Welcome to Anaheim . . . . . . . . . . . . . . . . . . . . 3
InformexUSA Conference Schedule. . . . . . . . . 4
Networking Connects Community. . . . . . . . . . 4
Showcases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
Chemical Educational Foundation
Develops Future Workforce. . . . . . . . . . . . 22
Art of the Party: C&EN-sponsored Fete . . . . . 23
SOCMA Trade Association. . . . . . . . . . . . . . . . . 6
International Membership . . . . . . . . . . . . . . . . 6
Mobile Website Increases Access . . . . . . . . . . . 7
Five Minutes With…
Dr. Trevor Laird, Organic Process
Research & Development. . . . . . . . . . . . . . . 9
Aslam Malik, AFC. . . . . . . . . . . . . . . . . . . . . . . 11
Joseph Chiaroni, Nova Molecular. . . . . . . . . . 17
A packed crowd was on board Tuesday at the InformexUSA welcome reception sponsored by Dixie Chemical Company.
Showcases Focus on
Company Strengths Within Industry
Editor’s Note: This is Part 1 of a 2 part series focusing on
Evonik catalyzes growth
InformexUSA Showcases on Tuesday which featured indus-
With an emphasis on its growth, Evonik’s Tiffany A.
try leaders in briefings aimed at highlighting the company
Grant focused the company’s showcase on an overview
strengths. Part 2 will appear in Thursday’s Show Daily.
See Rx-360 page 5
Tony Uberoi, Gabriel Performance Products . 18
Exhibitors
News. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8–21
Exhibition Map, List of Exhibitors . . . . . . 12–13
Advertiser Index. . . . . . . . . . . . . . . . . . . . . . . . 23
Rx-360 Members Link with Habitat at Informex
W
hen members of Rx-360 made plans for
Valley Habitat for Humanity—was seven homes for
Informex 2013 in Anaheim, they wanted
families in need in southern California. They also hoped to
to accomplish more than their stated
raise more than $10,000 for the organization, which has
mission of monitoring global drug quality. Deciding
a vision of a world where everyone has a decent place to
to repeat a gratifying experience with Habitat for
live. When families are selected to get a home through the
Humanity in New Orleans at Informex 2012, the group
program, each adult in the family volunteers 250 hours to
marshaled their forces Tuesday, ignoring warnings of
help with its construction.
downpours and possible sleet.
The target this time—in partnership with Pomona
Since its inception in 1976, Habitat for Humanity
See Rx-360 page 22
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Welcome to InformEx USA—
The Global Chemical Marketplace
W
e are excited to have you here with us in Anaheim. A full agenda of business
building meetings, discovering new solution providers, knowledge exchange,
and networking awaits, and we hope that you take advantage of all that
InformEx has to offer.
For our 29th edition of the event, we are pleased to welcome 53 new exhibitors to the
show floor—offering more sources and partners of industry innovations to help grow your
business and facilitate your product development plans.
Also, for 32 percent of our audience, this is your first time at InformEx, so please take
the time to review the show directory so you are familiar with the daily schedules and
offerings on the show floor and in the conference. This show daily is a valuable resource
as well for staying informed of late breaking announcements, exciting new products and
keeping abreast of the sessions and trends that will be topics of discussion over the next
few days and in the future. The QR code below will also allow you to access the mobile site
Daniel Read
of the event.
Of special note is the expanded educational component being offered this year, that provides expert insight on the latest
developments and technologies impacting a broad spectrum of our industry. There is something for everyone in this program that
covers key areas of business: Chemical Trends, Pharmaceutical Manufacturing, Regulatory & Compliance, Specialty Chemicals, as
well as several business building and professional development classes.
The Welcome Reception last night hosted by Dixie Chemicals kicked off the ample networking opportunities that are InformEx’s
signature. Even more networking opportunities are in store for you, including the all-inclusive breakfasts and lunches as well as
tomorrow’s cocktail reception. You are invited to partake in the popular Speed Networking sessions today and tomorrow, from 3-4
pm in the Networking Lounge on the show floor. Bring plenty of business cards and look forward to meeting new people from
procurement, purchasing, R&D, and other areas of the business.
As we begin our 2013 event, it is hard not to share some of our plans for 2014. InformEx will be celebrating its 30th
anniversary in Miami, Jan. 22-24, 2014. Miami ranks highly as a desirable and accessible location, and we are confident that this
milestone year will be attractive and rewarding for everyone. Please visit the InformEx Booth 1709, to learn more about incentives
for booking space and sponsorships for this celebratory 2014 event.
We also invite you to stay connected to InformEx throughout the year through our website and active social communities. Yearround it’s a go to source for the latest information and resources for doing business in the ever-changing chemical marketplace.
And if you are sharing your InformEx experience through your social media communities, the event hashtag is #inf13.
It is our honor to host you here in Anaheim. Again, please be sure to take advantage of all the opportunities we have available
for you, and we welcome your insight about your experiences over the next few days. Your honest feedback is important to the
improvement and growth of our flagship event.
We hope you have productive meetings and a rewarding experience,
InformEx USA
Mobile Site
Daniel Read
Portfolio Director
UBM Live
InformEx & Chemical Group
P u b l i s h e d
Publisher Kenneth M. Carroll
Editor Sharon Donovan
Reporter Ilene Schneider
Art Director Connie Hameedi
Photographers Peter Cutts
Advertising Sales USA
Dean Baldwin, Robert LaPointe,
Thomas Scanlan
b y
A m e r i c a n
Europe Uwe Riemeyer,
Paul Barrett, Nadia Liefsoens
Asia Minghua Lu, Angel Zu,
Mai Hashikura, Shigamaro Yatsui,
Faredoon Kuka
Production Manager
Joseph Davis
C h e m i c a l
S o c i e t y
ACS Publications
Advertising Sales Group
480 East Swedesford Road
Wayne, PA 19087
Phone 610.964.8061/Fax
610.964.8071
http://cen.acs.org/onsite.html
3
4
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Conference Schedule—Today
All sessions at Marriott Anaheim
8 am
From Big Pharma to Virtual Biotech: What Do They Really Want in a
Vendor?—Orange County 3
Perspectives on the Specialty Chemical Industry—Orange County 1
The One Sales Test You’re Guaranteed to Fail: Tips to Sell Your Company and
Regional vs. Global Sourcing: When Does Proximity Matter?—Orange
Yourself at a Trade Show—Orange County 2
County 4
Differentiating Yourself From the Competition in the Green Supply Chain—
Orange County 3
Noon
How Your EHS&S System Affects Your Bottom Line—Orange County 1
9 am
Driving Sales Through Research—Orange County 2
The New AIA: Changes to Intellectual Property Rights—Orange County 1
How Does Excipient GMP Certification Protect the Patient?—
Orange County 3
Strategic Outsourcing Partnership: Transactional Working Relationships vs.
Partnership Alliances—Orange County 2
Novel High Resolution XR-Powder Diffraction Protocol for APIs Polymorph
API Sourcing in Emerging Markets—Orange County 3
Contamination—Orange County 4
Part 1: Discovering the Latest Applications of Specialty Chemicals to Drive
Technical Innovation—Orange County 4
1 pm
High Potency APIs—AFC Has Them ‘Under Control’—Orange County 1
11 am
Enabling Green Chemistry and Profitability Through Route Scouting—
Orange County 2
Selling Quality Products to Quality Companies, What is Critical to Know—
Orange County 1
Trace Impurity Control and Resolution—Orange County 3
An Artisan Approach: One Stop Shop vs. Specialty Companies—
Sourcing ADC Development, Manufacturing Services for More Efficient
Orange County 2
Supply Chain—Orange County 4
Connecting the Community
with Networking, Social Media
I
S h o w - a t- a - G l a n c e
nformEx is renowned for its networking opportunities, and this year’s event
W e d n e s d a y ,
once again delivers attendees a full range of opportunities to help facilitate
strategic business relationships, renew old contacts, and mingle amongst peers.
Last night’s Welcome Reception, sponsored by Dixie Chemicals, set the
relationship-building tone. Attendees and exhibitors had the chance to meet
and talk about their expectations for the week ahead and new attendees were
introduced to the InformEx experience.
Today and tomorrow, attendees can also enjoy catered breakfasts and lunches on the
T o d a y
7 am–5:30 pm Registration Open—Lobby C
7:30–10 am Networking Breakfast—Exhibition Floor Hall C & D
8–10 am Morning Conference Sessions—Marriott Anaheim
10–11 am Conference Break/Exhibit Time
9 am–5 pm Exhibits Open—Halls C & D
11am–2 pm Afternoon Conference Sessions—Marriott Anaheim
show floor and near the conference sessions. There is also another cocktail reception on
11:30 am–2 pm Networking Lunch—Exhibition Floor Hall C & D
Thursday night, sponsored by C&EN, in Lobby D of the convention center.
3–4 pm Informex Speed Networking—Networking Lounge
Back by popular demand are the Speed Networking Sessions. Taking place in the
T h u r s d a y ,
Networking Lounge on the show floor from 3–4 pm on Wednesday and Thursday,
F e b r u a r y
these sessions give attendees the chance to meet people in roles such as buying,
7:30 am–5:30 pm Registration Open—Lobby C
sourcing and procurement.
