RAPPORT ANNUEL 2015 LES ANNEXES RÉ VO LU TION(S) sommaire 03 équipes de recherche de Gustave Roussy 05 Publications à impact factor supérieur à 20 (228 publications) 26 Publications à impact factor compris entre 10 et 20 (73 publications) 33 Publications à impact factor compris entre 5 et 10 (458 publications) 3 / équipes de recherche DE GUSTAVE ROUSSY • TLS Polymérases et Cancer Responsable : Patricia Kannouche CNRS UMR 8200 - Stabilité génétique et oncogenèse, Patricia Kannouche • Organisation nucléaire et modèles pathologiques Responsables : Yegor Vassetzky / Marc Lipinski CNRS UMR 8126 - Signalisation, Noyaux et Innovations en oncologie, Joëlle Wiels / Marc Lipinski • Les voies de signalisation FANC/BRCA et Cancers Responsable : Filippo ROSSELLI CNRS UMR 8200 - Stabilité génétique et oncogenèse, Patricia Kannouche • Oncogenèses et résistance à l’apoptose dans les lymphomes B Responsable : Joëlle Wiels CNRS UMR 8126 - Signalisation, Noyaux et Innovations en oncologie, Joëlle Wiels / Marc Lipinski • Recombination / Réparation et Cancer Responsable : Bernard Lopez CNRS UMR 8200 - Stabilité génétique et oncogenèse, Patricia Kannouche • Intégrité du génome et microscopie moléculaire Responsable : Éric Le Cam CNRS UMR 8126 - Signalisation, Noyaux et Innovations en oncologie, Joëlle Wiels / Marc Lipinski • Réparation de l’ADN Responsable : Murat Saparbaev CNRS UMR 8200 - Stabilité génétique et oncogenèse, Patricia Kannouche • Microenvironnement tumoral, exosomes et microARN dans les tumeurs solides Responsable : Pierre Busson CNRS UMR 8126 - Signalisation, Noyaux et Innovations en oncologie, Joëlle Wiels / Marc Lipinski • Division cellulaire et stabilité génomique Responsable : Olivier Gavet CNRS UMR 8200 - Stabilité génétique et oncogenèse, Patricia Kannouche • Vectorologie des Acides Nucléiques et des Médicaments Anticancéreux Responsables : Lluis Mir / K. Benihoud CNRS UMR 8203 - Laboratoire de Vectorologie et Thérapeutiques anticancéreuses, Lluis Mir et K. Benihoud • Nouvelles Thérapies Anticancéreuses Responsable : Liliane Massade CNRS UMR 8203 - Laboratoire de Vectorologie et Thérapeutiques anticancéreuses, Lluis Mir et K. Benihoud • Physiologie et Pathologie Moléculaires des Rétrovirus Endogènes et Infectieux Responsable : Thierry Heidmann CNRS UMR 9196 • Trafic intracellulaire, complexes macromoléculaires et cancer Responsable : Svetlana Dokudovskaya CNRS UMR 8126 - Signalisation, Noyaux et Innovations en oncologie, Joëlle Wiels / Marc Lipinski • Imagerie multimodale en cancérologie Responsable : Nathalie Lassau CNRS UMR 8081 - Imagerie par Résonance Magnétique Médicale et Multi-Modalités (IR4M), Luc Darrasse et Nathalie Lassau • Stades précoces de la transformation hématopoïétique Responsables : Olivier Bernard / Virginie Penardlacronique Inserm UMR 1170 - Hématopoïèse normale et pathologique, Olivier Bernard • Des cellules souches hématopoïétiques aux mégacoryocytes Responsable : Hana Raslova Inserm UMR 1170 - Hématopoïèse normale et pathologique, Olivier Bernard • Génétique et modélisation des tumeurs malignes pédiatriques Responsable : Thomas Mercher Inserm UMR 1170 - Hématopoïèse normale et pathologique, Olivier Bernard 4 • Des cellules souches hématopoïétiques aux monocytes Responsables : Eric Solary / Françoise Porteu Inserm UMR 1170 - Hématopoïèse normale et pathologique, Olivier Bernard • Biomarqueurs prédictifs et nouvelles stratégies thérapeutiques en oncologie Responsable : Fabrice André Inserm UMR 981 • Stress réplicatif, instabilité génomique et mitose Responsable : Valéria Naim - Équipe ERC Starting CNRS UMR 8200 - Stabilité génétique et oncogenèse, Patricia Kannouche • Immunologie des tumeurs et immunothérapie Responsable : Laurence Zitvogel Inserm UMR 1015 • Méthodologie et épidémiologie clinique pour l’oncologie moléculaire (équipe 2) Responsable : Stephan Michiels Centre de recherche en épidémiologie et en santé des populations, Bruno Falissard • Radiothérapie moléculaire Responsables : Eric Deutsch et Jean-Luc Perfettini Inserm UMR 1030 • Immunologie intégrative des tumeurs Responsable : Fathia Mami-Chouaib / Salem CHOUAIB Inserm UMR 1186 • Réparation des cassures double brin et intégrité du génome Responsable : Gérard Mazon - Equipe ATIP-AVENIR CNRS UMR 8200 - Stabilité génétique et oncogenèse, Patricia Kannouche • Invasion collective et morphogenèse épithéliale Responsable : Fanny Jaulin - Equipe ATIP-AVENIR CNRS UMR 8126 - Signalisation, Noyaux et Innovation en oncologie, Joëlle Wiels • Endocytose, cytosquelette et migration cellulaire Responsable : Guillaume Montagnac - Equipe ATIPAVENIR Inserm UMR 1170 - Hématopoïèse normale et pathologique, Olivier Bernard • Cellules souches hématopoïétiques normales et cancéreuses : contrôles génétique et épigénétique Responsable : Camille Lobry - Equipe ATIP-AVENIR Inserm UMR 1170 - Hématopoïèse normale pathologique, Olivier Bernard • Rôle de la traduction d’ARNm dans la présentation antigénique Responsable : Sébastien Apcher - Equipe ATIP-AVENIR Inserm UMR 1015 - Immunologie des tumeurs et immunothérapie, Laurence Zitvogel et • Oncogenèse et progression tumorale du mélanome Responsable : Medhi Khaled - Equipe ATIP-AVENIR Inserm UMR 1186 - Immunologie intégrative des tumeurs, Fathia Mami-Chouaib • Epidémiologie des radiations, épidémiologie clinique des cancers et survie (équipe 3) Responsable : Florent de Vathaire Centre de recherche en épidémiologie et en santé des populations, Bruno Falissard • Mode de vie, génétique et santé : études intégratives et trans-générationnelles (équipe 9) Responsable Marie-Christine Boutron-Ruault Centre de recherche en épidémiologie et en santé des populations, Bruno Falissard • Management des organisations de santé Responsable : Etienne Minvielle EHESP - EA 7348 • Apoptose, cancer et immunité Responsable : Guido Kroemer Inserm / CNRS UMRS1138 Université Paris-Descartes Centre de Recherche des Cordeliers, Pascale Ferre / Guido Kroemer 5 / Publications internationales Gustave Roussy en 2015 À impact factor supérieur à 20 (228 publications) 1. Albigès L., Xie W., Chen Y.H., Boher J.M., Valenca L.B., Bernard B.D., Culine S., Habibian M., Carducci M.A., DiPaola R.S., Liu G., Pomerantz M., Nakabayashi M., Kantoff P.W., Fizazi K., Gravis G., and Sweeney C. Disease burden and outcome in metastatic hormone sensitive prostate cancer (mHSPC). [2015] Journal of Clinical Oncology (33) 15 suppl : 5052. Impact factor : 20,982 2. Albigès L., Fay A.P., Xie W., McDermott D.F., Heng D.Y.C., Dariane C., De Velasco G., Lester R.E., Escudier B., and Choueiri T.K. Efficacy of targeted therapies after PD1/PD-L1 inhibitors in metastatic clear cell renal cell carcinoma (mRCC): A multiinstitution retrospective cohort. [2015] Journal of Clinical Oncology (33) 7 suppl : 456. Impact factor : 20,982 3. Amela E., Bompas E., Le Cesne A., Tresch E., Italiano A., Piperno-Neumann S., Collard O., Vansteene D., Domont J., Saada E., Isambert N., Salas S., Chevreau C., Bertucci F., Delaine S.C., Blay J.Y., and Penel N. A phase II trial of sorafenib (SO) in advanced chordoma patients (pt). [2015] Journal of Clinical Oncology (33) 15 suppl : 10520. Impact factor : 20,982 4. André F., Deluche É., and Bonnefoi H. Bevacizumab: the phoenix of breast oncology? [2015] Lancet Oncology (16) 6 : 600-601. Impact factor : 26,509 5. Angevin E., Isambert N., Trillet-Lenoir V.N., You B., Alexandre J., Zalcman G., Viehl P., Farace F., Valleix F., Podoll T., Kuramochi Y., Miyashita I., Hosono O., Dang N.H., Ohnuma K., Yamada T., Kaneko Y., and Morimoto C. First-in-human phase I administration of YS110, a monoclonal antibody directed against the CD26 immunostimulatory molecule in advanced cancer patients. [2015] Journal of Clinical Oncology (33) 15 suppl : 2519. Impact factor : 20,982 6. Arkenau H.T., Gazzah A., Plummer R., Blagden S.P., Mak G., Soria J.C., Greystoke A., Rizzuto I., Rogan D., Mazumdar J., Laubscher K., Auger K.R., Swartz L.S., Mattern M.L., Nebot N., Singh R.P., Fleming R.A., and Yan L. A phase Ib dose-escalation study of GSK2256098 (FAKi) plus trametinib (MEKi) in patients with selected advanced solid tumors . [2015] Journal of Clinical Oncology (33) 15 suppl : 2593. Impact factor : 20,982 7. Barrios C.H., Anton A., Delaloge S., Montemurro F., Wuerstlein