Wednesday
May 8, 2013
LIFE-CHANGING RESEARCH
MAY 5 – 9 | SEATTLE
266
426 Macular Disease other than AMD II
[RE] #4510-4516
427 Ocular Immune Responses [IM]
#4517-4523
428 Uveal Melanoma: Experimental
Therapeutics [AP] #4524-4530
429 A Global View of Posterior
Capsule Opacification —
Minisymposium [LE] #4531-4534
430 Physiologic Vascularization in
Retinopathies [RC] #4535-4541
404 DR: Therapeutic Effects [RE]
#4023-4029
405 Host Responses to Ocular
Herpesvirus Infection — What Have
We Learned and What Is the Future
Direction? — Minisymposium [IM, CO]
#4030-4034
406 Myopia and Emmetropization [AP]
#4035-4041
407 Cell Biology Impacts Lens Function
[LE] #4042-4048
408 Differentiation of Stem and iPS
Cells [RC] #4049-4055
6E
606-607
608
609
TCC LL 4/5
410 Spatial Vision, Visual
Psychophysics and Aging II [VI]
#4063-4068
434 Genetics, Development and Aging
[VN] #4562-4568
412 Photoreceptors: Structure,
Transduction, Signaling [VN] #40764082
TCC 304
432 Refractive Errors, Myopia II [VI]
#4549-4554
435 Neuro-Ophthalmology: Novel
Treatments and Mechanisms of
Disease [EY] #4569-4575
433 Stroma Keratocytes, Development
and Dystrophies [CO] #4555-4561
411 Keratoconus and Biomechanics
[CO] #4069-4075
TCC 305
450 Getting Published: The Good, the
Bad, and the Ugly
449 Managing Your Research, Teaching
and Service: “Dollarly/Scholarly”
458 New Paradigms and Emerging
Techniques for Minimalist Macular
Photocoagulation — SIG [RE]
448 Multidisciplinary Ophthalmic
Imaging Group: Functional Optical
Imaging [MOI]
453 NIH-CSR Peer Review Workshop
452 Pizza with the Experts #2
457 Dietary Factors and Eye
Health — SIG [CO, BI, RE, GL]
431 Eye Care: Who’s Not Getting It and 451 Indo-US Collaborative Vision
Why It Matters [CL] #4542-4548
Research Program
TCC 303
TCC 301/302
618-620
615-617
409 Purine Signaling in the Eye:
Role in Health and Disease —
Minisymposium [PH, CO, RC]
#4056-4062
425 AMD: Novel and Combination
Therapies [RE] #4504-4509
403 Retinitis Pigmentosa II [RE]
#4016-4022
6C
611-614
455 Diabetic Retinopathy: Where We Are
and a Path to Progress — SIG [RE]
424 Genetics I [GL] #4497-4503
402 New Ideas [GL] #4009-4015
6B
456 Epigenetic Mechanism and Ocular
Diseases —SIG [RC]
454 What Role Do Mueller Glial Cells
Play in Retinal Pathology? — SIG
[RC, RE]
401 Biochemistry of Glaucoma [BI]
#4002-4008
1–2:30pm
Workshop/SIG
6A
Room
8:30–10:15am
11am–12:45pm
Wednesday, May 8
464 Advances in Ocular Genetics
[GEN] #4971-4977
465 Amblyopia: Neural Mechanisms
and Treatment [EY, VI] #4978-4984
463 Transplanted and Endogenous
Cells as Effectors of Outer Retinal
Repair — Minisymposium [RC]
#4966-4970
462 Lens Proteins/Physical Chemistry
[LE] #4959-4965
461 Retinal Detachment II [RE]
#4952-4958
460 ROP: Management [RE] #49454951
459 Neuroprotection [GL] #4938-4944
2:45–4:30pm
481B Friedenwald Award and
Lecture
ARVO Karaoke!
Club Noc Noc
9pm–12Midnight
ARVO Classical Concert
Nordstrom Recital Hall,
Benaroya Hall
8–10pm
Networking Happy Hour,
Exhibit Halls, 4:30–6pm
NAEVR Central,
Skybridge, 9am–5pm
Exhibit Halls, 11am–6pm
481A Cogan Award and
Lecture
5:30–6:15pm6:30–7:15pm
267
Accommodation and Presbyopia Correction [VI]
Antibiotics and Corneal Disease [PH, CO]
Dry Eye and Lacrimal Gland IV [CO]
Neuro-Ophthalmology: Papilledema, Characterization
of Rare Diseases, and Methods of Evaluation [EY]
Eye Care [CL]
Ocular Trauma [CL]
Ocular Blood Flow; Surgery and Wound Healing [GL]
417
418
419
420
421
422
423
AMD I, BI [BI]
Translational Approaches in AMD and DR [RC]
Retinal Flow and VEGF [PH, RC]
Ocular Nanoimaging, Nanobiosensors and
Nanodiagnostics [NT]
Strabismus: Treatment Methods [EY]
Corneal Development, Differentiation, Dystrophies,
Genetics [CO]
Surgery and Wound Healing [GL]
Imaging III [GL]
Choroid and Sclera Imaging [MOI]
Imaging of Animal Models [MOI]
Imaging I [RE]
DME: OCT and Function [RE]
437
438
439
440
441
442
443
444
445
446
447
Session
Title
436
Session
Number
Uveal Melanoma [AP, PH]
416
11am–12:45pm
Retinal and Photoreceptor Degeneration II: Cell Biology [RC] #4177-4202
415
(D0182-D0236)
(D0114-D0126)
(D0021-D0066)
(D0001-D0020)
(C0046-C0100)
(C0022-C0045)
(B0287-B0320)
(B0196-B0242)
(B0170-B0195)
(A0048-A0094)
(A0001-A0047)
#4917-4937
#4898-4916
#4871-4897
#4853-4870
#4798-4852
#4743-4797
#4718-4742
#4705-4717
#4674-4704
#4628-4673
#4595-4627
#4576-4594
(D0356-D0376)
(D0337-D0355)
(D0310-D0336)
(D0292-D0309)
(D0237-D0291)
(D0127-D0181)
(C0101-C0125)
(B0274-B0286)
(B0243-B0273)
(B0092-B0137)
(A0146-A0178)
(A0095-A0113)
ProgramBoard
Number
Number
#4442-4496
#4429-4441
#4383-4428
#4363-4382
#4308-4362
#4284-4307
#4250-4283
#4203-4249
#4130-4176
AMD III, RE [RE]
414
#4083-4129
ProgramBoard
Number
Number
AMD II, RE [RE]
Session
Title
413
Session
Number
8:30–10:15am
Wednesday, May 8 n Posters
Drug Delivery III [PH]
Dysfunction in Disease: Translational Studies [VN]
Dysfunction in Disease: Clinical Studies [VN]
Retinal Development II: Retina and Vasculature [RC]
Myopia II [AP]
Non-infectious Inflammation [IM]
468
469
470
471
472
473
Vision Function and Quality of Life [CL]
Oculoplastics and Orbital Disease: Prognosis,
Diagnosis and Outcomes [EY]
478
479
#5340-5352
#5306-5339
#5259-5305
#5238-5258
#5223-5237
#5207-5222
#5186-5206
#5166-5185
#5134-5165
#5101-5133
#5076-5100
#5043-5075
#5017-5042
#4985-5016
(D0101-D0113)
(D0067-D0100)
(C0178-C0224)
(C0157-C0177)
(C0142-C0156)
(C0126-C0141)
(C0001-C0021)
(B0321-B0340)
(B0138-B0169)
(B0059-B0091)
(B0034-B0058)
(B0001-B0033)
(A0179-A0204)
(A0114-A0145)
ProgramBoard
Number
Number
4:30–5:30pm: All Posters — authors will be present at poster boards
4:30–6pm: Networking Happy Hour in Exhibit/Poster Halls
Poster board numbers indicate location:
Poster Area A and B = South Exhibit Hall; Poster Area C and D = North Exhibit Hall
Corneal Cross-linking and Keratoconus [CO]
Corneal Stroma and Keratocytes [CO]
Corneal Wound Repair, Transparency II [CO, BI]
477
476
475
Corneal Infection/Inflammation I [IM]
Visual Functions in AMD [VI]
467
474
AMD II, BI [BI]
Session
Title
466
Session
Number
2:45–4:30pm
NOTES
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268
266
Wednesday – Papers/Minisymposium – 4002 – 4021
6A
6B
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Biochemistry/Molecular Biology / Biochemistry/
Molecular Biology
Glaucoma
401 Biochemistry of Glaucoma
Moderators: Stanislav I. Tomarev and
Ernst R. Tamm
4002 — 8:30 Myocilin affects differentiation
of oligodendrocytes and regulates myelination
of the optic nerve via Lingo-1/RhoA signaling.
Stanislav I. Tomarev1, H. Kwon1, N. Nakaya1, M.
S. Abu-Asab2. 1SRGCB, LRCMB, National Eye
Institute, Bethesda, MD; 2Histopathology Core
Facility, National Eye Institute, Bethesda, MD
4003 — 8:45 Genomewide DNA methylation
analysis of human trabecular meshwork
cells with dexamethasone stimulation. Akira
Matsuda, N. Ebihara, A. Murakami. Department
of Ophthalmology, Juntendo Univ School of Med,
Tokyo, Japan *CR
4004 — 9:00 Stabilization of Myocilin with
Small Molecules Prevents Its Aggregation.
Raquel L. Lieberman, S. E. Hill, R. K. Donegan, K.
C. Turnage. School of Chemistry & Biochemistry,
Georgia Institute of Technology, Atlanta, GA
4006 — 9:30 Subcellular mislocalization and
loss of function of mutant Gpnmb proteins.
Alexander C. Theos. Human Science, Georgetown
University, Washington, DC
4007 — 9:45 Cochlin and phosphatidylcholines
interact with SLC44A2 channel on the
trabecular meshwork cells. Sanjoy K.
Bhattacharya, M. Martinez, A. Aljohani, R. K. Lee.
Bascom Palmer Eye Institute, Univ of Miami Miller
Sch of Med, Miami, FL *CR
4008 — 10:00 Disruption of the homeostatic
balance between TGF-β and BMPs in the
outflow tissues of the CTGF-based Glaucoma
mouse model. Sabrina Kuespert, E. R. Tamm, R.
Fuchshofer. University Regensburg, Institut of
Human Anatomy and Embryology, Regensburg,
Germany
Moderators: Jonathan G. Crowston, Peng T. Khaw
and George A. Cioffi
4009 — 8:30 Glucose-induced Temporary
Visual Recovery in Human Glaucoma: A
Prospective, Double-blind, Randomised Study.
Robert J. Casson, G. Chidlow, A. Ebneter, G.
Han, J. Gilhotra, J. P. Wood. SA Institute of
Ophthalmology, SA Inst of Ophthalmol, Adelaide
Univ, Adelaide, SA, Australia f
4010 — 8:45 Radiation Treatment Does Not
Protect the Rat Optic Nerve from Elevated
Intraocular Pressure (IOP)-Induced Injury.
Elaine C. Johnson, W. Cepurna, J. C. Morrison.
Ophthalmology, Casey Eye Institute-OHSU,
Portland, OR
4011 — 9:00 Estrogen Pathway Polymorphisms
in Relation to Primary Open Angle Glaucoma:
A Gender-Specific Analysis from Patients in the
United States. Louis R. Pasquale1, 2, S. Loomis1,
B. Yaspan3, J. H. Kang2, R. N. Weinreb6, J. E.
Richards7, M. A. Hauser4, J. L. Haines5, J. L.
Wiggs1. 1Ophthalmology, Mass Eye & Ear Infirmary,
Boston, MA; 2Medicine, Brigham and Women’s
Hospital, Boston, MA; 3Genentech, Inc, San
Francisco, CA; 4Ophthalmology, Duke University,
Durham, NC; 5Center for Human Genetics
Research, Vanderbilt University, Nashville,
TN; 6Ophthalmology, UCSD, San Diego, CA;
7
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI *CR
4012 — 9:15 A Novel Device for Clinical
Measurement of Corneal Elasticity. Christopher
K. Leung1, C. Ye1, M. Ko2, L. Leung2, D. Lam2.
1
Ophthalmology and Visual Sciences, The Chinese
University of Hong Kong, Hong Kong, Hong Kong;
2
Mechanical Engineering, Hong Kong University of
Science and Technology, Hong Kong, Hong Kong
*CR
4013 — 9:30 A Potential Role for the
Hypothalamic Orexin System in Mediating
Intraocular Pressure Fluctuations. Brian
C. Samuels1, N. Hammes1, P. L. Johnson2, A.
Shekhar3, 4. 1Department of Ophthalmology, Eugene
& Marilyn Glick Eye Inst, Ind Univ, Indianapolis,
IN; 2Department of Anatomy, Indiana University,
Indianapolis, IN; 3Department of Psychiatry,
Indiana University, Indianapolis, IN; 4Clinical and
Translational Sciences Institute, Indiana University,
Indianapolis, IN *CR
4014 — 9:45 Pulse-induced Trabecular
Meshwork (TM) Movement in Humans:
Characterization by Phase-sensitive OCT
(PhS-OCT). Murray A. Johnstone2, P. Li1, T. T.
Shen1, 2, R. K. Wang1. 1Bioengineering, University
of Washington, Seattle, WA; 2Ophthalmology,
University of Washington, Seattle, WA *CR
6C
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Retina
403 Retinitis Pigmentosa II
Moderators: Yasuhiro Ikeda and David J. Wilson
4016 — 8:30 Long-term efficacy and safety of
treatment of retinitis pigmentosa with valproic
acid. Christine N. Kay, S. Bhalla. Ophthalmology,
University of Florida, Gainesville, FL
4017 — 8:45 Visual Function Improvements
following Electroacupuncture for Retinitis
Pigmentosa. Ava K. Bittner1, J. Gould3, C.
Rozanski1, A. Rosenfarb2, M. R. DeJong3, A.
Benavente-Perez4, G. Dagnelie1. 1Ophthalmology,
Johns Hopkins University, Baltimore, MD;
2
Acupuncture Health Associates, Westfield, NJ;
3
Johns Hopkins University, Baltimore, MD; 4SUNY
College of Optometry, New York, NY f
4018 — 9:00 Evaluation of peripheral retinal
vasculitis in retinitis pigmentosa using wide-field
fluorescein angiography. Matthew B. Kaufman1, 2,
C. A. Medina-Mendez1, 2, T. R. Friberg1, 2, A. W.
Eller1, 2. 1Ophthalmology, UPMC Eye Center,
Pittsburgh, PA; 2Ophthalmology, University of
Pittsburgh School of Medicine, Pittsburgh, PA *CR
4019 — 9:15 Inheritance of Retinitis
Pigmentosa: Update in the Era of Genetic
Testing. Kari E. Branham, J. Huang, K. T.
Jayasundera, J. R. Heckenlively. Ophthalmology
and Visual Sciences, University of Michigan, Ann
Arbor, MI *CR
4020 — 9:30 Ultra wide-field autofluorescence
is useful to evauluate residual retinal functions
in patients with Retinitis Pigmentosa. Shuntaro
Ogura, T. Yasukawa, M. Yoshida, Y. Ogura.
Department of Ophthalmology, Nagoya City Univ
Medical School, Nagoya, Japan
4021 — 9:45 Recombinant Human Nerve
Growth Factor Protects Photoreceptor
Degeneration in a Rat Model of Inherited
Retinitis Pigmentosa. Luigi Aloe1, P. Bianchi1,
M. Rocco1, A. Micera2, A. Lambiase3, S. Bonini3.
1
Institute of Neurobiology and Molecular Medicine,
National Research Council, Rome, Italy; 2G.B.
Bietti IRCCS, Rome, Italy; 3Department of
Ophthalmology, University of Rome, Campus
Biomedico, Rome, Italy *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
269
Wednesday Papers/
Minisymposium
8:30 am – 10:15 am
4005 — 9:15 PGC-1alpha Signaling Regulates
Retinal Ganglion Cell Injury Responses And
Atrocyte Reactivity. Jeremy M. Sivak1, 2, X. Guo1,
S. Dason2, A. Nahirny1. 1Vision Sciences, Toronto
Western Hospital, University Health Network,
Toronto, ON, Canada; 2Ophthalmology and Vision
Sciences, University of Toronto, Toronto, ON,
Canada
402 New Ideas
4015 — 10:00 A quantitative approach to the
analysis of visual field defect location and its
relationship to measures of disability. Michael V.
Boland, P. Y. Ramulu, K. S. Arora, J. L. Jefferys, D.
S. Friedman. Wilmer Eye Institute, Johns Hopkins
University, Baltimore, MD *CR
4022 – 4039 – Wednesday – Papers/Minisymposium
4022 — 10:00 Nonsyndromic RP Due to BBS2
Mutations. Meghan J. Marino1, G. J. Pauer1,
J. Chiang3, S. A. Hagstrom1, 2, E. I. Traboulsi1, 2.
1
Ophthalmic Research, Cole Eye Institute,
Cleveland Clinic, Cleveland, OH; 2Ophthalmology,
Cleveland Clinic Lerner College of Medicine Case
Western Reserve University, Cleveland, OH; 3Casey
Eye Institute Molecular Diagnostics Laboratory,
Portland, OR *CR
6E
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Retina
404 DR: Therapeutic Effects
Moderator: Peter A. Campochiaro
Wednesday Papers/
Minisymposium
8:30 am – 10:15 am
4023 — 8:30 Intravitreal ranibizumab (RBZ)
suppresses posterior retinal nonperfusion (RNP)
in patients with diabetic macular edema (DME).
Peter A. Campochiaro1, C. Wykoff2, D. Chen3, H.
Shapiro4, J. S. Ehrlich5, R. Rubio6. 1Ophthalmology
and Neuroscience, Johns Hopkins Wilmer Eye
Inst, Baltimore, MD; 2Retina Consultants of
Houston, Houston, TX; 3Genentech, Inc., South
San Francisco, CA; 4Genentech, Inc., South
San Francisco, CA; 5Genentech, Inc., South San
Francisco, CA; 6Genentech, Inc., South San
Francisco, CA *CR, f
4024 — 8:45 Intensive Diabetes Therapy
Reduces Ocular Surgeries in Patients with
Type 1 Diabetes: twenty-eight year followup of
the Diabetes Control and Complications Trial
/ Epidemiology of Diabetes Interventions and
Complications study (DCCT/EDIC). Lloyd P.
Aiello1, 2, W. Sun5, P. A. Cleary5, J. M. Lachin5,
S. Gangaputra3, R. Klein4, A. Das7, S. Kiss6, A.
Domalpally3, R. P. Danis3. 1Beetham Eye Institute,
Joslin Diabetes Center, Boston, MA; 2Department
of Ophthalmology, Harvard Medical School,
Boston, MA; 3Fundus Photograph Reading Center,
University of Wisconsin, Madison, WI; 4Department
of Ophthalmology and Visual Sciences, University
of Wisconsin School of Medicine and Public
Health, Madison, WI; 5Biostatistics Center, George
Washington University, Rockville, MD; 6Clinical
Research, Weill Cornell Medical College, New
York, NY; 7University of New Mexico School of
Medicine, Albuquerque, NM *CR, f
4025 — 9:00 Canadian PhIIIb study:
ranibizumab combination/monotherapy in visual
impairment due to DME: Preliminary Analysis.
Thomas Sheidow1, 2, A. R. Berger3, F. deTakacsy4,
R. Li4, B. Rehel5, A. Courseau4. 1Ivey Eye Institute,
London, ON, Canada; 2Ophthalmology, Western
University, London, ON, Canada; 3St. Michael’s
Hospital, Toronto, ON, Canada; 4Novartis
Pharmaceuticals Canada Inc., Dorval, QC, Canada;
5
Everest Clinical Research Services, Inc., Markham,
ON, Canada *CR, f
4026 — 9:15 Baseline Predictors of
improvement in self-reported visual function
following treatment with ranibizumab in patients
with diabetic macular edema. Rohit Varma1, N.
M. Bressler2, C. Dolan3, L. Yau3, J. F. Ward3, S.
Colman3. 1Ophthalmology and Visual Sciences,
University of Illinois at Chicago Eye and Ear
Infirmary, Chicago, IL; 2Retina Division, Wilmer
Eye Institute, Johns Hopkins University School of
Medicine, Baltimore, MD; 3Genentech, Inc., South
San Francisco, CA *CR, f
4033 — 9:40 Pathogenesis of Herpes
Stromal Keratitis - A Focus on Corneal
Neovascularization. Barry T. Rouse. Pathobiology,
Univ of Tennessee Coll of Vet Med, Knoxville, TN
4027 — 9:30 Effect of Statins and Diabetes
Therapy (Oral Hypoglycemics and Insulin)
on the Outcomes of Patients Treated with
Ranibizumab and/or Laser Therapy. Mohammad
A. Sadiq1, M. Hassan1, Y. J. Sepah1, G. K. Loh2, 1, S.
Kherani1, M. Hanout1, R. E. Annam1, M. Ansari1,
D. V. Do1, Q. Nguyen1. 1Retinal Imaging Research
and Reading Center, Wilmer Eye Institute. Johns
Hopkins University, Baltimore, MD; 2Division
of medicine, University College London Medical
School, London, United Kingdom *CR, f
Wednesday, May 08, 2013 8:30 AM-10:15 AM
4028 — 9:45 Effects of Intravitreal
Ranibizumab on Diabetic Retinopathy Severity:
36 Month Data from the RISE and RIDE Phase
III Trials. Jason S. Ehrlich1, A. Domalpally2,
L. Yau1, J. J. Hopkins1, M. S. Ip2. 1Genentech,
Inc, South San Francisco, CA; 2Department of
Ophthalmology and Visual Sciences, University of
Wisconsin Medical School, Madison, WI *CR, f
4029 — 10:00 RELIGHT - Ranibizumab
treatment of diabetic macular oedema with
bimonthly monitoring after a phase of initial
Treatment. Ian A. Pearce. Royal Liverpool
University Hospital, St Paul’s Eye Unit, Liverpool,
United Kingdom *CR, f
606/607
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Immunology/Microbiology / Cornea
405 Host Responses to Ocular
Herpesvirus Infection - What Have
We Learned and What Is the Future
Direction? - Minisymposium
This session will cover current data and concepts
from clinical presentation, immune response/
regulation to virus infection, and development of
novel treatment strategies.
Moderators: Daniel J. Carr and Barry T. Rouse
4030 — 8:30 Insights into Natural History
of HSV Infections in the Era of Changing
Epidemiology. Anna Wald. University of
Washington, Seattle, WA *CR
4031 — 9:00 Herpes Simplex Virus Evasion of
Host Immunity and the Autophagy Response.
David A. Leib. Microbiology and Immunology HB
7556, Dartmouth Medical School, Lebanon, NH
4032 — 9:20 Chronic Murine Cytomegalovirus
Infection results in more severe Experimental
Choroidal Neovascularization. Richard D. Dix.
Department of Biology, Georgia State University,
Atlanta, GA
4034 — 10:00 Discussion. Todd P. Margolis.
UCSF Proctor Foundation, Univ of California-San
Francisco, San Francisco, CA *CR
608
Anatomy/Pathology
406 Myopia and Emmetropization
Moderators: Frank Schaeffel and Chi-ho To
4035 — 8:30 Distribution and Determinants
of Eye Size and Shape in Newborn Children:
a Magnetic Resonance Imaging Analysis.
Laurence S. Lim1, 2, P. Tan2, G. Chong2, Y. Chong2,
M. V. Fortier3, P. Gluckman4, 5, S. Saw2, 1, A. Qiu2.
1
Ophthalmology, Singapore National Eye Center,
Singapore, Singapore; 2National University of
Singapore, Singapore, Singapore; 3KK Women’s
and Children’s Hospital, Singapore, Singapore;
4
Singapore Institute for Clinical Sciences, the
Agency for Science, Technology and Research,
Singapore, Singapore; 5Liggins Institute, University
of Auckland, Auckland, New Zealand *CR
4036 — 8:45 Central retinal thickness and
axial length in the Copenhagen Child Cohort
2000 study: data from 432 11-year-old children.
Xiao Q. Li1, M. Larsen1, I. C. Munch2. 1Department
of Ophthalmology, Glostrup Hospital, Glostrup,
Denmark; 2Department of Ophthalmology, Roskilde
Hospital, Roskilde, Denmark
4037 — 9:00 Neurochemical Ablation of
Peripheral Glucagonergic Amacrine Cells in
the Chick Retina and its Effects on Axial Eye
Growth and Refractive Error. Diane Nava1, 2, A.
Chang2, L. A. Ostrin2, Z. Chen2, 3, C. F. Wildsoet1, 2.
1
Vision Science Group, UC Berkeley, Berkeley,
CA; 2Center for Eye Disease and Development,
UC Berkeley School of Optometry, Berkeley, CA;
3
Department of Opthalmology and Vision Science,
Fudan University Eye and ENT Hospital, Shanghai,
China
4038 — 9:15 Ocular growth guided by dual
focal fresnel lenses requires an intact optic
nerve. Sally A. McFadden1, D. Y. Tse2, C. To2, C.
F. Wildsoet3. 1School of Psychology, University of
Newcastle, Callaghan, NSW, Australia; 2School of
Optometry, The Hong Kong Polytechnic University,
Kowloon, Hong Kong; 3School of Optometry,
University of California, Berkeley, CA
4039 — 9:30 Effects of Long-WavelengthPass Filters on Refractive Development in
Rhesus Monkeys. Earl L. Smith1, 2, L. Hung1, 2,
B. Arumugam1, 2, J. Huang1, 2, M. Neitz3, J. Neitz3.
1
College of Optometry, University of Houston,
Houston, TX; 2Vision Cooperative Research
Centre, Sydney, NSW, Australia; 3Department of
Ophthalmology, University of Washington Medical
School, Seattle, WA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
270
Wednesday – Papers/Minisymposium – 4040 – 4059
4040 — 9:45 The role of central retina in
chicks during form deprivation myopia. Jianchao
Wang1, 2, R. Chun1, K. Li1, Q. Liu1, 2, C. To1, 2.
1
Laboratory of Experimental Optometry, Centre
for Myopia Research, School of Optometry, The
Hong Kong Polytechnic University, HongKong,
China; 2State Key Laboratory of Ophthalmology,
Zhongshan Ophthalmic Centre, Sun Yat-sen
University, Guangzhou, China
4041 — 10:00 Photoreceptor Outer Retinal
Function as the Primary Controller of Ocular
Growth. David P. Crewther1, 2, S. N. Kiely2, M.
J. Murphy2, N. Riddell2, S. G. Crewther2. 1Centre
for Human Psychopharmacology, Swinburne
Univ of Technology, Melbourne, VIC, Australia;
2
Psychological Science, La Trobe University,
Melbourne, VIC, Australia
609
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Lens
407 Cell Biology Impacts
Lens Function
Moderators: Marc Kantorow and A S. Menko
4043 — 8:45 Autophagy mediates
mitochondrial degradation in the developing
and adult eye lens. Marc Kantorow1, D. Chauss1,
A. Mohamed2, K. Gilliland3, L. A. Brennan1, M. J.
Costello3. 1Biomedical Sciences, Florida Atlantic
University, Boca Raton, FL; 2L. V. Prasad Eye
Institute, Hydrabad, India; 3Cell Biology and
Physiology, University of North Carolina, Chapel
Hill, NC
4044 — 9:00 Loss of Pten Rescues Akt
Phosphorylation, Apoptosis and Size in Fgfr2
Deficient Lenses. Blake R. Chaffee, M. R. Leonard,
B. D. Wagner, M. L. Robinson. Zoology, Miami
University, Oxford, OH
4045 — 9:15 Role of Birc7 in the Mouse Lens.
Alicia De Maria, S. Bassnett. Ophthalmology and
Visual Sciences, Washington University, St Louis,
MO
4046 — 9:30 The Optical Quality of InhibitorTreated Avian Crystalline Lenses. Gah-Jone
Won, V. Choh. School of Optometry, University of
Waterloo, Waterloo, ON, Canada
611-614
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
408 Differentiation of Stem and
iPS Cells
Moderators: Jason S. Meyer and G Astrid Limb
4049 — 8:30 MITF regulation of early cell fate
in a human embryonic stem cell model of retinal
development. Elizabeth E. Capowski1, J. Simonett1,
E. Clark1, L. S. Wright1, I. Pinilla Lozano2, 3, J.
Phillips1, K. Wallace1, D. M. Gamm4, 5. 1Waisman
Center, University of Wisconsin-Madison, Madison,
WI; 2Ophthamology, University Hospital Lozano
Blesa, Zaragoza, Spain; 3IIS Aragon, Aragon Health
Sciences Institute, Zaragoza, Spain; 4Ophthamology
and Visual Sciences, University of WisconsinMadison, Madison, WI; 5McPherson Eye Research
Institute, University of Wisconsin-Madison,
Madison, WI *CR
4050 — 8:45 Simplified and Efficient
Generation of Photoreceptors from Human
Pleuripotent Stem Cells. Joo Young Shin, H. Yu.
Ophthalmology, Seoul National University, Seoul,
Republic of Korea
4051 — 9:00 Improving Human RPE
Differentiation from iPS Cells: Lessons from
Mouse Eye Development. Kapil Bharti1, J.
Davis1, B. Corneo2, Q. Wan1, K. J. Miyagishima1,
S. Temple2, S. S. Miller1. 1NEI, National Institutes
of Health, Bethesda, MD; 2National Eye Institute,
National Institutes of Health, Bethesda, MD *CR
4052 — 9:15 Investigating the role of VSX2
(CHX10) in human retinogenesis using iPS cells.
Joe Phillips1, 2, E. Perez1, K. Wallace1, J. M. Martin1,
R. Singh1, E. E. Capowski1, L. S. Wright1, E. Clark1,
E. F. Percin3, D. M. Gamm1, 2. 1Waisman Center,
University of Wisconsin, Madison, WI; 2McPherson
Eye Research Institute, University of Wisconsin,
Madison, WI; 3Medical Genetics, Gazi University,
Ankara, Turkey *CR
4053 — 9:30 Differentiation of Human
Protein Induced Pluripotent Stem Cells (piPS)
Towards a Retinal Pigment Epithelium (RPE)
Fate. Jie Gong, M. A. Fields, L. V. Del Priore.
Ophthalmology, MUSC Storm Eye Institute,
Charleston, SC
4054 — 9:45 Investigating the pathophysiology
of USH2A associated retinal degeneration with
patient specific iPSCs. Budd A. Tucker1, R. F.
Mullins1, K. R. Anfinson1, L. M. Affatigato1, J.
A. Halder1, P. M. Brzeskiewicz1, E. M. Stone1, 2.
1
Ophthalmology, Inst for Vision Rsrch, Univ of
Iowa, Iowa City, IA; 2HHMI Investigator, Iowa
City, IA *CR
4055 — 10:00 Differentiation of iPS-RPE
cells from a patient with clinical anophthalmia.
Amanda-Jayne F. Carr1, L. Ho2, L. Chen1, G. Selva
Raj2, A. A. Vugler1, M. A. Shboul2, A. Colman2,
B. Reversade2, P. J. Coffey1. 1Division of ORBIT,
Institute of Ophthalmology, University College
London, London, United Kingdom; 2Dept. of
Paediatrics, A*STAR Institute of Medical Biology,
Biopolis, Singapore
618-620
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Physiology/Pharmacology / Cornea /
Retinal Cell Biology
409 Purine Signaling in the Eye: Role
in Health and Disease - Minisymposium
The field of purine signaling is rapidly expanding,
with a great diversity of roles in health and
disease. Purine receptors (P1 Adenosine and P2
Purine/Nucleotide receptors) have been identified
throughout the tissues of the eye with proposed
roles in processes including control of intraocular
pressure, visual processing and mediation of
inflammatory responses. This symposium explores
purine signaling in ocular tissues: lacrimal gland,
trabecular meshwork, lens and retina. Questions
are asked about the role of purine signaling in
healthy ocular tissue, including in development
and in retinal processing, as well as addressing the
consequences of dysregulation to ocular health in
disease, including dry eye and glaucoma. Purine
receptors as putative drug targets for ocular disease
are also discussed.
Moderators: Julie Sanderson, Claire H. Mitchell
and Claudio Bucolo
4056 — 8:30 Introduction to Purine Signaling.
Julie Sanderson. School of Pharmacy, University of
East Anglia, Norwich, United Kingdom
4057 — 8:45 Purine Signaling in the
Trabecular Meshwork: A Regulator of
Intraocular Pressure. Mortimer M. Civan.
Physiology-Richards Bldg, Univ of Pennsylvania
Sch of Med, Philadelphia, PA
4058 — 9:00 Purinergic Receptors in Lacrimal
Gland Health and Dry Eye Disease. Darlene A.
Dartt. Schepens Eye Research Institute, Boston,
MA
4059 — 9:15 TRPV4 and Hemichannels
Cooperate to Play a Critical Role in Purine
Signaling in the Lens. Nicholas A. Delamere.
Physiology, University of Arizona, Tucson, AZ
4047 — 9:45 Estimation of Ciliary Muscle
Forces Required to Induce Corneal Deformation.
Robert P. Wilkes, M. A. Reilly. Biomedical
Engineering, University of Texas at San Antonio,
San Antonio, TX
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
271
Wednesday Papers/
Minisymposium
8:30 am – 10:15 am
4042 — 8:30 JNK inactivation suppresses
mTOR (Mammalian Target of Rapamycin)
pathway to induce loss of nuclei and organelles
in the lens through Autophagy. Subhasree Basu1,
S. Rajakaruna1, B. A. Reyes2, E. J. Van Bockstaele2,
A. S. Menko1, 3. 1Pathology Anatomy & Cell
Biology, Thomas Jefferson University, Philadelphia,
PA; 2Neuroscience, Thomas Jefferson University,
Philadelphia, PA; 3Wills Vision Research Center at
Jefferson, Philadelphia, PA
4048 — 10:00 Linking the optical properties of
the lens to its cellular physiology: a multimodal
imaging and modelling approach. Ehsan Vaghefi
Rezaei1, A. Kim1, P. J. Donaldson2, 1. 1Department
of Optometry and Vision Sciences, University
of Auckland, Auckland, New Zealand; 2School
of Medical Sciences, University of Auckland,
Auckland, New Zealand
4060 – 4080 – Wednesday – Papers/Minisymposium
4060 — 9:30 Purine Signaling in Müller
Cells During Development and in the Adult
Retina in Health and Disease. Antje Grosche.
Pathophysiology of Neuroglia, University of
Leipzig, Leipzig, Germany
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Cornea
4061 — 9:45 Purinergic Signaling in Retinal
Processing. Thomas E. Salt. Visual Neuroscience,
UCL Institute of Ophthalmology, London, United
Kingdom *CR
411 Keratoconus and Biomechanics
4062 — 10:00 Purines and Low Grade
Inflammation at Either End of the Retina; ATP
and Cytokines in Both RGCs and RPE. Claire H.
Mitchell. Anatomy and Cell Biology, University of
Pennsylvania Library, Philadelphia, PA *CR
4069 — 8:30 Mutations in the zinc finger
protein gene, ZNF469 contribute to the
pathogenesis of keratoconus. Andrea L. Vincent1, 2,
C. Jordan1, 2, B. Hay1, A. J. Richards1, C. N.
McGhee1, 2. 1Ophthalmology, New Zealand National
Eye Centre, University of Auckland, Auckland,
New Zealand; 2Eye Department, Greenlane Clinical
Centre, Auckland District Health Board, Auckland,
New Zealand *CR
TCC LL 4/5
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics
410 Spatial Vision, Visual
Psychophysics and Aging II
Moderators: Joanne M. Wood and Heidi J. Hofer
4063 — 8:30 Two-point detection and
appearance in the absence of higher order
aberrations. Heidi J. Hofer, D. E. Koenig. College
of Optometry, University of Houston, Houston, TX
4064 — 8:45 A Comparison of Acuity and
Cone Density in the Temporal Retina. Nancy J.
Coletta1, T. Y. Chui2, A. E. Elsner2. 1Vision Science,
New England College of Optometry, Boston,
MA; 2School of Optometry, Indiana University,
Bloomington, IN *CR
Wednesday Papers/
Minisymposium
8:30 am – 10:15 am
TCC 303
4065 — 9:00 Age-related variation in foveal,
parafoveal and peripheral spatial suppression.
Rigmor C. Baraas, C. Aaen-Stockdale, S. J. Gilson.
Optometry & Visual Science, Buskerud University
College, Kongsberg, Norway
4066 — 9:15 Heterochromatic Modulation
Photometry can be used to measure Macular
Pigment Optical Density. Cord R. Huchzermeyer1,
J. Schlomberg1, U. Welge-Lüssen1, T. Berendschot2,
J. J. Kremers1. 1Department of Ophthalmology,
University Erlangen-Nuremberg, Erlangen,
Germany; 2University Eye Clinic, Maastricht,
Netherlands
4067 — 9:30 Comparability of Visual
Performance of Individuals with Low Vision in
Real and Virtual Street Intersections. Lei Liu,
E. L. Bowman. School of Optometry, University of
Alabama at Birmingham, Birmingham, AL
4068 — 9:45 Optical quality and subjective
judgments of blur under pure simultaneous
vision. Carlos Dorronsoro, A. Radhakrishnan, L.
Sawides, S. Marcos. Instituto de Optica, CSIC,
Madrid, Spain *CR
Moderator: Shukti Chakravarti
4070 — 8:45 Matrix Metalloproteinase-9 drives
disease progression of Keratoconus. Ashwini
Ranganath, R. Shetty, S. D’Souza, K. Wadia, D.
Das, A. Ghosh. cornea and refractive surgery,
Narayana Nethralaya eye hospital, Bangalore, India
f
4071 — 9:00 Novel proteins and metabolites
for the identification of Keratoconus disease.
Dimitrios Karamichos1, 2, J. Hjortdal4, A. E.
Hutcheon1, 2, J. M. Asara3, J. D. Zieske1, 2.
1
Schepens Eye Research Institute/MEE, Boston,
MA; 2Department of Ophthalmology, Harvard
Medical School, Boston, MA; 3Division of
Signal Transduction/Mass Spectrometry Core,
Beth Israel Deaconess Medical Center, Harvard
Medical School, Boston, MA; 4Department of
Ophthalmology, Aarhus University Hospital, Aarhus
C, Denmark *CR
4072 — 9:15 Evaluation of transcorneal
iontophoresis of riboflavin for corneal
collagen cross-linking. Alejandro Arboleda1, 2, L.
Kowalczuk3, M. Savoldelli4, C. Klein3, S. Ladraa3,
J. A. Parel1, 4, F. F. Behar-Cohen3, 4. 1Ophthalmic
Biophysics Center, Dept. of Ophthalmology,
Bascom Palmer Eye Institute, University of
Miami Miller School of Medicine, Miami, FL;
2
Dept. of Biomedical Engineering, University
of Miami College of Engineering, Coral Gables,
FL; 3INSERM UMRS872: Physiopathology of
Ocular Diseases: Therapeutic Innovations, Centre
de Recherche des Cordeliers, Pierre et Marie
Curie University, Paris Descartes University,
Paris, France; 4AP-HP Hôtel-Dieu, Dept. of
Ophthalmology, Sorbonne Paris Cité, Paris
Descartes University, Faculty of Medicine, Paris,
France *CR
4073 — 9:30 Corneal biomechanical
properties in corneal collagen cross-linking
(CXL) at high fluences. Arthur Hammer1, O.
Richoz1, D. Tabibian1, F. Hoogewoud1, F. Hafezi1, 2.
1
Ophthalmology, Geneva University Hospitals,
Geneva, Switzerland; 2Ophthalmology, Doheny
Eye Institute, Keck school of medicine USC, Los
Angeles, CA *CR
4074 — 9:45 Soluble collagen protects the
corneal fibrils during riboflavin crosslinking.
Marcos Garza-Madrid1, 2, J. Elisseeff1.
1
Translational Tissue Engineering Center, Wilmer
Eye Institute, Johns Hopkins School of Medicine,
Baltimore, MD; 2Ophthalmology and Visual
Sciences Research Chair, School of Medicine
and Health Sciences, Tecnológico de Monterrey,
Monterrey, Mexico *CR
4075 — 10:00 Brillouin microscopy of
collagen crosslinking: non-contact depthdependent analysis of corneal elastic modulus.
Giuliano Scarcelli1, S. Kling2, E. Quijano1, R.
Pineda3, S. Marcos2, S. H. Yun1. 1Wellman Center
for Photomedicine, Harvard Medical School,
Cambridge, MA; 2Instituto de Optica, Conjejo
Superior de investigation cientifica, Madrid, Spain;
3
Ophthalmology, Mass eye and ear Infirmary,
Boston, MA *CR
TCC 304
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Visual Neuroscience
412 Photoreceptors: Structure,
Transduction, Signaling
Moderators: Marie E. Burns and Wolfgang Baehr
4076 — 8:30 Modulating the phototransduction
cascade with small molecules. Tomoki Isayama1,
J. Wu1, S. Miyazono1, V. Lee1, E. S. Levine1, E.
Makino3, A. L. Zimmerman2, C. L. Makino1.
1
Ophthalmology, Mass Eye & Ear Infirmary,
Boston, MA; 2Molecular Pharmacology, Physiology
and Biotechnology, Brown University, Providence,
RI; 3LGCR, Sanofi Corporation, Waltham, MA
4077 — 8:45 Under-expression of GAP
proteins: Effect on Mouse Rod Response Decay.
Gordon L. Fain1, 2, M. L. Woodruff1, C. J. Chen3.
1
Integrative Biology and Physiology, Univ of
California-Los Angeles, Los Angeles, CA; 2Jules
Stein Eye Institute, UCLA, Los Angeles, CA;
3
Biochemistry and Molecular Biology, Virginia
Commonwealth University, Richmond, VA
4078 — 9:00 Light-induced translocation
of RGS9-1 and Gβ5L in Mouse Rod
Photoreceptors. You-Wei Peng1, M. Tian1, M. L.
Zallocchi1, W. Wang1, C. J. Chen2, K. Palczewski3,
D. E. Cosgrove1. 1Genetics, Boys Town Natl
Research Hosp, Omaha, NE; 2Biochemistry &
Molecular Biology, Virginia Commonwealth
University, Richmond, VA; 3Pharmacology, Case
Western Reserve University, Cleveland, OH *CR
4079 — 9:15 Complete protein composition of
the photoreceptor disc identified by label-free
quantitative proteomics. Nikolai P. Skiba, V. Y.
Arshavsky. Duke University, Durham, NC
4080 — 9:30 Molecular Function of
Peripherin-2/rds for Photoreceptor Membrane
Structure. Andrew F. Goldberg, N. Khattree, L. M.
Ritter. Eye Research Institute, Oakland University,
Rochester Hills, MI
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
272
Wednesday – Papers/Minisymposium – 4081 – 4082
4081 — 9:45 Bleach-Induced Desensitization
and Response Compression of the Photocurrent
and Photovoltage in Mouse Rods. Johan
Pahlberg1, R. Frederiksen2, K. J. Miyagishima1, S.
Nymark2, A. P. Sampath1, M. C. Cornwall2. 1Zilkha
Neurogenetic Institute, University of Southern
California, Los Angeles, CA; 2Boston University
Medical School, Department of Physiology and
Biophysics, Boston, MA
4082 — 10:00 Phosphoinositides and
membrane trafficking in zebrafish cone inner
segments. Sara Hayden, S. E. Brockerhoff.
Biochemistry, University of Washinton, Seattle, WA
Wednesday Papers/
Minisymposium
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
273
4083 – 4105 – Wednesday – Posters
Exhibit Hall A0001-A0047
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Retina
413 AMD II, RE
Moderators: David R. Hinton and Diana V. Do
4083 — A0001 Pars Plana Vitrectomy,
Subretinal Injection of Recombinant Tissue
Plasminogen Activator and Intraocular Gas
Tamponade for Thick Submacular Hemorrhage
with Polypoidal Choroidal Vasculopathy.
Woohyok Chang, C. Cho, M. Sagong, H. Oh, J.
Park, D. Park, M. Kim, W. Gu, J. Son. Department
of Ophthalmology, Yeungnam Univ College of
Medicine, Daegu, Republic of Korea
Wednesday Posters
8:30 am – 10:15 am
4084 — A0002 The Effects of Docosahexaenoic
Acid (DHA) Dietary Supplementation on Retinal
Lipid Profile in a Mouse Model of Stargardt-like
Macular Dystrophy (STGD3). Mandy Hong1, S.
Kuny1, R. Bryant1, F. Gaillard1, M. Suh2, Y. Sauve1.
1
Ophthalmology, University of Alberta, Edmonton,
AB, Canada; 2Human Nutritional Sciences,
University of Manitoba, Winnipeg, MB, Canada
4085 — A0003 In vivo Evaluation of Surface
Modified Expanded-polytetrafluroethylene
(ePTFE) Substrate as a Permanent Substrate
for Cell Transplantation. Shen Nian1, Z. Fu1, C.
M. Sheridan3, V. Kearns3, R. Williams3, S. Wong1,
K. Vasilev4, A. Bachhuka4, A. C. Lo1, 2, W. W. Lai1.
1
Ophthalmology, University of Hong Kong, Hong
Kong, Hong Kong; 2Research Centre of Heart,
Brain, Hormone and Healthy Aging, University of
Hong Kong, Hong Kong, Hong Kong; 3Eye and
Vision Science, University of Liverpool, Liverpool,
United Kingdom; 4Mawson Institute and School
of Advanced Manufacturing, University of South
Australia, Mawson Lakes, SA, Australia
4090 — A0008 Ranibizumab Leads to
Regression or Elimination of Choroidal
Neovascular Membranes in Most Eyes with
AMD: A HARBOR Subanalysis. Nikolas J.
London1, P. E. Tornambe1, L. Yau2, J. A. Nau2, L.
Tuomi2. 1Retina Consultants San Diego, San Diego,
CA; 2Genentech Inc., South San Francisco, CA
*CR, f
4091 — A0009 Anti-VEGF Gene Therapy for
Wet AMD: Phase I/II Safety and Pharmacology
Results. Elizabeth P. Rakoczy1, 2, M. Lai1, 2,
C. Pierce2, A. L. Magno2, R. Samulski3, T. W.
Chalberg4, M. S. Blumenkranz5, I. Constable1, 2.
1
Centre for Ophthalmology and Visual Sciences,
The University of Western Australia, Perth, WA,
Australia; 2Molecular Ophthalmology, Lions Eye
Institute, Perth, WA, Australia; 3Gene Therapy
Centre, University of North Carolina, Chapel Hill,
NC; 4Avalanche Biotechnologies, San Francisco,
CA; 5Byers Eye Institute at Stanford, Palo Alto, CA
*CR, f
4092 — A0010 Polypoidal choroidal
vasculopathy in Caucasian patients. Stephen
Davis, A. Lauer, C. J. Flaxel. Oregon Health and
Science University, Casey Eye Institute, Portland,
OR *CR
4093 — A0011 Baseline characteristics and
response to intravitreal ranibizumab therapy for
age-related macular degeneration. Misa Suzuki,
N. Nagai, K. Izumi-Nagai, H. Shinoda, T. Koto,
A. Uchida, H. Mochimaru, K. Yuki, K. Tsubota, Y.
Ozawa. Ophthalmology, Keio University School of
Medicine, Tokyo, Japan *CR, f
4094 — A0012 Disease Activity in Disciform
Scars due to Age-Related Macular Degeneration
(AMD). Deborah Witkin1, J. B. Sanderson1, D.
Ferrara2, 1, E. Reichel1. 1Ophthalmology, Tufts
Medical Center, Boston, MA; 2Digital Angiography
Reading Center DARC, Great Neck, NY *CR
4087 — A0005 Autofluorescence and OCT of
Retinal pigment epithelial tears. Naoto Hanyuda,
T. Sato, R. Mukai, S. Kishi. Gunma University,
Maebashi, Japan *CR
4095 — A0013 The Incidence of Neovascular
Subtypes in Newly Diagnosed Wet Age-Related
Macular Degeneration. Jesse J. Jung1, 3, L.
Xu2, 5, R. Gallego-Pinazo2, 4, S. Mrejen2, 3, M.
Marsiglia2, 3, S. Boddu1, K. Freund1, 2. 1Department
of Ophthalmology, New York Univ School of
Med, New York, NY; 2Vitreous Retina Macula
Consultants of New York, New York, NY; 3LuEsther
T. Mertz Retinal Research Center, Manhattan
Eye, Ear, and Throat Hospital, New York, NY;
4
Department of Ophthalmology, University and
Polytechnic Hospital La Fe, Valencia, Spain; 5St.
Vincent’s Medical Center, Bridgeport, CT *CR
4088 — A0006 Anatomic patterns and clinical
presentation of recurrence in ‘stable’ wet Age
Related Macular Degeneration (AMD) patients.
Fani Zacharaki, M. N. Chandran, N. Nair, P.
Vijayakumar, G. Menon. Frimley Park Hospital
NHS Foundation Trust, Frimley, United Kingdom
*CR
4096 — A0014 Choroidal thickness change
following intravitreal bevacizumab therapy
for wet age-related macular degeneration: Six
months results. Sharif Y. El Emam, G. Barteselli, J.
Chhablani, S. Lee, I. Kozak, L. Cheng, W. Freeman.
Ophthalmology, Shiley Eye Center, UCSD, La
Jolla, CA *CR
4089 — A0007 Detection and Quantification
of Autofluorescence Abnormalities in Patients
with Neovascular Macular Degeneration using
a Fully Automated Image Analysis Algorithm.
Kathryn L. Pepple, Q. Nie, S. S. Ong, S. W. Cousins.
Ophthalmology, Duke Eye Center, Durham, NC
*CR
4097 — A0015 The Relationship of Choroidal
Thickness to Scotopic Sensitivity in Agerelated Macular Degeneration (AMD). Karl G.
Csaky1, 3, D. G. Birch1, 2, R. Gelman1, J. Felius1.
1
Ophthalmology, Retina Foundation of the
Southwest, Dallas, TX; 2Ophthalmology, University
of Texas Southwestern Medical Center, Dallas, TX;
3
Texas Retina Associates, Dallas, TX *CR
4086 — A0004 Prevalence of Subretinal
Drusenoid Deposits in Age-Related Macular
Degeneration with Newly Diagnosed Choroidal
Neovascularization. Sandrine A. Zweifel, R. A.
Rieder, M. M. Kohler, R. Gambon. Department of
Ophthalmology, University Hospital Zurich, Zurich,
Switzerland
4098 — A0016 Choroidal Thickness
following Anti-Vascular Endothelial Growth
Factor Therapy for Neovascular Age-Related
Macular Degeneration. Charlotte So, Z. Ravage.
Ophthalmology, Rush University Medical Center,
Chicago, IL
4099 — A0017 Correlation Between Changes
in Subfoveal Choroidal Thickness and 1-Year
Outcomes of Ranibizumab Therapy for
Polypoidal Choroidal Vasculopathy. Taiichi
Hikichi, H. Kitamei, S. Shioya, M. Higuchi, T.
Matsushita, S. Kosaka, R. Matsushita, K. Takami,
H. Ohtsuka. Ohtsuka Eye Hospital, Sapporo, Japan
4100 — A0018 Axial Length and Subfoveal
Choroidal Thickness in Individuals with Agerelated Macular Degeneration (AMD). Chih
Ping Wang1, 2, C. Lai1, 2, J. Huang1, 2, C. Kuo1, 2.
1
Department of Ophthalmology, Chang Gung
Memorial Hospital, Chiayi, Chiayi County, Taiwan;
2
Chang Gung University, Taoyan, Taiwan
4101 — A0019 APE1/Ref-1 redox inhibitor
APX3330 modulates choroidal endothelial cells
by transcriptional regulation of NF-κB and
STAT3 activity. Xiaoxi Qiao1, Y. Li1, X. Liu1, T.
Zhou1, M. R. Kelley2, P. A. Edwards1, H. Gao1.
1
Ophthalmology, Henry Ford Health System,
Detroit, MI; 2Herman B Wells Center for Pediatric
Research, Indiana University School of Medicine,
Indianapolis, IN *CR
4102 — A0020 Apolipoprotein mimetic Dual
Domain Peptide reduces Neutral Lipid Deposits
in murine Bruch’s Membrane. Armin Mohi, S.
Grisanti, M. Rudolf. Department of Ophthalmology,
University of Luebeck, Luebeck, Germany *CR
4103 — A0021 Identification of Human
Macular Tissue Antigens Recognized by Serum
Auto-Antibodies (auto-Abs) in Patients with
Age-Related Macular Degeneration (AMD).
Nataliya I. Lenchik1, 2, F. Giorgianni3, S. BeranovaGiorgianni3, I. C. Gerling1, M. Z. Radic4, A.
Iannaccone2. 1Medicine/Endocrinology, Univ.
Tennessee HSC, Memphis, TN; 2Hamilton Eye
Institute, Univ. Tennessee HSC, Memphis, TN;
3
Pharmaceutical Sciences, Univ. Tennessee HSC,
Memphis, TN; 4Microbiology, Immunology &
Biochemistry, Univ. Tennessee HSC, Memphis, TN
4104 — A0022 Early ocular lipid deposition
in a mouse model of hyperlipidemia and
atherosclerosis. Michaela K. Mathews, T. Albukh,
K. E. Duncan. Ophthalmology, Univ of Maryland,
Baltimore, Baltimore, MD
4105 — A0023 The role of systemic infection
and response to Ranibizumab therapy for Age
Related Macular Degeneration (AMD). Charles
O. Pierce1, 2, M. Nelson2, J. Scott1, H. L. Griffiths1,
N. L. James1, H. A. Thomson1, A. J. Cree1, A. J.
Lotery1, 2. 1Clinical Neurosciences, University of
Southampton, Southampton, United Kingdom;
2
University Hospital of Southampton, Southampton,
United Kingdom *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
274
Wednesday – Posters – 4106 – 4129
4106 — A0024 Immunohistochemical analysis
of primate drusen reveals homologous protein
expression between monkey and human.
Trevor J. McGill1, L. Renner2, A. R. Weiss2, K. D.
Rittenhouse3, J. Lee2, J. Fruebis3, M. Sperling3, M.
Neuringer2. 1Ophthalmology, Casey Eye InstituteOHSU, Portland, OR; 2Neuroscience, Oregon
National Primate Research Center, Beaverton, OR;
3
Ophthalmology External Research Unit, Pfizer,
Cambridge, MA *CR
4107 — A0025 A Pathway-based Genome-wide
Analysis Yields Multi-locus AMD Associations in
Genes Encoding JNK/MAPK Pathway Elements,
Platelet Activation Triggers, and Targets of
miR34 and HDAC1. John Paul P. SanGiovanni.
Clinical Trials Branch, National Eye Institute/NIH,
Bethesda, MD
4108 — A0026 Minocycline protects retinal
pigment epithelial cells from hypoxia. Joanna
DaCosta. Cranfield Health, Cranfield University,
Cranfield, United Kingdom
4109 — A0027 Dominantly Inherited Early
Onset Maculopathy in Japanese Macaques:
Drusen Progression. Anda Cornea1, L. Renner1,
S. Hurst1, T. J. McGill2, M. E. Pennesi2, K. D.
Rittenhouse3, M. Sperling3, J. Fruebis3, M.
Neuringer1, 2. 1Oregon National Primate Research
Center, Oregon Health & Science University,
Beaverton, OR; 2Casey Eye Institute, Oregon
Health & Science University, Portland, OR;
3
Ophthalmology External Research Unit, Pfizer,
Cambridge, MA *CR
4111 — A0029 Biocompatible injectable
hydrogel to extend the release of intravitreal
drugs. Thomas R. Friberg1, 2, B. M. Rauck2, C.
A. Medina-Mendez1, Y. Wang2. 1Ophthalmology/
UPMC Eye Center, Univ of Pittsburgh, Pittsburgh,
PA; 2Bioengineering, University of Pittsburgh,
Pittsburgh, PA *CR
4112 — A0030 Effect of Repeated Delivery
of Neural Progenitors on Vision Preservation
in RCS Rats. Bin Lu1, Y. Tsai1, G. Adamus2, S.
Girman1, L. Shen1, D. M. Gamm3, C. W. Morgans2,
B. Shelley1, C. Svendsen1, S. Wang1. 1Regenerative
Medicine Institute, Cedars Sinai Medical Center,
Los Angeles, CA; 2Casey Eye Institute, Oregon
Health & Science University, Portland, OR;
3
Department of Ophthalmology, University of
Wisconsin, Madison, WI *CR
4113 — A0031 Comparison of intravitreally
injected ranibizumab versus aflibercept in the
retina and choroid of the primate eye. Sylvie
Julien, U. Schraermeyer. Experimental Vitreoretinal
Surgery, Centre for Ophthalmology, Tuebingen,
Germany *CR
4115 — A0033 Metabolites that discriminate
between neovascular AMD and control patients
associate with different ARMS2 genotypes.
Megan B. Parks1, Y. Park2, L. Burgess1, K. Lee3,
P. Sternberg1, D. P. Jones2, M. A. Brantley1.
1
Vanderbilt Eye Institute, Vanderbilt University,
Nashville, TN; 2Department of Medicine, Emory
University, Atlanta, GA; 3Department of Industrial
Engineering, Hanyang University, Seoul, Republic
of Korea
4116 — A0034 The Composition of the
Vitreous Proteome in Patients with Wet AMD
Can Differentiate Between CNV and RAP: An
Important New Diagnostic Tool. Stephanie M.
Ecker, J. C. Hines, A. O. Igbre, B. M. Glaser. Ocular
Proteomics, National Retina Institute, Towson, MD
*CR
4117 — A0035 Metabolic pathways associated
with Age-related Macular Degeneration (AMD).
L. Goodwin Burgess1, Y. Park2, M. B. Parks1, K.
Lee3, P. Sternberg1, D. P. Jones2, M. A. Brantley1.
1
Vanderbilt Eye Institute, Vanderbilt University,
Nashville, TN; 2Department of Medicine, Emory
University, Atlanta, GA; 3Department of Industrial
Engineering, Hanyang University, Seoul, Republic
of Korea
4118 — A0036 Age-related macular
degeneration and complement C3 in liver
transplant patients. Samir Khandhadia1, 2, S.
Hakobyan3, A. J. Cree1, A. J. Lotery1, 2. 1Clinical and
Experimental Sciences, Clinical Neurosciences,
University of Southampton, Southampton,
United Kingdom; 2Eye Unit, University Hospital
Southampton NHS Foundation Trust, Southampton,
United Kingdom; 3School of Medicine, Cardiff
University, Cardiff, United Kingdom *CR
4119 — A0037 Ophthalmologic exam in Age
Macular Degeneration-Alzheimer Disease:
its interest in detection, follow-up of AMD, of
Alzheimer disease, its relevance to highlight
the links and correlations between AMD and
AD. Corinne Gonzalez. Ophthalmology, Cabinet
Medical, Toulouse, France
4120 — A0038 Variants in the VEGFA gene and
visual outcome after anti-VEGF treatment for
neovascular age-related macular degeneration.
Manuel M. Hermann1, P. S. Muether1, D.
Smailhodzic2, A. I. Den Hollander2, B. Kirchhof1, S.
Fauser1. 1Department of Ophthalmology, University
Hospital of Cologne, Koeln, Germany; 2Department
of Ophthalmology, Radboud University Nijmegen
Medical Center, Nijmegen, Netherlands *CR, f
4121 — A0039 Level of vascular endothelial
growth factor 165b in human aqueous humor.
Takayuki Baba, G. Bikbova, M. Kitahashi, H.
Yokouchi, M. Sakurai, M. Kubota-Taniai, S.
Yamamoto. Ophthalmology & Visual Science, Chiba
Univ Grad School of Med, Chiba, Japan
4122 — A0040 Plasma levels of vascular
endothelial growth factor and anti-vascular
endothelial growth factor before and after
intravitreal injection of anti-vascular endothelial
growth factor. Sang Jun Park, M. Yoon, A.
Chung, H. Chin. Department of Ophthalmology,
Inha Vision Science Laboratory, Inha University
School of Medicine, Incheon, Democratic People’s
Republic of Korea
4123 — A0041 Quercetin Protects Hydrogen
Peroxide Damaged Human Retinal Pigment
Epithelial (hRPE) Cells and Inhibits Vascular
Endothelial Growth Factor (VEGF) Production.
Andrew Kumar1, 2, P. C. Kothary2, M. A. Del Monte2.
1
Wayne State University, Detroit, MI; 2Department
of Ophthalmology and Visual Science, University of
Michigan, Ann Arbor, MI
4124 — A0042 Lutein supplementation leads
to a decreased level of circulating complement
factors. Tos TJM Berendschot1, Y. Tian1, I. J.
Murray2, M. Makridaki2, R. van der Veen1, A.
Kijlstra1. 1University Eye Clinic Maastricht,
Maastricht, Netherlands; 2Faculty of Life Sciences,
University of Manchester, Manchester, United
Kingdom f
4125 — A0043 Hyperhomocysteinemia as a risk
factor of polypoidal choroidal vasculopathy. HuiChen Cheng1, 2, P. Lin1, 2. 1Ophthalmology, School of
Medicine, National Yang-Ming University, Taipei,
Taiwan; 2Ophthalmology, Taipei Veterans General
Hospital, Taipei, Taiwan
4126 — A0044 Influence of bevacizumab
on Platelet activation profile in vitro. Bianka
Sobolewska1, F. Ziemssen, C. Grimmel2, J.
Kwiatkowska3, M. S. Spitzer1, M. Gawaz3,
T. Biedermann2, K. Stellos3. 1Centre for
Ophthalmology, University of Tuebingen,
Tuebingen, Germany; 2Dermatology, University of
Tuebigen, Tuebingen, Germany; 3Cardiology and
Cardiovascular Medicine, University of Tuebigen,
Tuebingen, Germany *CR
4127 — A0045 Effects of Plasma Kallikrein on
the neuroretina in diabetic rats. Gongxiong Wu,
E. P. Feener. Vascular Cell Biology, Joslin Diabetes
Center, Boston, MA *CR
4128 — A0046 Choroidal Neovascularization
Response of New Zealand White Rabbits and
Dutch Belt Pigmented Animals to Sustained
Simultaneous Release of both VEGF and bFGF
within the Suprachoroidal Space. Corinne
G. Wong. Ophthalmic Drug Dev, Sclera LLC,
Carlsbad, CA
4129 — A0047 Associations of IL-10 with
Choroidal Neovascularization in high myopia.
Yukimi Yamamoto1, D. Miyazaki1, S. Sasaki2, K.
Miyake1, S. Kaneda1, Y. Ikeda1, A. Yamasaki1, Y.
Inoue1. 1Tottori University, Yonago, Japan; 2Okihospital, Oki District, Japan
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
275
Wednesday Posters
8:30 am – 10:15 am
4110 — A0028 Progression of Atrophic
Macular Degeneration in Rhesus Monkeys
Deficient in Lutein/Zeaxanthin and Omega-3
Fatty Acids. Laurie Renner1, S. Hurst1, T. J.
McGill2, A. R. Weiss1, T. Stout2, D. J. Wilson2, M.
Neuringer1, 2. 1Oregon National Primate Research
Center, Oregon Health & Science University,
Beaverton, OR; 2Casey Eye Institute, Oregon Health
& Science University, Portland, OR *CR
4114 — A0032 Metabolomic profiles distinguish
Age-related Macular Degeneration patients.
Samantha Williamson1, Y. Park3, K. Uppal3, V.
Tran3, J. McGrath2, A. Agarwal1, M. A. PericakVance4, J. L. Haines2, D. P. Jones3, M. A. Brantley1.
1
Vanderbilt Eye Institute, Vanderbilt University,
Nashville, TN; 2Center for Human Genetics
Research, Vanderbilt University, Nashville, TN;
3
Department of Medicine, Emory University,
Atlanta, GA; 4Hussman Institute of Human
Genomics, Miller School of Medicine, University of
Miami, Miami, FL *CR
4130 – 4149 – Wednesday – Posters
Exhibit Hall A0048-A0094
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Retina
414 AMD III, RE
Moderators: Itay Chowers and Christine A. Curcio
4130 — A0048 Focal Retinal Sensitivity Before
and After Selective Retina Therapy for Central
Serous Chorioretinopathy. Ayako Yasui1, M.
Yamamoto1, T. Kohno1, T. yoneda1, Y. Yoshida1,
H. Iwami1, D. Theisen-Kunde2, Y. Miura2, 3, R.
Brinkmann2, K. Shiraki1. 1Ophthalmology and
Visual Science, Osaka city University, Osaka,
Japan; 2Medical Laser Center Luebeck, Luebeck,
Germany; 3Institute of Biomedical Optics,
University of Luebeck, Luebeck, Germany *CR, f
Wednesday Posters
8:30 am – 10:15 am
4131 — A0049 Automatic Temperature
Controlled Retinal Photocoagulation Facilitates
Four Predictable Lesion Strengths Including
Sub-threshold Lesions. Stefan O. Koinzer1,
C. Hesse1, A. Baade2, K. Schlott3, 2, A. Caliebe4,
M. Saeger1, R. Brinkmann3, 2, J. Roider1.
1
Ophthalmology Campus Kiel, University hospital
of Schleswig-Holstein, Kiel, Germany; 2Medical
Laser Center Luebeck GmbH, Luebeck, Germany;
3
Institute of Biomedical Optics, University of
Luebeck, Luebeck, Germany; 4Institute of Medical
Informatics and Statistics, University hospital of
Schleswig-Holstein, Kiel, Germany *CR
4132 — A0050 Modulation of Transgene
Expression in Retinal Gene Therapy by
Selective Laser Treatment. Daniel Lavinsky2, 1,
T. W. Chalberg3, Y. Mandel2, P. Huie2, R. Dalal2,
M. F. Marmor2, D. V. Palanker2. 1Ophthalmology,
Federal Univesity of Rio Grande do Sul, Porto
Alegre, Brazil; 2Ophthalmology and HEPL,
Stanford University, Stanford, CA; 3Avalanche
Biotechnologies, San Francisco, CA *CR
4135 — A0053 Approach to Previously
Vitrectomized Patients with Neovascular AgeRelated Macular Degeneration with Reduced
Response to Anti-vascular Endothelial Growth
Factor Treatment. Mohammad Zubair Y.
Arain1, Q. V. Hoang1, 2, J. S. Slakter2, S. Chang1.
1
Ophthalmology, Edward S. Harkness Eye Institute,
Columbia University Medical Center, New York,
NY; 2Vitreous, Retina, Macula Consultants of New
York, New York, NY *CR
4136 — A0054 Selective retina treatment
(SRT) automatically controlled by a real-time
reflectometry in a rabbit model. Young Jung
Roh1, E. Seifert2, T. Dirk2, Y. Park1, S. Kang1, R.
Brinkmann2. 1Ophthalmology, St Mary’s Hospital,
Seoul, Republic of Korea; 2Biomedical Optics,
University of Lubeck, Lubeck, Germany *CR
4137 — A0055 Effects of repeated subthreshold
micropulse laser photocoagulation in rabbit
eyes. Dongkyu Lee1, H. Kang1, S. Lee2, Y. You1, S.
Kim1, O. Kwon1. 1Retina center, Nune Eye Hospital,
Seoul, Republic of Korea; 2Ophthalmology,
Soonchunhynag University Hospital, Seoul,
Republic of Korea
4138 — A0056 Classification of Rabbit
Photocoagulation Lesions in Optical Coherence
Tomography and Class-related Coagulation
Temperatures. Carola Hesse1, S. O. Koinzer1, A.
Baade2, K. Schlott2, 3, A. Caliebe4, M. Saeger1, R.
Brinkmann3, 2, J. Roider1. 1Dept. of Ophthalmology,
Campus Kiel, University Hospital of SchleswigHolstein, Kiel, Germany; 2Medical Lasercenter
Lübeck GmbH, Lübeck, Germany; 3Institut of
Biomedical Optics, University of Lübeck, Lübeck,
Germany; 4Institut of Medical Informatics and
Statistics, University Hospital of SchleswigHolstein, Kiel, Germany *CR
4139 — A0057 Various Laser Treatments for
Retinal Capillary Hemangioma. Liqin Gao, F.
Zhang. Department of Ophthalmology, Beijing
Tongren Hospital, Beijing, China
4133 — A0051 Fluorescein angiography
versus superimposed OCT-guided macular laser
photocoagulation. Igor Kozak1, 2, S. El-Emam1, L.
Cheng1, D. G. Bartsch1, J. Chhablani3, W. Freeman1,
N. G. Ghazi2, J. Arevalo2, 4. 1Ophthalmology,
University of California San Diego, La Jolla, CA;
2
Vitreoretinal Division, King Khaled Eye Specialist
Hospital, Riyadh, Saudi Arabia; 3Vitreoretina, LV
Prasad Eye Institute, Heyderabad, India; 4Wilmer
Eye Institute, Johns Hopkins University, Baltimore,
MD *CR
4140 — A0058 Subthreshold diode micropulse
laser photocoagulation versus low-fluence
photodynamic therapy for the treatment of
chronic central serous chorioretinopathy.
Juan Giralt1, R. P. Casaroli-Marano1, A. BurésJelstrup2, R. Navarro2, J. Martinez-Toldos3, C.
Fernandez-Martinez3, M. Alforja1, A. Rey Torrente1.
1
Ophthalmology, Hospital Clinic de Barcelona,
Barcelona, Spain; 2IMO, Barcelona, Spain;
3
Hospital General Universitario de Elche, Elche,
Spain *CR
4134 — A0052 Six-month Report of
Selective Retina Therapy on Central Serous
Chorioretinopathy in Japanese Patients. Manabu
Yamamoto1, T. Kohno1, T. Voneda1, Y. Yoshida1, H.
Iwami1, A. Yasui1, D. Theisen-Kunde2, Y. Miura3,
R. Brinkmann3, 2, K. Shiraki1. 1Ophthalmology &
Visual Sciences, Osaka City Univ Grad School
of Medicine, Osaka-Shi, Japan; 2Medical Laser
Center Luebeck, Luebeck, Germany; 3Institute
of Biomedical Optics, University of Luebeck,
Luebeck, Germany *CR, f
4141 — A0059 Early changes on SD-OCT
in eyes with cystoid macular edema (CME)
after 577 nm subthreshold MicroPulse Laser
Treatment (MPLT). Paola Salvetti1, L. de Polo1, 2,
M. Oldani1, 2, R. Ruello1. 1Centro Oculistico
Bergamasco, Bergamo, Italy; 2Eye Clinic
Department of Biomedical and Clinical Science
“Luigi Sacco”, Luigi Sacco Hospital, Milano, Italy
4142 — A0060 Threshold and Subthreshold
Retinal Laser Therapy. But which Threshold?
Giorgio Dorin. Clinical Application Development,
IRIDEX Corp, Mountain View, CA *CR
4143 — A0061 Persistence of Weekly Vision
Self-monitoring Behavior in Non-Neovascular
Age-Related Macular Degeneration Subjects
Randomized to the Vision and Memory
Stimulating (VMS) booklet. Mark C. Roser1, P.
Beaton1, S. Torr-Brown1, A. Nwanko2, G. Dagnelie2,
A. K. Bittner2. 1Results Group, LLC, Hebron, CT;
2
1Johns Hopkins Wilmer Eye Institute, Baltimore,
MD *CR, f
4144 — A0062 Screening for AMD at an
University Hospital: Database análisis and
considerations. Carmen N. Demetrio, M. Zas.
Ophthalmology, Hospital de Clínicas, Buenos Aires,
Argentina
4145 — A0063 Zinc supplementation lowers
complement overactivation in patients with
age-related macular degeneration. B. Jeroen
Klevering1, D. Smailhodzic1, A. I. Den Hollander1, 2,
J. P. van de Ven1, J. M. Groenewoud3, S. Fauser4,
M. R. Daha5, G. van der Wilt3, C. B. Hoyng1.
1
Ophthalmology, Radboud University Nijmegen
Medical Centre, Nijmegen, Netherlands;
2
Department of Human Genetics, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands; 3Department of Epidemiology,
Biostatistics, and HTA, Radboud University
Nijmegen Medical Centre, Nijmegen, Netherlands;
4
Ophthalmology, University of Cologne, Cologne,
Germany; 5Department of Nephrology, Leiden
University Medical Center, Leiden, Netherlands f
4146 — A0064 Novel Laser treatment for
Early Age-related Macular Degeneration. Kate
Brassington1, L. Gurrin3, K. Aung1, R. H. Guymer1, 2.
1
Centre for Eye Research Australia, Royal Victorian
Eye and Ear Hospital, Melbourne, VIC, Australia;
2
Department of Ophthalmology, University of
Melbourne, Melbourne, VIC, Australia; 3Melbourne
School of Population Health, University of
Melbourne, Melbourne, VIC, Australia *CR, f
4147 — A0065 ex vivo Spectral Domain
Optical Coherence Tomography (SD-OCT)
of Retina-Choriocapillaris (R-CC) Specimen:
Factors influencing Image Quality. Laurenz L.
Sonnentag, S. Grisanti, M. Rudolf. Department of
Ophthalmology, University of Luebeck, Luebeck,
Germany *CR
4148 — A0066 Quantitative Optical Coherence
Tomography Analysis Of Change in Pigment
Epithelial Detachment Morphology Following
Intravitreal Aflibercept Injection In Eyes With
Recalcitrant Neovascular Age-Related Macular
Degeneration. Mihai Mititelu, D. S. Grewal,
D. Sarezky, R. Mirza, M. K. Gill, A. T. Lyon.
Ophthalmology, Northwestern University, Feinberg
School of Medicine, Chicago, IL
4149 — A0067 Drusen Detection on
Multimodal Imaging- Early Markers
Observational Study. Rufino Silva1, 2, R. E. Hogg3,
G. Murphy3, G. Staurenghi4, C. Rosina4, A. Santos2,
U. Chakravarthy3. 1Ophthalmology, Universitary
Hospital Coimbra Center, Coimbra, Portugal; 2CEC,
AIBILI, Coimbra, Portugal; 3Center for Vision
and Vascular Science, Queen’s University Belfast,
Belfast, Ireland; 4Dept of Biomedical and Clinical
Science (Luigi Sacco), University of Milan, Milan,
Italy *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
276
Wednesday – Posters – 4150 – 4169
4150 — A0068 Automated prediction of AMD
progression from quantified SD-OCT images.
Theodore Leng1, L. de Sisternes2, Q. Chen2, 3, J. Ma1,
V. Mahendra1, D. Rubin2. 1Ophthalmology, Byers
Eye Institute at Stanford, Palo Alto, CA; 2Radiology
and Medicine (Biomedical Informatics Research),
Stanford University School of Medicine, Stanford,
CA; 3School of Computer Science and Engineering,
Nanjing University of Science and Technology,
Nanjing, China *CR
4157 — A0075 The Dynamics of
Hyperreflectant Central Target Lesions
In Reticular Macular Disease (RMD) In
Age-related Macular Degeneration (AMD).
Nicole M. Pumariega1, R. M. Cymerman1, B.
Butler1, N. Massamba2, E. H. Souied2, R. Smith1.
1
Ophthalmology, New York University Medical
Center, College of Medicine, New York, NY;
2
Retina Creteil, Creteil Eye Clinic Univ Hospital,
Créteil, France *CR
4163 — A0081 Dark Adaptometry As a
Functional Outcome Measure in Age-Related
Macular Degeneration. E Lauren Doss1, 2, T.
Glaser1, 2, E. Agrón2, D. L. Nigam2, W. T. Wong3,
E. Y. Chew2, C. A. Cukras2. 1School of Medicine,
University of California-San Francisco, San
Francisco, CA; 2National Eye Insititute, National
Institutes of Health (NIH), Bethesda, MD; 3Office
of the Scientific Director, National Eye Institute,
National Institutes of Health (NIH), Bethesda, MD
4151 — A0069 Significance of Drusen
Regression in Intermediate Age-Related Macular
Degeneration (AMD) in Progression to Advanced
Disease. Tanya Glaser1, 2, E. Doss1, 2, E. Agrón1,
D. L. Nigam1, E. Y. Chew1, W. T. Wong3. 1National
Eye Institute, National Institutes of Health (NIH),
Bethesda, MD; 2School of Medicine, University
of California - San Francisco, San Francisco, CA;
3
Office of the Scientific Director, National Eye
Institute, National Institutes of Health (NIH),
Bethesda, MD
4158 — A0076 Relationship between
reflectivity and volume of subretinal tissue in
choroidal neovascular membranes associated
with age-related macular degeneration. Wissam
Charafeddin, S. Sadda, M. Nittala, M. S. Humayun,
A. A. Oregon-Miranda. Doheny eye institute, Los
angeles, CA *CR
4164 — A0082 Diagnostic accuracy of
multifocal pupillographic objective perimetry in
early age-related macular degeneration. Faran
Sabeti1, 2, A. Saikal1, 2, M. Kolic1, 2, C. F. Carle1, 2,
R. W. Essex3, A. C. James1, 2, T. Maddess1, 2. 1Eccles
Institute of Neuroscience, Australian National
University, Canberra, ACT, Australia; 2ARC
Centre of Excellence in Vision Science, Canberra,
ACT, Australia; 3Ophthalmology Department, The
Canberra Hospital, Canberra, ACT, Australia *CR
4152 — A0070 The evaluation of fundus autofluorescence ( FAF) patterns in patient’s with
Geographic Atrophy( GA) and the correlation
with visual acuity. Ina K. Jaurre, S. Mudhar,
N. Jain, M. Polyzos, G. Menon, L. North, M.
N. Chandran. Eye treatment unit, Frimley Park
Hospital, Frimley, Surrey, United Kingdom *CR
4154 — A0072 Automated Drusen
Segmentation and Quantification from SDOCT Images to Predict AMD Progression.
Luis de Sisternes1, T. Leng2, Q. Chen3, J. Ma2, V.
Mahendra2, D. Rubin1. 1Radiology and Medicine,
Stanford University School of Medicine, Stanford,
CA; 2Ophthalmology, Byers Eye Institute at
Stanford, Palo Alto, CA; 3School of Computer
Science and Engineering, Nanjing University of
Science and Technology, Nanjing, China *CR
4155 — A0073 Factors that predict the
incidence of fellow eye in age-related macular
degeneration. Kyung Min Koh, Y. Lew, M. Choi, S.