In these high energy and fast paced sessions, participants are encouraged
2 1
7:30–10 am Networking Breakfast—Exhibition Floor Hall C & D
8–10 am Morning Conference Sessions—Marriott Anaheim
to have a short conversation with one person and then switch every few
10–11am
Conference Break/Exhibit Time
minutes throughout the hour. These Speed Networking sessions provide a great way
9 am–5 pm Exhibits Open—Halls C & D
of being introduced to numerous potential customers and suppliers in a short space
11 am–2 pm Afternoon Conference Sessions—Marriott Anaheim
of time, exchanging business cards, and expanding networks and contacts within
11:30 am–2 pm Networking Lunch—Exhibition Floor Hall C & D
the industry.
When not being used for the Speed Networking Sessions, the Networking
3–4 pm Informex Speed Networking—Networking Lounge
5–6:30 pmInformex Networking Reception—Lobby D—
Sponsored by C&EN
Lounge is also a great place for buying teams and attendees to re-connect during
the event and discuss what they have seen and heard at InformEx.
F r i d a y ,
To keep the conversation going after the event, InformEx also has active social
F e b r u a r y
2 2
communities on LinkedIn and Twitter with plenty of discussions and information
8 am–Noon Registration Open—Lobby C
sharing year-round.
7:30–10 am Networking Breakfast—Exhibition Floor Hall C & D
Go to www.informex.com to learn more and join.
If you are tweeting from the event, use #inf13 as your hashtag!
9 am–Noon Exhibits Open—Halls C & D
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
From Showcases page 1
Regis describes long history
of Evonik Industries and the catalysts business line. Evonik’s catalysts line
Regis Technologies described its customer-centric organization with a highly
encompasses a wide range of technologies for various markets, including
qualified and experienced technical staff, outstanding project management team
life sciences and fine chemicals, industrial and petrochemicals and polyolefins.
and the facilities and regulatory experience to ensure success at its showcase
In addition to a proprietary product portfolio, Evonik offers business
presentation. The presentation described Regis’s broad range of services, vast
models to its customers who have toll production requirements or even
chemistry experience and high rate of repeat business, as well as its investment in
requirements for new catalyst technologies that involve joint development.
people, facilities and technologies to better serve the life science community and
Evonik Industries, a leading
5
create a better, safer and more
specialty chemicals companies,
empowering environment for
is an expert in power
its employees.
generation from hard coal and
Regis, a custom API
renewable energies and one of
manufacturer based in the
the largest private residential
Chicago area, is a family
real estate companies in
owned business that has met
Germany. The company’s
the needs of pharmaceutical
performance is shaped by
and related life science
creativity, specialization,
industries for more than 50
continuous self-renewal
years. Its primary mission
and reliability.
is to provide development,
optimization and cGMP
Optima emphasizes fine
chemical capabilities
manufacturing services to
Optima Chemical
commercial needs.
support customers’ clinical and
offers a wide variety of
organophosphines, metal
Company highlights
comprehensive approach
hydrides, and grignards within
Carbogen Amcis’ Scott A.
its well-established boronic
Miller, head of special projects
acid product lines. These
and responsible for the
new products are in line with
company’s Antibody Drug
customer needs and provide
Conjugate business expansion
organometallic, organosilanes,
synergy with Optima’s primary
in Switzerland, described the
business of custom and contract manufacturing business, a company spokesperson
ADCs as key anti-cancer treatment platforms combining an antibody with a highly
said at its showcase presentation.
potent cytotoxic molecule.
Additionally, Optima is now the licensed manufacturer and seller of several kinds
The conjugation of the antibody to the cytotoxic drug via specific linkers
of alkylithiums and lithium alkoxides. Manufacturing capabilities for any for these
poses several challenges during the development and manufacturing phases. The
products range from grams to metric tons.
alliance between Carbogen Amcis and ADC Biotechnology aims to help ADC
Optima continues to focused on the core business of custom manufacturing and
innovators overcome these challenges by offering world-class chemistry skills and
support services for advanced intermediates and fine chemicals to several industries
access to ADC Biotechology’s proprietary solid phase immobilisation technology.
including pharmaceutical, nutraceutical, bioscience, personal care, and food/flavors.
Miller’s presentation included a workshop dedicated to ADCs in Switzerland and a
It is a full service contract/custom synthesis manufacturer offering services over a
formulation site with lyophilization capabilities in France for the supply of ADCs.
comprehensive range of scale.
Helsinn keeps up with trends
WeylChem offers chemicals, manufacturing services
Helsinn Advanced Synthesis develops and manufactures active pharmaceutical
The WeylChem Group, the fine chemicals platform of International Chemical
ingredients (APIs), advanced intermediates, high potency active pharmaceutical
Investors Group, offers custom manufacturing services, as well as
ingredients (HPAPIs) and, most recently, cytotoxic compounds for third parties under
advanced intermediates, reagents, and performance products for the
cGMP on an exclusive basis. The production plants, located in Biasca, Switzerland,
pharmaceutical industry.
were first established in 1983 and have gone through continuous expansions and
Emerging from the recent consolidation of WeylChem and Elgin Fine
Chemicals (former RUETGERS-Organics and Clariant Fine Chemicals custom
renovations to keep up with the latest technology trends.
In 1999, HAS expanded into the HPAPI market and the facilities were expanded
manufacturing businesses, respectively), the combination of expertise in
to include suites that utilized containment technologies. Its highly skilled team has
its fine chemical units and a team of more than 900 people provides
produced numerous HPAPIs in therapeutic areas including: CNS, cardiovascular,
innovative, dynamically developing know-how, according to company’s
respiratory, dermatology, and cancer supportive care. For HPAPIs, production scale is
showcase presentation.
from grams up to hundreds of kilograms.
It provides a wide range of technologies on an exclusive basis for the fine
Since early 2000, the plants have been ISO 14001 certified, confirming Helsinn’s
chemicals market. Core chemistries are based on bromination, chlorination,
commitment towards international environmental protection. The continuous work
fluorination, sulfonation, oxidation, phosgenation; Grignard, Skraup and Sandmeyer
on Health, Safety & Environment (HSE) also led to the OHSAS 18001 certification in
reactions and Friedel-Crafts as well as C-C and Ullman Coupling reactions.
2005, in which HAS was one of the first chemical plants in Switzerland to do so.
6
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Trade Association Membership
Complements Tradeshow Experience
A
driven event,
team, and they’re in
tradeshows like
constant communication
InformexUSA offer exhibitors
with our members,” said
and attendees alike the
Todd Brown, Director of
opportunity to make new
Recruitment and Retention.
business connections and
“Some want the latest
network with key players
information on TSCA
in the fine, specialty
reform, while others call us
and custom chemical
for advice on dealing with
manufacturing industry.
reporters.”
s a networking-
“We have a 30-member
For many, InformexUSA is
Brown says more and
among the many tradeshows
more SOCMA members are
and networking events they
tapping into the expertise
attend throughout the year.
of the association’s staff,
In conjunction with these
which includes former
events, industry executives
U.S. congressional and
also use their trade
EPA staff, journalists,
association membership
marketers and financial and
to strengthen connections
human resources experts.
and develop business
Additionally, SOCMA has
partnerships with those they
several PhD chemists on
meet.
staff and is led by Lawrence
According to American
Sloan, a former chemical
Business Magazine, 85
percent of all business
failures occur in firms that
are not members of their
industry professional.
SOCMA’s Ana Penaranda, left, senior manager of web project management and member services,
and Bill Allmond, right, VP of government and public relations, listen as members share information
about the industry during the 2012 InformexUSA trade show.
“While many companies
typically turn to a trade
association for networking
industry trade association. While networking is among the greatest benefits of
or lobbying assistance, it’s usually the countless other things we do that help them
association membership, there are other advantages, too.
get the most out of their membership,” Brown explained.
Organizations like SOCMA also provide leadership roles within the association,
Brown urges companies to view trade association membership as an extension
access to educational tools and programs, advice and referrals, and the latest news
of their staff. “It’s really about knowing how to tap into the services that are going
on industry drivers, trends and regulations.
to help your company save time and money,” he said. “Sometimes the first step is
As a trade association for specialty manufacturers, SOCMA’s staff in Washington
fields daily calls and emails from members on a variety of issues, big and small.
just picking up the phone and asking someone.”
Visit SOCMA at Booth 2357.
International Companies Find Value in SOCMA Membership
S
pecialty chemical companies around the globe continue to look
(Booth 1800) joined SOCMA at the recommendation of the Italian Trade
to the Society of Chemical Manufacturers and Affiliates
Commission (ITC), which encouraged the companies to expand their
(SOCMA) for the resources they need to grow their business.
business opportunities through SOCMA membership. The companies are
Most recently, four Italian companies and a major oilfield services
also interested in participating in networking events and marketing their
company joined the association to access its resources to network and
businesses through a variety of services, such as SOCMA’s Marketplace
market their products.
and Chemical Services Directory and InformEx.
“We are pleased to welcome this group of new member companies,
Another significant addition to SOCMA’s membership is Weatherford
which demonstrates the diversity and strength of SOCMA’s membership,”
International, one of the world’s largest oilfield services companies.
said SOCMA president and CEO Lawrence D. Sloan. “Our services and
Weatherford (Booth #1358) joined SOCMA because of their emerging
expertise in the specialty chemical industry continue to have value for
chemical operations. Through acquisition and growth, Weatherford has
companies throughout the world, and we encourage our incoming
developed a vigorous Engineered Chemistry group, and they are looking
members to take full advantage of all we have to offer.”
to utilize SOCMA’s Government Relations and ChemStewards programs
Italian companies ZaCh Systems (Booth 1701), Olon SpA (Booth
1703), Flamma (Booth 1802) and Lundbeck Pharmaceuticals Italy S.p.A.
to help them grow their business.