R., Robb S., Button P., and Ellis P.A. Safety of trastuzumab emtansine (T-DM1) in 373 patients 65 years or older with HER2-positive advanced breast cancer: A subgroup analysis of the Kamilla study. [2015] Journal of Clinical Oncology (33) 15 suppl : 603. Impact factor : 20,982 8. Bauer T.M., Shaw A.T., Solomon B., Besse B., James L.P., Clancy J.S., Mugundu G., Martini J.F., Abbattista A., and Felip E. Phase I/II study of PF-06463922, an ALK/ROS1 tyrosine kinase inhibitor, in patients with advanced non-small-cell lung cancer harboring specific molecular alterations. [2015] Journal of Clinical Oncology (33) 15 suppl : TPS2620. Impact factor : 20,982 9. Beer T.M., Armstrong A.J., Sternberg C.N., Higano C.S., Rathkopf D.E., Loriot Y., Saad F., Joshua A.M., De Bono J.S., Venner P.M., Carles J., Mainwaring P.N., Evans C.P., Parli T., Mansbach H.H., Bhattacharya S., Van Os S., Phung D., and Tombal B.F. Enzalutamide (ENZA) in men with chemotherapy-Naive metastatic castration-resistant prostate cancer (mCRPC): Final analysis of the phase 3 PREVAIL study. [2015] Journal of Clinical Oncology (33) 15 suppl : 5036. Impact factor : 20,982 10. Bellmunt J., Eigl B.J., Senkus-Konefka E., Loriot Y., Twardowski P., Castellano D.E., Blais N., Sridhar S.S., Sternberg C.N., Retz M., Blumenstein B.A., Jacobs C., Stewart P.S., and Petrylak D.P. First-line randomized phase II study of gemcitabine/cisplatin plus apatorsen or placebo in patients with advanced bladder cancer: The International Borealis-1 trial. [2015] Journal of Clinical Oncology (33) 15 suppl : 4503. Impact factor : 20,982 11. Ben Arush M.W., Minard-Colin V., Mosseri V., Desfachelles A.S., Bergeron C., Algret N., Fassola S., André N., Thebaud E., Corradini N., Bernier V., Martelli H., Ranchere-Vince D., and Orbach D. Does aggressive local treatment have an impact on survival in children with metastatic rhabdomyosarcoma? [2015] Journal of Clinical Oncology (33) 15 suppl : 10540 . Impact factor : 20,982 12. Besse B., Mazieres J., Ribassin-Majed L., Barlesi F., Bennouna J., Gervais R., Moreau L., Berard H., Debieuvre D., Molinier O., Moro-Sibilot D., Souquet P.J., Pignon J.P., Amour E., Celebic A., Morin F., Milleron B., Zalcman G., and Soria J.C. Pazopanib (P) or placebo in completely resected stage I NSCLC patients: Survival results of the phase II trial IFCT0703. [2015] Journal of Clinical Oncology (33) 15 suppl : 7510. Impact factor : 20,982 13. Blanchard P., Lee A., Marguet S., Leclercq J., Ng W.T., Ma J., Chan A.T., Huang P.Y., Benhamou E., Zhu G., Chua D.T., Chen Y., Mai H.Q., Kwong D.L., Cheah S.L., Moon J., Tung Y., Chi K.H., Fountzilas G., Zhang L., Hui E.P., Lu T.X., Bourhis J., and Pignon J.P. Chemotherapy and radiotherapy in 6 nasopharyngeal carcinoma: an update of the MACNPC meta-analysis. [2015] Lancet Oncology (16) 6 : 645-655. Impact factor : 26,509 14. Blay J.Y., Shen L., Kang Y.K., Rutkowski P., Qin S., Nosov D., Wan D., Trent J., Srimuninnimit V., Papai Z., Le Cesne A., Novick S., Taningco L., Mo S., Green S., Reichardt P., and Demetri G.D. Nilotinib versus imatinib as first-line therapy for patients with unresectable or metastatic gastrointestinal stromal tumours (ENESTg1): a randomised phase 3 trial . [2015] Lancet Oncology (16) 5 : 550-560. Impact factor : 26,509 15. Blay J.Y., Molimard M., Cropet C., Domont J., Toulmonde M., Bompas E., Cassier P.A., Ray-Coquard I.L., Rios M., Adenis A., Italiano A., Le Cesne A., Bouche O., Mir O., Duffaud F., Bertucci F., Isambert N., Belleville A., Gautier J., and Perol D. Final results of the multicenter randomized phase II PAZOGIST trial evaluating the efficacy of pazopanib (P) plus best supportive care (BSC) vs BSC alone in resistant unresectable metastatic and/or locally advanced gastrointestinal stromal tumors (GIST). [2015] Journal of Clinical Oncology (33) 15 suppl : 10506. Impact factor : 20,982 16. Boige V., Vincent M., Alexandre P., Stoehlmacher J., Tejpar S., Landolfi S., Le Malicot K., Greil R., Cuyle P.J., Yilmaz M.K., Faroux R., Matzdorff A., Salazar R., Sanches E., Mineur L., Lepage C., Taieb J., and Laurent-Puig P. DYPD genotyping to predict toxicity in patients with stage III colon cancer treated with 5-fluorouracil-based adjuvant chemotherapy in the PETACC-8 phase III trial. [2015] Journal of Clinical Oncology (33) 15 suppl : 3584. Impact factor : 20,982 17. Bonastre J., Marguet S., Lueza B., Michiels S., Delaloge S., and Saghatchian M. Reply to V.P. Retel et al, D. Gauchan et al, and C. Rahilly-Tierney et al(CostEffectiveness of the 70-Gene Signature Versus Adjuvant! Online and Systematic Chemotherapy for Risk Stratification of Patients With Node-Negative Breast Cancer: Does Accuracy Matter?). [2015] Journal of Clinical Oncology (33) 14 : 1629-1630. Impact factor : 20,982 18. Bonneterre J., Leary A., Campone M., Italiano A., Sablin M.P., Floquet A., Berton-Rigaud D., Lhomme C., Lesoin A., Chocteau-Bouju D., Fabbro M., Favier L., Gladieff L., Ray-Coquard I., Bexon A.S., Gilles E.M., Bisaha J., Zukiwski A., and Cottu P.H. Phase 2 clinical study of onapristone (ONA) in patients (pts) with uterine endometrioid adenocarcinoma (EC) expressing the activated progesterone receptor (APR(pos)). [2015] Journal of Clinical Oncology (33) 15 suppl : TPS5616. Impact factor : 20,982 19. Borget I., Martelli N., Vainchtock A., and Scotte F. Thromboembolic events in hospitalized cancer patients: Impact on stay duration and cost for four major cancer localizations. [2015] Journal of Clinical Oncology (33) 15 suppl : e17784. Impact factor : 20,982 20. Borget I., Bonastre J., Catargi B., Deandreis D., Zerdoud S., Rusu D., Bardet S., Leenhardt L., Bastie D., Schvartz C., Vera P., Morel O., Benisvy D., Bournaud C., Bonichon F., Kelly A., Toubert M.E., Leboulleux S., Journeau F., Benhamou E., and Schlumberger M. Quality of Life and CostEffectiveness Assessment of Radioiodine Ablation Strategies in Patients With Thyroid Cancer: Results From the Randomized Phase III ESTIMABL Trial. [2015] Journal of Clinical Oncology (33) 26 : 28852892. Impact factor : 20,982 21. Bougeard G., Renaux-Petel M., Flaman J.M., Charbonnier C., Fermey P., Belotti M., GauthierVillars M., Stoppa-Lyonnet D., Consolino E., Brugieres L., Caron O., Benusiglio P.R., Bressac-de Paillerets B., Bonadona V., Bonaiti-Pellie C., Tinat J., Baert-Desurmont S., and Frebourg T. Revisiting LiFraumeni Syndrome From TP53 Mutation Carriers. [2015] Journal of Clinical Oncology (33) 21 : 23452352. Impact factor : 20,982 22. Brock P.R., Maibach R., Childs M., Rajput K., Neuwelt E.A., Roebuck D., Sullivan M.J., Laithier V., Ronghe M., Lockwood L., dall’Igna P., Hiyama E., Brichard B., Skeen J., Mateos M.E., Fabre M., Rangaswami A.A., Capra M., Czauderna P., and Morland B. Antitumor efficacy in SIOPEL 6: A multi-centre open label randomised phase III trial of the efficacy of sodium thiosulphate (STS) in reducing ototoxicity in patients receiving cisplatin (Cis) monotherapy for standard risk hepatoblastoma (SR-HB). [2015] Journal of Clinical Oncology (33) 15 suppl : 10039. Impact factor : 20,982 23. Brose M.S., Schlumberger M., Tahara M., Wirth L.J., Robinson B., Elisei R., Newbold K., Kiyota N., Hoff A.O., Dutcus C., Song J., Sherman S.I., and Taylor M.H. Effect of age and lenvatinib treatment on overall survival for patients with I-131-refractory differentiated thyroid cancer in SELECT . [2015] Journal of Clinical Oncology (33) 15 suppl : 6048. Impact factor : 20,982 24. Brose M.S., Schlumberger M., Pena C., and Kappeler C. Sorafenib for patients with differentiated thyroid cancer. Reply. [2015] Lancet (385) 9964 : 228-229. Impact factor : 44,002 7 25. Cabagnols X., Cayuela J.M., and Vainchenker W. A CALR Mutation Preceding BCR-ABL1 in an Atypical Myeloproliferative Neoplasm. [2015] New England Journal of Medicine (372) 7 : 688-690. Impact factor : 59,558 26. Casali P.G., Le Cesne A., Poveda V.A., Kotasek D., Rutkowski P., Hohenberger P., Fumagalli E., Judson I.R., Italiano A., Gelderblom H., Adenis A., Hartmann J.T., Duffaud F., Goldstein D., Broto J.M., Gronchi A., Dei Tos A.P., Marreaud S., van der Graaf W.T., Zalcberg J.R., Litiere S., and Blay J.Y. Time to Definitive Failure to the First Tyrosine Kinase Inhibitor in Localized GI Stromal Tumors Treated With Imatinib