Yoo, S. Cho, D. Lee, T. Lee, C. Kim, J. Han. Kim’s
Eye Hospital, Seoul, Republic of Korea
4156 — A0074 Development of Choroidal
Neovascularization in the Second Eye of
Neovascular AMD Patients Treated with AntiVEGF Drugs. Jonah Abraham, M. J. Elman. Elman
Retina Group, PA, Baltimore, MD *CR
4160 — A0078 OPERA (Optos Peripheral
Retina AMD) Study Croatia: Reticular
pigmentation in AMD vs. controls. Vesna Jurisic
Friberg1, 3, B. Andrijevic Derk2, T. Knezevic2,
M. Zoric-Geber2, G. Bencic2, Z. Vatavuk2, T.
R. Friberg4, 2. 1University Eye Clinic, Clinical
Center, University of Sarajevo, Sarajevo, Bosnia
and Herzegovina; 2Ophthalmology, Kbc Sestre
Milosrdnice and the University of Zagreb, Zagreb
Croatia, Zagreb, Croatia; 3Ophthalmology,
Children’s Hospital-UPMC, Pittsburgh, PA;
4
Ophthalmology, UPMC Eye Center, University of
Pittsburgh, Pittsburgh, PA *CR
4161 — A0079 Morphological characteristics
associated with drusen progression on Spectral
Domain OCT (SD-OCT). Jeong W. Pak1, A.
Domalpally1, D. Myers1, X. Yang2, A. R. Narkar1, Y.
Huang1, R. P. Danis1. 1Ophthalmology and Visual
Science, University of Wisconsin - Madison,
Madison, WI; 2Beijing Tongren Eye Center, Capital
Medical University, Beijing, China *CR
4162 — A0080 Clinical Outcomes of Eyes
with Neovascular Lesions Composed of >50%
Blood Treated with Anti-VEGF Therapy in the
Comparison of AMD Treatments Trials (CATT).
Michael M. Altaweel1, J. E. Grunwald2, E. Daniel2,
G. Ying2, J. Huang2, G. J. Jaffe3. 1Ophthalmology
& Visual Science, Univ of Wisconsin-Madison,
Madison, WI; 2Department of Ophthalmology,
University of Pennsylvania, Philadelphia, PA;
3
Ophthalmology, Duke University, Durham, NC
*CR, f
4165 — A0083 Imaging of Focal
Hyperpigmentary Changes in Intermediate Agerelated Macular Degeneration - A Longitudinal
Analysis. Arno P. Goebel, S. Grundei, M.
Fleckenstein, F. G. Holz, S. Schmitz-Valckenberg.
Department of Ophthalmology, University of Bonn,
Bonn, Germany *CR
4166 — A0084 Reduction of the OCT second
hyper-reflective band intensity is associated with
a decreased in retinal function in eyes with agerelated macular degeneration. Chi D. Luu1, 2, Z.
Wu1, 2, L. N. Ayton1, 2, R. H. Guymer1, 2. 1Macular
Research Unit, Centre for Eye Research Australia,
East Melbourne, VIC, Australia; 2Department of
Ophthalmology, University of Melbourne, Parkville,
VIC, Australia *CR
4167 — A0085 Progression of Reticular
Macular Disease (RMD) in Age-Related Macular
Degeneration (AMD). Rachel M. Cymerman1, N.
M. Pumariega1, A. G. Sperber1, N. Massamba2,
E. H. Souied2, R. Smith1. 1New York University
Medical Center, School of Medicine, New York,
NY; 2L’Hôpital Intercommunal de Créteil, Créteil,
France *CR
4168 — A0086 Imaging of reticular drusen
by multi-spectral confocal scanning laser
ophthalmoscopy imaging. Jasmin Anke Ilka Auge,
J. S. Steinberg, M. Fleckenstein, F. G. Holz, S.
Schmitz-Valckenberg. University of Bonn, Bonn,
Germany *CR
4169 — A0087 Reticular Pseudodrusen in
Early Age-Related Macular Degeneration is
Associated with Choroidal Thinning. Aakriti
Garg1, M. Oll1, S. Yzer1, R. Allikmets1, 2, S. Chang1,
G. R. Barile3, R. Smith4, J. C. Merriam1, S. H.
Tsang1, 2, S. Bearelly1. 1Ophthalmology, Columbia
University College of Physicians and Surgeons,
New York, NY; 2Pathology & Cell Biology,
Columbia University College of Physicians and
Surgeons, New York, NY; 3Ophthalmology,
Manhattan Eye, Ear, & Throat Hospital, New York,
NY; 4Ophthalmology, New York University Medical
Center, New York, NY *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
277
Wednesday Posters
8:30 am – 10:15 am
4153 — A0071 Investigation into the ability
of Preferential Hyperacuity Perimetry (PHP)
to detect reactivation of neovascularisation in
patients undergoing ranibizumab injections
for age-related macular degeneration (AMD).
Stephanie Mroczkowska1, A. Calcagni3, 1, J.
M. Gibson1, U. Chakravarthy2, R. E. Hogg2.
1
Ophthalmic Research Group, Aston University,
Birmingham, United Kingdom; 2Centre for Vision
and Vascular Science, Queen’s University Belfast,
Belfast, Ireland; 3Birmingham and Midland Eye
Centre, Birmingham, United Kingdom *CR
4159 — A0077 Rod and Cone function and
its relationship to OCT sub structural changes
in Age-related Macular degeneration. Brighu
Swamy1, E. N. Wong3, S. Degli Esposti1, P. A.
Keane2, 1, M. D. Crossland1, D. A. Sim1, A. Tufail1, 2,
F. K. Chen3. 1Medical Retina, Moorfields Eye
Hospital, London, United Kingdom; 2UCL Institute
of Ophthalmology National Institute for Health
Research Biomedical Research Centre, London,
United Kingdom; 3Lions Eye Institute, Perth, WA,
Australia *CR
4170 – 4188 – Wednesday – Posters
4170 — A0088 Reticular pseudodrusen and
their topographic relation to choroidal watershed
zones and localized changes in choroidal volume
and choroidal thickness. Florian Alten, C. R.
Clemens, N. Eter. University Eye Hosp Muenster,
Muenster, Germany *CR
4171 — A0089 Long-term evaluation of
drusen area and volume using polarizationsensitive OCT. Ferdinand G. Schlanitz1, B.
Baumann2, M. Bolz1, E. Gotzinger2, M. Pircher2,
C. K. Hitzenberger2, U. Schmidt-Erfurth1.
1
Ophthalmology, Medical University of Vienna,
Vienna, Austria; 2Center for Medical Physics and
Biomedical Engineering, Medical University of
Vienna, Vienna, Austria *CR
4172 — A0090 Longitudinal analysis of
reticular drusen associated with age-related
macular degeneration. Julia S. Steinberg, J.
Auge, M. Fleckenstein, F. G. Holz, S. SchmitzValckenberg. Department of Ophthalmology,
University of Bonn, Bonn, Germany *CR
Wednesday Posters
8:30 am – 10:15 am
4173 — A0091 Preferential Hyperacuity
Perimetry Monitoring in Patients During
Treatment of Neovascular Age-related Macular
Degeneration. Merina Thomas1, 2, Y. Wolfson1, V.
Chaikitmongkol1, 3, N. M. Bressler1. 1Department
of Ophthalmology, Retina Division, Wilmer
Eye Institute, Johns Hopkins University School
of Medicine, Baltimore, MD; 2Department of
Ophthalmology, University of Illinois at Chicago,
Chicago, IL; 3Department of Ophthalmology,
Chiang Mai University, Chiang Mai, Thailand *CR
4174 — A0092 Visual outcomes of an Inject
and Extend protocol of intravitreal antivascular endothelial growth factor treatment in
neovascular age-related macular degeneration
over two years. Farshad Abedi, S. Wickramsinghe,
A. Islam, K. M. Inglis, R. H. Guymer.
Ophthalmology, Centre for Eye Research Australia,
University of Melbourne, Royal Victorian Eye and
Ear Hospital, East Melbourne, VIC, Australia *CR
4175 — A0093 Prospective Randomized
Controlled Trial of Combination Ranibizumab
and Ketorolac for Wet Age-Related Macular
Degeneration. Andrea Russo1, C. Costagliola2, L.
Delcassi1, M. R. Romano3, F. Semeraro1. 1Univ degli
Studi di Brescia - Italy, Brescia, Italy; 2Università
del Molise, Campobasso, Italy; 3Istituto Clinico
Humanitas, Milano, Italy *CR
4176 — A0094 Aflibercept Rescue of
Bevacizumab- or Ranibizumab-Resistant
Choroidal Neovascularization in Age-Related
Macular Degeneration. Cheryl A. Arcinue, F. Ma,
G. Barteselli, S. Lee, S. El-Emam, A. L. Doede, M.
Gomez, W. Freeman. Jacobs Retina Center, UCSD
Shiley Eye Center, La Jolla, CA *CR
Exhibit Hall B0170-B0195
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
415 Retinal and Photoreceptor
Degeneration II: Cell Biology
Moderators: Susan E. Brockerhoff and
Ulrich F. Luhmann
4177 — B0170 Myo/Nog Cells Promote
Photoreceptor Cell Survival in the Stressed
Retina. Arturo Bravo-Nuevo1, A. Brandli2, J. V.
Gerhart1, M. Pitts1, J. Stone2, M. George-Weinstein1.
1
Lankenau Institute for Medical Research,
Wynnewood, PA; 2Physiology, University of
Sydney, Sydney, NSW, Australia *CR
4178 — B0171 Responsiveness of rhodopsin
kinase GRK1 promoter activity to light. Shahrokh
C. Khani, Z. Oskouie. Ophthalmology, Schepens
Eye Research Inst, Boston, MA
4179 — B0172 Early indications of pending
degeneration in a mouse model of photoreceptor
light damage. Emily Levine1, R. J. Zawadzki2, H.
Cheng3, S. I. Simon4, E. N. Pugh1, 5, M. E. Burns1, 2.
1
Cell Biology and Human Anatomy, UC Davis,
Davis, CA; 2Ophthalmology & Vision Science,
UC Davis, Davis, CA; 3Neurobiology, Physiology
and Behavior, UC Davis, Davis, CA; 4Biomedical
Engineering, UC Davis, Davis, CA; 5Physiology
and Membrane Biology, UC Davis, Davis, CA
4180 — B0173 Constitutive Rhodopsin
Activation rather than Mistrafficking Results in
Photoreceptor Death in the D190N Preclinical
Model of Retinitis Pigmentosa. Javier SanchoPelluz1, 2, W. Lee1, Y. Tsai1, I. Washington1, S. H.
Tsang1, 4, C. Lin3, 4. 1Department of Ophthalmology,
Columbia University, New York, NY; 2Department
of Medicine, Catholic University of Valencia,
Valencia, Spain; 3Herbert Irving Comprehensive
Cancer Center, Columbia University, New York,
NY; 4Department of Pathology and Cell Biology,
College of Physicians and Surgeons, Columbia
University, New York, NY
4181 — B0174 Insufficient proteasomal activity
is a common stress factor in multiple forms
of inherited retinal degeneration. Ekaterina
Lobanova, S. Finkelstein, N. P. Skiba, V. Y.
Arshavsky. Albert Eye Research Institute, Durham,
NC
4182 — B0175 Decreased Proteasomal Activity
Causes Retinal Degeneration in Mice. Ryo
Ando1, 2, K. Noda1, 2, U. Tomaru3, M. Kamoshita4,
Y. Ozawa4, S. Notomi5, T. Hisatomi5, A. Kanda1, 2,
S. Ishida1, 2. 1Laboratory of Ocular Cell Biology
and Visual Science, Hokkaido University Graduate
School of Medicine, Sapporo, Japan; 2Department
of Ophthalmology, Hokkaido University
Graduate School of Medicine, Sapporo, Japan;
3
Department of Pathology, Hokkaido University
Graduate School of Medicine, Sapporo, Japan;
4
Department of Ophthalmology, Keio University
School of Medicine, Tokyo, Japan; 5Department
of Ophthalmology, Graduate School of Medical
Sciences, Kyushu University, Fukuoka, Japan *CR
4183 — B0176 Rod Photoreceptor neuritic
sprouting is responsive to Sema3A. Frank
Kung1, 2, A. Axelrod3, D. R. Siegel3, E. TownesAnderson1. 1Biomedical Engineering, UMDNJ,
Newark, NJ; 2Biomedical Engineering, NJIT,
Newark, NJ; 3Department of Chemistry and
Biochemistry, The University of Texas at Austin,
Chesapeake, VA
4184 — B0177 Strain Dependence of Myeloid
Cell-Associated Retinal Dysplasia in Crb1rd8
Mice. Mark P. Krebs, W. Hicks, L. Stone, J.
Naggert, P. M. Nishina. The Jackson Laboratory,
Bar Harbor, ME
4185 — B0178 The genetic background
determines the severity of retinal pathology
in homozygous Crb1rd8/rd8 mice. Ulrich F.
Luhmann1, L. S. Carvalho1, J. Cowing1, P. M.
Munro4, P. Potter3, J. W. Bainbridge1, 2, R. R.
Ali1, 2. 1Department of Genetics, UCL Institute
of Ophthalmology, London, United Kingdom;
2
NIHR Moorfields Biomedical Research Centre at
Moorfields Eye Hospital NHS Foundation Trust
and UCL Institute of Ophthalmology, London,
United Kingdom; 3MRC Harwell, Oxfordshire,
United Kingdom; 4Imaging Unit, UCL Institute of
Ophthalmology, London, United Kingdom *CR
4186 — B0179 Characterization of a Novel
Mouse Mutant with Retinal Degeneration and
Male Infertility. Chun-hong Xia1, B. Chang2,
X. Gong1. 1School of Optometry, University of
California, Berkeley, Berkeley, CA; 2The Jackson
Laboratory, Bar Harbor, ME
4187 — B0180 Electroretinographic and
OCT Retinal Morphologic Characterization
of the CrxRdy Cat: An Animal Model for Severe
Dominant Retinopathies Associated with CRX
Mutations. Laurence M. Occelli1, J. T. Bartoe1,
J. R. Querubin1, K. Narfstrom2, S. M. PetersenJones1. 1Small Animal Clinical Sciences, Michigan
State University, East Lansing, MI; 2Dept of Vet
Med & Surgery, University of Missouri-Columbia,
Columbia, MO
4188 — B0181 Comparative analysis of
neurodegenerative markers in ten different
animal models for retinal degeneration
reveals prevalence of non-apoptotic cell death
mechanisms. Blanca Arango-Gonzalez1, D.
Trifunović1, A. Sahaboglu-Tekgöz1, K. Kranz2,
S. Michalakis3, P. Farinelli1, 4, S. Cottet5, P.
A. Ekstrom4, M. Ueffing1, F. Paquet-Durand1.
1
Institute for Ophthalmic Research, Centre for
Ophthalmology, Eberhard Karls-Universität
Tübingen, Tuebingen, Germany; 2Department of
Neurobiology, University of Oldenburg, Oldenburg,
Germany; 3Center for Integrated Protein Science
Munich (CIPSM) and Department of Pharmacy,
Center for Drug Research, Ludwig-MaximiliansUniversität München, Munich, Germany; 4Division
of Ophthalmology, Department of Clinical Sciences,
University of Lund, Lund, Sweden; 5Institute
for Research in Ophthalmology, University of
Lausanne, Lausanne, Switzerland
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
278
Wednesday – Posters – 4189 – 4209
4189 — B0182 Mechanism of cGMP-induced
Retinal Degeneration. Tian Wang1, J. Chen1, S. H.
Tsang2. 1Zilkha Neurogenetic Institute, Keck School
of Medicine, University of Southern California, Los
Angeles, CA; 2Bernard & Shirlee Brown Glaucoma
Laboratory, Edward S. Harkness Eye Institute, and
Department of Pathology & Cell Biology, Columbia
University, New york, NY
4190 — B0183 Genetic deletion of S-opsin
prevents rapid cone degeneration in a mouse
model of Leber congenital amaurosis. Tao
Zhang1, 2, A. Jones1, 2, S. Wang1, 2, E. N. Pugh3, W.
Baehr1, 2, Y. Fu1, 2. 1Dept of Ophthalmology and
Visual Sciences, University of Utah, Salt Lake City,
UT; 2Neurobiology & Anatomy, University of Utah,
Salt Lake City, UT; 3Departments of Physiology
and Cell Biology, University of California, Davis,
CA *CR
4191 — B0184 Gene Expression Alterations
in Mouse Retina with Deficiency of Cone Cyclic
Nucleotide-gated Channel Subunits CNGA3 and
CNGB3. Hongwei Ma1, A. Thapa1, L. M. Morris1,
S. Michalakis2, M. Biel2, M. B. Frank3, M. Bebak3,
X. Ding1. 1The Department of Cell Biology, Univ
of Oklahoma Health Sci Ctr, Oklahoma City, OK;
2
The Center for Integrated Protein Science Munich
(CIPSM) and Department of Pharmacy - Center for
Drug Research, Ludwig-Maximilians-Universität
München, Munich, Germany; 3The Arthritis and
Clinical Immunology Program, Oklahoma Medical
Research Foundation, Oklahoma City, OK
4192 — B0185 Inhibition of S1P degradation
rescues 661W cells from oxidative stress. Carlotta
Fabiani, P. Signorelli, A. Caretti, R. Ghidoni.
Department of Health Sciences, University of
Milan, Milan, Italy
4194 — B0187 Molecular mechanisms that
contribute to vision loss in T17M RHO mice.
Sonali R. Nashine1, Y. Bhootada2, A. S. Lewin3,
M. S. Gorbatyuk1, 2. 1Cell Biology and Anatomy,
Univ of North Texas Hlth Sci Ctr, Fort Worth,
TX; 2University of Alabama, Birmingham, AL;
3
University of Florida, Gainsville, FL *CR
4198 — B0191 The Protective effects
of Resveratrol in Experimental Retinal
Detachment. Wei Huang, G. Li, J. Qiu, P.
Gonzalez, P. Challa. Ophthalmology, Duke Eye
Center, Durham, NC
4199 — B0192 LED light source induced
retinal photoreceptor hazard in a rat model.
Yu-Man Shang1, 2, C. Yang2, 3, G. Wang1, 4, L. Lin1, 2.
1
Institute of Environmental Health, National
Taiwan University, Taipei, Taiwan; 2Department
of Ophthalmology, National Taiwan University
Hospital, Taipei, Taiwan; 3College of Medicine,
National Taiwan University, Taipei, Taiwan;
4
Department of Public Health, National Taiwan
University, Taipei, Taiwan
4200 — B0193 Neuroprotective effects of
norgestrel in retinitis pigmentosa: preservation
of retinal cytoarchitecture and synaptic
connectivity. Violeta Gomez-Vicente1, L.
Fernandez-Sanchez1, G. Groeger2, F. Doonan2, T.
G. Cotter2, N. Cuenca1. 1Physiology, Genetics &
Microbiology, University of Alicante, Alicante,
Spain; 2Biochemistry, BioSciences Institute,
University College Cork, Cork, Ireland *CR
4201 — B0194 Manipulating MSC Homing
To Enhance Its Efficacy in Preserving Vision.
Shaomei Wang1, Y. Tsai1, S. Girman1, L. Shen1,
C. W. Morgans2, G. Adamus3, W. Xiong1, V.
Arumugaswami1, C. Svendsen1, B. Lu1. 1Biomedical
Science, Regenerative Medicine Institute, Los
Angeles, CA; 2Physiology & Pharmacology,
OHSU, Portland, OR; 3Casey Eye Institute, OHSU,
Portland, OR
4202 — B0195 NecroX-5 Rescue Retinal
Degeneration Induced by N-methyl-Nnitrosourea in Rats. Sun-Sook Paik, J. Jeon, I.
Kim. Anatomy, College of Medicine, The Catholic
University of Korea, Seoul, Republic of Korea
Exhibit Hall B0196-B0249
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Anatomy/Pathology / Physiology/Pharmacology
416 Uveal Melanoma
Moderators: Tatyana Milman and Rebecca Stacy
4203 — B0196 Comparison of Two Melanoma
Cell Lines as Mouse-Models of Uveal Melanoma.
Marta M. Kilian1, K. U. Loeffler1, H. E.
Grossniklaus2, F. G. Holz1, C. Pfarrer3, C. Kurts4,
M. C. Herwig1. 1Department of Ophthalmology,
University of Bonn, Bonn, Germany; 2Department
of Ophthalmology, Emory University, Atlanta, GA;
3
Department of Anatomy, University of Veterinary
Medicine Hannover, Hannover, Germany;
4
Institutes of Molecular Medicine and Experimental
Immunology, University of Bonn, Bonn, Germany
*CR
4204 — B0197 Calcium regulation by transient
receptor potential channels in human uveal
melanoma cells. Stefan Mergler1, A. Boehm1, R.
Derckx1, L. Schmelzer1, F. Garreis2, A. Riechardt1.
1
Department of Ophthalmology, University
Medicine Charite Berlin, Berlin, Germany;
2
Department of Anatomy II, University ErlangenNuremberg, Erlangen, Germany
4205 — B0198 Unusual sodium-potassium
dynamics and Na,K-ATPase expression in Mel290 uveal melanoma cells. Elena B. Rodriguez de
Turco, N. A. Delamere, M. Shahidullah. Physiology,
University of Arizona, Tucson, AZ
4206 — B0199 Host Pigment EpitheliumDerived Factor (PEDF) Prevents Progression
of Uveal Melanoma Metastasis in the Liver
and Inhibits Formation of Blood Vessels in the
Metastatic Microenvironment. John M. Lattier1,
H. Yang1, S. Crawford2, H. E. Grossniklaus1. 1Dept.
of Ophthalmology, Emory University, Atlanta, GA;
2
Dept. of Pathology, University of St. Louis, St.
Louis, MO
4207 — B0200 Pre-clinical analysis of
Crizotinib in MAPK independent uveal
melanoma metastases. Pieter van der Velden, M.
de Lange, M. Versluis, G. P. Luyten, M. M. Jager.
Ophthalmology, LUMC, Leiden, Netherlands
4195 — B0188 Extracellular ATP accelerates
photoreceptor cell death via ligation of P2X7
receptor in retinal detachment. Shoji Notomi,
T. Hisatomi, Y. Murakami, A. Takeda, Y. Ikeda,
H. Enaida, T. Ishibashi. Ophthalmology, Kyushu
University, Fukuoka, Japan *CR
4208 — B0201 Vemurafenib as a therapeutic
option for treatment of melanoma. Simon F.
Leicht, C. M. Wertheimer, R. Liegl, A. Kampik,
K. Eibl-Lindner. Department of Ophthalmology,
Ludwig-Maximilians-University, Munich, Germany
*CR
4196 — B0189 Identification and
characterization of Tubby C-terminal binding
proteins by ORF phage display. Nora B.
Caberoy1, G. S. Alvarado2, J. N. Nocillado1. 1School
of Life Sciences, University of Nevada Las Vegas,
Las Vegas, NV; 2Ophthalmology, Bascom Palmer
Eye Institute, University of Miami Miller School of
Medicinel, Miami, FL
4209 — B0202 5-Azacytidine Reduces
Growth, Invasiveness, and Clonogenicity of
Uveal Melanoma Cells and Decreases the Rate
of Metastasis. Fatemeh Rajaii, L. Asnaghi, S.
L. Merbs, J. T. Handa, C. Eberhart. Department
of Ophthalmology, Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
279
Wednesday Posters
8:30 am – 10:15 am
4193 — B0186 Calcium fluxes in degenerating
pde6cw59 mutant zebrafish cones indicate a
non-apoptotic mechanism of cell death. Susan
E. Brockerhoff, E. Y. Ma, A. Lewis, G. Stearns.
Biochemistry, University of Washington, Seattle,
WA
4197 — B0190 Interaction of Tubby-like
protein-1 (Tulp1) and Microtubule-Associated
Proteins (MAPs) in the Mouse Retina. Lindsey
A. Ebke1, G. H. Grossman1, C. D. Beight1, G. J.
Pauer1, S. A. Hagstrom1, 2. 1Cole Eye Institute,
Cleveland Clinic, Cleveland, OH; 2Department of
Ophthalmology, Cleveland Clinic Lerner College
of Medicine of Case Western Reserve University,
Cleveland, OH
4210 – 4233 – Wednesday – Posters
4210 — B0203 Cytotoxic Effects of the
Combination of Resveratrol and N-acetylcysteine
on Cultured Human Uveal Melanoma Cells.
Tommaso Vagaggini1, 2, D. Hu2, A. Sclafani2, S. A.
McCormick2, J. E. Roberts1. 1Natural Sciences,
Fordham University, New York, NY; 2Pathology,
New York Eye and Ear Infirmary, New York, NY
*CR
4211 — B0204 Simultaneous Inhibition of
the HGF/MET and Erk1/2 Pathways Affect
Uveal Melanoma Cell Growth and Migration.
Chandrani Chattopadhyay, E. A. Grimm, S. E.
Woodman. Melanoma Medical Oncology, UT MD
Anderson Cancer Ctr, Houston, TX *CR
4212 — B0205 Cyclooxygenase-2 (COX-2)
expression in primary uveal melanoma and the
potential role for adjuvant treatment with COX2 inhibitors. Lindsay E. Adam, J. B. Massengill, C.
M. Cebulla, M. H. Abdel-Rahman. Ophthalmology,
The Ohio State University, Columbus, OH
4213 — B0206 Antimicrobial Peptide
Expression and Potential Roles in Uveal
Melanoma Pathogenesis. Joseph C. Manarang,
D. C. Otteson, A. Glasser, A. R. Burns, A. M.
McDermott. College of Optometry, University of
Houston, Houston, TX
4214 — B0207 Improved Specimen Handling
for Optimizing Diagnostic Yield from Fine
Needle Aspiration Biopsy of Uveal Tumors.
Nieraj Jain, V. M. Elner, H. Demirci. University of
Michigan, Ann Arbor, MI *CR
Wednesday Posters
8:30 am – 10:15 am
4215 — B0208 Heterogeneity of Monosomy 3
in Fine Needle Aspiration Biopsy of Choroidal
Melanoma. Melinda Chang, N. Rao, L. Johnson, T.
McCannel. Jules Stein Eye Institute, Los Angeles,
CA
4216 — B0209 Prognostic FNAB of Uveal
Melanoma. Arun D. Singh1, 5, M. E. Aronow1, C.
V. Biscotti2, R. Tubbs3, L. Schoenfield2, P. Triozzi4,
5 1
. Ophthalmic Oncology, Cole Eye Institute,
Cleveland, OH; 2Anatomic Pathology, Cleveland
Clinic, Cleveland, OH; 3Molecular Pathology,
Cleveland Clinic, Cleveland, OH; 4Solid tumor
Oncology, Cleveland Clinic, Cleveland, OH;
5
Taussig Cancer Center, Cleveland Clinic,
Cleveland, OH
4217 — B0210 Extraocular Extension of
Uveal Melanoma After Fine Needle Aspiration,
Vitrectomy, or Open Biopsy. Amy C. Schefler1, D.
Gologorsky2, B. Marr3, C. L. Shields4, I. Zeolite5,
D. H. Abramson3. 1Retina Consultants of Houston,
Houston, TX; 2Geisel School of Medicine at
Dartmouth, Hanover, NH; 3Ophthalmic Oncology,
Memorial Sloan-Kettering Cancer Center, New
York, NY; 4Oncology Service, Wills Eye Institute,
Philadelphia, PA; 5Ophthalmology, Universidad de
Mendoza, Mendoza, Argentina
4218 — B0211 A comparison of gene
expression profiling versus multiplex ligationdependent probe amplification in metastatic
risk prediction in choroidal melanoma. Sarah
E. Coupland1, B. E. Damato1, H. Kalirai1, M.
Baudo1, C. Bergstrom2, J. R. Wells2, T. Kivela3, H.
E. Grossniklaus2. 1Pathology, Univ of Liverpool/
Sydney Jones Library, Liverpool, United Kingdom;
2
Department of Ophthalmology, Emory University
School of Medicine, Atlanta, GA; 3Department
of Ophthalmology, Helsinki University Central
Hospital, Helsinki, Finland
4219 — B0212 Prognostic implications of
GEP class 2 in clinical practice: a single center
experience with 273 cases. James J. Augsburger,
Z. M. Correa. Ophthalmology, University of
Cincinnati, Cincinnati, OH
4220 — B0213 Choroidal Melanoma
pronostication: a robust and costless classifying
system. Nathalie Cassoux1, L. Desjardins1, C.
Plancher2, B. Asselain2, C. Levy-Gabrielle1, L.
Lumbroso-Le Rouic1, M. J. Rodrigues4, X. Sastre5, S.
Piperno-Neumann4, J. Couturier3. 1Ophthalmology,
Institut Curie, Paris, France; 2biostatistics, Institut
Curie, Paris, France; 3Genetics, Institut Curie, Paris,
France; 4Oncology, Institut Curie, Paris, France;
5
Pathology, Institut Curie, Paris, France *CR
4221 — B0214 Relationship between rate of
choroidal melanoma flattening following plaque
radiotherapy and GEP class of tumor cells.
Zelia M. Correa, J. J. Augsburger. Ophthalmology,
University of Cincinnati, Cincinnati, OH
4222 — B0215 The role of Osteopontin
expression in the mechanism of invasion and
metastasis potential in Uveal Melanoma. Bin
Li. Beijing Institute of Ophthalmology, Beijing
TongRen Hospital, Beijing, China
4223 — B0216 BAP1 mutations in uveal
melanoma. Anna E. Koopmans1, 2, R. M. Verdijk3,
T. van den Bosch3, M. M. van den Berg1, 2, J.
Vaarwater1, D. Paridaens4, E. Kilic1, A. de Klein2.
1
Ophthalmology, Erasmus Medical Centre,
Rotterdam, Netherlands; 2Clinical Genetics,
Erasmus Medical Centre, Rotterdam, Netherlands;
3
Pathology, Erasmus Medical Centre, Rotterdam,
Netherlands; 4The Rotterdam Eye Hospital,
Rotterdam, Netherlands
4224 — B0217 Gender differences and
estrogen and progesterone receptor expression
in uveal melanoma. Lynn Schoenfield1, T. Plesec2,
E. Downs-Kelly2, M. Aronow3, P. Carver2, R.
Tubbs2, A. D. Singh3. 1Pathology, Ohio State
University Wexner Medical Center, Columbus, OH;
2
Pathology, Cleveland Clinic, Cleveland, OH; 3Eye
Institute, Cleveland Clinic, Cleveland, OH
4225 — B0218 Detection of circulating tumor
cells in uveal melanoma using the CellSearch®
system. Martina Angi1, L. Khoja3, 4, B. E. Damato2,
P. Lorigan3, C. Dive4, S. E. Coupland1, H. Kalirai1.
1
Department of Molecular & Clinical Cancer
Medicine, University of Liverpool, Liverpool,
United Kingdom; 2Royal Liverpool University
Hospital, Liverpool, United Kingdom; 3The Christie
NHS Foundation Trust, Manchester, United
Kingdom; 4Paterson Institute for Cancer Research,
Manchester, United Kingdom
4226 — B0219 Quantification of circulating
tumour cells in patients with choroidal
melanocytic tumours: correlation with clinical
risk factors. Manuel F. Bande1, M. Santiago1,
P. Mera1, M. Blanco1, L. Muinelo-Romay3,
C. Capeans1, M. Pardo2, A. Piñeiro1. 1Ocular
Oncology Unit. Servizo de Oftalmoloxía.
Complexo Hospitalario Universitario de Santiago.
Universidade de Santiago de Compostela. Santiago
de Compostela. Spain, Santiago de Compostela,
Spain; 2Grupo Obesidómica, Laboratorio de
Endocrinología Molecular y Celular, Hospital
Clínico Universitario de Santiago (CHUS/
SERGAS), Spain, Santiago de Compostela,
Spain; 3Unit of circulating tumor cells analysis.
Traslational laboratory/ Medical Oncology
Department. Complexo Hospitalario Universitario
de Santiago de Compostela Santiago de
Compostela, Spain., Santiago de Compostela, Spain
4227 — B0220 Systemic Surveillance for
Metastases in patients with Uveal Melanoma.
Maria M. Choudhary1, A. Gupta2, J. Bena3, A.
D. Singh2. 1Internal Medicine, Cleveland Clinic
Foundation, Cleveland, OH; 2Department of
Ophthalmology, Cleveland Clinic Foundation,
Cleveland, OH; 3Quantitative Health Sciences,
Cleveland Clinic Foundation, Cleveland, OH
4228 — B0221 Detecting hepatic metastases
from ocular melanoma using MRI with a
novel designed contrast agent. Hua Yang1, H. E.
Grossniklaus1, Q. Zhang1, S. Xue2, F. Pu2, J. Qiao2,
Z. Liu2, R. C. Long3, J. Yang2. 1Ophthalmology,
Emory University Eye Center, Atlanta, GA;
2
Chemistry, Georgia State University, Atlanta, GA;
3
Radiology, Emory University, Atlanta, GA
4229 — B0222 In vivo contrast-enhanced
high-frequency ultrasonography of
experimental uveal melanoma: imaging
features and histopathologic correlations. Hans
E. Grossniklaus, S. J. Kang, Q. Zhang. Dept of
Ophthal, School of Med, Emory University, Atlanta,
GA
4230 — B0223 Enhanced Depth Imaging
Optical Coherence Tomography of Choroidal
Melanoma Before and After Plaque
Radiation Therapy. Denise S. Kim, H. Demirci.
Ophthalmology & Visual Sciences, University of
Michigan Kellogg Eye Center, Ann Arbor, MI
4231 — B0224 Enhanced Depth Imaging
Optical Coherence Tomography of Tumors of
the Retina and Choroid: Comparison to B-scan
ultrasonography. Euiyong Kweon1, 2, J. G. Frisch3,
P. G. Hovland1. 1Colorado Retinal Associates,
Denver, CO; 2Department of Ophthalmology,
Chonbuk National University Hospital, Jeonju,
Republic of Korea; 3Roocky Vista University
Medical School, Denver, CO
4232 — B0225 EDI-OCT Findings in Unilateral
Choroidal Melanocytosis with Macular
Involvement. Sruthi Arepalli, M. Pellegrini, C.
L. Shields. Ocular Oncology, Wills Eye Institute,
Philadelphia, PA
4233 — B0226 Macular Choroidal Thickness
in Uveal Melanoma Patients treated with Plaque
Radiotherapy. Ira H. Schachar, H. Demirci.
Ophthalmology, University of Michigan, Ann
Arbor, MI
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
280
Wednesday – Posters – 4234 – 4256
4234 — B0227 Radiation Therapy for Small
Choroidal Melanoma: 10-years Experience
with Palladium-103 Plaque Radiation Therapy.
Kimberly J. Chin, E. Semenova, P. T. Finger. The
New York Eye Cancer Center, New York, NY *CR
4235 — B0228 Plaque Radiation Therapy for
Large and Extra-large Choroidal Melanoma.
Ekaterina Semenova1, 2, P. T. Finger1, 2. 1Ocular
Oncology, The New York Eye Cancer Center, New
York, NY; 2Ocular Oncology, The New York Eye
and Ear Infirmary, New York, NY *CR
4236 — B0229 Proton beam radiation for the
treatment of large choroidal melanoma. Shideh
Schoenfeld. charite Berlin, ophthalmology, Berlin,
Germany
4237 — B0230 Outcomes of Choroidal
Melanomas Treated with Eye Physics® plaques: a
20-year Review. Jesse L. Berry1, S. V. Dandapani2,
M. Stevanovic3, M. Astrahan2, A. L. Murphree4, J.
W. Kim1, 4. 1Doheny Eye Institute and Department
of Ophthalmology, Keck School of Medicine of the
University of Southern California, Los Angeles,
CA; 2Department of Radiation Oncology, Keck
School of Medicine of the University of Southern
California, Los Angeles, CA; 3Harvard College,
Cambridge, MA; 4Ophthalmology, The Vision
Center at Children’s Hospital Los Angeles, Los
Angeles, CA *CR
4238 — B0231 103Pd versus 125I Plaque
Radiation Dose to Normal Ocular Structures
in the Treatment of 319 Uveal Melanomas. Di
Zhou1, 4, E. Semenova1, 3, P. Wong2, N. Kalach2, W.
Choi2, 3, P. T. Finger1, 4. 1The New York Eye Cancer
Center, New York, NY; 2Beth Israel Comprehensive
Cancer Center, New York, NY; 3The New York
Eye and Ear Infirmary, New York, NY; 4New York
University School of Medicine, New York, NY *CR
4240 — B0233 Intravitreal Bevacizumab
Therapy In the Management of Radiation
Maculopathy. Andrew W. Stacey, H. Demirci.
Ophthalmology, University of Michigan - Kellogg
Eye Center, Ann Arbor, MI
4241 — B0234 Autocrine impact of VEGF
ligands in uveal melanoma cells. Konrad R.
Koch1, D. Hos1, B. Regenfuss1, F. Bock1, J. J.
Bosch2, C. Cursiefen1, L. M. Heindl1. 1Center of
Ophthalmology, University of Cologne, Cologne,
Germany; 2Department of Internal Medicine 5,
Hematology and Oncology, University of ErlangenNuremberg, Erlangen, Germany *CR
4244 — B0237 Detection of Extrascleral
Extension in Uveal Melanoma. Christopher
Burris1, V. Papastefanou2, 3, C. Thaung4, M. S.
Sagoo2, 3, V. Cohen2, 3. 1Ophthalmology, Howard
University College of Medicine, Washington, DC;
2
Ocular Oncology, St. Bartholomew’s Hospital,
London, United Kingdom; 3Ocular Oncology,
Moorfields Eye Hospital, London, United Kingdom;
4
Eye Pathology, UCL Institute of Ophthalmology,
London, United Kingdom
4245 — B0238 Extraocular extension in uveal
melanoma. Jackelien van Beek1, A. E. Koopmans1, 2,
J. Vaarwater2, A. de Klein2, R. M. Verdijk3, E.
Kilic1, 2. 1Ophthalmology, Erasmus MC Rotterdam,
Rotterdam, Netherlands; 2Clinical Genetics,
Erasmus MC Rotterdam, Rotterdam, Netherlands;
3
Pathology, Erasmus MC Rotterdam, Rotterdam,
Netherlands
4246 — B0239 Ciliary Body and Choroidal
Pseudomelanoma from Hypermature Cataract
in 20 Cases. Marco Pellegrini, C. L. Shields, B.
E. Kligman, C. G. Bianciotto, J. Shields. Ocular
Oncology Service, Wills Eye Institute, Philadelphia,
PA
4247 — B0240 Prevalence of Asteroid Hyalosis
in Human and Canine Melanoma Eyes.
Heather Potter1, M. Rezaei Kanavi1, 2, A. Azari1,
R. R. Dubielzig1, D. M. Albert1. 1Ophthalmology,
University of Wisconsin, Madison, WI; 2Ophthalmic
Research Center, Shahid Beheshti University of
Medical Sciences, Tehran, Islamic Republic of Iran
*CR
4248 — B0241 Pain as presenting feature of
uveal melanoma. Pukhraj Rishi1, 2, C. L. Shields1,
K. A. Patrick1, M. A. Khan1, J. Shields1. 1Ocular
Oncology Service, Wills Eye Institute, Philadelphia,
PA; 2Sankara Nethralya, Chennai, India
4249 — B0242 Analysis of the quality of life
of patients receiving conservative treatment for
uveal melanoma. Federica Genovesi-Ebert1, C.
Meo2, F. Perrone3, C. Meo2, F. Cresti1, P. Ferrazza2,
S. Rizzo1. 1U.O. Chirurgia Oftalmica, Azienda
Ospedaliera Universitaria Pisana, Livorno, Italy;
2
Radiotherapy Department, Azienda Ospedaliera
Universitaria Pisana, Pisa, Italy; 3Sanitary Physics,
Azienda Ospedaliera Universitaria Pisana, Pisa,
Italy
4242 — B0235 Symptomatic Macular
Melanocytic Lesions Treated with Intravitreal
Bevacizumab. Jella A. An1, C. Corriveau2, M.
Sebag1, 2, S. A. Callejo1, 2. 1Ophthalmology, McGill
University, Montreal, QC, Canada; 2Ophthalmology,
Centre Hospitalier de l’Université de Montréal,
Montreal, QC, Canada *CR
Exhibit Hall B0287-B0320
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics
417 Accommodation and Presbyopia
Correction
Moderators: Abhiram S. Vilupuru and
Fabrice Manns
4250 — B0287 The Influence of Multifocal
Lenses on Fine Motor Tasks. Rupal LovellPatel1, 2, M. A. Timmis2, S. Pardhan2, P. McCarthy1, 2.
1
Vision and Hearing Sciences, Anglia Ruskin
University, Cambridge, United Kingdom; 2Vision
and Eye Research Unit, Anglia Ruskin University,
Cambridge, United Kingdom
4251 — B0288 Accommodative Lag, Facility
and Phoria with Multifocal Contact Lenses.
Jiyoon Chung1, R. C. Bakaraju1, C. Fedtke1, J.
Ozkan1, K. Ehrmann1, 2, D. Falk1, A. Ho1, 2, B. A.
Holden1, 2. 1Brien Holden Vision Institute, Sydney,
NSW, Australia; 2School of Optometry and Vision
Science, University of New South Wales, Sydney,
NSW, Australia *CR, f
4252 — B0289 The role of eye dominance
on through-focus visual performance in
modified monovision presbyopic corrections.
Len Zheleznyak1, 2, A. Alarcon2, K. C. Dieter3,
D. Tadin3, 2, G. Yoon2, 1. 1The Institute of Optics,
University of Rochester, Rochester, NY; 2Flaum
Eye Institute, University of Rochester, Rochester,
NY; 3Brain and Cognitive Sciences, University of
Rochester, Rochester, NY *CR
4253 — B0290 Customizing depth of focus
outcomes in Hyperopic Lasik using an Adaptive
Optics Vision Analyzer. Guillermo M. Perez1, E.
A. Villegas2, B. Leray3, F. J. Malecaze3, P. Artal2.
1
Voptica S.L., Murcia, Spain; 2Laboratorio de
Optica, Universidad de Murcia, Murcia, Spain;
3
Service d’Ophtalmologie, CHU Toulouse-Purpan,
Toulouse, France *CR
4254 — B0291 Effect of Age on Amplitude of
Accommodation in Bolivia. Magnus Andersson,
B. Theagarayan. Section of Optometry and Vision
Science, Linnaeus University, Kalmar, Sweden
4255 — B0292 Influences of cycloplegia
with topical cyclopentolate on higher-order
aberrations in myopic children. Takahiro
Hiraoka1, K. Miyata2, F. Okamoto1, T. Oshika1.
1
Dept of Ophthalmology, University of Tsukuba,
Tsukuba, Japan; 2Miyata Eye Hospital, Miyakonojo,
Japan
4256 — B0293 Five-year Incidence of Loss
of Accommodative Ability in the Beaver
Dam Offspring Study. Dayna S. Dalton, K. J.
Cruickshanks, M. E. Fischer, B. E. Klein, R. Klein,
A. A. Pinto. Ophthalmology and Visual Sciences,
University of Wisconsin, Madison, WI
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
281
Wednesday Posters
8:30 am – 10:15 am
4239 — B0232 High Dose Rate Interstitial
Radiation Therapy for Orbital Melanoma.
Paul T. Finger1, 3, L. B. Tena2, P. Aridgides2, E.
Semenova1, 3, W. Choi2, 3. 1Ophthalmic Oncology,
The New York Eye Cancer Center, New York, NY;
2
Radiation Oncology, Beth Israel Comprehensive
Cancer Center, New York, NY; 3Ophthalmology,
The New York Eye and Ear Infirmary, New York,
NY *CR
4243 — B0236 Minimally invasive therapy
of exudative retinal detachment (ERD) due
to choroidal or ciliary body melanoma after
irradiation therapy compared to endoresection.
Ira Seibel1, D. Cordini2, G. Willerding-Beaucamp1,
J. Heufelder2, A. M. Joussen1. 1Department of
Ophthalmology, Charité University Medicine,
Berlin, Germany; 2Proton beam therapy, HelmholtzZentrum Berlin für Materialien und Energie - LiseMeitner-Campus, Berlin, Germany
4257 – 4279 – Wednesday – Posters
4257 — B0294 Effect of Unclean Display on
Accommodative Response. Masakazu Hirota1, H.
Uozato1, 2, S. Arai1, Y. Shibata1. 1Ophthalmology &
Visual Sciences, Kitasato Univ Graduate School,
Minami-ku, Sagamihara-shi, Japan; 2Orthoptics
& Visual Sciences, Kitasato University School of
Allied Health Science, Minami-ku, Sagamihara-shi,
Japan
4265 — B0302 Do Higher Order Aberrations
Affect the Magnitude of Odd-error Temporal
Stimuli to Accommodation? Sangeetha
Metlapally1, J. Tong2, H. J. Tahir3, 1, C. M. Schor1.
1
School of Optometry, University of California at
Berkeley, Berkeley, CA; 2Brain Trauma Foundation,
New York, NY; 3University of Manchester,
Manchester, United Kingdom
4258 — B0295 The effect of near addition
lenses on the accuracy of the accommodative
response in myopic children during reading.
Jinhua Bao, Z. Zheng, H. Chen. School of
Optometry and Ophthalmology, Wenzhou Medical
College, Wenzhou, China
4266 — B0303 Impact of pupil amplitude
apodization on through-focus image quality
with spherical aberration. Hae Won Jung1, 2, L.
Zheleznyak1, 2, G. Yoon2, 1. 1The Institute of Optics,
University of Rochester, Rochester, NY; 2Flaum
Eye Institute, University of Rochester, Rochester,
NY *CR
4259 — B0296 Tonic Accommodation
Correlates with Accommodative AmplitudeScaled Facility Test for Symptomatic Graduate
Students. Chunming Liu1, C. Chase1, S. A. Drew3,
E. Castellanos1, A. Escobar1, E. Borsting2, L.
R. Stark2. 1Optometry, Western University of
Health Sciences College of Optometry, Pomona,
CA; 2Southern California College of Optometry,
Fullerton, CA; 3California State University,
Northridge, Northridge, CA
Wednesday Posters
8:30 am – 10:15 am
4260 — B0297 Larger Tonic Accommodation
Correlates with Better Focus at Near for
Symptomatic Graduate School Students. Chris
Chase1, S. A. Drew3, A. Escobar1, C. Liu1, E.
Castellanos1, L. R. Stark2, E. Borsting2. 1College of
Optometry, Western University of Health Sciences,
Pomona, CA; 2Southern California College of
Optometry, Fullerton, CA; 3California State
University, Northridge, Northridge, CA f
4261 — B0298 The Dynamic Accommodative
Response with the Binocular open-field
autorefractor and a Movable Real Target. Shinji
Arai1, H. Uozato1, 2, M. Hirota1. 1Department of
Visual Science, Kitasato University Graduate
School of Medical Sciences, Kanagawa, Japan;
2
Department Orthoptics and Visual Sciences,
Kitasato University School of Allied Health
Science, Kanagawa, Japan
4262 — B0299 Suppression in the
accommodative response to short-duration
changes in dioptric stimulus. Alistair P. Curd,
K. M. Hampson, E. Mallen. Bradford School of
Optometry and Vision Science, University of
Bradford, Bradford, United Kingdom
4263 — B0300 Accommodation induced
variations of ocular axial length and retinal
thickness measured with SD-OCT. Chuanqing
Zhou, S. Fan, Z. Chen, X. Chai. Biomedical
Engineering, Shanghai Jiao Tong University,
Shanghai, China
4264 — B0301 The Effect Of Age On The
Lens Ultrastructure During Accommodation As
Measured Using Slit Lamp Photos And Wave
Front Analysis. Rebecca K. Zoltoski1, E. Wyles1,
J. S. Harthan1, J. R. Kuszak2. 1Illinois College of
Optometry, Chicago, IL; 2LensAR, Orlando, FL
*CR
4267 — B0304 Contribution of shape and
gradient index to the spherical aberration of
donor human lenses. Judith Birkenfeld, A. de
Castro, S. Marcos. CSIC-Instituto de Optica,
Madrid, Spain *CR
4268 — B0305 Crystalline lens thickness
determines transverse chromatic aberration. Yun
Chen, F. Schaeffel. Section of neurobiology of the
Eye, Institute for Ophthalmic Research, Tuebingen,
Germany
4269 — B0306 Prediction of human crystalline
lens power and spherical aberration using an
anatomically-based discrete shell model. Fabrice
Manns1, 2, A. Ho3, 4, J. A. Parel1, 5. 1Ophthalmic
Biophysics Center, Bascom Palmer Eye Inst, Univ
of Miami, Miami, FL; 2Department of Biomedical
Engineering, University of Miami College of
Engineering, Coral Gables, FL; 3Brien Holden
Vision Institute, Sydney, NSW, Australia; 4School
of Optometry and Vision Science, University of
New South Wales, Sydney, NSW, Australia; 5Vision
Cooperative Research Centre, Sydney, NSW,
Australia *CR
4270 — B0307 Age-related Stiffening of
Human Lens Measured by In Vivo Brillouin
Microscopy. Sebastien Besner1, 2, G. Scarcelli1, 2, R.
Pineda3, S. H. Yun1, 2. 1Department of Dermatology,
Harvard Medical School, Boston, MA; 2Wellman
Center for Photomedicine, Massachusetts
General Hospital, Boston, MA; 3Department
of Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA *CR
4271 — B0308 Effect of Temperature on
Lens Power, Anterior and Posterior Surface
Lens Curvatures and Force during Simulated
Accommodation in Cynomolgus Monkeys. JeanMarie A. Parel1, 3, B. M. Maceo1, 2, C. J. Rowaan1,
F. Manns1, 2, E. Arrieta1. 1Ophthalmic Biophysics
Center, Bascom Palmer Eye Institute, Univ. of
Miami Miller School of Medicine, Miami, FL;
2
Biomedical Optics and Laser Laboratory, Dept of
Biomedical Engineering, College of Engineering,
University of Miami, Miami, FL; 3Vision
Cooperative Research Centre, Sydney, NSW,
Australia *CR
4272 — B0309 Lens Spherical Aberration
Changes in Cynomolgus Monkeys during
Simulated Accommodation in a Lens Stretcher.
Bianca M. Maceo1, 2, F. Manns1, 2, A. de Castro3, S.
Uhlhorn1, E. Arrieta1, S. Marcos3, J. A. Parel1, 4.
1
Ophthalmic Biophysics Center, Bascom Palmer
Eye Institute, Miami, FL; 2Biomedical Optics
and Laser Laboratory, Department of Biomedical
Engineering, University of Miami College of
Engineering, Coral Gables, FL; 3Instituto de Óptica,
Consejo Superior de Investigaciones Científicas,
Madrid, Spain; 4Vision Cooperative Research
Centre, Sydney, NSW, Australia *CR
4273 — B0310 Comparison between in vivo
and in vitro age-related loss of accommodation in
rhesus monkeys. Mark Wendt, A. Glasser. College
of Optometry, University of Houston, Houston, TX
4274 — B0311 Age-related loss of
accommodation in rhesus monkeys is associated
with an age-related increase in lens stiffness.
Adrian Glasser, M. Wendt. College of Optometry,
University of Houston, Houston, TX
4275 — B0312 Dynamic wavefront
measurement of accommodation and pupil area
in response to electric stimulation of ciliary
nerve in cats. Suguru Miyagawa1, 2, T. Mihashi2, 4,
Y. Hirohara1, 2, A. Takada1, T. Endo2, H. Kanda2,
T. Miyoshi3, T. Fujikado2. 1Optical Engineering
Laboratory, Topcon Corporation, Itabashi-Ku,
Japan; 2Dept of Applied Visual Science, Osaka
University Graduate School of Medicine, Suita,
Japan; 3Integrative Physiology, Osaka University
Graduate School of Medicine, Suita, Japan;
4
Innovative Research Initiatives, Tokyo Institute of
Technology, Yokohama, Japan *CR
4276 — B0313 Macular function contributes
to the near vision performance in the patients
with monofocal intraocular lens: a functional
Multifocal ERG study. Xialin Liu, Y. Ni, C. He, L.
Wang, Y. Liu. Zhongshan Ophthalmic Center, Sun
Yat-sen University, Guangzhou, China
4277 — B0314 Changes in Add Power for Near
Vision after Laser in Situ Keratomileusis for
Presbyopic High Myopia. Yukari Tsuneyoshi1, 3, K.
Negishi1, M. Yoshida1, M. Saiki1, N. Kato1, I. Toda2,
K. Tsubota1. 1Ophthalmology, Keio University
School of medicine, Tokyo, Japan; 2Ophthalmology,
Minamiaoyama Eye Clinic, Tokyo, Japan;
3
Ophthalmology, Tachikawa Hospital, Tachikawa,
Japan *CR
4278 — B0315 Subsurface Femto-Laser
Photodisruption in the Sclera for the Creation
of Presbyopic Implant Tunnels. Aghapi
Mordovanakis1, 2, L. Baitch3. 1Biomedical
Engineering, University of Michigan, Ann
Arbor, MI; 2Center for Ultrafast Optical Science,
University of Michigan, Ann Arbor, MI; 3Research,
Refocus Group, Dallas, TX *CR
4279 — B0316 Electro-optic lens for correction
of presbyopia. Guoqiang Li, T. F. Mauger. Depts
of Ophthal and Vis Sci and ECE, Ohio State
University, Columbus, OH *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
282
Wednesday – Posters – 4280 – 4301
4280 — B0317 Tolerance to astigmatism
with a small aperture corneal inlay. Abhiram
S. Vilupuru1, J. Tabernero2, P. Artal2. 1R&D,
AcuFocus, Inc, Irvine, CA; 2Universidad de Murcia,
Murcia, Spain *CR
4281 — B0318 Distribution of Achromatizing
Pupil Positions and First Purkinje Reflections
in a Normal Population. Silvestre Manzanera1,
J. Tabernero1, A. Benito1, A. S. Vilupuru2, P. M.
Prieto1, P. Artal1. 1Laboratorio de Optica, University
of Murcia, Murcia, Spain; 2R&D, AcuFocus, Irvine,
CA *CR
4282 — B0319 Visual Simulation of Retinal
Images with Various Designs of Pinhole Contact
Lenses using Ray Tracing Software. Kazuno
Negishi1, Y. Nishi1, K. Ohnuma2, K. Tsubota1.
1
Department of Ophthalmology, Keio Univ School
of Medicine, Shinjuku-Ku, Japan; 2Graduate School
of Engineering, Chiba Univesity, Chiba, Japan *CR
4283 — B0320 Visual Simulation of Retinal
Images with Various Designs of Pinhole
Contact Lenses. Yasuyo Nishi, K. Negishi, K.
Watanabe, Y. Hidaka, H. Torii, M. Saiki, K.
Tsubota. Ophthalmology, Keio University School of
Medicine, Tokyo, Japan *CR
Exhibit Hall C0022-C0045
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Physiology/Pharmacology / Cornea
418 Antibiotics and Corneal Disease
Moderator: Haydee E. Bazan
4285 — C0023 Susceptibility of
Stenotrophomonasmaltophilia to Antibiotics
and Contact Lens Multipurpose Solutions. Keizo
Watanabe1, 2, H. Zhu2, R. Bandara2, S. Higaki1,
M. Fukuda1, Y. Shimomura1, M. D. Willcox2, B. A.
Holden1. 1Ophthalmology, Kinki University Faculty
of Medicine, Osakasayama, Japan; 2Brien Holden
Vision Institute, Sydney, NSW, Australia *CR
4286 — C0024 A Comparison of Prophylactic
Antibacterial Efficacy of Besifloxacin 0.6% versus
Moxifloacin 0.5% at 1 hour and 3 days Prior to
Phacoemulsification. Frank A. Bucci. Bucci Laser
Vision Institute, Wilkes-Barre, PA *CR, f
4287 — C0025 Cytotoxicities of various
ophthalmic antimicrobial solutions in SV40immortalized human corneal epithelial cells. Jae
Lim Chung1, S. Song1, B. Kim1, J. H. Lee2, K. Seo3.
1
Konyang University Kim’s Eye Hospital, Seoul,
Republic of Korea; 2Myunggok Eye Research
Institute, Konyang University, Seoul, Republic
of Korea; 3Shinchon Severance Hospital, Yonsei
University, Seoul, Republic of Korea
4289 — C0027 Tear Osmolarity in Pediatric
Patients with Cystic Fibrosis. Livio Giulio Marco
Franco1, V. De Grande1, S. Stella1, M. Reibaldi1,
E. Lionetti2, C. Franzonello2, S. Leonardi2, C.
Gagliano1, A. Russo1, M. La Rosa2. 1Institute of
Ophthalmology, University of Catania, Catania,
Italy; 2Department of Pediatrics, University of
Catania, Catania, Italy
4290 — C0028 The Pharmacokinetics and
Aqueous Humor Penetration of Besifloxacin
0.6% and Moxifloxacin 0.5% in Patients
Undergoing Cataract Surgery. Ruth Evans, F. A.
Bucci. Bucci Laser Vision Institute, Wilkes Barre,
PA *CR, f
4291 — C0029 Ocular Pharmacokinetics,
Safety and Efficacy of Intracameral Moxifloxacin
0.5% Solution in a Rabbit Model. Yonca Akova1, 2,
L. Asena2, M. T. Göktas5, A. Bozkurt5, U. Yasar5,
G. Karabay4, E. Demiralay3. 1Ophthalmology,
Bayindir Kavaklidere Hospital, Ankara, Turkey;
2
Ophthalmology, Baskent University Faculty of
Medicine, Ankara, Turkey; 3Pathology, Baskent
University Faculty of Medicine, Ankara, Turkey;
4
Histology, Baskent University Faculty of Medicine,
Ankara, Turkey; 5Pharmacology, Hacettepe
University Faculty of Medicine, Ankara, Turkey
4292 — C0030 High affinity LPS-binding
branched peptides display synergistic
activity with other antibiotics. Rajamani
Lakshminarayanan1, 2, S. Liu1, 2, R. W. Beuerman1, 2.
1
Singapore Eye Research Institute, Singapore,
Singapore; 2SRP Iin Neuroscience and Behavioral
Disorders, Duke-NUS Graduate Medical School,
Singapore, Singapore *CR
4293 — C0031 The Comparison of Topical
RPX-978 (an Ophthalmic Formulation of
Tigecycline) to Topical Vancomycin in a MRSA
Rabbit Keratitis Model. Eric G. Romanowski, K.
A. Yates, K. E. O’Connor, F. S. Mah, L. Raju, R. M.
Shanks, R. P. Kowalski. The Charles T. Campbell
Laboratory, UPMC Eye Center, University of
Pittsburgh, Pittsburgh, PA *CR
4294 — C0032 The Monthly Eye Drop:
Development of a Long-term, Noninvasive
Glaucoma Treatment System. Morgan V.
Fedorchak1, 2, A. Cugini1, J. S. Schuman1, 3, S. R.
Little1, 2. 1University of Pittsburgh, Pittsburgh, PA;
2
McGowan Institute for Regenerative Medicine,
Pittsburgh, PA; 3UPMC Eye Center, Pittsburgh, PA
*CR
4295 — C0033 Chronic alcohol consumption
and corneal pathologies: the role of aldehyde
dehydrogenases. Naseem Ansari1, 2, M. Zhang1,
C. Wang1, J. Papaconstantinou1, V. Vasiliou3, B.
Kaphalia4. 1Biochemistry and Molecular Biology,
University of Texas Medical Branch, Galveston,
TX; 2Ophthalmology & Visual Science, University
of Texas Medical Branch, Galveston, TX;
3
Pharmaceutical Sciences, University of Colorado,
Aurora, CO; 4Pathology, University of Texas
Medical Branch, Galveston, TX
4296 — C0034 Small non-hydrophobic,
cationic peptide with in vitro and in vivo efficacy
against Gram negative bacteria. Roger W.
Beuerman1, S. Liu2, R. Lakshminarayanan3, J. Li4,
B. Yang5. 1Singapore Eye Research Inst, Singapore,
Singapore; 2Singapore Eye Research Institute,
Singapore, Singapore; 3Singapore Eye Research
Institute, Singapore, Singapore; 4Singapore
Eye Research Institute, Singapore, Singapore;
5
Singapore Eye Research Institute, Singapore,
Singapore *CR
4297 — C0035 Molecular Design of Novel
Membrane Targeting Antimicrobials with
Improved Membrane Selectivity Using Natural
Compound as a Scaffold. Shouping Liu1, 2, H.
Zou1, J. Koh1, J. Li3, R. Lakshminarayanan1, 2, R.
W. Beuerman1, 2. 1Singapore Eye Research Institute,
Singapore, Singapore; 2Duke-NUS Medical School,
SRP Neuroscience and Behavioural Disorders,
Singapore 169857, Singapore, Singapore;
3
Bioinformatics Institute, Singapore 138671,
Singapore, Singapore *CR
4298 — C0036 In vitro analysis of the effect
of steroid in combination with antimicrobial on
co-cultures of bacteria and fungi isolated from
keratitis. Herlinda Mejia-Lopez1, L. Y. MartínezLópez2, A. Clinent-Flores1, A. V. Rodríguez-Tovar2,
L. A. Bautista-Hernández1, V. M. Bautista de
Lucio1, M. A. Martínez-Rivera2. 1Research Unit,
Inst of Ophthal “Conde de Valenciana”, Mexico
City, Mexico; 2Laboratory of Medical Mycology,
Department of Microbiology, National School of
Biological Sciences, Instituto Politécnico Nacional,
México, Mexico
4299 — C0037 Iontophoresis transcorneal
delivery technique for transepithelial corneal
collagen crosslinking with riboflavin in a
rabbit model. Vincent J. Soler1, 2, M. Cassagne1, 2,
C. Laurent3, A. Galinier4, P. R. Fournie1, 2, S.
Galiacy1, P. Roy5, F. J. Malecaze1, 2. 1UMRS 563,
CPTP, Universite Paul Sabatier, Toulouse, France;
2
Ophthalmology, Toulouse Purpan Hospital,
Toulouse, France; 3Laboratory of Pathology,
Toulouse Purpan Hospital, Toulouse, France;
4
Department of Biochemistry, Toulouse Rangueil
Hospital, Toulouse, France; 5Hexamed, Paris,
France *CR
4300 — C0038 Comparative Analysis
of In Vitro Biocompatibility Assays of
Polyhexamethylene Biguanide Disinfecting
Contact Lens Multi-Purpose Solutions. Mercedes
Salvador-Silva1, L. C. Huang1, J. Cook2. 1Biology
R&D, Abbott Medical Optics (AMO), Santa Ana,
CA; 2Corneal Product Development R&D, Abbott
Medical Optics (AMO), Santa Ana, CA *CR
4301 — C0039 Benzalkonium Chloride
Stimulation of THP-1 Differentiated
Macrophages in Vitro. Sylvain Michee1, 2, F.
Brignole-Baudouin2, L. Riancho2, W. H. Rostene2,
C. Baudouin1, 2, A. Labbe1, 2. 1department 3, CHNO
des 15-20, Paris, France; 2UMRS 968, vision
institute, PARIS, France
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
283
Wednesday Posters
8:30 am – 10:15 am
4284 — C0022 The use of predatory
prokaryotes to control human ocular pathogens.
Robert M. Shanks1, K. To2, N. A. Stella1, K. M.
Brothers1, R. P. Kowalski1, E. G. Romanowski1,
D. E. Kadouri2. 1Ophthalmology, University of
Pittsburgh, Pittsburgh, PA; 2Oral Biology, UMDNJ,
Newark, NJ *CR
4288 — C0026 The In Vitro Activity of
Tigecycline for Clinically Relevant Ocular
Pathogens. Regis P. Kowalski, T. Kowalski,
E. G. Romanowski, R. M. Shanks, L. Raju.
Ophthalmology/Microbiology, Univ of Pittsburgh,
Pittsburgh, PA *CR
4302 – 4321 – Wednesday – Posters
4302 — C0040 Delayed corneal wound
healing resulting from the administration
of fluoroquinolone antibacterial ophthalmic
solutions and its causes. Masamichi Fukuda, Y.
Seki, Y. Kurihara, S. Enta, N. Shibata, K. Hagiwara,
H. Osada, S. Shibata, E. Kubo, H. Sasaki.
Ophthalmology, Kanazawa Medical University,
Uchinada, Japan
4303 — C0041 Penetration of Eye Drop
Solutions of Fluoroquinolones into the Cornea
and Anterior Chamber of Human Enucleated
Eyes. Sidney J. Sousa, G. C. Mendonça.
Ophthalmology, Univ of Sao Paulo-Sch of Med,
Ribeirao Preto, Brazil
4304 — C0042 To evaluate the efficacy of
corneal collagen crosslinking in fungal corneal
ulcers. Shah Nawaz, P. K. Maharana, N. Sharma,
R. B. Vajpayee. Opthalmology, R.P.Centre, AIIMS,
New Delhi, India
4305 — C0043 Improvement of post-cataract
dry eye by 0.05% cyanocobalamine plus 0.5%
taurine and 0.5% long-chained hyaluronic acid.
Federico Solignani1, M. Zurria2, M. Rolando1,
3 1
. Ophthalmology Dept - Ocular surface disease
research center, University of Genoa, Genoa, Italy;
2
Medical Dept, Alfa Intes Ind Ter Spl srl, Casoria,
Italy; 3Is.Pre Oftalmica, Genoa, Italy *CR
Wednesday Posters
8:30 am – 10:15 am
4306 — C0044 Title: Susceptibility Profiles
in Infectious Keratitis as an Aid in Antibiotic
Selection. Mark L. Hill, D. A. Friedman, E. Cooper,
J. Parker. Ophthalmology, UAB, Homewood, AL
4307 — C0045 Photodynamic antimicrobial
chemotherapy for methicillin-resistant
Staphylococcus aureus -in vitro, biofilm, and ex
vivo bovine keratitis model. Hsiao-sang Chu1, F.
Hu1, C. Chen2, 3. 1Department of Ophthlamology,
National Taiwan University Hospital, Taipei,
Taiwan; 2Center for Optoelectronic Biomedicine,
College of Medicine, National Taiwan University,
Taipei, Taiwan; 3Institute of Microbiology and
Biochemistry, College of Life Science, National
Taiwan University, Taipei, Taiwan
Exhibit Hall C0046-C0100
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Cornea
419 Dry Eye and Lacrimal Gland IV
Moderator: Benjamin D. Sullivan
4308 — C0046 Tear specific potential protein
biomarker identification by 2D-DIGE based
proteomics in Dry eye syndrome associated
with Rheumatoid Arthritis. Narayanasamy
Angayarkanni1, S. Venkata Aluru2, U. Tatu3, S.
Agarwal4, B. Srinivasan5, G. Krishnan Iyer6, S.
M. Rajappa7, U. Vetrivel8, P. Padmanabhan9.
1
Biochemistry and Cell Biology, Vision Research
Foundation, Chennai, India; 2Biochemistry
and Cell Biology, Vision Research Foundation,
Chennai, India; 3Biochemistry Dept, Indian
Institute of Science, Bangalore, India; 4Ocular
Surface Clinic, Medical Research Foundation,
Chennai, India; 5Ocular Surface Clinic, Medical
Research Foundation, Chennai, India; 6Ocular
Surface Clinic, Medical Research Foundation,
Chennai, India; 7Cerebrovascular and Vasculitis
Research Foundation, Chennai, India; 8Centre
for Bioinformatics, Vision Research Foundation,
Chennai, India; 9Cornea Services, Medical Research
Foundation, Chennai, India
4309 — C0047 The Correlation of Muc-16 as
compared to Dry Eye Clinical Endpoints in Dry
Eye and Normal Subjects. Michael Watson, K. J.
Lane, A. Whitlock, G. W. Ousler. Ora, Inc., Andover,
MA *CR
4310 — C0048 The Use of Soluble Muc-16
(CA-125) as a Clinically Relevant Biomarker and
Endpoint in a Mouse Model of Dry Eye. Jennifer
Brackett, L. Belen, K. Violette, A. Whitlock. Ora,
Inc., Andover, MA *CR
4311 — C0049 Megalin and Cubilin Levels are
Altered in Tear-Producing Glands of Vitamin D
Receptor Null Mice. Xiaowen Lu, M. A. Watsky.
Department of Physiology, University of Tennessee
Health Science Center, Memphis, TN
4312 — C0050 Changes in corneal nerve
morphology and epithelial wound healing
after prolonged ocular dryness induced by
lacrimal gland ablation. Kamila Mizerska1, N.
Cuenca2, C. Luna1, S. Quirce1, L. FernandezSanchez2, I. Kovacs3, M. Acosta1, C. Belmonte1, J.
Gallar1. 1Instituto de Neurociencias, Universidad
Miguel Hernandez-CSIC, San Juan de Alicante,
Spain; 2Departamento de Fisiología, Genética y
Microbiología, Universidad de Alicante, Alicante,
Spain; 3Department of Ophthalmology, Semmelweis
University, Budapest, Hungary *CR
4313 — C0051 Isolation and characterization
of progenitor cells from intact rabbit lacrimal
gland. Hong He1, G. Sun1, H. Lin1, M. A. Shatos2,
D. A. Dartt2, S. C. Yiu1, 3. 1Wilmer Eye Institute,
Baltimore, MD; 2Shepens Eye Research Institute,
Boston, MA; 3King Khaled Eye Specialist Hospital,
Riyadh, Saudi Arabia
4314 — C0052 Alterations of Tear Functions
and Ocular Surface Epithelial Differentiation in
the SOD-1 Knock- out Mouse. Murat Dogru1, 2, T.
Kojima2, 1, T. Nagata2, 1, A. Igarashi1, 2, K. Higa1, 2,
Y. Satake1, S. Shimazaki1, S. Takahiko3, K. Tsubota2,
1
, J. Shimazaki1. 1Ophthalmology, Tokyo Dental
College, Ichikawa, Japan; 2Ophthalmology, Keio
University School of Medicine, Tokyo, Japan;
3
Institute of Aging, Chiba University School of
Medicine, Chiba, Japan *CR
4315 — C0053 L-carnitine, Erythritol and
Betaine Suppress the Production and Activity
of Matrix Metalloproteinases in Primary
Human Corneal Epithelial Cells Exposed to
Hyperosmotic Stress. Ruzhi Deng1, 2, Z. Su1, 2, J.
Lin1, X. Hua1, D. Li1, S. C. Pflugfelder1. 1Department
of Ophthalmology, Baylor College of Medicine,
Houston, TX; 2Optometry and Ophthalmology,
Wenzhou Medical College, Wenzhou, China *CR
4316 — C0054 Suppressive effects of
17β-estradiol on immortalized human
meibomian gland epithelial cells. Wendy R. Kam,
D. A. Sullivan. Schepens Eye Research Institute,
Massachusetts Eye and Ear, Harvard Medical
School, Boston, MA *CR
4317 — C0055 Impact of azithromycin on
lipid accumulation in immortalized human
meibomian gland epithelial cells. Yang Liu, W.
R. Kam, J. Ding, D. A. Sullivan. Schepens Eye
Research Institute, Massachusetts Eye and Ear,
Harvard Medical School, Boston, MA *CR
4318 — C0056 A Comparative Evaluation of
Lipid-based Formulations for Dry-Eye Therapy
using a Corneal Epithelial Cell Desiccation
Model and Physicochemical Measurements.
Paramita Sarkar, Z. Marlowe, A. Walsh, B. Glass,
T. Kleiber, M. E. Cavet, K. L. Harrington, S. Davio.
R&D, Bausch & Lomb, Rochester, NY *CR
4319 — C0057 Early Clinical Development
of EBI-005, a Potent Interleukin-1 (IL-1)
Receptor-1 (R1) Blocker for Topical Ocular
Treatment of Dry Eye Disease (DED). Michael H.
Goldstein1, 2, G. Zarbis-Papastoitsis2, K. Golden2,
S. Chowdhury2, C. Wheeler2, G. N. Foulks3,
J. T. Kovalchin2, J. Agahigian2, E. S. Furfine2.
1
Ophthalmology, New England Eye Center,
Boston, MA; 2Eleven Biotherapeutics, Cambridge,
MA; 3Ophthalmology, University of Louisville,
Louisville, KY *CR, f
4320 — C0058 Preclinical Development of EBI005: a Potent Interleukin-1 (IL-1) Receptor-1
(R1) Blocker for Topical Ocular Administration
was Safe in GLP Toxicology Studies and Active
in a Mouse Model of Dry Eye Disease (DED).
Eric S. Furfine1, K. Collins1, D. Escobar3, C. Li2, P.
A. Lowden1, A. Masci1, J. Milling1, K. Tenneson2,
G. Wolfe4, J. T. Kovalchin1. 1R&D, Eleven
Biotherapeutics, Cambridge, MA; 2Charles River
Laboratories, Senneville, QC, Canada; 3Intertek,
San Diego, CA; 4Gary Wolfe Toxicology LLC,
Herndon, VA *CR
4321 — C0059 Soft steroid topical treatment
for moderate to severe dry eye: pulse vs tapered
therapy. Edoardo Villani, C. Pirondini, F. Viola, R.
Ratiglia. UO Oculistica, Univ of Milan Fnd IRCCS
Ca’ Granda OMP, Milan, Italy
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
284
Wednesday – Posters – 4322 – 4345
4322 — C0060 Comparison of Three
Commercially Available Tear Substitutes
Designed for Evaporative Dry Eye Treatment.
Charles G. Connor, R. A. Ottenbreit, L. K.
Schroeder, J. C. Rabin, S. Narayanan. Rosenberg
School of Optometry, University of the Incarnate
Word, San Antonio, TX
4323 — C0061 Plasmacytoid Dendritic Cells
are the Primary Source of IFN-α During the
Immunopathogenesis of Desiccating StressInduced Dry Eye Disease. Michael E. Stern1, C.
S. Schaumburg1, J. Gao1, A. M. Ratanapinta1, V.
L. Calder2, L. A. Wheeler1, J. Y. Niederkorn3, S.
C. Pflugfelder4, B. Beutler5, A. N. Theofilopoulos6.
1
Biological Sciences, Allergan, Inc, Irvine, CA;
2
Ophthalmology, University College London,
London, United Kingdom; 3Ophthalmology,
University of Texas Southwestern Medical School,
Dallas, TX; 4Ophthalmology, Baylor University
College of Medicine, Houston, TX; 5Center for
the Genetics of Host Defense, University of
Texas Southwestern Medical School, Dallas,
TX; 6Immunology & Microbial Science, Scripps
Research Institute, La Jolla, CA *CR
4324 — C0062 Analysis of Tear Inflammatory
Mediators: A comparison of Microarray and
Luminex In Differing Subject Groups. Karen
Dionne, K. K. Nichols, A. M. McDermott, R. L.
Redfern, J. J. Nichols. College of Optometry,
University of Houston, Houston, TX *CR
4325 — C0063 Tear film cytokine analyses
using a novel electrochemiluminescent array
technique. Lakshman N. Subbaraman, M.
Thangavelu, D. J. McCanna, L. W. Jones. CCLR,
School of Optometry, University of Waterloo,
Waterloo, ON, Canada *CR
4327 — C0065 New recombinant hyaluronic
acid for eye care and ophthalmic drug delivery.
Birgit Lundskov Fuhlendorff, K. SchwachAbdellaoui, F. Longin, C. Eenschooten. Novozymes
Biopharma DKA/S, Bagsvaerd, Denmark *CR
4328 — C0066 Preliminary Studies Of
Liposomal Formulation Containing An
Omega-3 Fatty Acid For Dry Eye Therapy.
Marta Vicario de la Torre1, O. Avelino Cruz1,
M. Caballo Gonzalez1, B. de las Heras2, J. M.
Benitez-del-Castillo3, R. Herrero-Vanrell1, I. T.
Molina-Martínez1. 1Pharmacy and Pharmaceutical
Technology, Faculty of Pharmacy, Complutense
University, Madrid, Spain; 2Pharmacology, Faculty
of Pharmacy, Complutense University, Madrid,
Spain; 3Unidad Superficie e Inflamación Ocular,
Instituto de Investigacaión Sanitaria, Hospital
Clínico San Carlos, Madrid, Spain
4331 — C0069 Ocular Surface Disease
Characteristics in Patients with Ocular
Graft-versus-Host Disease (GVHD). Hasanain
Shikari1, 2, U. S. Saboo1, 2, R. Dana1, 2. 1Cornea and
Refractive Surgery, Massachusetts Eye and Ear
Infirmary, Harvard Medical School, Boston, MA;
2
Schepens Eye Research Institute, Harvard Medical
School, Boston, MA *CR
4332 — C0070 Relationships among Tear Film
Stability, Tear Osmolarity, Corneal Staining
History, and Dryness Symptoms. Thao N. Yeh1, N.
Tran1, A. D. Graham1, H. M. Green2, M. C. Lin1, 2.
1
Clinical Research Center, School of Optometry,
University of California, Berkeley, Berkeley, CA;
2
School of Optometry, University of California,
Berkeley, Berkeley, CA *CR
4333 — C0071 Handheld Tear Film Lipid
Layer Thickness and Non Invasive Tear Break
Up Time Assessment Tool. Igor Petricek.
Ophthalmology, Clinical Hospital Zagreb, Zagreb,
Croatia
4334 — C0072 Does the Phenol Red Thread
test and the Schirmer test measure the same
thing? J. Peter Gierow, S. Andersson. School of
Natural Science, Linnaeus University, Kalmar,
Sweden
4335 — C0073 Limbal capillary perfusion and
blood flow velocity as a potential biomarker for
evaluating dry eye. Jianhua Wang1, H. Jiang1,
A. Tao1, 2, D. DeBuc1, Y. Shao2, 1, J. Zhong3, 1, S.
Pineda1. 1Ophthalmology, Bascom Palmer Eye Inst
Lib, Miami, FL; 2Ophthalmology and Optometry,
School of Ophthalmology and Optometry, Wenzhou
Medical College, Wenzhou, China; 3Ophthalmology,
Hangzhou First People’s Hospital, Hangzhou, China
*CR
4336 — C0074 Real World Analytical
Performance of the TearLab Osmolarity System
with an Enhanced Temperature Sensor. Benjamin
D. Sullivan, S. G. Zmina, M. G. Zmina, M. S. Berg.
TearLab Corp, San Diego, CA *CR
4337 — C0075 Evaluation of the Validity of the
Diagnostic Criteria for Dry Eye in Japan Using
Subjective Symptoms: Osaka Study. Norihiko
Yokoi1, M. Uchino2, Y. Uchino2, M. Dogru2, M.
Kawashima2, A. Komuro1, Y. Sonomura1, H. Kato1,
K. Tsubota2, S. Kinoshita1. 1Ophthalmology, Kyoto
Prefectural University of Medicine, Kyoto, Japan;
2
Ophthalmology, Keio University School of
Medicine, Tokyo, Japan *CR
4338 — C0076 Progression of Ocular Findings
(PROOF) Study of the Natural History of
Dry Eye: Study Design and Baseline Patient
Characteristics. Peter J. McDonnell1, S.
Pflugfelder2, R. M. Schiffman3, D. R. Hardten4,
M. E. Stern3, T. Conway3, D. A. Hollander3.
1
Ophthalmology, Johns Hopkins Wilmer Eye Inst,
Baltimore, MD; 2Baylor College of Medicine,
Houston, TX; 3Allergan, Inc., Irvine, CA;
4
Minnesota Eye Consultants, Minneapolis, MN
*CR, f
4339 — C0077 Prevalence of dry eye subtypes and severity of evaporative dry eye using
objective tests. Milton M. Hom1, J. T. Kwan2.