Visit SOCMA at Booth 2357.
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Mobile Website Increased
Access to SOCMA’s Chemical Services Directory
I
directory.
chemical companies market their products and find new business with
with several companies acquiring pieces of business resulting in tens of
greater ease and frequency.
thousands to hundreds of thousands of dollars.
n response to the growing popularity of its Marketplace & Chemical
Services Directory, the Society of Chemical Manufacturers and
The mobile website offers the same information as the online
Affiliates (SOCMA) in 2012 launched a mobile website to help
The directory has been a successful tool for SOCMA members,
The mobile site can be accessed at m.socmachemicaldirectory.com.
Stop by SOCMA Booth #2357 for a demonstration of the Chemical
Since the directory has been operational, for example:
Services Directory. SOCMA is also offering a special three-month trial for
n
50+ business opportunities were posted for members to explore
companies attending InformEx.
n
Another 50 members were contacted directly by potential customers
“The reality is our members and their customers probably spend more
than half their time on the road instead of in front of their PC’s at the
office,” said Dolores Alonso, senior director of member and marketing
directly from their profiles
n
10+ members are currently in some form of negotiation/exploration
with companies that either contacted them or posted an opportunity
services. “They stay connected via smartphones and tablets. With this
”SOCMA’s goal in developing this site is to offer mobile-friendly
mobile version, they can easily navigate through the directory and find
content to the widest possible audience,” said Ana Penaranda, senior
business opportunities while sitting at the airport gate or in between
manager for the web project. “We’ve modified the full-site template
business meetings.”
so it’s now designed for the smaller handheld display and touch-screen
SOCMA’s directory allows users to search a network of chemical
interface, allowing visitors to find information easily. Visitors can also
companies based on more than 400 types of reactions and chemistries. Site
access mobile-specific features such as click-to-call and location-based
visitors can narrow their search by choosing from more than 200 capabilities
mapping.”
and services, as well as equipment and markets served. They can verify a
“SOCMA is the only chemical trade association providing a tool of this
company’s certification in SOCMA’s ChemStewards program, as well as other
kind to the industry,” added Alonso. “Both products were developed with our
performance improvement programs. The directory also allows visitors to buy
members in mind and are part of the broad portfolio of benefits we offer.”
and sell equipment, share documents and exchange ideas.
The directory is free for members and at a cost for non-members.
7
8
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Evonik’s HPAPI Custom Manufacturing
Advantage for Highly Potent Oncology Drugs
Compounds to treat cancer are typically known as highly potent active pharmaceutical ingredients
(HPAPIs) because they generally act at very low concentrations. High potency places substantial
additional requirements on the handling and formulating of HPAPIs. In addition to FDA regulations,
the manufacturer must comply with a large number of worker safety and environmental regulations to
ensure the protection of employees and the environment across areas such as the laboratory, production,
warehousing, and waste treatment facilities. This requires an expertise in regulations, industrial hygiene,
process development, equipment design, as well as materials handling and waste treatment.
Evonik operates total reactor volumes of 135 m3 for ton quantities and 35 m3 for kilogram or
development quantities of HPAPIs. Containment technologies can meet Occupational Exposure Levels
of < 0.1 μg/m3 air (8 hour TWA). In addition, Evonik can go from laboratory to full scale manufacturing
in-house and very quickly.
Evonik has a network of production sites of a size mix that makes them unique in the industry. With
Tippecanoe Laboratories in the U.S., Evonik is now among the few companies worldwide with
significant experience and capacity in the custom manufacturing of HPAPIs at all scales. This U.S.
FDA-inspected site, with over 600 employees, possesses more than 20 years of experience in solving the
problems related to the process development, production, and handling of HPAPIs. With a wide array of
development and manufacturing capabilities in the U.S., such as cryogenic reactions, gas additions, and
catalysis, Evonik can conduct complex synthesis of HPAPIs and their related intermediates including the
synthesis of custom linkers and antibody drug conjugates commonly used in cancer therapy. This HPAPI
expertise is also available in Hanau, Germany, where Evonik recently established a HPAPI process
development laboratory.
Leading Pharma companies trust Evonik to deliver highly potent active ingredients, from the smallest
quantities for clinical trials all the way through commercial scale production.
Visit Evonik at Booth 1239.
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Five Minutes With…
Dr. Trevor Laird
to market faster, but less so on the processes for manufacture (which are often
Editor-in-Chief
outsourced). So there will be a need for second generation process R&D after a
Organic Process
Research &
Development
product has been launched, specifically with the aim of cost reduction.
What is the focus of the journal
entitled Organic Process Research
and Development (OPR&D)?
OPR&D is the only journal that focuses
9
What is OPR&D doing to help chemists and engineers meet/face
their challenges?
The journal provides an information resource on all aspects of process R&D, scale
up and manufacture and each article has some “tricks of the trade” not available
elsewhere in the literature. Thus, it is an aid to problem solving. That is why it is
read cover-to-cover like a magazine, rather than looking at a few papers, as in a
typical journal. The special issues on topics such as crystallisation/polymorphism (Feb
on industrial chemical processes, describing
2013) and on Continuous Processing (2012 and hopefully again in 2014) help those
the R&D and kilogram/tonne scale up that
involved in process R&D and manufacture to keep up-to-date with current thinking.
goes into making a chemical process economic, safe, robust and suitable for making
Each year we have a special safety issue to alert chemists and engineers to plant
high quality products such as pharmaceutical Active Pharmaceutical Ingredients or
incidents and near misses from the past year.
Agrochemicals. OPR&D not only describes high quality science but covers lots of
issues such as regulatory, patents, quality by design, continuous processing, green
chemistry, etc. The journal has special issues devoted to topics of current interest.
Any predictions for the future of your field?
There will be more pressure on cost of goods, even in generic drugs. So
API manufacturers will have to focus even more on cost reduction. This will
What are the major challenges chemists and chemical engineers
face today?
mean devising more innovative synthetic routes from lower cost raw materials,
using more statistical methods of optimization (Design of Experiments, Factorial
The challenge is that molecules coming into development are much more
Designs) in development to get lower cost manufacture, more efforts to improve
complex, yet the market desires lower cost products. So chemists and engineers
process robustness to reduce batch failure and reworks, and designing small scale
have to design better manufacturing processes to help keep the cost down.
continuous processes for more economic manufacture.
Companies (particularly biotechs) are, however, focusing more on getting products
See 5 Minutes With…Organic page 15
10
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Ash Stevens Nears Completion of Multi-year Expansion
Ash Stevens, a full-service contract
the service and capacity needs of most
pharmaceutical manufacturer, is in
projects while still providing close interactive
the final stages of completing a
client support and project management
multi-year, multi-million dollar expansion
to facilitate a successful outsourcing
to its cGMP manufacturing facility in
experience,” said Dr. Stephen Munk,
Riverview, MI. All construction on the project
president and CEO of Ash Stevens. “We have
is now complete.
come a long way over the past 50 years and
The final phase of the expansion involves
are very excited to be completing this latest
the commissioning and validation of a new
phase of expansion at our state-of-the-art
large-scale reactor bay and companion large-
manufacturing facility in Riverview, MI.”
scale isolation bay. Validation activities are
In addition to the large-scale reactor and
scheduled to be complete April 2013. The
isolation bays, Ash Stevens has added many
new large-scale reactor bay houses 2,000,
other upgrades to its Riverview manufacturing
3,000 and 4,000 liter glass-lined vessels
facility since beginning this expansion
equipped with split butterfly valves and
phase in 2006. These upgrades include: a
appropriate engineering controls for potent
hydrogenation reactor bay; a solid-state
compound charging and handling.
characterization laboratory that includes
The new adjacent isolation bay is
DSC, TGA, XRPD and PSD instrumentation;
equipped with a 1.5 m2 fixed filter dryer with
a laboratory with appropriate air handling
glovebox technology for contained isolation,
systems for the synthesis of highly potent
drying, and packaging of large-scale batches.
compounds; a materials storage and handling
This technology permits handling of potent
facility; Rosenmund filter dryers with
compounds and air sensitive materials at
glovebox technology; and a safety and hazard
scale.
assessment laboratory equipped with RC1
“With the completion of the expansion,
Ash Stevens will have the capability to meet
technology.
Visit Ash Stevens at Booth 1552.
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Five Minutes With…
Aslam
Malik
President
the industry is the accelerating pace of growth in the regulatory environment.
Certain approved, planned, and potential EPA & OSHA regulations, while
American Pacific
Fine Chemicals
(AFC)
aimed at increasing public and worker safety, as written could serve to reduce
What are your major concerns
within your market over the next
two years?
U.S. Chemical/Industrial base.
The market for western-based Fine &
Specialty Chemical suppliers has seen an
11
the competitiveness of the U.S. Fine & Specialty Chemicals Industry. Greater
governmental and regulatory entity cooperation with industry & professional
association representatives during the development of these types of regulations
should serve to enhance their effectiveness while limiting the negative impact to the
What innovation (not your own company’s) do you believe has
addressed a problem with creative solutions?