As an Adjuvant: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Intergroup Randomized Trial in Collaboration With the Australasian GastroIntestinal Trials Group, UNICANCER, French Sarcoma Group, Italian Sarcoma Group, and Spanish Group for Research on Sarcomas. [20-122015] Journal of Clinical Oncology (33) 36 : 42764283. Impact factor : 20,982 27. Cassier P.A., Maki R.G., Wagner A.J., Bompas E., Gelderblom H., Kroep J.R., Thomas D.M., Italiano A., Seddon B.M., Van der Graaf W.T., Domont J., Blay J.Y., and Stacchiotti S. Imatinib mesylate (IM) activity in patients (pts) with locally advanced tenosynovial giant cell tumor/pigmented villonodular synovitis (TGCT). [2015] Journal of Clinical Oncology (33) 15 suppl : 10561. Impact factor : 20,982 28. Cavalcanti A., Robert C., Mateus C., Muret J., Lebbe C., Dutriaux C., Maubec E., Arnault J.P., Mansard S., Templier C., Lacour J.P., and Lanoy E. A randomized, open label, multicenter comparative phase II trial of ipilimumab after isolated limb perfusion (ILP), versus ILP alone in patients with in-transit metastases melanoma stage IIIB and IIIC. [2015] Journal of Clinical Oncology (33) 15 suppl : e20107. Impact factor : 20,982 29. Chan A., Delaloge S., Holmes F.A., Moy B., Iwata H., Harvey V.J., Robert N.J., Silovski T., Gokmen E., Von Minckwitz G., Ejlertsen B., Chia S.K., Mansi J., Barrios C.H., Gnant M., Wong A., Bryce R., Yao B., and Martin M. Neratinib after adjuvant chemotherapy and trastuzumab in HER2-positive early breast cancer: Primary analysis at 2 years of a phase 3, randomized, placebo-controlled trial (ExteNET). [2015] Journal of Clinical Oncology (33) 15 suppl : 508. Impact factor : 20,982 30. Chawla S.P., Schoffski P., Blay J.Y., Jones R.L., Gelderblom H., Attia S., Chmielowski B., Van Tine B.A., Trent J.C., Patel S., Wagner A.J., Viele J.K., Chugh R., Le Cesne A., Tinoco G., Sankhala K.K., Falcone J., Schweizer C., Weil S., and Maki R.G. A study of the safety and efficacy of the combination of gemcitabine and docetaxel with ontuxizumab (MORAb-004) in metastatic soft tissue sarcoma. [2015] Journal of Clinical Oncology (33) 15 suppl : TPS10577. Impact factor : 20,982 31. Choueiri T., Escudier B., Powles T., Mainwaring P., Rini B., I, Donskov F., Hammers H., Hutson T., Lee J.L., Peltola K., Roth B., Bjarnason G., Geczi L., Keam B., Maroto P., Heng D., Schmidinger M., Kantoff P., Borgman-Hagey A., Hessel C., Scheffold C., Schwab G., Tannir N., and Motzer R. Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma. [2015] New England Journal of Medicine (373) 19 : 1814-1823. Impact factor : 59,558 32. Choueiri T.K., Fishman M.N., Escudier B., McDermott D.F., Kluger H.M., Stadler W.M., Perez-Gracia J.L., McNeel D.G., Curti B.D., Harrison M.R., Plimack E.R., Appleman L.J., Fong L., Drake C.G., Young T.C., Chasalow S.D., Ross-Macdonald P., Simon J.S., Walker D., and Sznol M. Immunomodulatory activity of nivolumab in metastatic renal cell carcinoma (mRCC): Association of biomarkers with clinical outcomes. [2015] Journal of Clinical Oncology (33) 15 suppl : 4500. Impact factor : 20,982 33. Christopher A., Van Akkooi J., Siegel P., Schoengen A., Roewert-Huber J., Eggermont A.M., and Voit C.A. Long-term results of ultrasound (US)guided fine needle aspiration cytology (FNAC) in conjunction with sentinel node biopsy (SNB) to support step-wise approach in melanoma. [2015] Journal of Clinical Oncology (33) 15 suppl : 9067. Impact factor : 20,982 34. Colomba E., Albigès L., Le Teuff G., Eisen T., Stewart G., Fife K., Srinivasan A., Larkin J.M., Biondo A., Pickering L.M., Boyle H.J., Derosa L., Ralph C., Saldana C., Bernhard J.C., Barthelemy P., Recine F., and Escudier B. Metastatic chromophobe renal cell carcinoma treated with target therapies: A Renal Cross Chanel Group (RCCG) study. [2015] Journal of Clinical Oncology (33) 15 suppl : 4561. Impact factor : 20,982 35. Conteduca V., Caffo O., Fratino L., Lo Re G., Basso U., D’Angelo A., Donini M., Verderame F., Ratta R., Procopio G., Campadelli E., Massari F., Gasparro D., Ermacora P., Messina C., Giordano M., Alesini D., Maines F., and De Giorgi U. Visceral disease site to predict clinical outcome of metastatic castrationresistant prostate cancer (mCRPC) patients (pts) 8 treated with abiraterone acetate (AA): Results of the Italian compassionate use named patient program (NPP). [2015] Journal of Clinical Oncology (33) 15 suppl : e16045. Impact factor : 20,982 36. Cottu P.H., Italiano A., Varga A., Campone M., Leary A., Floquet A., Berton-Rigaud D., Sablin M.P., Lesoin A., Lhomme C., Bexon A.S., Gilles E.M., Jackson D., Bisaha J., Zukiwski A., Bosq J., and Bonneterre J. Onapristone (ONA) in progesterone receptor (PR)-expressing tumors: Efficacy and biomarker results of a dose-escalation phase 1 study. [2015] Journal of Clinical Oncology (33) 15 suppl : 5593. Impact factor : 20,982 37. Creutzberg C.L., de Boer S.M., Putter H., Powell M., Mileshkin L.R., Katsaros D., Bessette P., HaieMeder C., Ledermann J.A., Ottevanger P., Khaw P., Colombo A., Fyles A.W., Baron M.H., Nijman H.W., Nout R.A., Smit V.T., Verhoeven-Adema K., Kruitwagen R.F., and Kitchener H.C. Adjuvant chemotherapy and radiation therapy (RT) versus RT alone for women with high-risk endometrial cancer: Toxicity and quality-of-life results of the randomized PORTEC-3 trial . [2015] Journal of Clinical Oncology (33) 15 suppl : 5501. Impact factor : 20,982 38. Cunningham D., Zurlo A., Salazar R., Ducreux M., Waddell T.S., Stein A., Tournigand C., Scheithauer W., Sobrero A.F., Van Cutsem E., and Arnold D. IMPALA, a randomized phase III study in patients with metastatic colorectal carcinoma: Immunomodulatory maintenance therapy with TLR-9 agonist MGN1703. [2015] Journal of Clinical Oncology (33) 3 suppl : TPS791. Impact factor : 20,982 39. Daud A., Ribas A., Robert C., Hodi F., Wolchok J.D., Joshua A.M., Hwu W.J., Weber J.S., Gangadhar T.C., Joseph R.W., Dronca R.S., Patnaik A., Zarour H.M., Kefford R., Lindia J.A., Li X.N., Ebbinghaus S., Kang S.P., and Hamid O. Long-term efficacy of pembrolizumab (pembro; MK-3475) in a pooled analysis of 655 patients (pts) with advanced melanoma (MEL) enrolled in KEYNOTE-001. [2015] Journal of Clinical Oncology (33) 15 suppl : 9005. Impact factor : 20,982 40. De Santis M., Mulders P., Fizazi K., Gray T.E., McCoy C., Stubbs A., and Powles T. First prospective, open-label, phase 2 study of sipuleucel-T (sip-T) in European men with metastatic, castrationresistant prostate cancer (mCRPC). [2015] Journal of Clinical Oncology (33) 15 suppl : e16015. Impact factor : 20,982 41. Delaloge S., Caron O., and Feunteun J. Effect of PALB2 status on breast cancer precision medicine. [2015] Lancet Oncology (16) 6 : 598-600. Impact factor : 26,509 42. Denkert C., Von Minckwitz G., Brase J.C., Sinn B.V., Gade S., Kronenwett R., Pfitzner B.M., Salat C., Loi S., Schmitt W.D., Schem C., Fisch K., DarbEsfahani S., Mehta K., Sotiriou C., Wienert S., Klare P., André F., Klauschen F., Blohmer J.U., Krappmann K., Schmidt M., Tesch H., Kuemmel S., Sinn P., Jackisch C., Dietel M., Reimer T., Untch M., and Loibl S. Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy With or Without Carboplatin in Human Epidermal Growth Factor Receptor 2-Positive and Triple-Negative Primary Breast Cancers. [2015] Journal of Clinical Oncology (33) 9 : 983-991. Impact factor : 20,982 43. Doucet L.S., Derosa L., Albigès L., Massard C., Loriot Y., Fizazi K., and Escudier B.J. Medical therapy for renal cell cancer with pancreatic metastases: Experience of the Gustave Roussy Institute. [2015] Journal of Clinical Oncology (33) 7 suppl : 503. Impact factor : 20,982 44. Duffaud F., Meeus P., Bertucci F., Delhorme J.B., Stoeckle E., Isambert N., Bompas E., Gagniere J., Bouche O., Toulmonde M., Salas S., Blay J.Y., and Bonvalot S. Selective indications of surgery in esophageal gastrointestinal stromal tumors: A retrospective study of the French Sarcoma Group (FSG). [2015] Journal of Clinical Oncology (33) 15 suppl : 10534. Impact factor : 20,982 45. Durand J.P., Hebuterne X., Raynard B., Saint Guily J.L., and Goldwasser F. Prevalence of malnutrition in PS 0-1 cancer patients: Results of the NutriCancer2 one-day national survey in 2,197 cancer patients. [2015] Journal of Clinical Oncology (33) 15 suppl : 1587. Impact factor : 20,982 46. Eggermont A.M., Chiarion-Sileni V., Grob J.J., Dummer R., Wolchok J.D., Schmidt H., Hamid O., Robert C., Ascierto P.A., Richards J.M., Lebbe C., Ferraresi V., Smylie M., Weber J.S., Maio M., Konto C., Hoos A., de Pril V., Gurunath R.K., de Schaetzen G., Suciu S., and Testori A. 