1
Private Practice, Azusa, CA; 2Southern California
College of Optometry, Fullerton, CA *CR
4340 — C0078 Relating Improvements in
Signs and Symptoms to Duration of Dry Eye
Disease (DED) after Treatment with MIM-D3
Ophthalmic Solutions. Karen Meerovitch1, 3,
T. Lama1, D. A. Schaumberg2, 4. 1Mimetogen
Pharmaceuticals, Montreal, QC, Canada; 2Division
of Preventive Medicine, Brigham & Women’s
Hospital, Harvard Medical School, Boston, MA;
3
Department of Pharmacology and Therapeutics,
McGill University, Montreal, QC, Canada;
4
Department of Ophthalmology and Visual
Sciences, University of Utah School of Medicine,
Salt Lake City, UT *CR, f
4341 — C0079 Automated Detection and
Enumeration of Corneal Superficial Punctate
Keratitis. John D. Rodriguez1, P. Johnston1, K. J.
Lane1, G. W. Ousler2. 1R & D, Ora, Inc., Andover,
MA; 2Ora, Inc., Andover, MA *CR
4342 — C0080 Ocular Surface Disease
prevalence in Glaucoma patients in a High
Referral Ophthalmology Center in Mexico City.
Nallely Ramos-Betancourt1, J. D. Martinez1, F.
Beltran1, J. Ozorno-Zarate1, C. G. Isida Llerandi2,
J. Jimenez-Roman2, F. Gil Carrasco2, M. Ramirez1,
E. Hernandez-Quintela1. 1Cornea, Asociacion
Para Evitar la Ceguera, Mexico City, Mexico;
2
Glaucoma, Asociación Para Evitar la Ceguera en
México, Mexico City, Mexico
4343 — C0081 High CAE Responders Show
Greater Improvement in Signs and Symptoms of
Dry Eye after Treatment with MIM-D3. George
W. Ousler1, K. Meerovitch2. 1Ora, Inc., Andover,
MA; 2Mimetogen Pharmaceuticals, Montreal, QC,
Canada *CR, f
4344 — C0082 Dietary DHA Abrogate Intrinsic
Sex-Specific Differences in Lacrimal Gland Lipid
Mediator Circuits during Dry Eye. Kyle M. Hu, S.
B. Wang, E. Lu, P. J. Salveson, Y. Gao, K. Gronert.
Vision Science, University of California Berkeley,
Berkeley, CA
4345 — C0083 Analysis of Electrolyte
Composition of Precorneal Tear Film in Normal
Dogs and Horses and its Comparative Values in
Serum and Plasma. Gil Ben-Shlomo, L. N. Taylor.
Veterinary Clinical Sciences, College of Veterinary
Medicine, Iowa State University, Ames, IA
4329 — C0067 Clinical Comparison of Lipidbased and Aqueous Lubricant Eye drops. Peter
A. Simmons, C. Carlisle, G. Shi, J. G. Vehige.
Clinical Research, Allergan, Inc, Irvine, CA *CR, f
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
285
Wednesday Posters
8:30 am – 10:15 am
4326 — C0064 Secretory Group Two A
Phospholipase (sPLA2) Inhibition Decreases
Corneal Superficial Punctate Keratitis (SPK) in
Dry Eye Mice. Yi Wei, P. Li, J. Zou, S. P. Epstein,
N. Gadaria-Rathod, P. A. Asbell. Ophthalmology,
Mount Sinai School of Med, New York, NY *CR
4330 — C0068 Autologous Serum Eye Drop is
safe and Effective for Treatment of Dry Eyes in
Graft-versus-host Disease. Amir Azari, M. Rezaei
Kanavi, H. Potter, P. Hematti. Ophthalmology,
University of Wisconsin, Madison, WI
4346 – 4369 – Wednesday – Posters
4346 — C0084 Decreased Tear Production
in Dogs Following Phacoemulsification. R
D. Whitley1, H. E. Visser2, K. L. Tofflemire1, E.
M. Whitley3, R. A. Allbaugh1, G. Ben-Shlomo1.
1
Veterinary Clinical Sciences, Iowa State University,
Ames, IA; 2University of Georgia, Athens, GA;
3
Veterinary Pathology, Iowa State University, Ames,
IA
4347 — C0085 Impact of dry eye on reading
in a population based sample of the elderly:
the Salisbury Eye Evaluation. Suzanne W. van
Landingham, S. K. West, E. K. Akpek, B. E. Munoz,
P. Y. Ramulu. Wilmer Eye Institute, Johns Hopkins
University, Baltimore, MD *CR
4348 — C0086 Tear film osmolarity in rosacea
patients. Sabah Judith1, M. J. Mannis1, B. DurbinJohnson2, S. Azadmanesh Samimi3. 1Ophthalmology,
UC Davis Health System, Sacramento, CA;
2
Department of Public Health Sciences, UC
Davis, Davis, CA; 3UC Davis School of Medicine,
Sacramento, CA
4349 — C0087 The Severity of Dry Eye with
Computer Usage and Serum Lipid Levels. Laura
A. Norris, Z. B. Martindale, T. V. Mai-Tran, A. Z.
Chuang, R. W. Yee. Ophthalmology, The University
of Texas Health Science Center at Houston,
Houston, TX *CR
Wednesday Posters
8:30 am – 10:15 am
4350 — C0088 Royal jelly prevents lacrimal
hypofunction in Rat Visual Display Terminal
Users Model. Toshihiro Imada, S. Nakamura,
R. Hisamura, K. Tsubota. Ophthalmology, Keio
university, Shinjyukuku, Japan *CR
4351 — C0089 Development of a Chinese
version of the Ocular Comfort Index:
preliminary validation findings. Cecilia Chao1, B.
Golebiowski1, D. Y. Cui2, F. Stapleton1. 1School of
Optometry and Vision Science, The University of
New South Wales, Sydney, NSW, Australia; 2Brien
Holden Vision Institute, The University of New
South Wales, Sydney, NSW, Australia *CR
4352 — C0090 Clinical Research of Using
Oculus Keratograph for Observing the Location
of First Tear Film Break-up Point. Dan Wu,
J. Hong, J. Xu. EENT hospital of Fudan Uni.,
Shanghai, China
4353 — C0091 Allgrove Syndrome: complex
eye involvement and first evaluation by laser
scanning confocal microscopy. Angelica Dipinto1,
P. Fogagnolo2, D. Allegrini1, M. Digiuni1, L.
Migliavacca1, C. Pierrottet1, L. Ottobelli1, O.
Oneta1, L. M. Rossetti1. 1Eye Clinic, San Paolo
Hospital, Milan, Italy; 2G.B. Bietti Foundation
IRCCS, Rome, Italy
4354 — C0092 How Does Increasing Ocular
Surface Stimulation Affect Blinking? Ziwei Wu1,
C. G. Begley1, P. Situ1, A. J. Winkeler1, J. Zhang1,
T. L. Simpson2. 1Optometry, Indiana University,
Bloomington, IN; 2Optometry and Vision Science,
University of Waterloo, Waterloo, ON, Canada *CR
4355 — C0093 Do Tear Film Thinning Rates
Vary Locally? Adam J. Winkeler1, C. G. Begley1,
R. J. Braun2, R. Welch1. 1School of Optometry,
Indiana University, Bloomington, IN; 2Mathematics,
University of Delaware, Newark, DE *CR
4356 — C0094 Longitudinal Mixed Effect
OSDI Model in a Select Dry Eye Patient
Population after Acupuncture Treatment.
Vanessa Bowlin1, S. S. Samudre1, D. K. Dhaliwal2.
1
Clinical Research, Eastern Virginia Eye Institute,
Chesapeake, VA; 2School of Medicine, University
of Pittsburgh, Pittsburgh, VA *CR
4357 — C0095 The relationship of depression
and anxiety with dry eye subtypes. Louis
Tong1, 3, L. Hong4, R. Lee4, Y. Zhao4, S. C. Sung2,
P. P. Chiang4. 1Cornea and External Eye Disease
Service, Singapore National Eye Ctr, Singapore,
Singapore; 2Office of Clinical Science, Duke-NUS
graduate medical school, Singapore, Singapore;
3
Ophthalmology, Yong Loo Lin School of Medicine,
National University of Singapore, Singapore,
Singapore; 4Singapore Eye Research Institute,
Singapore, Singapore
4358 — C0096 The effect of tear lipid
biochemistry on tear evaporation rate during
contact lens wear. Athira Rohit1, 2, S. H. Brown3, 1,
M. D. Willcox2, 1, F. Stapleton1, 2. 1Optometry, Brien
Holden Vision Institute, Sydney, NSW, Australia;
2
Optometry, School of Optometry and Vision
Science, Sydney, NSW, Australia; 3School of Health
Sciences, University of Wollongong, Wollongong,
NSW, Australia *CR
4359 — C0097 Evaluation of a Modification of
the Brief Pain Inventory (BODI) as a Measure
of Severity of Dry Eye Disease. Maxwell Pistilli1,
E. Peskin1, H. S. Brader1, P. Dentone2, M. G.
Maguire1, P. A. Asbell2. 1Ophthalmology, University
of Pennsylvania, Philadelphia, PA; 2Ophthalmology,
Mount Sinai School of Medicine, New York, NY
*CR
4360 — C0098 Correlations between nonstimulated tear levels and conjunctival surface
expression of inflammation-related biomarkers
in normal and aqueous-deficient dry eye
patients. Roderick J. Fullard1, J. L. Bradley1, L.
D. Williams1, M. K. Tran1, N. M. Guyette1, T. P.
Than2, P. J. Shin1. 1Vision Sciences, University
of Alabama at Birmingham, Birmingham, AL;
2
Optometry, University of Alabama at Birmingham,
Birmingham, AL
4361 — C0099 Correlations of Signs and
Symptoms in Subjects with Dry Eye. Sunita
Saigal, P. Johnston, L. Smith. Ora, Inc., Andover,
MA *CR
4362 — C0100 Transcultural validation of
the 5-Item Dry Eye Questionnaire (DEQ-5)
for Mexican population. Everardo HernandezQuintela1, 2, N. Ramos-Betancourt1, 2, J. D.
Martinez1, 2, C. Santacruz Valdes4, 2, F. Beltran1, 2,
C. Ramírez-Assad1, 2, E. M. Mora Juarez1, 2,
A. Babayan3, 2. 1Cornea y Cirugia Refractiva,
Association Para Evitar la Ceguera, Mexico City,
Mexico; 2Colegio Nacional de Investigacion
en Ciencias Visuales, MARVO, Mexico City,
Mexico; 3Cornea y Cirugia Refractiva, Hospital
Fundacion Nuestra Señora de la Luz, Mexico City,
Mexico; 4Cornea y Cirugia Refractiva, Instituto de
Oftalmologia Conde de Valenciana, Mexico City,
Mexico
Exhibit Hall D0001-D0020
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
420 Neuro-Ophthalmology:
Papilledema, Characterization of Rare
Diseases, and Methods of Evaluation
Moderator: Raghu C. Mudumbai
4363 — D0001 Etiologies and visual outcomes
in secondary pediatric intracranial hypertension.
William Rhoades1, 2, G. Heidary2. 1Ophthalmology,
Boston University Medical Center, Boston, MA;
2
Ophthalmology, Children’s Hospital Boston,
Boston, MA
4364 — D0002 Changes of Choroidal
Thickness as Measured with Spectral Domain
OCT in Patients with Idiopathic Intracranial
Hypertension after Lowering of Intracranial
Pressure. Berthold Pemp, K. Kircher, A. Reitner,
U. Schmidt-Erfurth. Department of Ophthalmology,
Medical University of Vienna, Vienna, Austria *CR
4365 — D0003 Smoking associated with
cerebrospinal fluid shunt in patients with
idiopathic intracranial hypertension. Fran L.
Wu, M. S. Lee. Department of Ophthalmology and
Visual Neurosciences, University of Minnesota,
Saint Paul, MN
4366 — D0004 Correlation of Change in
Ocular Pulse Amplitude with Change in
Intracranial Pressure after Lumbar Puncture.
Keerthana Bolisetty1, C. J. Roberts2, 3, A. M.
Mahmoud2, 3, M. Okon3, S. E. Katz2, 3. 1College of
Medicine, The Ohio State University, Columbus,
OH; 2Ophthalmology, The Ohio State University,
Columbus, OH; 3Biomedical Engineering, The Ohio
State University, Columbus, OH *CR
4367 — D0005 Changes in Intracranial
Pressure (ICP) and Ocular Pulse Amplitude
(OPA) in Patients with Idiopathic Intracranial
Hypertension (IIH). Steven E. Katz1, 2, A. M.
Mahmoud1, 2, M. Okon2, K. Bolisetty3, R. H.
Small4, 2, C. J. Roberts1, 2. 1Ophthalmology, The
Ohio State University, Columbus, OH; 2Biomedical
Engineering, The Ohio State University, Columbus,
OH; 3College of Medicine, The Ohio State
University, Columbus, OH; 4Anesthesiology, The
Ohio State University, Columbus, OH *CR
4368 — D0006 Evaluation of Inner Retinal
Thicknesses in the Macula of Patients with
Chronic Papilledema from Pseudotumor Cerebri
Syndrome Using Frequency Domain OCT.
Clara L. Afonso1, A. S. Raza2, D. B. Fernandes1, D.
C. Hood2, M. L. Monteiro1. 1Ophthalmology, FM
USP, São Paulo, Brazil; 2Psychology, Columbia
University, New York, NY *CR
4369 — D0007 SD-OCT in monitoring
intracranial pressure in patients with CSF
shunts. Ali Torab Parhiz1, P. A. Sibony1, M. J.
Kupersmith2. 1Ophthalmology, SUNY at Stony
Brook, Stony Brook, NY; 2Ophthalmology, New
York Eye and Ear Infirmary, New York, NY
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
286
Wednesday – Posters – 4370 – 4389
4370 — D0008 Measurement of Retinal Nerve
Fiber Layer Thickness in Eyes with Optic Disc
Swelling by Using Scanning Laser Polarimetry
and Optical Coherence Tomography. Masayuki
Hata, K. Miyamoto, A. Oishi, N. Yoshimura. Kyoto
University Graduate School of Medicine, Kyoto,
Japan *CR
4371 — D0009 Correlation of Peripapillary
Retinal Nerve Fiber Layer Thickness and
Macular Thickness as Measured by Spectral
Domain Optical Coherence Tomography in
Patients with Severe Vision Loss in End Stage
Optic Neuropathy. Joseph P. Sheehan, C. E.
Francis, L. Ding, R. C. Mudumbai. Ophthalmology,
University of Washington, Seattle, WA
4372 — D0010 Teaching Ophthalmoscopy to
Medical Students: The TOTeMS Study. Philip S.
Garza1, L. P. Kelly1, B. B. Bruce2, E. B. Graubart1,
N. J. Newman3, V. Biousse2. 1Ophthalmology,
Emory University, Atlanta, GA; 2Ophthalmology
and Neurology, Emory University, Atlanta, GA;
3
Ophthalmology, Neurology, and Neurological
Surgery, Emory University, Atlanta, GA
4373 — D0011 Evaluation of localization test
under simulated very low vision conditions.
Takao Endo1, T. Fujikado2, H. Kanda2, T.
Morimoto2, S. Kitazawa3, K. Nishida1. 1Department
of Ophthalmology, Osaka University Graduate
School of Medicine, Osaka city, Japan; 2Department
of Applied Visual Science, Osaka University
Graduate School of Medicine, Osaka city, Japan;
3
Frontiers Biosciences, Osaka University Graduate
School of Medicine, Osaka city, Japan *CR
4374 — D0012 Pupil Size Dynamics During the
First Minutes of Dark Adaptation While Fixating
on a Target. Boris I. Gramatikov, K. Irsch, D. L.
Guyton. Ophthalmology, Johns Hopkins Wilmer
Eye Institute, Baltimore, MD *CR
4376 — D0014 A method of assessing global
motion perception in two-year old children
using the optokinetic reflex. Tzu-Ying Yu1, R. J.
Jacobs1, N. S. Anstice1, N. Paudel1, J. E. Harding2,
B. Thompson1. 1Optometry and Vision Science,
University of Auckland, Auckland, New Zealand;
2
Liggins Institute, University of Auckland,
Auckland, New Zealand *CR
4377 — D0015 Comparison of Diopsys Pattern
Reversal Visual Evoked Potential Responses and
Grating Acuity Measurements using the Teller
Acuity Card Procedure. Tina K. Green1, J. D.
Twelker1, 2, T. R. Kramer1, D. J. Mercer3, C. Ober4,
C. C. Donaldson1, H. Miller1, J. M. Miller1, 2, E.
M. Harvey1, 2. 1Ophthalmology and Vision Science,
University of Arizona, Tucson, AZ; 2College of
Public Health, University of Arizona, Tucson, AZ;
3
Watching Over Mothers & Babies Foundation,
Tucson, AZ; 4Save the Cord Foundation, Tucson,
AZ *CR
4379 — D0017 Sweep-VEP Acuity as a Clinical
Tool in the Diagnosis of Functional Visual Loss.
Paula Y. Sacai, A. Berezovsky, D. M. Rocha, S.
E. Watanabe, J. M. Pereira, N. N. Cavascan,
T. D. Soares, S. R. Salomao. Ophthalmology,
Universidade Federal de São Paulo, São Paulo,
Brazil
4380 — D0018 Visual field defects and retinal
nerve fibre layer thickness measurements
using optical coherence tomography in
migraine patients. Anna Midelfart1, 2, H.
Bjurstrøm5, S. Sollie5, E. Midelfart3, S. Midelfart4.
1
Ophthalmology, Norwegian Univ of Sci & Tech,
Trondheim, Norway; 2Ophthalmology, University
Hospital, Trondheim, Norway; 3Neurology,
Spesialhelsetjenesten, Trondheim, Norway; 4Public
Health and General Practice, Norwegian University
of Sci and Tech, Trondheim, Norway; 5Faculty of
Medicine, Norwegian University of Sci and Tech,
Trondheim, Norway
4381 — D0019 Distinctive Clinical Signs
Differentiating Oculopharyngeal Muscular
Dystrophy from Myasthenia Gravis. Jeffrey
Peterson, M. T. Yen, R. Foroozan. Department
of Ophthalmology, Cullen Eye Institute, Baylor
College of Medicine, Houston, TX *CR
4382 — D0020 Ocular Manifestations
and Optic Nerve Changes in Patients with
Amyotrophic Lateral Sclerosis (ALS). Joseph
Simonett, J. Chou, N. Siddique, J. L. Armstrong, A.
A. Fawzi, T. Siddique, N. J. Volpe. Northwestern
University, Chicago, IL *CR
Exhibit Hall D0021-D0066
Wednesday, May 08, 2013 8:30 AM-10:15 AM
4384 — D0022 Geographic Variability In The
Age Of First Cataract Surgery And Rate Of
Cataract Surgery Among Persons Living In
Communities Throughout The U.S. Courtney Y.
Kauh, T. S. Blachley, P. R. Lichter, P. P. Lee, J. D.
Stein. Ophthalmology and Visual Sciences, The
University of Michigan, Ann Arbor, MI *CR
4385 — D0023 Power & type II errors in
recently published ophthalmology research.
Zainab Khan, C. Milko, A. K. Kurji, M. Iqbal, D.
Almeida. Ophthalmology, Queen’s University,
Kingston, ON, Canada
4386 — D0024 A Longitudinal Analysis of
1,660 Recipients of Bilateral Laser Peripheral
Iridotomies to Determine Subsequent Need for
Cataract Surgery and Additional Interventions
for Glaucoma. Sharmini Balakrishnan, T.
S. Blachley, J. Weizer, P. P. Lee, J. D. Stein.
Ophthalmology, University of Michigan Kellogg
Eye Center, Ann Arbor, MI *CR
4387 — D0025 Are Chronic Users of
Chloroquine or Hydroxychloroquine Undergoing
Regular Visits to Eye Providers and Diagnostic
Testing to Check for Maculopathy? Melisa
Nika1, T. S. Blachley1, P. A. Edwards2, P. P.
Lee1, J. D. Stein1. 1Ophthalmology and Visual
sciences, Kellogg Eye Center, Ann Arbor, MI;
2
Ophthalmology and Visual sciences, Henry Ford,
Detroit, MI *CR
4388 — D0026 Optimizing cost-effectiveness
analyses of treatments for neovascular agerelated macular degeneration using real-life
data. Robert P. Finger1, 2, A. Hsueh1, J. E. Keeffe1,
R. H. Guymer1. 1Ophthalmology, Centre for Eye
Research Australia, Melbourne, VIC, Australia;
2
Ophthalmology, University of Bonn, Bonn,
Germany *CR
4389 — D0027 Comparison of Resource
Consumption in Penetrating versus Endothelial
Keratoplasty from 2009-2010. Duna RaoofDaneshvar, R. M. Shtein, T. S. Blachley, M. A.
Woodward, S. I. Mian, A. Sugar, J. D. Stein.
Ophthalmology, University of Michigan, Ann
Arbor, MI *CR
Clinical/Epidemiologic Research
421 Eye Care
Moderators: Joshua D. Stein and
Graham E. Trope
4383 — D0021 Screening of Potentially
Blinding Eye Diseases by Vision Technicians at
Rural Vision Centres in Southern India and their
Referral Agreement with an Ophthalmologist.
Uday Addepalli1, S. Vasantha2, R. C. Khanna3, K.
Sannapaneni3, V. Kovai3. 1VST Center for Glaucoma
Services, L V Prasad Eye Insititute, Hyderabad,
India; 2Glaucoma, Sarojini Devi Eye Hospital,
Hyderabad, India; 3Allen Foster Research Centre
for Community Eye Health, International Centre for
Advancement of Rural Eye care, L V Prasad Eye
Insititute, Hyderabad, India
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
287
Wednesday Posters
8:30 am – 10:15 am
4375 — D0013 Effects of Age on the Peripheral
60-4 Test Comparing Stimulus Sizes III, V, and
VI. Jordan Haas1, 2, C. K. Doyle1, 2, C. A. Johnson2,
M. Wall1, 2. 1Ophthalmology, Iowa City VA
Healthcare System, Iowa City, IA; 2Ophthalmology
and Visual Sciences, University of Iowa, Carver
College of Medicine, Iowa City, IA *CR
4378 — D0016 Prospective study on the
contribution of MRI in the analysis of isolated
mydriasis: a new kind of neurovascular conflict.
Fanny Tréchot1, M. Braun2, V. Cloche1, K. Angioi1.
1
Department of Ophthalmology, Chu Nancy
Hopitaux De Brabois, Vandoeuvre-les-Nancy,
France; 2Department of Neuroradiology, Chu Nancy
Hopital CentraL, Nancy, France
4390 – 4412 – Wednesday – Posters
4390 — D0028 The Sight Loss and Vision
Priority Setting Partnership (SLV-PSP) - initial
survey methods, respondents’ demographics
and preliminary categorisation framework.
Michael Bowen1, 2, M. Acton5, D. M. Conroy5, R.
P. Wormald10, 3, A. Lightstone8, 9, K. Cowan7, C.
Bunce10, 4, M. Fenton6, K. Bonstein10. 1Research,
College of Optometrists, London, United Kingdom;
2
Psychology, City University London, London,
United Kingdom; 3Cochrane Eyes and Vision
Group, London School of Hygiene and Tropical
Medicine, London, United Kingdom; 4Institute
of Ophthalmology, University College London,
London, United Kingdom; 5Fight for Sight, London,
United Kingdom; 6UK Database of Uncertainties
about the Effects of Treatments (UK DUETs),
National Institute for Clinical Excellence (NICE),
London, United Kingdom; 7The James Lind
Alliance, National Institute for Health Research
(NIHR), London, United Kingdom; 8VISION 2020
UK, London, United Kingdom; 9Royal National
Institute for Blind People (RNIB), London, United
Kingdom; 10Biomedical Research Institute at
Moorfields Eye Hospital NHS Foundation Trust and
UCL Institute of Ophthalmology, National Institute
for Health Research, London, United Kingdom *CR
Wednesday Posters
8:30 am – 10:15 am
4391 — D0029 Applying Lean Principles
to Clinical and Translational Research in
Ophthalmology. Vesper Williams1, P. Summerfelt1,
T. Kaczanowski1, K. Packard1, D. M. Bishop1, M.
Goldberg1, A. Dubra1, 2, J. Carroll1, 3, A. Suneja4.
1
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 2Biophysics, Medical College
of Wisconsin, Milwaukee, WI; 3Cell Biology,
Neurobiology, and Anatomy, Medical College
of Wisconsin, Milwaukee, WI; 4FlowOne Lean
Consulting, LLC, Milwaukee, WI *CR
4392 — D0030 Evaluation of Fundamental
Ophthalmology Knowledge among Internal
Medicine and Emergency Department Residents.
Priya Janardhana, M. A. Desai. Boston Medical
Center, Chestnut Hill, MA
4393 — D0031 The Ophthalmology Job
Market In the Aftermath of the Great Recession.
Chukwuemeka C. Nwanze1, R. A. Adelman3, 1,
J. Barth2, 1. 1Lab of Computer Science, MGH,
Lab of Computer Science, Chestnut Hill, MA;
2
Ophthalmology Job Center, American Academy of
Ophthalmology, SanFrancisco, CA; 3Department of
Ophthalmology and Visual Sciences, Yale School of
Medicine, New Haven, CT
4394 — D0032 PROSE treatment for moderate
to severe ocular graft-versus-host disease:
Analysis of utilization rates versus projected
demand across four centers. Ryan Ridges, B.
Beard, D. S. Jacobs. Boston Foundation for Sight,
Needham, MA *CR
4395 — D0033 Ophthalmology Consultation on
Asymptomatic Patients. Ryan K. Wong, J. Huang.
Ophthalmology and Visual Science, Yale University
School of Medicine, New Haven, CT
4396 — D0034 The economic impact of
cataract surgery in a remote Ghanaian village
three years after surgical intervention. John
D. Welling1, E. R. Newick2, G. C. Tabin2, 3.
1
Ophthalmology, The Ohio State University
Havener Eye Institute, Columbus, OH; 2Himalayan
Cataract Project, Waterbury, VT; 3Ophthalmology
and Visual Sciences, University of Utah John A.
Moran Eye Center, Salt Lake City, UT
4397 — D0035 Immediately Sequential
Bilateral Cataract Surgery-A Cost-effective
Procedure. Monali Malvankar1, W. G. Hodge1, R.
Filek1, M. Iqbal2, M. A. Shakir1, M. Malvankar1, S.
Chavda1, F. F. Si1. 1Ophthalmology, The University
of Western Ontario, London, ON, Canada; 2Queens
University, Kingston, ON, Canada
4398 — D0036 iPhone applications in
ophthalmology: Current capabilities, limitations
and future directions. Nicholas M. Cheng1, R.
Chakrabarti2, 3, J. K. Kam3. 1The Royal Melbourne
Hospital, Melbourne, VIC, Australia; 2Centre for
Eye Research Australia, Melbourne, VIC, Australia;
3
The Royal Victorian Eye and Ear Hospital,
Melbourne, VIC, Australia
4399 — D0037 Activity and epidemiology of a
recently opened ophthalmic emergency center
in a University Hospital. Francois Ameloot1, 3,
N. Agrinier2, F. Tréchot1, T. Maalouf1, K. Angioi1.
1
Ophthalmology, University Hospital of Nancy,
Nancy, France; 2Epidémiologie et Evaluation
Cliniques, University Hospital of Nancy, Nancy,
France; 3Ophthalmology, CHR Metz, Metz, France
4400 — D0038 Stability of the Relationship
Between Self-Reported Vision Impairment and
Blindness and Medical Care Expenditures Over
Time. Kevin D. Frick, E. Wehler. Health Policy and
Management, Johns Hopkins Bloomberg Sch of
Public Hlth, Baltimore, MD *CR
4401 — D0039 Glaucoma Treatment: A Closer
Look at Non-adherence. Sumir Pandit1, T. C.
Chen2. 1Harvard Medical School, Boston, MA;
2
Ophthalmology/Glaucoma Service, Mass Eye and
Ear Infirmary, Boston, MA
4402 — D0040 Predictive Factors for
Incomplete Adherence to Glaucoma
Management amongst Singaporean Chinese.
Reuben C. Foo1, H. Chan2, E. L. Lamoureux3, 4, R.
Wong2, S. Ho4, G. Rees3, T. Aung1, 4, S. Perera1, 4,
T. Wong1, 4. 1Singapore National Eye Centre,
Singapore, Singapore; 2Yong Loo Lin School of
Medicine, Singapore, Singapore; 3Centre for Eye
Research Australia, University of Melbourne,
Royal Victorian Eye and Ear Hospital, Melbourne,
VIC, Australia; 4Singapore Eye Research Institute,
Singapore, Singapore *CR
4403 — D0041 Patient Adherence and
Persistence with Topical Ocular Hypotensive
Therapy: a Claims-Based Comparison of
Bimatoprost 0.01% and Travoprost with sofZia.
Joanna Campbell1, G. F. Schwartz2, 3, B. LaBounty4,
J. W. Kowalski1, V. D. Patel1. 1GHOSR, Allergan,
Irvine, CA; 2Greater Baltimore Medical Center,
Baltimore, MD; 3Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD; 4Principled
Strategies, Inc., Encinitas, CA *CR
4404 — D0042 Identifying requirements for
effective glaucoma electronic health records: a
consensus study. John E. Somner1, R. R. Bourne1,
P. Shah2, R. Froud3. 1Anglia Ruskin University,
Vision & Eye Research Unit, Cambridge, United
Kingdom; 2National Institute for Health Research
(NIHR) Biomedical Research Centre (BRC),
Moorfields Eye Hospital NHS Foundation Trust,
London, United Kingdom; 3Centre for Primary Care
and Public Health, Barts and The London School of
Medicine and Dentistry, London, United Kingdom
*CR
4405 — D0043 Quality of Referral Letters
to a Tertiary Glaucoma Unit and adherence to
Glaucoma Guidelines. Jason Cheng, L. BeltranAgullo, G. E. Trope, Y. M. Buys. Ophthalmology &
Vision Sciences, Toronto Western Hospital, Toronto,
ON, Canada *CR
4406 — D0044 The Utility of a Medical Student
Run Glaucoma Screening Program. Mona A.
Kaleem, V. C. Lerebours, J. W. Logan, J. Llano, L.
S. Jones. Department of Ophthalmology, Howard
University Hospital, Washington, DC
4407 — D0045 Opportunistic Glaucoma
Screening in Rural India: Role of Vision Centers.
Mona Khurana, M. A. KADER, R. Ramakrishnan.
Glaucoma, Aravind Eye Hospital, Tirunelveli, India
4408 — D0046 Qualitative Analysis of WebBased LASIK Information Sessions. Roni
M. Shtein, P. P. Lee. Ophthalmology, Univ of
Michigan-Kellogg Eye Ctr, Ann Arbor, MI *CR
4409 — D0047 Results of the Appalachian
Vision Outreach Program: Year 2. J V. Odom, R.
Coakley, J. Charlton, S. Morrison. Ophthalmology,
West Virginia Univ Eye Inst, Morgantown, WV
4410 — D0048 Are outcomes in primary
retinal detachment repair related to distance
away from an academic medical center? Kristen
Harris Nwanyanwu, L. M. Niziol, D. C. Musch, D.
N. Zacks. Department of Ophthalmology and Visual
Sciences, University of Michigan, Ann Arbor, MI
*CR
4411 — D0049 Consent For Future Corneal
Transplantation And Eye Research From AMD
Patients In An Ophthalmic Clinic. Meidong
Zhu1, 2, J. Chew1, 3, P. Georges2, C. Petsoglou1, 2, A.
A. Chang1, 3. 1SSI, Ophthalmology & Eye Health,
Sydney Eye Hospital Campus, University of
Sydney, Sydney, NSW, Australia; 2Lions New South
Wales Eye Bank, NSW Organ and Tissue Donation
Service, Sydney, NSW, Australia; 3Sydney Retina
Clinic & Day Surgery, Sydney, NSW, Australia *CR
4412 — D0050 Objective and subjective
severity of affections observed at emergency
room in ophthalmology. Aurelie Pison1, C.
Mehanna1, 4, G. Sawiress2, R. Mikou1, A. Queant3, 1,
A. P. Brezin3, 1, J. Bourges3, 1. 1Department of
Ophthalmology, Hotel Dieu/Cochin Hospital,
APHP, Paris, Paris, France; 2Department of
informatics, Hotel Dieu/Cochin Hospital, APHP,
Paris, Paris, France; 3Paris Descartes School of
Medicine, Sorbonne Paris Cité University, Paris,
France; 4Team 17, INSERM, CIC des Cordeliers,
Paris, France *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
288
Wednesday – Posters – 4413 – 4430
4413 — D0051 Acceptance, Attitudes and
Beliefs Of Singaporean Chinese Towards
Subconjunctival, Intracameral and Punctal Plug
Methods of Sustained Glaucoma Drug Delivery
Systems. Hiok Hong Chan1, 2, T. Wong1, 3, E. L.
Lamoureux3, 4, S. Perera1. 1Glaucoma, Singapore
National Eye Centre, Singapore, Singapore; 2Yong
Loo Lin School of Medicine, National of University
of Singapore, Singapore, Singapore; 3Singapore Eye
Research Institute, Singapore, Singapore; 4Centre
for Eye Research Australia, Melbourne, VIC,
Australia *CR
4419 — D0057 Comparing Patient and Public
Preferences for Health States Associated with
Age-Related Macular Degeneration. Thomas
Butt1, H. M. Dunbar1, S. Morris2, S. Orr3, G. S.
Rubin1, 4. 1Institute of Ophthalmology, University
College London, London, United Kingdom;
2
Department of Applied Health Research,
University College London, London, United
Kingdom; 3Department of Civil and Environmental
Engineering, University College London, London,
United Kingdom; 4NIHR Moorfields Biomedical
Research Centre, London, United Kingdom
4414 — D0052 Electronic Health Record
Systems in Ophthalmology: Impact on Operating
Room Time Requirements for Cataract Surgery.
Daniel C. Tu1, 2, D. S. Sanders2, S. Read-Brown2, A.
S. Brown2, D. Choi3, T. R. Yackel4, 5, M. F. Chiang2, 4.
1
Ophthalmology, Portland Veterans Administration
Medical Center, Portland, OR; 2Casey Eye Institute,
Ophthalmology, Oregon Health & Science
University, Portland, OR; 3Public Health and
Preventive Medicine, Oregon Health & Science
University, Portland, OR; 4Medical Informatics,
Oregon Health & Science University, Portland, OR;
5
Clinical Epidemiology, Oregon Health & Science
University, Portland, OR *CR
4420 — D0058 Provision of Mass Drug
Administration for Trachoma Control: Cost per
gain in coverage. Sheila K. West1, H. A. Mkocha2,
B. E. Munoz1, K. D. Frick3. 1Ophthalmology, Johns
Hopkins Wilmer Eye Inst, Baltimore, MD; 2Kongwa
Trachoma Project, Kongwa, United Republic of
Tanzania; 3Health Services Research Division,
Johns Hopkins University, Baltimore, MD *CR
4415 — D0053 Efficiency improvements using
an ophthalmological Picture Archiving and
Communication System (PACS) in the diagnostic
workflow of an eye hospital. Karsten U. Kortuem,
W. J. Mayer, S. F. Leicht, L. Reznicek, A. Kampik,
M. Kernt. Ophthalmology, Ludwig-MaximiliansUniversity, Munich, Germany *CR
4417 — D0055 Comparison of theoretical
demand for glaucoma eye care by the AfricanAmerican population of cook county to the
supply of ophthalmologic manpower as a pilot
study of access to care. Stephen Watson, D.
Pyatetsky. Ophthalmology, Northwestern University
Feinberg School of Medicine, Chicago, IL
4418 — D0056 Trends in Utilization of
Ancillary Testing for Patients with Exudative
Macular Degeneration and Macular Edema
from 2001 to 2009. Eric W. Schneider1, 2, P.
Mruthyunjaya1, N. Talwar2, K. Harris Nwanyanwu2,
B. Nan3, J. D. Stein2. 1Ophthalmology, Duke
University, Durham, NC; 2Ophthalmology and
Visual Sciences, University of Michigan, Ann
Arbor, MI; 3Biostatistics, University of Michigan,
Ann Arbor, MI *CR
4422 — D0060 Compliance with Eye Screening
Guidelines among Newly-Diagnosed Diabetic
Patients without Diabetic Retinopathy. David
J. Lee1, P. Rosa2, W. J. Feuer2, B. L. Lam2, J. C.
Schiffman2, N. Kumar1, A. Morante2. 1Epidemiology
& Public Health, University of Miami, Miami, FL;
2
Bascom Palmer Eye Institute, University of Miami,
Miami, FL *CR
4423 — D0061 Methods of Assessing Provider
Performance for Quality Improvement. Paul
P. Lee1, G. McGwin2, S. Asrani1, W. Rafferty1,
D. Lobach1, K. Kimrey1. 1Ophthalmology and
Visual Sciences, University of Michigan, Ann
Arbor, MI; 2University of Alabama - Birmingham,
Birmingham, AL *CR, f
4424 — D0062 Electronic health record
(EHR) systems in ophthalmology: Impact on
clinical documentation. David S. Sanders1, D.
Lattin1, D. C. Tu1, 2, S. Read-Brown1, D. J. Wilson1,
T. S. Hwang1, J. C. Morrison1, T. R. Yackel3, M.
F. Chiang1, 3. 1Ophthalmology, Oregon Health &
Science University, Portland, OR; 2Ophthalmology
Operative Care Division, Portland VA Medical
Center, Portland, OR; 3Medical Informatics and
Clinical Epidemiology, Oregon Health & Science
University, Portland, OR *CR
4426 — D0064 Implementation of electronic
health record systems in ophthalmology:
impact on clinical volume compared to other
medical fields. Travis Redd1, S. Read-Brown1, A.
Kitzmiller1, T. R. Yackel2, D. Choi3, M. F. Chiang2.
1
Ophthalmology, Casey Eye Institute, Oregon
Health & Science University, Portland, OR;
2
Ophthalmology & Medical Informatics, Casey
Eye Institute, Oregon Health & Science University,
Portland, OR; 3Public Health & Preventive
Medicine, Oregon Health & Science University,
Portland, OR *CR
4427 — D0065 Physician and patient
perceptions of electronic health record (EHR)
use in a tertiary care ophthalmologic clinic.
Patrick Chan, R. Singh, S. Charvat. Cole Eye
Institute, Cleveland Clinic, Cleveland, OH *CR
4428 — D0066 Critical Review of High
Quality Ophthalmology Educational Web
Resources Targeting Trainees. Milad Modabber1,
S. Arora2, K. F. Damji3, F. Adatia4. 1Medicine,
McMaster University, Hamilton, ON, Canada;
2
Ophthalmology, University of Alberta, Edmonton,
AB, Canada; 3Ophthalmology, University of
Alberta, Edmonton, AB, Canada; 4Ophthalmology,
University of Calgary, Edmonton, AB, Canada
Exhibit Hall D0114-D0126
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
422 Ocular Trauma
Moderator: Gerald McGwin
4429 — D0114 Characteristics of eyelid
laceration due to dog bite in children. Mohammad
Ali Sadiq1, 2, I. Mantagos1, 2. 1Department of
Ophthalmology, Boston Children’s Hospital,
Boston, MA; 2Ophthalmology, Harvard Medical
School, Boston, MA
4430 — D0115 Demographic and Clinical
Profile of Ocular Chemical Injuries in Children.
Pooja Bandivadekar, H. Shekhar, N. Sharma, R. B.
Vajpayee. Dr.rajendra prasad Centre, AIIMS, New
Delhi, India
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
289
Wednesday Posters
8:30 am – 10:15 am
4416 — D0054 Ambulatory Surgery Center
(ASC) Utilization by three Ophthalmic Subspecialists: 1999-2011. Kamyar Vaziri1, A.
A. Moshfeghi1, T. Hernandez-Boussard2, N.
Fijalkowski3, D. M. Moshfeghi3. 1Ophthalmology,
Bascom Palmer Eye Institute, University of Miami
Miller School of Medicine, Miami, FL; 2Surgery,
Stanford University School of Medicine, Palo Alto,
CA; 3Ophthalmology, Byers Eye Institute, Horngren
Family Vitreoretinal Center, Stanford University
School of Medicine, Palo Alto, CA *CR
4421 — D0059 Trachoma Control: A Potential
Field Test for Ocular C. Trachomatis Infection.
Alexander Jenson1, 2, L. Dize3, H. A. Mkocha2, 1, B.
E. Munoz1, 2, J. S. Lee1, 2, S. K. West1, 2. 1Dana Center
for Preventative Opthamology, The Johns Hopkins
University, Baltimore, MD; 2Kongwa Trachoma
Project, The Johns Hopkins University, Kongwa,
United Republic of Tanzania; 3Infectious Disease,
The Johns Hopkins University, Baltimore, MD
4425 — D0063 Ophthalmologists’ Attitudes
on Implementing an Electronic Health Record
System. Monica M. Michelotti1, J. Weizer1, T. S.
Blachley1, K. Zheng2, M. Couper3, G. Greenberg4,
S. Kileny5, G. Branford6, D. A. Hanauer5.
1
Ophthalmology, University of Michigan, Ann
Arbor, MI; 2School of Public Health, University
of Michigan, Ann Arbor, MI; 3Institute for Social
Research, University of Michigan, Ann Arbor, MI;
4
Family Medicine, University of Michigan, Ann
Arbor, MI; 5Pediatrics, University of Michigan,
Ann Arbor, MI; 6Internal Medicine, University of
Michigan, Ann Arbor, MI
4431 – 4452 – Wednesday – Posters
4431 — D0116 Motor Vehicle CrashAssociated Eye Injuries Presenting to United
States Emergency Departments. Grayson W.
Armstrong1, 2, A. J. Chen1, 3, J. G. Linakis4, 5,
M. J. Mello2, 5, P. B. Greenberg1, 6. 1Division of
Ophthalmology, Warren Alpert Med Sch of Brown
Univ, Providence, RI; 2Department of Community
Health, Warren Alpert Medical School of Brown
University, Providence, RI; 3Program in Liberal
Medical Education, Brown University, Providence,
RI; 4Department of Pediatrics, Warren Alpert
Medical School of Brown University, Providence,
RI; 5Department of Emergency Medicine, Warren
Alpert Medical School of Brown University,
Providence, RI; 6Section of Ophthalmology,
Providence VA Medical Center, Providence, RI
4440 — D0125 Utilizing HIWA, a Scoring
System of Pediatric Ocular Trauma
Retrospective Reports, Analyzing Existing
Literature and Informing Future Standards.
Andrea Honda1, P. Latkany1, M. Lorenzo1, E. Su2.
1
New York Eye and Ear Infirmary, New York, NY;
2
St. Luke’s Roosevelt Hospital, New York, NY
4432 — D0117 A Ten Year Review of Open
Globe Trauma in Elderly Patients at an Urban
Hospital. Iris Y. Sheng, A. M. Bauza, P. D. Langer,
M. A. Zarbin, N. Bhagat. IOVS, New Jersey
Medical School, Newark, NJ *CR
Wednesday, May 08, 2013 8:30 AM-10:15 AM
4433 — D0118 Clinical outcomes of surgicallytreated trapdoor fractures in the pediatric
population. Kathleen C. Oktavec, S. L. Merbs, M.
Grant. Division of Oculoplastics, The Wilmer Eye
Institute, Baltimore, MD *CR
Wednesday Posters
8:30 am – 10:15 am
4434 — D0119 Severe Ocular Trauma In The
Emergency Room. Albert Lin, C. Confait, S. T.
Hoadley, M. Ahmad, C. J. Chen. Ophthalmology,
Univ of Mississippi Med Center, Jackson, MS
4435 — D0120 Outcomes and characteristics
of open-globe injuries with delayed presentation.
Danielle Trief1, 2, M. T. Andreoli3, A. S. Shah1, 2, Y.
Yonekawa1, 2, C. M. Andreoli1, 4. 1Ophthalmology,
Mass Eye and Ear Infirmary, Boston, MA;
2
Ophthalmology, Boston Children’s Hospital,
Boston, MA; 3Ophthalmology, University of
Illinois College of Medicine at Chicago, Chicago,
IL; 4Ophthalmology, Harvard Vanguard Medical
Associates, Boston, MA
4436 — D0121 Correlation of Ocular Trauma
Score and visual acuity outcomes in combatrelated traumatic cataracts. Michael P. Smith, M.
Colyer, D. L. Greenburg. Ophthalmology, Walter
Reed Nt’l Military Med Ctr, Bethesda, MD
4437 — D0122 Ocular and adnexal injuries in
patients with all-terrain vehicle accidents in West
Virginia. Evan Newbolt, C. B. Chen, J. Nguyen, J.
Sivak-Callcott, B. D. Ellis, C. M. Bingham. West
Virginia University, Morgantown, WV
4438 — D0123 Characteristics and
Management of Traumatic Eyes with Full
Thickness Corneal Lacerations. Yi C. Lai, A.
M. Bauza, P. D. Langer, S. Guo, D. S. Chu, A. S.
Khouri, R. D. Fechtner, R. E. Turbin, N. Bhagat.
Institute of Ophthalmology and Visual Science,
New Jersey Medical School, Newark, NJ *CR
4439 — D0124 Nail Gun-Induced Open Globe
Injuries: A Ten-Year Retrospective Review.
Avni Shah, A. M. Bauza, A. M. Kolomeyer, P.
D. Langer, M. A. Zarbin, N. Bhagat. Institute of
Ophthalmology and Visual Science, UMDNJ New
Jersey Medical School, Newark, NJ *CR
4441 — D0126 Enucleation following Open
Globe Injury. Ananya Anne, A. M. Bauza, P. D.
Langer, R. E. Turbin, M. A. Zarbin, N. Bhagat.
University of Medicine and Dentistry of New
Jersey, Newark, NJ *CR
Exhibit Hall D0182-D0236
Glaucoma
423 Ocular Blood Flow; Surgery and
Wound Healing
Moderators: Leopold Schmetterer and Alon Harris
4442 — D0182 Retinal Nerve Fiber Layer
Thickness is Correlated to Retrobulbar Blood
Flow in Glaucoma Patients of African Descent.
Anne Schroeder1, A. Harris1, B. A. Siesky1, L.
A. Tobe1, N. J. Kim1, A. Amireskandari1, B. M.
Marek1, L. Racette1, G. J. Eckert2, A. Tyring1.
1
Ophthalmology, Indiana University School
of Medicine, Indianapolis, IN; 2Division of
Biostatistics, Indiana University School of
Medicine, Indianapolis, IN *CR
4443 — D0183 Changes in Retinal Blood Flow
are Strongly Correlated to Changes in Optic
Nerve Head Morphology in Patients of African
Descent. Leslie A. Tobe1, A. Harris1, B. A. Siesky1,
L. Racette1, D. WuDunn1, A. Amireskandari1,
N. J. Kim1, A. H. Huck1, A. Tyring1, M. Zalish2.
1
Ophthalmology, Indiana University School of
Medicine, Indianapolis, IN; 2Ophthalmology,
Kaplan Medical Center, Rehovot, Israel *CR
4444 — D0184 Comparison of Nebulized
dorzolamide/timolol fixed combination
Mist vs Drops on Retrobulbar Blood Flow,
Intraocular Pressure in Glaucoma Patients.
Ruta Barsauskaite1, A. Harris2, I. Januleviciene1,
L. Siaudvytyte1, V. Diliene1, B. Siesky2. 1Eye
Clinic, Lithuanian University of Health Sciences,
Kaunas, Lithuania; 2Eugene and Marilyn Glick Eye
Institute, Indiana University School of Medicine,
Indianapolis, IN *CR, f
4445 — D0185 Ocular Hemodynamic Changes
after Trabeculectomy in Pseudoexfoliative and
Primary Open-Angle Glaucoma. Vaida Diliene1,
A. Harris2, I. Januleviciene1, L. Siaudvytyte1, R.
Barsauskaite1, B. Siesky2. 1Eye Clinic, Lithuanian
University of Health ASciences, Kaunas, Lithuania;
2
Eugene and Marilyn Glick Eye Institute, Indiana
University School of Medicine, Indianapolis, IN
*CR, f
4446 — D0186 Systemic Blood Pressure and
Ocular Perfusion Pressure Affect Macular
Thickness in Glaucoma Patients of African
Descent. Brian M. Marek1, A. Harris1, B. A. Siesky1,
L. A. Tobe1, A. Tyring1, A. Amireskandari1, N. J.
Kim1, J. G. Paschall1, G. J. Eckert2, L. Racette1.
1
Ophthalmology, Indiana Univ. Sch. of Medicine,
Indianapolis, IN; 2Division of Biostatistics, Indiana
Univ. Sch. of Medicine, Indianapolis, IN *CR
4447 — D0187 Retinal and Macular
Morphology is Correlated with Retrobulbar
Vascular Resistance in Diabetic Patients with
Glaucoma. Austin L. Gerber1, A. Harris1, B. A.
Siesky1, G. J. Eckert3, I. Januleviciene2, N. J. Kim1,
A. Amireskandari1, B. M. Marek1, L. A. Tobe1, A.
H. Huck1. 1Ophthalmology, Indiana Univ School
of Med, Indianapolis, IN; 2Eye Clinic, Lithuanian
University of Health Sciences, Kaunas, Lithuania;
3
Division of Biostatistics, Indiana Univ School of
Med, Indianapolis, IN *CR
4448 — D0188 Blood pressure induced
dynamic blood flow autoregulation in the optic
nerve head of early experimental glaucoma. Lin
Wang, C. Piper, G. Cull, C. F. Burgoyne. Devers
Eye Institute, Legacy Research Institute, Portland,
OR *CR
4449 — D0189 The NO donor, isorbide-5mononitrate alone or combined with timolol,
latanoprost or dorzolamide ameliorates
intraocular pressure and ocular hemodynamic in
an experimental model of glaucoma in rabbits.
Francesco Impagnatiello1, B. Giambene2, F.
Fabrizi3, E. Bastia1, F. Galassi2, E. Masini3. 1Nicox
Research Institute, Bresso, Milan, Italy; 2Eye Clinic,
University of Florence, Florence, Italy; 3Preclinical
and Clinical Pharmacology, University of Florence,
Florence, Italy *CR
4450 — D0190 Effects of diverse Nitric
Oxide donation on ocular hemodynamic and
intraocular pressure in normotensive rabbits.
Elena Bastia1, F. Impagnatiello1, D. Miglietta1,
B. Giambene2, E. Masini3, N. Almirante1. 1Nicox
Research Institute, Bresso, Milan, Italy; 2Eye Clinic,
University of Florence, Florence, Italy; 3Preclinical
and Clinical Pharmacology, University of Florence,
Florence, Italy *CR
4451 — D0191 Association between waveform
changes in optic nerve head circulation and
retinal nerve fiber layer thickness in normaltension glaucoma patients compared to healthy
subjects, measured by laser speckle flowgraphy.
Yukihiro Shiga, Y. Yokoyama, T. Asano, S. Maekawa,
S. Tsuda, N. Aizawa, K. Omodaka, M. Ryu, T.
Nakazawa. Ophthalmology, Tohoku University,
Sendai, Japan *CR
4452 — D0192 Analysis of the Correlation
Between Peripapillary Choroidal Thickness
and the Nerve Fiber Layer Damage in Primary
Open Angle Glaucoma Patients. Nimesh Patel1, C.
Krishnan2, 1. 1Tufts University School of Medicine,
Boston, MA; 2New England Eye Care Center,
Boston, MA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
290
Wednesday – Posters – 4453 – 4474
4453 — D0193 Change in intraocular pressure
is a major determinant of retinal vein pulsation
properties. William Morgan1, M. Hazelton2, B.
Betz-Stablein2, P. House1, Y. Dao-Yi1. 1Lions Eye
Institute, Nedlands, WA, Australia; 2Institute
of Fundamental Sciences, Massey University,
Palmerston North, New Zealand *CR, f
4454 — D0194 Nonphysiologic nocturnal
blood pressure dipping in Primary Open Angle
Glaucoma (POAG) and Normal Pressure
Glaucoma (NPG) patients. Karin R. Pillunat, C.
Hermann, O. Furashova, E. Spoerl, L. E. Pillunat.
Dept of Ophthalmology, Univ Clinic Carl Gustav
Carus Dresden, Dresden, Germany f
4455 — D0195 Relation of Spontaneous Retinal
Venous Pulsation and Disc Hemorrhage in
Open Angle Glaucoma. Mijin Kim1, 2, T. Kim1, 2,
R. N. Weinreb3, E. Lee1, 2, J. Seo4, K. Park1, D.
Kim1. 1Ophthalmology, Seoul National University
Bundang Hospital, Seongnam, Gyeonggi-do,
Republic of Korea; 2Ophthalmology, Seoul National
University College of Medicine, Seoul, Republic of
Korea; 3Hamilton Glaucoma Center and Department
of Ophthalmology, University of California San
Diego, La Jolla, CA; 4Pusan National University
Yangsan Hospital, Yangsan, Republic of Korea *CR
4456 — D0196 Optic Nerve Capillaries Blood
Oxygenation in Normal and Primary OpenAngle Glaucoma Subjects. Vasile Diaconu, V.
Tran. Ecole D’optometrie, University of Montreal,
Montreal, QC, Canada
4458 — D0198 Optic Nerve Head Label-free
Microangiography: OCT-based Correlation
of Microstructure and Microvasculature in
Normal & Open Angle Glaucoma Subjects.
Lin An1, P. Li1, M. A. Johnstone2, R. K. Wang1, 2.
1
Bioengineering, University of Washington, Seattle,
WA; 2Ophthalmology, University of Washington,
Seattle, WA *CR
4459 — D0199 Effect of Cerebrospinal
Fluid Pressure on Central Retinal Artery
Hemodynamics: a Mathematical Model. Lucia
Carichino1, G. Guidoboni1, A. Amireskandari2,
B. Siesky2, A. Harris2. 1Mathematics, Indiana
University Purdue Univ, Indianapolis, IN;
2
Ophthalmology, Indiana University Sch of
Medicine, Indianapolis, IN *CR
4461 — D0201 A theoretical investigation of
the relationship between intraocular pressure,
cerebrospinal fluid pressure, arterial blood
pressure, blood flow autoregulation and retinal
hemodynamics. Giovanna Guidoboni1, A. Harris2,
S. Cassani1, L. Carichino1, A. Amireskandari2, B. A.
Siesky2. 1Mathematics, Indiana University Purdue
Univ, Indianapolis, IN; 2Ophthalmology, Indiana
University School of Medicine, Indianapolis, IN
*CR
4462 — D0202 Effect of Trabeculectomy on
Retinal Hemodynamics: Mathematical Modeling
of Clinical Data. Simone Cassani1, G. Guidoboni1,
I. Januleviciene3, L. Carichino1, B. Siesky2, L. A.
Tobe2, A. Amireskandari2, A. Harris2. 1Mathematics,
Indiana University Purdue Univ, Indianapolis,
IN; 2Ophthalmology, Indiana University Sch
of Medicine, Indianapolis, IN; 3Eye Clinic Of
Lithuanian University of Health Sciences, Kaunas,
Lithuania *CR
4463 — D0203 Effect of intraocular pressure
and arterial blood pressure on oxygen saturation
levels in the retina: a theoretical model. Julia
Arciero1, A. Harris2, G. Guidoboni1. 1Mathematics,
Indiana Univ-Purdue Univ Indianapolis,
Indianapolis, IN; 2Ophthalmology, Indiana
University, Indianapolis, IN *CR
4464 — D0204 Retinal Oximetry in Early
Primary Open Angle Glaucoma. Scott D.
Lawrence, P. D. Jani, K. Billow, J. Mwanza, I.
A. Falkenstein. Ophthalmology, Univ of North
Carolina at Chapel Hill, Chapel Hill, NC
4465 — D0205 Optic nerve head basal blood
flow increases early and then progressively
decreases in non-human primate experimental
glaucoma. Grant Cull, C. Piper, C. F. Burgoyne,
L. Wang. Devers Eye Institute, Legacy Research
Institute, Portland, OR *CR
4466 — D0206 Correlation between
papillomacular bundle thickness (PMBT)
and optic nerve blood flow in primary openangle, including normal-pressure, glaucoma.
Wataru Kobayashi1, K. Omodaka1, K. Togashi2, M.
Ryu1, T. Yuasa2, T. Nakazawa1. 1Ophthalmology,
Tohoku University, Sendai, Japan; 2Bio-Systems
Engineering, Yamagata University, Yonezawa,
Japan *CR
4467 — D0207 Optic Nerve Head Morphology
and Retrobulbar Blood Flow; Differences
between Glaucoma Patients with and without
Diabetes. Joshua G. Paschall, A. Harris, B. A.
Siesky, L. A. Tobe, A. Amireskandari, N. J. Kim,
C. R. Yung, B. M. Marek, D. WuDunn, J. Abrams.
Ophthalmology, Indiana University School of
Medicine, Indianapolis, IN *CR
4468 — D0208 Glaucoma Patients with
Diabetes Have Increasing Vascular Resistance
in the Ophthalmic and Central Retinal Arteries
Compared to Glaucoma Patients without
Diabetes. Nathaniel J. Kim, A. Harris, B. A. Siesky,
A. Amireskandari, J. G. Paschall, D. WuDunn,
L. B. Cantor, C. R. Yung, L. A. Tobe, J. Abrams.
Ophthalmology, Indiana University School of
Medicine, Indianapolis, IN *CR
4469 — D0209 Changes in Retinal Blood Flow
Correlate More Strongly with Changes in Optic
Nerve Head Morphology in Glaucoma Patients
with Diabetes Compared to Glaucoma Patients
without Diabetes. Annahita Amireskandari, A.
Harris, B. A. Siesky, N. J. Kim, B. M. Marek, J.
G. Paschall, L. B. Cantor, Y. P. Catoira-Boyle, J.
Abrams, L. A. Tobe. Ophthalmology, Indiana Univ
Sch of Medicine, Northville, MI *CR
4470 — D0210 Systemic Blood Pressure and
Ocular Perfusion Pressure affect Retrobulbar
Blood Flow Differently in Glaucoma Patients
of European and African Descent. Ariel Tyring,
A. Harris, B. A. Siesky, L. Racette, Y. P. CatoiraBoyle, A. Amireskandari, N. J. Kim, J. G. Paschall,
B. M. Marek, L. A. Tobe. Ophthalmology, Indiana
University School of Medicine, Indianapolis, IN
*CR
4471 — D0211 Retinal Oximetry in Primary
Open-Angle Glaucoma: Differences in Patients
of African and European Descent. Brent A.
Siesky, A. Harris, L. Racette, L. B. Cantor, L. A.
Tobe, Y. P. Catoira-Boyle, C. R. Yung, D. WuDunn,
J. M. Beach. Ophthalmology, Indiana Univ Sch of
Medicine, Zionsville, IN *CR
4472 — D0212 Systemic Blood Pressure and
Ocular Perfusion Pressure Affects Blood Flow
to the Optic Nerve Head in Glaucoma Patients
with Diabetes. Andrew H. Huck1, A. Harris1, B. A.
Siesky1, L. A. Tobe1, N. J. Kim1, A. Amireskandari1,
B. M. Marek1, I. Januleviciene2, B. M. Wirostko3,
G. J. Eckert4. 1Ophthalmology, Indiana
University School of Medicine, Indianapolis, IN;
2
Ophthalmology, Lithuanian University of Health
Sciences, Kaunas, Lithuania; 3Ophthalmology,
University of Utah, Park City, UT; 4Division
of Biostatistics, Indiana University School of
Medicine, Indianapolis, IN *CR
4473 — D0213 Effects of Rho Kinase
Inhibitor on mRNAs Associated with Glaucoma
Progression in Human Trabecular Meshwork
Cells Following Oxidative Stress. Hideki
Mochizuki, J. Hirata, Y. Kiuchi. Ophthalmology and
Visual Science, Hiroshima University, Hiroshima,
Japan
4474 — D0214 Burden of care associated with
Childhood Glaucoma: 4 year study. Jacey Hanna,
L. Ravindraraj, R. D. Fechtner, A. S. Khouri.
Ophthalmology, The Institute of Ophthalmology
and Visual Science, New Jersey Medical School,
Newark, NJ
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
291
Wednesday Posters
8:30 am – 10:15 am
4457 — D0197 Reduced Retinal Blood Flow
is Associated with Thinner Retinal Nerve
Fiber Layer in Glaucomatous Eyes with Single
Hemifield Damage. Mitra Sehi1, I. Goharian1, R.
Konduru2, O. Tan3, S. Srinivas2, S. R. Sadda2, D.
Huang3, D. S. Greenfield1. 1Ophthalmology, Bascom
Palmer Eye Institute, University of Miami, Palm
Beach Gardens, FL; 2Ophthalmology, Doheny Eye
Institute, University of Southern California, Los
Angeles, CA; 3Ophthalmology, Casey Eye Institute,
Oregon Health and Science University, Portland,
OR *CR, f
4460 — D0200 The effect of anthocyanins
and ginko biloba extract treatment in patients
with open-angle glaucoma depending on
the presence of diabetes mellitus. Yong Woo
Lee1, S. Shim1, J. Kim1, C. Choi1, K. Park2.
1
Ophthalmology, Sungkyunkwan University School
of Medicine,Kangbuk Samsung Hospital, Seoul,
Republic of Korea; 2Ophthalmology, Seoul National
University College of Medicine, Seoul, Republic
of Korea
4475 – 4496 – Wednesday – Posters
4475 — D0215 Evaluation of surface free
energy of Aurolab Aqueous Drainage Implant
(AADI) and its influence on cell adhesion
property, in comparison with Baerveldt Implant.
Chidambaranathan Gowri Priya1, K. Sivakumar2,
M. Pillai3, S. Krishnadas4, R. D. Sriram5, V.
Muthukkaruppan6. 1Department of Immunology
and Stem Cell Biology, Aravind Medical Research
Foundation, Dr. G. Venkataswamy Eye Research
Institute, Madurai, India; 2Polymer Division,
Aurolab, Madurai, India; 3Glaucoma Clinic,
Aravind Eye Hospital and Postgraduate Institute of
Ophthalmology, Madurai, India; 4Glaucoma Clinic,
Aravind Eye Hospital and Postgraduate Institute of
Ophthalmology, Madurai, India; 5Aurolab, Madurai,
India; 6Department of Immunology and Stem Cell
Biology, Aravind Medical Research Foundation, Dr.
G. Venkataswamy Eye Research Institute, Madurai,
India *CR
4476 — D0216 Targeting specific TGF-β
signaling pathways to prevent bleb fibrosis after
glaucoma drainage device surgery. Christian
K. Vorwerk1, V. Sokalskis2, A. Zabelyshenskiy2, H.
Thieme1, L. Choritz1, 2. 1Dept of Ophthalmology,
Otto von Guericke University, Magdeburg,
Germany; 2Dept of Ophthalmology, University
Medical Center, Mainz, Germany
4477 — D0217 Retrospective study of
congenital glaucoma surgical treatment. Hector
Bello Lopez Portillo, J. Jimenez-Roman, M. TuratiAcosta, M. García-Huerta, R. Castañeda Diez, F.
Gil Carrasco, C. Isida Llerandi. Asociacion para
Evitar la Ceguera en Mexico, Mexico, Mexico
Wednesday Posters
8:30 am – 10:15 am
4478 — D0218 Intraocular Pressure Reduction
of Modified 360-degree Suture Trabeculotomy
in Intent-to-treat Eyes. Daisuke Shiba, T. Ono, N.
Ozeki, K. Yuki, K. Tsubota. Ophthalmology, Keio
University, Shinjuku-ku, Japan *CR
4479 — D0219 Evaluation of Dose Effect
of ALK-5 Inhibitor and Controlled Delivery
with Novel Pentablock Polymer in Glaucoma
Filtration Surgery. Hiroshi Nakamura1, 2, J. J.
Dunmire1, V. Sutariya2, 3, M. Hewit2, D. Wehrung2,
S. Patel4, A. K. Mitra4. 1Ophthalmology, Summa
Health System, Akron, OH; 2Pharmaceutical
sciences, Northeast Ohio Medical University,
Rootstown, OH; 3Pharmaceutical sciences,
University of South Florida, Tampa, FL;
4
Pharmaceutical sciences, University of MissouriKansas City, Kansas City, MO
4480 — D0220 The effect of steroid and matrix
metalloproteinase inhibitor on bleb survival
in an experimental animal model. Alastair
Lockwood1, 2, A. Mohamed Ahmed1, 2, A. Khalili1, 2,
S. Awwad1, 2, G. Sharma1, 2, S. Brocchini1, 2, P. T.
Khaw1. 1NIHR Moorfields Biomedical Research
Centre, London, United Kingdom; 2UCL School
of Pharmacy, University College London, London,
United Kingdom *CR
4481 — D0221 Attenuation of Glaucoma
Filtration Surgery-induced Scarring by an
FDA-approved Histone Deacetylase Inhibitor,
Suberoylanilide Hydroxamic Acid (SAHA). Ajay
Sharma, J. W. Brubaker, M. Reyes, J. T. Rodier,
A. Tandon, R. R. Mohan. Mason Eye Institute,
University of Missouri, Columbia, MO
4482 — D0222 Surgical Outcomes of
Augmented MMC Trabeculectomy After
Failed Seton Surgery. Jose A. Paczka1, 3, L. A.
Giorgi-Sandoval2, 3, M. A. Ramos-Hernandez1, J.
Jimenez-Roman2, 3, A. Merikansky2. 1Oftalmologia,
University of Guadalajara, Guadalajara, Mexico;
2
Oftalmologia, Asistencia e Investigacion en
Glaucoma, A.C., Guadalajara, Mexico; 3Glaucoma,
Global Glaucoma Institute, Guadalajara, Mexico
4483 — D0223 Influence of endothelin-1 in
aqueous humor on IOP and filtration surgery
outcome. Lars Choritz1, 2, B. Mahmoodi1, M.
Machert1, N. Pfeiffer1, H. Thieme2. 1Ophthalmology,
University Medical Center, Mainz, Germany;
2
Ophthalmology, University Clinic, Otto von
Guericke University, Magdeburg, Germany *CR
4484 — D0224 A New Technique for Glaucoma
Surgery: Scorolli Trabeculectomy. Lucia
Scorolli1, E. Meduri2, A. De Leo5, R. Meduri3, E.
Zere4, P. Piccaluga5, S. Scalinci1. 1Ophthalmology, S
Orsola Malpighi Hospital Bologna, Bologna, Italy;
2
Medical School, University of Sophia, Sophia,
Bulgaria; 3IE Business School, Madrid, Spain;
4
Ophthalmology, Univesity La Sapienza, Rome,
Italy; 5Molecular Pahology, University of Bologna,
Bologna, Italy
4485 — D0225 Functional and anatomic
outcomes following endocyclophotocoagulation
(ECP) surgery for neo-vascular glaucoma as
compared to routine glaucoma care. Kyle V.
Marra1, S. Wagley2, A. F. Omar3, J. G. Arroyo1.
1
Beth Israel Deaconess Medical Center, Boston,
MA; 2College of Human Medicine - Michigan
State University, East Lansing, MI; 3Joslin Diabetes
Center, Boston, MA
4486 — D0226 Efficacy of Catheter Assisted
360° Trabeculotomy in Primary Congenital
Glaucoma (PCG). Erika Wandel1, D. Dave1, M.
Vora2, C. H. Marcus3, R. F. Rothman3, T. Frempong1,
D. D. Hayes3, A. Angelilli3, J. B. Serle1, 3.
1
Ophthalmology, Mount Sinai Hospital, New York,
NY; 2Ophthalmology, North Shore-Long Island
Jewish Health System, Manhasset, NY; 3Glaucoma
Consultants of Long Island, Bethpage, NY *CR
4487 — D0227 Ahmed glaucoma valve FP7
and FP8 in pediatric glaucoma: A randomized
clinical trial. Bruno L. Esporcatte, C. F. Netto,
T. Tanno, L. S. Melo, I. M. Tavares, C. Rolim de
Moura. Glaucoma, Federal University of São Paulo,
São Paulo, Brazil f
4488 — D0228 A model to measure surgical
outflow using a two-tubed experimental
glaucoma drainage device. Craig Ross, D.
Nguyen, S. S. Pandav, Y. Li, J. G. Crowston, M.
A. Coote. Centre for Eye Research Australia,
University of Melbourne, Royal Victorian Eye and
Ear Hospital, East Melbourne, VIC, Australia
4490 — D0230 Comparision of surgical
outcomes of Express Shunt and Ahmed Valve
in Neovascular Glaucoma. Huseyin Kadikoy, B.
A. Hughes, J. Tannir, R. Momi. Ophthalmology,
Kresge Eye Institute, Royal Oak, MI
4491 — D0231 A Novel Minimally Invasive
Drainage Implant (the MIDI-Arrow): One-Two
Year Follow Up. Paul F. Palmberg1, J. F. Batlle3,
R. Alburquerque3, A. Corona-Peralta3, I. Riss4,
R. Parrish1, E. Arrieta2, J. A. Parel2. 1Biophysics
(Ophthalmology), University of Miami, Miami,
FL; 2Ophthalmology, University of Miami, Miami,
FL; 3Centro Laser, Santo Domingo, Dominican
Republic; 4Pole Ophtalmologogique, Clinique
Mutualiste, Pessac, France *CR, f
4492 — D0232 Surgical Outcomes in First
25 Canaloplasties and Impact of Growing
Experience on Complications. Elisabeth P.
Aponte, J. Eisengart. Ophthalmology, Cleveland
Clinic Cole Eye Institute, Cleveland, OH
4493 — D0233 Review of the Success Rate
of an Intraoperative Modified Bleb Revision
Technique. Priya Gupta, K. S. Arora, C. Lee, D.
S. Friedman. Wilmer Eye Institute, Johns Hopkins
Hospital, Baltimore, MD *CR
4494 — D0234 Clinical and Tomographic
Findings in Filtering Blebs Undergoing Digital
Compression. Miriam A. Ramos-Hernandez2,
M. A. Ramos-Hernandez2, E. Chavez2, L. A.
Giorgi-Sandoval1, J. A. Paczka1, 2. 1Asistencia e
Investigacion en Glaucoma, A.C., Guadalajara,
Mexico; 2Instituto de Oftalmologia y Ciencias
Visuales, Guadalajara, Mexico
4495 — D0235 Cyclodialysis incidence in
anterior segment surgery in an Ophthalmology
Referral Center. Rodrigo Bolanos1, A. Navas3, E.
O. Graue-Hernández3, A. J. Ramirez-Miranda3,
J. Ledesma Gil2. 1Research Unit, Inst of Ophthal
Conde de Valenciana, Mexico City, Mexico;
2
Glaucoma, Instituto de Oftalmologia Conde de
Valenciana, Mexico DF, Mexico; 3Cornea An
Refractive Surgery, Instituto de Oftalmologia
Conde de Valenciana, Mexico DF, Mexico *CR
4496 — D0236 Optimal administration route
of bevacizumab after glaucoma filtration
surgery. Karolien P. Hollanders1, T. Van Bergen1,
D. Sijnave1, S. Van de Velde1, E. Vandewalle1, L.
K. Moons2, I. Stalmans1. 1Neuroscience, Lab of
Ophthalmology, KULeuven, Leuven, Belgium;
2
Biology, KULeuven, Leuven, Belgium *CR
4489 — D0229 Comparison of Early PostOperative Challenges in P200 Ex-PRESS Shunts
and Conventional Trabeculectomies. Maheen
Haque, B. A. Hughes, J. Tannir, R. Momi, C. Kim.
Kresge Eye Institute/Wayne State University,
Detroit, MI
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
292
Wednesday – Papers/Minisymposium – 4497 – 4508
6B
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Glaucoma
424 Genetics I
Moderators: John H. Fingert and
Andrew J. Lotery
4497 — 11:00 Genome-wide Association Study
and Meta-Analysis of Intraocular Pressure in
Primary Open-Angle Glaucoma Cases and
Controls in the NEIGHBOR, GLAUGEN and
AMD-MMAP Studies. Sayoko E. Moroi1, A. B.
Ozel2, D. M. Reed1, K. E. Branham1, M. A. Hauser3,
L. R. Pasquale4, J. L. Wiggs4, J. E. Richards1, J. Z.
Li2. 1Ophthalmology & Visual Sciences, Univ of
Michigan-Kellogg Eye Ctr, Ann Arbor, MI; 2Human
Genetics, University of Michigan, Ann Arbor, MI;
3
Center for Human Genetics, Duke University
School of Medicine, Durham, NC; 4Department
of Ophthalmology, Harvard Medical School,
Massachusetts Eye and Ear Infirmary, Boston, MA
*CR
4499 — 11:30 Runs of Homozygosity Across
the Whole Genome Suggests two Novel Genes
in Primary Congenital Glaucoma. Subhabrata
Chakrabarti1, S. Ganguly3, M. Kabra1, A. K.
Mandal2, S. Senthil1, I. Kaur1, P. P. Majumder4, 3.
1
Brien Holden Eye Research Centre, LV Prasad Eye
Institute, Hyderabad, India; 2Jasti V Ramanamma
Childrens Eye Care Centre, L V Prasad Eye
Institute, Hyderabad, India; 3Department of Human
Genetics, Indian Statistical Institute, Kolkata,
India; 4National Institute of Biomedical Genomics,
Kalyani, India
4501 — 12:00 The role of SIX6 in primary
open-angle glaucoma. Michael A. Hauser1, 2, M.
Ulmer1, Y. Liu3, E. Davis3, N. Katsanis3, Y. Liu1,
L. R. Pasquale4, J. L. Wiggs4, A. E. Ashley-Koch1,
R. Allingham2. 1Medicine, Duke Univ Medical
Center, Durham, NC; 2Ophthalmology, Duke Univ
Medical Center, Durham, NC; 3Cell Biology, Duke
University, Durham, NC; 4Ophthalmology, Harvard
Medical School, Boston, MA *CR
4502 — 12:15 A genome-wide association
study of intra-ocular pressure identifies a
novel association in the gene FAM125B in the
TwinsUK cohort. Abhishek Nag1, P. G. Hysi1,
C. Venturini2, 1, E. Yonova1, K. M. Williams1, C.
J. Hammond1. 1Department of Twin Research,
King’s College London, London, United Kingdom;
2
Institute of ophthalmology, University College
London, London, United Kingdom
4503 — 12:30 Identification of further novel
genome wide significant loci for open angle
glaucoma blindness utilizing the Australian
and New Zealand Registry of Advanced
Glaucoma. Jamie E. Craig1, A. W. Hewitt2, 1,
S. Graham3, P. R. Healey4, R. J. Casson5, P.
Mitchell4, J. Landers1, S. MacGregor6, D. A.
Mackey2, K. P. Burdon1. 1Ophthalmology, Flinders
University, Bedford Park, Adelaide, SA, Australia;
2
Ophthalmology, Lions Eye Institute, Perth, WA,
Australia; 3Ophthalmology, Macquarie University,
Sydney, NSW, Australia; 4Ophthalmology,
Sydney University, Sydney, NSW, Australia;
5
Ophthalmology, Adelaide University, Adelaide,
SA, Australia; 6Queensland Institute of Medical
Research, Brisbane, QLD, Australia *CR
6C
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Retina
425 AMD: Novel and
Combination Therapies
Moderators: Susanne Binder and Pravin U. Dugel
4504 — 11:00 Anti-VEGF Gene Therapy for
Wet AMD: Safety and Tolerability of Subretinal
Delivery in a Phase I/II Clinical Trial. Ian
Constable1, 2, C. Pierce2, S. K. Somasundaram2,
M. Lai1, 2, T. W. Chalberg3, M. S. Blumenkranz4,
R. Samulski5, E. P. Rakoczy1, 2. 1Centre for
Ophthalmology and Visual Sciences, University
of Western Australia, Perth, WA, Australia; 2Lions
Eye Institute, Perth, WA, Australia; 3Avalanche
Biotechnologies, San Francisco, CA; 4Byers Eye
Institute at Stanford, Palo Alto, CA; 5Pharmacology
and Gene Therapy Center, University of North
Carolina, Chapel Hill, NC *CR, f
4505 — 11:15 Phase I, Masked, PlaceboControlled, Single and Multiple Ascending
Intravenous Dose Studies Evaluating Systemic
and Ocular Safety, Tolerability, and Visual
Acuity Effects of RN6G (PF-04382923) in
Subjects with Dry, Age-Related Macular
Degeneration (ARMD). Brian B. Berger1, P.
D. Garzone2, I. Gunderson1, P. M. Fanning2, G.
Wong2, K. H. Liao2, S. Y. Hua2, J. Lin2. 1Retina
Research Center, Austin, TX; 2Pfizer Inc., South San
Francisco, CA *CR, f
4506 — 11:30 A Phase 2 Double-masked,
Placebo-controlled, Dose Ranging Study of
Emixustat Hydrochloride (ACU-4429) in
Subjects with GA Associated with Dry AMD.
Pravin U. Dugel1, R. L. Novack2, K. G. Csaky3, P.
P. Richmond4, D. G. Birch5, R. Kubota6. 1Retinal
Consultants of Arizona, Ltd, Phoenix, AZ; 2RetinaVitreous Associates Medical Group, Beverly Hills,
CA, Beverly Hills, CA; 3Texas Retina Associates,
Dallas, TX, Dallas, TX; 4Central Florida Retina,
Orlando, FL, Orlando, FL; 5Retina Foundation of
Southwest, Dallas, TX, Dallas, TX; 6Acucela Inc.,
Seattle, WA, Seattle, WA *CR, f
4507 — 11:45 Photodynamic Therapy vs
Combination Therapy in Polypoidal Choroidal
Vasculopathy: Changes of Aqueous Vascular
Endothelial Growth Factor. Meeyon Lee1, W. Lee2.
1
Chung ang University hospital, Seoul, Republic of
Korea; 2Seoul St. Mary hospital, Seoul, Republic of
Korea *CR, f
4508 — 12:00 Twelve Months Results
Comparing Ranibizumab or Bevacizumab
Treatment in Patients with Neovascular Agerelated Macular Degeneration(AMD) Multicenter
Anti-VEGF Trial in Austria The Manta Study.
Susanne Binder1, I. Krebs1, L. Schmetterer2.