Continuous processing applications to replace batch processes in key
increase in demand as many customers
applications is yielding real improvements in cycle times and yields while reducing
have witnessed challenges from the over
the size and amount of process capital expenditures. The benefits realized through
reliance on perceived cost benefits offered by eastern-based suppliers. This increased
continuous processing can also serve to further bridge the gap between eastern and
demand can serve to encourage capex & other longer term investment by high
western fine chemical production costs.
quality western suppliers and is a critical part of improving our support to our
pharmaceutical and related customers base. However, for these relationships to be
sustainable, our customer base should recognize the critical and potentially delicate
partnership role their western-based supply chain supports and proactively move to
assure long-term assurance of western-based supply.
What should be the common goals within the industry and/or
marketplace?
Our industry should continue to push and endorse the continued formal
harmonization of regulatory and industrial standards both at the definition
and implementation scale. This will serve to assure that manufacturers in one
Among the challenges facing the industry, which one do you think
is the most pressing—and why?
One of the most significant challenges facing the Fine Chemicals segment of
country or region know and understand the requirements and costs for full
compliance across the global marketplace. Our industry should also work
See 5 Minutes With…AFC page 19
2Y-Chem, Ltd, Booth 2405
Aaron Equipment Company, Booth 1424
Aarti Industries Ltd, Booth 1660
ABA Chemicals Corp, Booth 2033
ABCR GmbH & Co KG
Ace Glass, Booth 1913
ACES Pharma Inc, Booth 2043
Aceto Corporation, Booth 1201
Acoris Research Ltd, Booth 2410
ACS Green Chemistry Institute, Booth 1044
Adesis Inc, Booth 1420
Advance Research Chemicals, Inc, Booth 2532
Advanstar Communications, Booth 1053
AGC Chemicals Americas Inc, Booth 1612
Agno Pharma, Booth 2006
Air Liquide Electronics, U.S.L.P, Booth 2415
Albemarle Corporation, Booth 1430
Alfa Aesar, a Johnson Matthey Company, Booth 2310
AllessaChemie GmbH, Booth 2101
AllyChem Co, Ltd, Dalian China, Booth 1408
Almac Group ltd, Booth 1313
Alphora Research Inc, Booth 1406
Altiras Industrial Services, Booth 1529
Alzchem LLC, Booth 1909
Amano Enzyme USA Co Ltd, Booth 2430
AmbioPharm, Inc, Booth 1158
American Custom Drying Co, Booth 1301
American Peptide Company Inc, Booth 1418
AminoLogics Co Ltd, Booth 2059
Ampac Fine Chemicals, Booth 2257
Ampac Fine Chemicals, Booth MR26
AMRI, Booth 1001
Amsyn Inc, Booth 1307
Anthem Biosciences Pvt Ltd, Booth 2201
APC Ltd, The Applied Process Company, Booth 2056
Apollo Scientific, Booth 2161
Apotex Fermentation, Inc, Booth 1344
Aptuit, Booth 1619
ARRAN Chemical Co, Booth 1639
Artisan Industries Inc, Booth 1021
Ash Stevens, Inc, Booth 1552
Ash Stevens, Inc, Booth MR7
A-Star Chemical Co, Ltd, Booth 1219a
Astatech, Inc, Booth 1011
Asymchem Laboratories (Tianjin) Co, Ltd, Booth 2138
Asymchem Laboratories (Tianjin) Co, Ltd, Booth MR25
Aurora Filters, Booth 1150
Austin Chemical Company, Inc, Booth 1225
BASF Corporation, Booth 1439
BASF Corporation, Booth MR3
BCN Peptides SA, Booth 1029
Beijing Century RICHAP Chemistry Co, Ltd,
Booth 1359
Beijing Laviana Pharmatech Co, Ltd, Booth 2124
Beijing Odyssey Chemicals Co, Ltd, Booth 2009
Beijing Tianqing Chemicals.Co,Ltd, Booth 2015
Benzo Chem Industries Pvt. Ltd, Booth 2423C
Bharavi Laboratories, Booth 921H
Biazzi SA, Booth 1758
BioReliance Corporation, Booth 921L
Biovectra Inc, Booth 2156
Boehringer Ingelheim Pharma GmbH & CoKG,
Booth 2351
Boron Molecular USA, Booth 1421
Boron Specialties LLC, Booth 1608
Borregaard Synthesis, Booth 1038
Boulder Scientific Company, Booth 1309
Browz, LLC, Booth 1620
Buchiglas USA Corp, Booth 2301
Buckman Laboratories, Booth 1912
C&EN/ACS Publications, Booth 2447
CABB AG, Booth 2350
CAC Chemical Co Ltd, Booth 1533
CalaChem Ltd, Booth 1119
Calaire Chimie S.A.S., Booth 1501
Cambrex Corporation, Booth 1539
Cambrex Corporation, Booth MR2
Cambridge Major Laboratories, Booth 2225
CAP Intelligence, Booth 2260
CARBOGEN AMCIS AG, Booth 2529
CARBOGEN AMCIS AG, Booth MR36
Carbosynth Ltd, Booth 2423E
Cardolite Corporation, Booth 2221
Carus Corporation, Booth 2423D
CAS, Booth 1009
Catalent Pharma Solutions, Booth 2414
CatSci, Booth 921C
CCPIT Sub-Council of Chemical Industry, Booth 1521
CCR Containers, Booth 1355
Cedarburg Pharmaceuticals Inc, Booth 1207
Cedarburg Pharmaceuticals Inc, Booth MR5
CellMark Chemicals, Booth 1258
Centauri Technologies LP, Booth 1658
Central Glass International, Inc, Booth 2157
Changzhou EST Chemical Co Ltd, Booth 1459
Changzhou Sunlight Fine Chemical Co,Ltd, Booth 2011
Charkit Chemical Corporation, Booth 1649
CHEM Group, Inc, Booth 1746
Chemada / ICL-IP, Booth 1561
ChemCon GmbH, Booth 1501
ChemDesign Products, Inc, Booth 1603
ChemFuture PharmaTech (Jiangsu) Ltd, Booth 2144
Chemglass Life Sciences, Booth 2409
Chemical Week, Booth 1946
Chemicals Incorporated, Booth 1957
CHEMIK Co, Ltd, Booth 1402
Chemindustry.com, Inc, Booth 2028
Chemlex Pharmaceuticals LLC, Booth 2445
ChemNexus Inc, Booth 2230
Chemoswed, Booth 2201
Chempacific Corporation, Booth 1907
Chemspec API Corp., Booth 2450
Chemtura Corp., Booth 1548
Chevron Phillips, Booth 1712
Chifeng Yingfa Pharmaceutical Co, Ltd, Booth 1128
China Chamber of Commerce of Med. & Heal,
Booth 1147a
China National Pharmaceutical Foreign Co,
Booth 2446
Chiral Quest Inc, Booth 1522
Chiral Technologies, Inc, Booth 2432
Chiral Technologies, Inc, Booth MR27
CiNet, Booth 1626
CiVentiChem, LLC, Booth 2153
Clean Harbors Environmental Services, Inc, Booth 1354
Colonial Metals Inc, Booth 2047
CompareNetworks Inc, Booth 1048
Contract Chemicals Ltd, Booth 1447
Corden Pharma International GmbH, Booth 1801
Corning SAS, Booth 933
CorsiTech, Booth 2331
COSMOSS VU Ltd, Booth 2110
CRI, Booth 1644
Crystallics BV, Booth 1252
CU Chemie Uetikon GmbH, Booth 1545
Custom Granular, Inc, Booth 1407
Cymer, LLC, Booth 1744
Dae Hwa Pharmaceutical Co, Ltd, Booth 1047
Daewoong Bio Inc, Booth 1144
Dalchem, Booth 2444
Dalian Joinking BioChemical Tech Co, Ltd,
Booth 1249
Dalian Richfortune Chemicals Co, Ltd, Booth 1206
DanChem Technologies, Inc, Booth 2012
Danyang Wanlong Chemical Co,Ltd, Booth 1214
DavosPharma, Booth 2201
DCAT (Drug, Chemical & Associated Tech,
Booth 1947
Deepwater Chemicals Inc, Booth 1461
DELMAR Chemicals INC, Booth 2049
Digital Specialty Chemicals, Booth 1160
Dishman USA, Booth 2531
Dixie Chemical Company, Inc, Booth 2231
Dottikon Exclusive Synthesis AG (USA), Booth 2119
Dr. M Inc, Booth 1758
Dr. Reddy’s Laboratories Ltd, Booth 1901
Drug Development & Delivery, Booth 1010
DSL Chemicals (Shanghai) Co, Ltd, Booth 1546
DSM Pharmaceutical Products Inc, Booth 1401
DyStar L.P., Booth 1926
Eastar Chemical Corp., Booth 2133
eChinaChem, Inc, Booth 1948
Enzyme Works Inc , Booth 2423B
Enzymicals AG, Booth 1014
Equinox Chemicals, LLC, Booth 1748
Esteve Quimica, S.A., Booth 2238
Euticals, Inc, Booth 1633
Euticals, Inc, Booth MR6
Evonik Degussa Corp, Booth 1239
Evonik Degussa Corp, Booth MR8
Exova, Booth 1119
F.I.S.–Fabbrica Italiana Sintetici SpA, Booth 2049
F.I.S.–Fabbrica Italiana Sintetici SpA, Booth MR28
Far Chemical, Inc, Booth 1139
Fareva, Booth 2046
Farmabios SpA, Booth 1253
