Clinical Cancer Research
Table of
Contents
March 1, 2016 Volume 22 Number 5
1067
Highlights of This Issue 1029
SPECIAL FEATURES
Beata Holkova, Adriana Zingone, Maciej Kmieciak,
Prithviraj Bose, Ashraf Z. Badros, Peter M. Voorhees,
Rachid Baz, Neha Korde, Hui-Yi Lin, Jin-Qiu Chen,
Michelle Herrmann, Liqiang Xi, Mark Raffeld, Xiuhua Zhao,
Wen Wan, Mary Beth Tombes, Ellen Shrader,
Caryn Weir-Wiggins, Heidi Sankala, Kevin T. Hogan,
Austin Doyle, Christina M. Annunziata, Martha Wellons,
John D. Roberts, Daniel Sullivan, Ola Landgren, and
Steven Grant
CCR Translations
1031
Impact of Metformin on Advanced Pancreatic
Cancer Survival: Too Little, Too Late?
Yu-Xiao Yang and Anil K. Rustgi
See related article, p. 1076
1034
ESR1 Mutations in Breast Cancer: Proof-ofConcept Challenges Clinical Action
1076
Guowei Gu and Suzanne A.W. Fuqua
See related article, p. 1130
New Strategies in Myeloproliferative Neoplasms:
The Evolving Genetic and Therapeutic Landscape
Ami B. Patel, Nadeem A. Vellore, and Michael W. Deininger
1086
Molecular Pathways
1048
1095
A First-in-Human Phase I Study of the Oral p38
MAPK Inhibitor, Ralimetinib (LY2228820
Dimesylate), in Patients with Advanced Cancer
Amita Patnaik, Paul Haluska, Anthony W. Tolcher,
Charles Erlichman, Kyriakos P. Papadopoulos,
Janet L. Lensing, Muralidhar Beeram, Julian R. Molina,
Drew W. Rasco, Rebecca R. Arcos, Claudia S. Kelly,
Sameera R. Wijayawardana, Xuekui Zhang, Louis F. Stancato,
Robert Bell, Peipei Shi, Palaniappan Kulanthaivel,
Celine Pitou, Lynette B. Mulle, Daphne L. Farrington,
Edward M. Chan, and Matthew P. Goetz
Perspectives
New Life for Immunotoxin Cancer Therapy
Raffit Hassan, Christine Alewine, and Ira Pastan
CANCER THERAPY: CLINICAL
1059
Pathological T0 Following Cisplatin-Based
Neoadjuvant Chemotherapy for Muscle-Invasive
Bladder Cancer: A Network Meta-analysis
Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak,
Hyeon Hoe Kim, and Ja Hyeon Ku
Molecular Pathways: Mechanism of Action for
Talimogene Laherparepvec, a New Oncolytic Virus
Immunotherapy
Frederick J. Kohlhapp and Howard L. Kaufman
1055
(Ir)relevance of Metformin Treatment in Patients
with Metastatic Pancreatic Cancer: An Open-Label,
Randomized Phase II Trial
Michele Reni, Erica Dugnani, Stefano Cereda, Carmen Belli,
Gianpaolo Balzano, Roberto Nicoletti, Daniela Liberati,
Valentina Pasquale, Marina Scavini, Paola Maggiora,
Valeria Sordi, Vito Lampasona, Domenica Ceraulo,
Gaetano Di Terlizzi, Claudio Doglioni, Massimo Falconi,
and Lorenzo Piemonti
See related commentary, p. 1031
CCR New Strategies
1037
A Phase II Trial of AZD6244 (Selumetinib,
ARRY-142886), an Oral MEK1/2 Inhibitor, in
Relapsed/Refractory Multiple Myeloma
A Phase I/II Multicenter, Open-Label Study of the
Oral Histone Deacetylase Inhibitor Abexinostat in