1
Ophthalmology, Rudolf Foundation Clinic, Vienna,
Austria; 2Department of Clinical Pharmacology,
Medical University, Vienna, Austria f
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
293
Wednesday Papers/
Minisymposium
11:00 am – 12:45 pm
4498 — 11:15 Molecular mechanisms in
Primary Glaucoma: POAG-associated variant
disrupts microRNA regulation of CDKN2B
expression. Terry Gaasterland1, 2, A. N. Dubinsky3,
A. R. La Spada3, 8, K. Mansouri4, 10, K. H. Willert8, 9,
D. E. Gaasterland5, M. A. Hauser6, L. R. Pasquale7,
J. L. Wiggs7, R. N. Weinreb10. 1Institute for Genomic
Medicine, Univ of California San Diego, La Jolla,
CA; 2Marine Biology Research Division, Univ of
California San Diego, La Jolla, CA; 3Department of
Pediatrics, Univ of California San Diego, La Jolla,
CA; 4University of Geneva, Geneva, Switzerland;
5
Ophthalmology, Potomac, MD; 6Department
of Medicine, Duke University, Durham, NC;
7
Massachusetts Eye and Ear Institute, Harvard,
Cambridge, MA; 8Cellular and Molecular Medicine;
Neurosciences, Univ of California San Diego, La
Jolla, CA; 9Sanford Consortium for Regenerative
Medicine, La Jolla, CA; 10Hamilton Glaucoma
Center, Univ of California San Diego, La Jolla, CA
*CR
4500 — 11:45 Genetic factors and pathways
affecting retinal nerve fiber layer thickness.
Cristina Venturini1, 2, P. G. Hysi2, A. Nag2, E.
Yonova2, J. Wang3, 4, T. Y. Wong5, 6, P. R. Healey4,
P. Mitchell4, C. J. Hammond2, A. C. Viswanathan7,
8 1
. Genetics, UCL, Institute of Ophthalmology,
London, United Kingdom; 2Twin Research &
Epidemiology Research, King’s College London,
London, United Kingdom; 3Centre for Eye Research
Australia (CERA), Department of Ophthalmology,
University of Melbourne, Melbourne, NSW,
Australia; 4Department of Ophthalmology,
University of Sydney Centre for Vision Research,
Sydney, NSW, Australia; 5Epidemiology and
Public Health, National University of Singapore,
Singapore, Singapore; 6Singapore Eye Research
Institute, Singapore, Singapore; 7Glaucoma Service,
Moorfield Eye Hospital, London, United Kingdom;
8
NIHR Biomedical Research Centre, Moorfield
Eye Hospital and UCL Institute of Ophthalmology,
London, United Kingdom *CR
4509 – 4524 – Wednesday – Papers/Minisymposium
4509 — 12:15 Long-Term and Lasting
Outcomes of Combination Treatment for
Age-Related Macular Degeneration with
Photodynamic Therapy and Intravitreal
Injection of Anti-Vascular Endothelial Growth
Factor. Colleen M. McLellan, R. Silva-Garcia, K.
W. Small. Molecular Insight Research Foundation,
Glendale, CA *CR
6E
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Retina
426 Macular Disease Other
Than AMD II
Moderators: William F. Mieler and
K. Bailey Freund
4510 — 11:00 Occult Central Serous
Chorioretinopathy. K Bailey Freund1, 2, D.
Warrow3, R. Gallego-Pinazo1, 5, Q. V. Hoang4.
1
Ophthalmology, Vitreous Retina Macula
Consultants New York, New York, NY;
2
Ophthalmology, New York University, New
York, NY; 3Ophthamology, New York Eye and
Ear Infirmary, New York, NY; 4Ophthalmology,
Columbia University, New York, NY;
5
Ophthalmology, University and Polytechnic
Hospital La Fe, Valencia, Spain *CR
Wednesday Papers/
Minisymposium
11:00 am – 12:45 pm
4511 — 11:15 Effect of Somatostatin on the
expression of tight junctions and urokinase
plasminogen activator receptor in human retinal
pigment epithelial cells. Alex Fonollosa1, 2, J.
Artaraz1, A. Martinez-Berriotxoa1, E. Vecino2.
1
Ophthalmology, Hospital de Cruces, Portugalete,
Spain; 2Grupo de Oftalmobiologia Experimental,
Bilbao, Spain
4512 — 11:30 Selective Laser Photocoagulation
of Peripheral Non-perfused Retinal Areas
May Improve the Vision in Patients with
Central Retinal Vein Occlusion Treated with
Ranibizumab. Matus Rehak1, A. Franke2, P. M.
Wiedemann1. 1Department of Ophthalmology,
University of Leipzig, Leipzig, Germany; 2Clinical
Trial Centre (ZKS) Leipzig, University of Leipzig,
Leipzig, Germany *CR, f
4513 — 11:45 Macular Bruchs Membrane
Defects and Axial Length: Association with
Gamma Zone and Delta Zone in Peripapillary
Region. Jost B. Jonas1, K. Ohno-Matsui2,
R. F. Spaide3, L. Holbach4, S. Panda-Jonas1.
1
Ophthalmology, Medical Faculty MannheimHeidelberg, Mannheim, Germany; 2Department
of Ophthalmology and Visual Science, Tokyo
Medical and Dental University, Tokyo, Japan;
3
Vitreous-Retina-Macula Consultants of New
York and the LuEsther T. Mertz Retinal Research
Center, Manhattan Eye, Ear, and Throat Hospital,
New York, NY; 4Department of Ophthalmology,
Friedrich-Alexander University Erlangen-Nürnberg,
Erlangen, Germany *CR
4514 — 12:00 Treatment Experience with
Intravitreal Aflibercept Injection (IAI) After
Switching to PRN Dosing in Patients with
Macular Edema Secondary to Central Retinal
Vein Occlusion (CRVO). David M. Brown1, F. G.
Holz2. 1Retina Consultants of Houston, Houston,
TX; 2Department of Ophthalmology, University of
Bonn, Bonn, Germany *CR, f
4515 — 12:15 Two-Year Results of the
COPERNICUS Study Evaluating Intravitreal
Aflibercept Injection (IAI) for Macular Edema
Secondary to Central Retinal Vein Occlusion
(CRVO). W. Lloyd Clark. Palmetto Retina Center,
West Columbia, SC *CR, f
4516 — 12:30 Eighteen-Month Results of
the GALILEO Study Evaluating Intravitreal
Aflibercept Injection (IAI) for Macular Edema
Secondary to Central Retinal Vein Occlusion
(CRVO). Yuichiro Ogura1, J. Korobelnik2, J.
Roider3, R. Vitti4, F. G. Holz5, F. Hiemeyer6, B.
Stemper6, O. Zeitz6, R. Sandbrink6. 1Department
of Ophthalmology, Nagoya City University
Medical School, Nagoya, Japan; 2Department
of Ophthalmology, CHU Bordeaux, Universite
Bordeuax, Bordeaux, France; 3Department of
Ophthalmology, University Medical Center
Schleswig-Holstein, Kiel, Germany; 4Regeneron
Pharmaceuticals Inc., Tarrytown, NY; 5Department
of Ophthalmology, University of Bonn, Bonn,
Germany; 6Bayer Healthcare, Berlin, Germany
*CR, f
606/607
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Immunology/Microbiology
427 Ocular Immune Responses
Moderators: Holly L. Rosenzweig and
Thomas Langmann
4517 — 11:00 Loss of MicroRNA-124
and MicroRNA-126 expression regulates
inflammatory microglial activation in inherited
retinal degeneration. Thomas Langmann1, 2, C.
Moehle3, M. Karlstetter1, B. H. Weber2. 1Department
of Ophthalmology, University of Cologne, Cologne,
Germany; 2Institute of Human Genetics, University
of Regensburg, Regensburg, Germany; 3Center of
Excellence for Fluorescent Bioanalytics, University
of Regensburg, Regensburg, Germany
4518 — 11:15 Mice lacking TNFR1 develop
less angiogenesis during late stage experimental
autoimmune uveoretinitis (EAU). Madeleine
Stimpson1, J. Liu1, D. A. Copland1, T. K. Khera1,
A. D. Dick1, 2. 1Academic Unit of Ophthalmology,
University of Bristol, Bristol, United Kingdom;
2
Cellular and Molecular Medicine, University of
Bristol, Bristol, United Kingdom *CR
4519 — 11:30 Differential effects of TLR3 activated RPE on retinal microglia and
blood-derived monocytes. Alexa K. Klettner1,
T. Hamann1, S. Wilker1, C. Berg1, K. Schlüter1, R.
Lucius2, M. Rolf2, J. Roider1. 1Ophthalmology, Univ
of Kiel, Kiel, Univ Medical Center, Kiel, Germany;
2
Anatomy, University of Kiel, Kiel, Germany *CR
4520 — 11:45 Demonstration of Donor T cell
Recruitment and Correlation with Inflammatory
Cytokine Presence in Experimental Ocular
Graft-versus-Host Disease. Samantha Herretes1,
J. C. Murillo1, D. Ross2, H. Barreras2, Y. Tan1, A. M.
Saeed1, A. Gonzalez1, C. Betancurt1, R. B. Levy2, V.
L. Perez1, 2. 1Ophthalmology, Bascom Palmer Eye
Inst, Univ of Miami, Miami, FL; 2Immunology and
Microbiology, University of Miami, Miami, FL *CR
4521 — 12:00 Monophasic PDSAg-induced
EAU dominates over relapsing R14-induced
EAU. Ulrike Kaufmann, M. Diedrichs-Möhring,
G. Wildner. Ophthalmology, Clinic of the LudwigMaximilians-University, Munich, Germany
4522 — 12:15 Inhibition of Vascular
Endothelial Growth Factor Ameliorates Ocular
Allergy in the Murine Model. Daniel R. Saban1,
R. Dana2, H. Lee2, T. Blanco1. 1Ophthalmology,
Duke University School of Medicine, Durham, NC;
2
Ophthalmology, Schepens Eye Res Inst, Mass. Eye
& Ear, Harvard Medical School, Boston, MA *CR
4523 — 12:30 Translational Modeling of
Calpain-5 Vitreoretinopathy Mechanisms
in Mice. Vinit B. Mahajan1, 2, K. J. Wert3, J. M.
Skeie1, 2, S. H. Tsang4. 1Ophthalmology, University
of Iowa, Iowa City, IA; 2Omics Laboratory,
University of Iowa, Iowa City, IA; 3Institute of
Human Nutrition, Columbia University, New York,
NY; 4Ophthalmology, Columbia University, New
York, NY
608
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Anatomy/Pathology
428 Uveal Melanoma: Experimental
Therapeutics
Moderators: Hans Grossniklaus, Sarah E.
Coupland and Arun D. Singh
4524 — 11:00 Microphthalmia-associated
transcription factor (MITF) and Steroid
Receptor Coactivator (SRC)-3 cooperate to
promote proliferation, survival and metabolism
in Gα-mutant uveal melanoma (UM) cells.
Vassiliki Poulaki1, 2, S. Chew3, 4, B. He3, 4, V.
Eedunuri5, M. M. Jager6, B. W. O’Malley4,
N. Mitsiades3, 4. 1Ophthalmology, Boston VA
Healthcare System, Boston, MA; 2Ophthalmology,
Boston University, Boston, MA; 3Medicine,
Baylor College of Medicine, Houston, TX;
4
Molecular and Cellular Biology, Baylor College
of Medicine, Houston, TX; 5Adrienne Helis Malvin
Medical Research Foundation, New Orleans, LA;
6
Ophthalmology, Leiden University Medical Center,
Leiden, Netherlands
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
294
Wednesday – Papers/Minisymposium – 4525 – 4541
4525 — 11:15 Uveal Melanoma Cells Are
Inhibited by AICAR Partially Through
Activation of AMP-Dependent Kinase. Ahmad
Al Moujahed1, F. Nicolaou2, T. D. Papakostas1,
J. W. Miller1, E. S. Gragoudas1, D. Vavvas1.
1
Ophthalmology, Massachusetts Eye and Ear
Infirmary, Harvard Medical School, Boston, MA;
2
Pediatric Surgery Laboratories, Massachusetts
General Hospital, Boston, MA *CR
4526 — 11:30 SRPK1 Inhibition, As A Way Of
Targeting Pro-Angiogenic VEGF-A Production
In Ocular Tumours. Melissa V. Gammons1, S. E.
Coupland3, A. D. Dick2, D. O. Bates1. 1Department
of Physiology and Pharmacology, University
of Bristol, Bristol, United Kingdom; 2School of
Clinical Sciences and School of Cellular and
Molecular medicine, University of Bristol, Bristol,
United Kingdom; 3Department of Molecular and
Clinical Cancer Medicine, University of Liverpool,
Liverpool, United Kingdom *CR
4527 — 11:45 Targeting Uveal Melanoma
Response to Hypoxia. Dudi Shneor1, 2, A.
Honigman2, J. Pe’er1, S. Frenkel1. 1Ophthalmology,
Hadassah-Hebrew University Medical Center,
Jerusalem, Israel; 2Biochemistry and Molecular
Biology, IMRIC, The Hebrew University-Hadassah
Medical School, Jerusalem, Israel
4528 — 12:00 Efficacy of A Novel Anti-tumor
Agent KCN1 in the Control of Ocular Melanoma
In vitro and In vivo. Qing Zhang1, 2, H. Yang1,
S. Kaluz3, E. G. Van Meir3, 4, H. E. Grossniklaus1,
5 1
. Ophthalmology, Emory University School of
Medicine, Atlanta, GA; 2Ophthalmology, Central
South University Xiangya School of Medicine,
Changsha, China; 3Neurosurgery, Winship Cancer
Institute, Emory University School of Medicine,
Atlanta, GA; 4Hematology and Medical Oncology,
Emory University School of Medicine, Atlanta, GA;
5
Pathology, Emory University School of Medicine,
Atlanta, GA *CR
4530 — 12:30 Identification of regulators
of uveal melanoma metastasis through whole
exome sequencing. Sarah Lake1, B. E. Damato2,
H. Kalirai1, L. Olohan3, X. Liu3, S. E. Coupland1.
1
Molecular And Clinical Cancer Medicine,
University of Liverpool, Liverpool, United
Kingdom; 2Royal Liverpool University Hospital,
Liverpool, United Kingdom; 3Centre for Genomic
Research, University of Liverpool, Liverpool,
United Kingdom
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Lens
429 A Global View of Posterior Capsule
Opacification - Minisymposium
Posterior Capsule Opacification (PCO) is the most
common complication of cataract surgery, which
essentially forms by a lens wound-healing response
induced by surgical trauma. Despite advances in
artificial lens implants to delay PCO formation,
significant numbers of patients still experience
visual deterioration that requires laser surgery to
resolve the problem. PCO is therefore far from
eradicated and requires communication between
industry, clinicians and scientists to best understand
the problem and determine novel strategies to
delay or eliminate PCO formation. The proposed
minisymposium will bring together these different
communities to discuss this important problem.
Moderators: Michael Wormstone, Melinda K.
Duncan and Steven Bassnett
— 11:00 Introduction
4531 — 11:05 Polymers, Barriers and Haptics:
The Development of IOLSs in the Prevention
of PCO. David Spalton. Consulting Rooms, King
Edward VII Hospital, London, United Kingdom
*CR
4532 — 11:30 Differentiation in the Lens:
Implications for PCO. Linda Musil. Biochemistry
& Molecular Biology, Oregon Health & Science
Univ, Portland, OR
4533 — 11:55 Lens Cell/ECM Interactions in
PCO. Melinda K. Duncan. Biological Sciences,
University of Delaware, Newark, DE
4534 — 12:20 TGFbeta and PCO: Why Old
Bags Wrinkle. Michael Wormstone. School of
Biological Sciences, University of East Anglia,
Norwich, United Kingdom *CR
4536 — 11:15 Endothelial Progenitor Cells
in Bone Marrow, Blood, and Retina Respond
Dynamically to Murine Oxygen-Induced
Retinopathy. Bliss E. O’Bryhim1, 2, R. White1, R. C.
Symons1, 3. 1Ophthalmology, University of Kansas
Medical Center, Kansas City, KS; 2Molecular &
Integrative Physiology, Univ of Kansas Medical
Center, Kansas City, KS; 3Department of Surgery,
University of Melbourne, Melbourne, VIC,
Australia
4537 — 11:30 Neuronal Sirtuin1 mediates
retinal vascular regeneration in retinopathy. Jing
Chen, A. Juan, C. G. Hurst, D. T. Pei, J. Joyal, L.
Evans, Z. Cui, A. Stahl, P. Sapieha, L. E. Smith.
Ophthalmology, Harvard Med Sch Children’s Hosp,
Boston, MA
4538 — 11:45 Vascular Protective Effects of
Candesartan In Ischemic Retinopathy. Azza B.
El-Remessy1, 2, A. Y. Shanab1, 2, S. Matragoon1, 2, S.
C. Fagan1, 2. 1Clin & Experimental Therapeutics,
University of Georgia, Augusta, GA; 2VA Medical
Center, Augusta, GA *CR
4539 — 12:00 Senescent endothelial progenitor
cells show impaired vasoregenerative capacity
in the ischemic retina. Emma Reid1, R. J. Medina1,
M. O’Doherty1, C. L. O’Neill1, S. Wilson1, J.
Guduric-Fuchs1, J. Neisen2, D. J. Waugh2, D. A.
Simpson1, A. W. Stitt1. 1Centre for Vision & Vascular
Science, Queen’s University Belfast, Belfast,
United Kingdom; 2Centre for Cancer Research and
Cell Biology, Queen’s University Belfast, Belfast,
United Kingdom *CR
4540 — 12:15 Lack of Cyp1B1 Promotes
the Proliferative and Migratory Phenotype of
Perivascular Supporting Cells. Nader Sheibani1,
T. L. Palenski1, C. M. Sorenson2. 1Ophthalmology
and Visual Sciences, Univ of Wisconsin-Madison,
Madison, WI; 2Pediatrics, Uinversity of Wisconsin,
Madison, WI
4541 — 12:30 Laminin Regulation of Retinal
Vascularization: Role in Astrocyte Migration
and Differentiation. William J. Brunken1, 2,
G. Bachay1, 2, S. Biswas1, 2, G. Gnanaguru1, 2.
1
Ophthalmology and Cell Biology, SUNY
Downstate Medical Center, Brooklyn, NY; 2SUNY
Eye Institute, Brooklyn, NY
611-614
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Retinal Cell Biology
430 Physiologic Vascularization
in Retinopathies
Moderators: Azza B. El-Remessy and Alan W. Stitt
4535 — 11:00 Inhibiting the Ras Pathway
Prevents Ocular Neovascularization by
Repressing Tip Cell Sprouting. Peter D.
Westenskow, T. Kurihara, E. Aguilar, M. Webb,
C. M. Wittgrove, S. K. Moreno, M. Friedlander.
Department of Cell Biology, The Scripps Research
Institute, La Jolla, CA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
295
Wednesday Papers/
Minisymposium
11:00 am – 12:45 pm
4529 — 12:15 NFkB Inhibition in Uveal
Melanoma - Contrariety of in vitro vs. in vivo
Results. Shahar Frenkel1, D. Shneor2, 1, J. Pe’er1,
A. Honigman2. 1Ophthalmology, Hadassah-Hebrew
University Medical Center, Jerusalem, Israel;
2
Biochemistry and Molecular Biology, IMRIC,
The Hebrew University-Hadassah Medical School,
Jerusalem, Israel
609
4542 – 4559 – Wednesday – Papers/Minisymposium
615-617
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Clinical/Epidemiologic Research
431 Eye Care: Who’s Not Getting It and
Why It Matters
Moderators: Pradeep Y. Ramulu and
Nakul Shekhawat
4542 — 11:00 Does government assistance
improve access for low-income individuals to
eye care providers? Chris J. Hong1, G. E. Trope2,
Y. M. Buys2, B. E. Robinson4, Y. Jin2, 3. 1Department
of Medicine, University of Ottawa, Ottawa, ON,
Canada; 2Department of Ophthalmology and
Vision Sciences, University of Toronto, Toronto,
ON, Canada; 3Dalla Lana School of Public Health,
University of Toronto, Toronto, ON, Canada;
4
School of Optometry, University of Waterloo,
Waterloo, ON, Canada *CR
Wednesday Papers/
Minisymposium
11:00 am – 12:45 pm
4543 — 11:15 The Association of Vision Loss
with Work Status in the United States. Cheryl
Sherrod2, 1, K. D. Frick3, 5, P. Y. Ramulu4, 1. 1Dana
Center for Preventive Ophthalmology, Wilmer
Eye Institute at Johns Hopkins, Baltimore, MD;
2
Preventive Medicine, Johns Hopkins Bloomberg
School of Public Health, Baltimore, MD; 3Health
Policy & Management, Johns Hopkins Bloomberg
School of Public Health, Baltimore, MD;
4
Glaucoma Division, Wilmer Eye Institute at Johns
Hopkins, Baltimore, MD; 5International Health,
Johns Hopkins Bloomberg School of Public Health,
Baltimore, MD *CR
4544 — 11:30 Despite Possessing Health
Insurance, Large Disparities Exist in Likelihood
of Visits to Eye Care Providers Across U.S.
Sociodemographic Groups. Patricia A. Pleplakon1, C. A. Andrews1, D. C. Musch1, 2, P. P.
Lee1, J. D. Stein1. 1Ophthalmology and Visual
Sciences, University of Michigan, Ann Arbor, MI;
2
Epidemiology, University of Michigan, Ann Arbor,
MI *CR
4545 — 11:45 The global burden of potential
productivity loss from presbyopia. Susan M.
Joy1, K. D. Frick1, K. S. Naidoo2, D. A. Wilson2,
B. A. Holden2, 3. 1Department of Health Policy
and Management, Johns Hopkins Bloomberg
School of Public Health, Baltimore, MD; 2Brien
Holden Vision Institute, Sydney, NSW, Australia;
3
University of New South Wales, Sydney, NSW,
Australia *CR
4546 — 12:00 An Evaluation of Non-Physician
Educators’ Role In Enhancing Cataract Patient’s
Surgical Knowledge and Satisfaction. Paula
Anne Newman-Casey1, S. Ravilla2, H. Aravind2,
V. Palanichamy2, M. Pillai2, V. Balakrishnan2, A.
L. Robin3. 1Ophthalmology & Visual Sciences,
Kellogg Eye Ctr, Univ of Michigan, Ann Arbor,
MI; 2Ophthalmology and Visual Sciences, Aravind
Eye Care System, Madurai, India; 3Ophthalmology
and Visual Sciences, Johns Hopkins University,
Baltimore, MD *CR
4547 — 12:15 Cohort- and age-specific
effects of annual mass drug administration on
prevalence of trachoma: a longitudinal study in
rural Tanzania. Nakul Shekhawat1, 2, B. E. Munoz1,
H. A. Mkocha3, S. K. West1, 2. 1Dana Center for
Preventative Ophthalmology, Wilmer Eye Institute,
Johns Hopkins, Baltimore, MD; 2Johns Hopkins
Bloomberg School of Public Health, Baltimore,
MD; 3Kongwa Trachoma Project, Kongwa, United
Republic of Tanzania
4554 — 12:15 School-Age Myopic Shift in
Hyperopic Children with Infantile Esotropia and
Peripheral Myopia. Eileen E. Birch1, 2, S. Li1, S. E.
Morale1, R. M. Jost1, V. Subramanian1, D. O. Mutti3.
1
Retina Foundation of the Southwest, Dallas, TX;
2
Ophthalmology, UT Southwestern Medical Center,
Dallas, TX; 3College of Optometry, The Ohio State
University, Columbus, OH
4548 — 12:30 Time-Motion Analysis of Clinical
Nursing Documentation during Implementation
of an Electronic Operating Room Management
System for Ophthalmic Surgery. Sarah ReadBrown1, A. S. Brown1, T. R. Yackel2, D. Choi3,
D. C. Tu1, 4, D. S. Sanders1, M. F. Chiang1, 2.
1
Ophthalmology, Oregon Health & Science
University, Portland, OR; 2Medical Informatics &
Clinical Epidemiology, Oregon Health & Science
University, Portland, OR; 3Public Health &
Preventative Medicine, Oregon Health & Science
University, Portland, OR; 4Portland Veterans
Administration Medical Center, Portland, OR *CR
TCC 303
TCC LL 4/5
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Visual Psychophysics / Physiological Optics
432 Refractive Errors, Myopia II
Moderators: Arthur Bradley and Frank Schaeffel
4549 — 11:00 The impact of Spherical
Aberration, Stiles Crawford Apodization and
Spatial Frequency on wavefront-based and
subjective refractions. Renfeng Xu1, A. Bradley1,
L. N. Thibos1, G. Marin2, M. Hernandez2. 1School
of Optometry, Indiana University, Bloomington, IN;
2
Essilor International, Paris, France *CR
4550 — 11:15 Impact of Primary and
Secondary Spherical Aberration on Predicted
Peripheral Image Quality. Amanda C. Kingston1, 2,
G. Yoon2. 1BME, University of Rochester,
Rochester, NY; 2Flaum Eye Institute, University of
Rochester, Rochester, NY *CR
4551 — 11:30 Peripheral Wavefront
Aberrations of Accommodating Human Eye. Tao
Liu, L. N. Thibos. School of Optometry, Indiana
University, Bloomington, Bloomington, IN *CR
4552 — 11:45 1 Changes in Ocular Biometrics
and Refraction during Near Work in Downward
Gaze over Time. Atanu Ghosh, M. J. Collins, B.
A. Davis, S. A. Read, F. Yi, P. Chatterjee. School
of Optometry and Vision Science, Queensland
University of Technology, Brisbane, QLD, Australia
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Cornea / Cornea
433 Stroma Keratocytes, Development
and Dystrophies
Moderators: Albert S. Jun and Sophie X. Deng
4555 — 11:00 Wnt/b-catenin canonical
signaling in corneal keratocytes regulates
epithelium stratification through repressing
Bmp4/Mapk pathway. Yujin Zhang1, L. Yeh2,
W. W. Kao1, C. Liu1. 1Ophthalmology, University
of Cincinnati School of Med, Cincinnati, OH;
2
Ophthalmology, Chang-Gung Memorial Hospital,
Linko, Taiwan
4556 — 11:15 Peptide Amphiphiles as
Versatile Substrates for Oriented Cell Adhesion
and Proliferation of Human Cornea Stromal
Keratocytes. Ricardo M. Gouveia, V. Castelletto, I.
Hamley, C. J. Connon. School of Chemistry, Food
and Pharmacy, University of Reading, Reading,
United Kingdom
4557 — 11:30 Limbal Biopsy As a Source of
Stem Cells for Autologous Stromal Cell-based
Therapy. Sayan Basu1, 2, M. L. Funderburgh1, J.
L. Funderburgh1. 1Ophthalmology, University of
Pittsburgh School of Medicine, Pittsburgh, PA;
2
Cornea, L V Prasad Eye Institute, Hyderabad, India
4558 — 11:45 Mass Spectrometric - Based
Proteomic Analysis of TGFBI Corneal
Dystrophies. Aarika Menees1, S. Dasari2, A.
Dogan2, S. V. Patel1, K. H. Baratz1, J. D. Theis2, J.
A. Vrana2, D. R. Salomao2, 1. 1Ophthalmology, Mayo
Clinic, Rochester, MN; 2Laboratory Medicine and
Pathology, Mayo Clinic, Rochester, MN *CR
4559 — 12:00 Investigation of Gene Therapy
Using Immortalized Cells Derived from a
Gelatinous Drop-Like Corneal Dystrophy
Patient. Koji Kitazawa1, S. Kawasaki1, K.
Aoi3, 1, K. Shinomiya1, A. Matsuda2, T. Funaki2,
M. Nakatsukasa1, J. Hamuro1, A. Murakami2,
S. Kinoshita1. 1Kyoto Prefectural Univ of Med,
Kyoto, Japan; 2Juntendo University, Tokyo, Japan;
3
Doshisya University, Kyoto, Japan *CR
4553 — 12:00 Effect of Accommodation on
Peripheral Refraction. Jason Shen, F. Spors.
College of Optometry, Western Univ of Hlth
Sciences, Pomona, CA
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
296
Wednesday – Papers/Minisymposium – 4560 – 4574
4560 — 12:15 A Family-based Investigation
of the Role of TCF4 Trinucleotide Repeat
Expansion in Fuchs Endothelial Corneal
Dystrophy (FECD). Keith H. Baratz1, R. A.
Aleff2, Y. Li3, M. L. Butz4, S. G. Gregory5, G. K.
Klintworth6, W. Highsmith4, N. A. Afshari7, E. D.
Wieben2. 1Ophthalmology, Mayo Clinic, Rochester,
MN; 2BIochemistry and Molecular Biology,
Mayo Clinic, Rochester, MN; 3Biostatistics and
BioInformatics, Center for Human Genetics,
Duke University Medical Center, Durham, NC;
4
Laboratory Medicine and Pathology, Mayo Clinic,
Rochester, MN; 5Medicine, Molecular Genetics and
Microbiology, Duke University Medical Center,
Durham, NC; 6Ophthalmology, Duke University
Medical Center, Durham, NC; 7Ophthalmology,
University of California, San Diego, San Diego,
CA *CR
4561 — 12:30 AGBL1 implicated in the
pathogenesis of late-onset FCD and interacts
with TCF4. John D. Gottsch1, S. Vasanth2, N.
Katsanis2, S. Riazuddin1. 1Wilmer Eye Institute,
Johns Hopkins University School of Medicine,
Baltimore, MD; 2Center for Human Disease
Modeling, Duke University Medical Center,
Durham, NC
TCC 304
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Visual Neuroscience
434 Genetics, Development and Aging
Moderators: Rachel O. Wong and Anand Swaroop
4563 — 11:15 Following the Ontogeny of
Retinal Waves: Pan-Retinal Recordings of
Population Dynamics in the Neonatal Mouse.
Evelyne Sernagor1, M. H. Hennig2, A. Maccione3,
M. Gandolfo3, J. Muthmann2, S. J. Eglen4, L.
Berdondini3. 1Institute of Neuroscience, Newcastle
Univ Medical School, Newcastle Upon Tyne,
United Kingdom; 2Institute for Adaptive and Neural
Computation, School of Informatics, University of
Edinburgh, Edinburgh, United Kingdom; 3Dept.
of Neuroscience and Brain Technologies, Italian
Institute of Technology, Genova, Italy; 4Cambridge
Computational Biology Institute, Cambridge
University, Cambridge, United Kingdom *CR
4566 — 12:00 Down-regulation of oxidative
phosphorylation genes and up-regulation
of protein degradation pathway genes are a
hallmark of aging rod photoreceptors in mouse
retina. Tiziana Cogliati1, J. Barb2, N. Gotoh3, M.
Brooks1, L. Gieser1, N. Gupta1, R. Villasmil4, I.
Lee5, P. J. Munson2, A. Swaroop1. 1NNRL, National
Eye Institute - NIH, Bethesda, MD; 2CIT, NIH,
Bethesda, MD; 3Department of Ophthalmology and
Visual Sciences, Kyoto University, Kyoto, Japan;
4
Flow Cytometry Core, National Eye Institute NIH, Bethesda, MD; 5MirCore, Ann Arbor, MI *CR
4567 — 12:15 Synaptic localization but not
specificity is mediated by Down Syndrome Cell
Adhesion Molecule. Peter G. Fuerst1, 2, S. Li1,
D. Schramm1. 1Biological Sciences, University of
Idaho, Moscow, ID; 2UWSOM WWAMI Medical
Education Program, University of Idaho, Moscow,
ID
4568 — 12:30 Developmental changes in
subunit- and pathway-specific expression of
NMDA receptors in direction-selective ganglion
cells. Ben Stafford1, K. Y. Wong1, 2, J. B. Demb3.
1
Ophthalmology and Visual Sciences, University
of Michigan, Ann Arbor, MI; 2Molecular, Cell, and
Developmental Biology, University of Michigan,
Ann Arbor, MI; 3Ophthalmology and Visual
Sciences, Yale University, New Haven, CT
TCC 305
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
435 Neuro-Ophthalmology: Novel
Treatments and Mechanisms of Disease
Moderators: Yaping J. Liao and
Prem S. Subramanian
4569 — 11:00 MTS-AAV Delivery of Human
ND4 in the Mouse Eye. John Guy1, H. Yu1, A.
Mehta2, G. Wang2. 1Bascom Palmer Eye Institute,
University of Miami, Miami, FL; 2Genomics,
Hussman Institute of Human Genomics, Miami, FL
4570 — 11:15 Retinal ganglion cells exhibit
spontaneous hyperactivity and abnormally
sustained light-evoked responses in in a mouse
model of traumatic brain injury. Matthew
Harper1, F. R. Blodi2, 4, M. Shankar2, 4, E.
Hernandez-Merino1, 3, H. Kecova1, 3, L. Dutca1, 3,
R. H. Kardon1, 3, S. F. Stasheff2, 3. 1Center for
the Prevention and Treatment of Visual Loss,
Department of Veterans Affairs, Iowa City, IA;
2
Pediatrics, University of Iowa, Iowa CIty, IA;
3
Ophthalmology and Visual Science, University
of Iowa, Iowa CIty, IA; 4Children’s Hospital,
University of Iowa, Iowa CIty, IA *CR
4571 — 11:30 TrkB Neurotrophin Receptor
Activation with Pharmacophore as Possible
Treatment for Anterior Ischemic Optic
Neuropathy. Yaping J. Liao1, G. Lee1, J. Ma1, T.
Yang2, C. Chakraborty2, B. Barres3, F. Longo2, M.
Shariati1. 1Ophthalmology, Byers Eye Institute
at Stanford, Stanford, CA; 2Neurology, Stanford,
Stanford, CA; 3Neurobiology, Stanford, Stanford,
CA
4572 — 11:45 Genotype-retinal phenotype
correlations in infantile nystagmus. Mervyn G.
Thomas1, V. Sheth1, R. J. McLean1, F. A. Proudlock1,
G. Maconachie1, S. Kohl4, W. Chan2, C. Andrews2,
E. C. Engle2, 3, I. Gottlob1. 1Ophthalmology Group,
University of Leicester, Leicester, United Kingdom;
2
Department of Neurology, Boston Children’s
Hospital, Boston, MA; 3Departments of Neurology,
Ophthalmology, Medicine (Genetics), Harvard
Medical School and Boston Children’s Hospital,
Boston, MA; 4Centre for Ophthalmology, Institute
for Ophthalmic Research, Tuebingen, Germany
4573 — 12:00 Visual outcomes of the
surgical treatment of idiopathic intracranial
hypertension. Prem S. Subramanian1, 2, P.
Fonseca1, N. R. Miller1, 2, D. Rigamonti2. 1Wilmer
Eye Institute, Baltimore, MD; 2Neurosurgery, Johns
Hopkins Unversity Sch of Med, Baltimore, MD
*CR
4574 — 12:15 Treatment of Leber’s hereditary
optic neuropathy (LHON): Results using a
novel quinone, EPI-743. Carlos F. Chicani1, 2,
E. R. Chu2, F. N. Ross-Cisneros2, S. Rockwell2, K.
Murase3, M. Thoolen3, G. Miller3, 4, A. A. Sadun2.
1
Ophthalmology, Federal University of Sao Paulo
- UNIFESP, Sao Paulo, Brazil; 2Ophthalmology,
Doheny Eye Institute - University of Southern
California - Keck School of Medicine, Los Angeles,
CA; 3Edison Pharmaceuticals, Mountain View, CA;
4
Anesthesiology, Stanford University, Stanford, CA
*CR
4564 — 11:30 Dendrites of melanopsin
ganglion cells transiently extend into the outer
retina in early postnatal development. Jordan
M. Renna, D. K. Chellappa, M. E. Estevez, D.
M. Berson. Neuroscience, Brown University,
Providence, RI
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
297
Wednesday Papers/
Minisymposium
11:00 am – 12:45 pm
4562 — 11:00 Distinct Roles Of ActivityDependent And Independent Mechanisms
In Regulating The Bipolar Cell Inputs Onto
Retinal Ganglion Cells. Haruhisa Okawa1, L.
Della Santina1, G. Schwartz2, D. Kerschensteiner3,
F. Rieke2, R. O. Wong1. 1Biological Structure,
University of Washington, Seattle, WA; 2Physiology
and Biophysics, University of Washington,
Seattle, WA; 3Ophthalmology and Visual Sciences,
Washington University, St. Louis, MO
4565 — 11:45 Epigenetic maintenance of
adult cone photoreceptors. Volker Busskamp1, 2,
J. Krol2, K. Farrow2, J. Juettner2, D. Nelidova2, V.
Sothilingam3, M. Garcia Garrido3, M. W. Seeliger3,
W. Filipowicz2, B. Roska2. 1Genetics, Harvard
Medical School, Boston, MA; 2Friedrich Miescher
Institute, Basel, Switzerland; 3Division of Ocular
Neurodegeneration, Institute for Ophthalmic
Research, Tuebingen, Germany *CR
4575 – Wednesday – Papers/Minisymposium
Wednesday Papers/
Minisymposium
11:00 am – 12:45 pm
4575 — 12:30 A Phase I Open Label, Dose
Escalation Trial Of QPI-1007 Delivered By A
Single Intravitreal (IVT) Injection To Subjects
With Low Visual Acuity And Acute NonArteritic Anterior Ischemic Optic Neuropathy
(NAION). Andrew N. Antoszyk1, 2, B. Katz3,
R. Singh4, R. Gurses-Ozden5, S. S. Erlich5, D.
Rothenstein5, N. Sharon5, J. Hodge5, L. A. Levin6, 7,
N. R. Miller8. 1Retina, Charlotte EEN&T Associates,
Charlotte, NC; 2Surgery, Uniformed Services
University of the Health Sciences, Bethesda, MD;
3
Ophthalmology and Visual Sciences, University
of Utah Health Sciences Center, Salt Lake City,
UT; 4Ophthalmology, Cleveland Clinic Foundation,
Cleveland, OH; 5Quark Pharmaceuticals, Inc.,
Fremont, CA; 6Ophthalmology, McGill University,
Montreal, QC, Canada; 7Ophthalmology and Visual
Sciences, University of Wisconsin, Madison, WI;
8
Wilmer Eye Institute, Johns Hopkins University,
Baltimore, MD *CR, f
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
298
Wednesday – Posters – 4576 – 4596
Exhibit Hall A0095-A0113
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Biochemistry/Molecular Biology
436 AMD I, BI
Moderator: Aparna Lakkaraju
4576 — A0095 Autophagy disregulation in
the retina during aging and neurodegeneration.
Enrique J. de la Rosa1, N. Rodriguez-Muela2,
H. Koga3, L. Garcia-Ledo2, P. de la Villa4, A. M.
Cuervo3, P. Boya2. 1Cell & Molecular Medicine,
Centro de Investigaciones Biologicas, Madrid,
Spain; 2Cell & Molecular Biology, Centro de
Investigaciones Biologicas CSIC, Madrid, Spain;
3
Institute for Aging Studies, Albert Einstein College
of Medicine, Bronx, NY; 4Physiology, School of
Medicine, University of Alcala, Alcala de Henares,
Spain *CR
4577 — A0096 High glucose activates
ChREBP-mediated HIF-1α and VEGF
expression in human RPE cells under normoxia.
Min-Lee Chang, C. Chiu, F. Shang, A. Taylor.
HNRCA Tufts University, Boston, MA
4578 — A0097 AMD-associated silent
polymorphisms in HtrA1 ameliorate IGF-1
antagonism. Sarah Melissa P. Jacobo1, 2, M. M.
DeAngelis3, 4, A. Kazlauskas1, 2. 1Ophthalmology,
Harvard Medical School, Boston, MA; 2The
Schepens Eye Research Institute, Boston, MA;
3
Ophthalmology and Visual Sciences, University
of Utah, Salt Lake City, UT; 4John A. Moran Eye
Center, Salt Lake City, UT
4580 — A0099 Stimulation of Semaphorin3E/
PlexinD1 pathway has anti-angiogenic
effect in experimental model of choroidal
neovascularization. Kenji Suda, C. Guo, A. Oishi,
S. Ikeda, N. Yoshimura. Ophthalmology, Kyoto
University, Kyoto, Japan *CR
4581 — A0100 Adiponectin Peptide II
(APNpII) effect on human ARPE-19 cells.
Puran S. Bora, N. S. Bora, V. V. Lyzogubov.
Ophthalmology, Jones Eye Institute-UAMS, Little
Rock, AR
4582 — A0101 Isoform-specific interactions
between human apolipoprotein E and amyloidbeta in the retinal pigment epithelium. Kimberly
A. Toops, J. Xu, A. Lakkaraju. Ophthalmology
and Visual Sciences, University of Wisconsin Madison, Madison, WI
4584 — A0103 Surface plasmon resonance
indicates that complement factor H, C3b and
native properdin bind to carboxyethylpyrroleadducted BSA. Lisa Kuttner-Kondo1, V. P.
Ferreira2, C. Cortes2, S. P. Yadav3, J. G. Hollyfield1.
1
Ophthalmic Research, Cole Eye Institute,
Cleveland Clinic Foundation, Cleveland, OH;
2
Dept. of Medical Microbiology and Immunology,
University of Toledo College of Medicine, Toledo,
OH; 3Molecular Biotechnology Core, Lerner
Research Institute, Cleveland Clinic Foundation,
Cleveland, OH
4585 — A0104 The aging retina: Macula-less
rat and macula-bearing monkey retinae exhibit
common age-related changes in their retinal
proteins. Michael R. Boehm1, 2, S. Mertsch1, H.
Melkonyan1, S. Thanos1. 1Institute for Experimental
Ophthalmology, School of Medicine, WWU
Muenster, Muenster, Germany; 2Current Affiliation:
Department of Ophthalmology, University of
Muenster Medical Center, Muenster, Germany
4591 — A0110 Cd46 -/- Mouse as a Model of
Dry-type Age-related Macular Degeneration.
Valeriy V. Lyzogubov1, X. Wu2, G. Kolar2, P. S.
Bora1, J. P. Atkinson2, N. S. Bora1. 1Ophthalmology,
Jones Eye Institute - UAMS, Little Rock, AR;
2
Department of Medicine, Washington University
School of Medicine, St. Louis, MO
4592 — A0111 Tissue Inhibitor of
Metalloproteinase-3 (TIMP3) Induces
Endothelial Apoptosis via MMP- and CaspaseIndependent Mechanisms. Jian H. Qi, B. AnandApte. Ophthalmic Research-ColeEye Inst, Cole Eye
Institute, Cleveland, OH *CR
4593 — A0112 Localization of
mechanotransduction channels in the trabecular
meshwork of glaucomatous DBA/2J mice. Phi
Ho, V. T. Tran, L. Cabrera, S. K. Bhattacharya.
Bascom Palmer Eye Institute, University of Miami
Miller School of Medicine, Miami, FL
4594 — A0113 CTRP5 over-expression in
RPE cells leads to loss of RPE cell adhesion and
retinal degeneration in wild-type mice. Astra
Dinculescu1, S. Min1, W. Deng1, J. Li1, R. C. Ryals1,
R. M. Stupay1, P. Zhu1, B. Sahu2, R. Ayyagari2, W. W.
Hauswirth1. 1Ophthalmology, University of Florida,
Gainesville, FL; 2Shiely Eye Center, University of
California, San Diego, La Jolla, CA *CR
4586 — A0105 Gene expression profile of
Retinal Pigment Epithelium derived ARPE19 cells under serum starvation. Sanghamitra
Mishra1, K. M. Peterson1, A. E. Berger2, G. J.
Wistow1. 1Section for Molecular Structure and
Functional Genomics, National Eye Institute,
Bethesda, MD; 2JHBMC Lowe Family Genomics
Core, Johns Hopkins University - School of
Medicine, Baltimore, MD
Exhibit Hall A0146-A0178
4587 — A0106 HSPA5 - a possible new
contributing gene in atrophic age-related
macular degeneration. Sumana Chintalapudi,
Y. H. Chan Lau, S. Sahu, M. M. Jablonski.
Ophthalmology, The University of Tennessee
Health Science Center, Memphis, TN *CR
Moderators: Ruth B. Caldwell and Alfred S. Lewin
4588 — A0107 Quercetin Inhibits H2O2
Stimulated PEDF and FGF2 Synthesis in hRPE
Cells. Nandita Anand, P. C. Kothary, M. A. Del
Monte. University of Michigan, Ann Arbor, MI
4589 — A0108 AMD-like phenotypes in
transgenic mice over-expressing BMP4 in RPE.
Danhong Zhu1, J. Xu1, X. Deng1, J. Hsiung1, S.
J. Ryan2, D. R. Hinton1, 2. 1Pathology, University
of Southern California, Los Angeles, CA;
2
ophthalmology, University of Southern California,
Los Angeles, CA *CR
4590 — A0109 Vitamin D Status and
Subretinal Fibrosis in Neovascular Age-Related
Macular Degeneration. Amardeep Singh1, 2,
M. K. Falk1, 2, Y. Subhi1, 2, T. L. Sørensen1, 2.
1
Ophthalmology, Copenhagen University Hospital
Roskilde, Roskilde, Denmark; 2University of
Copenhagen, Copenhagen, Denmark
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Retinal Cell Biology
437 Translational Approaches in AMD
and DR
4595 — A0146 Not age but the rate of aging
drives the pathogenesis of age related macular
degeneration in primates. Peter Gouras1, L. Ivert2,
M. Neuringer3, J. Mattison4. 1Ophthalmology/Eye
Institute, Columbia University, New York, NY;
2
Retina S:t Eriks Eyehospital, Karolinska institute,
Stockholm, Sweden; 3Ophthalmology, Oregon
Health and Science university, Beaverton, OR;
4
Experimental Gerontology, National Institute on
Aging, Baltimore, MD *CR
4596 — A0147 The dual PPAR-α/γ agonist
aleglitazar attenuates retinopathy in
streptozotocin diabetic rats. Raul de la Flor1,
M. B. Wright2, A. P. Adamis3, J. S. Ehrlich3, D. T.
Shima1. 1UCL Institute of Ophthalmology, London,
United Kingdom; 2Pharma Research & Early
Development,DTA Cardiovascular & Metabolism,
F. Hoffmann-La Roche Ltd, Basel, Switzerland;
3
Genentech, South San Francisco, CA *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
299
Wednesday Posters
11:00 am – 12:45 pm
4579 — A0098 Differences in Reactive Oxygen
Species (ROS) Production and Expression of
Genes from the Complement and Inflammatory
Pathways Between H and K Haplogroup
Cybrids. Javier Cáceres del Carpio1, M. Tarek1,
C. A. Ramirez1, P. Falatoonzadeh1, M. Chwa1,
D. Malik1, S. Jazwinski2, M. V. Michael2, B. D.
Kuppermann1, C. M. Kenney1. 1Gavin Herbert Eye
Institute, University of California Irvine, Irvine,
CA; 2Tulane Center for Aging, Tulane University,
New Orleans, LA *CR
4583 — A0102 Effects of the absence of both
complement factor H and apolipoprotein E
on VEGF expression, MMP2/9 activity and
caspase-1. Laura Garcia-Garcia, P. Fernandez, S.
Recalde, M. Moreno-Orduña, V. Fernandez-Garcia,
A. Garcia-Layana. Ophthalmology Experimental
Laboratory, Clinica Universidad de Navarra,
Pamplona, Spain
4597 – 4618 – Wednesday – Posters
4597 — A0148 Overactive Arginase Causes
Mitochondrial Dysfunction and Premature
Endothelial Cell Senescence during Diabetic
Retinopathy. Ruth B. Caldwell1, 3, S. Narayanan1,
M. A. Rojas1, T. Lemtalsi1, Z. Xu1, K. Jittiporn1,
E. Schenhals1, R. W. Caldwell2, D. J. Fulton1, 2.
1
Vascular Biology Center, Georgia Health
Sciences University, Augusta, GA; 2Department
of Pharmacology & Toxicology, Georgia Health
Sciences University, Augusta, GA; 3Charlie
Norwood VA Medical Center, Augusta, GA
4598 — A0149 Potential beneficial effects
of carotenoids on diabetic retinopathy. Renu
A. Kowluru1, Q. Zhong1, J. M. Santos1, M.
ThandampallayamAjje1, D. Putt1, D. L. Gierhart2.
1
Ophthalmology, Wayne State Univ/Kresge Eye
Inst, Detroit, MI; 2Zeavision, L.L.C, Chesterfield,
MO *CR
4599 — A0150 The Impact on Vision and
Regression of Retinal Neovascularization of AntiVEGF Induction in Combination with Quarterly
Anti-VEGF Maintenance or Selective PRP versus
Standard PRP. Victor H. Gonzalez. Valley Retina
Institute PA, Harlingen, TX *CR, f
4600 — A0151 Matrix metalloproteinase-9
regulates angiogenic and vasculogenic factors
in diabetic retina. Ghulam Mohammad, A. Abu
El-Asrar. Ophthalmology, king Saud University,
Riyadh, Saudi Arabia
Wednesday Posters
11:00 am – 12:45 pm
4601 — A0152 Subtoxic Dosage of
Methylglyoxal Stimulated Production of
Urokinase-Type Plasminogen Activator by
Retinal Pigment Epithelial Cells. Anthony
Sclafani1, D. Hu1, 2, T. Vagaggini1, S. A.
McCormick1, 2. 1The NY Eye & Ear Infirmary, New
York, NY; 2New York Medical College, Valhalla,
NY *CR
4602 — A0153 microRNA-30a Antagonism
Inhibits Ras Signaling and Prevents
Neovascularization. Carli M. Wittgrove, P. D.
Westenskow, T. Kurihara, E. Aguilar, S. K. Moreno,
M. Friedlander. Cell Biology, The Scripps Research
Institute, La Jolla, CA
4603 — A0154 Ranibizumab and Bevacizumab
Decrease Macular Ganglion Cell Complex
(GCC) Thickness Measured with FourierDomain Optical Coherence Tomography in AgeRelated Macular Degeneration (AMD). Nalin
J. Mehta1, H. Quiroz-Mercado2, 3, M. J. Sinai6, K.
A. Soules4, A. N. Mehta5, S. Schwartz2, 3. 1Colorado
Retina Center, Lakewood, CO; 2Department of
Ophthalmology, Denver Health Medical Center,
Denver, CO; 3Department of Ophthalmology,
University of Colorado, Denver, CO; 4Optovue Inc.,
Fremont, CA; 5Colorado Academy, Denver, CO;
6
formerly Optovue Inc., Fremont, CA *CR
4604 — A0155 A new mouse model of dry
form AMD. Haoyu Mao, A. S. Lewin, M. Conners.
Molecular Genetics and Microbiology, University
of Florida, Gainesville, FL *CR
4605 — A0156 Serine/Arginine-Rich Protein
Kinase Blockade Attenuates Choroidal
Neovascularization. Zhenyu Dong1, 2, K. Noda1, 2, A.
Kanda1, 2, J. Fukuhara1, 2, R. Ando1, 2, M. Murata1, 2,
W. Saito2, M. Hagiwara3, S. Ishida1, 2. 1Laboratory of
Ocular Cell Biology and Visual Science, Hokkaido
University Graduate School of Medicine, Sapporo,
Japan; 2Department of Ophthalmology, Hokkaido
University Graduate School of Medicine, Sapporo,
Japan; 3Department of Anatomy and Developmental
Biology, Kyoto University Graduate School of
Medicine, Kyoto, Japan *CR
4606 — A0157 Osteopontin (OPN) is Present
in Drusen and Basal Deposits in Human Eyes
with Age-Related Macular Degeneration (AMD).
Amanda Bednar, M. Choudhary, P. Saloupis, A. D.
Proia, G. Malek. Opthamology, Duke University,
Durham, NC
4607 — A0158 The Role of Abnormal Blood
Flow in Age-Related Macular Degeneration.
Luis Alarcon-Martinez1, 2, H. Rieiro1, T. Demirci1,
R. Leal-Campanario1, 3, S. Martinez-Conde1, S. L.
Macknik1. 1Neurobiology, Barrow Neurological
Institute, Phoenix, AZ; 2Ophthalmology,
University of Murcia, Murcia, Spain; 3División
de Neurociencias, Universidad Pablo de Olavide,
Sevilla, Spain
4608 — A0159 RPE, Bruch’s membrane
changes in rabbit eyes and a human eye with
retinal photoxicity. Mehmet Koray Sevinc1, U.
Erdem1, A. Kubar2, E. Oztas3. 1Ophthalmology,
Gülhane Military Medical Faculty, Ankara, Turkey;
2
Microbiology, Gülhane Military Medical Faculty,
Ankara, Turkey; 3Histology, Gülhane Military
Medical Faculty, Ankara, Turkey
4609 — A0160 Inflammatory monocytes
accumulate in atrophic age-related macular
degeneration. Sophie Lavalette1, 2, S. Camelo3, 4,
O. Levy1, 2, W. Raoul1, 2, B. Calippe1, 2, X. P.
Guillonneau1, 2, C. Combadière5, 6, F. Sennlaub1, 2.
1
INSERM,U968, Paris, France; 2UPMC Univ Paris
06, UMR_S 968, Institut de la Vision, Paris, France;
3
INSERM, UMR_S 872, Centre de Recherche des
Cordeliers, Paris, France; 4UPMC Univ Paris 06,
UMR_S 872, Paris, France; 5INSERM UMR_S
945, Laboratoire d’Immunologie Cellulaire, Paris,
France; 6UPMC Univ Paris 06, UMR_S 945, Paris,
France
4610 — A0161 Cell growth inhibtion in HPV 18
positive uveal melanoma cells by E6/E7 siRNA.
Xianqun Fan, R. Jia. Ninth People’s Hospital,
Shanghai Jiaotong University School of Medicine,
Shanghai, China
4611 — A0162 Aflibercept is internalized
by retinal microvascular endothelial cells.
Heidrun L. Deissler, G. E. Lang. Department of
Ophthalmology, University of Ulm, Ulm, Germany
*CR
4612 — A0163 Therapeutic Efficacy of Adipose
Stromal Cells to Protect the Retinal Neurons and
Vasculature in Rat Retinal Ischemia-reperfusion
Injury Model. Chandrika Abburi1, A. J. Cantor1, S.
Caballero5, R. Maturi3, 1, T. S. Kern4, M. B. Grant5,
K. L. March2, G. Rajashekhar1, 2. 1Ophthalmology,
Eugene and Marilyn Glick Eye Institute, Indiana
Univ., Indianapolis, IN; 2Indiana Center for Vascular
Biology & Medicine, Indianapolis, IN; 3Midwest
Eye Institute, Indianapolis, IN; 4Ophthalmology,
Case Western Reserve University, Cleveland, OH;
5
Pharmacology and Therapeutics, University of
Florida, Gainesville, FL *CR
4613 — A0164 Lp-PLA2 is a potential
therapeutic target in diabetic macula edema.
Paul Canning1, J. V. Glenn1, V. Prise1, D. C.
Gale2, A. W. Stitt1, P. S. Adamson3. 1Centre of
Vision & Vascular Science, Queens University
Belfast, Belfast, United Kingdom; 2Ophthalmology
Discovery Performance Unit, GlaxoSmithKline,
King of Prussia, PA; 3Ophthalmology Discovery
Performance Unit, GlaxoSmithKline, Stevenage,
United Kingdom *CR
4614 — A0165 Differential impairment of rod
and cone pathways in streptozotocin-induced
diabetic mice. Ilaria Piano1, A. Caputo2, E.
Novelli1, L. A. Cervetto2, C. M. Gargini2. 1IRCCSG.B. Bietti Foundation for Ophthalmology
Research, Rome, Italy; 2Pharmacy, University of
Pisa, Pisa, Italy
4615 — A0166 Comparative Ocular Tissue
Distribution Kinetics of the Visual Cycle
Modulator (VCM) Emixustat-HCl in Rats,
Beagle Dogs, and Cynomolgus Monkeys.
Terry Podoll1, S. Al-Fayoumi1, E. Prescott2, J. W.
Chandler1, R. Kubota1. 1Acucela Inc, Seattle, WA;
2
Covance Laboratories Inc, Madison, WI *CR
4616 — A0167 Systemic erythropoietin and its
role in diabetic retinopathy. Sofija Davidovic1, S.
Latinovic2. 1Department for vitreoretinal diseases,
University Eye Clinic Clinical Center Vojvodina,
Novi Sad, Serbia; 2VIDAR ORASIS- Swiss, Private
Eye hospital, Novi Sad, Serbia
4617 — A0168 Chemical Screens in
Zebrafish Identify Novel Inhibitors of Retinal
Neovascularisation in Mouse. Breandan N.
Kennedy1, Y. Alvarez1, M. Tosetto2, C. Kilty1, T.
Sasore1, C. M. McVicar3, A. W. Stitt3, J. O’Sullivan4,
A. L. Reynolds1. 1UCD School of Biomolecular
and Biomedical Science & UCD Conway Institute,
University College Dublin, Dublin, Ireland; 2St.
Vincent’s University Hospital, University College
Dublin, Dublin, Ireland; 3Centre for Vision and
Vascular Science, Queen’s University, Belfast,
United Kingdom; 4Department of Surgery, Trinity
College Dublin, Dublin, Ireland *CR
4618 — A0169 Evaluation of Antiangiogenic
Effect of Sintetic Small Fragments of PEDF.
Andrea R. Carvalho, J. Badal, M. A. Zapata, A.
Salas Torras, L. N. Distefano, J. Garcia-Arumi.
Ophthalmology, Inst de Recerca Hosp Vall
d’Hebron, Barcelona, Spain
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
300
Wednesday – Posters – 4619 – 4641
4619 — A0170 A novel Erythropoietin-derived
peptide regulates Endothelial Progenitor Cell
(EPC) mediated retinal vasorepair. Olivia E.
O’Leary1, E. Reid1, C. M. McVicar1, M. Brines2, A.
Cerami2, R. J. Medina1, D. P. Brazil1, A. W. Stitt1.
1
Centre for Vision and Vascular Science, Queen’s
University Belfast, Belfast, United Kingdom;
2
Warren Pharmaceuticals, Ossining, NY *CR
4620 — A0171 Effect of HMG-CoA reductase
inhibitor(statins) on the expression of catalase
in human retinal pigment epithelial cells. Min
Gu Kang, S. Lee, N. Kim, H. Chin. Department
of Ophthalmology and Inha Vision Science
Laboratory, Inha University School of Medicine,
Incheon, Republic of Korea
4621 — A0172 Resveratrol suppresses the
VEGF expression by inhibition of the CXCR4
Expression in ARPE-19 cells. Inyoung Chung1, H.
Seong2, S. Kang2, J. Park1, S. Seo1. 1Ophthalmology,
School of Medicine, Institute of Health Sciences,
Gyeongsang National University, Jinju-si,
Republic of Korea; 2Anatomy and Neurobiology,
School of Medicine, Institute of Health Sciences,
Medical Research Center for Neural Dysfunction,
Gyeongsang National University, Jinju-si, Republic
of Korea
4622 — A0173 Antiangiogenic Effect of
Quercetin on Laser-Induced Choroidal
Neovascularization in Mice. Junichi Fukuhara1, 2,
K. Noda1, 2, S. Takashina1, 2, Y. Dong1, 2, S.
Kinoshita1, 2, Z. Dong1, 2, R. Ando1, 2, A. Kanda1, 2,
S. Ishida1, 2. 1Laboratory of Ocular Cell Biology
and Visual Science, Hokkaido University Graduate
School of Medicine, Sapporo, Japan; 2Department
of Ophthalmology, Hokkaido University Graduate
School of Medicine, Sapporo, Japan
4624 — A0175 Inhibition of Laser-induced
Choroidal Neovascularization by Macrolactin
Compounds. Sang Jin Kim1, J. Kim1, D. Kim2.
1
Ophthalmology, Samsung Medical Center,
Sungkyunkwan University School of Medicine,
Seoul, Republic of Korea; 2Research and
Development Center, Daewoo Pharm. Co. Ltd.,
Busan, Republic of Korea *CR
4625 — A0176 Inhibition of choroidal
neovascularization by neutralizing PDGF with
a recombinant fusion protein of PDGFR β
domain. Yiwen Li1, W. Tao2, V. Ling2, A. Nystuen2,
S. A. Elliott2, P. Stabila2, R. Wen1. 1Bascom Palmer
Eye Institute, University of Miami, Miami, FL;
2
Neurotech USA, Lincoln, RI *CR
4626 — A0177 One-year Results of Intravitreal
Ranibizumab Combined with Reduced-Fluence
Photodynamic Therapy for Polypoidal Choroidal
Vasculopathy. Daisuke Yamanouchi, M. Sakurai,
T. Baba, M. Kitahashi, H. Yokouchi, M. KubotaTaniai, S. Yamamoto. Chiba univercity, Chiba, Japan
Exhibit Hall B0092-B0137
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Physiology/Pharmacology / Retinal Cell Biology
438 Retinal Flow and VEGF
Moderators: Michele Reibaldi and Tonia S. Rex
4628 — B0092 Subfoveal Choroidal blood
flow in senescence. John V. Lovasik, H. Kergoat,
M. Parent. School of Optometry, University of
Montreal, Montreal, QC, Canada
4629 — B0093 Time-dependent intracellular
pattern of Bevacizumab in RPE cells. Shereen
Hassan M. Aboul Naga1, 2, M. Dithmer1, J. Roider1,
A. K. Klettner1. 1Ophthalmology, University of
Kiel, University Medical Centre, Kiel, Germany;
2
Ophthalmology, Kasr Al Aini, Cairo University
Hospitals, Cairo, Egypt *CR
4630 — B0094 Antagonism of PDGFRβ
Inhibits Pericyte Recruitment in a Mouse Model
of Corneal Neovascularization. Amy Jensen1, R.
Cepeda1, M. Maker1, C. E. Bigelow1, J. Ghosh1,
G. Li1, P. A. D’Amore2, G. Spohn1, B. D. Jaffee1, S.
Azarian1. 1Ophthalmology, Novartis, Cambridge,
MA; 2Ophthalmology, Schepens Eye Research
Institute, Boston, MA *CR
4631 — B0095 Dynamic retinal venous
oscillations are changed in diabetes mellitus
type 1. Konstantin E. Kotliar1, 2, I. M. Lanzl2, T.
Siegmund4, A. Schmidt-Trucksaess5, 3. 1Biomedical
Engineering, Aachen University of Applied
Sciences, Juelich, Germany; 2Ophthalmology,
Munich University of Technology, Munich,
Germany; 3Preventive Sports Medicine, Munich
University of Technology, Munich, Germany;
4
Endocrinology and Diabetes, Bogenhausen
Hospital, Munich, Germany; 5Division of Sports
Medicine, University of Basel, Basel, Switzerland
*CR
4632 — B0096 Parameters related to Choroidal
thickness. Yasuki Ito1, K. Oiwa1, E. Iwata1, A.
Takahashi1, T. Yasuma1, K. Kawano1, N. Hamajima2,
H. Terasaki1. 1Ophthalmology, Nagoya University
Graduate School of Medicine, Nagoya, Japan;
2
Department of Preventive Medicine, Nagoya
University Graduate School of Medicine, Nagoya,
Japan
4633 — B0097 Blockade of PGF/VEGFR1
signaling significantly prevents BRB breakdown,
apoptosis and inflammation in diabetic
retinopathy. Hu Huang, D. Johnson, D. Kim, G. A.
Lutty. Ophthalmology, Johns Hopkins Wilmer Eye
Inst, Baltimore, MD
4634 — B0098 Computational Model of
Oxygen Transport in Retina and Optic Nerve.
David Bragason1, E. Stefánsson1, 2. 1Ophthalmology,
Landspitali University Hospital, Reykjavik, Iceland;
2
Medicine, University of Iceland, Reykjavik,
Iceland *CR
4635 — B0099 Increased Retinal Vascular
Tortuosity in Obstructive Sleep Apnea. Amir
Mohsenin1, V. Mohsenin2, R. A. Adelman1.
1
Department of Ophthalmology, Yale University
School of Med, New Haven, CT; 2Yale Center
for Sleep Medicine, Yale University School of
Medicine, New Haven, CT
4636 — B0100 Oxygen saturation in
retinal hemorrhages. Olafur Palsson1, 2, S. H.
Hardarson1, 2, T. S. Eliasdottir2, E. Stefánsson1, 2.
1
Department of Ophthalmology, Landspítali
University Hospital, Reykjavik, Iceland; 2University
of Iceland, Reykjavik, Iceland *CR
4637 — B0101 Assessment of Total Retinal
Blood Flow under Systemic Hypercapnia
and Hypocapnia. Ayda M. Shahidi1, S. R.
Patel1, J. G. Flanagan1, 3, O. Tan2, D. Huang2, C.
Hudson1, 3. 1Ophthalmology & Vision Science,
University Health Network, Toronto, ON, Canada;
2
Ophthalmology, Oregon Health and Science
University, Portland, OR; 3Optometry & Vision
Science, University of Waterloo, Waterloo, ON,
Canada *CR
4638 — B0102 One-year results of
Central Retinal Sensitivity in eyes treated
with Pegaptanib for Proliferative Diabetic
Retinopathy with extended dosing. Blanca C.
Flores, V. H. Gonzalez, R. Diaz-Rohena. Valley
Retina Institute, McAllen, TX *CR, f
4639 — B0103 Persistent hyaloid vessels
counteract insufficient retinal perfusion in the
mouse eye. Christina Seide, M. Garcia Garrido,
V. Sothilingam, N. Tanimoto, S. C. Beck, M. W.
Seeliger. Div of Ocular Neurodegeneration, Ctr for
Ophthal Inst for Ophth Rsrch, Tuebingen, Germany
4640 — B0104 Retinal Vessel Diameter at
High Altitude. Gabriel Willmann1, A. Schatz1, M.
Fischer1, 3, K. Schommer2, E. Zrenner1, K. BartzSchmidt1, F. Gekeler1. 1Centre for Ophthalmology,
University of Tübingen, Tübingen, Germany;
2
Department of Sports Medicine, University
Hospital Heidelberg, Heidelberg, Germany;
3
Nuffield Laboratory of Ophthalmology, University
of Oxford, Oxford, United Kingdom *CR
4641 — B0105 Retinal and Cerebral
Oxygenation Response to Graded Hypoxia.
Sunni R. Patel1, C. Hudson2, 3, A. M. Shahidi1,
S. Kulasekara2, J. Fisher4, J. G. Flanagan2, 3, W.
Mutch5. 1Ophthalmology and Vision Sciences,
Toronto Western Hospital, Toronto, ON, Canada;
2
Department of Ophthalmology and Vision
Science, University of Toronto, Toronto, ON,
Canada; 3School of Optometry and Vision Science,
University of Waterloo, Toronto, ON, Canada;
4
School of Physiology, University of Toronto,
Toronto, ON, Canada; 5Perioperative Medicine
and Anaesthesiology, University of Manitoba,
Winnepeg, MB, Canada *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
301
Wednesday Posters
11:00 am – 12:45 pm
4623 — A0174 Genistein Suppresses LaserInduced Choroidal Neovascularization in Mice.
Satoshi Kinoshita1, 2, K. Noda1, 2, S. Takashina1, 2,
Y. Dong1, 2, J. Fukuhara1, 2, Z. Dong1, 2, R. Ando1, 2,
A. Kanda1, 2, S. Ishida1, 2. 1Laboratory of Ocular
Cell Biology and Visual Science, Hokkaido
University Graduate School of Medicine, Sapporo,
Japan; 2Department of Ophthalmology, Hokkaido
University Graduate School of Medicine, Sapporo,
Japan
4627 — A0178 NIPAAm Based Cell Delivery
Scaffolds for Posterior Segment Therapeutics.
Ben Muirhead1, S. D. Fitzpatrick1, K. GregoryEvans2, M. Bhatia1, H. Sheardown1. 1Biomedical
Engineering, McMaster University, Elmira, ON,
Canada; 2Ophthalmology and Visual Sciences,
University of British Columbia, Vancouver, BC,
Canada *CR
4642 – 4666 – Wednesday – Posters
4642 — B0106 3-D Computer-Automated
Threshold Amsler Grid to Quantify Retinal
Deficits Before and After Standard Treatment of
Wet Age-related Macular Degeneration. Kristie
Lin1, W. Fink2, 3, S. Kamjoo1, M. Davis1, T. Chang1.
1
Retina Institute of California, Arcadia, CA;
2
Physics, Mathematics and Astronomy, California
Institute of Technology, Pasadena, CA; 3Biomedical
Engineering, University of Arizona, Tuscon, AZ
*CR, f
4643 — B0107 Treatment of retinal capillary
hemangioblastoma using inhibitors of the HIF
pathway. Mridul Mukherji, D. Vavilala, P. Swami,
V. Ponnaluri. Pharmacy - Pharmaceutical Sci, Univ
of Missouri - Kansas City, Kansas City, MO
4644 — B0108 Short-term Effects of Cocoa
on Retinal Reactivity in Individuals with
Prediabetes and Type 2 Diabetes. Mary E. Lott1,
A. Johns1, J. Oman1, J. E. Slocomb2, M. Herr1,
R. A. Gabbay3, D. A. Quillen4, K. Bettermann2.
1
Heart and Vascular Institute, Penn State Milton S
Hershey Med Ctr, Hershey, PA; 2Neurology, Penn
State Milton S Hershey Med Ctr, Hershey, PA;
3
Endocrinology, Penn State Milton S Hershey Med
Ctr, Hershey, PA; 4Opthalmology, Penn State Milton
S Hershey Med Ctr, Hershey, PA
4645 — B0109 Altered Vascular
Microenvironment by Bevacizumab in
Diabetic Fibrovascular Membrane. Shintaro
Nakao1, K. Ishikawa1, S. Yoshida1, R. Kohno1, M.
Miyazaki1, H. Enaida1, T. Kono2, T. Ishibashi1.
1
Ophthalmology, Kyushu University, Fukuoka,
Japan; 2Ophthalmology, Fukuoka University,
Fukuoka, Japan
Wednesday Posters
11:00 am – 12:45 pm
4646 — B0110 Retinal Oxygenation During
Intravitreal Treatment for Central Retinal Vein
Occlusion. Sindri Traustason, M. D. de La Cour,
M. Larsen. Dept of Ophthalmology,Glostrup Univ
Hosp, Copenhagen University, Glostrup, Denmark
*CR, f
4647 — B0111 Rationale for Bimonthly
Ranibizumab and Quarterly Aflibercept. A Drug
and Disease Assessment Model in Wet Agerelated Macular Degeneration. Daniele Veritti1,
G. Gorni2, L. Perissin3, P. Lanzetta1. 1Department of
Ophthalmology, University of Udine, Udine, Italy;
2
Department of Mathematics and Computer Science,
University of Udine, Udine, Italy; 3Department of
Biomedical Sciences and Technologies, University
of Udine, Udine, Italy *CR
4650 — B0114 Perifoveal Microvasculature
in Human Eyes with Vascular Comorbidities.
Geoffrey Chan1, 2, C. Bala1, 2, P. Yu1, 2, W. Morgan1, I.
L. McAllister1, S. J. Cringle1, 2, Y. Dao-Yi1, 2. 1Centre
for Ophthalmology and Visual Science, Perth, WA,
Australia; 2Australian Research Council Centre
of Excellence in Vision Science, Canberra, ACT,
Australia *CR
4651 — B0115 Flavonoid-rich dark chocolate
improves endothelial function in retinal
vessels. Naim Terai, A. Gedenk, E. Spoerl, R.
P. Stodtmeister. Ophthalmology, University of
Dresden, Dresden, Germany *CR
4652 — B0116 Inhibition of retinal
neovascularization by luteolin via suppression
of VEGF expression and VEGFR signaling
pathway. Sung Wook Park1, 2, C. Cho1, H. Jun1,
N. Ryu3, J. Kim1, Y. S. Yu1, J. Kim3, J. Kim1, 2.
1
FARB, Department of Ophthalmology, Seoul
National University Hospital, Seoul, Republic
of Korea; 2Biomedical Sciences, Seoul National
University College of Medicine, Seoul, Republic of
Korea; 3Diabetic Complications Research Center,
Division of Traditional Korean Medicine Integrated
Research, Korea Institute of Oriental Medicine,
Daejeon, Republic of Korea
4653 — B0117 Plasma VEGF-levels are
variable in patients with persistent renal
dysfunction and diabetes: possible implications
and risks for ophthalmic anti-VEGF therapy.
Markus van der Giet, M. Schuchardt, N. Pruefer,
J. Pruefer. Med. Klinik - SP Nephrology, Charite Universitätsmedizin Berlin, Berlin, Germany *CR
4654 — B0118 Pathological retinal
neovascularization is exacerbated by selective
pharmacological blockade of VEGFR2, but
ameliorated by combination with Placental
Growth Factor (PlGF) inhibition in the Oxygen
induced Retinopathy (OIR) model in mice.
Eunice Cheung, I. B. Lobov, G. D. Yancopoulos,
S. J. Wiegand. Ophthalmology, Regeneron
Pharmaceuticals, Inc., Tarrytown, NY *CR
4655 — B0119 Treatment of proliferative
idiopathic macular telangiectasia Type 2 with
intravitreal bevacizumab. Ranjit Sandhu, R. D.
Hamilton. Medical Retina, Moorfields Eye Hospital,
London, United Kingdom *CR
4648 — B0112 Retinal Vein Occlusions in
Young Patients: Visual Outcomes and Associated
Systemic Risk Factors. Noureen Khan1, 2, M.
M. Lai1, 2. 1Dept. of Ophthalmology, Georgetown
University/Washington Hospital Center,
Washington, DC; 2The Retina Group of Washington,
Chevy Chase, MD
4656 — B0120 Computational model of blood
flow through the choriocapillaris highlights
marked heterogeneity of blood flow. Moussa A.
Zouache1, 2, P. J. Luthert1, 2, I. Eames3. 1Institute
of Ophthalmology, University College London,
London, United Kingdom; 2NIHR Biomedical
Research Centre in Ophthalmology, London, United
Kingdom; 3Department of Mechanical Engineering,
University College London, London, United
Kingdom
4649 — B0113 Effects of Prostacyclin on
Isolated Porcine Retinal Arterioles: Cross-Talk
between Nitric Oxide and Prostacyclin. Shinji
Ono, T. Nagaoka, T. Omae, T. Kamiya, A. Yoshida.
Ophthalmology, Asahikawa Med University,
Asahikawa, Japan *CR
4657 — B0121 Periocular injection of a broad
spectrum antiangiogenic therapy regresses
choroidal neovascularization. Ofra Benny, Z.
Chi, L. Bazinet, R. J. D’Amato. Boston Children’s
Hospital, Harvard Medical School, Boston, MA
*CR
4658 — B0122 Efficacy and safety of
subconjunctival bevacizumab for recurrent
pterygium. Larissa S. Stival1, A. M. Lago1, M.
N. Figueiredo1, R. G. Bittar2, M. L. Machado1, J.
J. Nassaralla2. 1Cornea and Refractive Surgery,
Instituto de Olhos de Goiania, Goiania, Brazil;
2
Retina and Vitreous, IOG, Goiania, Brazil f
4659 — B0123 A Treat and Extend Regimen
Using Anti-VEGF Therapies for Central Retinal
Vein Occlusion. Christopher J. Brady, R. Alshareef,
A. J. Witkin, C. D. Regillo. Wills Eye Institute,
Jefferson Univ School of Medicine, Philadelphia,
PA *CR
4660 — B0124 In vitro studies on the
antiangiogenic effects of Pigment Epithelium
Derived Factor and Somatostatin. Anna Salas
Torras, A. R. Carvalho, I. Abasolo, M. A. Zapata,
L. N. Distefano, S. Schwartz, J. Garcia-Arumi.
Ophthalmology, Vall d’Hebron Research Inst,
Barcelona, Spain
4661 — B0125 Our experience with Sequential
treatment of macular oedema from retinal
vascular occlusions with anti-VEGF agents and
Ozurdex. Evangelia Papavasileiou, A. Grixti, V.
Kumar, S. Prasad. Eye Treatment Centre, Arrowe
Park University Hospital, London, United Kingdom
*CR
4662 — B0126 Short Term Ocular Response
of retinal blood flow to intravitreal injection
of bevacizumab (Avastin○R) treatment in eyes
with central retinal vein occlusion. Seung W. Lee.
Ophthalmology, Dongguk Unv, Gyeongju Hosp,
Gyeongju, Republic of Korea
4663 — B0127 The Effect of Diluted Sterile
Penetration Enhancer Solution in Nebulized Mist
and Liquid Drop Forms on Ocular Circulation
in Patients with Diabetic Retinopathy. Lina
Krepste1, A. Harris2, I. Januleviciene1, V. J.
Balciuniene1, L. Siaudvytyte1, R. Barsauskaite1,
A. L. Gerber2, B. Siesky2. 1Eye Clinic, Lithuanian
University of Health Sciences, Kaunas, Lithuania;
2
Eugene and Marilyn Glick Eye Institute, Indiana
University School of Medicine, Indianapolis, IN
*CR, f
4664 — B0128 Measurement of Retinal Blood
Flow Velocity Using a Newly Developed Doppler
Fourier-Domain Optical Coherence Tomography
Instruments in Humans. Akitoshi Yoshida, T.
Nagaoka, T. Tani, E. Sato, T. Yoshioka, K. Sogawa,
S. Nakabayashi. Ophthalmology, Asahikawa
Medical University, Asahikawa, Japan
4665 — B0129 Mechanisms of retinal venous
pulsation inferred from diameter waveforms
analysis. Fabrice Moret1, W. Lagreze2, C. M.
Poloschek1, 2, M. Bach1. 1Sect. Visual Function and
Electrophys, Eye Hospital, University of Freiburg,
Freiburg, Germany; 2Sect. Neuroophthalmology,
Eye Hospital, University of Freiburg, Freiburg,
Germany *CR
4666 — B0130 Effect of Nitric Oxide on
Increased Retinal Blood Flow in Response to
Flicker Stimuli in Cats. Takafumi Yoshioka, T.
Nagaoka, A. Yoshida. Ophthalmology, Asahikawa
Medical University, Asahikawa, Japan
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
302
Wednesday – Posters – 4667 – 4686
4667 — B0131 Measurement Of Retinal
Blood Flow and Retinal Oxygen Tension During
Acute Decreasing Systemic Blood Pressure In
Cats. Tomofumi Tani, T. Nagaoka, T. Yoshioka,
A. Yoshida. Ophthalmology, Asahikawa Medical
University, Asahikawa, Japan
4668 — B0132 Measurement of Retinal
Blood Flow Using a Newly Developed Doppler
Fourier-Domain Optical Coherence Tomography
Instruments in Cats. Taiji Nagaoka, T. Tani, E.
Sato, T. Yoshioka, K. Sogawa, S. Nakabayashi,
A. Yoshida. Ophthalmology, Asahikawa Medical
University, Asahikawa, Japan
4669 — B0133 Development of a prototype of
laser Doppler flowmeter for the measurement
of blood flow of retinal vessels and optic nerve
head tissue in small animals (rats). Marielle
Mentek1, C. Chiquet3, 1, F. Truffer2, M. Bernabei2, B.
Mottet3, J. Romanet3, D. Godin-Ribuot1, M. Geiser2.