Farmhispania S.A., Booth 1259
Federal Equipment, Booth 2030
Fermion Oy, Booth 2231
Ferro Pfanstiehl Laboratories, Booth 2232
Flamma Spa, Booth 1802
FMC Lithium, Booth 1438
Fontarome Chemical Inc, Booth 1351
Frau Pharma srl, Booth 921O
Fuji Chemical Industry Co, Ltd, Booth 1654
Fuji Silysia Chemical Ltd, Booth 2347
FutureFuel Chemical Co, Booth 1653
Fuzhou Sanhe Pharmachem Co, Ltd, Booth 1618
Gabriel Performance Products, Booth 1423
Galbraith Laboratories Inc, Booth 1002
Gelest Inc, Booth 1318
GFS Chemicals Inc, Booth 1930
GL Filtration Ltd, Booth 1150
Grace/Synthetech, Booth 2039
Gran Formosa Inc, Booth 921P
Guangzhou Runhua Food Additive Co, Ltd, Booth 2244
GVK Biosciences Pvt. Ltd, Booth 1509
Halocarbon Products Corp, Booth 1155
Hamari Chemicals Ltd, Booth 2401
Haviland Products Co, Booth 2061
Hebei Chengxin Co, Ltd, Booth 2128
Helsinn Advanced Synthesis SA, Booth 1809
Helsinn Advanced Synthesis SA, Booth MR9
HERBRAND PharmaChemicals GmbH, Booth 1014
Heritage Environmental Services, Booth 2424
Hodogaya Chemical (USA) Inc, Booth 1261
Hongye Chemical Co, Ltd, Booth 2108
Hopax Tawain Chemical Mfg, Booth 1015
Hovione, LLC, Booth 2330
Huaian MDC Pharmaceutical Co, Ltd, Booth 1120
Hubei Greenhome Fine Chemical Co, Ltd, Booth 2248
Hydrite Chemical Co, Booth 1610
ICO Polymers North America, Booth 1621
InChem Corp, Booth 1652
InCon Processing, LLC, Booth 1613
Ind Swift Laboratories Ltd, Booth 1960
Indoco Remedies Ltd, Booth 2253
Indofine Chemical Company Inc, Booth 2206
INFA Group SpA, Booth 1225
Informex Global Pharma Sourcing, Booth 1709
Informex Sales Booth, Booth 1709
Informex Specialty Chemical Forum, Booth 1709
Ingenza Ltd, Booth 1119
Insight High Technology Co, Ltd, JiangSu, Booth 2122
Interchem Corporation, Booth 1501
International Process Plants (IPP), Booth 1908
Iofina Chemical Inc, Booth 2333
IRIX Pharmaceuticals Inc, Booth 1813
IRIX Pharmaceuticals Inc, Booth MR10
IRIX Pharmaceuticals Inc, Booth MR11
ISOCHEM, Booth 1738
Italian Trade Commission, Booth 1705
J&W Pharmlab, Booth 1027
Jan Ramakers Fine Chemicals Consulting, Booth 1119
Jiangsu Huifeng Agrochemical Co, Ltd, Booth 2001
Jiangsu Lanfeng Biochemical Co, Ltd, Booth 2104
Jiangsu Medicines & Health Prod. I&E Gro, Booth 2005
Jiangxi Renming Pharmaceutical Co, Ltd, Booth 2023
Jiangxi Time Chemical Co, Ltd, Booth 1147a
Jinhong Fine Chemicals, Booth 1361
Johann Haltermann Ltd, Booth 2307
Johnson Matthey, Booth 2310
Johnson Matthey, Booth 2311
Johnson Matthey Catalysis and Chiral, Booth 2311
J-Star Research, Inc, Booth 1343
J-Star Research, Inc, Booth MR12
Julabo USA, Inc, Booth 1559
Kalexsyn, Inc, Booth 1552
Kingchem Inc, Booth 1450
Kingfirst Chemical (Nanjing) Co, Ltd, Booth 2246
KMCO Inc, Booth 1929
Kodak Specialty Chemicals, Booth 1742
Lacamas Laboratories Inc, Booth 2325
Lacamas Laboratories Inc, Booth MR13
Laohekou Jinghong Chemical Co, Ltd, Booth 1628
LAUDA-Brinkmann, LP, Booth 1607
Laurus Pvt. Ltd, Booth 1924
Laviana Corp, Booth MR23
LCI Corporation, Booth 2247
Lianhe Chemical Technology Co, Ltd, Booth 1413
Lishui Nanming Chemical Co, Ltd, Booth 2112
LIST USA Inc, Booth 2419
LOBA Chemie PVT Ltd, Booth 2024
Lonza, Booth 1052
Lonza, Booth MR15
Lonza, Booth MR16
Louisiana Chemical Equipment Co, Booth 1345
Louston International Inc, Booth 1700
Lundbeck Pharmaceuticals Italy SpA, Booth 1800
Manchester Tank & Equipment Company, Booth 1153
McGean,Inc, Booth 1511
Metallix,Inc, Booth 1448
MFG Chemical, Inc, Booth 2438
Micromacinazione SA, Booth 1225
Micron Technologies, Booth 2418
Minakem, LLC, Booth 2320
Mitrychem, Booth 1919
Mitsubishi International PolymerTrade, Booth 2500
Mitsui & Co (USA), Inc, Booth 2321
Mitsui & Co (USA), Inc, Booth MR29
Molekula Group, LLC, Booth 2423G
Monomer-Polymer & Dajac Labs, Booth 2045
Morre-tec Industries, Inc, Booth 2107
MP Biomedicals LLC, Booth 1953
MRIGlobal, Booth 1314
MSU Bioeconomy Institute, Booth 2142
Muller Group, Booth 1961
Na Fluorochem(H.K) International Co, Li, Booth 1521
Nagase & Co, Ltd, Booth 2411
Nanjing Pharmatechs, Co, Ltd, Booth 2208
Nantong Kaixin Pharma Chemical Co, Ltd, Booth 1622
Nation Ford Chemical Co, Booth 1518
Navin Fluorine International Ltd, Booth 1409
Neuland Laboratories, Booth 1159
Newreka Green & Synth Technologies Pvt.,
Booth 2423F
Niels Clauson-Kaas A/S, Booth 2201
Norac Pharma, Booth 1039
Noramco, Inc, Booth 1143
Norquay Technology Inc, Booth 1032
Northeast Pharmaceutical Group Co, Ltd, Booth 2100
Nova Molecular Technologies, Inc, Booth 1442
Novasep Inc, Booth 1939
Oakwood Products Inc, Booth 1109
Olon Spa, Booth 1703
OmegaChem, Booth 1023
ONYX Scientific, Booth 1910
Optima Chemical Group, LLC, Booth 1639
Organic Technologies, Booth 1247
Ortec Inc, Booth 1238
Panjin Xingfu Chemical Industrial Co, L, Booth 1553
Parchem Fine & Specialty Chemicals, Booth 2240
Patheon, Booth 1107
Paul O Abbe, Booth 1424
PCAS, Booth 1601
PCAS, Booth MR14
PCI Synthesis, Booth 1059
Pennakem, Booth 2318
PepTech Corp, Booth 2057
Perry Videx LLC, Booth 2327
Pharmachem, Booth 2251
Pharmacore, Inc, Booth 1303
Pharmax, Booth 2224
PharmaZell, Inc, Booth 1253
PHT International Inc, Booth 1419
Pierre Fabre Medicaments, Booth 1353
PIERS, Booth 1950
PII Pharmaceutics International Inc, Booth 2426
Piramal Healthcare, Booth 2439
POLAQUIMIA S.A. DE C.V., Booth 1312
Polypeptide Laboratories, Booth 2127
Polysciences Inc, Booth 1242
Pope Scientific Inc, Booth 1254
Porton Fine Chemicals Ltd, Booth 1453
Powdersize, Inc, Booth 1215
Pressure Chemical Co, Booth 1458
Procos USA (CBC Group), Booth 2226
PYOSA S.A. DE C.V., Booth 1526
Qi-Chem Co Ltd, Booth 1630
Qingdao Union Fine Chemical Co Ltd, Booth 1219b
Quanzhou Sanwei Chemical Industry Co, L,
Booth 2250
R.S.A. Corporation, Booth 1213
Regis Technologies Inc, Booth 1339
Rhodes Technologies, Booth 1706
Ricerca Biosciences, Booth 2060
Rieke Metals, Inc, Booth 2348
RightAnswer.com, Inc, Booth 1624
Robatel Inc, Booth 1352
Robinson Brothers, Booth 2219
Robinson Pharma, Booth 921G
Rockwood Lithium, Booth 1659
Rodman Publishing, Booth 2146
Rohner Inc, Booth 2215
Rondaxe Pharma LLC, Booth 1648
Ropella, Booth 1346
Rx-360, Booth 2152
SABIC Innovative Plastics, Booth 1449
Sai Life Sciences Ltd, Booth 2109
Sai Life Sciences Ltd, Booth MR24
Saltigo GmbH, Booth 2131
Saltigo GmbH, Booth MR30
SantoLubes Mftg., dba Blackman Uhler,
Booth 1920
SAS Institute Inc, JMP Division, Booth 2443
Scottish Development International, Booth 1119
Scynexis Inc, Booth 2339
Senn, Booth 1058
Senn, Booth MR18
Shaanxi Dasheng Pharmaceutical Tech Co, Booth 1110
Shamrock Technologies, Inc, Booth 2423P
Shandong Hexing Pharmacy Co, Ltd, Booth 1212
Shandong Jiuheng Int’l Trade Co, Ltd, Booth 2252
Shanghai AQBioPharma Co, Ltd, Booth 1141
Shanghai Chemspec Corp., Booth 2450
Shanghai Record Pharmaceuticals Co, Ltd, Booth 2029
Shanghai Shyndec(Modern) Pharmaceutical , Booth 1108
Shanghai Sinofluoro Chemicals Co, Ltd, Booth 1631
Shanghai T&W Pharmaceutical Co, Ltd,
Booth 1609
Shenyang Photosensitive Chemical Research,
Booth 2126
Shenzhen Nexconn Pharmatechs Ltd, Booth 921K
Shijiazhuang No 4 Pharmaceutical Co, Ltd,
Booth 1114
Shouguang Fukang Pharmaceutical Co, Ltd,
Booth 1147b
Siegfried (USA), Inc, Booth 1101
Silar Laboratories, Booth 2045
Siltech Corporation, Booth 1349
Sinobright Pharmaceutical Company Ltd, Booth 2403
Sinochem Lantian Co, Ltd, Booth 1523
SK Life Science, Inc, Booth 1506
SOCMA, Booth 2357
SOCMA Member Lounge, Booth 2457