Relapsed/Refractory Lymphoma
PERSONALIZED MEDICINE AND IMAGING
1103
Andrew M. Evens, Sriram Balasubramanian, Julie M. Vose,
Wael Harb, Leo I. Gordon, Robert Langdon, Julian Sprague,
Mint Sirisawad, Chitra Mani, Jeanne Yue, Ying Luan,
Sharon Horton, Thorsten Graef, and Nancy L. Bartlett
Detection of T790M, the Acquired Resistance EGFR
Mutation, by Tumor Biopsy versus Noninvasive
Blood-Based Analyses
Tilak K. Sundaresan, Lecia V. Sequist, John V. Heymach,
Gregory J. Riely, Pasi A. J€anne, Walter H. Koch,
James P. Sullivan, Douglas B. Fox, Robert Maher,
Alona Muzikansky, Andrew Webb, Hai T. Tran, Uma Giri,
Martin Fleisher, Helena A. Yu, Wen Wei, Bruce E. Johnson,
Thomas A. Barber, John R. Walsh, Jeffrey A. Engelman,
Shannon L. Stott, Ravi Kapur, Shyamala Maheswaran,
Mehmet Toner, and Daniel A. Haber
iv
Table of Contents
1111
1161
Association between GWAS-Derived rs966423
Genetic Variant and Overall Mortality in Patients
with Differentiated Thyroid Cancer
Michał Swierniak, Anna W
ojcicka,
Małgorzata Czetwerty
nska, Joanna Długosi
nska,
El_zbieta Stachlewska, Wojciech Gierlikowski, Adam Kot,
Barbara G
ornicka, Łukasz Koperski, Magdalena Bogda
nska,
Wiesław Wiechno, and Krystian Ja_zd_zewski
1120
Christopher M. Jackson, Christina M. Kochel,
Christopher J. Nirschl, Nicholas M. Durham,
Jacob Ruzevick, Angela Alme, Brian J. Francica, Jimmy Elias,
Andrew Daniels, Thomas W. Dubensky Jr, Peter Lauer,
Dirk G. Brockstedt, Emily G. Baxi, Peter A. Calabresi,
Janis M. Taube, Carlos A. Pardo, Henry Brem,
Drew M. Pardoll, Michael Lim, and Charles G. Drake
In Vivo Detection of Succinate by Magnetic
Resonance Spectroscopy as a Hallmark of SDHx
Mutations in Paraganglioma
1173
Charlotte Lussey-Lepoutre, Alexandre Bellucci,
Aurelie Morin, Alexandre Buffet, Laurence Amar,
Maxime Janin, Chris Ottolenghi, Franck Zinzindohoue,
Gwennhael Autret, Nelly Burnichon, Estelle Robidel,
Benjamin Banting, Sebastien Fontaine,
Charles-Andre Cuenod, Paule Benit, Pierre Rustin,
Philippe Halimi, Laure Fournier,
Anne-Paule Gimenez-Roqueplo, Judith Favier, and
Bertrand Tavitian
1130
1185
Preclinical Efficacy of the MDM2 Inhibitor
RG7112 in MDM2-Amplified and TP53 Wild-type
Glioblastomas
Maite Verreault, Charlotte Schmitt, Lauriane Goldwirt,
Kristine Pelton, Samer Haidar, Camille Levasseur,
Jeremy Guehennec, David Knoff, Marianne Labussiere,
Yannick Marie, Azra H. Ligon, Karima Mokhtari,
Kh^e Hoang-Xuan, Marc Sanson, Brian M. Alexander,
Patrick Y. Wen, Jean-Yves Delattre, Keith L. Ligon, and
Ahmed Idbaih
Sensitive Detection of Mono- and Polyclonal ESR1
Mutations in Primary Tumors, Metastatic Lesions,
and Cell-Free DNA of Breast Cancer Patients
1197
Mithramycin Depletes Specificity Protein 1 and
Activates p53 to Mediate Senescence and
Apoptosis of Malignant Pleural Mesothelioma