1
INSERM U1042, Grenoble, France; 2Institute
of system engineering, University of Applied
Sciences of Western Switzerland, Sion, Switzerland;
3
Ophthalmology department, CHU Grenoble,
Joseph Fourier University, Grenoble, France
4670 — B0134 Retinal blood velocity
significantly decreased in rhegmatogenous
retinal detachment and recovered after surgical
treatment in both artery and vein. Hirofumi
Kinoshita, K. Suzuma, M. Uematsu, R. Ueki, T.
Kitaoka. Nagasaki Univ School of Medicine,
Nagasaki, Japan
4671 — B0135 Ocular rigidity as estimated
based on measurement of pulse amplitude using
pneumotonometry and fundus pulse is dependent
on intraocular pressure. Anton B. Hommer1, 2,
G. Garhofer2, L. Schmetterer2. 1Krankenhaus
Hera Vienna, Vienna, Austria; 2Dep.of. Clinical
Pharmacology, University Clinic, Vienna, Austria
*CR
4673 — B0137 Ocular Pulse Amplitude
Waveform Reflects Ventricular Bigeminy
and Aortic Insufficiency. Jean B. Kassem1, 2, S.
E. Katz1, 2, C. J. Roberts2, 3, A. M. Mahmoud2, 3,
R. H. Small4, 3, S. V. Raman5, 3. 1Neuro-OrbitOculoplastics, Havener Eye Institute, Columbus,
OH; 2Ophthalmology, The Ohio State University,
Columbus, OH; 3Biomedical Engineering, The Ohio
State University, Columbus, OH; 4Anesthesiology,
The Ohio State University, Columbus, OH;
5
Cardiovascular Medicine, The Ohio State
University, Columbus, OH *CR
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Nanotechnology and Regenerative Medicine
439 Ocular Nanoimaging,
Nanobiosensors and Nanodiagnostics
Moderators: Yolanda Diebold and Stephen H. Tsang
4674 — B0243 Functional rescue for a full
year after gene therapy in a pre-clinical model
of retinitis pigmentosa. Katherine J. Wert1, 2, R. J.
Davis1, J. Sancho-Pelluz1, C. Lin1, S. H. Tsang1, 3.
1
Ophthalmology, Columbia University, New York,
NY; 2Institute of Human Nutrition, Columbia
University, New York, NY; 3Pathology & Cell
Biology, Columbia University, New York, NY
4675 — B0244 The effect of nano-structural
hydroxyapatite on the biocompatibity of artificial
cornea skirt material in vitro and in vivo. Ying
Dong1, 2, L. Wang2, J. Yang3, Y. Huang2, F. Cui3.
1
Department of Ophthalmology, First Hospital
Affiliated to Chinese PLA General Hospital,
Beijing, China; 2Department of Ophthalmology,
Chinese PLA General Hospital, Beijing, China;
3
Department of Material Science and Engineering,
Tsinghua University, Beijing, China
4676 — B0245 Formulation of a Biocompatible
Photopolymerizable Gel to Prevent the
Oxiative Damage of the Crystalline Lens.
Tongalp H. Tezel1, 2, Q. Zeng1, M. G. O’Toole3, A.
S. Gobin3. 1Ophthal & Vis Sciences, University
of Louisville, Louisville, KY; 2Anatomy and
Neurobiology, University of Louisville, Louisville,
KY; 3Bioengineering, University of Louisville,
Louisville, KY *CR
4677 — B0246 Efficacy of a novel
bioengineered corneal stroma fabricated by
a new biocompatible cross linker in corneal
stromal disease model. Takeshi Soma1, M.
Matsusaki2, M. Matsumoto2, H. Ajiro2, M.
Tsujikawa1, R. Hayashi1, Y. Oie1, M. Akashi2, K.
Nishida1. 1Department of Ophthalmology, Osaka
University Graduate School of Medicine, Suita,
Japan; 2Department of Applied Chemistry, Osaka
University Graduate School of Graduate School of
Engineering, Suita, Japan *CR
4678 — B0247 Feasibility of 2nd Generation
STS Retinal Prosthesis with 49 Channel
Electrode Array in Dogs. Takashi Fujikado1, 2, M.
Kamei2, H. Sakaguchi2, H. Kanda1, T. Morimoto1, 2,
K. Nishida2, H. Kishima3, T. Maruo3, K. Osawa4,
M. Ozawa4. 1Applied Visual Science, Osaka
University, Suita, Japan; 2Ophthalmology, Osaka
University, Suita, Japan; 3Neurosurgery, Osaka
University, Suita, Japan; 4Vision Institute, Nidek
Co., Gamagori, Japan *CR
4679 — B0248 Air transport system of oral
mucosal tissue and cell sheets for clinical
trial. Yoshinori Oie1, S. Andojo1, N. Konno1, H.
Takayanagi2, T. Nozaki3, S. Takeda3, T. Soma1, M.
Tsujikawa1, K. Nishida1. 1Ophthalmology, Osaka
University, Suita, Japan; 2Translational Research
Center, Tohoku Univeristy, Sendai, Japan; 3Central
Research Laboratory, Hitachi, Tokyo, Japan *CR
4680 — B0249 Fullerenol Protects RPE cells
from Oxidative-stress Induced Premature
Senescence via Activation of SIRT1. Guo-Tong
Xu1, 2, C. Zhuge1, J. Xu2, 3, J. Zhang2, 3, G. Xu4,
L. Chen2, 3, X. Liu2, 3, H. Xu2, 3, L. Lu2, 3, W. Li5.
1
Laboratory of Clinical Visual Science, Institute of
Health Sciences, Shanghai Institutes for Biological
Sciences, Chinese Academy of Sciences, Shanghai,
China; 2Ophthal, Regenerativie Med, Tongji Univ
School of Medicine, Shanghai, China; 3Department
of Regenerative Medicine and Stem Cell Research
Center, Tongji University School of Medicine,
Shanghai, China; 4Department of Ophthalmology,
Second Affiliated Hospital, Suzhou University,
Suzhou, China; 5Department of Ophthalmology,
Drexel University College of Medicine,
Philadelphia, PA
4681 — B0250 Reconstruction of Conjunctival
Epithelium with Goblet Cells by Collagen
Vitrigel. Huifang Zhou1, 2, Q. Guo1, M. Grant3, J.
Elisseeff1. 1Translational Tissue Engineering Center,
Wilmer Eye Institute and Biomedical Engineering,
Baltimore, MD; 2Ophthalmology, Shanghai
Ninth People’s Hospital, Shanghai Jiaotong
University School of Medicine, Shanghai, China;
3
Oculoplastics Division, Ocular and Orbital Trauma
Center, Wilmer Eye Institute, Johns Hopkins School
of Medicine, Baltimore, MD *CR
4682 — B0251 Overall visual performance is
well described by three independent measures
in Argus® II subjects. Thomas Z. Lauritzen1, A.
Das1, 2, J. D. Dorn1, R. J. Greenberg1. 1Second Sight
Med Products, Inc, Sylmar, CA; 2Dept. of Physics,
USC, Los Angeles, CA *CR, f
4683 — B0252 Excimer Ablation of CollagenBased Corneal Substitutes. Silvia Odorcic1, C.
Noel1, D. Mitra1, D. Priest1, S. Taylor1, M. Griffith2,
R. Munger1, W. Jackson1. 1The Ottawa Hospital,
Ottawa, ON, Canada; 2Linköping University,
Linköping, Sweden *CR
4684 — B0253 Human retinal progenitor cells
as a tool for retinal repair: establishing cell lines
for clinical study. Petr Y. Baranov1, G. Brooke2,
S. Patel2, M. J. Young1, J. Sinden2. 1Schepens Eye
Research Institute, Boston, MA; 2ReNeuron Ltd.,
Guildford, United Kingdom *CR
4685 — B0254 Hybrid vitronectin-mimicking
polycaprolactone scaffolds and human retinal
progenitor cell composites. Elodie Lawley1, 2, P. Y.
Baranov1, M. J. Young1. 1Opthamology, Schepens
Eye Research Institute, Massachusetts Eye and Ear,
an affiliate of Harvard Medical School, Boston,
MA; 2Exeter Medical School, Exeter, United
Kingdom *CR
4686 — B0255 Stem Cell and Encapsulated
Drug Delivery to the Inner Retina using a Fibrin
Polymer Spray System. Hari Jayaram1, 2, M. F.
Jones2, R. M. Day3, P. B. Cottrill2, K. Eastlake2, S.
Becker2, G. Limb2. 1NIHR Biomedical Research
Centre for Ophthalmology, UCL Institute of
Ophthalmology & Moorfields Eye Hospital NHS
Foundation Trust, London, United Kingdom;
2
Ocular Biology & Therapeutics, UCL Insitute
of Ophthalmology, London, United Kingdom;
3
Applied Biomedical Engineering, University
College London, London, United Kingdom *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
303
Wednesday Posters
11:00 am – 12:45 pm
4672 — B0136 Sphingosine 1-phosphate
elicits constriction of isolated porcine retinal
arterioles. Takayuki Kamiya, T. Nagaoka, T. Omae,
S. Ono, A. Yoshida. Asahikawa Medical University,
Asahikawa, Japan *CR
Exhibit Hall B0243-B0273
4687 – 4709 – Wednesday – Posters
4687 — B0256 A synthetic carrier for cultured
corneal endothelium implantation. Mark
Daniell1, K. D. Brown1, B. Ozcelik4, P. McKelvie3,
H. Zhang1, K. Abberton2. 1CERA, Melbourne, VIC,
Australia; 2The O’Brien Institute, Fitzroy, VIC,
Australia; 3Anatomical Pathology, St. Vincent’s
Hospital, Melborne, VIC, Australia; 4Chemical
and Biomolecular Engineering, The University of
Melbourne, Parkville, VIC, Australia
4688 — B0257 Vision Restoration in Mouse
Models of RP using Light-Gated G-Protein
Coupled Receptors. Benjamin Gaub, M. Berry,
J. Levitz, J. G. Flannery, E. Isacoff. UC Berkeley,
Berkeley, CA
4689 — B0258 Connective Tissue Growth
Factor Protein Expression by Müller Cells is
Bipartite as a Function of Substrate Stiffness.
William J. Foster1, 2, J. T. Davis2. 1Ophthalmology,
Weill-Cornell Med Coll, Houston, TX; 2Physics,
The University of Houston, Houston, TX
Wednesday Posters
11:00 am – 12:45 pm
4690 — B0259 Corneal Stromal Bioequivalents
Secreted on Patterned Silk Substrata by Corneal
Fibroblasts and Stem Cells. Jian Wu1, 2, Y. Du3, J.
Rnjak-Kovacina4, D. Kaplan4, J. L. Funderburgh3.
1
McGowan Institute for Regenerative Medicine,
University of Pittsburgh School of Medicine,
Pittsburgh, PA; 2Ophthalmology & Surgery,
University of Pittsburgh School of Medicine,
Pittsburgh, PA; 3Ophthalmology, University
of Pittsburgh School of Medicine, Pittsburgh,
PA; 4Biomedical Engineering, Tufts University,
Medford, MA
4691 — B0260 Kinetics of apoptotic death
and oxidative damage in the retina of P23H-1
rats and the protective effects of nanoceria.
Lily L. Wong1, S. Seal3, 4, J. F. McGinnis1, 2.
1
Ophthalmology, University of Oklahoma Health
Sciences Center & Dean McGee Eye Institute,
Oklahoma City, OK; 2Cell Biology and Oklahoma
Center for Neuroscience, University of Oklahoma
Health Sciences Center, Oklahoma City, OK;
3
Advanced Materials Processing Analysis Center,
University of Central Florida, Orlando, FL;
4
Mechanical Materials Aerospace Engineering,
Nanoscience & Technology Center, University of
Central Florida, Orlando, FL *CR
4692 — B0261 Conversion of human amniotic
mesenchymal cells to retinal neural-like cells in
conditional medium. Yanqing Zhang1, H. Wang2, J.
Qian3. 1Eye and ENT Hospital of Fudan University,
Shanghai, China; 2Shanghai Xi Mei Aesthetic and
Plastic Center, Shanghai, China; 3Eye and ENT
Hospital of Fudan University, Shanghai, China
4693 — B0262 Regulation of Krüppel-like
Transcription Factor (KLF’s) Family Members
Promotes Potent Axon Regeneration in the
Adult Rat Optic Nerve. Yan Wang1, A. Apara1, M.
Blackmore2, D. P. Brown1, M. E. LeBlanc3, A. E.
Trillo1, J. L. Goldberg1. 1Ophthalmology, Bascom
Palmer Eye Institute, Miami, FL; 2Biomedical
Science, College of health science,Marquette
University, Milwaukee, WI; 3PIBS, University of
Miami, Miami, FL
4694 — B0263 Positive charged nanoemulsion
enhanced cyclosporine penetrate into cornea
after ocular topical application. Junjie Zhang,
L. Wang, T. Zhou, J. He, H. Xia, H. Zhang. Dpt
of Pharmaceutical Science, Henan Eye Institute,
Henan Eye Hospital, Zhengzhou, China
4695 — B0264 Induction of cytokeratin 3
expression in immortalized human oral mucosal
epithelial cells by the transduction of Pax6.
Yuzuru Sasamoto, R. Hayashi, M. Tsujikawa,
K. Nishida. Ophthalomology, Osaka University
Medical School, Suita, Japan *CR
4696 — B0265 Transplantation of human
retinal progenitor cells into the subretinal space
of mini pigs. Caihui Jiang, X. Wang, M. Zhang.
Ophthal-Schepens Eye Rsrch Inst, Chinese PLA
General Hospital, Beijing, China
4697 — B0266 Controlled Physical Properties
of Stem Cell Scaffolds for Photoreceptor
Regeneration. Kristan Worthington1, 3, A. K.
Salem2, A. Guymon1, B. A. Tucker3. 1Chemical and
Biochemical Engineering, University of Iowa, Iowa
City, IA; 2Pharmaceutical Science and Translational
Therapeutics, University of Iowa, Iowa City, IA;
3
Institute for Vision Research, University of Iowa,
Iowa City, IA
4698 — B0267 Development of a bioengineered
3D-model of human conjunctiva. Isabel ArranzValsero1, 2, L. Garcia-Posadas1, 2, A. Fernández3, A.
López-García1, 2, F. Iglesias3, Y. Diebold1, 2. 1Ocular
Surface Group, IOBA-University of Valladolid,
Valladolid, Spain; 2Networking Research Center on
Bioengineering, Biomaterials and Nanomedicine
(CIBER-BBN), Valladolid, Spain; 3Human Tissue
Bank, San Francisco Clinic Foundation, León,
Spain
4699 — B0268 Hybrid interphotoreceptor
matrix - poly(caprolactone) scaffolds for
human retinal progenitor cell culture and
differentiation. Michael J. Young1, A. Michaelson2,
P. Y. Baranov1, R. L. Carrier2. 1Schepens Eye
Research Inst, Massachusetts Eye and Ear, Harvard
Medical School, Boston, MA; 2Northeastern
University, Boston, MA *CR
4700 — B0269 Differentiation Of Induced
Pluripotent Stem Cells-Derived Neural Crest
Cells Into Corneal Keratocytes In Vivo.
Satoru Yoshida1, H. Miyashita1, M. Yasuda1, E.
Inagaki1, K. Tsubota1, H. Okano2, S. Shimmura1.
1
Ophthalmology, Keio University School of
Medicine, Tokyo, Japan; 2Physiology, Keio
University School of Medicine, Tokyo, Japan *CR
4701 — B0270 Nanoparticle polyethylenimineBMP7 Transfection Dose, Anti-fibrotic Efficacy
and Toxicity for the Rabbit Cornea. Chaitasi
Naik1, J. T. Rodier1, A. Sharma1, A. Stallard1, A.
Tandon1, A. Klibanov2, R. R. Mohan1. 1University
of Missouri - Columbia/Mason Eye Institue,
Columbia, MO; 2Massachusetts Institute of
Technology, Cambridge, MA
4702 — B0271 Myopia control in guinea
pigs with a biomimetic hyaluronic acidbased hydrogel. Mariana Garcia1, A. K. Jha2,
K. E. Healy2, C. F. Wildsoet1. 1Vision Science,
University of California, Berkeley, Berkeley, CA;
2
Bioengineering, University of California, Berkeley,
Berkeley, CA
4703 — B0272 Development of an Amniotic
Membrane-Based Cell Scaffold Using Super
Critical CO2 Technology. David O. Zamora1, J.
L. Wehmeyer2, H. H. Wang1, R. J. Christy2, A. J.
Johnson1. 1Ocular Trauma, U.S. Army Institute
of Surgical Research, Ft. Sam Houston, TX;
2
Extremity Trauma & Regenerative Medicine,
U.S. Army Institute of Surgical Research, Ft. Sam
Houston, TX
4704 — B0273 pRNA Nanoparticles for
Intraviteal Delivery of siRNA in Mouse Retina.
Dung V. Nguyen1, S. Caballero1, S. W. Matthews2,
J. W. Verlander2, M. E. Boulton3, P. Guo4, M. B.
Grant1. 1Pharmacology & Therapeutics, University
of Florida, Gainesville, FL; 2Medicine, University
of Florida, Gainesville, FL; 3Anatomy and Cell
Biology, University of Florida, Gainesville, FL;
4
Pharmaceutical Sciences, University of Kentucky,
Lexington, KY *CR
Exhibit Hall B0274-B0286
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
440 Strabismus: Treatment Methods
Moderator: Howard S. Ying
4705 — B0274 A comparison of inferior and
medial rectus weakening by the faden procedure.
Karen E. Grove1, 2, D. Morrison2. 1Ophthalmology,
Meharry Medical College, Nashville, TN;
2
Ophthalmology, Vanderbilt University, Nashville,
TN *CR
4706 — B0275 Infection Following Strabismus
Surgery; Why Does it Occur and and How
to Prevent it? Donny Suh. Ophthalmology
Department, University of Nebraska, West Des
Moines, IA
4707 — B0276 The role of eye axial length
in planning strabismus surgery. Maria Silvana
Galantuomo, M. Fossarello, A. Cuccu, I. Zucca.
Ophthalmology, University of Cagliari, Cagliari,
Italy
4708 — B0277 A modified transposition
technique of the superior and inferior rectus
muscles in cases with longstanding sixth nerve
palsy to reduce postoperative vertical deviation
and torsion. Ahmed Z. Soliman, A. Decanini, E. D.
Bothun. Ophthalmology, University of Minnesota,
Minneapolis, MN
4709 — B0278 Comparison of Inferior Oblique
Myectomy and Anterior Transposition on
Horizontal Deviation. Tariq S. Alshehri, H. Park.
Wilmer Eye Institute, Baltimore, MD
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
304
Wednesday – Posters – 4710 – 4732
4710 — B0279 Combined Resect and Recess
of a Single Rectus Muscle for incomitant
strabismus: review of 10 patients with emphasis
on surgical dosage. Vivek Patel1, S. Das2.
1
University of Ottawa, Ottawa, ON, Canada; 2Eye
institute, University of Ottawa, Ottawa, ON, Canada
4711 — B0280 Adjustable-suture strabismus
surgery: A new, removable, sliding noose. Emily
Deschler, K. Irsch, K. Guyton, D. L. Guyton.
Division of Pediatric Ophthalmology & Adult
StrabismusOphthalmology, The Wilmer Eye
Institute, The Johns Hopkins School of Medicine,
Baltimore, MD *CR
4712 — B0281 Medial Rectus Pulley Posterior
Fixation for Divergence excess Intermittent
Exotropia with high AC/A Ratio. Jae Ho Jung1,
H. Choi2, J. Lee1, S. Cho1, J. E. Lee2, I. Byon2.
1
Ophthalmology, Pusan Nat’l Univ Yangsan
Hospital, Yangsan, Republic of Korea; 2PNUH,
Busan, Republic of Korea
4713 — B0282 Effect of inferior oblique
weakening surgery on ocular torsion in
congenital superior oblique palsy. Jinho Lee1,
S. Suh1, 2, H. Choung1, 3, S. Kim1, 2. 1Department of
Ophthalmology, Seounl National University College
of Medicine, Seoul, Republic of Korea; 2Seoul
Artificial Eye Center, Seounl National University
Hospital Clinical Research Institute, Seoul,
Republic of Korea; 3Department of Ophthalmology,
Seoul Municipal Government-Seoul National
University Boramae Medical Center, Seoul,
Republic of Korea
4714 — B0283 Superior oblique paralysis:
treatment by the botulinum toxin A compared
to surgical treatment. Abdulaziz Aloreany1, F.
Farguette1, R. Bordas1, G. Saulnier1, H. Dalens1,
F. Chiambaretta1, H. Nezzar1, 2. 1ophthalmology,
CHU Clermont Ferrand, Clermont ferrand,
France; 2IGCNC EA 3295, Université d’Auvergne,
Clermont Ferrand, France
4716 — B0285 The Effect of a TemperatureSensitive Poloxamer/Alginate/CaCl2 Mixture
After Strabismus Surgery in a Rabbit Model.
Won Yeol Ryu, H. Jung, Y. Kwon, W. C. Park, H.
Ahn. Department of Ophthalmology, Dong-A
University College of Medicine, Busan, Republic
of Korea
4717 — B0286 Can Tropicamide 1%
Ophthalmic Solution act as a Potential Adjunct
Treatment for Post Concussive Visual and
Ocular Motor Symptoms? Lynn D. Greenspan.
Foundations of Optometric Medicine, Salus
University, Elkins Park, PA
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Cornea
441 Corneal Development,
Differentiation, Dystrophies, Genetics
Moderator: Mario Matthaei
4718 — C0101 Role of Shp2 Protein
Phosphatase in Mouse Corneal Epithelium
Stratification. Chia-Yang Liu1, G. Ng1, L. Yeh2, 1,
H. Liu1, Y. Zhang1, W. W. Kao1. 1Ophthalmology,
Univ of Cincinnati, Cincinnati, OH; 2Department of
Ophthalmology, Chang-Gung Memorial Hospital,
Linko, Taiwan
4719 — C0102 The homeodomain transcription
factor PITX2 is required to establish correct
cell lineages and angiogenic privilege in the
developing cornea. Philip J. Gage, A. L. Zacharias,
C. Kuang. Ophthal & Vis Science, Univ MichiganKellogg Eye Ctr, Ann Arbor, MI
4720 — C0103 Expression patterns of
angiogenic factors correlate with vascular
patterning of the developing anterior eye.
Sam Kwiatkowski, R. P. Munjaal, P. Y. Lwigale.
Biochemsitry and Cell Biology, Rice University,
Houston, TX
4721 — C0104 Role of Netrin-4 and Laminin
β2 and γ3 Chains in Corneal Development and
Maintenance. Jeremiah Martino1, 2, G. Bachay1, 2,
M. A. Dattilo1, 2, D. R. Lazzaro1, 2, W. J. Brunken1, 2.
1
Ophthalmology and Cell Biology, SUNY
Downstate Medical Ctr, Brooklyn, NY; 2SUNY Eye
Institute, Brooklyn, NY
4722 — C0105 Ocular Manifestations of
X-linked Reticulate Pigmentary Disorder. Kruti
Dajee, H. D. Cavanagh, N. Hogan, L. A. Baker, A.
R. Zinn, V. V. Mootha. Ophthalmology, University
of Texas Southwestern Medical Center, Dallas, TX
*CR
4723 — C0106 Novel CHRLD1 Mutation and
Secondary Glaucoma in Patient with X-Linked
Megalocornea. Xin Gong, J. T. Whitson, V. V.
Mootha. Ophthalmology, UT Southwestern Medical
Center, Dallas, TX *CR
4724 — C0107 An intronic TCF4 tri-nucleotide
repeat expansion associated with Fuchs Corneal
Dystrophy. S. Amer Riazuddin1, B. C. Gapsis1, N.
Katsanis2, J. D. Gottsch1. 1The Wilmer Eye Institute,
Johns Hopkins Univ Sch of Med, Baltimore,
MD; 2Center for Human Disease Modeling, Duke
University Medical Center, Durham, NC
4725 — C0108 An Investigation of
Mitochondrial Haplogroups in Fuchs
Endothelial Corneal Dystrophy. Yi-Ju Li1, 2, M. A.
Minear2, J. Rimmler2, E. Balajonda3, M. A. Hauser2,
R. Allingham3, G. K. Klintworth3, 4, S. G. Gregory2,
N. A. Afshari5, 3. 1Biostatistics and Bioinformatics,
Duke University Medical Center, Durham, NC;
2
Center for Human Genetics, Medicine, Duke
University Medical Center, Durham, NC; 3Duke
University Eye Center, Duke University Medical
Center, Durham, NC; 4Pathology, Duke University
Medical Center, Durham, NC; 5Shiley Eye Center,
University of California San Diego, San Diego, CA
*CR
4726 — C0109 Impaired mitochondrial
membrane potential in Fuchs endothelial corneal
dystrophy. Cecily E. Hamill1, 2, T. Schmedt1, 2, Y.
Chen1, 2, U. V. Jurkunas1, 2. 1Massachusetts Eye
and Ear Infirmary, Boston, MA; 2Schepens Eye
Research Institute, Boston, MA *CR
4727 — C0110 Abnormal extracellular matrix
production in corneal endothelial cells from
patients with late-onset Fuchs corneal dystrophy.
Julia M. Wessel, M. Zenkel, U. SchlotzerSchrehardt, B. O. Bachmann, T. Tourtas, F. E.
Kruse. Department of Ophthalmology, University of
Erlangen-Nuremberg, Erlangen, Germany
4728 — C0111 Three novel mutations in
COL8A2 gene of Korean patients with Fuchs’
endothelial corneal dystrophy. Kyu-yeon
Hwang1, 2, J. Mok2, C. Rho3, 2, C. Joo1, 2. 1Department
of Ophthalmology & Visual Science, Seoul
St.Mary`s hospital, the catholic university of Korea,
Seoul, Republic of Korea; 2Catholic Institutes
of Visual Science, The Catholic University of
Korea, Seoul, Republic of Korea; 3Department
of Ophthalmology & Visual Science, Deajeon St.
Mary`s hospital, The Catholic University of Korea,
Dae-jeon, Republic of Korea
4729 — C0112 Posterior Polymorphous
Corneal Dystrophy 3 Associated with Agenesis
of the Corpus Callosum. Michelle Jang, A. N.
Roldan, R. F. Frausto, A. J. Aldave. Doris Stein,
Cornea Division, Jules Stein Eye Institute, UCLA,
Los Angeles, CA *CR
4730 — C0113 Posterior Polymorphous
Corneal Dystrophy is Associated with Steep
Corneal Curvature. Lydia Ann, R. F. Frausto,
F. Yu, C. K. Nguyen, A. J. Aldave. Jules Stein Eye
Institute (UCLA), Los Angeles, CA *CR
4731 — C0114 Identification of Genetic
Variant Candidates for Posterior Polymorphous
Corneal Dystrophy 1 utilizing Next-Generation
Sequencing. Ricardo F. Frausto, J. Han, A. J.
Aldave. Doris Stein, Cornea Division, Jules Stein
Eye Institute, UCLA, Los Angeles, CA *CR
4732 — C0115 Exclusion of Pathogenic
Promoter Region Variants and Identification of
Novel Nonsense Mutations in ZEB1 in Posterior
Polymorphous Corneal Dystrophy. Pejman
Bakhtiari, R. F. Frausto, A. N. Roldan, C. Wang,
A. J. Aldave. Jules Stein Eye Institue, Los Angeles,
CA *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
305
Wednesday Posters
11:00 am – 12:45 pm
4715 — B0284 Correction of accommodative
factor in patients with residual esotropia after
treatment with botulinum toxin for infantile
esotropia. Mario I. Torres Garcia, R. A. Martinez,
M. Acosta Silva, M. A. Najera Covarrubias, K.
Calderon Soto. Estrabismo, Hospital Fundacion
Nuestra Señora de la Luz, Distrito Federal, Mexico
Exhibit Hall C0101-C0125
4733 – 4754 – Wednesday – Posters
4733 — C0116 Identification by whole-exome
next-generation sequencing of coding region
mutations as candidates for posterior amorphous
corneal dystrophy. Jonathan Han, R. F. Frausto,
M. J. Kim, A. J. Aldave. Doris Stein, Cornea
Division, Jules Stein Eye Institute, Los Angeles,
CA *CR
4734 — C0117 Lattice corneal dystrophy,
type 1 (LCD1): an epithelial or stromal entity ?
Walter Lisch1, B. Seitz2. 1Ophthalmology, Johannes
Gutenberg University Mainz, Mainz, Germany;
2
Ophthalmology, Saarland University, Homburg/
Saar, Germany
4735 — C0118 Proteolytic processing in lattice
corneal dystrophy. Ebbe Toftgaard Poulsen1, K.
Runager1, M. W. Risør1, I. Thøgersen1, T. Dyrlund1,
L. R. Thomsen1, G. K. Klintworth2, J. J. Enghild1.
1
Department of Molecular Biology, Aarhus
University, Aarhus C, Denmark; 2Departments of
Pathology and Ophthalmology, Duke University,
Durham, NC
4736 — C0119 Benzalkonium chloride
accelerates amyloid fibril formation in corneal
dystrophies in vitro. Yuichi Kaji1, 2, H. Yagi2,
Y. Kato2, Y. Goto2, T. Oshika1. 1Ophthalmology,
University of Tsukuba, Ibaraki, Japan; 2Laboratory
of Protein Folding, Institute for Protein Research
Osaka University, Osaka, Japan
Wednesday Posters
11:00 am – 12:45 pm
4737 — C0120 Exploring the mechanism
underlying the protein aggregation in stromal
corneal dystrophies caused by amyloidogenic
and non-amyloidogenic mutants of TGFBIp.
Elavazhagan Murugan1, R. Lakshminarayanan1, R.
W. Beuerman1, 2, S. S. Chaurasia1, J. S. Mehta1, 2.
1
Tissue engineering and stem cell research group,
Singapore Eye Research Institute, Singapore,
Singapore; 2Singapore National Eye Centre,
Singapore National Eye Centre, Singapore,
Singapore *CR
4738 — C0121 Insights into the molecular
mechanisms of TGFBIp aggregation in corneal
dystrophies. Kasper Runager1, 2, J. Underhaug1, C.
S. Sørensen1, 2, H. Karring3, G. K. Klintworth4, N.
C. Nielsen1, J. J. Enghild2, 1. 1Center for Insoluble
Protein Structures, Aarhus University, Aarhus,
Denmark; 2Department of Molecular Biology and
Genetics, Aarhus University, Aarhus, Denmark;
3
Institute of Chemical Engineering, University
of Southern Denmark, Odense M, Denmark;
4
Departments of Pathology and Ophthalmology,
Duke University Medical Center, Durham, NC
4739 — C0122 An inducible transgenic
mouse model of TGFBI-related corneal stromal
dystrophy. Andrew J. Huang1, C. Liu2, Y. Zhang2,
H. Liu2. 1Ophthalmology & Visual Sciences,
Washington Univ School of Med, St Louis,
MO; 2Ophthalmology, University of Cincinnati,
Cincinnati, OH
4740 — C0123 Identification of TGFBI gene
mutations in Polish patients with corneal
dystrophies. Monika Udziela1, M. Oldak2, 1, J.
P. Szaflik1, A. Federowicz2, R. B. Maksym2, R.
Ploski3, J. Szaflik1. 1Department of Ophthalmology,
Medical University of Warsaw, Warsaw, Poland;
2
Department of Histology and Embryology,
Medical University of Warsaw, Warsaw, Poland;
3
Department of Medical Genetics, Medical
University of Warsaw, Warsaw, Poland
4741 — C0124 The degree of exacerbated
interfacial opacity after LASIK in Granular
Corneal Dystrophy type 2 is related with the
width of area of granular deposits made before
procedure. Eung Kweon Kim, T. Rim, H. Kim,
T. Kim. Ophthalmology, Yonsei Univ College of
Medicine, Seoul, Republic of Korea
4742 — C0125 shRNA Gene-silencing Therapy
for Congenital Stromal Corneal Dystrophy. Rajiv
R. Mohan, A. Sharma, J. T. Rodier, A. Tandon, D. E.
Birk. Mason Eye Institute, University of MissouriColumbia, Columbia, MO
Exhibit Hall D0127-D0181
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Glaucoma
442 Surgery and Wound Healing
Moderator: Tina Wong
4743 — D0127 Prospective evaluation of
medical therapy to prevent the hypertensive
phase following implantation of a glaucoma
drainage device. Helen L. Kornmann, A. Kwong, J.
A. Giaconi, J. Caprioli, S. K. Law. Ophthalmology,
Jules Stein Eye Institute, Los Angeles, CA *CR, f
4744 — D0128 High Intensity Focused
Ultrasound (HIFU) in patients with Refractory
Glaucoma. Shlomo Melamed, M. Goldenfeld, D.
Cotlear, A. Skaat. Goldschleger Eye Institute, Sheba
Medical Center, Ramat Gan, Israel *CR, f
4745 — D0129 Ahmed Glaucoma Valve versus
Gold Micro Shunt (GMS) implants - Five years
Results of a Prospective Randomized Clinical
Trial. Iris Moroz, S. Melamed, O. Sagiv, G. J. Ben
Simon, M. Goldenfeld, A. Skaat. Goldschleger Eye
Institute, Tel Hashomer, Israel *CR, f
4746 — D0130 Graft-free Ahmed valve
implantation through a 6mm scleral tunnel.
Kailun Jiang1, G. Gdih2. 1The Ottawa Hospital,
Ottawa, ON, Canada; 2University of Manitoba,
Winnipeg, MB, Canada
4747 — D0131 The PLGA implant as an
antimitotic delivery system after experimental
trabeculectomy. Ignacio Rodriguez-Agirretxe1, 2,
S. Vega3, E. Vecino4, J. Mendicute2, F. Eder2, T.
M. Suarez-Cortes3, A. Acera3. 1Glaucoma, ICQO,
Bilbao, Spain; 2Glaucoma, Donostia Hospital,
San Sebastian, Spain; 3Bioftalmik SL, Derio,
Spain; 4Cellular Biology, University of the Basque
Country, Leioa, Spain *CR
4748 — D0132 Corneal Endothelial Cells
Loss After Trabeculectomy For Glaucoma.
Juan A. Dios1, 2, M. E. Delgado2, V. V. Castro3.
1
Ophthalmology, Clinica Ricardo Palma, Lima,
Peru; 2Ophthalmology, Hospital Alberto Sabogal
Sologuren, Callao, Peru; 3Ophthalmology, Hospital
Nacional Arzobispo Loayza, Lima, Peru
4749 — D0133 Comparison of surgical
outcomes between 360 degree catheter assisted
and traditional 180 degree trabeculotomy in
patients with congenital glaucoma. Monisha
Mandalaywala Vora1, 3, C. H. Marcus1, 2, R.
F. Rothman1, 2, D. D. Hayes1, 2, A. Angelilli1, 2.
1
Ophthalmology, North Shore Long Island Jewish
Medical Center, Great Neck, NY; 2Glaucoma
Consultants of Long Island, Lake Success, NY;
3
Hofstra School of Medicine, Lake Success, NY
4750 — D0134 Long term Intraocular
Pressure Control Using Combined Endoscopic
Cyclophotocoagulation (ECP) And
Phacoemulsification in the Treatment of Mild to
Moderate Glaucoma - 5 Year Results. Michael
J. Siegel1, W. Boling5, O. S. Faridi6, C. K. Gupta3,
M. S. Juzych1, 2, M. Citron3, 4, M. J. Siegel3, 4,
L. I. Siegel3, 4. 1Ophthalmology, Kresge Eye
Institute, Detroit, MI; 2School of Medicine, Wayne
State University, Detroit, MI; 3Ophthalmology,
WIlliam Beaumont Hospital, Royal Oak, MI;
4
Ophthalmology, Glaucoma Center of Michigan,
Southfield, MI; 5Internal Medicine, Detroit
Medical Center, Detroit, MI; 6Ophthalmology, Eye
Physicians & Surgeons, PC of Connecticut, Milford,
CT
4751 — D0135 Longitudinal Study of Corneal
Endothelial Damage After Anterior Tube Shunt
Surgery. Koichi Ono1, T. Hamanaka2, S. Kimura1.
1
Department of Ophthalmology, Juntendo Tokyo
Koto Geriatric Medical Center, Juntendo University
School of Medicine, Koto-ku, Japan; 2Department
of Ophthalmology, Japanese Red Cross Medical
Center, Shibuya-ku, Japan
4752 — D0136 Outcomes of combined
glaucoma tube shunt and fluocinolone acetonide
implant placement in uveitic patients compared
to outcomes in uveitic and open angle glaucoma
patients with glaucoma tube shunt placement
alone. Daniel B. Moore, S. Asrani. Ophthalmology,
Duke Eye Center, Durham, NC
4753 — D0137 The effect of aqueous
humour protein content and viscosity on
equilibrium pressure under the scleral flap in
trabeculectomies. Amir Samsudin1, 2, I. Eames3, S.
Brocchini2, 4, P. T. Khaw2. 1University of Malaya,
Kuala Lumpur, Malaysia; 2NIHR Biomedical
Research Centre at Moorfields Eye Hospital
NHS Foundation Trust and UCL Institute of
Ophthalmology, London, United Kingdom; 3UCL
Department of Mechanical Engineering, London,
United Kingdom; 4UCL School of Pharmacy,
London, United Kingdom *CR
4754 — D0138 Outcomes of Pars Plana
Baerveldt Glaucoma Drainage Implant in Boston
Type 1 Keratoprosthesis Surgery. Eun S. Huh, A.
A. Aref, T. S. Vajaranant, J. De la Cruz, F. Y. Chau,
M. S. Cortina. Ophthalmology, Univ of Illinois Eye
& Ear Infirm, Chicago, IL *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
306
Wednesday – Posters – 4755 – 4782
4755 — D0139 The Effect of Trabeculectomy
on Astigmatism. Heleen Delbeke, I. Stalmans, E.
Vandewalle, T. Zeyen. Ophthalmology, University
hospitals Leuven, Leuven, Belgium f
4756 — D0140 Initial Results of Treatment of
Advanced Glaucoma with Ahmed Wing Valve.
Jennifer Oakley1, C. Capitena1, D. W. Richards1, W.
E. Layden2. 1University of South Florida, Tampa,
FL; 2University Glaucoma Center, Tampa, FL
4757 — D0141 Comparison of the outcomes
of Trabectome with Trabeculotomy with
deep Sclerectomy - Ab Interno vs Ab Externo
approach. Masahiro Maeda1, 2, N. Kondo2, K.
Onuki2, A. Hasegawa3. 1University of California,
Irvine, Irvine, CA; 2Gifu Red Cross Hospital, Gifu,
Japan; 3Social Insurance Chukyo Hospital, Nagoya,
Japan
4758 — D0142 Comparison of Surgical
Outcomes of the Ex-PRESS Glaucoma Filtration
Device with Mitomycin C in Phakic and
Pseudophakic Eyes. Sarwat Salim, J. Wan, H. Du.
Ophthalmology, Hamilton Eye Institute, Memphis,
TN *CR
4759 — D0143 Ex-press mini-implant in the
management of ocular hypertension secondary
to silicon oil tamponade. Nicola Cardascia, F.
Cantatore, P. Ferreri, F. Boscia, L. Sborgia, G.
Alessio. Ophthalmology, Università di Bari A Moro,
Bari, Italy
4760 — D0144 Prospective morphological
subconjunctive analysis by spectral domain
optical coherence tomography of blebless
glaucoma surgeries. J. Aritz Urcola1, 2,
C. Dalmasso1, J. Cabrerizo1, A. Latorre3.
1
Ophthalmology, Hospital Universitario Araba,
Vitoria-Gasteiz, Spain; 2Opthalmology, Begitek
Clínica Oftalmológica, Donostia-San Sebastián,
Spain; 3Research and development, Hospital
Universitario Araba, Vitoria-Gasteiz, Spain
4762 — D0146 Long Term Outcomes
of Filtration Surgery for Normal-Tension
Glaucoma with Visual Field Progression at Low
Intraocular Pressure. Scott K. Schultz, S. M.
Iverson, W. Shi, J. C. Schiffman, D. S. Greenfield.
Ophthalmology, Bascom Palmer Eye Institute, Palm
Beach Gardens, FL *CR
4763 — D0147 Corneal Endothelial Cell
Density and Filtration Surgery in Patients with
Posner-Schlossman Syndrome. Yuko Maruyama1,
K. Mori1, M. Ueno1, Y. Ikeda1, K. Maruyama2, S.
Kinoshita1. 1Ophthalmology, Kyoto Prefectural
Univ of Med, Kyoto, Japan; 2Ophthalmology,
Tohoku University Graduate School of Medicine,
Sendai, Japan *CR
4764 — D0148 A Comparison of Sequential
Glaucoma Drainage Device Implantation versus
Cyclophotocoagulation Following Failure of
a Primary Drainage Device. Joshua Levinson,
A. Giangiacomo, A. D. Beck, P. B. Pruett, A.
Costarides. Ophthalmology, Emory University,
Atlanta, GA
4766 — D0150 The outcome of two different
tube ligation methods in Baerveldt implant
surgery. Shuri Kawamorita1, T. Hamanaka1, T.
Sakurai2. 1Japanese Red Cross Medical Center,
Tokyo, Japan; 2Tokyo University of Science Suwa,
Nagano, Japan
4767 — D0151 Tube Shunt versus
Trabeculectomy Surgery in Patients with
Glaucoma Associated with Ocular Inflammation.
Cecilia S. Lee, A. Y. Lee, A. Bhorade, H. Karacal.
Ophthalmology, Washington University in St.
Louis, St. Louis, MO *CR
4768 — D0152 Foreign Body Reaction in
Glaucoma Drainage Implant Surgery. Kyoung In
Jung, C. Park. Department of Ophthalmology and
Visual Science, Seoul St. Mary’s Hospital,College
of Medicine, The Catholic University of Korea,
Seoul, Republic of Korea
4769 — D0153 An Engineering Model for
Predicting the Aqueous Humor Flow Rate
through the Natural Pathway Following
Glaucoma Surgeries. Joseph Nelly Sugu Sugira,
M. J. Rickard. College of Engineering, California
Baptist University, Riverside, CA
4770 — D0154 Tube Exposures in Glaucoma
Drainage Devices. Paramdeep S. Mand, P. P. Chen,
M. A. Slabaugh. Ophthalmology, University of
Washington, Seattle, WA *CR
4771 — D0155 The Effect of Adjuvant
Mitomycin C in Ahmed Glaucoma Valve Surgery
For Refractory Glaucoma. Melissa Tien, L. W. Yip,
E. Wong, V. Yong, H. Wong, B. Lim. Ophthalmology,
National Healthcare Group Eye Institute, Tan Tock
Seng Hospital, Singapore, Singapore f
4772 — D0156 Repairing filtration bleb
leakage with FocalSeal® in rabbit model. Tatsuo
Nagata1, Y. Harada1, H. Kondo1, M. Arai2, 3,
A. Tawara1. 1Ophthalmology, University of
Occupational and Environmental Health, Japan,
Fukuoka, Japan; 2Arai Eye Clinic, Fukuoka, Japan;
3
Schepens Eye Research Institute, Harvard Medical
School, Boston, MA
4773 — D0157 Ultrasound biomicroscopy
findings after suprachoroidal cypass implant for
glaucoma: one year follow-up. Elisa Gonzalez
Pastor, M. C. Bermudez, L. Morales-Fernandez,
J. M. Martinez de la Casa, J. Garcia-Feijoo.
Glaucoma, Hospital Clinico San Carlos, madrid,
Spain *CR
4774 — D0158 Complementary effects of
bevacizumab and MMC in the improvement
of surgical outcome after glaucoma filtration
surgery. Tine Van Bergen1, K. P. Hollanders1, D.
Sijnave1, S. Van de Velde1, E. Vandewalle1, L. K.
Moons2, I. Stalmans1. 1Lab of Ophthalmology, KU
Leuven, Leuven, Belgium; 2Department of Biology,
Zoological Institute, KU Leuven, Leuven, Belgium
*CR
4775 — D0159 Ultrasonic Circular Cyclo
Coagulation in patients with Primary OpenAngle Glaucoma: a Multicenter Clinical
Trial. Florent Aptel1, P. Denis2, J. J. Rouland3,
J. Nordmann4, Y. M. Lachkar5, J. G. Renard6, E.
Sellem7, C. Baudouin4, A. M. Bron8. 1Grenoble
University Hospital, Grenoble, France; 2Hôpital de
la Croix-Rousse, Hospices Civils de Lyon, Lyon,
France; 3Hôpital Claude Huriez, CHRU de Lille,
Lille, France; 4Centre Hospitalier National des
Quinze-Vingts, Paris, France; 5Institut du glaucome,
Fondation Hôpital Saint-Joseph, Paris, France;
6
Hôpital d’Instruction des Armées du Val de Grâce,
Paris, France; 7Centre Ophtalmologique Kléber,
Lyon, France; 8Dijon University Hospital, Dijon,
France *CR, f
4776 — D0160 The Effect of Early Post-op
Anti-Hypertensive Agents on the Hypertensive
Phase following Ahmed FP 7 Glaucoma Valve
Implantation, a Retrospective Review. Brenton
Finklea, A. Gupta, S. M. Johnson. Ophthalmology,
University of Virginia, Charlottesville, VA *CR
4777 — D0161 A comparative study of
combined trabeculectomy with ECCE/PCIOL
versus Ex-press Shunt with ECCE/PCIOL.
Farvah Fatima1, 2, B. A. Hughes1, 2, R. Momi1, 2,
J. Tannir1, 2, M. S. Juzych1, 2, C. Kim1, 2, M. H.
Peracha1, 2, A. M. Eby1, 2, M. McQueen1, 2. 1Wayne
State University School of Medicine, Detroit, MI;
2
Kresge Eye Institute, Detroit, MI
4778 — D0162 Efficacy and Safety of
Intracameral Triesence™ Use in Glaucoma
Surgery. Michael Koval, M. R. Moster, K. B.
Freidl, M. J. Pro, J. S. Myers. Glaucoma, Wills Eye
Institute, Philadelphia, PA *CR, f
4779 — D0163 Acute Intra-ocular Pressure
(IOP) Changes Following Cataract Surgery
With and Without Trabectome™ Ab-interno
Trabeculectomy. Asher Weiner1, Y. Weiner2.
1
Ophthalmic Consultants of the Capital Region,
Albany, NY; 2Undergraduate, University of
Michigan, Ann-Arbor, MI
4780 — D0164 Patients presenting with severe
glaucomatous visual field defect benefit from
both surgical and medical treatment. Eugenio
J. Maul de la Puente, J. A. Tapia, A. Kastner.
Ophthalmology, Universidad Catolica, Santiago,
Chile
4781 — D0165 Experience in the Use of
the Express Device Without Mytomicin C in
Patients With Primary Open Angle Glaucoma.
Cristina G. Isida Llerandi, H. Bello Lopez Portillo,
R. Castañeda Diez, M. García-Huerta, F. Gil
Carrasco, J. Jimenez-Roman, M. Turati-Acosta, L.
A. ZARATE. Glaucoma, Asociación para Evitar la
Ceguera en México, Coyoacan, Mexico
4782 — D0166 Investigation of the filtration
surgery with FocalSeal® in rabbit’s eyes. Yukinori
Harada1, T. Nagata1, M. Arai2, 3, A. Tawara1.
1
Department of Ophthalmology, University of
Occupational & Environmental Health, Kitakyushu,
Japan; 2Arai Eye Clinic, Fukuoka, Japan; 3Schepens
Eye Research Institute, Harvard Medical School,
Boston, MA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
307
Wednesday Posters
11:00 am – 12:45 pm
4761 — D0145 Refractive outcome after
phacoemulsification following trabeculectomy.
Oliver L. Yeh, P. P. Chen. Ophthalmology,
University of Washington, Seattle, WA *CR
4765 — D0149 Retrobulbar Shunt (RS) for
Encapsulated Blebs. Sylvia L. Groth1, W. E.
Sponsel2. 1University of Minnesota Medical School,
Minneapolis, MN; 2University of Texas - San
Antonio, Biomedical Engineering; WESMDPA
Glaucoma Service, San Antonio, TX *CR
4783 – 4805 – Wednesday – Posters
4783 — D0167 Long-term results after Ahmed
glaucoma valve implantation for different types
of glaucoma. Olga Furashova, K. R. Pillunat, E.
Spoerl, L. E. Pillunat. Ophthalmology, University
Hospital, Dresden, Germany f
4784 — D0168 Efficacy of Goniosynechialysis
for Chronic Angle-Closure Glaucoma. Guoping
Qing, D. Mou. Beijing Tongren Eye Center, Beijing
Tongren Hospital, Beijing, China f
4785 — D0169 Imaging of Surgical Blebs
using Spectral Domain Optical Coherence
Tomography. Giovanni Milano1, 2, M. Raimondi1, 2,
S. Lanteri1, 2, S. Lombardo1, 2, A. Verticchio
Vercellin1, 2, C. Cutolo1, 2, L. Bossolesi2, 1, G. C.
Rossi2, 1. 1University Eye Clinic, University of
Pavia, Pavia, Italy; 2Fondazione IRCCS Policlinico
San Matteo, pavia, Italy *CR
4786 — D0170 Fibrovascular ingrowth - a
common cause of Glaucoma Drainage Device
failure in refractory pediatric glaucoma. Irene
Tung, I. Marcus, W. Thiamthat, E. Dosunmu, S. F.
Freedman. Duke Eye Center, Durham, NC *CR
4787 — D0171 Association of Aqueous
Humor Dynamic Markers in Glaucoma With
Canaloplasty Surgery. David M. Reed, J. L.
Gilbert, S. E. Moroi. Ophthalmology & Visual
Sciences, University of Michigan, Ann Arbor, MI
*CR
Wednesday Posters
11:00 am – 12:45 pm
4788 — D0172 The effect of the Hydrus
trabecular shunt on endothelial cell count: a
double blind prospective randomized clinical
study. Antonio M. Fea, G. Consolandi, G. Pignata,
P. Cannizzo, M. Dal Vecchio, F. Gallozzi, C. Lavia,
T. Rolle, F. M. Grignolo. Ophth/I Clinica Oculistica,
Universita di Torino, Torino, Italy *CR, f
4789 — D0173 Comparison short term post
operative hypotony rates of 23 gauge versus 25
gauge needle size in the formation of a corneascleral track for Baerveldt tube insertion into the
anterior chamber. Kirithika Muthusamy, J. Cheng,
K. Barton, K. Lim, L. Beltran-Agullo. Glaucoma,
Moorfields Eye Hospital, London, United Kingdom
*CR
4790 — D0174 IOP-lowering and Safety
Associated with Opening Gold Micro Shunt’s
Windows. Nicolas Cadet, P. Harasymowycz.
Ophthalmology, Universite de Montreal, Montreal,
QC, Canada *CR
4791 — D0175 Persistent hypotony associated
to the use of immunosuppressive therapy in
glaucoma drainage implants. Susana Duch,
O. Stirbu, E. Milla, O. Buchacra Castellano.
Ophthalmology- Glaucoma, Institut Condal
d’Oftalmologia, Barcelona, Spain
4792 — D0176 Retrospective review of
patients with refractory glaucoma treated with
Transcleral Diode Laser Cyclophotocoagulation.
Vikas Tah2, S. Pasu1, S. Shah1. 1Glaucoma, St Helier
Hospital, London, United Kingdom; 2Oxford Eye
Hospital, Harrow, United Kingdom
4793 — D0177 Comparison of IOP and
postoperative complications in patients
undergoing tube shunt or trabeculectomy
surgery for uveitis-related intraocular pressure
elevation. Umair Iqbal, M. Bal, R. R. Buhrmann,
C. C. Gottlieb. University of Ottawa Eye Institute,
Ottawa, ON, Canada *CR
4794 — D0178 Comparison between
Endhotelial Cell Loss After MICS Phaco
with ExPress Implant and MICS Phaco SafeTrabeculectomy. Romeo Altafini, S. Morselli.
Ophthalmology Unit, San Bassiano Hosp, Bassano
del Grappa, Vicenza, Italy
4795 — D0179 The relationship between
skin phototype and trabeculectomy outcome.
Jonathan C. Clarke1, 2, M. Lee1, 3, A. Khalili2, S.
Dhingra1, 2, C. Bunce2, P. T. Khaw1, 2. 1Glaucoma
Service, Moorfields Eye Hospital, London, United
Kingdom; 2NIHR Biomedical Research Centre
for Ophthalmology, Moorfields Eye Hospital and
UCL Institute of Ophthalmology, London, United
Kingdom; 3Kuala Lumpur Hospital, Kuala Lumpur,
Malaysia *CR
4796 — D0180 Rosmarinic Acid Suppresses
Responses By Fibroblasts Contributing To
Fibrosis Following Glaucoma Filtration
Surgery. Jayter S. Paula1, C. Modulo1, M. C.
Frade2, P. Reinach1, E. M. Rocha1. 1Department
of Ophthalmology, FMRP - USP, Ribeirao Preto,
Brazil; 2Internal Medicine Department, FMRP USP, Ribeirao Preto, Brazil
4797 — D0181 Incidence and success rates
of trabeculectomy with ExPress mini shunt
following failed canaloplasty. Jacob W. Brubaker,
M. A. Khaimi. Ophthalmology, Dean McGee Eye
Institute, University of Oklahoma, Oklahoma City,
OK *CR
Exhibit Hall D0237-D0291
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Glaucoma
443 Imaging III, GL
Moderators: Christopher K. Leung and
Larry Kagemann
4798 — D0237 Glaucoma progression detection
using a Bayesian-fuzzy logic approach applied
to 3D spectral domain optical coherence
tomography optic nerve head images. Akram
Belghith, C. Bowd, R. N. Weinreb, A. J. Tatham, A.
Miki, F. A. Medeiros, L. M. Zangwill. Department of
Ophthalmology-0946, Hamilton Glaucoma Center,
La Jolla, CA *CR
4799 — D0238 Changes in Anterior Segment
Morphology after Laser Iridotomy in Asian
Indian Eyes: A Source Swept Anterior Segment
Optical Tomography Study. Rajesh Sasikumar, T.
Patil, S. A. Devi, D. Rao, R. Balu, N. K. Puttaiah,
B. K. Shetty. Glaucoma and Research, Narayana
Nethralaya, Bangalore, India
4800 — D0239 Intersubject correlation
between circumpapillary distribution of retinal
nerve fiber layer and retinal vessels: comparison
between optical coherence tomography and
scanning laser polarimetry. Ivania Pereira1, S.
Holzer1, H. Resch1, B. Kiss1, G. Fischer2, C. Vass1.
1
Ophthalmology & Optometry, Medical University
Vienna, Vienna, Austria; 2Center for Medical
Statistics Informatics and Intelligent Systems,
Section for Medical Information Management
and Imaging, Medical University Vienna, Vienna,
Austria
4801 — D0240 Topographic Correlation
between Ganglion Cell-Inner Plexiform Layer
and Circumpapillary Retinal Nerve Fiber
Layer Defect using Spectral Domain Optical
Coherence Tomography. Ki Ho Park1, 2, K. Kim1, 2,
J. Jeoung1, 2, S. Kim1, 3, D. Kim1, 2. 1Ophthalmology,
Seoul National University College of Medicine,
Seoul, Republic of Korea; 2Ophthalmology, Seoul
National University Hospital, Seoul, Republic
of Korea; 3Ophthalmology, SMG-SNU Boramae
Medical Center, Seoul, Republic of Korea
4802 — D0241 Detecting Glaucomatous
Structural Changes in Glaucoma Suspect Eyes
Using a Cohort of Stable Glaucoma Patients.
Naama Hammel1, L. M. Zangwill1, A. Miki1, S. Jain2,
F. He2, N. Khachatryan1, J. M. Liebmann3, 4, C. A.
Girkin5, F. A. Medeiros1, R. N. Weinreb1. 1Hamilton
Glaucoma Center, Department of Ophthalmology,
University of California, San Diego, La Jolla, CA;
2
Department of Family and Preventive Medicine,
University of California, San Diego, La Jolla, CA;
3
New York University School of Medicine, New
York, NY; 4Department of Ophthalmology, Einhorn
Clinical Research Center, New York Eye and Ear
Infirmary, New York, NY; 5School of Medicine,
University of Alabama, Birmingham, AL *CR, f
4803 — D0242 Evaluation of retinal nerve fiber
layer retardation, thickness and birefringence
along the major nerve fiber bundles measured
with polarization sensitive OCT. Stefan Zotter1,
M. Pircher1, T. Torzicky1, B. Baumann1, P. K.
Roberts2, 1, I. Pereira2, S. Holzer2, C. Vass2, U.
Schmidt-Erfurth2, C. K. Hitzenberger1. 1Center
for Med. Phys. and Biomed. Eng., Medical
University of Vienna, Vienna, Austria; 2Department
of Ophthalmology and Visual Sciences, Medical
University of Vienna, Vienna, Austria *CR
4804 — D0243 In-Vivo Microstructural
Anatomy of Parapapillary Atrophy: Beta-Zone
and Gamma- Zone. Yi Dai1, J. B. Jonas2, H.
Huang1, M. Wang1, X. Sun1. 1Ophthalmology, EYE
& ENT Hospital, Shanghai, China; 2Ophthalmology,
Medical Faculty Mannheim of the Ruprecht-KarlsUniversity, Heidelberg, Germany *CR
4805 — D0244 Comparison of birefringencerelated data between scanning laser polarimetry
(GDx) and polarization sensitive optical
coherence tomography (PS-OCT). Clemens
Vass1, I. Pereira1, S. Zotter2, S. Holzer1, H.
Resch1, M. Pircher2, C. K. Hitzenberger2. 1Dept
of Ophthalmology, Medical University of Vienna,
Vienna, Austria; 2Center for Medical Physics and
Biomedical Engineering, Medical University of
Vienna, Vienna, Austria *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
308
Wednesday – Posters – 4806 – 4827
4806 — D0245 Agreement between Clinical
versus Automated Disc Damage Likelihood
Scalw (DDLS) Staging in Asian Indian eyes.
Premnath Gnaneswaran, S. A. Devi, R. Balu,
D. Rao, N. K. Puttaiah, R. Shetty, R. Sasikumar.
Glaucoma, Narayana Nethralaya, Bangalore, India
4807 — D0246 Multiple linear regression
analysis between circumpapillary retinal nerve
fiber layer thickness profiles measured with
scanning laser polarimetry and retinal blood
vessel thickness, optic disc parameters and age.
Hemma Resch1, I. Pereira1, S. Holzer1, B. Kiss1, G.
Fischer2, C. Vass1. 1Ophthalmology and Optometry,
Medical Universitiy of Vienna, Austria, Vienna,
Austria; 2Center for Medical Statistics Informatics
and Intelligent Systems, Section for Medical
Information Management and Imaging, Medical
Universitiy of Vienna, Austria, Vienna, Austria
4808 — D0247 Influence of Anterior Segment
Biometric Parameters on the Anterior Chamber
Angle Width in Eyes with Angle Closure and
Open Angle. Takaaki Matsuki1, 2, F. Hirose1, 2,
T. Kameda1, 2, Y. Hirami1, 2, Y. Kurimoto1, 2.
1
Ophthalmology, Kobe City Medical Center General
Hospital, Kobe, Japan; 2Ophthalmology, Inst of
Biomed Research and Innovation, Kobe, Japan *CR
4809 — D0248 Scan quality can affect
Scanning Laser Polarimetry outcomes. Alice
Chandra Verticchio Vercellin1, 2, G. Milano1, 2, S.
Lombardo1, 2, M. Raimondi1, 2, S. Lanteri1, 2, C.
Cutolo1, 2, L. Bossolesi2, 1, G. C. Rossi2, 1. 1University
of Pavia, Pavia, Italy; 2Policlinico San Matteo
Pavia, Pavia, Italy *CR
4810 — D0249 A New Marker for Detecting
Retinal Ganglion Cell Apoptosis. Jacky Man
Kwong Kwong1, C. Hoang1, R. M. Torrevillas1, J.
Caprioli1, R. W. Yee2, B. D. Gray3, J. A. Mattis3,
K. Y. Pak3. 1Ophthalmology, Jules Stein Eye
Institute, UCLA, Los Angeles, CA; 2Cizik Eye
Clinic, University of Texas, Health Science Center,
Houston, TX; 3Molecular Targeting Technologies,
Inc., West Chester, PA *CR
4812 — D0251 Effect of Laser Peripheral
Iridotomy on Trabecular-Iris Surface Area Over
360 Degrees in Primary Angle Closure. Donna
Nguyen1, N. P. Bell1, 2, L. S. Blieden1, 2, L. A. Baker2,
A. Z. Chuang1, R. M. Feldman1, 2. 1Ophthalmology
and Visual Science, The University of Texas Health
Science Center at Houston, Houston, TX; 2Robert
Cizik Eye Clinic, Houston, TX *CR
4813 — D0252 The Prevalence of Spectral
Domain Optical Coherence Tomography Artifact
Patterns in Different Subtypes of Open Angle
Glaucoma and Normal Eyes. Neda Baniasadi,
E. I. Paschalis, T. C. Chen. Ophthalmology,
Massachusetts Eye & Ear Infirmary/Harvard
Medical School, Boston, MA
4815 — D0254 A Novel Technology to Detect
and Visualize Macular Retinal Nerve Fiber
Layer (RNFL) Loss in Glaucoma Using Spectral
Domain Optical Coherence Tomography. Laura
de Polo1, 2, A. Invernizzi1, M. Cozzi1, M. Blini1, G.
Staurenghi1. 1Hospital Luigi Sacco, Milano, Italy;
2
COB,Centro Oculistico Bergamasco, Bergamo,
Italy *CR
4816 — D0255 In vivo imaging of lamina
cribrosa pore and optic nerve head geometry
in normal human eyes. Amitabha S. Bhakta, D.
J. Marrelli, N. Sredar, K. M. Ivers, N. B. Patel,
H. M. Queener, J. Porter. College of Optometry,
University of Houston, Houston, TX *CR
4817 — D0256 Frequency of Abnormal Retinal
Nerve Fiber Layer and Ganglion Cell Layer
SDOCT Scans in Healthy Eyes and Glaucoma
Suspects in a Prospective Longitudinal Study.
Shawn M. Iverson1, M. Sehi1, W. J. Feuer2, W.
Shi2, D. S. Greenfield1. 1Glaucoma, University of
Miami, Palm Beach Gardens, FL; 2Ophthalmology,
University of Miami, Miami, FL *CR, f
4818 — D0257 Inner Nuclear Layer (INL)
Cystoid Spaces (Lacunae) Observed in
Experimental Glaucoma and Axotomy in NonHuman Primates (NHPs). T Michael Nork1, 2,
C. A. Rasmussen1, 2, J. N. Ver Hoeve1, 2, C. J.
Murphy3, 2, M. W. Neider1, 2, C. B. Kim1, 2, B. J.
Christian4. 1Ophthal & Visual Sciences, Univ
of Wisconsin-Madison, Madison, WI; 2Ocular
Services On Demand (OSOD), LLC, Madison, WI;
3
Surgical Radiol Sci-Sch of Veterinary Medicine,
Univ California--Davis, Davis, CA; 4Covance, Inc,
Madison, WI *CR
4819 — D0258 Computational discovery of
optic nerve head phenotypes. Mark Christopher1,
L. Tang2, J. H. Fingert2, T. E. Scheetz2, 1, M. D.
Abramoff2, 3. 1Biomedical Engineering, University
of Iowa, Iowa City, IA; 2Ophthalmology and
Visual Sciences, University of Iowa, Iowa City, IA;
3
Veterans Affairs, University of Iowa, Iowa City,
IA *CR
4820 — D0259 The Effect of Image Quality
on the Reliability of Nerve Fiber Layer
Measurements with Fourier-Domain OCT. Ou
Tan1, X. Zhang1, N. A. Loewen2, J. S. Schuman2,
D. S. Greenfield3, R. Varma4, D. Huang1.
1
Ophthalmology, Oregon Health & Science Univ,
Portland, OR; 2Opthalmology, University of
Pittsburgh School of Medicine, Pittsburgh, PA;
3
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 4Ophthalmology, University of Southern
California and Doheny Eye Institute, Los Angeles,
CA *CR, f
4821 — D0260 Combining Optical Coherence
Topography measurements using the ‘Random
Forest’ decision tree classifier improves the
diagnosis of glaucoma. Koichiro Sugimoto, H.
Murata, H. Hirasawa, C. Mayama, M. Aihara, R.
Asaoka. Department of Ophthalmology, University
of Tokyo Graduate School of Medicine, Tokyo,
Japan *CR
4822 — D0261 Comparison of Gonioscopy
with Cirrus and Visante Optical Coherence
Tomography (OCT) for Anterior Chamber Angle
Assessment in Glaucoma Patients. Cindy X. Hu,
C. Zangalli, A. Mantravadi, M. Ali, B. M. Faria,
J. Richman, S. S. Wizov, R. Razeghinejad, M. R.
Moster, L. Katz. Glaucoma Research, Wills Eye
Institute, Philadelphia, PA *CR
4823 — D0262 In Vivo Structure of the
Schlemm’s Canal and the Collector Channels
in Eyes with Chronic Angle-Closure Glaucoma
Compared to Normal Eyes. Camila F. Netto1,
S. Park1, 2, W. A. Kirkland1, R. L. Furlanetto1, Y.
Liu1, 3, J. M. Liebmann1, 4, R. Ritch1, 2. 1Moise and
Chella Safra Advanced Ocular Imaging Laboratory,
Einhorn Clinical Research Center, New York Eye
and Ear Infirmary, New York, NY; 2Department
of Ophthalmology, New York Medical College,
Valhalla, NY; 3New York Medical College, Valhalla,
NY; 4Department of Ophthalmology, New York
University School of Medicine, New York, NY *CR
4824 — D0263 Stereo digital photography
demonstrates excellent reproducibility
with stereo slide film for the evaluation of
glaucomatous optic disc features. Faazil Kassam2,
S. Arora1, C. J. Rudnisky1, G. Douglas2, M. C.
Edwards1, K. Verstraten2, B. K. Wong3, K. F. Damji1.
1
Ophthalmology, University of Alberta, Edmonton,
AB, Canada; 2Ophthalmology, University of
Calgary, Calgary, AB, Canada; 3Ophthalmology,
Loma Linda University, Loma Linda, CA *CR
4825 — D0264 Comparison of Cirrus spectraldomain optical coherence tomography (OCT)
-measured macula ganglion cell-inner plexiform
layer (GCIPL) thickness and circumpapillary
retinal nerve fiber layer (cpRNFL) thicknessdeviation maps for detection of localized retinal
nerve fiber layer (RNFL) defects in glaucoma. Yu
Jeong Kim1, M. Kim1, 2, K. Park1, 2, J. Jeoung1, 2, Y.
Choi2, K. Kim2, D. Kim1, 2. 1Ophthalmology, Seoul
National University College of Medicine, Seoul,
Republic of Korea; 2Ophthalmology, Seoul National
University Hospital, Seoul, Republic of Korea
4826 — D0265 Does reduction in retinal nerve
fiber layer (RNFL) birefringence precede change
in RNFL thickness in glaucoma? Guihua Xu, Y.
Tse, C. K. Leung. The Chinese University of Hong
Kong, Hong Kong, China *CR
4827 — D0266 Glaucoma Clinician (GC)
Color Stereophoto (CSphoto) Rim Estimation
Compared to Colocalized Spectral Domain
Optical Coherence Tomography (SDOCT)
Minimum Rim Measurements. Robert M. Kinast,
R. Ren, H. Koenigsman, H. Yang, S. K. Gardiner, J.
Reynaud, S. L. Mansberger, B. Fortune, S. Demirel,
C. F. Burgoyne. Discoveries in Sight Research
Laboratories, Devers Eye Institute, Legacy
Research Institute, Portland, OR *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
309
Wednesday Posters
11:00 am – 12:45 pm
4811 — D0250 Pupil-based detection of
asymmetric glaucomatous damage - comparison
of the Konan RAPDx pupillograph, swinging
flashlight method, and magnifier-assisted
swinging flashlight method. Mohsin Ali1, 2, L. Lu1,
P. Martinez1, B. M. Faria1, L. Gupta1, A. Zhang1, 2,
E. Hwang1, M. R. Moster1, G. L. Spaeth1. 1Glaucoma
Service, Wills Eye Institute, Philadelphia, PA;
2
Jefferson Medical College, Philadelphia, PA *CR
4814 — D0253 Evaluation of segmented
macular scans by spectral domain optical
coherence tomography in glaucoma. Maxime
Delbarre, H. El Chehab, M. Francoz, J. Fenolland,
M. Marie, J. Giraud, F. May, J. G. Renard.
Department of Ophthalmology, Hopital du Val-deGrâce, Paris, France
4828 – 4849 – Wednesday – Posters
4828 — D0267 Ability of spectral domain
optical coherence tomography to diagnose
preperimetric glaucoma. Chandrasekhar
Garudadri, H. L. Rao, U. Addepalli, S. Chaudhary,
T. Kumbar, S. Senthil. Glaucoma, L V Prasad Eye
Institute, Hyderabad, India *CR
4835 — D0274 Association of vascular risk
factors with structural glaucomatous progression
by flicker chronoscopy. Margaret M. McGlynn,
J. R. Ehrlich, E. D. Marlow, F. Q. Silva, N. M.
Radcliffe. Weill Cornell Medical College, New
York, NY *CR
4829 — D0268 A novel alignment and
subtraction technique for the detection of
glaucoma progression. Elizabeth D. Marlow1, 2,
M. M. McGlynn2, N. M. Radcliffe2. 1New York
University School of Medicine, New York, NY;
2
Ophthalmology, Weill Cornell Medical College,
New York, NY *CR
4836 — D0275 Optic nerve head analysis using
confocal scanning laser ophthalmoscopy and
spectral-domain optical coherence tomography.
Gloria Roberti1, F. Oddone1, L. Tanga1, M.
Michelessi2, D. De Geronimo1, M. Centofanti1, 2, G.
Manni1, 2. 1IRCCS Fondazione GB Bietti, Rome,
Italy; 2DSCMT, University of Rome Tor Vergata,
Rome, Italy *CR
4830 — D0269 Glaucoma discrimination of
ganglion cell complex measurements with two
SD-OCT. Marlene Francoz, H. El Chehab, J.
Fenolland, M. Delbarre, J. Giraud, F. May, J. G.
Renard. Military Hosp of Val-de-Grace, Paris, Paris,
France
4831 — D0270 Enhanced Depth Imaging
Optical Coherence Tomography of Trabecular
Outflow Pathway. Anum Butt1, S. Park2, 3, R.
L. Furlanetto2, W. A. Kirkland2, C. F. Netto2,
M. Al-Jumayli2, J. M. Liebmann2, 4, R. Ritch2, 3.
1
Department of Ophthalmology, The Aga Khan
University, Karachi, Pakistan; 2Moise and Chella
Safra Advanced Ocular Imaging Laboratory,
Einhorn Clinical Research Center, New York Eye
and Ear Infirmary, New York, NY; 3Department
of Ophthalmology, New York Medical College,
Valhalla, NY; 4Department of Ophthalmology, New
York University School of Medicine, New York,
NY *CR
Wednesday Posters
11:00 am – 12:45 pm
4832 — D0271 Automated Flicker
Chronoscopy for the Identification of
Preperimetric Glaucomatous Progression.
Nathan M. Radcliffe, J. R. Ehrlich, F. Q. Silva,
Z. Syed. Ophthalmology, Weill Cornell Medical
College, New York, NY *CR
4833 — D0272 Developments in Optical
Coherence Tomography Imaging in a Rat
Model of Glaucoma. Jean-Remi Fenolland1, 2,
C. Boucher2, M. A. Mayer3, W. H. Rostene2, C.
Baudouin2, 4, A. Denoyer2, 4. 1Ophthalmology, Val
de Grace Military Hospital, Paris, France; 2Team
S12, Vision Institute, UPMC University Paris 6;
UMRS968 INSERM; UMR7210 CNRS, Paris,
France; 3Pattern Recognition Lab, University
of Erlangen-Nuremberg, Nuremberg, Germany;
4
Quinze-Vingts National Ophthalmology Hospital,
Paris, France
4834 — D0273 Optic disc and neuroretinal rim
area measurements with spectral-domain optical
coherence tomography and confocal scanning
laser ophthalmoscopy in myopic eyes. Kunliang
Qiu. JSIEC, Shantou, Afghanistan
4837 — D0276 A Tree Classification Method
for Identifying Normal Eyes, Non-Progressing
Glaucoma Eyes, and Progressing Glaucoma Eyes
from Spectral Domain OCT RNFL Thickness
Measurements. Michael H. Goldbaum, S. Yousefi,
A. Belghith, L. M. Zangwill, F. A. Medeiros, R. N.
Weinreb, D. Meira-Freitas, N. Hatami, C. Bowd.
Ophthalmology, University of California at San
Diego, La Jolla, CA *CR, f
4838 — D0277 Utilization of Novel Technology
to Improve Accuracy and Efficiency of Assessing
Progression of Glaucomautous Changes in
Serial Fundus Photos. Ozgur Ozkan1, R. Barnes2,
B. Markowitz1. 1Ophthalmology, University of
South Carolina/Palmetto Health, Columbia,
SC; 2Ophthalmology, Georgetown University/
Washington Hospital Center, Washington, DC *CR
4839 — D0278 Objective Assessment of
Glaucoma Suspect Comparing Different Imaging
Techniques. Eduardo M. Normando1, 2, L. A.
Turner1, F. Ahmed2, P. A. Bloom2, M. Cordeiro1, 2.
1
Glaucoma & Retinal Neurodegeneration Research
Group, Visual Neuroscience, UCL Institute of
Ophthalmology, London, United Kingdom;
2
Western Eye Hospital, Imperial College Healthcare
Trust, London, United Kingdom *CR
4840 — D0279 Evaluation of Inner to Outer
Retina Area Ratio for Detection of Glaucoma
with Macular OCT Imaging. Navid Amini1, 4, N.
Cirineo1, S. Knipping1, H. Hosseini1, J. A. Giaconi1,
S. K. Law1, T. Chou3, L. A. Vese2, J. Caprioli1,
K. Nouri-Mahdavi1. 1Ophthalmology, Jules
Stein Eye Institute at UCLA, Los Angeles, CA;
2
Department of Mathematics, UCLA, Los Angeles,
CA; 3Department of Biomathematics, UCLA, Los
Angeles, CA; 4UCLA Wireless Health Institute, Los
Angeles, CA *CR
4841 — D0280 The Magnitude and Direction of
Mismatch between Bruch’s Membrane Opening
(BMO) and Anterior Scleral Canal Opening
(ASCO) within Spectral Domain Optical
Coherence Tomography (SD-OCT) Optic Nerve
Head (ONH) Scans of Ocular Hypertension and
Glaucoma Patients. Christy A. Hardin, H. Yang, R.
Ren, L. He, S. K. Gardiner, B. Fortune, S. Demirel,
C. F. Burgoyne. Discoveries in Sight Research
Laboratory, Devers Eye Institution and Legacy
Research Institute, Porltand, OR *CR
4842 — D0281 Variability of the FovealBruch’s Membrane Opening centroid (FoBMO)
axis angle in patients with ocular hypertension
and early glaucoma. Luke Reyes, R. Ren, J.
Reynaud, H. Yang, S. K. Gardiner, B. Fortune,
S. Demirel, C. F. Burgoyne. Discoveries in Sight
Research Laboratories, Devers Eye Institute,
Legacy Research Institute, Portland, OR *CR
4843 — D0282 Quadratic Bayesian Pattern
Detection for Detecting Glaucomatous Change
in Follow-up SD-OCT RNFL Thickness
Measurements. Siamak Yousefi, A. Belghith, M.
H. Goldbaum, L. M. Zangwill, F. A. Medeiros, R.
N. Weinreb, R. Lisboa, C. Bowd. Ophthalmology,
Hamilton Glaucoma Center, La Jolla, CA *CR, f
4844 — D0283 A method for mapping retinal
nerve fiber layer birefringence. Juan Reynaud,
B. Fortune. Discoveries in Sight Research
Laboratories, Devers Eye Institute and Legacy
Research Institute, Portland, OR *CR
4845 — D0284 The Prevalence of Cirrus SDOCT Ganglion Cell Segmentation Errors in
High Myopes. Tessa Johung1, J. D. Oakley2, D.
Russakoff2, S. Sabhlok1, F. Li3, R. Chang1. 1Stanford
University, Stanford, CA; 2Voxeleron, Pleasanton,
CA; 3Dept. of Ophthalmology and Visual Sciences,
Chinese University of Hong Kong, Hong Kong,
China *CR
4846 — D0285 Optic disc morphology
parameters in primary open angle glaucoma in
Japanese using a stereo fundus camera - The
Glaucoma Stereo Analysis Study (GSAS). Yu
Yokoyama1, M. Tanito2, K. Nitta3, M. Katai4, Y.
Kitaoka5, K. Omodaka1, S. Tsuda1, T. Nakagawa6,
T. Nakazawa1. 1Department of Ophthalmology,
Tohoku university, Sendai-shi, Japan; 2Department
of Ophthalmology, Shimane University Faculty
of Medicine, Izumo-shi, Japan; 3Department of
Ophthalmology, Fukui-ken Saiseikai Hospital,
Fukui-shi, Japan; 4Department of Ophthalmology,
Sapporo Teishin Hospital, Sapporo-shi, Japan;
5
Department of Ophthalmology, St. Marianna
University School of Medicine, Sapporo-shi, Japan;
6
Research & Development Section, Electronics &
Optics Division, Kowa Company, Ltd, Nagoya-shi,
Japan *CR
4847 — D0286 Glaucoma Assessment using
Retinal Topography by Scanning Laser
Ophthalmoscope Imaging. Maarten Huijbregtse,
D. De Brouwere, M. Mensink. i-Optics BV, The
Hague, Netherlands *CR
4848 — D0287 Macular Retinal Ganglion
Cell Complex Thickness and Its Relationship
to the Retinal Nerve Fiber Layer in NonHuman Primates with Ocular Hypertension.