Solid Form Solutions Ltd, Booth 1925
Solvay Fluorides LLC, Booth 2239
Solvias Inc, Booth 2211
Spectrum Chemical Mfg, Corp, Booth 1944
SSI Chusei, Inc, Booth 2346
SST Corporation, Booth 2231
Strem Chemicals Inc, Booth 1319
Sumitomo Chemical Europe S.A. / N.V., Booth 2413
Suven Life Sciences USA, Booth 2125
Suzhou Everfortune Imp.&Exp. Co, Ltd, Booth 1246b
Suzhou Highfine Biotech Co, Ltd, Booth 1208
Synasia Inc, Booth 1400
Syngene International, Booth 2050
SynQuest Laboratories, Inc, Booth 2159
SYNTHON Chemicals GmbH & Co KG, Booth 1922
T10 Chemicals, Booth 921D
Takasago International Corp, Booth 2148
Takasago International Corp, Booth MR33
TCG Lifesciences, Booth 2147
TCI America, Booth 1940
Tekno Scienze SRL, Booth 2412
The Chemical Company, Booth 2400
Thomson Reuters, Booth 1000
Tianjin Jingye Fine Chemicals Co, Ltd, Booth 2019
TM Chemicals LP, Booth 2256
Topharman Shanghai Co, Ltd, Booth 2145
Tosoh USA Inc, Booth 1625
TrustChem Co, Ltd, Booth 2139
Ubichem Pharma Services, Booth 2433
UBM Live, Booth 1709
Umicore AG & Co KG, Booth 1131
United Biochemicals, Booth 1954
Upscale Microwave Inc, Booth 1525
US EPA Green Chemistry Program, Booth 2423i
Valsynthese S.A, Booth 1501
VanDeMark Chemical, Inc, Booth 1321
Varsal Inc, Booth 1224
Veolia Environmental Services, Booth 2008
Vertellus Specialties Inc, Booth 1113
Virto/Elcan Industries, Booth 2453
Waterstone Pharmaceuticals Inc, Booth 1558
Weatherford, Booth 1358
Weihai NewEra Chemical Co, Ltd, Booth 2258
Western States Machine Corp., Booth 2345
WeylChem Corporation, Booth 1801
WIL Research, Booth 1513
Wilmington Pharma Tech Co, LLC, Booth 1702
Wockhardt Ltd, Booth 1125
WuXi AppTec Inc, Booth 2113
Xi’an Ruilian Modem Electronic Chemicals,
Booth 1006
Xiangfan Goto Chemical Co, Ltd, Booth 1126
Yangzhou Chemical Co ltd, Booth 1527
Yixing Qiancheng Bio-Engineering Co, Ltd, Booth 1122
Yizheng City East Chemical Co, Ltd, Booth 1112
Zach System S.P.A., Booth 1701
Zepol, Booth 1030
Zhangjiagang Feihang Industry Co, Ltd, Booth 2027
Zhejiang Apeloa Kangyu Pharmaceutical Co,
Booth 1915
Zhejiang Charioteer Pharmaceutical Co, L, Booth 2132
Zhejiang Jianfeng Haizhou Pharmaceutical,
Booth 2319
Zhejiang Medicines & Health Products I/E, Booth 2005
Zhejiang Taizhou Qingquan Medical & Chem,
Booth 2013
Zhejiang Tianyu Pharmaceutical Co, Ltd, Booth 2118
Zhejiang Tongfeng Pharma & Chem. Co, Ltd,
Booth 2025
Zhejiang Yongning Pharmaceutical Co, Ltd ,
Booth 1246a
Zhongdan Group, Booth 1549
Zhongdan Group, Booth MR4
14
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
CML Invests to Support Late-Phase and Commercial API Demand
mid-sized pharma companies who have compounds at, or
past, phase 2 clinical trials.
Many contract API suppliers who have a strong base
of assets to handle programs from phase 2 through
launch have seen remarkable growth in their portfolio
of API projects. And Cambridge Major Labs is no
exception. In July of 2012, CML embarked on a major
expansion of its large scale API plant in Wisconsin.
Scheduled to be complete in April, the expansion will
increase CML’s large scale capacity by nearly 30 percent,
enabling more capacity for the large number of phase 2
and phase 3 APIs in CML’s funnel. Having a supplier that
can meet the growing volume needs as APIs progress
to commercialization is key to a successful new product
launch; no technical transfer is required, and the API
supply is effectively de-risked.
Now with all this talk about late phase pipelines, we
need not overlook our friends in the preclinical space;
quite obviously without them, we wouldn’t be here. Over
the next few years, once the clinical pipelines run their
course, our pre-clinical friends will be back in full swing,
With sluggishness in the pre-clinical pipelines the past few years, most of our
and those of us who have assets to bring the next wave of APIs to IND will be
friends in the pre-clinical toxicology space have been through numerous quarterly
enjoying feast rather than famine. However, the API suppliers who have the assets
reports articulating the woes of the past quarter, and the optimism that the future
and personnel to accomplish all of the above will be in the best position to take
(hopefully) brings. What has been largely overlooked until recently is the strength
these forward—all the way to commercial with no tech transfers.
of the late phase pipelines. Funding has been reasonably robust to emerging and
Visit Cambridge Major Labs at Booth 2225.
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
15
PCI Launches Four Proprietary APIs,
Current Generic APIs Headed Toward Commercialization
PCI Synthesis, a 14-year-old phar-
Newburyport plant for later stage
maceutical manufacturer of new
clinical development.
chemical entities (NCEs), generic active
The commitment to developing
pharmaceutical ingredients (APIs), and
other specialty chemical products, has
new equipment.
The contract research organization
the routes of synthesis, optimizing
molecules, performing process
(CRO) and contract manufacturing
improvements, and scaling up,”
generic APIs is part of a long-standing
organization (CMO) is currently involved
said Ed Price, president of PCI.
effort by the company to invest in
in the development of four additional
“The investment in developing our
launched four new proprietary APIs that
and develop capacity for aggressive
late stage products that were included
capacity has been paying off for our
were initiated during 2012, increasing
growth. Last year, PCI completed the
in MM&M’s Pipeline 2011 list of top
clients and PCI Synthesis itself by
to 13 the number of exclusive generic
build out of its Devens, MA-based
launch prospects.
enabling us to expand our experience
APIs in its pipeline.
facility, growing capacity by 30 percent,
PCI, which provides dozens of
emerging pharma clients with
access to expertise for the
development and manufacturing of
complex small molecules to be used as
NCEs, expects the current set of
generic APIs to be commercialized over
the next three to four years. The
company also has committed to
developing another three to four new
products in 2013.
In 2012, the company continued
the clinical development of more
than half dozen different NCEs for
many of its Boston-area partners.
Many of these products are now in
the process of being scaled up in its
From Organic page 9
What can subscribers look
forward to seeing in OPRD
in 2013?
We will be introducing new
features such as Virtual Issues on
particular topics and we are considering
introducing new sections on Best
Practices and tricks of the Trade. We
welcome suggestions from readers
on how we can further enhance the
journal and our Editorial Advisory Board
meets this week in Anaheim to help
drive the innovation process.
Organic Process Research &
Development, an American
Chemical Society (ACS) publication,
covers the broad field of process
chemistry encompassing aspects of
organic chemistry, catalysis,
analytical chemistry, and chemical
engineering, with special focus on the
development and optimisation of
chemical reactions and processes and
their transfer to a larger scale, via large
laboratory and pilot plant operations,
for manufacture.
“We have a smart team that
bringing on new hires, implementing
understands the complex dynamics of
new cGMP systems, and purchasing
small molecules, from developing
and expertise.
Visit PCI Synthesis at Booth
1059.