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Dumortier J., Dharancy S., Cannesson A., Lassailly G., Rolland B., Pruvot F.R., Boillot O., Faure S., Guillaud O., Rigole-Donnadieu H., Herrero A., Scoazec J.Y., Mathurin P., and Pageaux G.P. Recurrent Alcoholic Cirrhosis In Severe Alcoholic Relapse After Liver Transplantation: A Frequent and Serious Complication. [2015] American Journal of Gastroenterology (110) 8: 1160-1166, quiz 1167. Impact factor: 10,383 23. Fasanelli F., Baglietto L., Ponzi E., Guida F., Campanella G., Johansson M., Grankvist K., Johansson M., Assumma M.B., Naccarati A., Chadeau-Hyam M., Ala U., Faltus C., Kaaks R., Risch A., De Stavola B., Hodge A., Giles G.G., Southey M.C., Relton C.L., Haycock P.C., Lund E., Polidoro S., Sandanger T.M., Severi G., and Vineis P. Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts. [2015] Nature Communications (6): 10192. Impact factor: 11,329 24. Fizazi K., Abrahamsson P.A., Ahlgren G., Bellmunt J., Castellano D., Culine S., de Wit R., Gillessen S., Gschwend J.E., Hamdy F., James N., McDermott R., Miller K., Wiegel T., Wirth M., and Tombal B. Achievements and Perspectives in Prostate Cancer Phase 3 Trials from Genitourinary Research Groups in Europe: Introducing the Prostate Cancer Consortium in Europe. [2015] European Urology (67) 5: 904-912. Impact factor: 14,976 28 25. Fizazi K., Massard C., Smith M., Rader M., Brown J., Milecki P., Shore N., Oudard S., Karsh L., Carducci M., Damiao R., Wang H., Ying W., and Goessl C. Bonerelated Parameters are the Main Prognostic Factors for Overall Survival in Men with Bone Metastases from Castration-resistant Prostate Cancer. [2015] European Urology (68) 1: 42-50. Impact factor: 14,976 26. Fontes Jardim D.L., Schwaederle M., Wei C., Lee J.J., Hong D.S., Eggermont A.M., Schilsky R.L., Mendelsohn J., Lazar V., and Kurzrock R. Impact of a Biomarker-Based Strategy on Oncology Drug Development: A Meta-analysis of Clinical Trials Leading to FDA Approval. [2015] Journal of the National Cancer Institute (107) 11: djv253. Impact factor: 11,370 27. Galluzzi L., Pietrocola F., and Kroemer G. Molecular Regulation of Circadian Rhythms by Polyamines. [2015] Cell Metabolism (22) 5: 757-758. Impact factor: 17,303 28. Garrouste-Org, Perrin M., Soufir L., Vesin A., Blot F., Maxime V., Beuret P., Troche G., Klouche K., Argaud L., Azoulay E., and Timsit J.F. The Iatroref study: medical errors are associated with symptoms of depression in ICU staff but not burnout or safety culture. [2015] Intensive Care Medicine (41) 2: 273284. Impact factor: 10,125 29. Gartrell B.A., Coleman R., Efstathiou E., Fizazi K., Logothetis C.J., Smith M.R., Sonpavde G., Sartor O., and Saad F. Metastatic Prostate Cancer and the Bone: Significance and Therapeutic Options. [2015] European Urology (68) 5: 850-858. Impact factor: 14,976 30. Golan T., Messer A.R., Amitai-Lange A., Melamed Z., Ohana R., Bell R.E., Kapitansky O., Lerman G., Greenberger S., Khaled M., Amar N., Albrengues J., Gaggioli C., Gonen P., Tabach Y., Sprinzak D., Shalom-Feuerstein R., and Levy C. Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF. [2015] Molecular Cell (59) 4: 664-676. Impact factor: 13,958 31. Gravis G., Boher J.M., Fizazi K., Joly F., Priou F., Marino P., Latorzeff I., Delva R., Krakowski I., Laguerre B., Walz J., Rolland F., Theodore C., Deplanque G., Ferrero J.M., Pouessel D., Mourey L., Beuzeboc P., Zanetta S., Habibian M., Berdah J.F., Dauba J., Baciuchka M., Platini C., Linassier C., Labourey J.L., Machiels J.P., El Kouri C., Ravaud A., Suc E., Eymard J.C., Hasbini A., Bousquet G., Soulie M., and Oudard S. 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Impact of Bone-targeted Therapies in Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer Patients Treated with Abiraterone Acetate: Post Hoc Analysis of Study COU-AA-302. [2015] European Urology (68) 4: 570-577. Impact factor: 14,976 61. 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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types . [2015] Journal of the National Cancer Institute (107) 12: djv27. Impact factor: 11,370 62. Savona M.R., Malcovati L., Komrokji R., Tiu R.V., Mughal T.I., Orazi A., Kiladjian J.J., Padron E., Solary E., Tibes R., Itzykson R., Cazzola M., Mesa R., Maciejewski J., Fenaux P., Garcia-Manero G., Gerds A., Sanz G., Niemeyer C.M., Cervantes F., Germing U., Cross N.C., and List A.F. An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults. [2015] Blood (125) 12: 18571865. Impact factor: 11,841 63. Schmid C., Labopin M., Socie G., Daguindau E., Volin L., Huynh A., Bourhis J.H., Milpied N., Cornelissen J., Chevallier P., Maertens J., Jindra P., Blaise D., Lenhoff S., Ifrah N., Baron F., Ciceri F., Gorin C., Savani B., Giebel S., Polge E., Esteve J., Nagler A., and Mohty M. Outcome of patients with distinct molecular genotypes and cytogenetically normal AML after allogeneic transplantation. [22-10-2015] Blood (126) 17: 2062-2069 . Impact factor: 11,841 64. Selimoglu-Buet D., Wagner-Ballon O., Saada V., Bardet V., Itzykson R., Bencheikh L., Morabito M., Met E., Debord C., Benayoun E., Nloga A.M., Fenaux P., Braun T., Willekens C., Quesnel B., Ades L., Fontenay M., Rameau P., Droin N., Koscielny S., and Solary E. Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia. [2015] Blood (125) 23: 3618-3626. Impact factor: 11,841 65. Semeraro M., Rusakiewicz S., Minard-Colin V., Delahaye N.F., Enot D., Vely F., Marabelle A., Papoular B., Piperoglou C., Ponzoni M., Perri P., Tchirkov A., Matta J., Lapierre V., Shekarian T., Valsesia-Wittmann S., Commo F., Prada N., PoirierColame V., Bressac B., Cotteret S., Brugieres L., Farace F., Chaput N., Kroemer G., Valteau-Couanet D., and Zitvogel L. Clinical impact of the NKp30/B7H6 axis in high-risk neuroblastoma patients. [2015] Science Translational Medicine (7) 283: 283ra55. Impact factor: 16,264 66. Sica V., Galluzzi L., Pedro J.M.B.-S., Izzo V., Maiuri M.C., and Kroemer G. Organelle-Specific Initiation of Autophagy. [2015] Molecular Cell (59) 4: 522-539. Impact factor: 13,958 67. Sicre de Fontbrune F., Moignet A., Beaupain B., Suarez F., Galicier L., Socié G., Varet B., Coppo P., Michel M., Pautas C., Oksenhendler E., Lengline E., Terriou L., Moreau P., Chantepie S., Casadevall N., Michot J.M., Gardembas M., Michallet M., Croisille L., Audrain M., Bellanné-Chantelot C., Donadieu J., and Lamy T. Severe chronic primary neutropenia in adults: report on a series 108 patients. [2015] Blood (126) 14: 1643-1650 . Impact factor: 11,841 68. Somers J., Wilson L.A., Kilday J.P., Horvilleur E., Cannell I.G., Poeyry T.A., Cobbold L.C., Kondrashov A., Knight J.R., Puget S., Grill J., Grundy R.G., Bushell M., and Willis A.E. A common polymorphism in the 5 ‘ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy. [2015] Genes & Development (29) 18: 1891-1896. Impact factor: 10,042 69. Thompson B.J., Bhansali R., Diebold L., Cook D.E., Stolzenburg L., Casagrande A.S., Besson T., Leblond B., Desire L., Malinge S., and Crispino J.D. DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3 . [1-62015] Journal of Experimental Medicine (212) 6: 953-970. Impact factor: 11,240 70. Vainchenker W. and Plo I. TET2 loss, a rescue of JAK2V617F HSCs. [2015] Blood (125) 2: 212-213. Impact factor: 11,841 71. Vera-Badillo F.E., Templeton A.J., Duran I., Ocana A., de Gouveia P., Aneja P., Knox J.J., Tannock I.F., Escudier B., and Amir E. Systemic Therapy for Non-clear Cell Renal Cell Carcinomas: A Systematic Review and Meta-analysis . [2015] European Urology (67) 4: 740-749. Impact factor: 14,976 32 72. Zitvogel L. and Kroemer G. Subversion of anticancer immunosurveillance by radiotherapy. [2015] Nature Immunology (16) 10: 1005-1007. Impact factor: 19,381 73. Zitvogel L., Galluzzi L., Viaud S., Vetizou M., Daillere R., Merad M., and Kroemer G. Cancer and the gut microbiota: An unexpected link . [2015] Science Translational Medicine (7) 