Kaveh Azartash, J. A. Burke. Biological Sciences,
Allergan, Irvine, CA *CR
4849 — D0288 Longitudinal Measurements
In Vivo of Retinal Nerve Fiber Layer Thickness
(RNFLT) and Retinal Ganglion Cell (RGC)
Density after Optic Nerve Transection (ONT)
in Rat. Tiffany E. Choe, C. J. Abbott, K. Young,
B. Fortune. Discoveries in Sight, Devers Eye Inst,
Legacy Health, Portland, OR *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
310
Wednesday – Posters – 4850 – 4871
4850 — D0289 In Vivo Dimensions of
Schlemm’s Canal and Number of Collector
Channels in the Nasal and Temporal Areas of
Normal Eyes. Wendy A. Kirkland1, S. Park1, 2,
R. L. Furlanetto1, C. F. Netto1, Y. Liu1, 3, J. M.
Liebmann1, 4, R. Ritch1, 2. 1Moise and Chella Safra
Advanced Ocular Imaging Laboratory, Einhorn
Clinical Research Center, New York Eye and
Ear Infirmary, New York, NY; 2Department
of Ophthalmology, Valhalla, NY; 3New York
Medical College, Valhalla, NY; 4Department of
Ophthalmology, New York University School of
Medicine, New York, NY *CR
4851 — D0290 The macular retinal layer
thickness in glaucoma patients. Yoshiaki Kiuchi,
U. Rimayanti, M. Latief. Ophthalmology & Visual
Science, Hiroshima University, Hiroshima, Japan
4852 — D0291 A comparison of retinal
nerve fiber layer quadrant thickness between
glaucomatous and glaucoma suspect eyes. Alicia
M. Eby, R. Momi, J. Tannir, B. A. Hughes, A. Goyal,
A. Shukairy, C. Kim, M. H. Peracha, F. Fatima,
M. McQueen. Kresge Eye Institute, Wayne State
University School of Medicine, Detroit, MI
Exhibit Hall D0292-D0309
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Multidisciplinary Ophthalmic Imaging
444 Choroid and Sclera Imaging
Moderator: Eric H. Souied
4853 — D0292 Effect of Acoustic Radiation
Force on the Retina, Choroid and Orbital
Tissues. Ronald H. Silverman1, 2, R. Urs1, H. Lloyd1.
1
Ophthalmology, Columbia University Medical
Center, New York, NY; 2FL Lizzi Center for
Biomedical Engineering, Riverside Research, New
York, NY
4855 — D0294 Pilot Study of the Topographic
Correlation Between Reticular Pseudo-drusen
and the Choroidal Vasculature Using En Face
Optical Coherence Tomography. Jonathan Chou,
S. D. Rollins, D. S. Grewal, S. Khan, A. A. Fawzi.
Ophthalmology, Northwestern University, Chicago,
IL
4856 — D0295 Choroidal Thickness in Adult
Onset Foveomacular Vittelliform Dystrophy and
in Exudative Age-related Macular Degeneration.
Florence Coscas, N. Puche, G. J. Coscas, C.
Francais, M. Srour, G. Mimoun, G. Querques, E.
H. Souied. Ophthalmology, University, Paris Est,
Creteil, France *CR
4858 — D0297 Enface Features of Chronic
Central Serous Chorioretinopathy on SweptSource Optical Coherence Tomography. Daniela
Ferrara1, 3, K. J. Mohler2, M. Adhi1, J. J. Liu2, I.
Grulkowski2, M. F. Kraus2, 4, N. K. Waheed1, C.
R. Baumal1, J. G. Fujimoto2, J. S. Duker1. 1New
England Eye Center, Tufts University, Boston,
MA; 2Department of Electrical Engineering and
Computer Science and Research Laboratory of
Electronics, Massachusetts Institute of Technology,
Cambridge, MA; 3Digital Angiography Reading
Center, New York, NY; 4Pattern Recognition
Lab and Graduate School in Advanced Optical
Technologies (SAOT), 4 University ErlangenNuremburg, Erlangen, Germany *CR
4859 — D0298 Evaluation of choroidal
thickness in retinal vein occlusions using
enhanced depth imaging optical coherence
tomography. Amar P. Patel, S. S. Park.
Ophthalmology, University of California, Davis,
Sacramento, CA
4860 — D0299 Diffuse choroidal thickening in
patients with Vogt-Koyanagi-Harada Syndrome.
Maria de las Mercedes Frick, M. Zunino, B. A.
Schlaen, M. Lopez, E. Hurtado Jallaza, C. A.
Couto. Ophthalmology, University of Buenos Aires,
Buenos Aires, Argentina
4861 — D0300 Punctate Inner Choroidopathy
characterization by Enhanced Depth ImagingOptical Coherence Tomography: Qualitative
analysis of PIC lesions & relationship with
clinical features. Raquel Garcia-Cabrera, J.
Zarranz-Ventura, D. A. Sim, P. A. Keane, C. A.
Egan, P. J. Patel, M. Westcott, R. W. Lee, A. Tufail,
C. E. Pavesio. Moorfields Eye Hospital, London,
United Kingdom *CR
4862 — D0301 The effect of scleral buckling
surgery on choroidal thickness measured
by enhanced depth optical coherence
tomography. Alla Kelly, D. D. Koozekanani,
J. Terry, S. R. Montezuma. Ophthalmology and
Visual Neurosciences, University of Minnesota,
Minneapolis, MN
4863 — D0302 Quantitative measurement of
laser-induced choroidal neovascularization with
spectral-domain optical coherent tomography.
Wenqiu Wang. Shanghai Key Lab of Ocular Fundus,
Shanghai First People’s Hospital, Shanghai, China
4864 — D0303 Peripapillary Choroidal
Thickness Analysis with Optical Coherence
Tomography in Unilateral Pseudoexfoliation
Glaucoma and Pseudoexfoliation Syndrome.
Claudia E. Bartolini, J. Zhang, M. Adhi, J. S. Duker,
C. Krishnan. Ophthalmology, New England Eye
Center/Tufts, Boston, MA *CR
4865 — D0304 Enhanced Depth Imaging
Optical Coherence Tomography of Choroidal
Metastasis in 31 Eyes. SAAD AL-DAHMASH1, 2,
C. L. Shields2, S. Kaliki2, T. V. Johnson2, J.
Shields2. 1King Saud University, Riyadh, Saudi
Arabia; 2Oncology Service, Wills Eye Institute,
Philadelphia, PA
4866 — D0305 The comparison between
subfoveal choroidal thickness measured with two
different SD-OCT. Yuki Maekawa, K. Suzuma, E.
Tsuiki, T. Kitaoka. Department of Ophthalmology
& Visual Sciences, Nagasaki University Graduate
School of Biomedical Sciences, Nagasaki, Japan
4867 — D0306 Comparison of the Accuracy of
Choroidal Thickness Measurements Using SDOCT With and Without EDI and Swept Source
OCT and Volumetric Analysis of the Choroid
in Healthy Eyes. Mehreen Adhi1, 2, J. J. Liu3, A.
H. Qavi1, I. Grulkowski3, K. J. Mohler3, C. D. Lu3,
M. F. Kraus3, N. K. Waheed1, 2, J. G. Fujimoto3,
J. S. Duker1, 2. 1Ophthalmology, New England
Eye Center, Tufts Medical Center, Boston, MA;
2
Ophthalmology, Tufts Univ School of Medicine,
Boston, MA; 3Research Laboratory of Electronics,
Massachusetts Institute of Technology, Cambridge,
MA *CR
4868 — D0307 Optovue OCT as an Imaging
Modality for Scleral Thickness. Stephanie K.
Cramer, R. M. Beardsley, C. J. Flaxel, E. B. Suhler,
N. S. Schubach. Ophthalmology, Casey Eye
Institute, Portland, OR *CR
4869 — D0308 Choroidal thickness in
emmetropic and myopic children and adults, and
myopic anisometropes. Andrew K. Lam, Y. Wong,
B. S. Yu. School of Optometry, The Hong Kong
Polytechnic University, Hong Kong, Hong Kong
4870 — D0309 Choroidal Volume in Healthy
Pediatric Population. Chiara Mapelli1, 2,
E. Tabacchi2, S. Osnaghi2, L. Dell’Arti1, 2, G.
Barteselli1, M. Clerici1, F. Viola1, 2, R. Ratiglia1, 2.
1
University of Milan, Milan, Italy; 2Eye Clinic,
Fondazione IRCCS Ca’ Granda Ospedale
Policlinico, Milan, Italy
Exhibit Hall D0310-D0336
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Multidisciplinary Ophthalmic Imaging
445 Imaging of Animal Models
Moderator: Mahnaz Shahidi
4871 — D0310 Quantitative Fundus
Autofluorescence in Mice. Correlation with
HPLC Quantitation of RPE Lipofuscin and
Measurement of Retina Outer Nuclear Layer
Thickness. Janet R. Sparrow1, 2, A. M. Blonska1,
E. Flynn1, T. Duncker1, J. P. Greenberg1, R.
Secondi1, K. Ueda1, F. C. Delori3. 1Department
of Ophthalmology, Columbia University, New
York, NY; 2Pathology and Cell Biology, Columbia
University, New York, NY; 3Schepens Eye Research
Institute, Harvard Medical School, Boston, MA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
311
Wednesday Posters
11:00 am – 12:45 pm
4854 — D0293 Analysis of the Vascular Layers
and Morphology of the Choroid in Eyes with
Diabetic Retinopathy using Spectral-Domain
Optical Coherence Tomography. Erika Brewer1, 2,
M. Adhi1, 2, N. K. Waheed1, 2, J. S. Duker1, 2. 1New
England Eye Center, Boston, MA; 2Tufts University
School of Medicine, Boston, MA *CR
4857 — D0296 Differences in subfoveal
choroidal thickness between acute and chronic
central serous chorioretinopathy measured with
enhanced depth imaging OCT. Nikolaus Feucht,
C. Lohmann, P. Kook, C. Mayer, M. Zenk, K. M.
Wand, M. M. Maier. Ophthalmology, Klinikum
rechts der Isar, Technische Universität München,
Munich, Germany *CR
4872 – 4892 – Wednesday – Posters
4872 — D0311 In Vivo Imaging of hESC-RPE
Implanted in the RCS Rat Using InfraRed
Reflectance. Aldo A. Oregon-Miranda1, 2, R.
Ribeiro1, W. Charafeddin1, B. Diniz1, M. J. Koss1,
P. B. Thomas1, B. B. Thomas1, G. J. Chader1,
D. R. Hinton1, M. S. Humayun1. 1Doheny eye
institute, University of Southern California, Los
Angeles, CA; 2Oftalmologia, Antiguo Hospital
Civil de Guadalajara, Fray Antonio Alcalde, UDG,
Guadalajara, Mexico *CR
4873 — D0312 Spectral Domain Optical
Coherence Tomography as a Measure of Axonal
Degeneration and Protection in Experimental
Autoimmune Encephalomyelitis. Anastasiya
Johnson1, K. V. Michaels1, B. K. Morris2, A. K.
Garg1, P. Chaudhary2, H. E. Titus1, M. D. Andrews1,
D. Bourdette2, M. E. Pennesi1, G. H. Marracci2.
1
Ophthalmology, Oregon Health & Science
Institute, Portland, OR; 2Neurology, Oregon Health
& Science University, Portland, OR *CR
4874 — D0313 Comparison of ocular
parameters of Bugeye and Wild-type zebrafish
using Optical Coherence Tomography. Pinakin G.
Davey, D. Cameron. College of Optometry, Western
University of Health Sciences, Pomona, CA
4875 — D0314 Multimodal adaptive optics
imaging system (MAOS) for small animals. Ankit
Patel1, R. D. Ferguson1, M. Mujat1, N. Iftimia1, J.
D. Akula2. 1Biomedical Imaging Group, Physical
Sciences Inc, Andover, MA; 2Ophthalmology,
Children’s Hospital Boston, Boston, MA *CR
Wednesday Posters
11:00 am – 12:45 pm
4876 — D0315 Assessment of Vascular
Integrity and Leukocyte Endothelial Interaction
in the Murine Retina After Ionizing Radiation
by in vivo retinal imaging. Clemens Alt, J. M.
Runnels, G. Teo, C. P. Lin. Wellman Center for
Photomedicine, Massachusetts General Hospital,
Boston, MA
4877 — D0316 Fluorescence lifetime imaging in
mouse models. Chantal Dysli, V. Enzmann, S. Wolf,
M. S. Zinkernagel. University of Bern, Department
of Ophthalmology, Bern, Switzerland *CR
4878 — D0317 Density and distribution of
NG2+ pericytes in the living mouse retina.
HoanVu Nguyen1, D. R. Williams2, 3, J. B. Schallek2.
1
Department of Biological Sciences, University of
Denver, Denver, CO; 2Center for Visual Science,
University of Rochester, Rochester, NY; 3The
Institute of Optics, University of Rochester,
Rochester, NY *CR
4879 — D0318 A Novel Rodent Model of
Retinal Edema. Xin Xia1, 2, M. Zheng1, R. Wen3, W.
Chen1, Q. Gu1, 2. 1Shanghai First People’s Hospital,
Shanghai Jiao Tong University, Shanghai, China;
2
Shanghai Key Laboratory for Ocular Fundus
Diseases, Shanghai, China; 3Bascom Palmer Eye
Institute, University of Miami, Miami, FL *CR
4880 — D0319 Single- and multi-photon
fluorescence retinal imaging in the intact rodent
eye: a comparison. Adi Schejter, N. Farah, L. Tsur,
S. Shoham. Biomedical Engineering, Technion,
Haifa, Israel
4881 — D0320 Retinal intrinsic optical signals
in rabbits. Azadeh Naderian1, 2, L. Bussieres1, S.
Thomas1, F. Lesage2, C. Casanova1. 1University
of Montreal, montreal, QC, Canada; 2Ecole
Polytechnique, montreal, QC, Canada *CR
4882 — D0321 Contrast-enhanced MRI
of Brain Abnormalities and Cerebrospinal
Fluid (CSF) Buildup in CEP290 Knockout
(ko) Mice: Effect of Ciliogenesis on Volumetry
of CSF, Cerebrum and Cerebellum. Mrinal
K. Dewanjee, R. A. Rachel, E. Yamamoto, J. P.
Munasinghe, L. Dong, A. Swaroop. NeurobiologyNeurodegeneration & Repair, National Eye
Institute, Bethesda, MD
4883 — D0322 Retinal thickness changes
in mice with streptozotocin-induced diabetes
mellitus quantified using an enhanced Iowa
Reference Algorithm. Woo Jin Jeong1, 2, M. D.
Abramoff1, 3, B. J. Antony4, C. Jiao1, M. K. Garvin3, 5,
E. H. Sohn1. 1Institute for Vision Research,
Ophthalmology and Visual Sciences, University
of Iowa, Iowa city, IA; 2Ophthalmology, Dong-A
University College of Medicine and Medical
Science Research Center, busan, Republic of Korea;
3
Iowa Institute for Biomedical Imaging, University
of Iowa, Iowa city, IA; 4Department of Electrical
and Computer Engineering, Iowa city, IA; 5VA
Medical Center, Iowa city, IA *CR
4884 — D0323 Application of phase variance
optical coherence tomography for in-vivo
imaging of retinal micro-vasculature in mice.
Robert J. Zawadzki1, 2, Y. Jian3, M. V. Sarunic3, J. S.
Werner2, 4, E. N. Pugh1, 5. 1Cell Biology and Human
Anatomy, Univerisy of California Davis, Davis,
CA; 2Ophthalmology & Vision Science, University
of California Davis, Sacramento, CA; 3Engineering
Science, Simon Fraser University, Burnaby, BC,
Canada; 4Neurobiology, Physiology, and Behavior,
Univeristy of California Davis, Davis, CA;
5
Physiology and Membrane Biology, Univeristy of
California Davis, Davis, CA
4885 — D0324 Correcting Lateral
Magnification in OCT Imaging of the Rat Eye.
Diana C. Lozano, M. D. Twa. College of Optometry,
University of Houston, Houston, TX
4886 — D0325 Inner Retinal Oxygen
Metabolism and Delivery in Streptozotocin
Diabetic Rats. Justin Wanek, P. Teng, N. P. Blair,
M. Shahidi. Ophthalmology and Visual Sciences,
University of Illinois at Chicago, Chicago, IL *CR
4887 — D0326 In vivo imaging of a new
indocyanine green micelle formulation in an
animal model. Steffen Schmitz-Valckenberg1, J.
Meyer1, A. R. Cunea1, P. Welker2, K. Licha2, D.
Sonntag-Bensch1, F. G. Holz1. 1Ophthalmology,
University of Bonn, Bonn, Germany; 2mivenion
GmbH, Berlin, Germany *CR
4889 — D0328 Functional imaging of retina
in response to defocused grating light stimuli in
cats. Yoko Hirohara1, 2, T. Mihashi3, 2, H. Kanda2,
T. Miyoshi4, T. Morimoto5, J. S. Wolffsohn6, T.
Fujikado2. 1Optical Engineering Laboratory, Topcon
Corporation, Itabashi-ku, Japan; 2Department
of Applied Visual Science, Osaka University
Graduate School of Medicine, Suita, Japan;
3
Innovative Research Initiatives, Tokyo Institute
of Technology, Yokohama, Japan; 4Department of
Integrative Physiology, Osaka University Graduate
School of Medicine, Suita, Japan; 5Department of
Ophthalmology, Osaka University Graduate School
of Medicine, Suita, Japan; 6and Health Science,
Aston University, Birmingham, United Kingdom
*CR
4890 — D0329 Peripapillary Rat Sclera
Investigated Using Polarization Sensitive
Optical Coherence Tomography Imaging and
Histological Analysis. Bernhard Baumann1,
S. Rauscher2, M. Glösmann3, M. Bonesi1, E.
Gotzinger1, M. Pircher1, H. Sattmann1, S. Zotter1,
T. Torzicky1, C. K. Hitzenberger1. 1Ctr for Med
Physics & Biomed Engineering, Medical University
of Vienna, Vienna, Austria; 2Core Facility Imaging,
Medical University of Vienna, Vienna, Austria;
3
Core Facility for Research and Technology,
University of Veterinary Medicine Vienna, Vienna,
Austria *CR
4891 — D0330 Pharmacokinetics of I-124
aflibercept after intravitreal injection using
PET/CT imaging after lensectomy in a rabbit
model. John B. Christoforidis1, M. M. Williams2,
F. M. Epitropoulos3, M. V. Knopp2. 1Department
of Ophthalmology and Vision Science, University
of Arizona College of Medicine, Tucson, AZ;
2
Radiology, The Ohio State University College
of Medicine, Columbus, OH; 3Ophthalmology,
The Ohio State University College of Medicine,
Columbus, OH
4892 — D0331 Segmentation of Multiple
Intra-retinal Surfaces in Volumetric SD-OCT
Images of Mouse Eyes Using an Improved
Iowa Reference Algorithm. Bhavna J. Antony1, 3,
M. D. Abramoff2, 3, W. Jeong4, E. H. Sohn4, M. K.
Garvin3, 1. 1Department of Electrical and Computer
Engineering, The University of Iowa, Iowa City,
IA; 2Department of Ophthalmology and Visual
Sciences, The University of Iowa, Iowa City, IA;
3
Center for the Prevention and Treatment of Visual
Loss, VA Health Care System, Iowa City, IA;
4
Institute of Vision Research, Ophthalmology and
Visual Sciences, The University of Iowa, Iowa City,
IA *CR
4888 — D0327 Retinal OCT Reflectivity
Profiles In Three Laboratory Animal Species.
Marina Garcia Garrido1, C. Seide1, V. Sothilingam1,
S. Julien2, U. Schraermeyer2, N. Tanimoto1, M. W.
Seeliger1. 1Division of Ocular Neurodegeneration,
Ctr Ophthal Inst Ophthalmic Resrch, Tuebingen,
Germany; 2Section of Experimental Vitreoretinal
Surgery, Ctr Ophthal Inst Ophthalmic Resrch,
Tuebingen, Germany *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
312
Wednesday – Posters – 4893 – 4913
4893 — D0332 Spectral-Domain Optical
Coherence Tomography of the Optic Nerve
Head in a Canine Model of Primary Open-Angle
Glaucoma. Annie Oh1, 2, C. Harman1, K. L. Koehl1,
J. Huang3, L. B. Teixeira4, L. M. Occelli1, E. Storey5,
G. Ying3, A. M. Komaromy1, 6. 1College of Veterinary
Medicine, Michigan State University, East Lansing,
MI; 2College of Veterinary Medicine, Western
University of Health Sciences, Pomona, CA;
3
Scheie Eye Institute, University of Pennsylvania,
Philadelphia, PA; 4School of Veterinary Medicine,
University of Wisconsin-Madison, Madison, WI;
5
School of Veterinary Medicine, Louisiana State
University, Baton Rouge, LA; 6School of Veterinary
Medicine, University of Pennsylvania, Philadelphia,
PA
4894 — D0333 Imaging Functional Hyperemia
in Response to Flicker Stimulus in the Rat
Retina Using Ultrahigh-Speed Spectral / Fourier
Domain OCT. WooJhon Choi1, A. Clermont2, E.
P. Feener2, D. Boas3, J. G. Fujimoto1. 1Electrical
Engineering, Massachusetts Institute of Technology,
Cambridge, MA; 2Beetham Eye Institute, Joslin
Diabetes Center, Boston, MA; 3Athinoula
A. Martinos Center for Biomedical Imaging,
Massachusetts General Hospital, Charlestown, MA
*CR
4895 — D0334 Dynamics of Retinal Pathology
in BALB/cJ Mice Housed in Cyclic Light
Conditions: An Imaging Study to Elucidate
Changes Induced by Long Term Exposure. Brent
A. Bell1, C. A. Kaul1, I. S. Samuels1, 2, V. L. Bonilha1,
M. E. Rayborn1, J. G. Hollyfield1, 3. 1Department of
Ophthalmic Research, Cole Eye Institute, Cleveland
Clinic, Cleveland, OH; 2Research Service, Louis
Stokes Cleveland VA Medical Center, Cleveland,
OH; 3Department of Ophthalmology, Cleveland
Clinic Lerner College of Medicine at Case Western
Reserve University, Cleveland, OH
4897 — D0336 Development of a Rat Model for
Retrobulbar Angiography of X-Ray Computed
Tomography with an Iodine-Containing Polymer.
Kenji Matsushita, R. Kawashima, S. Usui, K.
Nishida. Ophthalmology, Osaka University Medical
School, Suita, Japan *CR
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Retina
446 Imaging I, RE
Moderators: Michael D. Abramoff, Cynthia A.
Toth and Camiel J. Boon
4898 — D0337 Qualitative and quantitative
changes of cystoid macular edema treated with
Ozurdex therapy. Raeba Mathew1, E. Pearce1, 2,
S. Sivaprasad2, 1. 1Ophthalmology, King’s College
Hospital, London, London, United Kingdom;
2
Ophthalmology, Moorfields Eye Hospital, London,
United Kingdom *CR, f
4899 — D0338 Retinal Blood Flow Velocities
in Patients with Retinal Vein Occlusion. Gennady
Landa, N. K. Scripsema, R. B. Rosen. Department of
Ophthalmology, New York Eye and Ear Infirmary,
New York, NY *CR
4900 — D0339 Prediction of visual prognosis
with spectral domain optical coherence
tomography in outer retinal atrophy secondary
to closed-globe trauma. Haoyu Chen, Y. Lu, H.
Huang, J. Zheng, P. Hou, W. Chen. Joint Shantou
International Eye Center, Shantou, China
4901 — D0340 Automated Detection and
Location Analysis of Diabetic Cysts in Retinal
OCT Images: An Iterative Filtering Approach.
Sohini RoyChowdhury1, D. D. Koozekanani2, S.
Radwan2, 3, K. K. Parhi1. 1Electrical Engineering,
University of Minnesota, Minneapolis, MN;
2
Department of Ophthalmology, University of
Minnesota, Mineapolis, MN; 3Ophthalmology,
Cairo University, Cairo, Egypt *CR
4902 — D0341 Evaluation Of Functional
And Morphological Parameters In Patients
With RVO Treated With Intravitreal Steroid
Implant. Simone Donati, E. Melardi, M. Al
Oum, C. Gandolfi, M. Bianchi, R. Vinciguerra, C.
Azzolini. Department of Morphological and Surgical
Sciences, University of Insubria-Circolo Hospital,
Varese, Italy
4903 — D0342 Macular Thickness Evaluation
in Young Patients With Type 1 Diabetes Mellitus
and Healthy Controls. Muna Al Oum1, S. Donati1,
C. Gandolfi1, L. Premoli1, M. Chiaravalli1, M.
Marazza2, A. Salvatoni2, C. Azzolini1. 1Department
of Surgical and Morphological Science,
University of Insubria-Circolo Hospital, Varese,
Italy; 2Department of Clinical and Experimental
Medicine, University of Insubria-Del Ponte
Hospital, Varese, Italy
4904 — D0343 Yearly Loss of Retinal
Thickness and Macular Volume Estimated from
SPECTRALIS OCT Measurements in Patients
with Stargardt Macular Dystrophy. Rupert W.
Strauss1, 2, E. Fletcher1, 3, Y. Wolfson1, H. P. Scholl1.
1
Wilmer Eye Institute, Johns Hopkins University,
Baltimore, MD; 2Dept. of Ophthalmology,
Medical University Graz, Graz, Austria; 3Dept. of
Ophthalmology, Cheltenham General Hospital,
Gloucestershire Hospitals NHS Foundation Trust,
Cheltenham, United Kingdom
4905 — D0344 Choroidal Thickness in Healthy
Pregnant Women Using EDI-OCT. Eric K. Chin,
K. V. Lam, K. Chandra, E. F. Redenbo, S. S. Park.
Ophthalmology, UC Davis Eye Center, Sacramento,
CA
4906 — D0345 Prevalence Of Epiretinal
Membrane In Eyes That Underwent Scleral
Buckle Surgery For Repair Of Primary
Rhegmatogenous Retinal Detachment When
Imaged By SD-OCT. Rosa E. Martinez-Munoz, J.
J. Fromow-Guerra, V. Morales-Canton, V. FrancoCardenas. Retina and Vitreous, Asociacion Para
Evitar la Ceguera en Mexico, Mexico, Mexico *CR
4907 — D0346 Clinical Feasibility and
Utility of Ultra Wide-Field Indocyanine
Green Angiography. Thomas L. Berenberg1, S.
D. Bhaleeya1, M. M. Wessel1, M. T. Witmer1, S.
Patel1, S. R. Sadda2, S. Kiss1. 1Ophthalmology,
Weill Cornell Medical College, New York, NY;
2
Ophthalmology, USC Doheny Eye Institute, Los
Angeles, CA *CR
4908 — D0347 Correlation of Posterior
Inflammatory Leakage and Cystoid Macular
Edema with Retinal Pigment Epithelium
Atrophy in Retinitis Pigmentosa Evaluated
with Optos Wide-field Fluorescein Angiography
and Spectral Domain OCT. Carlos A. MedinaMendez, M. B. Kaufman, A. W. Eller, T. R. Friberg.
Ophthalmology, University of Pittsburgh Medical
Center, Pittsburgh, PA *CR
4909 — D0348 Correlation between
Visual Acuity and Spectral Domain Optical
Coherence Tomography Findings in Birdshot
Chorioretinopathy Patients. Vincent Y. Ho1,
J. Shantha1, F. Forooghian2, C. Bergstrom1, G.
B. Hubbard1, T. W. Olsen1, P. Patel1, S. Yeh1.
1
Ophthalmology, Emory Eye Center, Atlanta, GA;
2
Ophthalmology, St. Paul’s Hospital, Vancouver,
BC, Canada *CR
4910 — D0349 Comparison of Optical
Coherence Tomography Scan Patterns and
Clinical Review Strategies in the Management of
Neovascular Age-related Macular Degeneration.
Robert J. Courtney, J. McClintic, J. P. Ehlers.
Ophthalmology, Cole Eye Institute, Cleveland
Clinic Foundation, Cleveland, OH *CR
4911 — D0350 Perivascular fundus
autofluorescence abnormalities in autoimmune
retinopathy. Damien C. Rodger, G. M. Richter, H.
Nazari Khanamiri, N. A. Rao. Doheny Eye Institute,
Los Angeles, CA
4912 — D0351 The clinical and spectraldomain optical coherence tomography findings
in focal choroidal excavation. Christopher S.
Lee1, S. Woo2, D. Hwang2, S. lee1. 1Ophthalmology,
Yonsei Univ College of Medicine, Seoul, Republic
of Korea; 2Ophthalmology, Seoul National Univ
College of Medicine, Seoul, Republic of Korea
4913 — D0352 Wide field imaging in
Coat‘s disease. Carl F. Arndt, S. Masse, K.
Vardi, A. Ducasse, O. Zambrowski. Service
d’Ophthalmologie, Reims University Hospital,
Reims, France *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
313
Wednesday Posters
11:00 am – 12:45 pm
4896 — D0335 Microstructural and
physiological alterations in hypoxic-ischemicinjured visual system. Swarupa Kancherla1, K. C.
Chan1, 2. 1UPMC Eye Center, Eye and Ear Institute,
Ophthalmology and Visual Science Research
Center, Department of Ophthalmology, University
of Pittsburgh, Pittsburgh, PA; 2Department
of Bioengineering, University of Pittsburgh,
Pittsburgh, PA
Exhibit Hall D0337-D0355
4914 – 4934 – Wednesday – Posters
4914 — D0353 Reproducibility and
Agreeability of Automated Retinal
Pigment Epithelial Detachment Volumetric
Measurements via Spectral Domain Optical
Coherence Tomography. Joseph Ho1, M. Adhi1, E.
Cole1, J. J. Liu2, J. G. Fujimoto2, J. S. Duker1, N.
K. Waheed1. 1Department of Ophthalmology, TuftsNew England Eye Center, Boston, MA; 2Research
Laboratory of Electronics, Massachusetts Institute
of Technology, Cambridge, MA *CR
4915 — D0354 Use of SD-OCT/SLO as an
alternative to ultrasonography to monitor
patients with recurrent retinal detachments
and silicone oil tamponade. Jessica N. Taibl1, 2,
S. I. Sayegh1. 1The EYE Center, Champaign, IL;
2
University of Illinois, Urbana-Champaign, IL
4916 — D0355 Long-term changes of
fudus autofluorescence in central serous
chorioretinopathy. Tetsuju Sekiryu, H. Oyamada,
K. Imaizumi, T. Mori, I. Maruko. Ophthalmology,
Fukushima Medical University, Fukushima, Japan
Exhibit Hall D0356-D0376
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Retina
447 DME: OCT and Function
Moderators: Masahiko Shimura and
Francesco Bandello
Wednesday Posters
11:00 am – 12:45 pm
4917 — D0356 Correlations between Retinal
Morphological Changes and Concentrations of
Cytokines in Eyes with Diabetic Macular Edema.
Shozo Sonoda, T. Yamashita, M. Shirasawa, H.
Otsuka, Y. Sonoda, T. Sakamoto. Department of
Ophthalmology, Kagoshima University, Kagoshima,
Japan
4918 — D0357 Correlation between Diabetic
Macular Edema (DME) and extraocular
complications observed during diabetes.
Olivier Lichtwitz1, N. Leveziel1, M. Boissonnot1,
A. Miot2, X. Piguel2, F. Torremocha2, P. Saulnier3,
R. Maréchaud2, S. Hadjadj2. 1Ophthalmology,
Hospital University of Poitiers, Poitiers, France;
2
Endocrinollogy, Hospital University of Poitiers,
Poitiers, France; 3Center of Clinical Investigation,
INSERM CIC 802, Poitiers, France *CR
4919 — D0358 Evaluation of choroidal
thickness by enhanced depth imaging OCT in
the LUCIDATE study: a randomised clinical
trial to compare outcomes of ranibizumab
with laser in diabetic macular oedema. Rishma
Gohil1, 2, O. Comyn1, P. A. Keane1, P. J. Patel1, J. W.
Bainbridge1, S. Sivaprasad1, 2, P. G. Hykin1. 1NIHR
Biomedical Research Centre at Moorfields Eye
Hospital NHS Foundation Trust and UCL Institute
of Ophthalmology, London, United Kingdom;
2
King’s College London, London, United Kingdom
*CR, f
4920 — D0359 Chromatic sensitivity in
diabetic patients treated with Ozurdex. Ahmed
F. Abdel-hay1, 2, S. Sivaprasad1, A. Subramanian2,
E. Konstantakopoulou2, D. F. Edgar2, J. L. Barbur2.
1
Ophthalmology, King’s College Hospital, London,
United Kingdom; 21Applied Vision Research
Centre, City University London, London, United
Kingdom *CR, f
4921 — D0360 Longitudinal Comparison of
Visual Acuity as Measured by ETDRS Chart and
by Potential Acuity Meter in Eyes with Macular
Edema and Its Relationship with Macular
Sensitivity and Thickness. Elham Hatef Naimi1, 2,
M. Hanout1, O. O. Agbedia1, A. Moradi1, D. V.
Do1, D. L. Guyton1, Q. Nguyen1. 1Ophthalmology,
Wilmer Eye Inst, Johns Hopkins Univ, Baltimore,
MD; 2General Preventive Medicine, Johns Hopkins
Bloomberg School of Public Health, Baltimore,
MD *CR
4922 — D0361 Retinal Perifoveal Inner
Layer Disorganization as a Predictor of Visual
Acuity Outcomes in Eyes with Center-involved
Diabetic Macular Edema. Michael M. Lin1, 7, R.
Sarangi1, 2, J. Lammer1, 3, A. Y. Ganjei1, S. Radwan4,
5
, A. Z. Soliman4, 5, P. S. Silva1, 6, L. P. Aiello1,
6
, J. K. Sun1, 6. 1Beetham Eye Institute, Joslin
Diabetes Center, Boston, MA; 2Boston University
School of Medicine, Boston, MA; 3Department
of Ophthalmology and Optometry, Medical
University Vienna, Vienna, Austria; 4Department
of Ophthalmology, University of Minnesota,
Minneapolis, MN; 5Department of Ophthalmology,
Cairo University, Cairo, Egypt; 6Department of
Ophthalmology, Harvard Medical School, Boston,
MA; 7Harvard Medical School, Boston, MA *CR
4923 — D0362 The effect of hard exudates
and epiretinal fibrosis on the retinal thickness
as calculated by optical coherence tomography
(OCT) in diabetic macular edema. Delila Hodzic1,
B. A. Sander1, H. Lund-Andersen1, 2. 1Department
of ophthalmology, Glostrup Hospital, Glostrup,
Denmark; 2Faculty of Health Sciences, University
of Copenhagen, Copenhagen, Denmark
4924 — D0363 Correlation of structural and
visual function tests in patients with diabetic
macular edema. Elizabeth Pearce, R. Mathew, A.
F. Abdel-hay, S. Sivaprasad. Ophthalmology, King’s
College Hospital, London, United Kingdom *CR, f
4925 — D0364 Retinal Layer Thicknesses
in SDOCT Images for Diabetics with Hard
Exudates. Joel A. Papay1, A. E. Elsner1, C. A.
Clark1, V. Malinovsky1, S. G. Brahm1, S. B. Young1,
A. V. Walker1, T. V. Litvin2, G. Y. Ozawa2, J. A.
Cuadros2. 1School of Optometry, Indiana University,
Bloomington, IN; 2School of Optometry, UC
Berkeley, Berkeley, CA *CR
4926 — D0365 Retinal thickness reduction
and layers involvement in different diseases
visualized by SD-OCT. Michele M. Iester1, L.
Borgia2. 1DiNOGMI, University of Genoa, Genova,
Italy; 2Is.Pre Oftalmica, Genoa, Italy
4927 — D0366 Visual acuity evaluation in
patients treated with ranibizumab for diabetic
macular edema. Marc Stahel1, P. P. Ciechanowski1,
F. Moser1, S. Lortz1, H. M. Fassnacht1, N. T. Graf2,
M. D. Becker1, S. Michels1. 1Ophthalmology,
Triemli Hospital Zurich, Zurich, Switzerland; 2Graf
Biostatistics, Winterthur, Switzerland *CR
4928 — D0367 Differences in the topographic
profile of retinal thickening in cases of diabetic
macular edema with and without serous
macular detachment. Hannah Shereef1, 4, O.
Comyn2, S. Sivaprasad2, P. G. Hykin2, G. C.
Cheung3, N. Narendran4, Y. C. Yang4. 1University
of Birmingham, Birmingham, United Kingdom;
2
National Institute for Health Research Biomedical
Research Centre at Moorfields Eye Hospital
NHS Foundation Trust and UCL Institute of
Ophthalmology, London, United Kingdom;
3
Singapore National Eye Centre, Singapore,
Singapore; 4Royal Wolverhampton Hospitals NHS
Trust, Wolverhampton, United Kingdom *CR
4929 — D0368 Use of a Retinal Acuity Meter
(RAM) and Brightness Acuity Meter (BAM) to
Identify Early Diabetic Macular Edema. Albert
Li, D. J. Sackel, A. Chen, L. Park. Ophthalmology,
NYU School of Medicine, New York, NY
4930 — D0369 Optimal treatment strategy
for Stage 5 Type 2A Idiopathic Macular
Telangiectasia with anti-vascular endothelial
growth factor (VEGF) agents - When to stop?
Sharad S. Malavade, S. Cohen. Ophthalmology,
University of South Florida, Tampa, FL
4931 — D0370 Safety, sterility and stability of
direct- from- vial multiple dosing intravitreal
injection of bevacizumab. Taraprasad Das1, S.
Volety2, S. M. Ahsan2, A. K. Thakur2, S. Sharma1,
S. Basu1, T. R. Padhi1, M. Rao2. 1Retina Vitreous
Services, LV Prasad Eye Institute, Bhubaneswar,
India; 2Center for Cellular and Molecular Biology,
Hyderabad, India
4932 — D0371 Increased Healthcare Cost
Related To Adding Dexamethasone Implant
(Ozurdex®) To Bevacizumab (Avastin®)
Monotherapy In Patients With Cystoid Macular
Edema (CME) Due To Retinal Vein Occlusion
(RVO) May Be Balanced By Less Frequent
Follow-Up. Omar Saleh, J. Heroman, S. Schaal.
University of Louisville, Louisville, KY
4933 — D0372 Reperfusion of ischemia with
central retinal vein occlusion by activated
protein C. Motohiro Kamei, N. Matsumura, M.
Suzuki, S. Sakimoto, H. Sakaguchi, K. Nishida.
Ophthalmology, Osaka Univ Grad School of
Medicine, Suita, Japan *CR, f
4934 — D0373 The Efficacy of Single
Intravitreal Ranibizumab Injection in Acute
Nonarteritic Ischemic Optic Neuropathy. Ali
Osman Saatci, O. Taskin, O. Barut Selver, A. Yaman,
M. Soylev Bajin. Ophthalmology Department,
Dokuz Eylul University, Izmir, Turkey
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
314
Wednesday – Posters – 4935 – 4937
4935 — D0374 Influence of Axial Length
and Degree of Injection Reflux on Sustained
Intraocular Pressure Elevation Due to
Intravitreal Anti-Vascular Endothelial
Growth Factor Therapy. Luis Mendonca1, 2, Q.
V. Hoang2, 3, J. J. Jung4, S. Mrejen2, K. Freund2,
3 1
. Ophthalmology, Hospital de Braga, Braga,
Portugal; 2Vitreous, Retina, Macula Consultants
of New York, New York, NY; 3Ophthalmology,
Columbia University Medical Center, New York,
NY; 4Ophthalmology, New York University, New
York, NY *CR
4936 — D0375 Ranibizumab versus
Bevacizumab in the treatment of subfoveal
choroidal neovascular membrane secondary
to pathologic myopia. Ramón Domínguez
Fernández1, A. Govetto1, M. Alves Perez2, R.
Lorente1. 1Ophthalmology, CHU Ourense, Ourense,
Spain; 2Biostatistics, CHU Ourense, Ourense, Spain
4937 — D0376 Changes in retinal layer
morphology following intra-vitreal Ozurdex
therapy for macular oedema secondary to
Retinal Vein Occlusion. Rashmi Akshikar, S.
Sivaprasad. Ophthalmology, Kings College
Hospital London, London, United Kingdom *CR
Wednesday Posters
11:00 am – 12:45 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
315
Wednesday – Workshop/SIGs
TCC 304
606/607
611-614
Wednesday, May 08, 2013 1:00 PM-2:30 PM
Wednesday, May 08, 2013 1:00 PM-2:30 PM
Wednesday, May 08, 2013 1:00 PM-2:30 PM
Multidisciplinary Ophthalmic Imaging
449 Managing Your Research, Teaching 450 Getting Published: The Good, the
and Service: “Dollarly/Scholarly”
Bad, and the Ugly
448 Multidisciplinary Ophthalmic
Imaging Group: Functional
Optical Imaging
Optical techniques are known to provide high
resolution images of tissue structures. Technological
advances in optical coherence tomography,
scanning laser ophthalmoscopy, photoacoustic
ophthalmoscopy now provide means for imaging
function as well. The possible functional
measurements include ocular blood flow, oxygen
tension, and their responses to visual stimulation.
These techniques are useful for in vivo investigation
in both animals and humans. Clinical applications
may be possible in the future.
Moderators: Joel S. Schuman, David Huang
and Gadi Wollstein
— 1:00 Introduction
— 1:05 Laser Speckle Flowgraphy in
Glaucoma. Toru Nakazawa. Ophthalmology,
Tohoku Univ Graduate Sch of Med, Sendai, Japan
*CR
— 1:20 Dual-beam Bidirectional OCT. Leopold
Schmetterer. Clinical Pharmacology, Medical
University of Vienna, Vienna, Austria
— 1:35 Erythrocyte Velocity Measurement
with Adaptive Optics Scanning Laser
Ophthalmoscopy. Stephen A. Burns. School of
Optometry, Indiana University, Bloomington, IN
Wednesday Workshops/
SIGs
1:00 pm – 2:30 pm
— 1:50 Retinal Oxymetry by Photoacoustic
Ophthalmoscopy. Hao F. Zhang. Biomedical
Engineering, Northwestern University, Evanston,
IL *CR
— 2:05 Retinal Oxygen Tension Imaging.
Mahnaz Shahidi. Ophthalmology & Visual
Sciences, University of Illinois at Chicago, Chicago,
IL *CR
— 2:20 Discussion/Business Meeting
Managing time commitments is an extremely
important skill needed to accomplish your
professional goals. As a faculty member in a
research university, the three major areas of work
are 1) research, 2) teaching, and 3) committee/
community service. For those in industry research
positions, personnel management may replace
teaching as a component of your job. The level of
success in these areas plays a major role in your
personnel evaluations and your promotions. This
is an area of professional life that is rarely taught
in formal presentations. As a young professional,
from a diverse background (a woman or, a
minority, or both), you will find yourself pulled
in various directions as many people want you
to serve on their different committees, in order
to meet institutional diversity requirements. This
workshop will concentrate on managing your time
and effort, both quantitatively and qualitatively, to
achieve success in all three areas. Implicit in this
management effort is success in providing time for
yourself and family. The invited speaker(s) will
address their own experiences, challenges, failures
and successes in this critical area of professional
life. From their life experience, you may gain
valuable knowledge and skills to navigate this
important aspect of your life.
This workshop will focus on practical and
ethical issues relevant to publishing and the peer
review process, addressing the responsibilities
of both authors and reviewers. Topics will
include: plagiarism, its definition, detection,
and consequences; the elements of a “good”
(constructive) review, and things to avoid when
writing reviews; reviewer conflicts of interest, and
maintaining confidentiality.
Moderators: Steven J. Fliesler and
Ron A. Adelman
— 1:00 Introduction
— 1:05 Authorship Ethics: Plagiarism Walking on the Dark Side. Steven J. Fliesler.
Ophthalmology, SUNY-Buffalo / VA Med CtrBuffalo, Buffalo, NY
— 1:30 Good Reviews, Bad Reviews: How to
Do One and Not the Other. Jeffrey H. Boatright.
Ophthalmology, Emory University School of Med,
Atlanta, GA
— 1:55 Reviewer Ethics: Doing the Right
Thing. David C. Beebe. Ophthalmol & Visual Sci,
Washington Univ, St Louis, MO *CR
— 2:20 Discussion
Moderators: Jerome Wujek and Joseph Carroll
— 1:00 Introduction
— 1:05 Presentation. Janey L. Wiggs.
Ophthalmology-Harvard Med Sch, Mass Eye & Ear
Infirmary, Boston, MA
— 1:17 Presentation. Emily Y. Chew.
Epidemiology & Clinical Applications, National
Eye Inst/NIH, Bethesda, MD
— 1:29 Presentation. Terri L. Young.
Ophthalmology, Duke University Eye Center,
Durham, NC *CR
— 1:41 Presentation. Nisha Acharya. OphthalProctor Foundation, Univ of California - SF, San
Francisco, CA
— 1:53 Presentation. Cynthia L. Grosskreutz.
Ophthalmology, Novartis Inst for Biomed Resrch,
Cambridge, MA *CR
— 2:05 Discussion
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
316
Wednesday – Workshops/SIGs
615-617
TCC 301/302
6A
Wednesday, May 08, 2013 1:00 PM-2:30 PM
Wednesday, May 08, 2013 1:00 PM-2:30 PM
Wednesday, May 08, 2013 1:00 PM-2:30 PM
451 Indo-US Collaborative Vision
Research Program
452 Pizza with the Experts #2
Retinal Cell Biology / Retina
The Indo-U.S. Collaborative Vision Research
Program has supported more than a dozen
collaborative and productive relationships since its
formalization in 2005. The representatives of the
governments of India and the U.S. have worked
together to create a number of opportunities for
the vision researchers to jointly submit and receive
funding to pursue projects on genetic ocular traits,
cataract, glaucoma, diabetic retinopathy, retinal
degeneration and neuroplasticity. The program is
supported by the R01 research grant at NIH and
an award mechanism supported by the Department
of Biotechnology, Government of India. Leading
vision researchers from the US and India will
discuss the current programs, future opportunities,
award mechanisms, various challenges and ways
to achieve successful results in a collaborative
program across the globe. The participants will have
the opportunity to learn about the scientific projects
sponsored through the bilateral research program.
Moderators: Gyan Prakash and T.S. Rao
— 1:00 Intervational Vision Research. Paul A.
Sieving. National Eye Institute, Bethesda, MD
— 1:12 Overview of Application Process
for Indo-US Vision Research Program. Gyan
Prakash. National Eye Institute, NIH, Bethesda,
MD
Advance registration required. Trainees,
students and junior faculty, don’t miss this
unique opportunity to network and gain valuable
information from those who have been in your
shoes! This very popular program offers informal
discussions over a pizza lunch on a wide range of
topics to provide personal guidance, insight and
skills to help you advance your career! Topics will
focus on professional development, career guidance,
and best practices of interest to basic and clinical
trainees and clinician-scientists. A number of the
roundtable topics will be specifically tailored to the
needs of clinician-scientists.
TCC 303
Wednesday, May 08, 2013 1:00 PM-2:30 PM
453 NIH-CSR Peer Review Workshop
Sponsored by the NIH Center for Scientific Review
(CSR), this workshop is designed to inform grant
applicants and also reviewers about the NIH peer
review process and the changes that have occurred,
including the recent reorganization of study sections
that review visual system grant applications.
Scientific Review Officers (SROs) from CSR will
be on hand for the presentation and will be available
to answer questions.
454 What Role Do Mueller Glial Cells
Play in Retinal Pathology? - SIG
Very little is known about the contribution of
Mueller cells to the pathogenesis of retinal
disease. Evidence will be presented suggesting
that Mueller cell dysfunction may result in key
vision-threatening events, such as photoreceptor
degeneration and retinal edema.
Moderators: Marcus Fruttiger and G Astrid Limb
— 1:00 SIG Organizer. Mark C. Gillies.
Ophthalmology, University of Sydney, Sydney,
NSW, Australia *CR
— SIG Organizer. Francine F. Behar-Cohen.
Ophthalmology, Hotel Dieu de Paris, Universite
Paris Descartes, Paris, France *CR
— Consequences of Selective Muller cell
Ablation in a Transgenic Model. Mark C. Gillies.
Ophthalmology, University of Sydney, Sydney,
NSW, Australia *CR
— Glia in Retinal Vascular Disease. Erica L.
Fletcher. Dept Anatomy/Neuroscience, University
of Melbourne, Parkville, VIC, Australia *CR
— Retinal Glia: Novel Mineralocorticoid
Targets. Francine F. Behar-Cohen. Ophthalmology,
Hotel Dieu de Paris, Universite Paris Descartes,
Paris, France *CR
Moderator: Michael H. Chaitin
6B
— 1:00 Overview: Peer Review
Wednesday, May 08, 2013 1:00 PM-2:30 PM
— 1:36 Indo-US Programs: Challenges and
Benefits of the Bilateral Scientific Research
Opportunities. Nandita Chopra. Dept. of Health &
Human Services, US Embassy, Bethesda, MD
— 1:20 Biology of the Visual System (BVS)
Study Section. Michael H. Chaitin. Center for
Scientific Review, NIH, Bethesda, MD
Retina
— 1:48 India US Genetic Study of
Ocular Quantitative Traits. Janey L. Wiggs.
Ophthalmology-Harvard Med Sch, Mass Eye & Ear
Infirmary, Boston, MA
— 2:00 Diabetic Retinopathy - The Looming
Global Health Crisis. P. Namperumalsamy.
Research, Aravind Medical Research Foundation,
Madurai, India
— 2:12 Discussion
— 1:30 Diseases and Pathophysiology of the
Visual System (DPVS) Study Section. Nataliya
V. Gordiyenko. Center for Scientific Review, NIH,
Bethesda, MD
— 1:40 Small Business: Sensory Technologies
[ETTN-12] Study Section. Paek-Gyu Lee. Center
for Scientific Review, NIH, Bethesda, MD
— 1:50 Bioengineering of Neuroscience, Vision,
and Low Vision Technologies (BNVT) Study
Section. Robert C. Elliott. Center for Scientific
Review, NIH, Bethesda, MD
— 2:00 Title - to be determined by author.
Maqsood A. Wani. NIH, Bethesda, MD
— 2:10 Panel Discussion
455 Diabetic Retinopathy: Where We
Are and a Path to Progress - SIG
The Lasker/IRRF Initiative explored diabetic
retinopathy, a serious ocular complication of
diabetes mellitus, and the possible connection
between the rise in blood glucose levels to changes
in neuronal/glial function and to vascular changes
that eventually can destroy vision in the eye.
Moderator: John E. Dowling
— SIG Organizer. John E. Dowling. Molecular
and Cellular Biology, Harvard University,
Cambridge, MA
— Vascular and Neuronal Repair. Robert N.
Frank. Ophthalmology, Wayne State Univ/Kresge
Eye Inst, Detroit, MI
— Early Signs of Diabetic Retinopathy. Thomas
W. Gardner. Ophthalmology, Kellogg Eye Ctr Univ
of Michigan, Ann Arbor, MI *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
317
Wednesda Workshops/
SIGs
1:00 pm – 2:30 pm
— 1:24 Vision Research Projects Collaborative Case Studies. C M. Rao. Center for
Cell & Molec Biology, Hyderabad, India
Wednesday – Workshop/SIGs
— Role of Glucose, Lipids and Oxygen
in Diabetic Retinopathy. Timothy S. Kern.
Department of Medicine, Case Western Reserve
Univ, Cleveland, OH *CR
— Diagnostic Methods. Larry A. Donoso.
Research, Philadelphia Retina Endowment Fund,
Philadelphia, PA
TCC LL 4/5
Wednesday, May 08, 2013 1:00 PM-2:30 PM
Wednesday, May 08, 2013 1:00 PM-2:30 PM
Cornea / Biochemistry/Molecular Biology /
Glaucoma / Retina
Retina
457 Dietary Factors and Eye Health SIG
458 New Paradigms and Emerging
Techniques for Minimalist Macular
Photocoagulation - SIG
There is growing interest in dietary factors and
supplements that may have protective effects
against eye diseases. This SIG will focus on
nutritional factors which are beneficial for the
eye. Exciting new research data and potential
mechanisms will be presented and discussed.
Laser treatments for macular edema have shifted
toward minimal invasiveness in the era of antiVEGF therapy. Various techniques including
micropulsing, nanopulsing, and navigated
microaneurysm treatment will be discussed.
456 Epigenetic Mechanism and Ocular
Diseases - SIG
Moderators: Kazuo Tsubota and Rajendra S. Apte
Moderators: William R. Freeman, Johann Roider,
Bert M. Glaser and Giovanni Staurenghi
The SIG will update the research of epigenetic
modifications in diabetic retinopathy, retinal
development, corneal dystrophy, AMD and PVR
and the roles of DNA-methylation, histoneacetylation and miRNA in the pathogenesis of
these diseases and its treatment by epigenetic
intervention.
— SIG Organizer. Kazuo Tsubota. Ophthalmology,
Keio Univ School of Medicine, Shinjuku-ku, Japan
*CR
— SIG Organizer. Richard B. Rosen.
Ophthalmology, New York Eye & Ear Infirmary,
New York, NY *CR
— Lutein, Zeaxanthin, and Omega-3 Fatty
Acid Function in the Human Macula: The Basic
Science Underlying AREDS2. Paul S. Bernstein.
Ophthal and Visual Sciences, Univ of Utah/Moran
Eye Center, Salt Lake City, UT *CR
— Navigated Laser Therapy. William R. Freeman.
Ophthalmology, UCSD Jacobs Retina Center, La
Jolla, CA *CR
— Present and Proposed Approaches to
Therapeutics. Lloyd M. Aiello. Beetham Eye
Institute, Joslin Diabetes Center, Boston, MA
6C
Wednesday, May 08, 2013 1:00 PM-2:30 PM
Retinal Cell Biology
Moderator: Renu A. Kowluru
— SIG Organizer. Renu A. Kowluru.
Ophthalmology, Wayne State Univ/Kresge Eye Inst,
Detroit, MI
— Histone modifications in diabetic retinopathy.
Renu A. Kowluru. Ophthalmology, Wayne State
Univ/Kresge Eye Inst, Detroit, MI
— DNA Methylation in RPE Transdifferentiation
and its relevance to proliferative
vitreoretinopathy. Shikun He. OphthalmologyUSC, Doheny Eye Institute, Los Angeles, CA
Wednesday Workshops/
SIGs
1:00 pm – 2:30 pm
618-620
— The Protective Effects of Resveratrol are
Mediated through Forkhead Box O Activity.
Pratap Challa. Dept of Ophthalmology, Duke
University Eye Center, Durham, NC
— Omega-3 and Macular Pigment
Accumulation: Results from the PIMAVOSA
Study. Marie-Noelle Delyfer. Ophthalmology,
Hopital Pellegrin, Bordeaux, France *CR
— Nanopulse Laser Therapy. Johann Roider.
Klinik fur Ophthalmologie, University of Kiel, Kiel,
Germany *CR
— Micropulse Laser Therapy. Bert M. Glaser.
Ocular Proteomics, National Retina Institute,
Towson, MD *CR
— Feeder Vessel Therapy. Giovanni Staurenghi.
Dept of Biomedical and Clinical Science (Luigi
Sacco), University of Milan, Milano, Italy *CR
— The Novel Potential of Lactoferrin for Ocular
Surface Health. Motoko Kawashima. Department
of Ophthalmology, Keio University School of
Medicine, Shinjuku ku, Japan *CR
— When Good RPE Break Bad: A meta-genomic
analysis of chronic RPE stress and aging.
Monte Radeke. Neuroscience Research Institute,
University of California, Santa Barbara, CA
— Epigenetic factors in the pathogenesis of
corneal dystrophy. Xiaohua Li. Henan eye institue,
Zhengzhou, China
— Histone modification in regulation of retinal
development. Dong F. Chen. Ophthalmology/
Harvard, Schepens Eye Res Inst, Harvard Med Sch,
Boston, MA *CR
— DNA methylation in regulation of retinal
development. Shannath L. Merbs. Ophthalmology,
Wilmer Eye Institute, Johns Hopkins Univ,
Baltimore, MD
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
318
4938 – 4958 – Wednesday – Papers/Minisymposium
6B
6C
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Glaucoma
Retina
459 Neuroprotection
460 ROP: Management
Moderators: Leonard A. Levin, Robert W. Nickells
and M Francesca Cordeiro
Moderator: R.V. Paul Chan
4938 — 2:45 Ocular Hypotensive and
Neuroprotective Effects of Agmatine. Samin
Hong. Ophthalmology, Yonsei University College
of Medicine, Seoul, Republic of Korea
4939 — 3:00 The Jigsaw Effect: Clinical
Evidence for CNS Control of Visual Field Loss
in Chronic Glaucoma. Willliam E. Sponsel1, 2,
N. Satsangi3, M. A. Reilly1, S. L. Groth4, S. J.
McKinnon5. 1Biomedical Engineering, University
of Texas - San Antonio, San Antonio, TX;
2
Madison Square Bldg Ste 306, WESMDPA, San
Antonio, TX; 3School of Medicine, University of
Texas Health Science Center - San Antonio, San
Antonio, TX; 4School of Medicine, University of
Minnesota, Minneapolis, MN; 5Ophthalmology and
Neurobiology, Duke University, Durham, NC *CR
4940 — 3:15 AAV-Mediated Neurotrophin-4
Is Neuroprotective In Murine Model
Of Microbead-Induced Glaucoma with
Neurotrophin Expression in the Visual Pathway.
Anna M. Demetriades, L. Guo, C. Pan. Glaucoma
Research Laboratory, Weill Cornell Medical
College, New York, NY
4941 — 3:30 The Effect of Modulators of
Microtubule Stability on Dendritic Morphology
in Cultured Retinal Ganglion Cells. Rachel
Chong1, B. Lorber1, K. R. Martin1, 2. 1John Van
Geest Centre for Brain Repair, University of
Cambridge, Cambridge, United Kingdom; 2NIHR
Biomedical Research Centre, University of
Cambridge, Cambridge, United Kingdom
4943 — 4:00 Neuroprotection from excitotoxic
RGC death: is there a role for MMPs? Lies
De Groef, M. A. Salinas-Navarro, E. Dekeyster,
K. Lemmens, D. Gaublomme, I. Van Hove, L. K.
Moons. Department of Biology, Laboratory for
Neural Circuit Development and Regeneration, KU
Leuven, Leuven, Belgium
4944 — 4:15 TrkB Receptor Agonists as
Neuroprotective Molecules in Glaucoma -Effect
of 7,8 Dihydroxyflavone. Stuart Graham1, 2, Y.
You1, J. C. Li1, V. Gupta1. 1Australian School of
Advanced Medicine, Macquarie University, Sydney,
NSW, Australia; 2Save Sight Institute, Sydney
University, Sydney, NSW, Australia
4946 — 3:00 Long term outcomes of lens
clarity following lens-sparing vitrectomy for
retinopathy of prematurity. Eric Nudleman, A.
Capone, K. A. Drenser, M. T. Trese. Associated
Retinal Consultants, William Beaumont Hospital,
Royal Oak, MI *CR
4947 — 3:15 Risk factors for retinopathy of
prematurity (ROP): insights from “outlier”
infants with low or high birth weights. Alexander
D. Port1, R. Chan2, S. Ostmo3, M. F. Chiang3, 4.
1
Weill Cornell Medical College, New York, NY;
2
Ophthalmology, Weill Cornell Medical College,
New York, NY; 3Ophthalmology, Oregon Health
& Science University, Portland, OR; 4Medical
Informatics and Clinical Epidemiology, Oregon
Health & Science University, Portland, OR *CR
4948 — 3:30 The postnatal weight-gain
algorithm WINROP early identifies sight
threatening retinopathy of prematurity in
a nation based cohort of extremely preterm
infant. Pia Lundgren1, 2, E. Stoltz Sjöström3, M.
Domellöf3, G. Holmström4, A. Hård2, C. Lofqvist2,
A. Hellström2. 1Ophthalmology, Umeå University,
Umeå, Sweden; 2Ophthalmology, Sahlgrenska
academy at University of Gothenburg, Gothenburg,
Sweden; 3Pediatrics, Umeå University, Umeå,
Sweden; 4Ophthalmology, Uppsala University,
Uppsala, Sweden *CR
4949 — 3:45 Detection of Threshold
Retinopathy of Prematurity using the PINT-ROP
Growth Model. Anupam Kumar, D. Morrison.
Vanderbilt University School of Medicine,
Nashville, TN *CR
4950 — 4:00 Feasibility of Color Doppler
Spectral Domain Optical Coherence
Tomography in premature infants undergoing
Retinopathy of Prematurity screening. Ramiro
S. Maldonado1, E. L. Yuan1, D. Tran-Viet1, S. F.
Freedman1, 2, D. Wallace1, 2, H. C. Hendargo3,
J. A. Izatt3, C. A. Toth1, 3. 1Duke University Eye
Center, Durham, NC; 2Pediatrics, Duke University
School of Medicine, Durham, NC; 3Biomedical
Engineering, Duke University, Durham, NC *CR
6E
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Retina
461 Retinal Detachment II
Moderators: Toshinori Murata and
Ron A. Adelman
4952 — 2:45 The Management of Retinal
Detachments in Patients with Severe Mental
Disabilities. Kirk H. Packo1, J. M. Civantos1, J. A.
Cohen1, J. S. Pollack1, P. T. Merrill1, S. de Bustros1,
B. Garretson2. 1Ophthalmology, Rush University
Medical Center, Chicago, IL; 2Ophthalmology,
Oakland University William Beaumont School of
Medicine, Royal Oak, IL *CR
4953 — 3:00 Management of Uncomplicated
Retinal Detachments: A Multicenter Study. Ron
A. Adelman1, A. Parnes1, D. Ducournau2. 1Ophthal
& Visual Science, Yale Univ Sch of Medicine, New
Haven, CT; 2Clinique Sourdille, Nantes, France
4954 — 3:15 Primary Scleral Buckling:
A Safe and Effective Treatment Option for
Retinal Detachment. Frank Ruda1, A. Jirgis2, 3,
N. Jabbour1, 2. 1West Virginia University Eye
Institute, Morgantown, WV; 2ForSight Foundation,
Morgantown, WV; 3National Eye Institute - Cairo,
Cairo, Egypt
4955 — 3:30 Quantifying the Effects of
Enzymatic Vitreolysis Reveals Biomechanical
Roles of Structural Macromolecules in Shear
and Extension. Benjamen Filas, Q. Zhang, Y. Shui,
D. C. Beebe. Ophthalmology and Visual Sciences,
Washington University School of Medicine, St.
Louis, MO *CR
4956 — 3:45 Traditional versus Extreme
Pneumatic Retinopexy. Darin R. Goldman, C. P.
Shah, J. S. Heier. Retina, Ophthalmic Consultants
of Boston, Boston, MA *CR
4957 — 4:00 Pediatric Rhegmatogenous
Retinal Detachment Surgery by Segmental
Scleral Bucking: Risk Factors and Anatomical
Outcomes. Sidath E. Liyanage, M. Errera, R.
Moya, S. Wong, E. Ezra. Vitreoretinal Department,
Moorfields Eye Hospital, London, United Kingdom
4958 — 4:15 Prophylactic Treatments for
Retinal Tears/Detachment in Stickler Syndrome:
Single Institution Experience. Kiran Turaka, S.
Bryan, A. J. Gordon, H. M. Kwong, C. H. Sell.
Retina, Associated Retina Consultants Ltd, Phoenix,
AZ
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
319
Wednesday Papers
Minisymposium
2:45 pm – 4:30 pm
4942 — 3:45 Enhanced retinal ganglion
cell survival in glaucoma by hypoxic
postconditioning after disease onset. Yanli Zhu1,
L. Zhang1, C. Chiang2, J. Gidday1. 1Neurosurgery,
Washington Univ Sch of Med, St Louis, MO;
2
Radiology, Washington Univ Sch of Med, St.
Louis, MO
4945 — 2:45 Length of daylight during early
gestation is an independent predictor of risk
for severe retinopathy of prematurity. Michael
B. Yang1, 2, S. Rao1, D. R. Copenhagen3, 4, R. A.
Lang1, 2. 1Ophthalmology/Visual Systems Group/
Abrahamson Pediatric Eye Institute, Cincinnati
Children’s Hospital Medical Center, Cincinnati,
OH; 2Ophthalmology, University of Cincinnati,
Cincinnati, OH; 3Ophthalmology, University of
California San Francisco, San Francisco, CA;
4
Physiology, University of California San Francisco,
San Francisco, CA *CR
4951 — 4:15 Use of Computer-Assisted
Quantitative Analysis of Retinal Vascular
Dilation and Tortuosity to Predict Need for
Laser Treatment in Retinopathy of Prematurity.
Katherine Wu1, D. Wallace2, S. F. Freedman2.
1
School of Medicine, Duke University, Durham,
NC; 2Ophthalmology and Pediatrics, Duke
University, Durham, NC *CR
4959 – 4974 – Wednesday – Papers/Minisymposium
609
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Lens
462 Lens Proteins/Physical Chemistry
Moderators: Suraj P. Bhat and Jayanti Pande
4959 — 2:45 Presence of αA-crystallin and
αB-crystallin as two Independent Proteins in
the Developing Ocular Lens: Evidence from
Transmission Electron Microscopy. Rajendra K.
Gangalum1, J. Horwitz1, S. A. Kohan3, I. Dighe1,
S. P. Bhat1, 2. 1Ophthalmology, Jules Stein Eye
Institute, UCLA, Los Angeles, CA; 2Molecular
Biology Institute @ UCLA, Los Angeles, CA;
3
Brain Research Insitute, Los Angeles, CA
Wednesday Papers/
Minisymposium
2:45 pm – 4:30 pm
4960 — 3:00 Targeted disruption of lens
αA-crystallin in Zebrafish (Danio Rerio).
Hassane S. Mchaourab, P. Zou, W. Chen. Molec
Physiol&Biophys-Med Ctr, Vanderbilt University,
Nashville, TN
4965 — 4:15 Statistical-thermodynamic
model for charge-regulation properties of
bovine γB-crystallin. George M. Thurston1, M.
Martini1, 3, C. W. Wahle2, D. Hollenbeck1, D. S.
Ross2, J. F. Hamilton2. 1Physics, Rochester Institute
of Technology, Rochester, NY; 2Mathematics,
Rochester Institute of Technology, Rochester,
NY; 3Physics, University of Illinois at UrbanaChampaign, Urbana-Champaign, IL
611-614
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Retinal Cell Biology
463 Transplanted and Endogenous
Cells as Effectors of Outer Retinal
Repair - Minisymposium
This Minisymposium will provide an overview of
the emerging approaches for developing cell-based
therapies to treat diseases of the outer retina.
4961 — 3:15 Surface-enhanced Raman
spectroscopy (SERS) of gamma crystallins: A
promising technique to study the redox reactions
of cysteine residues in dilute protein solutions.
Jayanti Pande1, J. A. Gomez-Santos2, 1, A. Pande1.
1
Department of Chemistry, University at AlbanySUNY, Albany, NY; 2Department of Chemistry,
Universidad Industrial de Santander, Bucaramanga,
Colombia
Moderators: David M. Gamm and
Peter F. Hitchcock
4962 — 3:30 Identification and Spatial
Localization of Ocular Lens Age- and CataractSpecific Protein Signatures. Kevin L. Schey1, 2,
K. M. Rose1, D. M. Anderson1. 1Biochemistry,
Vanderbilt University, Nashville, TN;
2
Ophthalmology and Visual Sciences, Vanderbilt
University, Nashville, TN
4967 — 3:10 Directing the Adult RPE Stem
Cell to Promote Retinal Repair. Sally Temple.
Neural Stem Cell Institute, Rensselaer, NY *CR
4963 — 3:45 Expression and Distribution
of Thiol-Regulating Enzyme Glutaredoxin 2
(Grx2) in Porcine Ocular Tissues. Xiaoli Tian1,
B. P. Upadhyaya1, H. Wu1, M. F. Lou1, 2. 1School
of Veterinary Medicine and Biomedical Sciences,
University of Nebraska-Lincoln, Lincoln, NE;
2
Redox Biology Center, University of Nebraska
Lincoln, Lincoln, NE
4964 — 4:00 Expression of K6W-mutant
ubiquitin in human lens epithelial cells (HLEC)
alters conformation and linkages of polyubiquitin chains. Allen Taylor1, K. Liu1, M.
Chang1, B. E. Riley2, T. A. Shaler3, K. M. Rose4,
K. L. Schey4, F. Shang1. 1Nutrition &Vision ResUSDA-HNRCA, Tufts University, Boston, MA;
2
Elan Pharmaceuticals Inc, South San Francisco,
CA; 3Stanford Research Institute, Menlo Park, CA;
4
Mass Spectrometry Research Center, Vanderbilt
University, Nashville, TN
— 2:45 Introduction
4966 — 2:50 Retinal Repair Following
Transplantation of ES-Derived Photoreceptor
Cells. Robin R. Ali. Div of Molecular Therapy,
UCL Institute of Ophthalmology, London, United
Kingdom
4968 — 3:30 Development of Cellular
Therapies Using hESC-derived RPE. Dennis
O. Clegg. Department of Molecular, Cellular and
Developmental Biology, University of California
Santa Barbara, Santa Barbara, CA *CR
4969 — 3:50 The Production of Photoreceptors
and RPE Cells from Adult Retinal Stem Cells.
Derek Van Der Kooy. University of Toronto,
Toronto, ON, Canada
4970 — 4:10 Molecular Mechanisms
Underlying Muller Glia Dedifferentiation and
Proliferation During Regeneration Of The
Damaged Zebra Fish Retina. David R. Hyde. Dept
of Biological Sciences, University of Notre Dame,
Notre Dame, IN
TCC LL 4/5
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Genetics
464 Advances in Ocular Genetics
Moderators: Janey L. Wiggs and Edwin M. Stone
4971 — 2:45 Transgenic TBK1 mouse develops
signs of normal tension glaucoma. John H.
Fingert1, K. A. Miller1, F. Solivan-Timpe1, B. Roos1,
A. L. Robin2, R. F. Mullins1, M. G. Anderson3.
1
Ophthalmology, University of Iowa, Iowa City, IA;
2
Ophthalmology and International Health, Johns
Hopkins University, Baltimore, MD; 3Physiology,
University of Iowa, Iowa City, IA *CR
4972 — 3:00 Dominant-negative RBP4
mutations cause congenital eye malformations
through a maternal-fetal nutritional interaction.
Tom M. Glaser1, 2, C. Chou2, S. A. Tarle2, J. Pribila4,
T. Bardakjian5, A. S. Schneider5, C. C. Nelson3, T.
M. Glaser1, 2. 1Cell Biology & Human Anatomy,
Univ of California, Davis School of Medicine,
Davis, CA; 2Human Genetics, Univ Michigan, Ann
Arbor, MI; 3Ophthalmology, Univ Michigan, Ann
Arbor, MI; 4Pediatric Ophthalmology, Park Nicollet
Hospital, Lincoln Park, MN; 5Genetics, Albert
Einstein Medical Center, Philadelphia, PA
4973 — 3:15 Non-exomic and synonymous
variants in ABCA4 are an important cause
of Stargardt disease. Edwin M. Stone1, 2, B. A.
Tucker1, T. A. Braun1, R. F. Mullins1, A. H. Wagner1,
S. G. Jacobson3, A. V. Cideciyan3, B. L. Lam4, G. A.
Fishman5. 1Department of Ophthalmology, Institute
for Vision Research, University of Iowa, Iowa City,
IA; 2Howard Hughes Medical Institute, Iowa City,
IA; 3Department of Ophthalmology, Scheie Eye
Institute, University of Pennsylvania, Philadelphia,
PA; 4Department of Ophthalmology, Bascom
Palmer Eye Institute, University of Miami, Miami,
FL; 5Chicago Lighthouse for People Who Are Blind
or Visually Impaired, Chicago, IL *CR
4974 — 3:30 Application of Whole-Exome
and Retinal-Capture Next-Generation DNA
Sequencing to Identify Disease-Causing
Mutations in Families with a Diagnosis of
Autosomal Dominant Retinitis Pigmentosa.
Stephen P. Daiger1, L. S. Sullivan1, S. J. Bowne1,
G. M. Weinstock2, D. C. Koboldt2, R. Chen3, J. R.
Heckenlively4, K. E. Branham4, D. G. Birch5, D.
K. Wheaton5. 1Human Genetics Center, School of
Public Health, The Univ. of Texas Health Science
Center, Houston, TX; 2The Genome Institute,
Washington University, St. Louis, MO; 3Dept. of
Molecular and Human Genetics, Baylor College of
Medicine, Houston, TX; 4Kellogg Eye Center, Univ.
of Michigan, Ann Arbor, MI; 5Retina Foundation of
the Southwest, Dallas, TX *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
320
Wednesday – Papers/Minisymposium – 4975 – 4984
4975 — 3:45 Rare and common variants in
extracellular matrix gene fibrillin 2 (FBN2)
are associated with inherited and age-related
macular degeneration, respectively. Anand
Swaroop1, R. Priya1, X. Zhan2, R. Fariss1, K. E.
Branham2, E. Y. Chew1, D. Stambolian4, S. S.
Bhattacharya3, J. R. Heckenlively2, G. Abecasis2.
1
N-NRL, Bldg 6, National Eye Institute,
Bethesda, MD; 2University of Michigan, Ann
Arbor, MI; 3Institute of Ophthalmology, London,
United Kingdom; 4University of Pennsylvania,
Philadelphia, PA *CR
4976 — 4:00 Exome sequencing in the midwestern Amish to identify rare variation
influencing AMD. Jessica N. Cooke Bailey1, L.
D’Aoust1, L. Jiang1, R. Laux1, A. Agarwal1, W.
K. Scott2, M. A. Pericak-Vance2, J. L. Haines1.
1
Center for Human Genetics Research, Vanderbilt
University Medical Center, Nashville, TN;
2
Hussman Institute of Human Genomics, Miller
School of Medicine, University of Miami, Miami,
FL *CR
4977 — 4:15 Chipping Away At The Genetics
of Age Related Macular Degeneration. Goncalo
Abecasis1, M. C. Schu3, X. Zhan1, S. Arumugam4,
J. Bragg Gresham1, L. Fritsche2. 1University of
Michigan, Ann Arbor, MI; 2Institute of Human
Genetics, University of Regensburg, Regensburg,
Germany; 3Boston University School of Medicine,
Boston, MA; 4Case Western Reserve University,
Cleveland, OH *CR
TCC 305
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology / Visual Psychophysics /
Physiological Optics
465 Amblyopia: Neural Mechanisms
and Treatment
Moderators: Eileen E. Birch and
Benjamin Thompson
4981 — 3:30 Binocular iPad Treatment
for Amblyopia. Simone Li1, V. Subramanian1,
L. To2, R. M. Jost1, S. Jost1, D. R. Stager3, L.
Dao4, D. R. Stager4, E. E. Birch1, 5. 1Pediatrics,
Retina Foudation of the Southwest, Dallas, TX;
2
Schepens Eye Research Institute, Boston, MA;
3
Pediatric Ophthalmology and the Center for Adult
Strabismus, Dallas, TX; 4Pediatric Ophthalmology
and Adult Strabismus, Plano, TX; 5Ophthalmology,
University of Texas Southwestern Medical Center,
Dallas, TX *CR
4982 — 3:45 Dichoptic perceptual learning
induces visual cortex plasticity in adults
with amblyopia. Jinrong Li1, 2, B. Thompson3,
D. Deng2, L. Y. Chan4, M. Yu1, 2, R. F. Hess5.
1
Department of Optometry and Vision Science,
Sun Yat-sen University, Guangzhou, China; 2State
Key Laboratory of Ophthalmology, Zhongshan
Ophthalmic Center, Sun Yat-sen University,
Guangzhou, China; 3Optometry and Vision Science,
University of Auckland, Auckland, New Zealand;
4
The Hong Kong Polytechnic University, The Hong
Kong Polytechnic University, Hong Kong, China;
5
Department of Ophthalmology, McGill University,
Montreal, QC, Canada *CR
4983 — 4:00 Anodal tDCS Enhances the Effect
of Binocular Therapy on Stereopsis in Adults
with Amblyopia. Daniel P. Spiegel1, J. LI2, R. F.
Hess3, W. D. Byblow4, L. To5, J. R. Cooperstock6,
M. Yu2, B. Thompson1. 1Department of Optometry
and Vision Science, The University of Auckland,
Auckland, New Zealand; 2State Key Laboratory of
Ophthalmology, Zhongshan Ophthalmic Center,
Sun Yat-sen University, Guangzhou, China;
3
Department of Ophthalmology, McGill University,
Montreal, QC, Canada; 4Department of Sport and
Exercise Science, The University of Auckland,
Auckland, New Zealand; 5Schepens Eye Research
Institute, Boston, MA; 6Department of Electrical
and Computer Engineering, McGill University,
Montreal, QC, Canada *CR
4984 — 4:15 Attention deficits in human
strabismic amblyopia measured via neural
responses to texture-defined forms: A highdensity EEG mapping study. Chuan Hou1, A.
Norcia2, P. Verghese1, S. P. McKee1. 1The SmithKettlewell Eye Research Institute, San Francisco,
CA; 2Stanford University, Stanford, CA
4979 — 3:00 Concordance with occlusion
therapy for childhood amblyopia. Michael P.
Wallace1, C. E. Stewart1, M. J. Moseley1, D. A.
Stephens2, A. R. Fielder1. 1Optometry and Visual
Science, City University, London, United Kingdom;
2
Mathematics and Statistics, McGill University,
Montreal, QC, Canada f
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
321
Wednesday Papers
Minisymposium
2:45 pm – 4:30 pm
4978 — 2:45 Retinal genes and proteins
associated with postnatal visual deprivation in
rats. Melissa Meyer zu Horste1, 2, V. ProkoschWilling3, H. Melkonyan3, T. Stupp3, S. Thanos3.
1
Ophthalmology, University Hospital of DuisburgEssen, Essen, Germany; 2Ophthalmology,
Angiogenesis Laboratory, Massachusetts Eye and
Ear Infirmary, Cambridge, MA; 3Experimental
Ophthalmology, School of Medicine, WestfalianWilhelms-University Muenster, Muenster, Germany
4980 — 3:15 Patching therapy for amblyopia,
are we patching the wrong eye? Jiawei Zhou1, B.
Thompson2, R. F. Hess1. 1Ophthalmology, McGill
University, Montreal, QC, Canada; 2Optometry and
Vision Science, University of Auckland, Auckland,
New Zealand *CR
4985 – 5004 – Wednesday – Posters
Exhibit Hall A0114-A0145
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Biochemistry/Molecular Biology
466 AMD II, BI
Moderator: Alecia K. Gross
4985 — A0114 Comparison of the Gene
Expression by Haplogroups H and J:
Implications for AMD (Age Related Macular
Degeneration). Claudio A. Ramirez1, M. Chwa1,
S. Atilano1, D. Malik1, J. Cáceres del Carpio1,
M. Tarek1, S. Jazwinski2, M. V. Michael2, B. D.
Kuppermann1, C. M. Kenney1. 1Gavin Herbert Eye
Institute, University of California, Irvine, Irvine,
CA; 2Tulane Center for Aging, Tulane University,
New Orleans, LA *CR
4986 — A0115 Hops Extract Xanthohumol
Protects Visual Acuity and Function After Light
Damage. Stephanie L. Foster, N. F. Henneman,
M. A. Chrenek, C. B. Wright, J. H. Boatright.
Ophthalmology, Emory Univ School of Med,
Atlanta, GA
Wednesday Posters
2:45 pm – 4:30 pm
4987 — A0116 Role of Apoptotic Regulatory
Proteins in Retinoblastoma. Lata Singh1, S.