Cells
Mahadev Rao, Scott M. Atay, Vivek Shukla, Young Hong,
Trevor Upham, R. Taylor Ripley, Julie A. Hong,
Mary Zhang, Emily Reardon, Patricia Fetsch,
Markku Miettinen, Xinmin Li, Cody J. Peer, Tristan Sissung,
William D. Figg, Assunta De Rienzo, Raphael Bueno, and
David S. Schrump
CANCER THERAPY: PRECLINICAL
Targeting of BCL2 Family Proteins with ABT-199
and Homoharringtonine Reveals BCL2- and
MCL1-Dependent Subgroups of Diffuse Large
B-Cell Lymphoma
1211
Magdalena Klanova, Ladislav Andera, Jan Brazina,
Jan Svadlenka, Simona Benesova, Jan Soukup,
Dana Prukova, Dana Vejmelkova, Radek Jaksa,
Karel Helman, Petra Vockova, Lucie Lateckova,
Jan Molinsky, Bokang Calvin Lenyeletse Maswabi,
Mahmudul Alam, Roman Kodet, Robert Pytlik,
Marek Trneny, and Pavel Klener
1150
PD-1 Blockade Boosts Radiofrequency
Ablation–Elicited Adaptive Immune
Responses against Tumor
Liangrong Shi, Lujun Chen, Changping Wu, Yibei Zhu,
Bin Xu, Xiao Zheng, Mingfen Sun, Wen Wen, Xichao Dai,
Min Yang, Quansheng Lv, Binfeng Lu, and Jingting Jiang
Peilu Wang, Amir Bahreini, Rekha Gyanchandani,
Peter C. Lucas, Ryan J. Hartmaier, Rebecca J. Watters,
Amruth R. Jonnalagadda, Humberto E. Trejo Bittar,
Aaron Berg, Ronald L. Hamilton, Brenda F. Kurland,
Kurt R. Weiss, Aju Mathew, Jose Pablo Leone,
Nancy E. Davidson, Marina N. Nikiforova,
Adam M. Brufsky, Tadeu F. Ambros, Andrew M. Stern,
Shannon L. Puhalla, Adrian V. Lee, and Steffi Oesterreich
See related commentary, p. 1034
1138
Systemic Tolerance Mediated by Melanoma Brain
Tumors Is Reversible by Radiotherapy and
Vaccination
Sorafenib Inhibition of Mcl-1 Accelerates ATRAInduced Apoptosis in Differentiation-Responsive
AML Cells
Rui Wang, Lijuan Xia, Janice Gabrilove, Samuel Waxman,
and Yongkui Jing
1222
A 13 mer LNA-i-miR-221 Inhibitor Restores Drug
Sensitivity in Melphalan-Refractory Multiple
Myeloma Cells
Annamaria Gulla, Maria Teresa Di Martino,
Maria Eugenia Gallo Cantafio, Eugenio Morelli,
Nicola Amodio, Cirino Botta, Maria Rita Pitari,
Santo Giovanni Lio, Domenico Britti,
Maria Angelica Stamato, Teru Hideshima,
Nikhil C. Munshi, Kenneth C. Anderson,
Pierosandro Tagliaferri, and Pierfrancesco Tassone
SAR405838: A Novel and Potent Inhibitor of the
MDM2:p53 Axis for the Treatment of
Dedifferentiated Liposarcoma
Kate Lynn J. Bill, Jeannine Garnett, Isabelle Meaux,
XiaoYen Ma, Chad J. Creighton, Svetlana Bolshakov,
Cedric Barriere, Laurent Debussche, Alexander J. Lazar,
Bethany C. Prudner, Lucia Casadei, Danielle Braggio,
Gonzalo Lopez, Abbie Zewdu, Hemant Bid, Dina Lev, and
Raphael E. Pollock
v
Table of Contents
1274
BIOLOGY OF HUMAN TUMORS
1234
PRAME as an Independent Biomarker for
Metastasis in Uveal Melanoma
Sunny Guin, Yuanbin Ru, Neeraj Agarwal, Carolyn R. Lew,
Charles Owens, Giacomo P. Comi, and Dan Theodorescu
