Programme
Wednesday 31 August 2016
11:00 - 13:00
Arrival / Registration with light refreshments
ATC Reception and Foyer
13:00 - 13:10
Opening remarks
ATC Auditorium
13:10 - 16:10
Session 1: Innovation in approaches to drug discovery
Chair: John Overington
ATC Auditorium
13:10 - 13:45
Proteomics meets Chemical Biology: Understanding how
drugs work
Gitte Neubauer
Cellzome/GSK, Germany
1
13:45 - 14:20
Targeting Protein-Protein Interactions in Molecular
Chaperone Networks
Jason Gestwicki
University of California, San Francisco,
United States of America
2
14:20 - 14:35
Selective FKBP51 inhibitors enabled by an induced-fit
mechanism
Felix Hausch
MPI of Psychiatry, Germany
3
14:35 - 15:05
Coffee break
ATC Foyer
15:05 - 15:40
Diversity and Design: New Chemical Probes for Biology
and Medicine
Derek Tan
Memorial Sloan Kettering Cancer Center,
United States of America
4
15:40 - 15:55
Rational discovery of protein-protein interaction
modulators and pro-fluorescent tool compounds
Olli Pentikäinen
University of Jyväskylä, Finland
5
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EMBO Conference: Chemical Biology 2016
15:55 - 16:10
Blending Chemoproteomics and Structural Biology - The
Discovery of a selective EPHA2 inhibitor
Stephanie Heinzlmeir
TU Munich, Germany
16:10 - 16:45
Flash talks (2 min / 1 slide each)
ATC Auditorium
16:45 - 18:30
Poster session I
6
ATC Helices
18:30 - 19:30
Keynote session: Frances Arnold
Chair: Edward Lemke
ATC Auditorium
Innovation by Evolution: Expanding the Enzyme Universe
Frances Arnold
California Institute of Technology, United States of America
19:30 - 20:30
Get together with drinks and snacks
ATC Foyer
20:30
Free evening
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Programme
Thursday 01 September 2016
09:00 - 12:35
Session 2: DNA/RNA/Chemical Epigenetics
Chair: Hiroaki Suga
ATC Auditorium
09:00 - 09:35
RNA methylation in gene expression regulation
Chuan He
University of Chicago, United States of America
8
09:35 - 10:10
Natural and Synthetic Protein and Nucleic Acid
Modifications
Andreas Marx
University of Konstanz, Germany
9
10:10 - 10:25
Probing chromatin signaling on the single-molecule level
10
Beat Fierz
EPFL, Switzerland
10:25 - 10:55
Coffee break
ATC Foyer
10:55 - 11:30
Cap-like structures in bacterial RNA and epitranscriptomic
modification
Andres Jäschke
Heidelberg University, Germany
11
11:30 - 12:05
The function of protein lysine fatty acylation
Hening Lin
Cornell University, United States of America
12
12:05 - 12:20
Development of DNA-binding Fluorescent Probe for
Detection of Histone Deacetylase Activity
Masafumi Minoshima
Osaka University, Japan
13
12:20 - 12:35
Molecular probes for understanding the roles of
mitochondrial superoxide
Richard Hartley
University of Glasgow, United Kingdom
14
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EMBO Conference: Chemical Biology 2016
12:35 - 14:00
Lunch
ATC Foyer
14:00 - 15:40
Session 3: Protein profiling and target validation
Chair: Rolf Breinbauer
ATC Auditorium
14:00 - 14:35
Chemical tools to manipulate bacterial pathogenesis
Stephan Sieber
TU Munich, Germany
15
14:35 - 15:10
Probing and Drugging Protein Lipidation
Edward Tate
Imperial College London, United Kingdom
16
15:10 - 15:25
Activity-Based Profiling of Ubiquitin E3 Ligases
Satpal Virdee
University of Dundee, United Kingdom
17
15:25 - 15:40
Identification of the Molecular Target of an Inducer of
Human Glioblastoma Self-Destruction
Robin Bon
University of Leeds, United Kingdom
18
15:40 - 16:00
Flash talks (2 min / 1 slide each)
ATC Auditorium
16:00 - 16:45
Coffee break & Meet the speakers
ATC Foyer
16:45 - 18:30
Poster session II kindly sponsored by ACS Chemical
ATC Helices
18:30 - 19:30
Keynote session: Horst Kessler
Chair: Peter Gölitz
ATC Auditorium
Development of Subtype Selective Ligands for RGD
Recognizing Integrins and their Application in Medicine
Horst Kessler
Institute for Advanced Study, TU Munich, Germany
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Programme
19:30 - 21:00
Dinner
ATC Canteen
21:00
Free evening
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EMBO Conference: Chemical Biology 2016
Friday 02 September 2016
09:00 - 12:35
Session 4: Peptide and protein engineering
Chair: Christian Hackenberger
ATC Auditorium
09:00 - 09:35
Phage selection of bicyclic peptides for application as
therapeutics
Christian Heinis
EPFL, Switzerland
20
09:35 - 10:10
A RaPID way to discover pseudo-natural peptides for