Kashyap1, N. Pushker2, S. Sen1, S. Bakhshi3, A.
Sharma4, N. Saini5, J. Kaur6. 1Ocular Pathology,
All India Institute of Medical Sciences, New
Delhi, India; 2Ophthalmology, All India Institute
of Medical Sciences, New Delhi, India; 3Medical
Oncology, IRCH, All India Institute of Medical
Sciences, New Delhi, India; 4Ocular Microbiology,
All India Institute of Medical Sciences, New Delhi,
India; 5Biochemistry, Institute of Genomics and
Integrative Biology, Mall Road, New Delhi, India;
6
Ocular Biochemistry, All India Institute of Medical
Sciences, New Delhi, India
4988 — A0117 Comparison Study of IL-33
Gene Expression in Haplogroup H, J, L, and K
Cybrids. Thomas A. Vo1, M. Chwa1, S. Atilano1,
D. Malik1, C. A. Ramirez1, J. Cáceres del Carpio1,
S. Jazwinski2, M. V. Michael2, B. D. Kuppermann1,
C. M. Kenney1. 1Opthalmology, Gavin Herbert Eye
Institute at UC Irvine, Irvine, CA; 2Tulane Center
for Aging at Tulane University, New Orleans, LA
*CR
4989 — A0118 Resveratrol Protects
Human Retinal Pigment Epithelial Cells
from Inflammatory Insults. R K. Kutty1,
C. N. Nagineni1, W. Samuel1, T. Duncan1, C.
Vijayasarathy2, C. Jaworski1, T. Redmond1.
1
National Eye Institute, National Institutes of
Health, Bethesda, MD; 2National Institute on
Deafness and Other Communication Disorders,
National Institutes of Health, Bethesda, MD
4990 — A0119 Bone morphogenetic protein
4 induces ID1 and ID3 transcription factors in
trabecular meshwork cells. Avani A. Mody, R.
J. Wordinger, A. F. Clark. Visual sicence /NTERI,
UNTHSC, Fort Worth, TX *CR
4991 — A0120 The proteolytic activity of
HTRA1 is responsible for its pathological role
in polypoidal choroidal vasculopathy. Sandeep
Kumar1, 2, A. Jones1, 2, Z. Berriochoa2, S. Wang2, Y.
Fu1, 2. 1Moran Center for Translational Medicine,
University of Utah, Salt Lake City, UT; 2Dept of
Ophthalmology and Visual Sciences, University of
Utah, Salt Lake City, UT *CR
4998 — A0127 An In-Vitro Study of Wnt
Pathway Modulation in Cybrid H and J
Mitochondrial Haplogroups and the Possible
Implications for Age-related Macular
Degeneration. Payam Falatoonzadeh1, G. B. Woo1,
N. Udar1, S. Atilano1, M. Chwa1, M. V. Michael2, S.
Jazwinski2, C. M. Kenney1. 1Ophthalmology, Gavin
Herbert Eye Inst., UC Irvine, Irvine, CA; 2Tulane
Center for Aging, Tulane University, New Orleans,
LA *CR
4992 — A0121 Associations between Posterior
Vitreous Detachment and Concentrations of
Various Cytokines in Eyes with Age-related
Macular Degeneration and Normal Control
Eyes. Hidenori Takahashi1, X. Tan2, Y. Nomura2,
A. Iriyama2, Y. Fujino3, Y. Okubo1, A. Sato1,
M. Takezawa1, H. Kawashima1, Y. Yanagi2.
1
Ophthalmology, Jichi Medical University,
Shimotsuke-shi, Japan; 2Ophthalmology, University
of Tokyo, Tokyo, Japan; 3Ophthalmology, Tokyo
KoseiNenkin Hospital, Tokyo, Japan
4999 — A0128 Expression of VEGF-C,
VEGF-D and their Cognate Receptors in
Experimental Choroidal Neovascularization
and Clinical AMD. Kameran Lashkari1, J. Ma1,
G. Teague1, J. G. Arroyo2. 1Schepens Eye Research
Institute/ Massachusetts Eye & Ear, Harvard Med
School, Boston, MA; 2Beth Israel Deaconess
Medical Center, Harvard Med School, Boston, MA
*CR
4993 — A0122 Quantitative Proteomic
Identification of Novel Interacting Partners
for the Serine Protease Htra1. Lili Feng1, E.
Kortvely1, A. Vogt1, K. Boldt1, M. Ueffing1, 2. 1Center
of Ophthalmology, University of Tuebingen,
Tuebingen, Germany; 2Research Unit for Protein
Science, Helmholtz Zentrum München, Neuherberg,
Germany
5000 — A0129 Mitochondrial DNA
Damage Increases with Age-related Macular
Degeneration in the RPE but not Neural
Retina. Marcia R. Terluk1, L. M. Soukup2, S. R.
Montezuma1, D. A. Ferrington1. 1Ophthalmology
and Visual Neurosciences, University of Minnesota,
Minneapolis, MN; 2Biology, University of St.
Thomas, St. Paul, MN
4994 — A0123 Amyloid Beta 1- 42 Promotes
NLRP3-inflammasome Activation In Retinal
Pigmented Epithelial Cells. Matthew West1,
F. Lamoke1, A. Montemari2, G. Parisi3, G.
Ripandelli3, D. M. Marcus4, M. Bartoli1.
1
Department of Ophthalmology, Georgia Health
Sciences University, Augusta, GA; 2Department of
Experimental Medicine and Pathology, University
of Rome, Rome, Italy; 3IRCCS Fondazione GB
Bietti, Rome, Italy; 4Southeast Retina Center,
Augusta, GA *CR
5001 — A0130 Oxidative Stress-Induced
Necrosis in RPE Cells. Jakub Hanus1, W. C.
Anderson1, P. Jin3, Q. Liu4, S. Wang1, 2. 1Cell
and Molecular Biology, Tulane University, New
Orleans, LA; 2Ophthalmology, Tulane University,
New Orleans, LA; 3Human Genetics, Emory
University, Atlanta, GA; 4Biochemistry, University
of Texas Southwestern Medical Center, Dallas, TX
*CR
4995 — A0124 Conditional ablation of
VEGFR-1 in photoreceptors induces retinal
angiomatous proliferation: A transgenic mouse
model of AMD. Ling Luo1, 2, X. Zhang1, S. K. Das1,
H. Uehara1, T. Miya1, T. Olsen1, B. Archer1, Y.
Fu1, W. Baehr1, B. K. Ambati1. 1Moran eye center,
University of Utah, Salt lake city, UT; 2Department
of Ophthalmology, The 306th hospital of PLA,
China, Beijing, China *CR
4996 — A0125 In-depth analysis of blood
plasma proteome for discovery of age-related
macular degeneration biomarkers. Se Joon
Woo1, 2, H. Kim3, E. Suh3, J. Park1, 2, J. Ahn1, 2,
D. Hwang1, 2, J. Lee3, K. Park1, 2, C. Lee3, 4.
1
Ophthalmology, Seoul National University
College of Medicine, Seoul, Republic of Korea;
2
Ophthalmology, Seoul National University
Bundang Hospital, Seongnam, Republic of Korea;
3
Theragnosis Research Center, Korea Institute of
Science and Technology, Seoul, Republic of Korea;
4
Biomolecular Science, University of Science and
Technology, Daejeon, Republic of Korea
4997 — A0126 Post-Transcriptional Gene
Interactions in Retinal Ischemia. Kalina
Andreeva, M. Soliman, N. G. Cooper. Anatomical
Sciences & Neurobiology, University of Louisville
School of Medicine, Louisville, KY
5002 — A0131 Phosphorylation Networks in
Age-Related Macular Degeneration. Srinivas R.
Sripathi1, O. Sylvester2, T. Moser1, P. S. Bernstein3,
F. Lamoke4, M. Bartoli4, W. Jahng2. 1Biological
Sciences, Michigan Tech University, Houghton,
MI; 2Retina Proteomics Laboratory, Petroleum
Chemistry, American University of Nigeria, Yola,
Nigeria; 3Ophthalmology and Visual Sciences,
Moran Eye Center, University of Utah, Salt Lake
City, UT; 4Ophthalmology, Georgia Health Sciences
University, Augusta, GA *CR
5003 — A0132 Evaluation of RPE cell
senescence as a mechanism for age-related
macular degeneration (AMD),. Michael R.
Kozlowski. Arizona College of Optometry,
Midwestern University, Glendale, AZ
5004 — A0133 An In-Vitro Study of the Effect
of Ultraviolet Radiation on Growth Patterns and
Gene Expression of Human ARPE-19 Cybrid H
and J, and their Implications with Age-related
Macular Degeneration (AMD). Deepika Malik1,
P. Falatoonzadeh1, T. Hsu1, 2, C. A. Ramirez1, J.
Cáceres del Carpio1, M. Mohamed Moustafa1, S.
Jazwinski3, M. V. Michael3, C. M. Kenney1, B. D.
Kuppermann1. 1Ophthalmology, Gavin Herbert
Eye Institute, Irvine, CA; 2Warren Alpert Medical
School, Brown University, Providence, RI; 3Tulane
Center for Aging, Tulane University, New Orleans,
LA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
322
Wednesday – Posters – 5005 – 5027
5005 — A0134 Cybrids with Different mtDNA
Haplogroups Show Differential Expression of
Respiratory Complex Genes. Cristina M. Kenney1,
M. Chwa1, S. Atilano1, P. Falatoonzadeh1, D. Malik1,
C. A. Ramirez1, S. Jazwinski2, M. V. Michael2, B.
D. Kuppermann1. 1Ophthalmology, Gavin Herbert
Eye Inst, UC Irvine, Irvine, CA; 2Tulane Center for
Aging, Tulane University, New Orleans, LA *CR
5006 — A0135 The serine protease HTRA1
is a potential regulator of the inflammatory
cytokine GDF15. Chloe M. Stanton1, E. Kortvely2,
C. Hayward1, M. Ueffing2, 3, A. F. Wright1. 1MRC
Human Genetics Unit, MRC IGMM, University
of Edinburgh, Edinburgh, United Kingdom;
2
Centre for Ophthalmology, Institute for Opthalmic
Research Tubingen, Tubingen, Germany; 3Research
Unit of Protein Science, Helmholtz Zentrum
Munchen, Munich, Germany
5007 — A0136 Role of complement in altered
RPE function and deposit formation in Efemp1
mutant mice: A primary cell culture model.
Rosario Fernandez-Godino, E. A. Pierce, D.
Garland. Ophthalmology, Ocular Genomics
Institute. Mass Eye and Ear Infirmary. Harvard
Medical School, Boston, MA
5008 — A0137 Quantifying progression of
disease in aging mouse and human RPE. John
M. Nickerson1, X. Qi2, T. Jiang3, Y. Cheng3, J. M.
Zhang3, M. A. Chrenek1, A. Rashid1, S. K. Arora1, H.
E. Grossniklaus1, Y. Jiang2. 1Ophthalmology, Emory
Univ, Atlanta, GA; 2Mathematics, Georgia State
University, Atlanta, GA; 3Statistics, Yale University,
New Haven, CT
5009 — A0138 Zinc Staining of subRPE Deposits in Murine Models of Retinal
Degeneration. Rebecca J. Kapphahn1, H.
Roehrich2, D. A. Ferrington1, F. J. van Kuijk1.
1
Ophthalmology, University of Minnesota,
Minneapolis, MN; 2Histology Core for Vision
Research, Universtiy of Minnesota, Minneapolis,
MN
5011 — A0140 The role of Cannabinoid
receptors on light-induced photoreceptor
degeneration. Tomoyo Imamura, Y. Ohno,
K. Tsuruma, M. Shimazawa, H. Hara. Gifu
Pharmaceutical University, Gifu, Japan
5012 — A0141 The involvement of heparinbinding epidermal growth factor like growth
factor on light-induced retinal degeneration.
Yuki Inoue, T. Nakanishi, A. Oyagi, Y. Ohno, T.
Otsuka, K. Tsuruma, M. Shimazawa, H. Hara. Gifu
Pharmaceutical University, Gifu, Japan
5014 — A0143 Inositol phosphatase INPP5E
in primary cilia and eye development. Na Luo1,
M. Conwell1, A. Kumar1, R. M. Anderson2, Y. Sun1.
1
Ophthalmology, Indiana University, Indianapolis,
IN; 2Pediatrics/Endocrinology, Indiana University,
Indianapolis, IN *CR
5015 — A0144 Human Complement Factor
H (CFH) Transgene Expression Rescues the
Visual Function and Retina Abnormalities in
Aged cfh-/- Mice. Jindong Ding1, U. L. Kelly1, M.
Groelle1, C. Bowes Rickman1, 2. 1Ophthalmology,
Duke University Medical Center, Durham, NC;
2
Cell Biology, Duke University Medical Center,
Durham, NC
5016 — A0145 Casein Kinase 1 Epsilon Is
Identified As A Potential Therapuetic Target For
Dry AMD By A Multi-Pronged Gene Expression
Approach. George Inana1, C. Murat1, M. J.
McLaren2. 1Ophthalmology, Bascom Palmer Eye
Institute, Miami, FL; 2Graymatter Research, Miami,
FL *CR
Exhibit Hall A0179-A0204
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Visual Psychophysics / Physiological Optics
467 Visual Functions in AMD
Moderator: Michael D. Crossland
5017 — A0179 Preliminary assessment of a
new device to test potential visual acuity when
compared to gold standard PAM. Elizabeth R.
Richter, J. A. Kylstra. Storm Eye Institute, Medical
University of South Carolina, Charleston, SC *CR,
f
5018 — A0180 Evaluation of vision autotesting in patients with AMD using an iPad App.
Matthias G. Hartmann. Private Practice, Berlin,
Germany *CR
5019 — A0181 A New Contour Integration
Macular Perimetry (CIMP) on iPad for Visual
Function Evaluation in Maculopathy. Yi-Zhong
Wang1, 2, G. Mitzel1. 1Retina Foundation of the
Southwest, Dallas, TX; 2Ophthalmology, UT
Southwestern Medical Center, Dallas, TX *CR
5021 — A0183 Visual Acuity Loss In
Patients With AMD, Measured Using A
Vanishing Optotype Letter Chart. Nilpa
Shah1, R. S. Anderson1, 2, A. Tufail1, C. A. Egan1,
S. Dakin1. 1NIHR Biomedical Research Centre
for Ophthalmology, Moorfields Eye Hospital &
UCL Institute of Ophthalmology, London, United
Kingdom; 2Vision Science Research Group, School
of Biomedical Sciences, University of Ulster at
Coleraine, Northern Ireland, United Kingdom *CR
5022 — A0184 Screening for AMD Using
Psychophysical Correlates of Macular
Dysfunction. Han Li1, S. M. Culican2. 1Washington
University School of Medicine, St. Louis, MO;
2
Dept of Ophthalmology and Visual Science,
Washington University School of Medicine, St.
Louis, MO
5023 — A0185 A New Method to Depict
Central Scotomas: Automated Sterocampimetry.
Anthony P. Cappo1, R. B. Rosen2, W. H. Seiple3, M.
D. Orr1, M. Arthurs4, T. Emborgo5. 1Opticology,
Inc., New York, NY; 2New York Eye & Ear
Infirmary, New York, NY; 3Lighthouse International,
New York, NY; 4Universite de Montreal, Montreal,
QC, Canada; 5Hunter College, City University of
New York, New York, NY *CR
5024 — A0186 Spaeth/Richman Contrast
Sensitivity Test in Macular Degeneration. Bruno
M. Faria, F. Duman, M. Ali, C. Zangalli, S. S.
Wizov, L. Lu, J. Richman, E. Spaeth, G. L. Spaeth.
Glaucoma, Bruno Faria, Philadelphia, PA *CR, f
5025 — A0187 Central And Paracentral
Single-Letter Recognition In Eyes With Macular
Lesions. Gianfrancesco M. Villani1, L. Bertelli1,
G. Sato2, M. U. Morales3, A. Colenbrander4.
1
Ophthalmology, Centro Riabilitazione Ipovedenti e
Microperimetria - CRIM, Castel d’Azzano, Verona,
Italy; 2UO Oftalmologia, Centro Riabilitazione
Visiva, Ospedale S. Antonio, Ulss16, Padova, Italy;
3
Ophthalmology and Visual Sciences, School of
Clinical Sciences, The University of Nottingham,
Nottingham, United Kingdom; 4Smith-Kettlewell
Eye Research Institute, San Francisco, CA *CR
5026 — A0188 Longitudinal Changes in Retinal
Sensitivity among Patients with Maculopathy.
Hongting Liu, M. G. Bittencourt, O. O. Agbedia, A.
Moradi, Y. J. Sepah, D. A. Ferraz, M. A. Ibrahim,
R. Sophie, M. Ansari, Q. Nguyen. Retinal Imaging
Research and Reading Center, Wilmer Eye Institute
Johns Hopkins University, Baltimore, MD *CR
5027 — A0189 Monitoring the Progression
of AMD post anti-VEGF treatment using the
OPKO OCT/SLO. michele arthurs1, R. B. Rosen3,
G. Landa3, R. Weitz3, W. H. Seiple2, 3. 1Université
de Montréal, Montréal, QC, Canada; 2New York
Lighthouse, New York, NY; 3New York Eye & Ear
Infirmary, New York, NY *CR, f
5020 — A0182 myVisionTrack (mVT), a novel
remote visual self-assessment, correlates with
clinical course of macular function. Yu-Guang
He1, J. D. Warminski1, Y. Wang2. 1Ophthalmology,
Univ Texas Southwestern Med Ctr, Dallas, TX;
2
Retina Foundation of the Southwest, Dallas, TX
*CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
323
Wednesday Posters
2:45 pm – 4:30 pm
5010 — A0139 VEGF, VEGF-C, and VEGF-D
Increases in Aqueous Humor Samples in a LPS
Induced Model of Uveitis in New Zealand White
Rabbits. Douglas Decker, J. E. Burr, K. Lester, V.
Zaworski, S. J. Weber. Biochemistry, PharmOptima,
Portage, MI *CR
5013 — A0142 Comparison Study of EFEMP1
Gene Expression Levels in Human ARPE-19
Cybrid Models Having Mitochondrial DNA
of Haplogroups H, J, K or L. Danli Xing1, D.
Malik1, P. Falatoonzadeh1, S. Atilano1, M. Chwa1,
S. Jazwinski2, M. V. Michael2, B. D. Kuppermann1,
C. M. Kenney1. 1Ophthalmology, UC Irvine, Long
Beach, CA; 2Tulane Center for Aging, Tulane
University, New Orleans, LA *CR
5028 – 5049 – Wednesday – Posters
5028 — A0190 Relationship between
Visual Function and Optical Coherence
Tomography features in Early Age-related
macular degeneration (AMD)-Early Markers
Observational Study. Ruth E. Hogg1, G. Murphy1,
G. Staurenghi2, C. Rosina2, R. Silva3, A. Santos3,
U. Chakravarthy1. 1Center for Vision and Vascular
Science, Queen’s University Belfast, Belfast, United
Kingdom; 2Eye Clinic - Department of Clinical
Science, “Luigi Sacco”- Sacco Hospital, II School
of Ophthalmology - University of Milan, Milan,
Italy; 3Faculty of Medicine., University of Coimbra,
Coimbra, Portugal *CR
5029 — A0191 Relationship between retinal
sensitivity and retinal thickness in eyes with
retinal disease. Srinivas R. Sadda, M. Nittala.
Ophthalmology, Doheny Eye Institute - USC, Los
Angeles, CA *CR
5030 — A0192 Multimodal Evaluation of
Macular Function in Age-related Macular
Degeneration. Ken Ogino, A. Tsujikawa, K.
Yamashiro, S. Ooto, A. Oishi, I. Nakata, M. Miyake,
A. Takahashi, A. A. Ellabban, N. Yoshimura. Kyoto
University Graduate School of Medicine, Kyoto,
Japan *CR
5031 — A0193 The functional impact of
subfoveal SD-OCT characteristic on reading
acuity in neovascular age related macular
degeneration. Florian Sulzbacher1, C. G. Kiss1, S.
Sacu1, M. R. Munk1, A. Kaider2, T. Mittermueller1, P.
K. Roberts1, U. Schmidt-Erfurth1. 1Ophthalmology,
Medical University Vienna, Vienna, Austria; 2Center
for Medical Statistics, Informatics, and Intelligent
Systems; Section for Clinical Biometrics;, Medical
University of Vienna, Vienna, Austria *CR
Wednesday Posters
2:45 pm – 4:30 pm
5032 — A0194 Dark-adapted Microperimetry
In Age-related Maculopathy And Geographic
Atrophy. Michael D. Crossland1, 2, R. Ba-Abbad1, 2,
S. Degli Esposti2, A. Tufail2, 3, G. S. Rubin1, 3.
1
UCL Institute of Ophthalmology, London,
United Kingdom; 2Moorfields Eye Hospital NHS
Foundation Trust, London, United Kingdom;
3
NIHR Moorfields Biomedical Research Centre for
Ophthalmology, London, United Kingdom *CR
5033 — A0195 Development of a Dark
Adaptation Protocol for Use in AMD Clinical
Trials. Gregory R. Jackson1, J. G. Edwards2.
1
Ophthalmology, Penn State College of Medicine,
Hershey, PA; 2MacuLogix, Hershey, PA *CR
5034 — A0196 High Angular Resolution
Peripheral Refraction in Patients with Age
Related Macular Degeneration. Bart Jaeken2, 1,
E. Alcón1, 3, J. Marín3, P. Artal1. 1Laboratorio de
Optica, Universidad de Murcia, Murcia, Spain;
2
R&D, Voptica, Murcia, Spain; 3Oftalmología,
Hospital Virgen de la Arrixaca, Murcia, Spain *CR
5037 — A0199 The Influence of Fixation
Stability on Balance in Patients with a Central
Scotoma. Caitlin Murphy1, 4, J. Chu2, E. Landy2,
J. Campbell2, A. Phan2, O. Overbury1, 3. 1School
of Optometry, University of Montreal, Montreal,
QC, Canada; 2Physiotherapy, McGill University,
Montreal, QC, Canada; 3Ophthalmology, McGill
University, Montreal, QC, Canada; 4Centre for
Interdisciplinary Research in Rehabilitation (CRIR),
Montreal, QC, Canada
5038 — A0200 Impact of Visual Motion
Displayed in a Non-Immersive Head-Mounted
Device on the Balance of Patients with AgeRelated Macular Degeneration. Caroline
Chauvire1, C. Cecilia1, A. Koustanai1, J. Le Brun1,
S. Pineau1, T. Villette2, P. Chaumet-Riffaud1, 3,
S. Mohand-Said1, J. A. Sahel1, A. B. Safran1.
1
INSERM, U968; UPMC Univ Paris 06, UMR_S
968, Institut de la Vision; CNRS, UMR_7210;
CHNO des Quinze-Vingts, INSERM-DHOS CIC
503, Paris, France; 2Essilor R&D International,
Paris, France; 3Univ Paris Sud, AP-HP, CHU
Bicêtre, Paris, France *CR
5039 — A0201 Comparing the fixational and
functional preferred retinal locus. Brian Sullivan,
L. Renninger. Smith-Kettlewell Eye Research
Institute, San Francisco, CA
5040 — A0202 Maximum Reading Speed and
Binocular Summation in Patients with Central
Vision Loss. Luminita Tarita-Nistor1, 2, E. G.
Gonzalez1, 2, M. H. Brent3, 4, S. N. Markowitz3, 4, M.
J. Steinbach1, 2. 1Vision Science Research Program,
Toronto Western Hospital, Toronto, ON, Canada;
2
Centre for Vision Research, York University,
Toronto, ON, Canada; 3Ophthalmology and
Vision Sciences, University of Toronto, Toronto,
ON, Canada; 4Ophthalmology, Toronto Western
Hospital, Toronto, ON, Canada
5041 — A0203 Predictive Factors of Reading
Performance Post Reading Rehabilitation
Program in Central Field Loss Patients.
Salvatore Di Lauro, M. B. Coco, A. López-Miguel,
R. Cuadrado, A. Mayo, J. De Lázaro, M. J.
Maldonado, J. Herrera, L. Mena, J. Pastor. RetinaLow Vision, IOBA Eye Institute, University of
Valladolid, Valladolid, Spain *CR
5042 — A0204 Do Pedestrians Make Safe
Street-Crossing Decisions? Shirin E. Hassan.
School of Optometry, Indiana University,
Bloomington, IN
Exhibit Hall B0001-B0033
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Physiology/Pharmacology
468 Drug Delivery III
Moderators: Ashim K. Mitra and
Uday B. Kompella
5043 — B0001 A minimally invasive and
localised intra-scleral delivery of drug-loaded
thermoresponsive polymeric implants to treat
posterior ocular diseases. Hannah L. McMillan,
S. J. Fallows, T. R. Singh, D. S. Jones. School of
Pharmacy, Queen’s University Belfast, Belfast,
United Kingdom *CR
5044 — B0002 Hindered convective transport
of nanoparticles and macromolecules in
the vitreous humor. Anita N. Penkova1, 2, K.
Rattanakijsuntorn1, Y. Tang2, R. Moats2, 3, M. R.
Robinson4, 2, S. S. Lee4, 2, S. S. Sadhal1, 2. 1Aerospace
& Mechanical Engineering, University of Southern
California, Los Angeles, CA; 2SAIRC, Saban
Research Center, Children’s Hospital Los Angeles,
Los Angeles, CA; 3Biomedical Engineering,
University of Southern California, Los Angeles,
CA; 4Global Pharmaceutical Sciences, Allergan,
Inc, Irvine, CA *CR
5045 — B0003 Slow-release intraocular drug
delivery by injectable PEA microfibrils (DSM,
NL). Gabriele Thumann1, G. Mihov2, J. Thies2, A.
Kemp2, K. Morawa1, M. Kropp1. 1Department of
Ophthalmology, University of Geneva, Geneva,
Switzerland; 2DSM, Geleen, Netherlands *CR
5046 — B0004 Fucoidan but not Mannan
inhibits Bevacizumab uptake independently
of phagocytosis and reduces VEGF expression
in the RPE. Michaela Dithmer1, T. Meyer2, 3,
E. Richert1, J. Roider1, A. K. Klettner1.
1
Ophthalmology, University of Kiel, University
Medical Center, Kiel, Germany; 2Immunology,
University of Kiel, University Medical Center, Kiel,
Germany; 3Medizinische Klinik I, Charite-Campus
Benjamin Franklin, Berlin, Germany *CR
5047 — B0005 In Vivo Pharmacokinetics
of Injectable, Intravitreal, Sustained-Release
Latanoprost Formulations. William S. White, M.
Hu, G. Huang, T. Pham, F. Karasina, A. Lee, M.
Gorlina, V. Wong. Icon Bioscience, Inc, Sunnyvale,
CA *CR
5048 — B0006 Hystem, a bio-absorbable
protein delivery polymer: safety, tolerability and
efficacy in a rabbit corneal debridement model.
MaryJane Rafii1, B. M. Wirostko1, 2, L. Werner2, N.
Mamalis2, T. Zarembinski4, S. Pritt3, G. G. Gum3.
1
Ophthalmics, Jade Therapeutics, Salt Lake City,
UT; 2Ophthalmology, University of Utah, SLC, UT;
3
Absorption Systems, SD, CA; 4BioTime, Almeda,
CA *CR
5035 — A0197 Compensation of fixational
instability by the NIDEK MP-1 micro-perimeter.
Arunkumar Krishnan, H. E. Bedell. University of
Houston - College of Optometry, Houston, TX
5036 — A0198 BCEA evaluation after pattern
stimulation in wet AMD patients. Enzo M.
Vingolo, P. G. Limoli, S. Fragiotta, V. De Rosa, D.
Domanico. UOC Ophthal Hosp “SM Goretti” LT,
University La Sapienza of Rome, Roma, Italy
5049 — B0007 Delivery of Human Growth
Hormone via DSM’s Poly(ester amide). Julien
Bérard1, J. Zupancich1, A. Hecka1, G. Mihov1, S.
Reiver1, J. Thies1, K. A. Messier1, B. M. Wirostko2,
M. Rafii2. 1DSM, Geleen, Netherlands; 2Jade
Therapeutics, LLC, Salt Lake City, UT *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
324
Wednesday – Posters – 5050 – 5074
5050 — B0008 Design of a Non-Invasive Coreshell Nanoparticulate Drug Delivery System for
Posterior Part of the Eye. Binapani Mahaling, D.
S. Katti. Biological Sciences and Bioengineering,
Indian Institute of Technology Kanpur, Kanpur,
India
5051 — B0009 Development and
characterization of silicone pressure sensitive
adhesive episcleral implant. He Wen, S. Li.
University of Cincinnati, Cincinnati, OH *CR
5052 — B0010 Ocular injection characteristics
and in vitro release profiles of lipophilic dye
using thermogel PLGA-PE-PLGA as a sustainedrelease drug delivery device. Eva Abarca, P. M.
Potter, J. H. Salmon, B. C. Gilger. North Carolina
State University, Raleigh, NC *CR
5053 — B0011 Development of Aqueous
Nanomicellar Formulation for Topical Delivery
of Biotinylated Lipid Prodrug of Acyclovir to
Treat Herpetic Keratitis. Aswani Dutt Vadlapudi,
K. Cholkar, R. Vadlapatla, A. K. Mitra. Division of
Pharmaceutical Sciences, University of MissouriKansas City, Kansas City, MO
5054 — B0012 Dexamethasone Sustained
Delivery From Polyesteramide Microspheres
For Intraocular Administration. Influence
Of Sterilization. Vanessa Andres-Guerrero1, M.
Zong2, G. Mihov2, A. A. Dias2, R. Herrero-Vanrell1.
1
Pharmaceutical Technology, Faculty of Pharmacy/
Complutense University, Madrid, Spain; 2DSM,
Geleen, Netherlands *CR
5055 — B0013 Pharmacodynamic study
of Intravitreal liposomal doxorubicin by
matrix-assisted laser desorption/ionizationmass spectrometry (MALDI/MS). Hsi-Kung
Kuo, Y. Chen, P. Wu. Ophthalmology, Kaohsiung
Chang Gung Memorial Hospital and Chang Gung
University College of Medicine, Kaohsiung, Taiwan
5056 — B0014 Cavernous Sinus as Ocular
Pharmacokinetic Compartment for Better
Understanding of Posterior Segment and
Contralateral Eye Drug Availability. Muhammad
Abdulrazik. Ophthal/Innovative Interventions, East
Jerusalem Biomedical Institute, East Jerusalem,
Occupied Palestinian Territory
5058 — B0016 Sustained Prednisolone
Acetate-loaded Microfilm Drug Delivery System
Effectively Prolongs corneal allograft survival
in the rat keratoplasty model. Yu-Chi Liu1, 2, Y.
Peng3, N. Lwin1, S. Venkatraman3, T. Wong1, 2, J.
S. Mehta1, 2. 1Singapore Eye Research Institute,
Singapore, Singapore; 2Singapore National Eye
Centre, Singapore, Singapore; 3School of Materials
Science and Engineering, Nanyang Technological
University, Singapore, Singapore *CR
5060 — B0018 Ocular and Systemic
Pharmacokinetics of a PDE4 Inhibitor Following
Topical Administration (Eyedrop) in Male
Dutch-Belted Rabbits. David C. Gale1, C. J.
Sychterz2, C. Rodgers2, S. Wang2, T. Wilde2, A.
Krishnatry2, H. Ellens2. 1Ophthalmology DPU,
GlaxoSmithKline, King of Prussia, PA; 2PTS
DMPK-UM, GlaxoSmithKline, King of Prussia,
PA *CR
5061 — B0019 Aqueous humor concentration
of Bromfenac 0.09% (Bromday) compared with
Bromfenac in DuraSite 0.075% (Bromsite) in
cataract patients undergoing phacoemulsification
after 3 days dosing. Kamran Hosseini1, J.
Hutcheson1, L. M. Bowman2. 1Clinical, InSite Vision
Inc, Alameda, CA; 2Development, InSite Vision,
Alameda, CA *CR, f
5062 — B0020 Comparison of the Total
Amount of Triamcinolone Acetonide
Delivered Via Suprachoroidal or Intravitreal
Administration. Brian Burke, R. S. Verhoeven, S.
R. Patel. Clearside Biomedical, Raleigh, NC *CR
5063 — B0021 Suprachoroidal Microinjection
Delivers Triamcinolone Acetonide to
Therapeutically-Relevant Posterior Ocular
Structures and Limits Exposure in the Anterior
Segment. Henry F. Edelhauser1, 2, S. R. Patel2, C.
Meschter3, R. Dean3, K. Powell4, R. S. Verhoeven2.
1
Ophthalmology, Emory Univ Eye Center,
Atlanta, GA; 2Clearside Biomedical, Alpharetta,
GA; 3Comparative Biosciences, Sunnyvale, CA;
4
Tandem Labs, Durham, NC *CR
5064 — B0022 Protective Effects of
Transscleral Drug Delivery Device Against
Photoreceptor Cell Death in S334ter Rhodopsin
Mutant Rats. Nobuhiro Nagai1, H. Kaji2, H.
Onami1, T. Yamada2, Y. Katsukura1, Y. Ishikawa1,
M. Nishizawa2, Y. Mashima3, T. Abe1. 1Graduate
School of Medicine, Tohoku University, Sendai,
Japan; 2Graduate School of Engineering, Tohoku
University, Sendai, Japan; 3R-Tech Ueno, Tokyo,
Japan *CR
5065 — B0023 In vitro cytotoxicity screening
and pharmacokinetic modeling: a tool in the
development of ocular drug delivery systems.
Eva Tuominen1, G. Mihov2, M. Zong2, S. Sarkhel1,
A. A. Dias2, A. Urtti1. 1Centre for Drug Research,
Faculty of Pharmacy, University of Helsinki,
Helsinki, Finland; 2DSM, Geleen, Netherlands *CR
5066 — B0024 Retinal Safety and Efficacy of
a Dexamethasone Biodegradable Implant to
Treat Macular Edema Associated to Retinal Vein
Occlusion: A Phase I/II Clinical Trial. Rubens C.
Siqueira1, R. B. Cunha1, A. Messias1, A. S. Cunha2,
S. Fialho2, R. Jorge1. 1Retina, Sao Paulo University,
Sao Jose do Rio Preto, Brazil; 2Pharmacology,
Minas Gerais Federal University, Belo Horizonte,
Brazil f
5067 — B0025 Therapeutic effect of
stealth-type polymeric nanoparticles with
encapsulated cyclosporine A on experimental
autoimmune uveoretinitis. Tsutomu Sakai1, K.
Kuroyanagi1, T. Ishihara2, K. Okano1, H. Tsuneoka1.
1
Ophthalmology, Jikei Univ School of Medicine,
Setagaya-ku, Japan; 2Chemical biology and applied
chemistry, Nihon university college of engineering,
Kooriyama, Japan
5068 — B0026 Development of an in vitro
pharmacokinetic model of the human eye.
Sahar Awwad1, 2, A. Lockwood1, 2, A. Mohamed
Ahmed1, 2, G. Sharma1, 2, A. Khalili2, S. Brocchini1, 2,
P. T. Khaw2. 1UCL School of Pharmacy, London,
United Kingdom; 2National Institute for Health
Research (NIHR) Biomedical Research Centre at
Moorfields Eye Hospital NHS Foundation Trust and
UCL Institute of Ophthalmology, London, United
Kingdom *CR
5069 — B0027 Tunable sustained intravitreal
drug delivery system for daunorubicin using
oxidized porous silicon. Huiyuan Hou1, A.
Nieto2, F. Ma1, S. Lee1, K. Nan1, W. R. Freeman1,
M. J. Sailor2, 3, L. Cheng1. 1Department of
Ophthalmology, Shiley Eye Center, UCSD,
San Diego, CA; 2Department of Chemistry and
Biochemistry, UCSD, San Diego, CA; 3Department
of Bioengineering, UCSD, San Diego, CA *CR
5070 — B0028 3D Computational Fluid
Dynamic Simulation of an Intravitreal
Brimonidine Implant in the Rabbit Eye. Julie
E. Whitcomb1, S. S. Lee2, B. D. Swift1, J. Rowe3,
M. R. Kazemi4, J. Shen1. 1Pharmacokinetics
& Drug Disposition, Allergan, Irvine, CA;
2
Ophthalmology Clinical Research, Allergan, Irvine,
CA; 3Bioanalytical Sciences, Allergan, Irvine, CA;
4
Independent Engineer Consultant, San Jose, CA
*CR
5071 — B0029 Optimization of In-vitro
DiffER model to study/compare the effect
of Formulations on Cross-Scleral transport
of poorly aqueous soluble drug. Thomas E.
Rowe1, K. W. Reed2, 1, T. Bhowmik1. 1Encompass
Pharmaceutical Services, Norcross, GA;
2
Pharmaceutical Sciences, Belmont University,
Nashville, TN *CR
5072 — B0030 Ocular bioavailability of
brimonidine 0.1% BID in non-human primates.
Chinatsu Tosha, S. Decker, G. Ruiz, O. Avalos, W.
Orilla, L. Gruber, T. Lin, A. S. Almazan, D. W. Gil,
J. A. Burke. Biological Science, Allergan, Inc.,
Irvine, CA *CR
5073 — B0031 Sustained Delivery of
Prostaglandin from Drug-Containing Depots
Using Ocular Rings in Beagles. Kathryn S.
Crawford1, J. Y. Ellis2, J. Rulander3, S. Johnston3,
F. S. Lai3, E. J. Ellis2, C. D. Leahy2. 1PharmOcu,
Andover, MA; 2Vista Scientific, LLC, Andover,
MA; 3Massachusetts Medical Device Development
Center, University of Massachusetts, Lowell, MA
*CR
5074 — B0032 Evaluating & Predicting Drug
Release from an Implantable Biomaterial. Ivana
Postic, H. Sheardown. Chemical Engineering,
McMaster University, Hamilton, ON, Canada *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
325
Wednesday Posters
2:45 pm – 4:30 pm
5057 — B0015 Influence of Physicochemical
Properties on Drug Delivery across Sclera into
Choroid-Retina. Ayumi Yoshimatsu1, C. Yabuta1,
A. Ohtori1, 2, M. Azuma1. 1Senju Laboratory of
Ocular Sciences, Senju Pharmaceutical Co., Ltd.,
Kobe, Japan; 2Laboratory of Ocular Drug Delivery
System, Kyushu Institute of Technology, Fukuoka,
Japan *CR
5059 — B0017 Treatment of Acute Posterior
Uveitis by Injection of Triamcinolone
Acetonide into the Suprachoroidal Space Using
Microneedles. Brian C. Gilger1, E. M. Abarca1, J.
H. Salmon1, S. R. Patel2. 1Clinical Sciences, North
Carolina State University, Raleigh, NC; 2Clearside
Biomedical, Alpharetta, GA *CR
5075 – 5094 – Wednesday – Posters
5075 — B0033 A hollow metal microneedle
reduce reflux in intravitreal injections. SungHo
Lee1, D. Lee2, Y. You2, S. Kim2, C. Lee3, H. Jung3, S.
Lee4, O. Kwon2. 1R&D Center, Lumieye Genetics
Co., Ltd., Seoul, Republic of Korea; 2Retina center,
NUNE Eye Hospital, Seoul, Republic of Korea;
3
Biotechnology, Yonsei University, Seoul, Republic
of Korea; 4Ophthalmology, Soonchunhyang
University Hospital, Seoul, Republic of Korea
Exhibit Hall B0034-B0058
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Visual Neuroscience
469 Dysfunction in Disease:
Translational Studies
Moderator: Erika D. Eggers
5076 — B0034 Evidence Suggesting Retinotopic
and Age Variability in Rate of Photoreceptor
Loss Following Bright Light Exposure in
Neonatal Rats. Anna Polosa, P. Lachapelle.
Ophthalmology/Neurology-Neurosurgery, McGill
University/Montreal Children’s Hospital, Montreal,
QC, Canada
5077 — B0035 Neonatal Hypoxia-Ischemia
Retinopathy: Severity at Onset Determines
Fate. Suna Jung1, 2, A. Polosa2, P. Lachapelle2,
P. Wintermark1. 1Newborn Medicine, Montreal
Children’s Hospital, Montreal, QC, Canada;
2
Ophthalmology and Neurology-Neurosurgery,
Research Institute of Montreal Children’s Hospital,
McGill University, Montreal, QC, Canada
Wednesday Posters
2:45 pm – 4:30 pm
5078 — B0036 Oxidative-Retinopathies:
Female Neonate Rats Handle Bright Light
Better Than Hyperoxia, Males React Strongly
To Both. Samaneh Chaychi1, S. Chorfi1, A. Polosa1,
S. Jung1, A. L. Dorfman1, X. Yang1, S. Chemtob2,
P. Lachapelle1. 1Ophthalmology-Neurology/
Neurosurgery, McGill Univ/Montreal Children’s
Hosp, Montreal, QC, Canada; 2Pharmacology,
McGill Univ/Montreal Children’s Hosp, Montreal,
QC, Canada
5079 — B0037 Effects of vitamin A on a rat
model of retinopathy of prematurity (ROP). Julie
A. Mocko1, Y. Wei2, L. J. Frishman1, X. I. Couroucli2.
1
College of Optometry, University of Houston,
Houston, TX; 2Section of Neonatology, Department
of Pediatrics, Baylor College of Medicine, Houston,
TX
5080 — B0038 Scotopic Spatial Summation
in Retinopathy of Prematurity (ROP). Jena
Tavormina1, 2, R. M. Hansen1, 2, A. Moskowitz1, 2, A.
B. Fulton1, 2. 1Ophthalmology, Boston Children’s
Hospital, Boston, MA; 2Harvard Medical School,
Boston, MA
5081 — B0039 Activation of Pannexin1
channel induces ganglion cell loss in retinal
ischemia. Valery I. Shestopalov1, 2, A. Toychiev3,
G. Dvoriantchikova1, C. Yee3, A. Pronin1, 4, V. Z.
Slepak4, B. T. Sagdullaev3, 5. 1Bascom Palmer Eye
Institute Dept. Ophthalmology, University of Miami
Miller School of Medicine, Miami, FL; 2Vavilov
Institute of General Genetics, Moscow, Russian
Federation; 3Ophthalmology, Weill Medical College
of Cornell University, White Plains, NY; 4Molecular
Pharmacology, University of Miami Miller School
of Medicine, Miami, FL; 5Winifred Masterson
Burke Medical Research Institute, White Plains, NY
5082 — B0040 Over-Expression of Dystrophin
Isoform Dp71 Does Not Alter the Mouse ERG.
De-Ann M. Pillers1, 2, W. Luo1, S. A. Tokarz1, P. N.
Ray4, B. R. Pattnaik1, 3. 1Department of Pediatrics,
University of Wisconsin-Madison, Madison, WI;
2
McPherson Eye Research Institute, University of
Wisconsin, Madison, WI; 3Ophthalmology & Visual
Science, University of Wisconsin, Madison, WI;
4
Hospital for Sick Children, University of Toronto,
Toronto, ON, Canada
5083 — B0041 Reduction of ERG Amplitude
during light adaptation in Pikachurin nullmutant mice. Masatoshi Nagaya1, S. Ueno1, M.
Kondo2, T. Furukawa3, H. Terasaki1. 1Nagoya
University, Nagoya, Japan; 2Mie Univ Graduate
School of Med, Tsu, Japan; 3Institute for Protein
Research, Osaka & JST, CREST, Osaka, Japan
5084 — B0042 Alterations in the mGluR6
signaling complex in the retina of mdx3Cv mice,
a model of Duchenne Muscular Disease. Michel
J. Roux1, A. Philipps1, C. Chapot1, J. A. Sahel2, 3, A.
Rendon2. 1Translational Medicine & Neurogenetics,
IGBMC, CNRS UMR7104 - Université de
Strasbourg, Inserm U964, Illkirch, France;
2
Institut de la Vision, Inserm UMR_S968, CNRS
UMR_7210, Université Pierre et Marie Curie
Paris 06, Paris, France; 3Centre d’Investigation
Clinique 503, Inserm-Centre Hospitalier National
d’Ophtalmologie des Quinze-Vingts, Paris, France
*CR
5085 — B0043 Evaluation of retinal and optic
nerve stress in Wfs1-/- mouse model of Wolfram
syndrome. Delphine M. Bonnet Wersinger1, C. P.
Hamel1, Y. Tanizawa2, G. Lenaers1, C. Delettre1.
1
Montpellier Neuroscience Institute, INSERM
U1051, Montpellier, France; 2Center for Reparative
Medicine Graduate School of Medicine, Yamaguchi
University, Yamaguchi, Japan
5086 — B0044 Impaired Functional
Connectivity in the Visual Pathway in Monkeys
Deficient in Omega-3 Fatty Acids. Martha
Neuringer1, D. S. Grayson2, C. D. Kroenke1, 3, L.
Renner1, A. R. Weiss1, D. A. Fair2, 3. 1Neuroscience,
Oregon National Primate Research Center,
Beaverton, OR; 2Behavioral Neuroscience,
Oregon Health & Science University, Portland,
OR; 3Advanced Imaging Research Center, Oregon
Health & Science University, Portland, OR *CR
5087 — B0045 A novel knock-in model for
the Y141C pattern dystrophy mutation in RDS.
Michael Stuck, S. M. Conley, M. I. Naash. Univ of
Oklahoma Hlth Sci Ctr, Oklahoma City, OK
5088 — B0046 Elucidation of
physiopathological mechanisms of GPR179.
Elise Orhan1, L. Prezeau5, C. Michiels1, C. Vol5,
J. A. Sahel2, 3, I. S. Audo4, 3, C. Zeitz1. 1Institut de
la Vision, Univ Pierre et Marie Curie Paris 6,
INSERM, UMR_S968; CNRS, UMR_7210, Paris ,
F-75012, France; 2Univ Pierre et Marie Curie Paris
6, INSERM, UMR_S968; CNRS, UMR_7210;
CHNO, INSERM-DHOS CIC 503; Fondation
Ophtalmologique Adolphe de Rothschild, Paris;
Académie des Sciences-Institut de France, Paris ,
F-75012, France; 3UCL-Institute of Ophthalmology,
11-43 Bath Street, London EC1V 9EL, United
Kingdom; 4Univ Pierre et Marie Curie Paris 6,
INSERM, UMR_S968; CNRS, UMR_7210;
CHNO, INSERM-DHOS CIC 503, Paris , F-75012,
France; 5Institut de Génomique Fonctionnelle
CNRS UMR5203, INSERM U661, UM1 & UM2,
Montpellier, France *CR
5089 — B0047 Dry Eye and Headache Mouse
Clinical Models of Photophobia. Anna Matynia1, 2,
S. Parikh1, 2, A. Charles2, 3, M. B. Gorin1, 2. 1Jules
Stein Eye Institute, UCLA, Los Angeles, CA;
2
Brain Research Institute, UCLA, Los Angeles, CA;
3
Neurology, UCLA, Los Angeles, CA *CR
5090 — B0048 Intravitreal injection of
acyclovir causes dose-related retinal toxicity in
rabbits. Gabriela L. Ioshimoto1, B. Takahashi2, C.
N. Pessoa3, A. M. Liber1, B. V. Nagy1, D. F. Ventura1,
F. Damico2. 1Department Experimental Psychology,
Psychology Institute, University of Sao Paulo, São
Paulo, Brazil; 2Department of Ophthalmology,
University of Sao Paulo, Sāo Paulo, Brazil;
3
Department of Cell and Developmental Biology,
Biomedical Sciences Institute, University of Sao
Paulo, São Paulo, Brazil
5091 — B0049 Retinal Degeneration in the
Royal College of Surgeons Rat - A Study on
Electrophysiological Properties. Stephan Hesse1,
C. Haselier1, S. Johnen1, T. Baltz2, G. Roessler1,
B. A. Mazinani1, P. Walter1. 1Department of
Ophthalmology, RWTH Aachen University, Aachen,
Germany; 2Department of Technical Science and
Business Development, University of Erfurt, Erfurt,
Germany *CR
5092 — B0050 Light-evoked Response
Recordings from Degenerating Mouse
Retina: Effect of Valproic Acid Application on
Spontaneous Activity. Jun Kaneko, M. Mandai, M.
Takahashi. Lab for Retinal Regeneration, RIKEN
Ctr for Developmental Biol, Kobe, Japan
5093 — B0051 Retinal Inhibitory Signaling is
Increased in Streptozotocin-induced Diabetes.
Johnnie Moore-Dotson1, R. Mazade1, A. S.
Berstein1, 2, M. J. Romero-Aleshire1, H. Brooks1, E.
D. Eggers1, 2. 1Physiology, University of Arizona,
Tucson, AZ; 2Biomedical Engineering, University
of Arizona, Tucson, AZ
5094 — B0052 The retinal phenotype of an
animal model of the HANAC syndrome. Alix
Trouillet1, E. Plaisier2, H. Lorach1, J. Dégardin1, M.
Simonutti1, M. Paques1, J. A. Sahel1, P. Ronco2, S.
A. Picaud1. 1Institut de la Vision, INSERM/CNRS/
UPMC/CHNO des XV-XX, Paris, France; 2APHPHôpital Tenon, Paris, France *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
326
Wednesday – Posters – 5095 – 5112
5095 — B0053 Visual Deficits in Mice after
Mild Traumatic Brain Injury Produced using
A Novel Closed-head Model of Primary
Overpressure Blast. Tonia S. Rex1, A. J. Elberger2,
Y. Deng2, N. H. Guley2, J. Hines-Beard1, L.
D’Surney2, 3, N. Del Mar2, M. G. Honig2, A.
Reiner2, 3. 1Ophthalmology & Visual Sciences,
Vanderbilt University, Nashville, TN; 2Anatomy
& Neurobiology, University of Tennessee Health
Science Center, Memphis, TN; 3Ophthalmology,
University of Tennessee Health Science Center,
Memphis, TN *CR
5096 — B0054 Morphological and Functional
Study of Retinal Astrocytes in DBA/2J Mice.
Laura Fernandez-Sanchez1, L. Perez de Sevilla
Muller2, N. Brecha2, 3, N. Cuenca1. 1Physiology,
Genetics & Microbiology, University of Alicante,
Alicante, Spain; 2Neurobiology, David Geffen
School of Medicine at UCLA, Los Angeles, CA;
3
Veterans Administration, Greater Los Angeles
Healthcare System, Los Angeles, CA *CR
5097 — B0055 Axonal Transport Disruption
in Retinal Ganglion Cells Following Transient
Increase in Intraocular Pressure. Andrea C.
Nuschke1, 2, X. Wang1, 2, N. O’Leary1, 3, C. A.
Smith1, 2, B. C. Chauhan1, 3. 1Retina and Optic Nerve
Research Laboratory, Dalhousie University, Halifax,
NS, Canada; 2Physiology and Biophysics, Dalhousie
University, Halifax, NS, Canada; 3Ophthalmology
and Visual Sciences, Dalhousie University, Halifax,
NS, Canada
5098 — B0056 VLC-PUFA and the scotopic
photoresponse. Lea D. Marchette1, R. A. Radu2, R.
E. Anderson1. 1Ophthalmology, Univ of Oklahoma
Hlth Sci Ctr, Oklahoma City, OK; 2UCLA, Los
Angeles, CA *CR
5099 — B0057 Implantation of a highdensity, flexible CMOS imaging sensor retinal
prosthesis in minipig eyes. Chang-Hao Yang1,
L. Fan2, F. Yang2. 1Ophthalmology, National
Taiwan Univ Hospital, Taipei, Taiwan; 2Institute
of NanoEngineering and Microsystems, National
Tsing-Hua University, Hsinchu, Taiwan *CR
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Visual Neuroscience
470 Dysfunction in Disease:
Clinical Studies
Moderator: Carol A. Westall
5101 — B0059 Wide field imaging in patients
treated with vigabatrin. Catherine Brugniart1,
J. Bursztyn2, J. Motte3, A. Ducasse1, C. F. Arndt1.
1
Ophtalmologie, CHU Reims, Reims, France;
2
Cabinet Ophtalmologie, Paris, France; 3American
Memorial Hospital, Reims University Hospital,
Reims, France *CR
5102 — B0060 Association Between ERG
Associated Vigabatin Toxicity and Subsequent
Visual Field Reduction. Ananthavalli
Kumarappah1, 2, Y. Reginald2, J. Buncic2, O.
Snead3, C. A. Westall1, 2. 1Institute of Medical
Sciences, University of Toronto, Toronto, ON,
Canada; 2Ophthalmology and Vison Sciences, The
Hospital for Sick Children, Toronto, ON, Canada;
3
Neurology, The Hospital for Sick Children,
Toronto, ON, Canada *CR
5103 — B0061 Electroretinograms Ordered
for Vigabatrin Use at the Children’s Hospital
Colorado. Ashley E. Laing1, J. L. Jung1, E. A.
McCourt1, 2, R. S. Braverman1, 2. 1Ophthalmology,
University of Colorado, Denver, CO;
2
Ophthalmology, Children’s Hospital of Colorado,
Aurora, CO
5104 — B0062 Absence of the cone-mediated
OP3 associated with Vigabatrin therapy. Julie
Racine, R. Noles, J. R. Hickox, M. McGregor, D.
L. Rogers. Ophthalmology, Nationwide Children’s
Hospital, Columbus, OH
5105 — B0063 The utility of multifocal
electroretinography (mfERG) in screening
for hydroxychloroquine/chloroquine induced
retinopathy. Kevin Leonard, J. Gao, J. Hamilton,
C. Gottlieb, S. G. Coupland. University of Ottawa
Eye Institute, Ottawa, ON, Canada *CR
5106 — B0064 Follow-up of patients affected
by rheumathoid arthritis and connectivities,
under therapy with hydroxychloroquine or
chloroquine via multifocal electroretinogram,
frequency doubling technology, automated
perimetry, optical coherence tomography and
autofluorescence. Giulio Ruberto1, L. Cavagna2,
C. Tinelli3, M. Raimondi1, V. Mogavero1, P.
Piccinini1, F. Borgaro1, L. Bossolesi1. 1Clinica
Oculistica, IRCCS Policlinico San Matteo, Pavia,
Italy; 2reumatologia, IRCCS Policlinico San
Matteo, Pavia, Italy; 3Servizio di biometria, IRCCS
Policlinico San Matteo, Pavia, Italy
5107 — B0065 Evaluation of Inner Retinal
Changes using Macular Focal Electroretinogram
and Optical Coherence Tomography in Patients
with Early Stage Diabetes. Manami Kuze1, 2, T.
Tanaka3, H. Goto3, M. Kondo2. 1Ophthalmology,
NHO Mie Chuo Medical Center, Tsu, Japan;
2
Ophthalmology, Mie University School of
Medicine, Tsu, Japan; 3Internal Medicine, NHO Mie
Chuo Medical Center, Tsu, Japan
5108 — B0066 Relation between the fast
oscillation of the EOG and ERG measures of
rod photoreceptor function in healthy eyes and
in diabetes. Marilyn E. Schneck, W. A. Verdon, W.
Lam, K. P. Dhamdhere, T. Zeng, S. Barez, M. A.
Bearse, A. J. Adams. School of Optometry-2020,
UC Berkeley, Berkeley, CA
5109 — B0067 PRPH2 Mutations as a Cause
of Electronegative ERG. Rola Ba-Abbad3, 1, A. G.
Robson1, 4, A. T. Moore4, 2, A. R. Webster4, 2, Y. Yap2,
G. E. Holder1, 3. 1Electrophysiology, Moorfields
Eye Hospital, London, United Kingdom; 2Medical
Retina & Genetics, Moorfields Eye Hospital,
London, United Kingdom; 3Visual Neuroscience,
Institute of Ophthalmology, London, United
Kingdom; 4Genetics, Institute of Ophthalmology,
London, United Kingdom *CR
5110 — B0068 Long-Term Decay of Central
Cone Function in Cone-Rod Dystrophy
Evaluated by Focal Electroretinogram. Benedetto
Falsini1, M. Piccardi1, L. Ziccardi2, A. Fadda4, A.
M. Minnella1, D. Marangoni1, S. Bisti6, G. Resta5, L.
Galli Resta3. 1Ophthalmology, Universita’ Cattolica
del S. Cuore, Rome, Italy; 2Ophthalmology, Bietti
Foundation IRCCS, Rome, Italy; 3Neuroscience
Institute, CNR, Pisa, Italy; 4Health and Technology,
Istituto Superiore di Sanita, Rome, Italy;
5
Informatics and Telematics, CNR, Pisa, Italy;
6
Scienze Cliniche ed Applicate Biotecnologiche,
Universita dell’Aquila, L’Aquila, Italy
5111 — B0069 Blue-on-yellow
electroretinography on patients with enhanced
S-cone syndrome. Kazuki Kuniyoshi1, T. Hayashi2,
H. Sakuramoto1, H. Tsuneoka2, Y. Shimomura1.
1
Ophthalmology, Kinki University Faculty of
Medicine, Osaka-sayama, Japan; 2Ophthalmology,
The Jikei University School of Medicine, Tokyo,
Japan
5112 — B0070 Chromatic Full-field Stimulus
Threshold (FST) in Retinitis Pigmentosa Relationships with electroretinography and
visual field outcomes. Andre Messias, K. Messias,
R. S. Arcieri, V. M. Castro, R. C. Siqueira, R. Jorge.
Ophthalmology, University of Sao Paulo, Ribeirao
Preto, Brazil
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
327
Wednesday Posters
2:45 pm – 4:30 pm
5100 — B0058 Development and Evaluation
of Highly Light-Sensitive Channelrhodopsin-2
Mutants for Vision Restoration. Zhuo-Hua
Pan, T. Ganjawala, Z. Zhang, Q. Lu, E. Ivanova.
Ophthalmology and Anatomy & Cell Biology,
Wayne State Univ Sch of Med, Detroit, MI *CR
Exhibit Hall B0059-B0091
5113 – 5133 – Wednesday – Posters
5113 — B0071 Microvolt Cone
Electroretinography in Type 1 and 2 Usher
Syndrome. Wadih M. Zein1, E. T. Tsilou1, A.
E. Turriff1, J. M. Schultz3, J. A. Muskett4, C.
C. Brewer4, C. K. Zalewski4, K. A. King4, P. A.
Sieving2, 5, B. Falsini1, 6. 1Ophthalmic Genetics
& Visual Function, NEI/NIH, Bethesda, MD;
2
National Eye Institute/NIH, Bethesda, MD;
3
Laboratory of Molecular Genetics, National
Institute on Deafness and Other Communication
Disorders (NIDCD)/NIH, Rockville, MD;
4
Otolaryngology Branch, National Institute on
Deafness and Other Communication Disorders
(NIDCD)/NIH, Rockville, MD; 5National Institute
on Deafness and Other Communication Disorders
(NIDCD)/NIH, Rockville, MD; 6Ophthalmology,
Catholic University of Sacred Heart, Rome, Italy f
5114 — B0072 Population receptive field
estimates in V1 lesion projection zone of
patients with macular degeneration onset at
different ages. Yoichiro Masuda1, 2, M. Terao3, T.
Haji4, K. Amano5, 6, H. Horiguchi1, 7, S. Ogawa1, 7,
I. Murakami3, K. Matsumoto4, H. Tsuneoka1, B.
Wandell7. 1Ophthalmology, Jikei Univ School of
Med, Tokyo, Japan; 2Ophthalmology, Atsugi City
Hospital, Kanagawa, Japan; 3Department of Life
Sciences, The University of Tokyo, Tokyo, Japan;
4
Brain Science Institute, Tamagawa University,
Tokyo, Japan; 5Graduate School of Frontier
Sciences, The University of Tokyo, Tokyo, Japan;
6
PRESTO, Japan Science and Technology Agency,
Tokyo, Japan; 7Psychology, Stanford University,
Stanford, CA
Wednesday Posters
2:45 pm – 4:30 pm
5115 — B0073 Visual Function Effects of
Foretinib, a Dual MET/VEGFR2 Inhibitor,
in a Phase 2 Study for Treatment of Papillary
Renal Cell Carcinoma. Catherine Meyerle1, R.
Srinivasan2, W. Linehan2, S. Yeh1, E. Y. Chew1, C.
Chan1, F. Forooghian1, F. L. Ferris1, W. M. Zein1.
1
National Eye Institute, Bethesda, MD; 2National
Cancer Institute, Bethesda, MD *CR, f
5116 — B0074 Anatomical Locus of Spatial
Summation within the Retina and Neuroretinal
Disease. Katherine Boudreault1, L. A. Levin2, 3.
1
Ophthalmology, University of Montreal, Montreal,
QC, Canada; 2Ophthalmology, McGill University,
Montreal, QC, Canada; 3Ophtalmology, University
of Wisconsin, Madison, WI *CR
5117 — B0075 Combined Systemic Health
Markers are Associated with Multifocal
Electroretinogram Implicit Times in Healthy
Subjects with no Eye Disease. Wendy W.
Harrison, V. Yevseyenkov, C. Sorenson. Optometry,
Midwestern Univ Arizona Coll of Optometry,
Glendale, AZ
5118 — B0076 Differences in neuroretinal
function between healthy adult males and
females under and over the age of 50 years.
Glen Y. Ozawa1, M. A. Bearse1, W. W. Harrison2,
K. W. Bronson-Castain1, M. E. Schneck1, S. Barez1,
K. P. Dhamdhere1, B. E. Wolff1, A. J. Adams1.
1
UC Berkeley School of Optometry, Berkeley,
CA; 2Midwestern University Arizona College of
Optometry, Glendale, AZ
5119 — B0077 Analysis of electroretinograms
performed from 2009 to 2011 at Children’s
Hospital Colorado. Jennifer L. Jung1, A. E.
Laing1, E. A. McCourt2, 1, R. S. Braverman2, 1.
1
Ophthalmology, University of Colorado, Aurora,
CO; 2Ophthalmology, Children’s Hospital Colorado,
Aurora, CO
5127 — B0085 ERG as Indicator of Retinal
Function in Persistent Fetal Vasculature. Brian
Do1, J. H. Francis2, B. Marr2, D. H. Abramson2,
S. E. Brodie1, 2. 1Ophthalmology, The Mount Sinai
School of Medicine, New York, NY; 2Ophthalmic
Oncology, Memorial Sloan Kettering Cancer
Center, New York, NY
5120 — B0078 Electroretinographic assessment
of retinal function at high altitude. Andreas
Schatz1, G. Willmann1, M. Fischer1, 2, K. Schommer3,
A. Messias4, E. Zrenner1, K. Bartz-Schmidt1, F.
Gekeler1. 1Centre for Ophthalmology, University
of Tuebingen, Tuebingen, Germany; 2Department
of Clinical Neurosciences, University of Oxford,
Oxford, United Kingdom; 3Department of Sports
Medicine, University of Heidelberg, Heidelberg,
Germany; 4Department of Ophthalmology, School
of Medicine of Ribeirão Preto-University of São
Paulo, São Paulo, Brazil *CR
5128 — B0086 Electrophysiological Test for
the Assessment of Dysfunction in Glaucoma.
Momoyo K. Menz, M. G. Fendick, E. E. Sutter.
Electrophysiology Laboratory, Electro-Diagnostic
Imaging, Inc, Redwood City, CA *CR
5121 — B0079 Unilateral Post Operative Visual
Loss with Total Ophthalmoplegia due to central
retinal artery occlusion following Cervical Spine
surgery in Prone Position. Vishal Jindal1, A. Raj1,
D. Kapoor2. 1Ophthalmology, GMCH, Chandigarh,
India; 2Anesthesia, GMCH, Chandigarh, India
5122 — B0080 A study on visual status
in children with autistic spectral disease at
Shraddha Center in Hyderabad City. Shata
Roopa Reddy Pebbeti1, 2, K. Challa1, G. D. Vatti1,
P. Jagana1, G. K. Vemuganti1. 1School of Medical
Sciences, University of Hyderabad, Hyderabad,
India; 2Brienholden Vision Institute, University of
New South Wales, Sydney, NSW, Australia
5123 — B0081 Prognostic Value of Photopic
Negative Response in Retinal Vein Occlusion
after Anti-VEGF treatment. Tae Kwann
Park, J. Hyun, S. An, Y. Ohn. Ophthalmology,
Soonchunhyang Univ Hospital, Bucheon-si,
Republic of Korea
5124 — B0082 Electronretinogram and
aqueous vascular endotheril growth factor in
the eyes with hemi-central retinal vein occlusion
or branch retinal vein occlusion. Shu Kachi, S.
Yasuda, H. Ushida, M. Kondo, S. Ueno, C. Piao,
H. Terasaki. Ophthalmology, Nagoya University,
Nagoya, Japan
5125 — B0083 Central retina vein occlusion
and diabetic retinopathy treated with intravitreal
dexamethasone and bevacizumab: a morphofunctional analysis. Sara Lombardo, M. Imparato,
G. Ruberto, V. Mogavero, L. Giannì, F. Marzi, A.
Amisano, A. Bianchi, P. Bianchi, G. Vandelli. Eye
Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
5126 — B0084 Retinal blood flow levels
measured by Laser Speckle Flowgraphy in
central retinal vein occlusion as a predictive
factor for ischemia and visual loss. Makiko
Matsumoto, K. Suzuma, Y. Yamada, E. Tsuiki, A.
Fujikawa, T. Kitaoka. Ophthalmology, Department
of Ophthalmology and Visual Sciences, Graduate
School of Biomedical Sciences, Nagasaki
University, Nagasaki, Japan
5129 — B0087 Relationship between amplitude
of N2 of multifocal electroretinograms and
retinal sensitivity in unilateral glaucoma
patients. Gen Miura, S. Shirato, S. Yamamoto.
Chiba university, Chiba, Japan
5130 — B0088 Alteration of Photopic Negative
Response of Multifocal Electroretinogram in
Patients with Glaucoma. Muneyoshi Kaneko,
S. Machida, Y. Hoshi, D. Kurosaka. Department
of Ophthalmology, Iwate Medical University,
Morioka, Japan
5131 — B0089 Reproducibility of Multifocal
Visual Evoked Potential (mfVEP) in Normal and
Multiple Sclerosis (MS) Eyes. Divya Narayanan,
H. Cheng, R. Tang, L. J. Frishman. Optometry,
University of Houston, Houston, TX *CR
5132 — B0090 Rates of Reliable Multifocal
Visual Evoked Potential Waveforms:
Comparison Between Multiple Sclerosis and
Neuromyelitis Optica Patients. Lorena B. Botelho
Vergara1, 2, P. A. Paixao1, 2, L. A. Fernandes1, 2,
E. C. Lacerda2, 3, G. S. Souza2, 3, A. L. Moura4,
D. F. Ventura4, H. Souza Cabeça5, A. A. Rosa2, 6,
L. L. Silveira2. 1Instituto de Ciencias da Saude,
Universidade Federal do Para, Belem, Brazil;
2
Nucleo de Medicina Tropical, Universidade Federal
do Para, Belem, Brazil; 3Instituto de Ciencias
Biologicas, Universidade Federal do Para, Belem,
Brazil; 4Instituto de Psicologia, Universidade de
Sao Paulo, Belem, Brazil; 5Hospital Ophyr Loiola,
Belem, Brazil; 6Hospital Univesitario Bettina Ferro
de Souza, Belem, Brazil
5133 — B0091 Patients with severe
impairment in one eye show improved
performance to defocus-induced blur. Trisevgeni
Giannakopoulou1, S. Plainis1, 2, J. Moschandreas3,
I. G. Pallikaris1, M. K. Tsilimbaris1. 1Institute of
Vision and Optics (IVO), University of Crete,
Heraklion, Crete, Greece; 2Faculty of Life Sciences,
The University of Manchester, Manchester, United
Kingdom; 3Department of Social Medicine,
University of Crete, Heraklion, Crete, Greece
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
328
Wednesday – Posters – 5134 – 5157
Exhibit Hall B0138-B0169
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Retinal Cell Biology
471 Retinal Development II: Retina
and Vasculature
Moderator: Xiuqian Mu
5134 — B0138 Analysis of Cell Death Pathways
in Developing Retina. Shuai Li1, P. G. Fuerst1, 2.
1
Neuroscience, University of Idaho, Moscow, ID;
2
WWAMI Medical Education Program, University
of Idaho, Moscow, ID
5135 — B0139 Axin2 Disruption Causes Ocular
Defects During Mouse Eye Development. Sabine
Fuhrmann, M. Gibbons, A. Alldredge. Ophthal &
Vis Sci, University of Utah, Salt Lake City, UT
5136 — B0140 Mechanisms of retinal bipolar
cell genesis in Blimp1 (Prdm1) mutant mice.
Joseph A. Brzezinski1, K. Park1, T. A. Reh2.
1
Ophthalmology, University of Colorado Denver,
Aurora, CO; 2Biological Structure, University of
Washington, Seattle, WA
5137 — B0141 Disruption of ocular
development and function in Prickle 1 (Pk1)
mutant mouse. Chunqiao Liu1, H. Qian2, A.
Swaroop1, T. Li1. 1Neurobiology Neurodegeneration
& Repair Laboratory (N-NRL), National Eye
Institute, Bethesda, MD; 2Visual Function Core,
National Eye Institute, Bethesda, MD
5138 — B0142 Role of HDACS in the
development and maintenance of the retinal
ganglion cell layer in chick retina. Ankita Saha, T.
L. Belecky-Adams. Department of Biology Center
for Regenerative Biology and Medicine, Indiana
University Purdue University at Indianapolis,
Indianapolis, IN
5139 — B0143 Pattern of Protein
Phosphorylation in Wild Type and Rd1 Mouse
Retina. Ju Zhang, J. M. Ogilvie. Saint Louis
University, Saint Louis, MO
5141 — B0145 The Matricellular Protein
CCN1 is Required for Growth, Maturation and
Stabilization of the Retinal Vasculature. Chintala
Hemabindu1, J. Choi1, J. Shan1, M. B. Grant2,
B. Chaqour1. 1Cell Biology and Ophthalmology,
SUNY Downstate Medical Center, Brooklyn, NY;
2
Pharmacology and Therapeutics, University of
Florida, Gainesville, FL
5142 — B0146 Blood Vessel Pattern in
Subjects with Albinism. Miriam Ehrenberg1, R.
M. Hansen1, 2, A. Moskowitz1, 2, A. B. Fulton1, 2.
1
Department of Ophthalmology, Boston Children’s
Hospital, Boston, MA; 2Harvard Medical School,
Boston, MA
5144 — B0148 Development of the Rodent
Inner Blood-Retinal-Barrier. Ewa C. Kubala1, R.
J. Mrsny3, L. Paneghetti1, D. T. Shima1, 2. 1Institute
of Ophthalmology, University College London,
London, United Kingdom; 2National Institute for
Health Research Biomedical Research Centre,
Moorfields Eye Hospital NHS Foundation Trust
and UCL Institute of Ophthalmology, London,
United Kingdom; 3Department of Pharmacy and
Pharmacology, University of Bath, Bath, United
Kingdom *CR
5145 — B0149 Role of the Early Ocular
Vasculature in Regulation of Retinal
Neurogenesis. Susov Dhakal1, C. B. Stevens1, O.
Weiss2, A. Inbal2, D. L. Stenkamp1. 1Department of
Biological Sciences, University of Idaho, Moscow,
ID; 2Department of Medical Neurobiology, The
Hebrew University of Jerusalem, Jerusalem, Israel
5146 — B0150 A simple method for the
isolation, purification and cultivation of retinal
microvascular pericytes from rat. Xiaoling Liu1, 2,
G. Liu1, 3, C. Meng4, M. Pan3, Y. Zheng3, L. Lin4, L.
Zhao5. 1School of Optometry and Ophthalmology
and Eye Hospital, Wenzhou Medical College,
Wenzhou, China; 2State Key Laboratory
Cultivation Base and Key Laboratory of Vision
Science,Ministry of Health P.R. China, Wenzhou,
China; 3Department of Ophthalmology, Affiliated
People’s Hospital, Fujian University of Traditional
Chinese Medicine, Fuzhou, China; 4Department of
Bioengineering, College of Biological Science and
Biotechnology, Fuzhou University, Fuzhou, China;
5
Department of Cardiology, Affiliated People’s
Hospital, Fujian University of Traditional Chinese
Medicine, Fuzhou, China
5147 — B0151 Expression of the Axonal
Guidance Receptors EPHA5 and EPHA6
Changes Across Retinal Development. Krista M.
Beach1, H. M. Queener1, T. Kiyama2, S. W. Wang2,
D. C. Otteson1. 1Optometry, University of Houston,
Houston, TX; 2Ophthalmology & Visual Science,
Unviersity of Texas Medical School, Houston, TX
5148 — B0152 Genetic Control of Rod Bipolar
Cell Number and the Homotypic Regulation of
Dendritic Field Size. Benjamin E. Reese, P. W.
Keeley, I. E. Whitney, S. Borhanian. Neuroscience
Research Institute, Univ of California-Santa
Barbara, Santa Barbara, CA
5149 — B0153 Retinal degenerative defects
in the good effort mutant zebrafish are due to
aberrant splicing of the chaf1b RNA. Travis J.
Bailey, D. R. Hyde. Dept of Biological Sciences,
University of Notre Dame, Notre Dame, IN
5150 — B0154 TGF-β signaling protects
retinal neurons from programmed cell death
during development of the mammalian eye.
Barbara M. Braunger1, S. M. Pielmeier1, C.
Demmer1, V. I. Landstorfer1, D. Kawall1, I. Kleiter3,
D. Fischer4, H. Jägle2, E. R. Tamm1. 1Institute of
Human Anatomy and Embryology, University of
Regensburg, Regensburg, Germany; 2Department
of Ophthalmology, University Clinic, Regensburg,
Germany; 3St. Josef-Hospital, Ruhr-University
Bochum, Bochum, Germany; 4Experimental
Neurology, Heinrich-Heine-University Düsseldorf,
Düsseldorf, Germany
5151 — B0155 The role of ADAM10 in retinal
development. Joseph Toonen, D. J. Sidjanin. Cell
Biology, Neurobiology, and Anatomy, The Medical
College of Wiscosin, Milwaukee, WI
5152 — B0156 ADAM10 mediates cleavage
of N-cadherin ectodomain during retinal
ganglion cell differentiation in primary cultured
developing chick retinal cells. Jae-Chang
Jung1, S. Paudel1, Y. Kim1, 2, S. Jung1, S. Kang1,
S. Lee1, Y. Park2, K. Lee2. 1Biology, Kyungpook
national university, Daegu, Republic of Korea;
2
Ophthalmology, Cheil Eye Hospital, Daegu,
Republic of Korea
5153 — B0157 Strain dependent expression
of the alternative splicing factor, Sfrs10
and its requirement in rod outer segment
morphogenesis. Devi Krishna Priya Karunakaran,
R. N. Kanadia. Physiology and Neurobiology,
University of Connecticut, Storrs, CT
5154 — B0158 Myocilin modulates
programmed cell death during retinal
development. Marcus A. Koch1, B. Rosenhammer1,
S. E. Koschade1, B. M. Braunger1, C. Volz2, H.
Jägle2, E. R. Tamm1. 1Institute of Human Anatomy
and Embryology, University of Regensburg,
Regensburg, Germany; 2University Clinical
Center, Clinic and Policlinic for Ophthalmology,
Regensburg, Germany
5155 — B0159 Redundant Roles for Oc1 and
Oc2 in Mouse Retinal Development. Darshan
Sapkota1, 2, F. Wu1, 2, X. Mu1, 2. 1Opthalmology
and Biochemistry, University at Buffalo, Buffalo,
NY; 2SUNY Eye Institute, University at Buffalo,
Buffalo, NY
5156 — B0160 Cc2d2a is required for cilia
axoneme development. Shobi Veleri1, S. H.
Manjunath1, R. Sood4, P. Liu4, R. Fariss3, T. Li1,
R. A. Rachel1, L. Dong2, A. Swaroop1. 1NeurobiolNeurodegen & Repair Lab, NEI/NIH, Bethesda,
MD; 2Genetic Engineering Core, NEI/NIH,
Bethesda, MD; 3Biological Imaging Core, NEI/NIH,
Bethesda, MD; 4Genetics and Molecular Biology,
NHGRI/NIH, Bethesda, MD
5157 — B0161 Nuclear dynamics in retinal
development and homeostasis. Didier M.
Hodzic, D. Razafsky. Ophthalmology, Washington
University School of Medicine, St Louis, MO
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
329
Wednesday Posters
2:45 pm – 4:30 pm
5140 — B0144 Calcium binding proteins
neuroplasticity in vertebrate retinas exposed to
dim light. Nicolas S. Fosser, A. R. Paganelli, H.
Rios. Instituto de Biologia Celular y Neurociencias,
Facultad de Medicina, Universidad de Buenos
Aires, Buenos Aires, Argentina
5143 — B0147 The expression of nestin during
the vascular development in mouse retina. Yong
Woo Kim1, 2, D. Jo2, H. Jun2, J. Kim2, J. Kim1, 2.
1
Department of Ophthalmology, Seoul National
University College of Medicine, Seoul National
University Hospital, Seoul, Republic of Korea;
2
Fight against Angiogenesis-Related Blindness
(FARB) Laboratory, Clinical Research Institute,
Seoul National University Hospital, Seoul, Republic
of Korea
5158 – 5182 – Wednesday – Posters
5158 — B0162 Molecular identity and
specification of crossed versus uncrossed
retinal ganglion cells. Qing Wang1, T. Kuwajima2,
I. Cerullo2, C. A. Mason1, 2. 1Neuroscience,
Ophthalmology, Columbia University, New
York, NY; 2Pathology & Cell Biology, Columbia
University, New York, NY
5159 — B0163 Aberrant axon development
and up-regulation of c-Jun is associated with
eye opening in Down’s syndrome cell adhesion
molecule mutant. Dee Schramm1, P. G. Fuerst1, 2.
1
University of Idaho, Moscow, ID; 2WWAMI
Medical Education program, Univeristy of Idaho,
Moscow, ID
5160 — B0164 Angiotensin II selectively
activates retinal microglia in mice. Joanna A.
Phipps, N. Nag, K. A. Vessey, A. I. Jobling, E.
L. Fletcher. Anatomy and Neuroscience, The
Univeristy of Melbourne, Parkville, VIC, Australia
*CR
5161 — B0165 Expression of α-Internexin in
Developing Chicken Retina. Chi-Hsiu Liu, F. Wei,
C. Chien. Anatomy and Cell Biology, Department
of Anatomy and Cell Biology, College of Medicine,
National Taiwan University, Taipei, Taiwan
5162 — B0166 Primary Culture and
Characterization of Mouse Laminar Cells. Yan
Guo1, Z. Mehrabyan1, C. J. Charniga2, S. Temple2,
S. L. Bernstein1. 1Ophthalmology, University of
Maryland Baltimore, Baltimore, MD; 2New York
Stem Cell Institute, Albany, NY *CR
5163 — B0167 Nerve growth factor-mediated
vascular endothelial growth factor expression of
astrocyte in retinal vascular development. Jeong
Hun Kim1, Y. Kim1, H. Lee2, S. Kim2, N. Jeon2, J.