271: 271ps1. Impact factor: 16,264 33 / Publications internationales (tous types) Gustave Roussy en 2015 A impact factor compris entre 5 et 10 (458 publications) 1. Aapro M., Dielenseger P., Dranitsaris G., Jordan K., Molassiotis A., Roeland E., Schwartzberg L., and Warr D. Patient-related factors in determining the emetic risk potential for patients undergoing chemotherapy: An evaluation of predictive models for the development of a risk assessment tool . [2015] European Journal of Cancer (51) suppl 3: S234-S234. Impact factor: 6,163 2. Adam J., Boros A., Lacas B., Lacroix L., Pignon J., Caramella C., Planchard D., Levy A., Besse B., and Le Pechoux C. Prognostic value of PDL1 expression in stage III Non-Small Cell Lung Cancer (NSCLC) treated by chemo-radiotherapy (CRT) . [2015] European Journal of Cancer (51) Suppl 3: S604. Impact factor: 6,163 3. Albigès L., Fay A.P., Xie W., Krajewski K., McDermott D.F., Heng D.Y.C., Dariane C., DeVelasco G., Lester R., Escudier B., and Choueiri T.K. Efficacy of targeted therapies after PD-1/PD-L1 blockade in metastatic renal cell carcinoma. [2015] European Journal of Cancer (51) 17: 2580-2586. Impact factor: 6,163 4. Albigès L., Kube U., Eymard J.C., Schmidinger M., Bamias A., Kelkouli N., Mraz B., Florini S., Guderian G., Cattaneo A., and Bergmann L. Everolimus for patients with metastatic renal cell carcinoma refractory to anti-VEGF therapy: Results of a pooled analysis of non-interventional studies . [2015] European Journal of Cancer (51) 16: 2368-2374. Impact factor: 6,163 5. Aleksandrova K., Bamia C., Drogan D., Lagiou P., Trichopoulou A., Jenab M., Fedirko V., Romieu I., Bueno-de-Mesquita H.B., Pischon T., Tsilidis K., Overvad K., Tjønneland A., Bouton-Ruault M.C., Dossus L., Racine A., Kaaks R., Kuhn T., Tsironis C., Papatesta E.M., Saitakis G., Palli D., Panico S., Grioni S., Tumino R., Vineis P., Peeters P.H., Weiderpass E., Lukic M., Braaten T., Quiros J.R., Lujan-Barroso L., Sanchez M.J., Chilarque M.D., Ardanas E., Dorronsoro M., Nilsson L.M., Sund M., Wallstrom P., Ohlsson B., Bradbury K.E., Khaw K.T., Wareham N., Stepien M., Duarte-Salles T., Assi N., Murphy N., Gunter M.J., Riboli E., Boeing H., and Trichopoulos D. The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition. [2015] American Journal of Clinical Nutrition (102) 6: 1498-1508. Impact factor: 6,703 6. Alentorn A., Dehais C., Ducray F., Carpentier C., Mokhtari K., Figarella-Branger D., Chinot O., CohenMoyal E., Ramirez C., Loiseau H., Elouahdani-Hamdi S., Beauchesne P., Langlois O., Desenclos C., Guillamo J.S., Dam-Hieu P., Ghiringhelli F., Colin P., Godard J., Parker F., Dhermain F., Carpentier A.F., Frenel J.S., Menei P., Bauchet L., Faillot T., Fesneau M., Fontaine D., Motuo-Fotso M.J., Vauleon E., Gaultier C., Le Guerinel C., Gueye E.M., Noel G., Desse N., Durando X., Barrascout E., Wager M., Ricard D., Carpiuc I., Delattre J.Y., and Idbaih A. Allelic loss of 9p21 .3 is a prognostic factor in 1p/19q codeleted anaplastic gliomas. [2015] Neurology (85) 15: 1325-1331. Impact factor: 8,166 7. Allard M.A., Cunha A.S., Gayet B., Adam R., Goere D., Bachellier P., Azoulay D., Ayav A., Navarro F., and Pessaux P. Early and Long-term Oncological Outcomes After Laparoscopic Resection for Colorectal Liver Metastases: A Propensity Scorebased Analysis. [2015] Annals of surgery (262) 5: 794-802. Impact factor: 8,569 8. Ameziane-El-Hassani R., Talbot M., Dos Santos M.C.d.S., Al Ghuzlan A., Hartl D., Bidart J.M., De Deken X., Miot F., Diallo I., De Vathaire F., Schlumberger M., and Dupuy C. NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation. [2015] Proceedings of the National Academy of Sciences of the United States of America (112) 16: 5051-5056. Impact factor: 9,423 9. Angileri F., Roy V., Morrow G., Scoazec J.Y., Gadot N., Orejuela D., and Tanguay R.M. Molecular changes associated with chronic liver damage and neoplastic lesions in a murine model of hereditary tyrosinemia type 1 . [2015] Biochimica et Biophysica Acta Molecular Basis of Disease (1852) 12: 2603-2617. Impact factor: 5,158 10. Angoulvant A., Stern J.B., Wittnebel S., Bourhis J.H., Gachot B., Vittecoq D., and Wyplosz B. Dyspnea and Fever in an Allogeneic Stem Cell Recipient. [2015] Clinical Infectious Diseases (60) 1: 100, 157-158. Impact factor: 8,736 11. Antoun S., Bayar A., Ileana E., Laplanche A., Fizazi K., Di Palma M., Escudier B., Albigès L., Massard C., and Loriot Y. High subcutaneous adipose tissue predicts the prognosis in metastatic castration-resistant prostate cancer patients in post chemotherapy setting. [2015] European Journal of Cancer (51) 17: 2570-2577. Impact factor: 6,163 12. Aranda F., Buqué A., Bloy N., Castoldi F., Eggermont A., Cremer I., Fridman W.H., Fucikova J., Galon J., Spisek R., Tartour E., Zitvogel L., Kroemer G., and Galluzzi L. Trial Watch: Adoptive cell transfer for oncological indications. [2015] Oncoimmunology (4) 11: e1046673. Impact factor: 7,644 34 13. Arca M., Fardet L., Galicier L., Riviere S., Marzac C., Aumont C., Lambotte O., and Coppo P. Prognostic factors of early death in a cohort of 162 adult haemophagocytic syndrome: impact of triggering disease and early treatment with etoposide . [2015] British Journal of Haematology (168) 1: 63-68. Impact factor: 5,401 14. Arnold D., Scheithauer W., Zurlo A., Salazar R., Ducreux M., Waddell T., Stein A., Tournigand C., Sobrero A., Van Cutsem E., and Cunningham D. Immunomodulatory switch maintenance therapy to improve overall survival in metastatic colorectal carcinoma: The phase 3 IMPALA study. [2015] Annals of Oncology (26) suppl 4: iv90-iv91. Impact factor: 9,269 15. Attard G., Gurney H., Loriot Y., Borre M., Andresen C., Wu K., Taylor C., Amelsberg A., and Taplin M. Preliminary findings from PLATO: A two-period, phase 4, randomized, doubleblind, placebo-controlled study of continued enzalutamide treatment beyond progression in men with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC). [2015] European Journal of Cancer (51) suppl 3: S487. Impact factor: 6,163 16. Attard G., de Bono J.S., Logothetis C.J., Fizazi K., Mukherjee S.D., Joshuas A.M., Schrijvers D., van den Eertwegh A.J., Li W., Molina A., Griffin T.W., Kheoh T., Ricci D.S., Zelinsky K., Rathkopf D.E., Scher H.I., and Ryan C.J. Improvements in Radiographic Progression-Free Survival Stratified by ERG Gene Status in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Abiraterone Acetate. [2015] Clinical Cancer Research (21) 7: 1621-1627. Impact factor: 8,738 17. Aumont C., Driss F., Lazure T., Picard V., Creidy R., De Botton S., Saada V., Lambotte O., Bilhou-Nabera C., Tertian G., and Michot J.M. Myelodysplastic syndrome with clonal cytogenetic abnormalities followed by fatal erythroid leukemia after 14 years of exposure to hydroxyurea for sickle cell anemia. [2015] American Journal of Hematology (90) 7: E131-E132. Impact factor: 5 18. Autebert J., Coudert B., Champ J., Saias L., Guneri E.T., Lebofsky R., Bidard F.C., Pierga J.Y., Farace F., Descroix S., Malaquin L., and Viovy J.L. High purity microfluidic sorting and analysis of circulating tumor cells: towards routine mutation detection. [2015] Lab on A Chip (15) 9: 2090-2101. Impact factor: 5,586 19. Auzolle C., Dubreuil O., Pozet A., Coriat R., Dhooge M., Ducreux M., Mons M., Brieau B., Baumgaertner I., Gornet J., Lievre A., Locher C., Mary F., Bonnetain F., and Landi B. Efficacy and toxicity of secondline chemotherapy in patients with advanced oesophageal squamous cell carcinoma progressing after a first line of 5-fluorouracil and platinumbased therapy: An AGEO retrospective multicentric study. [2015] European Journal of Cancer (51) suppl 3: S438-S438. Impact factor: 6,163 20. Ayadi M., Bouygues A., Ouaret D., Ferrand N., Chouaib S., Thiery J.P., Muchardt C., Sabbah M., and Larsen A.K. Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors. [2015] Oncotarget (6) 21: 18518-18533. Impact factor: 5,008 21. Babitzki G., Hidalgo M., Massard C., Martinez Garcia M., Le Tourneau C., Boni V., Albanell Mestres J., Taus Garcia A., Alt M., Sablin M., Gerber P., Krieter O., Lahr A., Palme S., Rossomanno S., Harring S.V., Wild N., Zajac M., and Lechner K. Biomarkers related to Vanucizumab single agent therapy in serial plasma, tumor tissue and skin wound-healing biopsies of patients with advanced solid tumors . [2015] European Journal of Cancer (51) suppl 3: S88-S89. Impact factor: 6,163 22. Bach A.S., Derocq D., Laurent-Matha V., Montcourrier P., Sebti S., Orsetti B., Theillet C., Gongora C., Pattingre S., Ibing E., Roger P., Linares L.K., Reinheckel T., Meurice G., Kaiser F.J., Gespach C., and LiaudetCoopman E. Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells. [2015] Oncotarget (6) 29: 2808428103. Impact factor: 5,008 23. Badirou I., Pan J., Souquere S., Legrand C., Pierron G., Wang A., Eckly A., Roy A., Gachet C., Vainchenker W., Chang Y., and Leon C. Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet release . [2015] Journal of Thrombosis and Haemostasis (13) 5: 851-859. Impact factor: 5,565 24. Bahleda R., Hollebecque A., Varga A., Gazzah A., Massard C., Deutsch E., Amellal N., Farace F., OuldKaci M., Roux F., Marzin K., and Soria J.C. Phase I study of afatinib combined with nintedanib in patients with advanced solid tumours. [2015] British Journal of Cancer (113) 10: 1413-1420. Impact factor: 5,569 35 25. Baldeck N., Janel-Bintz R., Wagner J., Tissier A., Fuchs R.P., Burkovics P., Haracska L., Despras E., Bichara M., Chatton B., and Cordonnier A.M. FF483484 motif of human Pol eta mediates its interaction with the POLD2 subunit of Pol delta and contributes to DNA damage tolerance . [2015] Nucleic acids research (43) 4: 2116-2125. Impact factor: 9,202 26. Bamia C., Lagiou P., Jenab M., Trichopoulou A., Fedirko V., Aleksandrova K., Pischon T., Overvad K., Olsen A., Tjønneland A., Boutron-Ruault M.C., Fagherazzi G., Racine A., Kuhn T., Boeing H., Floegel A., Benetou V., Palli D., Grioni S., Panico S., Tumino R., Vineis P., Bueno-de-Mesquita H.B., Dik V.K., BhooPathy N., Uiterwaal C.S.P.M., Weiderpass E., Lund E., Quirós J.R., Zamora-Ros R., Molina-Montes E., Chirlaque M.D., Ardanaz E., Dorronsoro M., Lindkvist B., Wallström P., Nilsson L.M., Sund M., Khaw K.T., Wareham N., Bradbury K.E., Travis R.C., Ferrari P., Duarte-Salles T., Stepien M., Gunter M., Murphy N., Riboli E., and Trichopoulos D. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study . [2015] International Journal of Cancer (136) 8: 1899-1908. Impact factor: 5,531 27. Bamia C., Lagiou P., Jenab M., Aleksandrova K., Fedirko V., Trichopoulos D., Overvad K., Tjønneland A., Olsen A., Clavel-Chapelon F., Boutron-Ruault M.C., Kvaskoff M., Katzke V.A., Kühn T., Boeing H., Nöthlings U., Palli D., Sieri S., Panico S., Tumino R., Naccarati A., Bueno-de-Mesquita H.B., Peeters P.H.M., Weiderpass E., Skeie G., Quirós J.R., Agudo A., Chirlaque M.D., Sanchez M.J., Ardanaz E., Dorronsoro M., Ericson U., Nilsson L.M., Wennberg M., Khaw K.T., Wareham N., Key T.J., Travis R.C., Ferrari P., Stepien M., Duarte-Salles T., Norat T., Murphy N., Riboli E., and Trichopoulou A. Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study. [2015] British Journal of Cancer (112) 7: 1273-1282. Impact factor: 5,569 28. Bang Y., Doi T., De Braud F., Piha-Paul S., Hollebecque A., Razak A., Lin C., Ott P., He A., Yuan S., Koshiji M., Lam B., and Aggarwal R. Safety and efficacy of pembrolizumab (MK-3475) in patients (pts) with advanced biliary tract cancer: Interim results of KEYNOTE-028. [2015] European Journal of Cancer (51) suppl 3: S112-S112. Impact factor: 6,163 29. Bardet V., Wagner-Ballon O., Guy J., Morvan C., Debord C., Trimoreau F., Benayoun E., Chapuis N., Freynet N., Rossi C., Mathis S., Gourin M.P., Toma A., Béné M.C., Feuillard J., and Guérin E. Multicentric study underlining the interest of adding CD5, CD7 and CD56 expression assessment to the flow cytometric Ogata score in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms. [2015] Haematologica (100) 4: 472-478. Impact factor: 6,671 30. Barrdahl M., Canzian F., Lindström S., Shui I., Black A., Hoover R.N., Ziegler R.G., Buring J.E., Chanock S.J., Diver W., Gapstur S.M., Gaudet M.M., Giles G.G., Haiman C., Henderson B.E., Hankinson S., Hunter D.J., Joshi A.D., Kraft P., Lee I.M., Le Marchand L., Milne R.L., Southey M.C., Willett W., Gunter M., Panico S., Sund M., Weiderpass E., Sánchez M.-J., Overvad K., Dossus L., Peeters P.H., Khaw K.T., Trichopoulos D., Kaaks R., and Campa D. Association of breast cancer risk loci with breast cancer survival. [2015] International Journal of Cancer (137) 12: 2837-2845. Impact factor: 5,531 31. Bastide N.M., Chenni F., Audebert M., Santarelli R.L., Tache S., Naud N., Baradat M., Jouanin I., Surya R., Hobbs D.A., Kuhnle G.G., Raymond-Letron I., Gueraud F., Corpet D.E., and Pierre F.H. A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake. [2015] Cancer Research (75) 5: 870-879. Impact factor: 8,556 32. Beelen R., Hoek G., Raaschou-Nielsen O., Stafoggia M., Andersen Z.J., Weinmayr G., Hoffmann B., Wolf K., Samoli E., Fischer P.H., Nieuwenhuijsen M.J., Xun W.W., Katsouyanni K., Dimakopoulou K., Marcon A., Vartiainen E., Lanki T., Yli-Tuomi T., Oftedal B., Schwarze P.E., Nafstad P., De Faire U., Pedersen N.L., Otstenson C.G., Fratiglioni L., Penell J., Korek M., Pershagen G., Eriksen K.T., Overvad K., Sorensen M., Eeftens M., Peeters P.H., Meliefste K., Wang M., Bueno-de-Mesquita H., Sugiri D., Kramer U., Heinrich J., de Hoogh K., Key T., Peters A., Hampel R., Concin H., Nagel G., Jaensch A., Ineichen A., Tsai M.Y., Schaffner E., Probst-Hensch N.M., Schindler C., Ragettli M.S., Vilier A., Clavel-Chapelon F., Declercq C., Ricceri F., Sacerdote C., Galassi C., Migliore E., Ranzi A., Cesaroni G., Badaloni C., Forastiere F., Katsoulis M., Trichopoulou A., Keuken M., Jedynska A., Kooter I.M., Kukkonen J., Sokhi R.S., Vineis P., and Brunekreef B. Natural-Cause Mortality and Long-Term Exposure to Particle Components: An Analysis of 19 European Cohorts within the MultiCenter ESCAPE Project . [2015] Environmental Health Perspectives (123) 6: 525-533. Impact factor: 8,443 36 33. Bellera C., Penel N., Ouali M., Bonvalot S., Casali P., Nielsen O., Delannes M., Litiere S., Bonnetain F., Dabakuyo T., Benjamin R., Blay J., Bui B., Collin F., Delaney T., Duffaud F., Filleron T., Fiore M., Gelderblom H., George S., Grimer R., Grosclaude P., Gronchi A., Haas R., Hohenberger P., Issels R., Italiano A., Jooste V., Krarup-Hansen A., Le Pechoux C., Mussi C., Oberlin O., Patel S., Piperno-Neumann S., Raut C., Ray-coquard I., Rutkowski P., Schuetze S., Sleijfer S., Stoeckle E., Van Glabbeke M., Woll P., Gourgou-Bourgade S., and Mathoulin-Pelissier S. Guidelines for time-to-event end point definitions in sarcomas and gastrointestinal stromal tumors (GIST) trials: results of the DATECAN initiative (Definition for the Assessment of Time-to-event Endpoints in CANcer trials) . [2015] Annals of Oncology (26) 5: 865-872. Impact factor: 9,269 34. Bellini A., Bernard V., Leroy Q., Frio T.R., Pierron G., Combaret V., Lapouble E., Clement N., Rubie H., Thebaud E., Chastagner P., Defachelles A.S., Bergeron C., Buchbinder N., Taque S., Auvrignon A., Valteau-Couanet D., Michon J., Janoueix-Lerosey I., Delattre O., and Schleiermacher G. Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis. [2015] Clinical Cancer Research (21) 21: 4913-4921. Impact factor: 8,738 35. Ben Arush M., Minard-Colin V., Mosseri V., Defachelles A., Bergeron C., Algret N., Fasola S., André N., Thebaud E., Corradini N., Bernier V., Martelli H., Ranchere D., and Orbach D. Does aggressive local treatment have an impact on survival in children with metastatic rhabdomyosarcoma? [2015] European Journal of Cancer (51) 2: 193-201. Impact factor: 6,163 36. Benhamou Y., Boelle P.Y., Baudin B., Ederhy S., Gras J., Galicier L., Azoulay E., Provot F., Maury E., Pene F., Mira J., Wynckel A., Presne C., Poullin P., Halimi J., Delmas Y., Kanouni T., Seguin A., Mousson C., Servais A., Bordessoule D., Perez P., Hamidou M., Cohen A., Veyradier A., and Coppo P. Cardiac troponin-I on diagnosis predicts early death and refractoriness in acquired thrombotic thrombocytopenic purpura . Experience of the French Thrombotic Microangiopathies Reference Center. [2015] Journal of Thrombosis and Haemostasis (13) 2: 293-302. Impact factor: 5,565 37. Benhamou Y., Baudel J.L., Wynckel A., Galicier L., Azoulay E., Provor F., Pene F., Mira J.P., Presne C., Poullin P., Halimi J.M., Riviere E., Kanouni T., Seguin A., Mousson C., Servais A., Bordessoule D., Perez P., Hamidou M., Chauveau D., Veyradier A., and Coppo P. Are platelet transfusions harmful in acquired thrombotic thrombocytopenic purpura at the acute phase? experience of the French thrombotic microangiopathies reference center. [2015] American Journal of Hematology (90) 6: E127-E129. Impact factor: 5 38. Benusiglio P.R., Couve S., Gilbert-Dussardier B., Deveaux S., Le Jeune H., Da Costa M., Fromont G., Memeteau F., Yacoub M., Coupier I., Leroux D., Mejean A., Escudier B., Giraud S., Gimenez-Roqueplo A.P., Blondel C., Frouin E., Teh B.T., Ferlicot S., Bressacde Paillerets B., Richard S., and Gad S. A germline mutation in PBRM1 predisposes to renal cell carcinoma. [2015] Journal of Medical Genetics (52) 6: 426-430. Impact factor: 5,650 39. Benusiglio P.R., Colas C., Rouleau E., Uhrhammer N., Romero P., Remenieras A., Moretta J., Wang Q., De Pauw A., Buecher B., Stoppa-Lyonnet D., MouretFourme E., Nogues C., Di Maria M., Tlemsani C., Warcoin M., Grandjouan S., Malka D., Caron O., and Blayau M. Hereditary diffuse gastric cancer syndrome: improved performances of the 2015 testing criteria for the identification of probands with a CDH1 germline mutation. [2015] Journal of Medical Genetics (52) 8: 563-565. Impact factor: 5,650 40. Benyoucef A., Calvo J., Renou L., Arcangeli M.L., van den Heuvel A., Amsellem S., Mehrpour M., Larghero J., Soler E., Naguibneva I., and Pflumio F. The SCL/ TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells . [2015] Stem Cells (33) 7: 2268-2279. Impact factor: 5,902 41. Bergthold G., Bandopadhayay P., Hoshida Y., Ramkissoon S., Ramkissoon L., Rich B., Maire C.L., Paolella B.R., Schumacher S.E., Tabak B., FerrerLuna R., Ozek M., Sav A., Santagata S., Wen P.Y., Goumnerova L.C., Ligon A.H., Stiles C., Segal R., Golub T., Grill J., Ligon K.L., Chan J.A., Kieran M.W., and Beroukhim R. Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype. [2015] Neuro-Oncology (17) 11: 1486-1496. Impact factor: 7,371 42. Bernardini M., Thevenet H., Berthold C., Fischer A., Petitguillaume A., Desbree A., Smadja C., Weinmann P., and Ghazzar N. Reconstruction, volumetry and dosimetry optimisation for 99mTc-SPECT and 90Y-PET images: towards reliable DVH for SIRT treatments . [2015] European Journal of Nuclear Medicine and Molecular Imaging (42) suppl 1: S139-S139. Impact factor: 5,537 37 43. Bertrand J.R., Pioche-Durieu C., Ayala J., Petit T., Girard H.A., Malvy C.P., Le Cam E., Treussart F., and Arnault J.C. Plasma hydrogenated cationic detonation nanodiamonds efficiently deliver to human cells in culture functional siRNA targeting the Ewing sarcoma junction oncogene . [2015] Biomaterials (45): 93-98. Impact factor: 8,387 44. Besevic J., Gunter M.J., Fortner R.T., Tsilidis K.K., Weiderpass E., Charlotte Onland-Moret N., Dossus L., Tjønneland A., Hansen L., Overvad K., Mesrine S., Baglietto L., Clavel-Chapelon F., Kaaks R., Aleksandrova K., Boeing H., Trichopoulou A., Lagiou P., Bamia C., Masala G., Agnoli C., Tumino R., Ricceri F., Panico S., Bueno-de-Mesquita H.a., Peeters P.H., Jareid M., Ramon Quiros J., Duell E.J., Sanchez M.J., Larranaga N., Chirlaque M.D., Barricarte A., Dias J.A., Sonestedt E., Idahl A., Lundin E., Wareham N.J., Khaw K.T., Travis R.C., Rinaldi S., Romieu I., Riboli E., and Merritt M.A. Reproductive factors and epithelial ovarian cancer survival in the EPIC cohort study. [1-12-2015] British Journal of Cancer (113) 11: 1622-1631. Impact factor: 5,569 45. Besse B., Johnson M., Jaenne P., Garassino M., Eberhardt W., Peters S., Toh C., Kurata T., Li Z., Kowanetz M., Mocci S., Sandler A., and Rizvi N. Phase II, single-arm trial (BIRCH) of atezolizumab as firstline or subsequent therapy for locally advanced or metastatic PD-L1-selected non-small cell lung cancer (NSCLC). [2015] European Journal of Cancer (51) suppl 3: S717-S718. Impact factor: 6,163 46. Besse B., Girard N., Gazzah A., Hierro C., Felip E., De Braud F., Camboni G., Dubois F., Leger C., Legrand F., Robert R., Therasse P., and Soria J. Activity and safety profile of lucitanib in patients with advanced thymic epithelial tumours. [2015] European Journal of Cancer (51) suppl 3: S607-S607. Impact factor: 6,163 47. Besse B., Le Moulec S., Mazieres J., Senellart H., Barlesi F., Chouaid C., Dansin E., Berard H., Falchero L., Gervais R., Robinet G., Ruppert A.M., Schott R., Lena H., Clement-Duchene C., Quantin X., Souquet P.J., Tredaniel J., Moro-Sibilot D., Perol M., Madroszyk A.C., and Soria J.C. Bevacizumab in Patients with Nonsquamous Non-Small Cell Lung Cancer and Asymptomatic, Untreated Brain Metastases (BRAIN): A Nonrandomized, Phase II Study. [2015] Clinical Cancer Research (21) 8: 18961903. Impact factor: 8,738 48. Beuschlein F., Weigel J., Saeger W., Kroiss M., Wild V., Daffara F., Libe R., Ardito A., Al Ghuzlan A., Quinkler M., Osswald A., Ronchi C.L., de Krijger R., Feelders R.A., Waldmann J., Willenberg H.S., Deutschbein T., Stell A., Reincke M., Papotti M., Baudin E., Tissier F., Haak H.R., Loli P., Terzolo M., Allolio B., Mueller H.H., and Fassnacht M. Major Prognostic Role of Ki67 in Localized Adrenocortical Carcinoma After Complete Resection . [2015] Journal of Clinical Endocrinology & Metabolism (100) 3: 841-849. Impact factor: 5,531 49. Beuselinck B., Jean-Baptiste J., Couchy G., Job S., De Reynies A., Wolter P., Theodore C., Gravis G., Rousseau B., Albigès L., Joniau S., Verkarre V., Lerut E., Patard J., Schoffski P., Mejean A., Elaidi R., Oudard S., and Zucman-Rossi J. RANK/OPG ratio of expression in primary clear-cell renal cell carcinoma is associated with bone metastasis and prognosis in patients treated with anti-VEGFR-TKIs. [2015] British Journal of Cancer (113) 9: 1313-1322. Impact factor: 5,569 50. Bezu L., Gomes-de-Silva L.C., Dewitte H., Breckpot K., Fucikova J., Spisek R., Galluzzi L., Kepp O., and Kroemer G. Combinatorial strategies for the induction of immunogenic cell death. [2015] Frontiers in Immunology (6): 187. Impact factor: 5,695 51. 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Bidard F.C., Stoppa-Lyonnet D., Nogues C., Caron O., Delaloge S., Dugast C., Lasset C., Berger F., Asselain B., Lantz O., Stern M.H., and Pierga J.Y. TP53 mutants in circulating tumor DNA and follow-up of BRCA1 mutation carriers: The CirCA01 study. [2015] Cancer Research (75) 9 suppl: OT1-2-04. Impact factor: 8,556 53. Bisio A., Latorre E., Andreotti V., Bressac-de Paillerets B., Harland M., Scarra G.B., Ghiorzo P., Spitale R.C., Provenzani A., and Inga A. The 5 ‘-untranslated region 38 of p16(INK4a) melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding. [2015] Oncotarget (6) 37: 39980-39994. Impact factor: 5,008 54. Biya J., Caramella C., Lindsay C.R., Planchard D., and Besse B. A Long-Term Spinal Intramedullary Response to Ceritinib in ALK Rearranged NonSmall-Cell Lung Cancer. [2015] Journal of Thoracic Oncology (10) 6: E44-E45. Impact factor: 5,040 55. Blanc L., Papoin J., Debnath G., Vidal M., Amson R., Telerman A., An X., and Mohandas N. Abnormal erythroid maturation leads to microcytic anemia in the TSAP6/Steap3 null mouse model. [2015] American Journal of Hematology (90) 3: 235-241. Impact factor: 5 56. Blay J., Bertuzzi A., Bielack S., Bjerkehagen B., Bonvalot S., Boukovinas I., Bruzzi P., Dei Tos A., Dileo P., Eriksson M., Fedenko A., Ferrari A., Ferrari S., Gelderblom H., Grimer R., Gronchi A., Haas R., Hall K., Hohenberger P., Issels R., Joensuu H., Judson I., Le Cesne A., Litiere S., Martin-Broto J., Merimsky O., Montemurro M., Morosi C., Picci P., Ray-coquard I., Reichardt P., Rutkowski P., Schlemmer M., Stacchiotti S., Torri V., Trama A., Van Coevorden F., Van der Graaf W., Vanel D., Wardelmann E., and Casali P. Gastrointestinal Stromal Tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (vol 25, pg iii21, 2014). [2015] Annals of Oncology (26) suppl 5: V174-V175. Impact factor: 9,269 57. 