therapeutic uses
Hiroaki Suga
The University of Tokyo, Japan
21
10:10 - 10:25
Genome-editing at nucleotide resolution
Yongjoo Bill Kim
Harvard University, United States of America
22
10:25 - 10:55
Coffee break
ATC Foyer
10:55 - 11:30
Minimal tags for rapid dual-color live-cell labeling and
super-resolution microscopy
Edward Lemke
EMBL Heidelberg, Germany
23
11:30 - 12:05
Allosteric modulators of transcriptional
activator-coactivator complexes
Anna Mapp
University of Michigan, United States of America
24
12:05 - 12:20
Repurposing the Translational Machinery of E. coli to
Incorporate Beta-amino acids In vivo
Wesley Robertson
Yale University, United States of America
25
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Programme
12:20 - 12:35
N-terminal selective introduction of azides in proteins by
pH-controlled diazotransfer
Sanne Schoffelen
University of Copenhagen, Denmark
26
12:35 - 14:00
Lunch
ATC Foyer
14:00 - 15:40
Session 5: Natural products / second messengers
Chair: Maja Köhn
ATC Auditorium
14:00 - 14:35
The Chemistry of Oxygen Sensing in Humans and Other
Organisms
Christopher Schofield
University of Oxford, United Kingdom
27
14:35 - 15:10
Elucidating the functions and mechanisms of inositol
pyrophosphate messengers with chemical tools
Dorothea Fiedler
Princeton University, United States of America
28
15:10 - 15:20
Bioorthogonal Metal Catalysed Transformation of Dha in
Peptides and Proteins
A. Dowine de Bruijn
University of Groningen, The Netherlands
29
15:20 - 15:30
Cellular Delivery of Protein by Bioreversible Esterification
30
Kalie Mix
UW-Madison, United States of America
15:30 - 15:40
Making the unselective be selective. Efficient synthesis
reveals the first microcystin analog selective for PP2A.
Miriam Fontanillo
EMBL Heidelberg, Germany
15:40 - 16:00
Flash talks (2 min / 1 slide each)
ATC Auditorium
16:00 - 16:45
Coffee break & Meet the speakers
ATC Foyer
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EMBO Conference: Chemical Biology 2016
16:45 - 18:30
Poster session III
ATC Helices
18:30 - 19:30
Keynote session: Giulio Superti-Furga
Chair: Gitte Neubauer
ATC Auditorium
Solute Carriers, Metabolism and Drug Response: a Magic
Triangle
Giulio Superti-Furga
CeMM Center for Molecular Biology of the Austrian Academy
of Sciences, Austria
19:30 - 00:00
Gala dinner and Party
ATC Canteen and Foyer
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Programme
Saturday 03 September 2016
09:00 - 12:00
Session 6: Light-based tools
Chair: Carsten Schultz
ATC Auditorium
09:00 - 09:35
Assembly of Macromolecular Complexes and Cellular
Processes Triggered by Light
Robert Tampé
Johann Wolfgang Goethe-University Frankfurt, Germany
33
09:35 - 10:10
Expanding the imaging toolbox
Jennifer Prescher
University of California, Irvine, United States of America
34
10:10 - 10:25
Interrogating Endogenous Protein Phosphatase Activity
with Rationally Designed Chemosensors
Jon Beck
University of Nebraska- Lincoln, United States of America
35
10:25 - 10:50
Coffee break
ATC Foyer
10:50 - 11:25
Detection of cAMP nano-domains using targeted
FRET-based reporters
Manuela Zaccolo
University of Oxford, United Kingdom
36
11:25 - 11:35
Chemical Tools for Uncovering Lipid Signalling in Insulin
Secreting ß-Cells
Dmytro Yushchenko
EMBL Heidelberg, Germany
37
11:35 - 11:45
Photoswitchable diacylglycerols enable optical control of
protein kinase C
James Frank
LMU Munich, Germany
38
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EMBO Conference: Chemical Biology 2016
11:45 - 12:00
Photoresponsive self-healing supramolecular hydrogels for
light-induced release of bioactive molecules
Zbigniew Pianowski
KIT Karlsruhe, Germany
12:00 - 12:30
Light refreshments
ATC Foyer
12:30 - 13:30
Keynote session: Paul Wender
Chair: Maja Köhn
ATC Auditorium
Translating Nature's Library: Bio-inspired Strategies for
HIV/AIDS Eradication, Alzheimer's Treatment and Drug
Delivery
Paul Wender
Stanford University, United States of America
13:30 - 13:40
Closing remarks
ATC Auditorium
13:40 - 14:10
Packed lunch
ATC Foyer
14:10
Busses to Frankfurt Int. Airport and downtown Heidelberg
Poster removal (Please remember to collect your poster.
Posters which have not been collected will be disposed of
after the meeting.)
Feedback Questionnaire - Check your inbox when the
meeting ends! You will find an email with the link to the
online feedback questionnaire. Please take time to
complete it!
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