Kim1. 1Ophthalmology-Coll of Med, Seoul National
Univ Hospital, Seoul, Republic of Korea; 2School
of Mechanical and Aerospace Engineering, Seoul
National University, Seoul, Republic of Korea
Wednesday Posters
2:45 pm – 4:30 pm
5164 — B0168 Perturbations of the developing
albino mouse RPE during retinal ganglion cell
genesis. Lena Iwai, A. Ramos, R. Blazeski, C. A.
Mason. Pathology and Cell Biology, Columbia
University, New York, NY
5165 — B0169 Foxk1 is expressed in the
neuroretinal cells during development. Saadettin
Sel1, C. Muenzenberg3, N. Nass2, M. Kaiser3,
T. Kalinski2, F. E. Kruse1, F. P. Paulsen4, M.
Schicht4. 1Ophthalmology, University ErlangenNuremberg, Erlangen, Germany; 2University
Magdeburg, Magdeburg, Germany; 3University
Halle/Wittenberg, Halle/Saale, Germany; 4Anatomy
II, University Erlangen-Nuremberg, Erlangen,
Germany
Exhibit Hall B0321-B0340
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Anatomy/Pathology
472 Myopia II, AP
Moderator: William K. Stell
5166 — B0321 Megalin and myopia. Tina
Storm1, S. Heegaard2, 3, E. I. Christensen1, R.
Nielsen1. 1Department of Biomedicine, Aarhus
University, Aarhus, Denmark; 2Eye Pathology
Institute, Department of Neuroscience and
Pharmacology, University of Copenhagen,
Copenhagen, Denmark; 3Department of
Opthalmology, Glostrup Hospital, University of
Copenhagen, Copenhagen, Denmark
5167 — B0322 Refractive Development and
Form-Deprivation in Dopamine D4 Receptor
Knock-Out Mice. Han na Park1, C. C. Tan1, J. G.
Light1, F. Aseem1, P. M. Iuvone1, 2, M. T. Pardue1, 3.
1
Ophthalmology, Emory University, Atlanta, GA;
2
Pharmacology, Emory University, Atlanta, GA;
3
Rehabilitation Research & Development Center,
Atlanta Veterans Affairs Medical Center, Decatur,
GA
5168 — B0323 The effect of 2% homatropine
on the choroidal thickness of young healthy
adults. Beata P. Sander, M. J. Collins, S. A. Read.
School of Optometry and Vision Science, QUT,
Kelvin Grove, QLD, Australia
5169 — B0324 In Vivo Crosslinking of Scleral
Collagen in the Rabbit Using Sub-Tenon
Injection of Nitroalcohol. Quan V. Hoang1, 2, Q.
Wen1, S. Chang1, S. L. Trokel1, R. H. Silverman1, D.
C. Paik1. 1Ophthalmology, Harkness Eye Institute,
Columbia Univ, New York, NY; 2Vitreous, Retina,
Macula Consultants of New York, New York, NY
*CR
5170 — B0325 Cross-linking of rabbit sclera
using riboflavin and UVA for the prevention of
progressive myopia. Assaf Dotan1, I. Kremer1, A.
Zigler2, D. Bourla1. 1Ophthalmology, Rabin Medical
Center, Petach Tikva, Israel; 2Racah Institute of
Physics, The Hebrew University, Jerusalem, Israel
5171 — B0326 Vascular endothelial growth
Factor A, C, D and Vascular Endothelial Growth
Factor Receptor 1, 2, 3 mRNA Expression in
the Chicken Retina, RPE and Choroid. Marita
P. Feldkaemper, F. Schaeffel, L. Fuchs. Centre for
Ophthalmology, Institute for Ophthalmic Research,
Tuebingen, Germany
5172 — B0327 Effects of dual-focus, multizone
lenses on refractive development in macaques.
Baskar Arumugam1, 2, L. Hung1, 2, J. Huang1, 2, E.
L. Smith1, 2. 1College of Optometry, University of
Houston, Houston, TX; 2Vision CRC, Sydney,
NSW, Australia *CR
5174 — B0329 Effect of bright light on
choroidal thickness in chickens as measured
with OCT. Weizhong Lan1, 2, M. P. Feldkaemper1,
F. Schaeffel1. 1Section of Neurobiology of the
Eye, Ophthalmic Research Institute, University
of Tuebingen, Tuebingen, Germany; 2Zhongshan
Ophthalmic Center, Sun Yat-sen University,
Guangzhou, China
5175 — B0330 The efficacy of brief periods of
“vision” in chick eyes wearing negative lenses is
dependent on time of day. Debora L. Nickla, K.
Totonelly. Biosciences, New England College of
Optometry, Boston, MA
5176 — B0331 The effect of two-zone
concentric bifocal lenses on refractive error
and eye shape in guinea pigs. Hannah E.
Bowrey1, G. Zeng1, A. J. Leotta1, C. F. Wildsoet2,
S. A. McFadden1. 1The University of Newcastle,
Callaghan, NSW, Australia; 2The University of
California, Berkeley, Berkeley, CA
5177 — B0332 Comparing Rates of
Emmetropization and Diurnal Rhythms Before
and After Goggle Removal in Chick. Melanie
C. Campbell1, 2, K. Bunghardt1, M. L. Kisilak1, 2,
E. L. Irving2. 1Physics & Astronomy, University
of Waterloo, Waterloo, ON, Canada; 2School of
Optometry and Vision Science, University of
Waterloo, Waterloo, ON, Canada *CR
5178 — B0333 Temporal Frequency Sensitivity
of the Emmetropization Mechanism in Chicks
to Color and Luminance Flicker without Blue
Light. Stephanie Britton, M. Fellows, F. J. Rucker.
Biomedical Science, New England College of
Optometry, Boston, MA
5179 — B0334 The effect of induced
myopia on the scleral creep response of whole
chick eyes. Jacob A. Lewis1, M. Garcia2, C. F.
Wildsoet2. 1Bioengineering & Materials Science
and Engineering, UC Berkeley, Berkeley, CA;
2
Vision Science, University of California Berkeley,
Berkeley, CA
5180 — B0335 Inhibition in peripheral scleral
lengthening during the development of myopia
in the guinea pig. Guang Zeng, S. A. McFadden.
School of Psychology, the University of Newcastle,
Callaghan, NSW, Australia
5181 — B0336 Luminance variations can
reduce or reverse plus lens compensation in
chicks. Alan G. Busby. Biology, City College of
New York, New York, NY
5182 — B0337 Effects of a human antiVEGF antibody (Bevacizumab) on myopia
development and choroidal thickness in the
chicken. Frank Schaeffel1, U. Mathis1, F. Ziemssen.
1
Section Neurobiology of Eye, Ophthalmic
Research Institute, Tuebingen, Germany; 2Center
of Ophthalmology, University of Tuebingen,
Tuebingen, Germany *CR
5173 — B0328 Histo-pathological and
functional degenerative changes of Bruch’s
membrane in form-deprivation myopia in chicks.
Tzyy-Chang Ho. Ophthalmology, National Taiwan
Univ Hospital, Taipei, Taiwan
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
330
Wednesday – Posters – 5183 – 5204
5183 — B0338 Anti-Diuretic Hormone
Arginine-Vasopressin Promotes an Increased
Myopic Shift in Refractive Compensation to
Optical Defocus in Physiologically Stressful
Environmental Light Conditions. Melanie
J. Murphy1, S. G. Crewther1, S. N. Kiely1, N.
Riddell1, L. Giummarra1, D. P. Crewther2. 1School
of Psychological Science, La Trobe University,
Melbourne, VIC, Australia; 2Centre for Human
Psychopharmacology, Swinburne University of
Technology, Melbourne, VIC, Australia
5190 — C0005 A Phase I/II Dose-Ranging,
Randomized Clinical Trial of Abatacept
(Orencia) in the Treatment of Refractory
Non-Infectious Uveitis: Preliminary Results.
Eric B. Suhler1, 2, T. R. Giles2, S. A. Hanel2, T. L.
Liesegang2, R. M. Beardsley2, K. L. Larkin2, P. Lin2,
J. T. Rosenbaum2, 3. 1Ophthalmology, Portland VA
Medical Center, Portland, OR; 2Ophthalmology,
Casey Eye Institute-OHSU, Portland, OR;
3
Ophthalmology, Devers Eye Institute, Portland, OR
*CR, f
5196 — C0011 Risk Factors Associated with
Intraocular Pressure Rise in Patients with
Uveitis Treated with the Fluocinolone Acetonide
Implant. Anjali Parekh1, S. K. Srivastava2,
T. A. Albini3, Q. Nguyen4, D. A. Goldstein1.
1
Ophthalmology, Northwestern Medical Faculty
Foundation, Chicago, IL; 2Ophthalmology, Cole
Eye Institute, Cleveland, OH; 3Ophthalmology,
Bascom Palmer Eye Institute, Miami, FL;
4
Ophthalmology, Wilmer Eye Institute, Baltimore,
MD *CR, f
5184 — B0339 The expression of vaoactive
intestinal peptide receptors and ZENK protein
in form-deprivation myopia. Hikmet Basmak1,
H. Gursoy1, A. Cakmak1, N. Yildirim1, N. Tuncel2,
N. Erkasap2, M. Ozkurt2. 1Dept of Ophthalmology,
Eskisehir Osmangazi Univ Med Sch, Eskisehir,
Turkey; 2Physiology, Eskisehir Osmangazi Univ
Med Sch, Eskisehir, Turkey *CR
5191 — C0006 Effectiveness of anti-Tumor
Necrosis Factor agents in Pediatric Population
with Uveitis. Rula Hajj-ali1, M. M. Choudhary2,
A. Zeft4, S. Spalding4, S. K. Srivastava3, C. Y.
Lowder3. 1Orthopedics and Rheumatologic Institute,
Cleveland Clinic Foundation, Cleveland, OH;
2
Internal Medicine, Cleveland Clinic Foundation,
Cleveland, OH; 3Ophthalmology, Cleveland
Clinic Foundation, Cleveland, OH; 4Pediatric
Rheumatology, Cleveland Clinic Foundation,
Cleveland, OH *CR
5197 — C0012 Fluocinolone Acetonide
Implants for Refractory Uveitis: a Retrospective
Review. Harpal S. Sandhu, P. Pillai, G. N.
Papaliodis. Ophthalmology, Massachusetts Eye and
Ear Infirmary, Boston, MA
5185 — B0340 Effects of Adenosine A2A
Receptor on the Development of FormDeprivation Myopia in Mice. Jianhong An1,
X. Zhou1, F. Shi1, J. Chen1, 2, J. Qu1. 1School of
Ophthalmology & Optometry, Wenzhou Medical
College, Wenzhou, Zhejiang, China; 2Department of
Neurology, Boston University School of Medicine,
Boston, MA
Exhibit Hall C0001-C0021
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Immunology/Microbiology
473 Non-infectious Inflammation
Moderator: Kazuichi Maruyama
5186 — C0001 Etiology of Non-infectious
Uveitis Following Cataract Surgery. Zvi A.
Kresch1, C. Yang3, V. Diaz1, S. Kedhar1, J. V.
Mauro2, C. Samson1. 1Ophthalmology, NY Eye and
Ear, New York, NY; 2North Shore Eye Care, New
York, NY; 3High School, Newark, NJ *CR
5188 — C0003 Epidemiology of Infectious
Uveitis in Alabama. Christopher J. Compton,
C. Huisingh, G. McGwin, R. W. Read, K. Beck.
Ophthalmology, Univ of AL - Birmingham,
Birmimgham, AL
5189 — C0004 Characteristics of HLA-B27/
Ankylosing Spondylitis Associated Uveitis in
Different Ethnicities. Russell W. Read1, 2, K.
Beck1. 1Ophthalmology, University of Alabama
at Birmingham, Birmingham, AL; 2Pathology,
University of Alabama at Birmingham,
Birmingham, AL
5193 — C0008 Pharmacological blockade
of interleukin 6 receptor (IL-6R) inhibits the
development of ocular inflammation in the
murine model of experimental autoimmune
uveitis (EAU). Jingtai Cao, T. C. MacPherson, G.
D. Yancopoulos, S. J. Wiegand. Ophthalmology,
Regeneron Pharmaceuticals Inc, Tarrytown, NY
*CR
5194 — C0009 Treatment of Chronic,
Persistent, Non-infectious, Non-granulomatous
Uveitis in Patients with Juvenile Idiopathic
Arthritis. Anton M. Kolomeyer1, Y. Tu1, N. V.
Nayak1, E. Miserocchi2, D. S. Chu1, 3. 1Institute of
Ophthalmology and Visual Science, University
of Medicine and Dentistry of NJ, Newark, NJ;
2
Department of Ophthalmology and Visual
Sciences, Scientific Institute San Raffaele,
University Vita-Salute, Milan, Italy; 3Metropolitan
Eye Research and Surgery Institute, Palisades Park,
NJ *CR
5195 — C0010 Characteristics of patients who
attain remission of inflammatory eye disease
following treatment and discontinuation of
mycophenolate mofetil. Travis Jenkins, T. Truong,
K. Lai, Z. A. Kresch, V. Diaz, J. V. Mauro, S.
Kedhar, C. Samson. Ophthalmology, The New York
Eye and Ear Infirmary, New York, NY *CR
5199 — C0014 Macular thickness
measurements with spectral domain optical
coherence tomography during active episode of
Unilateral Acute Anterior Uveitis. David DiazValle, S. Garcia-Vidal, P. Arriola-Villalobos, R.
Cuina, J. A. Gegundez-Fernandez, J. M. Benitezdel-Castillo. Ophthalmology, Hospital Clinico San
Carlos, Madrid, Spain
5200 — C0015 Evolution of intra ocular
inflammation in treated acute anterior uveitis.
Margaux Guillard1, E. Perrin2, B. Kirwan2, D.
Monnet1, A. P. Brezin1. 1Ophthalmology, Cochin
Hospital - University Paris Descartes, Paris, France;
2
Socar Research SA, Nyon, Switzerland
5201 — C0016 Use of Immunosuppressive
Medications for Treatment of Pediatric
Intermediate Uveitis. Spencer R. Cope1, A. O.
Hersh1, A. Shakoor2, J. F. Bohnsack1, A. T. Vitale2.
1
Division of Pediatrics Rheumatology, University
of Utah, Salt Lake City, UT; 2Ophthalmology and
Visual Sciences, John A. Moran Eye Center, Salt
Lake City, UT *CR
5202 — C0017 Genetic analysis of risk alleles
associated with inflammatory bowel disease
in acute anterior uveitis. Tammy M. Martin, P.
Stauffer, E. Patridge, C. Younkins, M. Burcham, J.
R. Smith. Ophthalmology, Oregon Health & Science
Univ, Portland, OR
5203 — C0018 Optic nerve spectral domain
optical coherence tomography of papillitis
secondary to uveitis. Parvathy Pillai, L. Sobrin.
Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA
5204 — C0019 Correlation between Disease
Activity and Choroidal Patterns by OCT-EDI in
Birdshot Chorioretinopathy. Andrea D. Birnbaum,
A. A. Fawzi, L. M. Rifkin, D. A. Goldstein.
Ophthalmology, Northwestern Univ Feinberg Sch
of Med, Chicago, IL *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
331
Wednesday Posters
2:45 pm – 4:30 pm
5187 — C0002 Trends in Patterns of
Intermediate Uveitis in a Tertiary Institution in
Singapore. Helen Mi1, S. Ho2, W. Lim2, E. Wong2,
S. C. Teoh2. 1Yong Loo Lin School of Medicine,
National University of Singapore, Singapore,
Singapore; 2Ophthalmology, National Healthcare
Group Eye Institute, Tan Tock Seng Hospital,
Singapore, Singapore
5192 — C0007 Multicenter study of TNF-a
antagonists for refractory Behçet’s uveitis in
Spain. Marina Mesquida1, D. Diaz-Valle2, M.
Cordero Coma3, A. Fonollosa4, V. Llorens1, L.
Pelegrin1, M. Hernandez5, G. Espinosa6, B. Molins1,
A. Adan Civera1. 1Ophthalmology, Hospital Clinic
de Barcelona, Barcelona, Spain; 2Ophthalmology,
Hospital Clinico San Carlos, Madrid, Spain;
3
Ophthalmology, Hospital de León, León, Spain;
4
Ophthalmology, Hospital Universitario Cruces,
Bilbao, Spain; 5Rheumatology, Hospital Clínic
de Barcelona, Barcelona, Spain; 6Autoimmune
Disease, Hospital Clínic de Barcelona, Barcelona,
Spain *CR
5198 — C0013 Combination chemotherapy
with Mycophenolate mofetil and Cyclosporin
in recalcitrant uveitis. Reena A. Rasheed1, 2, G.
T. Markov1, 3, C. Foster1. 1Ocular Immunology,
Massachussett’s Eye Research and Surgery
Institution, Massachussetts, MA; 2Regional Institute
of Ophthalmology, Trivandrum, India; 3University
Eye Hospital, Pashev, Bulgaria *CR
5205– 5228 – Wednesday – Posters
5205 — C0020 Segmentation and Analysis
of Retinal Layers in Eyes with Uveitis and
Comparison with Normal. Syed Mahmood A.
Shah, Y. J. Sepah, M. A. Sadiq, S. Kherani, M.
A. Ibrahim, Z. S. Rentiya, M. Ansari, D. V. Do,
Q. Nguyen. Wilmer Eye Institute, Johns Hopkins
University, Baltimore, MD *CR
5206 — C0021 Predictive Value of Angiotensin
Converting Enzyme, Soluble Interleukin-2
Receptor and Lysozyme for Pulmonary
Involvement in Human Ocular Sarcoidosis.
Rafael Grajewski1, W. Adler2, K. Frank3, M.
Arfaoui1, S. L. Schlereth1, B. Kirchhof1, C.
Cursiefen1, L. M. Heindl1. 1Ophthalmology,
University of Cologne, Cologne, Germany;
2
Medical Informatics, Biometry and Epidemiology,
Friedrich-Alexander University Erlangen-Nürnberg,
Erlangen, Germany; 3Internal Medicine III,
University of Cologne, Cologne, Germany *CR
Exhibit Hall C0126-C0141
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Immunology/Microbiology
474 Corneal Infection/Inflammation I
Moderator: Robert M. Shanks
5207 — C0126 MyD88-dependent and
-independent antimicrobial activity in mouse
corneas induced by Pseudomonas aeruginosa
antigen challenge. Suzanne M. Fleiszig, D. J.
Evans, C. Tam. School of Optometry, Univ of
California - Berkeley, Berkeley, CA *CR
Wednesday Posters
2:45 pm – 4:30 pm
5208 — C0127 An Experimental Model
of Biofilm Formation in the Mouse Cornea.
Padmanabhan Saraswathi, T. T. Aung, S. Salleh, R.
W. Beuerman. Singapore Eye Research Institute,
Singapore, Singapore *CR
5209 — C0128 The role of autophagy in
Pseudomonas aeruginosa keratitis. Xiaoyu Jiang,
S. A. McClellan, R. P. Barrett, Y. Zhang, M. E.
Foldenauer, K. Vistisen, L. D. Hazlett. Department
of Anatomy and Cell Biology, Wayne State
University School of Medicine, Detroit, MI
5210 — C0129 Toll-like receptor 4: A regulator
of apoptosis in the infected cornea. Sharon A.
McClellan, X. Jiang, Y. Zhang, K. Vistisen, R. P.
Barrett, L. D. Hazlett. Anatomy & Cell Biology,
Wayne State Univ School of Med, Detroit, MI
5211 — C0130 Galectin-1-Mediated
Suppression of Th17 Cell-Induced Corneal
Immunopathology post Pseudomonas aeruginosa
Infection. Amol Suryawanshi1, Z. Cao1, T. S. Zaidi2,
N. A. Panjwani1. 1New England Eye Center and
Department of Ophthalmology, Tufts University
School of Medicine, Boston, MA; 2Department of
Medicine, Brigham and Women’s Hospital, Boston,
MA
5212 — C0131 In Vivo Efficacy of KeratinDerived Antimicrobial Peptides (KDAMPs)
in Corneal Defense Against Pseudomonas
aeruginosa. Connie Tam. School of Optometry,
Univ of California, Berkeley, Berkeley, CA *CR
5213 — C0132 Proteomic Analysis of the
Keratitis Associated Pseudomonas aeruginosa.
Abby L. Sewell, J. J. Dunmire, M. Wehmann, R.
Bouhenni. Ophthalmology Research, Summa Health
System, Akron, OH
5214 — C0133 Pseudomonas aeruginosa uses
type three secretion-dependent and -independent
mechanisms for traversal of multilayered corneal
epithelia. Aaron B. Sullivan1, V. Hritonenko1, C.
Tam1, D. J. Evans2, S. M. Fleiszig1. 1School of
Optometry, UC Berkeley, Berkeley, CA; 2College
of Pharmacy, Turo University- California, Vellejo,
CA *CR
5215 — C0134 ExoS, a type III secreted toxin,
is produced intracellularly by P. aeruginosa after
corneal epithelial cell invasion, and is triggered
by exposure to cell lysates. Victoria Hritonenko1,
A. L. Jolly1, C. Maloney2, A. Farfel3, D. J. Evans1, 4,
S. M. Fleiszig1. 1School of Optometry, University of
California, Berkeley, CA; 2Dept. of Environmental
Science, Policy, and Management, University of
California, Berkeley, AR; 3Dept. of Molecular &
Cell Biology, University of California, Berkeley,
CA; 4College of Pharmacy, Touro University
California, Vallejo, CA *CR
5216 — C0135 VIP Treatment of Bacterial
Keratitis Against Multiple Pseudomonas Strains.
Elizabeth A. Berger, L. D. Hazlett. Anatomy & Cell
Biology, Wayne State Univ Sch of Med, Detroit, MI
5217 — C0136 IL-1R and TLR-5 mediate
corneal epithelial defense against Pseudomonas
aeruginosa colonization and traversal
respectively. David J. Evans1, 2, C. Tam2, S. M.
Fleiszig2. 1College of Pharmacy, Touro University
California, Vallejo, CA; 2School of Optometry, UC
Berkeley, Berkeley, CA *CR
5218 — C0137 Microbiological and electron
microscopic assessment of Pseudomonas
aeruginosa infection of primary human corneal
fibroblasts and epithelial cells in-vitro. Ahmad
Elsahn1, 2, P. Hossain2, 1, M. Christodoulides1.
1
Molecular Microbiology, University of
Southampton, Southampton, United Kingdom;
2
Southampton Eye Unit, University Hospitals
Southampton NHS Foundation Trust, Southampton,
United Kingdom
5219 — C0138 Cystic Fibrosis Transmembrane
conductance Regulator (CFTR) competes with
Pseudomonas aeruginosa Type 3 Secretion
System (T3SS) to direct the fate of intracellular
bacteria. Amber L. Jolly1, S. A. Whiteside1, D. J.
Evans2, 1, S. M. Fleiszig1. 1Vision Sciences, UC
Berkeley, Berkeley, CA; 2College of Pharmacy,
Touro University, Vallejo, CA *CR
5220 — C0139 Impediment of corneal cell
migration by a Serratia marcescens factor in an
in vitro wound healing model. Kimberly Brothers,
N. A. Stella, J. Klarlund, R. M. Shanks. University
of Pittsburgh, Pittsburgh, PA *CR
5221 — C0140 Isolation of Two Proteases
from Streptococcus pneumoniae that Cause
Corneal Erosions. Mary E. Marquart, S. D.
Taylor. Microbiology, Univ of Mississippi Med Ctr,
Jackson, MS
5222 — C0141 Genomics of the Conjunctival
Pathogen Streptococcus pneumoniae. Michael
Valentino1, W. Haas2, C. M. Sanfilippo2, J. W.
Rosch3, E. I. Tuomanen3, T. W. Morris2, M. S.
Gilmore1. 1Harvard Medical School / Mass. Eye
& Ear Infirmary, Boston, MA; 2Bausch & Lomb,
Inc., Rochester, NY; 3St. Jude Children’s Research
Hospital, Memphis, TN *CR
Exhibit Hall C0142-C0156
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Cornea / Biochemistry/Molecular Biology
475 Corneal Wound Repair,
Transparency II
Moderator: Shizuya Saika
5223 — C0142 MicroRNA signature in wound
healing following excimer laser ablation:
Role of miR-133b on TGF- β, CTGF, collagen
and smooth muscle actin synthesis in corneal
fibroblast. Paulette M. Robinson1, 2, T. Chuang1, S.
Sriram1, L. Pi1, X. Luo1, B. Petersen2, G. S. Schultz1.
1
OB-GYN, University of Florida, Gainesville, FL;
2
Pediatrics, University of Florida, Gainesville, FL
5224 — C0143 Long-term visual outcomes
in the Steroids for Corneal Ulcers Trial. Scott
M. McClintic1, S. M. McClintic1, N. V. Prajna2,
M. Srinivasan2, J. Mascarenhas2, L. Prajna2,
T. Porco1, 3, N. Acharya1, 3, T. M. Lietman1, 3, J.
D. Keenan1, 3. 1Ophthalmology, University of
California, San Francisco, San Francisco, CA;
2
Cornea and External Diseases, Aravind Eye Care
System, Madurai, India, Madurai, India; 3Francis I.
Proctor Foundation, University of California, San
Francisco, San Francisco, CA *CR
5225 — C0144 The Effect of Local RockInhibition on Corneal Scarring After Alkali
Burn Injury. Davine Sijnave1, K. P. Hollanders1,
T. Van Bergen1, S. Van de Velde1, E. Vandewalle1,
L. K. Moons2, D. Leysen3, I. Stalmans1. 1Lab of
Ophthalmology, KULeuven, Leuven, Belgium;
2
Department of Biology, KULeuven, Leuven,
Belgium; 3Amakem Therapeutics, Diepenbeek,
Belgium *CR
5226 — C0145 Abnormal epithelial basement
membrane ultrastructure in corneas with haze
after PRK in rabbits. Andre A. Torricelli1, 2, V.
Singh1, V. Agrawal1, S. E. Wilson1. 1Ophthalmology,
Cleveland Clinic, Cleveland, OH; 2Ophthalmology,
FMUSP, Sao Paulo, Brazil *CR
5227 — C0146 Substance P potentiates
Anti-Fas induced apoptosis in human corneal
fibroblasts. Peter Boman1, 2, S. Le Roux1, P.
Danielson1, 2. 1Anatomy, Umeå University, Umeå,
Sweden; 2Dept. of Clinical Science, Ophthalmology,
Umeå Univeristy, Umeå, Sweden
5228 — C0147 TGF-β1 modulates the
functional expression of the NK-1 receptor in
human corneal fibroblasts. Sandrine LE ROUX, P.
Boman, P. Danielson. Anatomy, Dept. of Integrative
Medical Biology, Anatomy, Umeå University,
Umeå, Sweden
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
332
Wednesday – Posters – 5229 – 5251
5229 — C0148 A Long-Lasting Scar in Murine
Cornea. Andrew Hertsenberg, S. Basu, Y. Du, J.
L. Funderburgh. Ophthalmology, University of
Pittsburgh School of Medicine, Pittsburgh, PA
5230 — C0149 Autologous Platelet Rich
Plasma Therapy in Resistant Corneal Ulcers.
Yakup Aksoy1, U. Erdem2. 1Ophthalmology, Gülhane
Military Medical Academy Haydarpasa Education
Hospital, istanbul, Turkey; 2Ophthalmology,
Gülhane Military Medical Faculty, Ankara, Turkey
5231 — C0150 Initial Evidence that Immune
Cell Infiltrates are Candidate Sources of PostSurface Ablation Stromal Roughening. Daniel J.
Gibson, G. S. Schultz. Obstetrics and Gynecology,
University of Florida, Gainesville, FL
5232 — C0151 Outcomes of Traumatic
Dehiscence of Penetrating Keratoplasty versus
Severe Open-Globe Injury. Therese Peron,
M. A. Woodward, R. M. Shtein. Department of
Ophthalmology, University of Michigan, Ann
Arbor, MI
5233 — C0152 Proteomic analysis of the
interaction Fusarium solani - Staphylococcus
epidermidis isolated from human corneal
ulcers. Mariana Ortiz-Casas1, A. V. RodríguezTovar2, J. Reyes-Grajeda3, H. Mejia-Lopez1, M.
A. Martínez-Rivera2, L. A. Bautista-Hernández1,
C. Gaona-Juárez1, N. López-Espinosa1, V. M.
Bautista1. 1Microbiology and Proteomics, Institute
of Opthalmology “Conde de Valenciana”, Mexico
City, Mexico; 2Medical Mycology, Escuela
Nacional de Ciencias Biológicas, IPN, Mexico
City, Mexico; 3Medical Proteomics Unit, Instituto
Nacional de Medicina Genómica, Mexico City,
Mexico
5235 — C0154 A Role for Macrophage-derived
Interleukin-20 in Mouse Corneal Epithelial
Wound Healing. Wanyu Zhang1, C. W. Smith2,
Z. Li2, A. R. Burns1, 2. 1College of Optometry,
University of Houston, Houston, TX; 2Pediatricsleukocyte biology, Baylor College of Medicine,
Houston, TX
5236 — C0155 The Effects of Amniotic
Membrane Extract on Primary Human Corneal
Epithelial Cells. David V. Dudok1, K. Cheung1,
H. Liu1, L. Vedovelli3, E. Ghinelli2, K. Kenyon2,
S. Parapuram1, C. M. Hutnik1. 1Ophthalmology,
Western University Canada, London, ON, Canada;
2
Ophthalmology, Massachusetts Eye & Ear
Infirmary, Boston, MA; 3Division of Nephrology,
Cell Biology, Human Biology and Physiology,
Massachusetts General Hospital, Boston, MA
Exhibit Hall C0157-C0177
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Cornea
476 Corneal Stroma and Keratocytes
Moderator: Holly B. Hindman
5238 — C0157 Keratocyte-Keratocyte
Translamellar Connectivity in the Mouse Cornea
is Revealed using a Novel 3-D Ultrastructural
Approach. Samuel D. Hanlon1, N. C. Shenoi1,
P. T. Harris1, P. T. Landry1, A. R. Behzad2, E. S.
Brown1, M. M. Gondo1, A. R. Burns1, 3. 1Research,
Univ of Houston College of Optometry, Houston,
TX; 2Imaging and Characterization Core Lab, King
Abdullah University of Science and Technology,
Thuwal, Saudi Arabia; 3Leukocyte Biology, Baylor
College of Medicine, Houston, TX
5239 — C0158 Effect of Serum Clot Activator
on Keratocytes. Ji-Eun Lee1, S. Lee2, J. Lee1.
1
Ophthalmology, Pusan National University,
Pusan, Republic of Korea; 2Ophthalmology, Kosin
University, Pusan, Republic of Korea
5240 — C0159 Co-cultures of Human Corneal
Epithelium and Self-assembled Keratocyte
and Fibroblast Matrix. Audrey E. Hutcheon1, 2,
D. Karamichos1, 2, X. Q. Guo1, 2, J. D. Zieske1, 2.
1
Schepens Eye Research Institute/MEE, Boston,
MA; 2Department of Ophthalmology, Harvard
Medical School, Boston, MA
5241 — C0160 RNAi Gene Silencing Of TGFbeta Signaling: A Powerful Approach To Control
Corneal Fibrosis. Jason T. Rodier, A. Sharma,
A. Tandon, A. Stallard, R. R. Mohan. Mason
Eye Institute, University of Missouri-Columbia,
Columbia, MO
5242 — C0161 Up-Regulation of Apoptotic
Markers Following β-Actin Gene-Silencing
in Corneal Stromal Fibroblasts. Roy Joseph1,
O. P. Srivastava1, R. R. Pfister2. 1Department of
Vision Sciences, Univ of Alabama at Birmingham,
Birmingham, AL; 2Eye Research Foundation,
Birmingham, AL
5244 — C0163 Alarmin from corneal epithelial
cells synergizes with Th2 cytokines on the
expression of CCL11 and VCAM-1 by corneal
fibroblasts. Ken Fukuda1, H. Tanaka2, W. Ishida1,
Y. Harada1, T. Sumi1, A. Matsuda3, N. Ebihara3,
A. Fukushima1. 1Ophthalmology, Kochi Medical
School, Nankoku, Japan; 2Ophthalmology, Machida
Hospital, Kochi, Japan; 3Ophthalmology, Juntendo
University School of Medicine, Tokyo, Japan *CR
5245 — C0164 Mitomycin C Suppresses
Gene Splicing in Corneal Fibroblasts. Tsan-Chi
Chen1, S. Chang1, 2, C. Lee1, H. Teng1. 1Department
of Ophthalmology, Far Eastern Memorial
Hospital, New Taipei City, Taiwan; 2Department
of Ophthalmology, National Taiwan University
Hospital, Taipei, Taiwan f
5246 — C0165 The anti-fibrotic Halofuginone
regulates the expression of Egr-1 in human
corneal fibroblasts. Ching Yuan, M. Twite, E. F.
Nelson. Ophthalmology and Visual Neurosciences,
University of Minnesota, Minneapolis, MN
5247 — C0166 Effect of TGF-β1 and 3 on
protein expression in human corneal fibroblasts.
Xiaoqing Q. Guo1, 2, A. E. Hutcheon1, 2, J. D.
Zieske1, 2. 1Schepens Eye Research Institute/MEE,
Boston, MA; 2Department of Ophthalmology,
Harvard Medical School, Boston, MA
5248 — C0167 Thrombin regulates Cyr61
synthesis and processing in cultured human
corneal stromal fibroblasts and myofibroblasts.
Emily A. Andreae1, D. J. Warejcka1, S. S. Twining2.
1
Biochemistry, The Medical College of Wisconsin,
Milwaukee, WI; 2Biochemistry and Ophthalmology,
The Medical College of Wisconsin, Milwaukee, WI
5249 — C0168 Trichostatin A inihibits TGFβ-induced reactive oxygen species accumulation
and myofibroblast differentiation via enhanced
Nrf2-ARE signaling. Qingjun Zhou, L. Yang, M.
Qu. Shandong Eye Institute, Qingdao, China
5250 — C0169 Exploring cell plasticity: the
corneal keratocyte and beyond. Carol A. Greene,
T. Sherwin, C. R. Green. Ophthalmology, University
of Auckland, Auckland, New Zealand
5251 — C0170 Reprogramming Genes Are
Expressed during Spheroidal Culture of Corneal
Stromal Cells. Yong-Soo Byun, L. Yco, B. Shaheen,
A. Sharma, S. Chaudhary, S. Gandhi, S. H. Jassim,
J. Sarkar, S. Tibrewal, S. Jain. Ophthalmology and
Visual Sciences, University of Illinois at Chicago,
Chicago, IL *CR
5243 — C0162 Collective Spreading and
Migration of Corneal Fibroblasts in Fibrin
Matrices are not Dependent on Increased Cell
Contractility. Miguel Miron Mendoza, M. Petroll.
Ophthalmology, Univ of Texas Southwestern Med
Ctr, Dallas, TX
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
333
Wednesday Posters
2:45 pm – 4:30 pm
5234 — C0153 Collagen vitrigels for cornea
reconstruction: collagen source and crosslinking.
Shoumyo Majumdar1, 2, M. Garza-Madrid2, 3, X.
Calderon-Colon4, M. Trexler4, O. D. Schein5,
J. Elisseeff1, 2. 1Biomedical Engineering, Johns
Hopkins University, Baltimore, MD; 2Translational
Tissue Engineering Center, Wilmer Eye Institute,
Johns Hopkins School of Medicine, Baltimore,
MD; 3Ophthalmology and Visual Sciences
Research Chair, School of Medicine and Health
Sciences, Tecnológico de Monterrey, Monterrey,
Mexico; 4Applied Physics Laboratory, Johns
Hopkins University, Laurel, MD; 5Department
of Ophthalmology, Wilmer Eye Institute, Johns
Hopkins School of Medicine, Baltimore, MD *CR
5237 — C0156 Sex-Specific Differences in the
Corneal Inflammatory Reparative Response via
Estrogen Modulation of Phagocytosis. Samantha
B. Wang, K. M. Hu, Y. Wang, D. W. Lin, J. Jong,
J. Lai, K. Gronert. Vision Science Program,
University of California, Berkeley, Oakland, CA
5252 – 5276 – Wednesday – Posters
5252 — C0171 Tissue-engineered corneal
stromal substitutes transplanted in the living
feline model: biocompatibility, ultrastructure
and performance. Marie Boulze Pankert1, 2, B.
Goyer3, M. Bareille2, K. Singh2, S. Proulx3, 5, I.
Brunette2, 4. 1Departement d’ophtalmologie, Centre
Hospitalier Universitaire de l’Université de la
Mediterranée, Marseille, France; 2MaisonneuveRosemont Hospital Research Center, Montreal, QC,
Canada; 3Centre LOEX de l’Université Laval, Génie
tissulaire et régénération - Centre de recherche
FRQS du Centre Hospitalier Universitaire, Quebec,
QC, Canada; 4Department of Ophthalmology,
University of Montreal, Montreal, QC, Canada;
5
Département d’ophtalmologie et d’oto-rhinolaryngologie, Faculté de médecine, Université
Laval, Quebec, QC, Canada
Wednesday Posters
2:45 pm – 4:30 pm
5253 — C0172 Reinnervation of corneal
stroma reconstructed by tissue engineering
transplanted in the living feline model. Fatma
Zaguia1, M. Boulze Pankert2, 1, B. Goyer3, S.
Proulx3, 5, I. Brunette1, 4. 1Hopital Maisonneuve
Rosemont, Montreal, QC, Canada; 2Université
de la Mediterranée, Marseille, France; 3Centre
de recherche FRSQ de Centre hospitalier affilié
universitaire du quebec- Universite Laval, Quebec,
QC, Canada; 4Université de Montréal, Montreal,
QC, Canada; 5Université Laval, Montreal, QC,
Canada
Exhibit Hall C0178-C0224
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Cornea
477 Corneal Cross-linking and
Keratoconus
Moderator: Shameema Sikder
5259 — C0178 MDV1224 A New Riboflavin
Formulation for Trans-Epithelial Cross-Linking.
Sergio Mangiafico, D. Aleo. R&D, Medivis,
Catania, Italy *CR
5260 — C0179 Corneal sensitivity changes
following cross-linking for progressive lower
stage keratoconus. Belquiz A. Nassaralla1, A. M.
Lago1, L. S. Stival1, J. J. Nassaralla2. 1Cataract
Cornea & Refractive Surgery, Instituto de Olhos
de Goiania, Goiania, Brazil; 2Retina and Vitreous,
Instituto de Olhos de Goiania, Goiania, Brazil f
5261 — C0180 Impact of corneal cross-linking
on drug penetration in humans. Christoph
Tappeiner, M. Tschopp, K. Schuerch, B. E. Frueh.
Department of Ophthalmology, Inselspital,
University Hospital of Bern, Bern, Switzerland
5254 — C0173 A stromal corneal nerves
analysis in type 2 diabetic patients by confocal
microscopy. Manuel Ramirez, E. HernandezQuintela. Cornea, APEC, Mexico City, Mexico
5262 — C0181 Apparent progression in
children after corneal cross-linking for
keratoconus. Beatrice E. Frueh, C. Tappeiner.
Ophthalmology, Univ of Bern Inselspital, Bern,
Switzerland
5255 — C0174 Interclass Synergistic Effects of
Small Leucine-Rich Proteoglycans in Regulating
Collagen Fibrillogenesis During Corneal
Development. Shoujun Chen1, S. Chakravarti2, D.
E. Birk1. 1Department of Molecular Pharmacology
and Physiology, University of South Florida,
Tampa, FL; 2Department of Medicine, Johns
Hopkins University, Baltimore, MD
5263 — C0182 Corneal Endothelial Cell
Density Following Transepithelial Collagen
Cross-Linking. Michael W. Raciti1, R. J. Epstein1, 2,
P. Majmudar1, 2, W. Trattler3. 1Rush University
Medical Center, Chicago, IL; 2Chicago Cornea
Consultants, Chicago, IL; 3Center For Excellence In
Eye Care, Miami, FL *CR
5256 — C0175 Collagen XII regulates
collagen fibril packing, lamellar organization,
stromal architecture and corneal function.
Chinda Hemmavanh1, E. M. Espana1, 2, D. E.
Birk1. 1Molecular Pharmacology and Physiology,
USF Morsani College of Medicine, Tampa, FL;
2
Ophthalmology, University of South Florida,
Tampa, FL
5257 — C0176 Extracellular matrix
characterization of the acellular gammairradiated cornea. Jemin J. Chae1, J. S. Choi1,
W. Stark2, J. Elisseeff1. 1Biomedical Engineering,
Johns Hopkins University, Baltimore, MD;
2
Ophthalmology, Johns Hopkins University,
Baltimore, MD *CR
5258 — C0177 Structural changes in the
anterior corneal stroma of bullous keratopathy
patients after endothelial keratoplasty. Naoyuki
Morishige, Y. Morita, N. Yamada, K. Sonoda. Dept
of Ophthalmology, Yamaguchi Univ Grad Sch of
Med, Ube, Japan
5264 — C0183 Concurrent vs Sequential
Corneal Collagen Crosslinking and Intacs®
for Keratoconus and Corneal Ectasia. Steven
A. Greenstein1, 2, P. S. Hersh2, 1. 1Ophthalmology,
UMDNJ - New Jersey Medical School, Newark,
NJ; 2Cornea and Laser Eye Institute - Hersh Vision
Group, Teaneck, NJ *CR, f
5265 — C0184 A new constant-force technique
to measure corneal biomechanical changes after
corneal collagen cross-linking. David Tabibian1,
O. Richoz1, E. Spoerl3, A. Hammer1, F. Hoogewoud1,
F. Hafezi1, 2. 1Ophthalmology, Geneva University
Hospital, Geneva, Switzerland; 2Ophthalmology,
Doheny Eye institute, Keck School of Medicine
USC, Los Angeles, CA; 3Ophthalmology,
University Hospital Dresden, Dresden, Germany
*CR
5266 — C0185 Corneal collagen crosslinking
in young patients: One-year results. Marcony
R. Santhiago2, 1, M. L. Monteiro1, H. Moraes1,
R. Espindola1, R. C. Ghanem1, M. Netto1.
1
Ophthalmology, Federal University of Rio de
Janeiro, Rio de Janeiro, Brazil; 2Cataract and
Refractive Surgery - Ophthalmology, Federal
University of Rio de Janeiro, Rio de Janeiro, Brazil
5267 — C0186 Two-year results of corneal
cross-linking in pediatric patients with
progressive keratoconus. Dan Epstein1, B. E.
Frueh2, E. Albé3, P. Vinciguerra3. 1Ophthalmology,
Research Institute, Bern, Switzerland;
2
Ophthalmology, University of Bern, Inselspital,
Bern, Switzerland; 3Ophthalmology, Istituto clinico
Humanitas, Milan, Italy *CR
5268 — C0187 Fluorescein Competes
Riboflavin in CXL (Corneal Collagen CrossLinking) for the Treatment of Infectious
Keratitis. Farhad Hafezi1, 2, Z. Gatzioufas1,
A. Hammer1, D. Tabibian1, O. Richoz1.
1
Ophthalmology, Geneva University Hospitals,
Geneva, Switzerland; 2Ophthalmology, Doheny
Eye Institute, Keck School of Medicine USC, Los
Angeles, CA *CR
5269 — C0188 In Vivo Ultrasound-enhanced
Penetration Of Topical Riboflavin Into The
Corneal Stroma. Ricardo Lamy, E. Chan, H.
Zhang, V. Salgaonkar, C. J. Diederich, J. M.
Stewart. Ophthalmology, University of California,
San Francisco, San Francisco, CA
5270 — C0189 Combining Iontophoresis and
corneal collagen crosslinking: a basic science
study on human corneas. Rita Mencucci, I.
Paladini, E. Favuzza, U. Menchini, M. Marini, E.
Sarchielli, B. Vannelli. Ophthalmology, Eye Clinic
University of Florence, Firenze, Italy
5271 — C0190 Accelerated cross-linking in
patients with keratoconus: 6 months follow-up.
Johnny Javier Castellar Cerpa, J. Peraza Nieves, R.
Cuiña Sardiña, D. Diaz-Valle, R. Mendez, J. García
Bella, J. Fernández-Vigo, J. M. Benitez-del-Castillo.
Ophthalmology, Hospital Clinco San Carlos,
Madrid, Spain
5272 — C0191 Corneal Deformation
Characteristics and IOP before and after
Collagen Crosslinking. Cynthia J. Roberts, A.
M. Mahmoud, R. G. Lembach, T. F. Mauger.
Department of Ophthalmology and Department of
Biomedical Engineering, The Ohio State University,
Columbus, OH *CR, f
5273 — C0192 Results of cross-linking in
keratoconic corneas on visual function. One
year follow-up. Ricardo Cuina, J. VazquezMolini, D. Diaz-Valle, J. M. Benitez-del-Castillo.
Oftalmología, Hospital Clínico San Carlos, Madrid,
Spain
5274 — C0193 Impact of Riboflavin
Formulations on Corneal Hydration. Evan A.
Sherr, P. Kamaev, S. Rood-Ojalvo, M. D. Friedman,
D. Muller. Avedro, Inc, Waltham, MA *CR
5275 — C0194 Assessment the long term effect
of corneal cross-linking therapy on corneal
ectasia in progressive keratoconus. Illes Kovacs,
K. Kranitz, A. Gyenes, G. L. Sándor, E. Juhasz,
L. Dienes, J. Nemeth, Z. Z. Nagy. Department of
Ophthalmology, Semmelweis University, Budapest,
Hungary *CR
5276 — C0195 Use of Zonal Km vs Point Kmax
for Analysis of Corneal Cross-linking Pentacam
Topography. Grace Lytle1, M. D. Friedman1, P. S.
Hersh2, D. Muller1. 1Avedro Inc, Waltham, MA;
2
Hersh Vision Group, Cornea and LASER EYE
Institute, Teaneck, NJ *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
334
Wednesday – Posters – 5277 – 5302
5277 — C0196 Evaluation of corneal flattening
in progressive keratoconus with Scheimpflug
imaging. Kinga Kranitz, I. Kovacs, A. Gyenes, G.
L. Sándor, E. Juhasz, L. Dienes, J. Nemeth, Z. Z.
Nagy. Department of Ophthalmology, Semmelweis
University, Budapest, Hungary *CR
5278 — C0197 Corneal Collagen Crosslinking
in Keratoconic Eyes at Different Stages. Nurullah
Cagil, O. Sarac, E. Akcay, N. Ugurlu, E. Can,
G. Can. Department of Ophthalmology, Yildirim
Beyazit University, Ankara, Turkey
5279 — C0198 Shorter UVA Light Exposure
Protocol for Crosslinking in Keratoconus in
Children Without Progression Criteria. Andres
Codriansky1, 2, M. Aravena1, 2, M. Coria1, 2. 1Cornea
and Refractive Surgery, Hospital Sotero del Rio /
IOPA, Santiago, Chile; 2Cataract Surgery, Hospital
Sotero del Rio, Santiago, Chile
5280 — C0199 Papain Digestion Method for
Analysis of Cross-linking in Corneal Flaps. Sara
Rood-Ojalvo, P. Kamaev, M. D. Friedman, D.
Muller. Avedro Inc., Waltham, MA *CR
5281 — C0200 Accelerated UVA-RF Corneal
Cross-linking through Pulsed UVA Illumination
and Oxygen Rich Environments. David Muller,
P. Kamaev, M. D. Friedman, E. A. Sherr, W. A.
Eddington. Avedro, Waltham, MA *CR
5282 — C0201 Topical alternatives to
therapeutic riboflavin photochemical tissue
cross-linking: a comparison of cell toxicity
thresholds. Mi Jung Kim, Q. Wen, Q. V. Hoang, S.
L. Trokel, D. C. Paik. Ophthalmology, Columbia
University, College of Physicains and Surgeons,
New York, NY *CR, f
5283 — C0202 Corneal Thickness Changes
during Collagen Crosslinking using Riboflavin/
Dextran or Hypotonic Riboflavin. Elan A.
Rosenblat1, 2, A. L. Sachs2, S. A. Greenstein1, 2, P. S.
Hersh2, 1. 1Department of Ophthalmology, Inst of
Ophthalmology and Visual Science, Newark, NJ;
2
Cornea and Laser Eye Inst- Hersh Vision Group,
Teaneck, NJ *CR, f
5285 — C0204 Analysis of Thickness of
Corneas from Eye Banks After Application
Of Isosmolar Riboflavin And Hiposmolar
Riboflavin. Luiz Felipe L. Moraes2, 1, L. Barbosa2,
M. Macedo2, T. Rayes2. 1Ophthalmology, Federal
University of Pernambuco, Recife, Brazil;
2
Ophthalmology, Sorocaba Eye Bank, Sorocaba,
Brazil
5286 — C0205 Crosslinking Corneal Collagen
using Rose Bengal and Green Light. Irene E.
Kochevar1, T. Gisel1, E. E. Verter1, G. Scarcelli1, S.
H. Yun1, R. H. Webb1, R. W. Redmond1, S. Melki2.
1
Wellman Center for Photomedicine, Massachusetts
General Hospital, Boston, MA; 2Boston Eye Group,
Boston, MA *CR
5288 — C0207 Accelerated corneal crosslinking with pulsed light. Pavel Kamaev, W. A.
Eddington, S. Rood-Ojalvo, M. D. Friedman, D.
Muller. Research, Avedro, Waltham, MA *CR
5289 — C0208 Long term follow-up of
stiffening of rabbit corneas by WST11 using near
infrared light. Arie L. Marcovich1, 2, A. Brandis1, I.
Feine3, I. Pinkas1, R. Goldschmidt1, V. Kalchenko4,
D. H. Wagner5, Y. Salomon3, A. Scherz1. 1Plant
Sciences, Weizmann Institute of Science, Rehovot,
Israel; 2Ophthalmology, Kaplan Medical Center,
Rehovot, Israel; 3Biological Regulation, Weizmann
Institute of Science, Rehovot, Israel; 4Veterinary
Resources, Weizmann Institute of Science, Rehovot,
Israel; 5Materials and Interfaces, Weizmann Institue
of Science, Los Angeles, CA *CR
5290 — C0209 Antimicrobial efficacy of
riboflavin / UV-A collagen cross-linking at
different fluences in vitro. Florence Hoogewoud,
O. Richoz, F. Hafezi. Ophtalmology, University
Hospital of Geneva, Geneva, Switzerland *CR
5291 — C0210 Combination of Intracorneal
ring segments (Ferrara and Intacts) in the care
of patients with Keratoconus. Roberto Albertazzi1,
L. Ferlini1, L. D. Perrone1, D. M. Perrone1, G.
Rao1, J. F. Alfonso2, 3, J. Merayo-Lloves2, 3. 1Centro
de Ojos Quilmes, Quilmes, Argentina; 2Fundación
de Investigacion Oftalmologica - Instituto
Oftalmológico Fernández-Vega, oviedo, Spain;
3
University of Oviedo, oviedo, Spain *CR
5292 — C0211 Hydrogen-Loaded Eye Drops
Suppress Progression of Keratoconus-Like
Corneal Lesion of SKC Mouse. Naoko Kato1, 2,
Y. Uchino2, E. Inagaki2, S. Ohta3, K. Tsubota2.
1
Ophthalmology, National Defense Medical
College, Saitama, Japan; 2Ophthalmology, Keio
University School of Medicine, Tokyo, Japan;
3
Biochemistry and Cell Biology, Institute of
Development and Aging Sciences, Graduate School
of Medicine, Nippon Medical School, Kanagawa,
Japan *CR
5293 — C0212 Presence of lysyl oxidase-like
enzymes in human control and keratoconic
corneas. Lubica Dudakova, S. Kalasova, K.
Jirsova. Laboratory of the Biology and Pathology
of the Eye, Charles University, Prague, Czech
Republic
5294 — C0213 Anterior-segment OCT
epithelial mapping in early and advanced
keratoconic eyes. Feilin Zhu1, A. Kanellopoulos1, 2,
G. Asimellis2. 1Ophthalmology, NYU Medical
Center, New York, NY; 2Laservision Eye Institute,
Athens, Greece *CR
5295 — C0214 Low-frequency dielectric
spectroscopy of normal and keratoconus human
cornea. Dorota Tarnawska1, 3, A. Kocot1, M.
Jastrzebska2, E. Wylegala3, A. Ratuszna2. 1Dept.
of Biophysics and Molecular Physics, Institute of
Physics, University of Silesia, Katowice, Poland;
2
Department of Solid State Physics, Institute of
Physics, University of Silesia, Katowice, Poland;
3
Department of Ophthalmology, Railway Hospital,
Katowice, Poland
5296 — C0215 Correlation between
keratoconus progression and two cornea
topometric parameters: the regularity of the
pachymetric map (RPM) and the Index of height
decentration (IHD). George Asimellis, I. Kontari,
A. Kanellopoulos. Research, LaserVision.gr Eye
Institute, Athens, Greece *CR
5297 — C0216 Comparison of threedimensional optical coherence tomography
parameters for early keratoconus diagnosis.
Shinichi Fukuda1, S. Hoshi1, M. Yamanari2, 3, S.
Beheregaray1, T. Hiraoka1, Y. Yasuno2, T. Oshika1.
1
Ophthalmology, Tsukuba University, Tsukuba,
Japan; 2Computational Optics Group, Tsukuba
University, Tsukuba, Japan; 3Tomey Corporation,
Nagoya, Japan *CR
5298 — C0217 Decreased corneal sensitivity
to chemical and thermal stimuli in keratoconus
patients. Lorant Dienes1, K. Kranitz1, Z. Z. Nagy1,
J. Nemeth1, M. Acosta2, J. Gallar2, C. Belmonte2, I.
Kovacs1. 1Ophthalmology, Semmelweis University,
Budapest, Hungary; 2Instituto de Neurociencias,
Univ Miguel Hernandez-CSIC, Alicante, Spain *CR
5299 — C0218 Remodeling Processes in
Keratoconic Epithelium. Jesus Merayo-Lloves1,
A. Íñigo-Portugués1, E. Artime1, F. J. Colina1, F.
Bech1, J. F. Alfonso2, 1, L. M. Quirós3, A. Astudillo4,
M. Fernández2, 1, I. Alcalde1. 1Ocular Surface,
Fundación de Investigación Oftalmológica, Oviedo,
Spain; 2Ocular Surface, Instituto Oftalmológico
Fernández-Vega, Oviedo, Spain; 3Functional
Biology, Universidad de Oviedo, Oviedo, Spain;
4
Pathology, Hospital Central de Asturias, Oviedo,
Spain *CR
5300 — C0219 Phenotype of Keratoconus
Patients at King Khaled Eye Specialist Hospital.
Samar A. Al-Swailem, S. C. Yiu, A. Al-Assiri, N.
Asghar, A. Al-Qassimi. Anterior Segment, King
Khaled Eye Specialist Hosp, Riyadh, Saudi Arabia
5301 — C0220 Increased expression of
secreted frizzled-related protein-1 (SFRP-1) and
microtubule-associated protein light chain 3
(LC3) in keratoconus. Omer Iqbal, G. Fisher, S.
Vira, D. Kahn, D. Syed, J. Fareed, C. S. Bouchard.
Ophthalmology, Loyola, Maywood, IL
5302 — C0221 IL1B promoter polymorphisms
are associated with keratoconus in a Japanese
population. Takenori Mikami1, 2, A. Meguro1, T.
Teshigawara2, M. Takeuchi1, M. Ishioka1, 3, M.
Iwasaki3, K. Fukagawa3, K. Konomi4, J. Shimazaki4,
N. Mizuki1. 1Ophthalmology and Visual Science,
Yokohama City University Graduate School of
Medicine, Yokohama, Japan; 2Yokosuka Chuoh
Eye Clinic, Yokosuka, Japan; 3Ryogoku Eye Clinic,
Tokyo, Japan; 4Department of Ophthalmology,
Ichikawa General Hospital, Tokyo Dental College,
Ichikawa, Japan *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
335
Wednesday Posters
2:45 pm – 4:30 pm
5284 — C0203 Aliphatic β-nitroalcohols for
therapeutic corneoscleral tissue cross-linking:
catalytic studies. David C. Paik, Q. Wen, M.
Kim, Q. V. Hoang, S. L. Trokel. Ophthalmology,
Columbia University, New York, NY *CR
5287 — C0206 Collagen Crosslinking By
Infrared Femtosecond Pulses In Ex-vivo
Corneas. Juan M. Bueno, H. S. Ginis, R. Palacios,
A. Pennos, P. Artal. Laboratorio de Optica,
Universidad de Murcia, Murcia, Spain *CR
5303 – 5324 – Wednesday – Posters
5303 — C0222 Keratoconus Gene Mapping:
Candidate Genes in the 14q11.2 homozygous
region. Govindasamy Kumaramanickavel1, V.
Anandula1, V. Ramprasad3, N. Jeyabalan1, A.
Ghosh1, R. Shetty2. 1Basic Science Research,
Narayana Nethralaya, Bangalore, India; 2Cornea,
Narayana Nethralaya, Bangalore, India; 3SpincoBiotech, Chennai, India
5304 — C0223 Homozygosity Mapping of
Keratoconus to 12p13.1 region: The Ideal
Candidate Genes. Venkata Ramana Anandula1,
V. Anandula1, V. Ramprasad2, N. Jeyabalan1, R.
Shetty1, A. Ghosh1, G. Kumaramanickavel1. 1Basic
Science Research, Narayana Nethralaya, Bangalore,
India; 2Advanced Genomics, Spinco Biotech,
Chennai, India
5305 — C0224 Use of the polygenic model to
predict risk of keratoconus using GWAS data.
Xiaohui Li1, 2, Y. Bykhovskaya2, 3, T. Haritunians1,
D. Siscovick4, A. J. Aldave5, L. B. SzczotkaFlynn6, S. K. Iyengar7, J. I. Rotter1, K. Taylor1, Y.
S. Rabinowitz3. 1Medical Genetics, Cedars-Sinai
Medical Center, Los Angeles, CA; 2Cornea Genetic
Eye Institute, Cedars-Sinai Medical Center, Los
Angeles, CA; 3Regenerative Medicine Institute,
Cedars-Sinai Medical Center, Los Angeles, CA;
4
Cardiovascular Health Research Unit, University
of Washington, Seattle, WA; 5The Jules Stein Eye
Institute, University of California Los Angeles, Los
Angeles, CA; 6Ophthalmology & Visual Sciences,
Case Western Reserve University, Cleveland,
OH; 7Epidemiology & Biostatistics, Case Western
Reserve University, Cleveland, OH *CR
Exhibit Hall D0067-D0100
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Clinical/Epidemiologic Research
478 Vision Function and Quality of Life
Wednesday Posters
2:45 pm – 4:30 pm
Moderators: Pradeep Y. Ramulu and
Beatriz E. Munoz
5306 — D0067 What are people rating when
they rate their vision status? Associations with
Vision Tests and Self-Reported Visual Function
in the Salisbury Eye Evaluation Study. Mahmood
El-Gasim1, B. E. Munoz2, S. K. West2, A. W. Scott3.
1
School of Medicine, Johns Hopkins University,
Baltimore, MD; 2Dana Center for Preventive
Ophthalmology, Johns Hopkins University,
Baltimore, MD; 3Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD
5307 — D0068 Controlling Photophobia and
Light-Induced Headache: the Use of Artificial
Pupil Contact Lenses. Mary M. Jackowski1, 2,
B. Motter1, 3. 1VA Medical Center, Syracuse,
NY; 2Ophthalmology, SUNY Upstate Medical
University, Syracuse, NY; 3Neuroscience and
Physiology, SUNY Upstate Medical University,
Syracuse, NY
5308 — D0069 Quantifying the Impact of
Vision Training using Short Duration Transient
Visual Evoked Potential (SD-tVEP). Robert
Orsillo1, P. H. Derr2. 1Orsillo Vision Care,
Tallahasse, FL; 2Diopsys Inc, Pine Brook, NJ *CR
5309 — D0070 Quality of life of Keratoconus
Patients in an Asian Population. Hon Kiat
Wong, J. Lim, W. Heng. Ophthalmology, National
Healthcare Group Eye Institute, Tan Tock Seng
Hospital, Singapore, Singapore
5310 — D0071 Dry eye and Changes in Driving
Habits: The Salisbury Eye Evaluation. Jamie
Brown1, E. K. Akpek1, S. W. van Landingham1, S.
K. West1, 2, B. E. Munoz1, 2, P. Y. Ramulu1, 2. 1Johns
Hopkins Wilmer Eye Institute, Baltimore, MD;
2
Dana Center for Preventive Ophthalmology,
Baltimore, MD *CR
5311 — D0072 Comparing Better-eye and
Integrated Visual Field Mean Deviation as
Metrics for Capturing Visual Disability. Karun
S. Arora, M. V. Boland, D. S. Friedman, J. L.
Jefferys, S. K. West, P. Y. Ramulu. Ophthalmology,
Johns Hopkins University School of Medicine,
BALTIMORE, MD *CR
5312 — D0073 Comparing the Impact of
Refractive and Non-Refractive Vision Loss on
Disability. Nazlee Zebardast, S. K. West, B. E.
Munoz, P. Y. Ramulu. Johns Hopkins Wilmer Eye
Institute, Baltimore, MD
5313 — D0074 Rasch analysis of the glaucomaspecific module of the Eye-tem Bank project.
Konrad Pesudovs1, J. Khadka1, E. K. Fenwick2,
E. L. Lamoureux2, 3. 1NHMRC Ctr Clin Eye Res/
Optometry, Flinders University SA, Adelaide, SA,
Australia; 2Centre for Eye Research Australia,
University of Melbourne, Melbourne, VIC,
Australia; 3Singapore Eye Research Institute,
Singapore National Eye Centre, Singapore,
Singapore
5314 — D0075 Cognitive dysfunction reduces
vision-specific quality of life in older Asian
adults. Peggy P. Chiang1, 3, C. Sabanayagam1,
3
, Y. Zheng5, T. Y. Wong1, 4, E. L. Lamoureux2,
1 1
. Epidemiol, Hlth Services Rsrch, Singapore
Eye Research Inst, Singapore, Singapore;
2
Ophthalmology, Centre for Eye Research Australia,
University of Melbourne, Melbourne, VIC,
Australia; 3Duke-NUS Graduate Medical School,
Singapore, Singapore; 4Ophthalmology, Department
of Ophthalmology, National University of
Singapore, Singapore, Singapore; 5Ophthalmology,
Zhongshan Ophthalmic Center, Sun Yat-Sen
University, Guangzhou, China *CR
5315 — D0076 Assessment of Disability
Weights Associated with Visual Acuity
Impairment in Patients from a University
Hospital in Brazil. Solange R. Salomao1, N. N.
Cavascan1, A. Berezovsky1, M. R. Mitsuhiro1,
P. Y. Sacai1, A. Araujo-Filho1, P. A. Morales1,
S. E. Watanabe1, R. Belfort1, L. B. Ellwein2.
1
Departamento de Oftalmologia, Universidade
Federal de Sao Paulo, Sao Paulo, Brazil; 2NEI,
Bethesda, MD *CR
5316 — D0077 New Method for the
Classification of Vitreous Floaters and Study
of their Correlations with Ocular Biometry.
Irene Ruiz1, 2, J. J. Rozema1, 2, M. B. Tassignon1, 2.
1
Ophthalmology, Antwerp University Hospital,
Edegem, Belgium; 2Medicine and Health Science,
University of Antwerp, Wilrijk, Belgium
5317 — D0078 Participants’ experiences in a
clinical trial for vision restoration: Motivation
to participate, visual perception and functional
use, and experience of loss following termination.
Frank J. Lane1, P. R. Troyk2, K. P. Nitsch1.
1
Pyschology, Illinois Insitute of Technology,
Chicago, IL; 2Biomedical Engineering, Illinois
Insitute of Technology, Chicago, IL *CR
5318 — D0079 Developing a questionnaire to
measure the quality of life of Blepharitis patients.
Linda Bourque1, 2, M. M. Kelley1, 2, K. Hosseini2.
1
Fielding School of Public Hlth, University of
California, Los Angeles, Los Angeles, CA; 2InSite
Vision, Inc., Alameda, CA *CR, f
5319 — D0080 Evaluation of Methods
Handling Missing Diary Data for Statistical
Analysis in Dry Eye Studies. Hui-Chun T. Hsu, D.
W. Usner, R. Abelson. Biostatistics, Statistics and
Data Corporation, Tempe, AZ *CR
5320 — D0081 Visual Function Affects
Reported Depressive Symptoms and Suicidal
Ideation in Older Adults. Priyanka Jain1, M.
Smith2, J. V. Odom1, G. Miller1, C. Moore1, M.
J. Leys1. 1WVU Eye Institute, Morgantown,
WV; 2Psychology, West Virginia University,
Morgantown, WV
5321 — D0082 Subjective Influences on Visual
Acuity Testing Performance: A Prospective
Study with Non-accommodating Intra-ocular
Lenses. Arvind V. Iyer1, E. R. Chu2, B. X. Pan2, B.
S. Tjan3, A. A. Sadun2, K. L. Lu2, F. E. Udwadia4.
1
Biomedical Engineering, University of Southern
California, Los Angeles, CA; 2Ophthalmology,
University of Southern California, Los Angeles,
CA; 3Psychology, University of Southern California,
Los Angeles, CA; 4Aerospace and Mechanical
Engineering, University of Southern California, Los
Angeles, CA *CR
5322 — D0083 Educational and vision-assistive
smartphone Apps for patients: a quantitative
evaluation. Stephanie Kletke1, S. Arora2, F. Adatia3.
1
Medicine, McMaster University, Hamilton,
ON, Canada; 2Ophthalmology, University of
Alberta, Edmonton, AB, Canada; 3Ophthalmology,
University of Calgary, Calgary, AB, Canada
5323 — D0084 Patient Experience During the
Fitting Process for the Prosthetic Replacement of
the Ocular Surface Ecosystem (PROSE) Device.
Eda Dou, Y. Wang, R. M. St Clair, M. N. Lee, M.
Rosenblatt, P. Sood, A. G. Alzaga Fernandez, C.
E. Starr, J. Ciralsky, K. C. Sippel. Ophthalmology,
Weill Cornell Medical College, New York, NY
5324 — D0085 Importance of Physical Activity
and Low Vision: Preliminary Findings from
an Adaptive Sport and Recreation Program
for Military Service Members with Low
Vision. Laura E. Dreer1, 2, C. Block1, A. Wood1, S.
Robinson2, M. Goff2, L. Malone2. 1Ophthalmology/
Callahan Eye Fndtn Hosp, Univ of Alabama
at Birmingham, Birmingham, AL; 2Lakeshore
Foundation, Birmingham, AL *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
336
Wednesday – Posters – 5325 – 5347
5325 — D0086 Fear of falling, activity
restriction and self-reported physical function
among older adults with glaucoma. Alex A.
Black, J. M. Wood. School of Optometry and Vision
Science, Queensland University of Technology,
Brisbane, QLD, Australia
5326 — D0087 Can chronic visual symptoms
measures accurately predict acute visual
discomfort symptoms? Stefanie A. Drew1, A.
Escobar2, C. Liu3, E. Castellanos3, L. R. Stark4,
E. Borsting4, C. Chase3. 1Psychology, California
State University, Northridge, Northridge, CA;
2
2U, Inc., Landover, MD; 3College of Optometry,
Western University of Health Sciences, Pomona,
CA; 4Southern California College of Optometry,
Fullerton, CA f
5327 — D0088 Contrast Sensitivity,
Electroretinography and Optical Coherence
Tomography Changes in Young Subjects After
an Acute Unacclimatized Short Exposure to
High Altitude. Mehmet S. Karakucuk, B. Polat,
E. Mirza, H. Arda, K. Gumus, A. Oner. Dept. of
Ophthalmology, Erciyes University Faculty of
Medicine, Kayseri, Turkey
5328 — D0089 Age-related eye disease and
cognitive status. Solmaz Moghadaszadeh1, H.
Boisjoly1, 2, M. Kergoat3, J. Rousseau3, F. Djafari1, 2,
E. E. Freeman1, 2. 1Ophtalmology, MaisonneuveRosemont’s Hospital, Montreal, QC, Canada;
2
Ophthalmology, Université de Montréal, Montreal,
QC, Canada; 3Centre de Recherche, Institut
universitaire de gériatrie de Montréal, Montreal,
QC, Canada
5329 — D0090 DIGS and ADAGES:
Relationship Between Rates of Binocular
Visual Field Loss and Vision-Related Quality of
Life in Glaucoma. Renato Lisboa1, 2, Y. Chun1, 3,
L. M. Zangwill1, R. N. Weinreb1, P. Rosen1, J.
M. Liebmann4, C. A. Girkin5, F. A. Medeiros1.
1
Ophthalmology, Hamilton Glaucoma Center, La
Jolla, CA; 2Ophthalmology, Federal University of
São Paulo, São Paulo, Brazil; 3Ophthalmology,
Chung-Ang University, Seoul, Republic of Korea;
4
Opthtalmology, New York Eye and Ear Infirmary,
Ney York, NY; 5Ophthalmology, University of
Alabama, Birmingham, AL *CR, f
5334 — D0095 Is visual impairment just
another comorbid condition? Bonnielin K.
Swenor, B. E. Munoz, S. K. West. Ophthalmology,
Johns Hopkins Wilmer Eye Institute, Baltimore,
MD
5335 — D0096 Development of an Arabic
version of the National Eye Institute Visual
Function Questionnaire as a tool to study eye
diseases patients in Egypt. Nizar F. Saleh1, 2, A. A.
Salama3, M. A. Abdel-Baqy4, M. E. Israel5, G. A.
Elhawary5, A. E. Radwan3, T. M. EL Nakhal2, I. T.
Elkhateb6, A. M. Kassem2, M. Amgad6. 1Cortoba Eye
Femtolaser Centers, Cairo, Egypt; 2Ophthalmology,
Faculty of Medicine University of Alexandria,
Alexandria, Egypt; 3Ophthalmology, Faculty of
Medicine - Menofeyya University, Shebin El-Kom,
Egypt; 4Alexandria Regional Center for Women’s
Health & Development, Alexandria, Egypt; 5Faculty
of Medicine - Ain Shams University, Cairo, Egypt;
6
Faculty of Medicine - Cairo University, Cairo,
Egypt
5336 — D0097 The Impact of Visual Field Loss
and Hearing Loss on Social Function. Bei Bei
Chen, N. Zebardast, F. R. Lin, P. Y. Ramulu, D. S.
Friedman. Johns Hopkins, Baltimore, MD *CR
5337 — D0098 The Effect of Comprehensive
Vision Rehabilitation on Self-Administration
of Medication in Patients with Central Vision
Loss. Catherine J. Choi, J. Wallis, M. Jackson.
Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA f
5338 — D0099 Blue streetlights effect on visual
acuity in glaucoma. Kozo Masuda1, H. Uozato2.
1
Health and Social Services, Osaka University of
Human Sciences, Settsu, Japan; 2Ophthalmology
and Visual Science, Kitasato University,
Sagamihara, Japan
5339 — D0100 How Maryland Eye Care
Practitioners Complete the Motor Vehicle
Administration (MVA)Vision Screening
Form. Ruidi Wang, R. Miller, H. D. Jampel.
Ophthalmology, Johns Hopkins Wilmer Eye
Institute, Baltimore, MD *CR
Exhibit Hall D0101-D0113
Wednesday, May 08, 2013 2:45 PM-4:30 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
479 Oculoplastics and Orbital Disease:
Prognosis, Diagnosis and Outcomes
Moderator: Timothy J. McCulley
5340 — D0101 Periorbital and Ocular Injury
from Industrial Hooks. Daniel G. Straka, S.
Thinda, M. R. Melson, L. A. Mawn. Ophthalmology,
Vanderbilt Eye Institute, Nashville, TN *CR
5341 — D0102 Predictors and Outcomes of
Orbital Floor Fractures requiring Surgical
repair. Clarissa Cheng, L. Lee. Ophthalmology,
National Healthcare Group Eye Institute, Tan Tock
Seng Hospital, Singapore, Singapore
5342 — D0103 Observation of the orbital floor
with magnetic resonance imaging after surgery
for orbital floor fractures. Hidetoshi Onda, T.
Ueda, Y. Kamijo, M. Yoshida. Ophthalmology,
Showa Univ Sch of Medicine, Tokyo, Japan
5343 — D0104 Orbital and Preseptal Cellulitis:
Our Experience at a Referral Center in
Southeast Louisiana. Namita Bhardwaj1, 2, A. B.
al-Hariri1. 1Department of Ophthalmology, Ochsner
Clinic Foundation, New Orleans, LA; 2Department
of Ophthalmology, Louisiana State University, New
Orleans, LA
5344 — D0105 Orbital Cerebrospinal Fluid
Leak Following Pterional Orbitozygomatic
Craniotomy. Zakeya M. Alsadah1, M. K. Yoon3, T.
J. McCulley2, 1. 1oculoplastics, kkesh, riyadh, Saudi
Arabia; 2oculoplastics, Wilmer Eye Institute, Johns
Hopkins, baltimore, MD; 3Massachusetts Eye and
Ear Infirmary, boston, MA
5345 — D0106 Cosmetic and quality of life
outcomes of the direct brow lift. Srinivas Sai A.
Kondapalli1, C. N. Czyz2, J. A. Foster3, K. V. Cahill3.
1
Ophthalmology, Loyola University Medical Center,
Westchester, IL; 2Ophthalmology, Ohio University,
Doctor’s Hospital, Columbus, OH; 3Ophthalmology,
The Ohio State University, Columbus, OH
5346 — D0107 The effect of eyelid
manipulation on exophthalmometry values.
Aubrey Gilbert, M. K. Yoon. Ophthalmology,
Massachusetts Eye and Ear Infirmary, Boston, MA
5347 — D0108 Age Related Gender Differences
in the Occurrence of Acquired Nasolacrimal
Duct Obstruction in Saudi Arabia. Laura Phan1,
T. J. McCulley1, 2. 1Ophthalmology, Wilmer Eye
Institute, Baltimore, MD; 2Ophthalmology, King
Khaled Eye Specialist Hospital, Riyadh, Saudi
Arabia
5331 — D0092 An iPad Test of Letter Contrast
Sensitivity. Mark A. Bullimore1, M. E. Jansen2, E. J.
Kollbaum2, P. S. Kollbaum2. 1College of Optometry,
University of Houston, Boulder, CO; 2School of
Optometry, Indiana University, Bloomington, IN
*CR
5332 — D0093 Fear of falling in age-related
macular degeneration. Sabyasachi Sengupta, S.
W. van Landingham, R. W. Massof, E. Chan, D.
S. Friedman, P. Y. Ramulu. Wilmer Eye Institute,
Baltimore, MD *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
337
Wednesday Posters
2:45 pm – 4:30 pm
5330 — D0091 Utility and Uncorrected
Refractive Error. Nina Tahhan1, 2, E. B. Papas1, 3,
T. R. Fricke1, K. D. Frick4, B. A. Holden1, 3. 1Brien
Holden Vision Institute, Sydney, NSW, Australia;
2
School of Optometry & Vision Science, UNSW,
Sydney, NSW, Australia; 3Vision Cooperative
Research Centre, Sydney, NSW, Australia; 4Johns
Hopkins Bloomberg School of Public Health,
Baltimore, MD *CR
5333 — D0094 Photophobia and LightInduced Headache: Novel Long-Term
Effects of Pilocarpine. Brad Motter1, 3, M. M.
Jackowski1, 2. 1VA Medical Center, Syracuse,
NY; 2Ophthalmology, SUNY Upstate Medical
University, Syracuse, NY; 3Neuroscience and
Physiology, SUNY Upstate Medical University,
Syracuse, NY
5348 – 5352 – Wednesday – Posters
5348 — D0109 Giant fornix syndrome with
chronic methicillin resistant staphylococcus
aureus conjunctivitis causing nasal lacrimal
duct obstruction. Jackson F. Lever1, E. Eubanks2,
C. K. Gupta1, A. Barmettler1, J. Servat3, F.
Nesi-Eloff1. 1Beaumont Eye Institute, William
Beaumont Hospital, Royal Oak, MI; 2School of
Medicine, Wayne State University, Detroit, MI;
3
Ophthalmology, Yale School of Medicine, New
Haven, CT
5349 — D0110 Pott’s Puffy Tumor Arising
From Pansinusitis - A Mimicker of Preseptal
Cellulitis. Li Wei Heng, E. Poh. Ophthalmology,
Tan Tock Seng Hospital, Singapore, Singapore
5350 — D0111 Ki67 Proliferation Index
as a Prognostic Factor in Ocular Adnexal
Lymphoma. Matthew C. Sniegowski, B. Esmaeli.
University of Texas MD Anderson Cancer Cencer,
Houston, TX
5351 — D0112 Histopathology after temporary
tarsorrhaphy. Larissa K. Ghadiali1, K. C. Piotti2,
G. J. Lelli3. 1Ophthalmology, New York Medical
College, Valhalla, NY; 2Department of Pathology
and Laboratory Medicine, New York Presbyterian
Hospital-Weill Cornell Medical Center, New York,
NY; 3Ophthalmology, New York Presbyterian
Hospital-Weill Cornell Medical Center, New York,
NY
Wednesday Posters
2:45 pm – 4:30 pm
5352 — D0113 Recognition of External Eye
Photos: HIPAA Implications. Maya H. Maloney,
E. Bradley. Ophthalmology, Mayo Clinic,
Rochester, MN
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
338
Wednesday – Lectures – 5353 – 5354
6E
Wednesday, May 08, 2013 6:30 PM-7:15 PM
481A Cogan Award and Lecture
The Cogan Award recognizes a young researcher
who is 40 years of age or less at the time of
nomination. This person will have made important
and worthwhile contributions to research in
ophthalmology or visual science which directly
relates to disorders of the human eye or visual
system, and will have shown substantial promise for
the future.
— 5:30 Introduction. Peter Sterling. Library,
University of Pennsylvania, Philadelphia, PA
5353 — 5:35 Neural Circuits and Synapses
for Early Visual Processing. Jonathan B. Demb.
Ophthalmology & Visual Science, Yale University,
New Haven, CT
6E
Wednesday, May 08, 2013 6:30 PM-7:15 PM
481B Friedenwald Award and Lecture
The Friedenwald Award is presented annually
to recognize outstanding research in the basic or
clinical sciences as applied to ophthalmology.
— 6:30 Introduction. Joseph A. Izatt. Biomed
Engineering/Ophthal, Duke University, Durham,
NC *CR
5354 — 6:35 Functional & Structural Optical
Coherence Tomography. David Huang. Casey Eye
Institute, Oregon Health & Science Univ, Portland,
OR *CR
Wednesday Lectures
6:30 pm – 7:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
339
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