16
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Kilo Lab Centrifuges Suited
for Small Scale Processing
Rousselet Robatel
kilo lab centrifuges
Vast amounts of resources go into drug development, including time, money, and
are suited for R &
personnel. Choosing the right contract research organization to help with scale-up
D, and small-scale
projects can be tricky, considering that everyone wants to maximize value for their
processing. This
research dollars.
centrifuge can be
There are several important factors that go into CRO selection. Cost is an issue
equipped with three
for everyone, but other factors to consider are: experience level; facilities; and
different- sized
convenience.
interchangeable
PharmaCore, based in High Point, NC, is an example of a CRO with an
rotors for processing
experienced staff. Three of its five technicians have more than 20 years of
multiple batch sizes.
experience in pharmaceutical process development facilities like Amylin, Parke-
Basket filtration
Davis, and Pfizer. The three project managers each have 15-20 years of experience
and solid / liquid
in pharmaceutical API scale-up environments. Overseeing the GMP manufacturing
sedimentation
process is Brian Swierenga, VP and a chemical engineer with more than 25 years of
are possible.
experience in pharmaceutical research and manufacturing. Similarly, the majority of
Hard- or soft-sided
PharmaCore’s organic chemists hold doctorates in chemistry.
containment systems can be installed for use with potent compounds. Rental
equipment is available for on-site testing.
Cart-mounted installation allows for easy portability and this centrifuge
can be installed in a fume hood. These centrifuges can be equipped with
explosion-proof electrical controls. Multiple materials of construction are
available, such as 316L stainless, Hastelloy C, and other alloys.
Visit Rousselet Robatel at Booth 1352.
PharmaCore: Choosing
the Right CRO for
Scale-up Projects
Commissioning an experienced CRO to work on projects is a crucial step in
ensuring success in drug development programs.
PharmaCore has completed work on more than 55 large-scale projects of which
more than 30 of were conducted in a GMP environment.
PharmaCore’s GMP pilot plant has eight GMP suites in a 35,000-sq.-ft-facility
equipped for both custom organic synthesis and scale-up. The company is designed
to take a project from the beginning stages of drug discovery through Phase II or III.
Visit PharmaCore at Booth 1508.
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Five Minutes With…
Joseph A.
Chiaroni
17
the USA and a less competitive Chinese economy will create growth opportunities,
provided increasingly restrictive regulations do not stifle investment in the U.S.
President
And what do you believe are the most creative solutions?
Nova Molecular
Technologies
responsive to customers globally will create a significant competitive advantage.
Bringing lower cost and new products and services to markets faster and being
Continuous improvement coupled with close partnerships in R&D or production will
allow risk sharing and sustainable profitability improvement.
What are your major concerns
within your market over the next
two years?
Over the next two years, the pace of
economic recovery in the world is a concern,
What should be the common goals within the industry and/or
marketplace?
The chemical industry must strive to help create an economic environment that
fosters growth, capital investment and job creation in the U.S.: low energy costs,
compounded by continued slow growth or recession in Europe and major slowdown
less and more flexible regulations, capital investment incentives and a level playing
in China. This situation might accelerate consolidation or divestitures among chemical
field among global players.
companies, limiting growth opportunities for smaller players and postponing or
cancelling new programs requiring capital or research and development.
Among the challenges the industry faces, which do you think are
the most pressing?
The main challenge facing the specialty chemical industry is to adapt to
slower growth and consolidation among key players. To do so, companies need
What is one relevant question (and your answer) that you believe
no one is addressing adequately?
As a global industry player, we need a system of regulations and standards
which does not penalize smaller industry players with global ambitions by erecting
financial, technological or other “invisible” barriers to market penetration, especially
with innovative products or services.
to craft strategies linking cost competitive innovation with impeccable execution
in production and customer service, to secure sustainable advantage as a valued
Nova Molecular Technologies is a grassroots custom and specialty chemical
partner to their customers. At the same time, by utilizing the lower energy costs in
manufacturer located in Pasadena, TX.
18
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Five Minutes With…
Tony Uberoi
We should develop a streamlined approach to regulatory oversight. Whenever
Vice President, Sales
regulations are considered, peer reviewed science and rational overall assessment
Gabriel Performance
Products
must also be a key part of the process, with a strong emphasis on cost/benefit
analysis. Let’s develop practical regulations, which do not handcuff our business
leaders with unnecessary bureaucracy bogging down the system. This will release
resources that can be redeployed to help grow the industry.
What are your major concerns within
your market over the next two years?
We continue to see two factors that are
exerting strong influence on our business. The
What should be the common goals within the industry and/or
marketplace?
The industry must continue to operate with a focus on outstanding environmental,
first is the increasing level of regulation that
health, safety and security performance (EHS&S). Beyond that we must work to improve
we face, much of which seems quite arbitrary.
the image of the chemical industry with key stakeholders such as regulators, politicians
These new regulations increase our costs while drawing resources away from other
and the general public. The chemical industry makes a significant impact on the well-
developments, hampering our ability to grow. The second factor is the increasing
being of mankind (via improved water, food, energy, human health, goods, safety and
difficulty of identifying and hiring technical people to support our growth targets.
comfort). This effort should be a multipronged approach, with industry associations
working in tandem with a grassroots approach driven by individuals within the industry.
Among the challenges the industry faces, which do you think are
the most pressing?
The most pressing challenge is how to maintain a strong economic recovery with
Too often, we hear “it’s a Chemical” uttered with disdain and disgust and we let it go.
One-on-one discussion can be effective at educating the public one person at a time. We
must ensure our society understands the key role that chemistry plays in their lives.
sustainable job growth in the U.S., while managing the ever increasing and rapidly expanding regulations that many times are not rational or based on sound science. These
regulations are often counter-productive toward realizing the economic and societal
benefits the chemical industry brings to the well-being of mankind throughout the world.
What is one relevant question (and your answer) that you believe
no one is addressing adequately?
Q: The U.S. seems to forget that manufacturing was a key driver to our improved
standard of living though out much of the 20th century. As we move toward a service-
And what do you believe are the most creative solutions?
based economy, what will fuel our continued improvement in our standard of living?
q
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
p A: We believe we must return to our
From AFC page 11
manufacturing roots. Increases in labor
to increase public awareness of both
Manufacturers & Affiliates) is proactively
public school level to help promote
productivity over the past seven decades
the necessity and benefits
addressing major issues and
interest in chemistry related
allowed for the improvement of wages
of a viable U.S.-based Fine & Specialty
opportunities facing our industry
curriculums, promotion of green
and general business conditions. We are
Chemical industrial base. A lack of
beginning with a very proactive
chemistries across our industry
proud that we have been in business for
appreciation of the contribution of our
involvement with our U.S.
through an effective “ChemStewards”
more than 50 years, and have been able
industry can lead to uninformed
Congressional leadership via a
program.
to add jobs over the past seven years,
support of bad law and similar
series of focused congressional
expanding our workforce by 40 percent.
limitations based on limited
member interactions with professional
AFC is a U.S. based custom fine
With strong support from our owners,
understanding and reactionary
staff and a series of SOCMA
chemical manufacturer of Active
Edgewater Capital Partners, we continue
responses to important events within
member/ congress member events.
Pharmaceutical Ingredients &
to invest in manufacturing for growth.
our industry, communities and
The organization is also leading
Registered Intermediates with facilities
In a more favorable business climate that
neighbors.
technical & science education
in California and Texas.
rate of growth could be even higher.
Let’s make the R&D tax credit permanent
and look for ways to hasten the return
of chemical manufacturing previously
outsourced.
Gabriel Performance Products
specializes in chemical contract
manufacturing and provides numerous
epoxy curing and specialty lubricants.
Umicore
Registers Its API
Plant with FDA
Umicore recently registered its API
Plant with FDA and will register the
drug master files (DMF) for each of its
three APIs Cisplatinum, Carboplatinum,
and Oxali-platinum with FDA in the first
quarter of this year.
After having received CEPs for
these products and several European
audits for its Argentina-based plant,
this is another step towards Umicore
becoming the a one-stop shop for its
clients’ global API needs.
Registering the DMFs with the
FDA will trigger an FDA audit, which is
expected towards the end of the year.
In light of recent bottlenecks in supply
chain on the Platinum APIs, Umicore’s
strategy to keep safety stocks of all
products at its cGMP plant is allowing
optimized lead-times when supplying
products to its clients around the world.
Besides meeting global quality
standards for all regions, Umicore can
customize CoAs according to its clients’
needs. This allows globally acting clients
to benefit from a flexible product
qualification for different markets.
Visit Umicore at Booth 1131.
SOCMA (Society of Chemical
19
initiatives at the university and
20
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Novasep Invests $4 Million
to Boost HPAPI Manufacturing Capabilities
chemistry at -60°C in hastelloy reactors, as well as large-scale HPLC
chromatography and drying in confined areas to manufacture ADC
toxins at commercial scale.
The pharmaceutical industry increasingly demands targeted and
potent drugs, such as antibody-drug conjugates (ADCs), to improve
efficacy and reduce side effects especially for anti-cancer therapies. Of
the 39 new molecular entities (NME) approved by the FDA in 2012, one
third were cancer treatments.
In this context, the new investment strengthens Novasep’s position
on the global HPAPI and ADC market. With its unique combination
of synthesis and purification technology in confined area—and more
than 25 years of experience in the manufacture of HPAPIs—Novasep
is a partner of choice for the production of highly potent toxins often
required for ADCs.
The experience of the FDA-inspected site in Le Mans has been
recognized by SafeBridge with its certification since 2009.