Matthew G. Field, Christina L. Decatur, Stefan Kurtenbach,
G€
ulçin Gezgin, Pieter A. van der Velden, Martine J. Jager,
Kaleigh N. Kozak, and J. William Harbour
1243
1284
Competitive Binding Between Id1 and E2F1 to
Cdc20 Regulates E2F1 Degradation and
Thymidylate Synthase Expression to Promote
Esophageal Cancer Chemoresistance
LETTER TO THE EDITOR
Inactivation of Hippo Pathway Is Significantly
Associated with Poor Prognosis in Hepatocellular
Carcinoma
1295
VEGF and VTE Risk in Cancer Patients—Letter
Patrizia Ferroni, Silvia Riondino, Fiorella Guadagni, and
Mario Roselli
Bo Hwa Sohn, Jae-Jun Shim, Sang-Bae Kim, Kyu Yun Jang,
Soo Mi Kim, Ji Hoon Kim, Jun Eul Hwang, Hee-Jin Jang,
Hyun-Sung Lee, Sang-Cheol Kim, Woojin Jeong,
Sung Soo Kim, Eun Sung Park, Jeonghoon Heo,
Yoon Jun Kim, Dae-Ghon Kim, Sun-Hee Leem,
Ahmed Kaseb, Manal M. Hassan, Minse Cha, In-Sun Chu,
Randy L. Johnson, Yun-Yong Park, and Ju-Seog Lee
1265
Elevated Coexpression of KITENIN and the ErbB4
CYT-2 Isoform Promotes the Transition from
Colon Adenoma to Carcinoma Following APC
loss
Jeong A Bae, Dhong Hyo Kho, Eun Gene Sun,
Yoo-Seung Ko, Somy Yoon, Kyung Hwa Lee,
Kyu Youn Ahn, Jae Hyuk Lee, Young Eun Joo,
Ik Joo Chung, Sug Hyung Lee, Hangun Kim, and
Kyung Keun Kim
Bin Li, Wen Wen Xu, Xin Yuan Guan, Yan Ru Qin,
Simon Law, Nikki Pui Yue Lee, Kin Tak Chan,
Pui Ying Tam, Yuk Yin Li, Kwok Wah Chan,
Hiu Fung Yuen, Sai Wah Tsao, Qing Yu He, and
Annie L.M. Cheung
1256
Loss of Glycogen Debranching Enzyme AGL
Drives Bladder Tumor Growth via Induction of
Hyaluronic Acid Synthesis
CORRECTIONS
Defining a New Prognostic Index for Stage I
Nonseminomatous Germ Cell Tumors Using
CXCL12 Expression and Proportion of Embryonal
Carcinoma
1296
Correction: Differential Functions of Growth
Factor Receptor–Bound Protein 7 (GRB7) and Its
Variant GRB7v in Ovarian Carcinogenesis
1297
Correction: p73 Expression Is Associated with the
Cellular Radiosensitivity in Cervical Cancer after
Radiotherapy
Duncan C. Gilbert, Reem Al-Saadi, Khin Thway,
Ian Chandler, Daniel Berney, Rhian Gabe,
Sally P. Stenning, Joan Sweet, Robert Huddart, and
Janet M. Shipley
AC icon indicates Author Choice
CME icon indicates that this article is available for continuing medical education credit at http://cme.aacrjournals.org
For more information please visit www.aacrjournals.org
vi
Table of Contents
ABOUT THE COVER
The cover shows a section of a B16 melanoma brain tumor from a mouse treated with a listeriabased cancer vaccine in combination with focal radiation therapy. Hematoxylin and eosin staining
demonstrates lymphocytes extravasating from tumor vessels and infiltrating into the tumor mass.
For details, see the article by Jackson and colleagues on page 1161 of this issue.
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