious enantiospecific total synthesis
of (+)-7-epi-goniofufurone. Prasad, K.R.;
Gholap, S. L. Synlett, 2005, 2260.
Representative Publications
•
•
•
Santanu Bhattacharya
Professor,
Ph.D. Rutgers (with R.A. Moss);
Postdoc.; MIT (with H.G. Khorana) Swarnajayanti
Fellow (DST), S.S. Bhatnagar Award (CSIR),
F.A.Sc. FNA.
Tel: 2293-2664; Fax: 2360-0529/2360-0683
Email: sb@orgchem.iisc.ernet.in
Research interests
•
•
•
1. Molecular Design:
A. Lipids and their analogues.
B. Nucleic acid targeting/binding/modifying
molecules.
C. Decontamination Reactions in aggregates
D. Biomolecular Sensors
•
•
2. Chemical Biology
A.
B.
C.
D.
Mechanism of Drug action on DNA.
Chemistry of Telomeres.
Membrane Formation and Assembly.
Gene Transfer.
3. Supramolecular Chemistry
Surfactants, Liquid Crystals, Oligomers
Low Molecular Mass Gelators
•
•
•
4. NanoScience & NanoTechnology
A. Nanoparticles and Nanomaterials
B. Gel-Nanocomposites
•
AuNp
C12-L-Ala
C12-L-Ala
+ AuNp
•
P. Chaudhuri, B. Ganguly & S. Bhattacharya
(2007) An Experimental and Computational
Analysis on the Differential Role of the
Positional Isomers of Symmetric Bis-2-(pyridyl)1H-benzimidazoles as DNA Binding Agents. J.
Org. Chem. 72, 1912.
S. Bhattacharya & A. Bajaj (2007) MembraneForming Properties of Pseudoglyceryl Backbone
based Gemini Lipids possessing Oxyethylene
Spacers. J. Phys. Chem. B, 111, 2463.
A. Bajaj, P. Kondiah, & S. Bhattacharya (2007)
Design, Synthesis and in-Vitro Gene Delivery
Efficacies of Novel Cholesterol based Gemini
Cationic Lipids and their Serum Compatibity: A
Structure-Activity Investigation J. Med. Chem.
in press.
S. Bhattacharya, A. Srivastava. & A. Pal (2006)
Modulation of Viscoelastic Properties of Physical
Gels by Nanoparticle Doping: Influence of the
Nanoparticle Capping Agent. Angew Chem.,
Int. Ed. 45, 2934.
S. Bhattacharya & A. Bajaj, (2005) Recent
Advances in Lipid Molecular Design. Curr.
Opin. Chem. Biol. 9(6), 647.
J. Haldar, P. Kondaiah and S. Bhattacharya
(2005) Antimicrobial Properties of Novel
‘Cleavable’ Multi-headed Cationic Surfactants, J.
Med. Chem., 48, 3823.
A. Srivastava, S. Ghorai, A.Bhattacharjya, & S.
Bhattacharya (2005) A Tetrameric Sugar based
Azobenzene that Gels Water at various pH values
and in the presence of salts, J. Org. Chem., 70,
6574.
S. Bhattacharya & V. Praveen Kumar (2005)
Effect of Heteroatom Insertion at the side-chain
of 5-Alkyl-1H-tetrazoles on their Properties as
Catalysts for Ester Hydrolysis at Neutral pH, J.
Org. Chem., 70, 9677.
S. Bhattacharya & J. Haldar (2004) Thermodynamics of Micellization of Multiheaded Singlechain Cationic Surfactants, Langmuir, 20, 7940.
S. Bhattacharya and A. Guliyani, (2003) First
Report of Zn2+ Sensing Exclusively at
Mesoscopic Interfaces” Chem. Commun., 1158.
Y.K. Ghosh, S.S. Visweswariah and S.
Bhattacharya (2002) Advantage of the Ether
Linkage between the positive charge and the
Cholesteryl Skeleton in Cholesterol-based
Amphiphiles as Vectors for Gene Delivery,
Bioconjugate Chem., 13, 378.
J. Haldar, V.K. Aswal, P.S. Goyal and S.
Bhattacharya (2001) Molecular Modulation of
Surfactant Aggregation in Water: Effect of the
Incorporation of Multiple Headgroups on Micellar Properties Angew. Chem. Int. Ed. 40, 1228.
S. Bhattacharya and Y.K. Ghosh (2001) First
Report of Phase Selective Gelation of Oil from
Oil/Water Mixtures. Possible Implications
toward
containing
Oil
Spills
Chem.
Commun.185.
Professor, Ph.D. University of London;
Postdoc.: Cambridge University,
University of Geneva , Max-Planck
Institut fur Strahlenchemie, University of
Montreal.