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An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers. [2015] Breast Cancer Research (17) 1: 61. Impact factor: 5,211 60. Bloy N., Sauvat A., Chaba K., Buque A., Humeau J., Bravo-San Pedro J.M., Bui J., Kepp O., Kroemer G., and Senovilla L. Morphometric analysis of immunoselection against hyperploid cancer cells. [1-12-2015] Oncotarget (6) 38: 41204-41215. Impact factor: 5,008 61. Bloy N., Buque A., Aranda F., Castoldi F., Eggermont A., Cremer I., Sautes-Fridman C., Fucikova J., Galon J., Spisek R., Tartour E., Zitvogel L., Kroemer G., and Galluzzi L. Trial watch: Naked and vectored DNAbased anticancer vaccines. [2015] Oncoimmunology (4) 5: e1026531. Impact factor: 7,644 62. Blumenschein G., Smit E., Planchard D., Kim D., Cadranel J., De Pas T., Dunphy F., Udud K., Ahn M., Hanna N., Kim J., Mazieres J., Kim S., Baas P., Rappold E., Redhu S., Puski A., Wu F., and Jaenne P. A randomized phase II study of the MEK1/MEK2 inhibitor trametinib (GSK1120212) compared with docetaxel in KRAS-mutant advanced non-smallcell lung cancer (NSCLC). [2015] Annals of Oncology (26) 5: 894-901. Impact factor: 9,269 63. Bluthgen M., V, Caramella C., Faivre L., Rosellini S., Facchinetti F., Haspinger E., Ferte C., Ammari S., Michiels S., Soria J., and Besse B. Prognostic value of texture analysis in advanced non-small cell lung cancer (NSCLC). [2015] European Journal of Cancer (51) suppl 3: S645-S646. Impact factor: 6,163 64. Bodo S., Svrcek M., Sourrouille I., CuillieresDartigues P., Ledent T., Dumont S., Dinard L., Lafitte P., Capel C., Collura A., Buhard O., Wanherdrick K., Chalastanis A., Penard-Lacronique V., Fabiani B., Flejou J.F., Brousse N., Beaugerie L., Duval A., and Muleris M. Azathioprine induction of tumors with microsatellite instability: Risk evaluation using a mouse model. [2015] Oncotarget (6) 28: 2496924977. Impact factor: 5,008 65. Body J.J., Bone H.G., De Boer R.H., Stopeck A., Van Poznak C., Damiao R., Fizazi K., Henry D.H., Ibrahim T., Lipton A., Saad F., Shore N., Takano T., Shaywitz A.J., Wang H., Bracco O.L., Braun A., and Kostenuik P.J. Hypocalcaemia in patients with metastatic bone disease treated with denosumab. [2015] European Journal of Cancer (51) 13: 1812-1821. Impact factor: 6,163 66. Bollard J., Massoma P., Vercherat C., Blanc M., Lepinasse F., Gadot N., Couderc C., Poncet G., Walter T., Joly M.O., Hervieu V., Scoazec J.Y., and Roche C. The axon guidance molecule Semaphorin 3F is a negative regulator of tumor progression and proliferation in ileal neuroendocrine tumors. [2015] Oncotarget (6) 34: 36731-36745. Impact factor: 5,008 67. Bompas E., Le Cesne A., Tresch-Bruneel E., Lebellec L., Laurence V., Collard O., Saada-Bouzid E., Isambert N., Blay J., Amela E., Salas S., Chevreau C., Bertucci F., Italiano A., Clisant S., and Penel N. 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Neoadjuvant treatment with docetaxel plus lapatinib, trastuzumab, or both followed by an anthracycline-based chemotherapy in HER2-positive breast cancer: results of the randomised phase II EORTC 10054 study. [2015] 40 Annals of Oncology (26) 2: 325-332. Impact factor: 9,269 70. Bonnet F., Affret A., Boutron-Ruault M.C., Balkau B., Clavel-Chapelon F., and Fagherazzi G. Association Between Handedness and Type 2 Diabetes: The E3N Study. [2015] Diabetes Care (38) 12: e199. Impact factor: 8,934 71. Bonneterre J., Bosq J., Alleaume C., Gilles E., Jamme P., and Zukiwski A. Triple negative breast cancer, the impact of isotype-specific progesterone receptor antibodies on the diagnosis results. [2015] Cancer Research (75) 9 suppl: P5-02-13. Impact factor: 8,556 72. Bonora M., Wieckowski M., Chinopoulos C., Kepp O., Kroemer G., Galluzzi L., and Pinton P. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. 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Early tumor shrinkage as a predictor for long-term outcome in patients (pts) with unresectable liver metastases from wt-KRAS colorectal cancer (LM-CRC) treated with hepatic artery infusion (HAI) of Irinotecan, 5-Fluorouracil and Oxaliplatin plus intravenous Cetuximab (IV-Cet) after failure of one to three systemic protocols (European phase II clinical trial NCT00852228). [2015] European Journal of Cancer (51) suppl 3: S348-S348. Impact factor: 6,163 75. Bouda C., Traore F., Atteby J., Raquin M., Guedenon K., Pondy A., Moreira C., Harif M., and Patte C. A multicenter study of the Groupe Franco Africain d’Oncologie Pediatrique for the treatment of children with Burkitt lymphoma in sub-Saharan countries. [2015] British Journal of Haematology (171) suppl 1: 79-79. Impact factor: 5,401 76. Boudra M.T., Bolin C., Chiker S., Fouquin A., Zaremba T., Vaslin L., Biard D., Cordelières F.P., Mégnin- Chanet F., Favaudon V., Fernet M., Pennaneach V., and Hall J. 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Hypertension (HTN) as a potential biomarker of efficacy in pazopanib-treated patients with advanced non-adipocytic soft tissue sarcoma. A retrospective study based on European Organisation for Research and Treatment of Cancer (EORTC) 62043 and 62072 trial. [2015] European Journal of Cancer (51) 17: 2615-2623. Impact factor: 6,163 153. Duployez N., Antony-Debre I., Bucci M., Geffroy S., Boissel N., Berthon C., Dhedin N., Leblanc T., Rea D., Heller P., Favier R., Latger-Cannard V., Mozziconacci M., Nelken B., Raslova H., and Preudhomme C. Additional Molecular Aberrations Leading to Leukemic Transformation in Patients with Familial Platelet Disorder. [2015] Haematologica (100) suppl 1: 208-208. Impact factor: 6,671 154. Duran G.E., Wang Y.C., Francisco E.B., Rose J.C., Martinez F.J., Coller J., Brassard D., Vrignaud P., and Sikic B.I. Mechanisms of resistance to cabazitaxel. [2015] Molecular Cancer Therapeutics (14) 1: 193201. Impact factor: 5,579 155. Dyakonova E.S., Koval V.V., Lomzov A.A., Ishchenko A.A., and Fedorova O.S. The role of His-83 of yeast apurinic/apyrimidinic endonuclease Apn1 in catalytic incision of abasic sites in DNA. [2015] Biochimica et Biophysica Acta - General Subjects (1850) 6: 1297-1309. Impact factor: 5,083 156. Eberhardt W., De Ruysscher D., Weder W., Le Pechoux C., De Leyn P., Hoffmann H., Westeel V., Stahel R., Felip E., and Peters S. 2nd ESMO Consensus Conference in Lung Cancer: locally advanced stage III non-small-cell lung cancer. [2015] Annals of Oncology (26) 8: 1573-1588. Impact factor: 9,269 157. Edmands W.M., Ferrari P., Rothwell J.A., Rinaldi S., Slimani N., Barupal D.K., Biessy C., Jenab M., Clavel-Chapelon F., Fagherazzi G., Boutron-Ruault M.C., Katzke V.A., Kuehn T., Boeing H., Trichopoulou A., Lagiou P., Trichopoulos D., Palli D., Grioni S., Tumino R., Vineis P., Mattiello A., Romieu I., and Scalbert A. 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Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC) . [2015] American Journal of Clinical Nutrition (101) 3: 613621. Impact factor: 6,703 159. El-Daher M.T., Hangen E., Bruyere J., Poizat G., AlRamahi I., Pardo R., Bourg N., Souquere S., Mayet C., Pierron G., Leveque-Fort S., Botas J., Humbert S., and Saudou F. Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation. [2015] Embo Journal (34) 17: 2255-2271. Impact factor: 9,643 160. El Kababri M., Cherkaoui S., Hessissen L., Madani A., Khattab M., Quessar A., Barsaoui S., Cherif N., Raquin M., Raphael M., Patte C., and Harif M. Childhood Burkitt lymphoma in North Africa: a study of the French-African Pediatric Oncology Group (GFAOP). [2015] British Journal of Haematology (171) suppl 1: 2-2. Impact factor: 5,401 161. Elias D., Faron M., Iuga B.S., Honore C., Dumont F., Bourgain J.L., Dartigues P., Ducreux M., and Goere D. Prognostic Similarities and Differences in Optimally Resected Liver Metastases and Peritoneal Metastases From Colorectal Cancers. [2015] Annals of surgery (261) 1: 157-163 . Impact factor: 8,569 1 62. Engeset D., Braaten T., Teucher B., Kuhn T., Bueno-de-Mesquita H., Leenders M., Agudo A., Bergmann M.M., Valanou E., Naska A., Trichopoulou A., Key T.J., Crowe F.L., Overvad K., Sonestedt E., Mattiello A., Peeters P.H., Wennberg M., Jansson J.H., Boutron-Ruault M.C., Dossus L., Dartois L., Li K., Barricarte A., Ward H., Riboli E., Agnoli C., Maria Huerta J., Sanchez M.J., Tumino R., Altzibar J.M., Vineis P., Masala G., Ferrari P., Muller D.C., Johansson M., Luisa Redondo M., Tjønneland A., Olsen A., Olsen K.S., Brustad M., Skeie G., and Lund E. Fish consumption and mortality in the European Prospective Investigation into Cancer and Nutrition cohort. 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