“Manufacturing for the life science sectors is facing a series
of challenges. Drug candidates have become more specific and
personalized, while the economic climate demands more cost-effective
Novasep, a supplier of manufacturing solutions to the life sciences industries,
and safer solutions,” said Patrick Glaser, CEO of Novasep. “Novasep’s development
is investing $4 million to expand its highly potent API (HPAPI) manufacturing
strategy has enabled us to anticipate these changes in the market, and today we are
capabilities at its site in Le Mans, France.
increasing our capability to meet future market demand. This new investment is the
In the expanded cGMP facility, Novasep will perform the synthesis, purification,
and isolation of highly potent compounds with an OEL (Occupational Exposure
Limit) lower than 0.03 µg.m-3.8h-1 at kg- scale. The investment features cryogenic
result of our continued commitment in HPAPI and our long-term collaboration with
our customers.”
Visit Novasep at Booth 1939.
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
BioVectra:
Strengthened
Commitment,
Continuity as
API Supplier
As a longstanding participant in the
industry, BioVectra invites InformEX
attendees to meet with its management
team: Ron Keefe, CEO; Dale Zajicek,
president; and Heather Delage, director
of sales and marketing.
BioVectra remains committed to
maintaining its position as a specialized
contract manufacturer and development
partner. The acquisition by Questcor Pharmaceuticals ensures continuity of the BioVectra business plan, including continued
execution on a number of client-partnered
capital expansion projects. InformEX 2013
is the first major industry event since the
acquisition where the company can present the progress it has made, and demonstrate its performance as a technologybased, cGMP API manufacturer.
The company’s recent accomplishments include: the start-up and commissioning of an $18 million dedicated
API manufacturing facility, a multi-ton
synthetic capacity addition to address
launch-preparation and commercial
quantities of drug substance for a major
patient population therapeutic; the ongoing $5-million expansion and qualification
of a dedicated manufacturing wing for a
client approaching late-stage development
and filing of its product; and the completion of a second fermentation wing to
produce commercial and clinical quantities
of fermentation API products, extending
its capabilities and experience to handle
small-molecule, high potency fermentation systems.
BioVectra soon will announce
additional expansion plans as it
continues to invest to meet the needs
of customers.
“We remain committed to
continued growth and extension
of our expertise, technologies, and
manufacturing capacity,” said BioVectra
president Dale Zajicek. “Questcor has
consistently stated its interest in the
acquisition as to ensure its own supply
chain security, and diversify its business.
Visit BioVectra at Booth 2156.
21
22
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
Educational Foundation Helps Chemical
Companies Develop Future Workforce
The You Be The Chemist Challenge, CEF’s academic competition for grades 5-8, brings
together members of the chemical industry, students, educators, and community members
in celebration of science. Almost 20,000 students from around the country will participate
in the program this year, scheduled for June 24. The students pictured competed in the
2012 National Challenge held in Philadelphia.
T
CEF partnered with The Franklin Institute in Philadelphia to conduct a You Be The Chemist
Essential Elements professional development workshop with educators who participated in
its challenge program. These workshops use CEF’s Activity Guide lessons to walk educators
through ways to better engage students through inquiry-based learning and are sponsored
by members of the chemical industry nationwide.
he Chemical Educational Foundation (CEF) is a national non-profit
collaboration is vital to improving the state of science education in the U.S., the
organization that works to enhance science education opportunities for the
future of the industry, and society as a whole.
nation’s youth. It collaborates with members of the chemical industry to
implement outreach initiatives in their community.
CEF’s You Be The Chemist educational series includes the Activity Guides,
“CEF programs serve as an avenue by which member companies of organizations
such as the Society of Chemical Manufacturers & Affiliates (SOCMA) and the National
Association of Chemical Distributors (NACD) show their commitment to engaging
Challenge, and Essential Elements professional development programs. These
students and educators in science education,” stated CEF executive director John Rice.
interactive, community-based programs for students in grades K-8 are in use by
“The result of these interactions is the development of a new generation of citizens
hundreds of chemical companies, educational entities, and community organizations
that genuinely understands and appreciates the benefits of chemistry and the chemical
across the country.
industry. This positively impacts the development of a workforce for the future and the
These groups work together to encourage the study of science, technology,
engineering, and math subjects and augment the related resources available to
industry’s right to do business,” he added.
Founded in 1989 and headquartered in Arlington, VA, the Chemical Educational
educators and students. The chemical industry and the many volunteers that
Foundation works closely with industry to enhance science education opportunities
give of their time and effort in support of the programs recognize that this group
for our youth.
From Rx-360 page 1
volunteers to get “a ton of work done” on the Chino project and complete the job at the
has helped to build or repair more than
600,000 houses, serving more than 3
Ontario site, according to Martin Van Trieste, Amgen’s senior VP of quality.
“This project has been a success for everybody,” Sternquist said. “We were very
million people worldwide. The Pomona
excited by the enthusiasm of the group, and we were happy to see people make
office, which opened in 1982, has
donations as individuals and as a group. They were very much into the spirit of what
completed 44 houses.
we do. We just prayed that it wouldn’t rain.”
Karen Seiberlich of the Amgen
Van Trieste considers Habitat for Humanity a worthwhile philanthropic organization
supplier quality management team
because “it helps people who haven’t had nurturing, good fortune and breaks to keep
contacted Pomona Valley Habitat in
their families together and give their children a chance to advance in life.”
October on behalf of Rx-360, which
Another benefit, he said, is allowing people in Rx-360 to get to know each other
recruited more than 40 volunteers for the projects. They worked on a six-building condo
by working on such a good project. “We already have plans to do this again next
complex in Chino and a single-family home in Ontario, according to Habitat’s Morgan
year when Informex is in Miami,” he said.
Sternquist.
Hours priming, painting, caulking, sanding, among other tasks enabled the
For more information about Rx-360, its activities and an update on the Habitat
for Humanity project, visit Booth 2152.
INFORMEX Show Daily | Wednesday February 20 2013 | Anaheim Convention Center Anaheim California
23
The
Art
of
the
Party
Sets the Tone for a Week of Networking
Nothing like a grand party to get an InformexUSA conference off to a great start. Networking and more networking was on the menu Monday evening at the
C&EN-sponsored reception. Still, no one could help but also concentrate on the fine dining options: from decadent mashed potato servings in martini glasses to
savory short ribs smothered mac n’ cheese plates. Mingling folks kept the party highly charged with ambitious plans for this InformexUSA 2013 iteration.
Top row, left to right: Balraj Kalirai, of Robinson Brothers and
Michael Holding of Contract Chemical; SOCMA’s Erica Green
and Austin Alderice sandwich Mike Velotta of McGean;
Shoufu Lu and Yunfei Rao of Shanghai Biopharma; Bottom
row, left to right: Oakwood’s Cheri Butler, Greg Butler, and
Lin Lin; and Cambrex’s George Rothermel, John Michnick,
Rick Offerman, and Josh Van Kley
A d v e r t i s e r s
I n d e x
AMPAC Fine Chemicals, Booth 2257, www.ampacfinechemicals.com. . . . . . 2
Ash Stevens, Inc., Booth 1552, www.ashstevens.com. . . . . . . . . . . . . . Cover
BioVectra Inc., Booth 2156, www.biovectra.com. . . . . . . . . . . . . . . . . . . . . . 8
Cambridge Major Laboratories, Inc., Booth 2225, www.c-mlabs.com. . . . 19
C&EN, Booth 2447, cen.acs.org. . . . . . . . . . . . . . . . . . . . . . . . . . . . 17, 18, 20
Chemtura Corp., Booth1548, www.chemtura.com . . . . . . . . . . . . . . . . . . . 8
DFI Pharma, Booth 1545, www.dfipharma.com. . . . . . . . . . . . . . . . . . . . . . . 9
Evonik, Booth 1238, www.evonik.com/pharma. . . . . . . . . . . . . . . . . . . . . . 24
Fabbrica Italiana Sintetici SpA, Booth 2049, fisvi.com. . . . . . . . . . . . . . . . 11
Federal Equipment Co., Booth 2030, www.fedequip.com . . . . . . . . . . . . . 17
Helsinn Advanced Synthesis S.A., Booth 1809, www.helsinn.com. . . . . . . 10
J-Star, Booth 1343, www.jstar-research.com . . . . . . . . . . . . . . . . . . . . . . . . 14
LIST USA Inc., Booth 2419, www.list.us. . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Nova Molecular Technologies, Inc., Booth 1442, www.novamolecular.com. . 9
Oakwood Products, Inc., Booth 1109, www.oakwoodchemical.com . . . . . 23
Organic Technologies, Booth 1247, www.organictech.com. . . . . . . . . . . . 14
PCI Synthesis.com, Booth 1059, www.pcisynthesis.com . . . . . . . . . . . . . . . 16
PharmaCore, Inc., Booth 1303, www.pharmacore.com. . . . . . . . . . . . . . . . 15
Ricerca Biosciences, Booth 2060, www.ricerca.com . . . . . . . . . . . . . . . . . . 21
Siegfried USA, Inc., Booth 1101, www.siegfried.ch. . . . . . . . . . . . . . . . . . . 16
Umicore AG & Co. KG, Booth 1131, www.umicore.com. . . . . . . . . . . . . . . . 7
Zach Stystem S.P.A., Booth1701, www.zachsystem.com. . . . . . . . . . . . . . . 18