Selected Publications
Sosale Chandrasekhar
Tel: 2293-2689 (office); 2341-5650
(home); Fax: 2360-0529/2360-0683
Email: sosale@orgchem.iisc.ernet.in
•
•
Research Interests
• Physical Organic Chemistry
• Main-group Organometallic
Chemistry
•
My research interests are
stereoelectronic effects, novel
strategies in asymmetric synthesis,
neighbouring group effects and
design of novel reactions and
molecules.
•
•
Sosale Chandrasekhar and P. Karri,
Aromaticity in azlactone anions and its
significance for the Erlenmeyer
synthesis. Tetrahedron Lett., 2006, 47,
5763-5766.
Sosale Chandrasekhar and P. Karri,
Revised mechanism and improved
methodology
for
the
Perkin
condensation. Resuscitation of the
mechanism involving benzal acetate
and the improbability of the enolate of
acetic anhydride. Tetrahedron Lett.,
2006, 47, 2249-2251.
Sosale Chandrasekhar and S. K.
Gorla, Cis-trans enantiomerism in the
Diels-Alder cycloadducts of 6arylfulvenes with maleic anhydride.
Resolution of the exo adducts via the
N-((1S)-1-(naphth-1-yl)ethyl)imide
derivatives. Assignment of the absolute
configurations based on the crystal
structure of an imide diastereomer.
Tetrahedron: Asymmetry, 2006, 17,
92-98.
Sosale Chandrasekhar, Some recent
developments
in
stereoelectronic
theory. Reevaluations of ALPH and
the
reverse
anomeric
effect.
ARKIVOC, 2005, xiii, 37-66.
Sosale Chandrasekhar, Basis of the
'duplication' strategy for enhancing the
e.e. in chiral resolutions: Proof of the
equivalence of rate and product ratios.
Res. Chem. Intermed., 2005, 31, 779783.
Peptides, Pyrrolo Benzodiazepine class of antitumor antibiotics, Carbohydrate derivatives,
Cyanotoxins, Glycoaminoacids, Glycosidase
Inhibitors etc.
Srinivasan Chandrasekaran
Professor and Chairman,
Division of Chemical Sciences
Tel: +91-80- 22932404; 23602423 (off); 23601269 (home) Fax:+91-80- 2360-0529/2360-2423
E-mail: scn@orgchem.iisc.ernet.in
Ph.D. Madras Univ. (with S. Swaminathan);
Postdoctoral research: Harvard University (with
E.J. Corey) and Syntex, Palo Alto, USA
S.S. Bhatnagar Prize (CSIR), FASc, FNA,
FTWAS
Research interests
Organic Materials
Design and Synthesis of Metallorganic Chemical
Vapor Deposition Precursors for Thin Film
Applications.
Design and Synthesis of New Organic Non-Linear
Optical Materials.
Design and Synthesis of New Organic-Inorganic
Hybrid Materials as Catalysts for Asymmetric
Synthesis
Representative Publications
A. Srikanth, G. Nagendrappa and S.
Chandrasekaran, Catalytic Epoxidation of
Cyclic Vinyl Silanes by Ruthenium (II)
Complexes under Aerobic Conditions,
Tetrahedron, 2003, 59, 7761-7765.
D.
Dhar,
A.
Gedanken
and
S.
Chandrasekaran,
Catalytic
Aerobic
Epoxidation of Olefins by Nanostructured
Amorphous CoO-MCM41, Catalysis Lett,
2003, 86,197-201.
New Synthetic Methodology:
¾
¾
¾
¾
¾
¾
¾
¾
¾
Chemistry of Titanium (III) Tetrahydroborates
and their use in Stereoselective Reductions
Chemistry of Binary Molybdenum-Sulfur
Systems as efficient Sulfur Transfer Reagents
Development of New Protective Groups for
Peptide Synthesis using Mo-S Systems.
Study of Induced Internal Redox Reactions of
Tetrathiomolybdates
New Ruthenium (II) –Bisoxazoline Catalysts
for
Highly
Chemoselective
Aerobic
Epoxidation and for Asymmetric Oxygen
Transfer Reactions
Nanostructured Amorphous Metals / Alloys as
New Catalysts for Cycloalkane Oxidation and
Epoxidation
Hybrid Organic –Inorganic Chiral Catalysts for
Asymmetric Synthesis
Chemistry of Tetraselenotungstates as New
Selenium Transfer Reagents
Stereo – and Regioselective Synthesis of
Aziridino Epoxides
Total Synthesis of Natural Products
Application of the reagents and synthetic
methodologies developed in this laboratory to the
synthesis of natural products particularly Cyclic
P. Ramu Sridhar, K. Chinna Ashalu and
S.Chandrasekaran,Novel Methodology for the
Synthesis of 2-C-Branched Glyco-AminoAcids by Ring Opening of 1,2Cyclopraopanecarboxylated Sugars, Organic
Lett., 2004 ,6 1777-1779.
P. Ramusridhar and S. Chandrasekaran,
Synthesis of Thioglycosides by Michael
Addition of Masked Thiolates mediated by
Tetrathiomolybdate, Eur.J.Org.Chem., 2004,
4809-4815.
D. Suresh Kumar, S.M. Koutha and S.
Chandrasekaran,
Chemistry
of
Tetrathiomolybdate: Aziridine Ring Opening
Reactions and Facile Synthesis of Interesting
Sulfur Heterocycles, J.Am.Chem.Soc., 2005,
127, 12760-12761.
R. Ramesh and S. Chandrasekaran, But-2ynylbisoxycarbonyl Chloride: A Novel C2 –
Symmetric Reagent for the Protection of
Amines and Amino Acids, Organic Lett., 2005,
7, 4947-4950.
Representative Publications
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Uday Maitra
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Professor& Chairman
Ph.D. from Columbia University (with
Ronald Breslow); Postdoctoral Research at
Univ of California at Berkeley (with P.A.
Bartlett). Bhatnagar award, F.A.Sc.
Tel: 080-2360-1968, 2293-2690
Fax: 2360-0529/2360-1968
Email: maitra@orgchem.iisc.ernet.in
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Research Interests
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Bile Acid derived novel dendrimers
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Organogels and Hydrogels
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Molecular sensor design
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Bile acid analogues and their
physical and biological properties
My group explores new chemistry and
supramolecular chemistry using bile acids.
These studies include asymmetric synthesis
using bile acids as chiral auxiliaries, templates
and catalysts; design of molecular receptors;
design and properties of cationic, neutral and
anionic analogs of bile acids; design of
molecular systems to understand π-π and
cation-π interactions etc.
Novel non-spheroidal dendrimers are also
being crafted in our laboratories.
Donor-acceptor interaction promoted gelation
of organic fluids, and novel cationic bile acid
based gelation of aqueous fluids have recently
been discovered in this group. A great deal of
effort is being directed towards understanding
this phenomenon at molecular and
macroscopic levels.
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"Nanoparticle-Gel Hybrid Material
Designed with Bile Acid Analogues",
Shreedhar Bhat and Uday Maitra, Chem.
Mater. 2006, 18, 4224.
"A simple and general strategy for the
design of fluorescent cation sensor beads",
Suvadeep Nath and Uday Maitra,
Organic Lett. 2006, 8, 3239.
"Multiple Chromophore Labeled Novel
Bile Acid Dendrimers for Light
Harvesting", N. Vijayalakshmi and Uday
Maitra, Macromolecules 2006, 39, 7931.
"Selective and Unusual Fluoride Ion
Complexation by A Steriodal Receptor
Using OH...F- and CH...F- Interactions - a
New Motif for Anion Coordination?",
Sanjib Ghosh, Angshuman Roy
Choudhury, Tayur N. Guru Row and
Uday Maitra, Organic Lett. 2005, 7,
1441.
"Structure and Dynamics of a Molecular
Hydrogel Derived from a Tripodal
Cholamide", Samrat Mukhopadhyay,
Uday Maitra, Ira, G. Krishnamoorthy, J.
Schmidt, and Y. Talmon, J. Am. Chem.
Soc. 2004, 126, 15905-15914.
“Hydrogel route to nanotubes of metal
oxides and sulfates”, G. Gundiah, S.
Mukhopadhyay, U.G. Tumkurkar, A.
Govindaraj, Uday Maitra and C.N.R.Rao,
J. Mater. Chem., 2003 13, 2118-2122.
“Pyrene-derived Novel One and Twocomponent Organogelators”, P. Babu
N.M. Sangeetha, P. Vijaykumar, Uday
Maitra, K. Rissanen and A.R. Raju,
Chem. Eur. J. 2003, 9, 1922-1932.
“Hydrophobic Pockets in a Non-polymeric
Aqueous Gel: First Observation of such a
Gelation Process by Color Change”, Uday
Maitra, Samrat Mukhopadhyay, Arnab
Sarkar, Photon Rao and S.S. Indi, Angew.
Chem. Int. Ed. Engl. 2001, 40, 2281-2283.
“Highly Diastereoselective Synthesis of
the 1,1'-Binaphthol Unit on a Bile Acid
Template,” A.K. Bandyopadhyaya, N.M.
Sangeetha and Uday Maitra, J. Org.
Chem. 2000, 65, 8239-8244.